Pub Date : 2020-01-01DOI: 10.1515/nanofab-2020-0100
Saman Sargazi, Seyedeh Maryam Hosseinikhah, Farshid Zargari, N. Chauhana, Mohadeseh Hassanisaadi, S. Amani
Abstract Cisplatin (Cis) is an effective cytotoxic agent, but its administration has been challenged by kidney problems, reduced immunity system, chronic neurotoxicity, and hemorrhage. To address these issues, pH-responsive non-ionic surfactant vesicles (niosomes) by Span 60 and Tween 60 derivatized by cholesteryl hemisuccinate (CHEMS), a pH-responsive agent, and Ergosterol (helper lipid), were developed for the first time to deliver Cis. The drug was encapsulated in the niosomes with a high encapsulation efficiency of 89%. This system provided a responsive release of Cis in pH 5.4 and 7.4, thereby improving its targeted anticancer drug delivery. The noisome bilayer model was studied by molecular dynamic simulation containing Tween 60, Span 60, Ergosterol, and Cis molecules to understand the interactions between the loaded drug and noisome constituents. We found that the platinum and chlorine atoms in Cis are critical factors in distributing the drug between water and bilayer surface. Finally, the lethal effect of niosomal Cis was investigated on the MCF7 breast cancer cell line using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results from morphology monitoring and cytotoxic assessments suggested a better cell-killing effect for niosomal Cis than standard Cis. Together, the synthesis of stimuli-responsive niosomes could represent a promising delivery strategy for anticancer drugs.
{"title":"pH-responsive cisplatin-loaded niosomes: synthesis, characterization, cytotoxicity study and interaction analyses by simulation methodology","authors":"Saman Sargazi, Seyedeh Maryam Hosseinikhah, Farshid Zargari, N. Chauhana, Mohadeseh Hassanisaadi, S. Amani","doi":"10.1515/nanofab-2020-0100","DOIUrl":"https://doi.org/10.1515/nanofab-2020-0100","url":null,"abstract":"Abstract Cisplatin (Cis) is an effective cytotoxic agent, but its administration has been challenged by kidney problems, reduced immunity system, chronic neurotoxicity, and hemorrhage. To address these issues, pH-responsive non-ionic surfactant vesicles (niosomes) by Span 60 and Tween 60 derivatized by cholesteryl hemisuccinate (CHEMS), a pH-responsive agent, and Ergosterol (helper lipid), were developed for the first time to deliver Cis. The drug was encapsulated in the niosomes with a high encapsulation efficiency of 89%. This system provided a responsive release of Cis in pH 5.4 and 7.4, thereby improving its targeted anticancer drug delivery. The noisome bilayer model was studied by molecular dynamic simulation containing Tween 60, Span 60, Ergosterol, and Cis molecules to understand the interactions between the loaded drug and noisome constituents. We found that the platinum and chlorine atoms in Cis are critical factors in distributing the drug between water and bilayer surface. Finally, the lethal effect of niosomal Cis was investigated on the MCF7 breast cancer cell line using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results from morphology monitoring and cytotoxic assessments suggested a better cell-killing effect for niosomal Cis than standard Cis. Together, the synthesis of stimuli-responsive niosomes could represent a promising delivery strategy for anticancer drugs.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"6 1","pages":"1 - 15"},"PeriodicalIF":2.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67057085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.1515/nanofab-2019-0001
Yi Zhou, Honghui Wu, Y. Ping, Jianqing Gao
Abstract Functional biomaterials that are capable of effectively carrying therapeutic agents and specifically delivering therapeutics to pathological sites have been widely investigated over decades. Recently, cellular carriers and cell derivative-based bio-hybrid delivery systems have drawn extensive attention as a promising branch of therapeutic delivery systems, owing to their low immunogenicity and intriguing biomimetic capabilities. Various approaches for the fabrication of these biomimetic carriers have been developed, and some products have already been commercialized as well. In this review, we summarized various processing methods for engineering cell-derived biomimetic drug delivery systems, and discussed their future outlooks.
