Colloid Journal最新文献

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Study of Cryostructuring of Polymer System. 65. Features of Changes in the Physicochemical Properties of Poly(vinyl alcohol) Cryogels Caused by the Action of Aqueous Solutions of Amino Acids of General Formula H2N–(CH2)n–COOH 聚合物体系的冷冻结构研究。65.通式为 H2N-(CH2)n-COOH 的氨基酸水溶液作用下聚乙烯醇冷凝凝胶理化性质变化的特征

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2024-01-26 DOI: 10.1134/s1061933x23600781

O. Yu. Kolosova, A. S. Ryzhova, V. P. Chernyshev, V. I. Lozinsky

Abstract

Macroporous cryogels of poly(vinyl alcohol) (PVA) have been prepared by the cryogenic processing (freezing at –20°C for 12 h followed by defrosting through heating at a rate of 0.03°C/min) of aqueous PVA solutions with a polymer concentration of 100 g/L. The character of changes in the physicochemical parameters of the cryogels has been studied after equilibrating their samples with aqueous solutions of amino acids of general formula H₂N–(CH₂)_n–COOH (n = 1–5). It has been shown that these amino acids, glycine (n = 1) and ε-aminocaproic acid (n = 5) to the highest and lowest extent, respectively, impose a kosmotropic action on the properties of the PVA cryogels causing a decrease in their volume, a significant increase in the compression elasticity modulus, and a rise in the fusion temperature of the samples. Nevertheless, H₂N–(CH₂)_n–COOH amino acids are released from the cryogels saturated with amino acid solutions into an external aqueous environment with no significant diffusion hindrances. After cryogels loaded with amino acids are exhaustively rinsed with pure water, their physicochemical parameters do not return completely to the values observed for the samples before their treatment with solutions of such amino acids due to the formation of additional H-bonded nodes of a three-dimensional network, with their formation being promoted by kosmotropic amino acids in the bulk of the already formed cryogels.

摘要聚乙烯醇（PVA）的多孔冷凝凝胶是通过对聚合物浓度为 100 克/升的 PVA 水溶液进行低温处理（在 -20°C 下冷冻 12 小时，然后以 0.03°C/min 的速度加热解冻）制备的。用通式为 H2N-(CH2)n-COOH（n = 1-5）的氨基酸水溶液平衡冷凝胶样品后，研究了冷凝胶理化参数的变化特征。结果表明，这些氨基酸（甘氨酸（n = 1）和ε-氨基己酸（n = 5）的浓度分别最高和最低）对 PVA 低温凝胶的特性产生了各向同性作用，导致其体积减小，压缩弹性模量显著增加，样品的熔融温度升高。然而，H2N-(CH2)n-COOH 氨基酸从饱和氨基酸溶液的冷凝胶中释放到外部水环境中，没有明显的扩散障碍。在用纯水彻底冲洗负载了氨基酸的冷凝胶后，它们的物理化学参数并没有完全恢复到样品在用这种氨基酸溶液处理之前的值，这是因为形成了三维网络的额外 H 键节点，它们的形成是由已经形成的冷凝胶主体中的各向同性氨基酸促进的。

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引用次数: 0

Mechanochemical Synthesis of Ethoxyaminohumic Acids and Surface-Active Properties of Their Solutions at Solution–Air Interface 乙氧基氨基铝酸的机械化学合成及其溶液在溶液-空气界面上的表面活性特性

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2024-01-26 DOI: 10.1134/s1061933x23600963

S. L. Khil’ko, V. S. Shelest, M. I. Rogatko, R. A. Makarova, R. G. Semenova

Abstract—

Ethoxyamine derivatives of humic acids have been obtained by mechanochemical synthesis via the simultaneous interaction of humic acids with poly(ethylene glycol) (PEG-6000 and PEG-1500) and an aminating reagent (urea, hydroperitum, or cyanoguanidine) in a vibrating apparatus. Reaction products have been characterized by IR spectroscopy, acid–base potentiometric titration, and viscometry. Tensiometric and rheological characteristics of the surface layers of solutions of salts of the synthesized