{"title":"Fabrication of Cell-Derived Biomimetic Drug Delivery System","authors":"Yi Zhou, Honghui Wu, Y. Ping, Jianqing Gao","doi":"10.1515/nanofab-2019-0001","DOIUrl":"https://doi.org/10.1515/nanofab-2019-0001","url":null,"abstract":"Abstract Functional biomaterials that are capable of effectively carrying therapeutic agents and specifically delivering therapeutics to pathological sites have been widely investigated over decades. Recently, cellular carriers and cell derivative-based bio-hybrid delivery systems have drawn extensive attention as a promising branch of therapeutic delivery systems, owing to their low immunogenicity and intriguing biomimetic capabilities. Various approaches for the fabrication of these biomimetic carriers have been developed, and some products have already been commercialized as well. In this review, we summarized various processing methods for engineering cell-derived biomimetic drug delivery systems, and discussed their future outlooks.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"5 1","pages":"1 - 18"},"PeriodicalIF":2.9,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/nanofab-2019-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47732712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract DNA as life’s genetic material has been widely investigated around the world. In recent years, with the fiery researches on nanomaterials, it also plays an important role in the development of material science due to its extraordinary molecular recognition capability and prominent structural features. In this mini review, we mainly overview the recent progresses of DNA guiding self-assembled nanostructures and nanofabrication. Typical DNA tile-based assembly and DNA origami nanotechnologies are presented, utilizing the recent 3D topology methods to fabricate multidimensional structures with unique properties. Then the site-specific nanomaterials synthesis and nano-DNA recognition on different DNA scaffolds/templates are demonstrated with excellent addressability, biocompatibility and structural programmability. Various nanomaterials, such as metals, carbon family materials, quantum dots, metal-organic frameworks, and DNA-based liquid crystals are briefly summarized. Finally, the present limitation and future promising development directions are discussed in conclusion and perspective. We wish this review would provide useful information toward the broader scientific interests in DNA nanotechnology.
{"title":"Recent Advances in Novel DNA Guiding Nanofabrication and Nanotechnology","authors":"Zhiguang Suo, Jingqi Chen, Ziheng Hu, Yihao Liu, Feifei Xing, Lingyan Feng","doi":"10.1515/nanofab-2018-0003","DOIUrl":"https://doi.org/10.1515/nanofab-2018-0003","url":null,"abstract":"Abstract DNA as life’s genetic material has been widely investigated around the world. In recent years, with the fiery researches on nanomaterials, it also plays an important role in the development of material science due to its extraordinary molecular recognition capability and prominent structural features. In this mini review, we mainly overview the recent progresses of DNA guiding self-assembled nanostructures and nanofabrication. Typical DNA tile-based assembly and DNA origami nanotechnologies are presented, utilizing the recent 3D topology methods to fabricate multidimensional structures with unique properties. Then the site-specific nanomaterials synthesis and nano-DNA recognition on different DNA scaffolds/templates are demonstrated with excellent addressability, biocompatibility and structural programmability. Various nanomaterials, such as metals, carbon family materials, quantum dots, metal-organic frameworks, and DNA-based liquid crystals are briefly summarized. Finally, the present limitation and future promising development directions are discussed in conclusion and perspective. We wish this review would provide useful information toward the broader scientific interests in DNA nanotechnology.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"4 1","pages":"32 - 52"},"PeriodicalIF":2.9,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/nanofab-2018-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47454938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-17DOI: 10.1515/nanofab-2018-0001
Xiwei Wang, Wei Lai, Tiantian Man, Xiangmeng Qu, Li Li, A. Chandrasekaran, H. Pei
Abstract Biosensor design is important to bioanalysis yet challenged by the restricted target accessibility at the biomolecule-surface (bio-surface). The last two decades have witnessed the appearance of various “art-like” DNA nanostructures in one, two, or three dimensions, and DNA nanostructures have attracted tremendous attention for applications in diagnosis and therapy due to their unique properties (e.g., mechanical flexibility, programmable control over their shape and size, easy and high-yield preparation, precise spatial addressability and biocompatibility). DNA nanotechnology is capable of providing an effective approach to control the surface functionality, thereby increasing the molecular recognition ability at the biosurface. Herein, we present a critical review of recent progress in the development of DNA nanostructures in one, two and three dimensions and highlight their biological applications including diagnostics and therapeutics. We hope that this review provides a guideline for bio-surface engineering with DNA nanostructures.
{"title":"Bio-surface engineering with DNA scaffolds for theranostic applications","authors":"Xiwei Wang, Wei Lai, Tiantian Man, Xiangmeng Qu, Li Li, A. Chandrasekaran, H. Pei","doi":"10.1515/nanofab-2018-0001","DOIUrl":"https://doi.org/10.1515/nanofab-2018-0001","url":null,"abstract":"Abstract Biosensor design is important to bioanalysis yet challenged by the restricted target accessibility at the biomolecule-surface (bio-surface). The last two decades have witnessed the appearance of various “art-like” DNA nanostructures in one, two, or three dimensions, and DNA nanostructures have attracted tremendous attention for applications in diagnosis and therapy due to their unique properties (e.g., mechanical flexibility, programmable control over their shape and size, easy and high-yield preparation, precise spatial addressability and biocompatibility). DNA nanotechnology is capable of providing an effective approach to control the surface functionality, thereby increasing the molecular recognition ability at the biosurface. Herein, we present a critical review of recent progress in the development of DNA nanostructures in one, two and three dimensions and highlight their biological applications including diagnostics and therapeutics. We hope that this review provides a guideline for bio-surface engineering with DNA nanostructures.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"4 1","pages":"1 - 16"},"PeriodicalIF":2.9,"publicationDate":"2018-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/nanofab-2018-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49588050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-05-01DOI: 10.1515/nanofab-2018-0002
Ran Chen, Junfeng Liu, Zeyong Sun, D. Chen
Abstract Electrospinning can produce nanofibers with extremely high surface-to-volume ratio and well tunable properties. The technique has been widely used in different disciplines. To fabricate fibers with required properties, parameters of fabrication should be well controlled and adjusted according to specific applications. Modification of electrospinning devices to align fibers in highly ordered architectures could improve their functions. Enhanced efficiency have also been obtained through the upscaling modification of spinnerets. With the outstanding efficiency, electrospinning has exhibited huge potentials to construct various nanostructures, such as artificial vessel, membrane for desalination and so on.
{"title":"Functional Nanofibers with Multiscale Structure by Electrospinning","authors":"Ran Chen, Junfeng Liu, Zeyong Sun, D. Chen","doi":"10.1515/nanofab-2018-0002","DOIUrl":"https://doi.org/10.1515/nanofab-2018-0002","url":null,"abstract":"Abstract Electrospinning can produce nanofibers with extremely high surface-to-volume ratio and well tunable properties. The technique has been widely used in different disciplines. To fabricate fibers with required properties, parameters of fabrication should be well controlled and adjusted according to specific applications. Modification of electrospinning devices to align fibers in highly ordered architectures could improve their functions. Enhanced efficiency have also been obtained through the upscaling modification of spinnerets. With the outstanding efficiency, electrospinning has exhibited huge potentials to construct various nanostructures, such as artificial vessel, membrane for desalination and so on.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"4 1","pages":"17 - 31"},"PeriodicalIF":2.9,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/nanofab-2018-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49662561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-20DOI: 10.2478/nanofab-2017-0002
Zheng Cao, Yuyuan Chen, Qianpeng Zhang, Yanping Xia, Gang Liu, Dun Wu, Wenzhong Ma, Junfeng Cheng, Chunlin Liu
Abstract The polyanion polystyrene sulfonate (PSS), the polycation poly (allylamine hydrochloride) (PAH), and the anionic poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AA)] microgels were self-assembled onto the polyethylene imine (PEI) adsorbed gold surfaces of quartz crystal microbalance (QCM) because of the electrostatic attractions. The interactions of various metal particles including Ca2+, Bi3+, Cu2+, Zn2+, Ni2+, Sn2+, Co2+, and Cd2+ with the obtained PEI/PSS/PAH/microgel layer in aqueous solutions were evaluated by QCM. The PEI/PSS/PAH/Microgel covered QCM sensor demonstrates the lowest detection limit of 0.1 ppm in aqueous solutions and the obviously linear connection between the frequency response and Ni2+ concentration from 0.1 to 20 ppm, which is due to the complexation of Ni2+ with the carboxyl groups of microgels. Atomic force microscopy (AFM) was used to reveal the morphology and stability of the self-assembled polyelectrolyte/microgel layer before and after adsorbing heavy metal ions. These self-assembled materials of polyelectrolyte/microgel layer will be helpful for manufacturing ion-selective materials for separation and identification purposes.
{"title":"Preparation and ion sensing property of the self-assembled microgels by QCM","authors":"Zheng Cao, Yuyuan Chen, Qianpeng Zhang, Yanping Xia, Gang Liu, Dun Wu, Wenzhong Ma, Junfeng Cheng, Chunlin Liu","doi":"10.2478/nanofab-2017-0002","DOIUrl":"https://doi.org/10.2478/nanofab-2017-0002","url":null,"abstract":"Abstract The polyanion polystyrene sulfonate (PSS), the polycation poly (allylamine hydrochloride) (PAH), and the anionic poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AA)] microgels were self-assembled onto the polyethylene imine (PEI) adsorbed gold surfaces of quartz crystal microbalance (QCM) because of the electrostatic attractions. The interactions of various metal particles including Ca2+, Bi3+, Cu2+, Zn2+, Ni2+, Sn2+, Co2+, and Cd2+ with the obtained PEI/PSS/PAH/microgel layer in aqueous solutions were evaluated by QCM. The PEI/PSS/PAH/Microgel covered QCM sensor demonstrates the lowest detection limit of 0.1 ppm in aqueous solutions and the obviously linear connection between the frequency response and Ni2+ concentration from 0.1 to 20 ppm, which is due to the complexation of Ni2+ with the carboxyl groups of microgels. Atomic force microscopy (AFM) was used to reveal the morphology and stability of the self-assembled polyelectrolyte/microgel layer before and after adsorbing heavy metal ions. These self-assembled materials of polyelectrolyte/microgel layer will be helpful for manufacturing ion-selective materials for separation and identification purposes.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"3 1","pages":"16 - 25"},"PeriodicalIF":2.9,"publicationDate":"2017-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/nanofab-2017-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43219167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-28DOI: 10.2478/nanofab-2017-0028
Kunfeng Chen, D. Xue
Abstract The development of advanced electrode materials for high-performance energy storage devices becomes more and more important for growing demand of portable electronics and electrical vehicles. To speed up this process, rapid screening of exceptional materials among various morphologies, structures and sizes of materials is urgently needed. Benefitting from the advance of nanotechnology, tremendous efforts have been devoted to the development of various nanofabrication strategies for advanced electrode materials. This review focuses on the analysis of novel nanofabrication strategies and progress in the field of fast screening advanced electrode materials. The basic design principles for chemical reaction, crystallization, electrochemical reaction to control the composition and nanostructure of final electrodes are reviewed. Novel fast nanofabrication strategies, such as burning, electrochemical exfoliation, and their basic principles are also summarized. More importantly, colloid system served as one up-front design can skip over the materials synthesis, accelerating the screening rate of highperformance electrode. This work encourages us to create innovative design ideas for rapid screening high-active electrode materials for applications in energy-related fields and beyond.
{"title":"Nanofabrication strategies for advanced electrode materials","authors":"Kunfeng Chen, D. Xue","doi":"10.2478/nanofab-2017-0028","DOIUrl":"https://doi.org/10.2478/nanofab-2017-0028","url":null,"abstract":"Abstract The development of advanced electrode materials for high-performance energy storage devices becomes more and more important for growing demand of portable electronics and electrical vehicles. To speed up this process, rapid screening of exceptional materials among various morphologies, structures and sizes of materials is urgently needed. Benefitting from the advance of nanotechnology, tremendous efforts have been devoted to the development of various nanofabrication strategies for advanced electrode materials. This review focuses on the analysis of novel nanofabrication strategies and progress in the field of fast screening advanced electrode materials. The basic design principles for chemical reaction, crystallization, electrochemical reaction to control the composition and nanostructure of final electrodes are reviewed. Novel fast nanofabrication strategies, such as burning, electrochemical exfoliation, and their basic principles are also summarized. More importantly, colloid system served as one up-front design can skip over the materials synthesis, accelerating the screening rate of highperformance electrode. This work encourages us to create innovative design ideas for rapid screening high-active electrode materials for applications in energy-related fields and beyond.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"3 1","pages":"1 - 15"},"PeriodicalIF":2.9,"publicationDate":"2017-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/nanofab-2017-0028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42945361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-25DOI: 10.1515/nanofab-2015-0006
G. Seniutinas, G. Gervinskas, J. Anguita, D. Hakobyan, E. Brasselet, S. Juodkazis
Abstract Focused ion beam (FIB) milling with a 10 nm resolution is used to directly write metallic metasurfaces and micro-optical elements capable to create structured light fields. Surface density of fabricated nano-features, their edge steepness as well as ion implantation extension around the cut line depend on the ion beam intensity profile. The FIB beam intensity cross section was evaluated using atomic force microscopy (AFM) scans of milled line arrays on a thin Pt film. Approximation of two Gaussian intensity distributions describes the actual beam profile composed of central high intensity part and peripheral wings. FIB fabrication reaching aspect ratio of 10 in gold film is demonstrated.
{"title":"Nano-proximity direct ion beam writing","authors":"G. Seniutinas, G. Gervinskas, J. Anguita, D. Hakobyan, E. Brasselet, S. Juodkazis","doi":"10.1515/nanofab-2015-0006","DOIUrl":"https://doi.org/10.1515/nanofab-2015-0006","url":null,"abstract":"Abstract Focused ion beam (FIB) milling with a 10 nm resolution is used to directly write metallic metasurfaces and micro-optical elements capable to create structured light fields. Surface density of fabricated nano-features, their edge steepness as well as ion implantation extension around the cut line depend on the ion beam intensity profile. The FIB beam intensity cross section was evaluated using atomic force microscopy (AFM) scans of milled line arrays on a thin Pt film. Approximation of two Gaussian intensity distributions describes the actual beam profile composed of central high intensity part and peripheral wings. FIB fabrication reaching aspect ratio of 10 in gold film is demonstrated.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"2 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/nanofab-2015-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67056990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-05DOI: 10.1515/nanofab-2015-0005
A. Urtizberea, Michael Hirtz, H. Fuchs
Abstract Dip-pen nanolithography (DPN) and Polymer pen lithography (PPL) are powerful lithography techniques being able to pattern a wide range of inks. Transport and surface spreading depend on the ink physicochemical properties, defining its diffusive and fluid character. Structure assembly on surface arises from a balance between the entanglement of the ink itself and the interaction with the substrate. According to the transport characteristics, different models have been proposed. In this article we review the common types of inks employed for patterning, the particular physicochemical characteristics that make them flow following different dynamics as well as the corresponding transport mechanisms and models that describe them.
{"title":"Ink transport modelling in Dip-Pen Nanolithography and Polymer Pen Lithography","authors":"A. Urtizberea, Michael Hirtz, H. Fuchs","doi":"10.1515/nanofab-2015-0005","DOIUrl":"https://doi.org/10.1515/nanofab-2015-0005","url":null,"abstract":"Abstract Dip-pen nanolithography (DPN) and Polymer pen lithography (PPL) are powerful lithography techniques being able to pattern a wide range of inks. Transport and surface spreading depend on the ink physicochemical properties, defining its diffusive and fluid character. Structure assembly on surface arises from a balance between the entanglement of the ink itself and the interaction with the substrate. According to the transport characteristics, different models have been proposed. In this article we review the common types of inks employed for patterning, the particular physicochemical characteristics that make them flow following different dynamics as well as the corresponding transport mechanisms and models that describe them.","PeriodicalId":51992,"journal":{"name":"Nanofabrication","volume":"2 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2016-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/nanofab-2015-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67056925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：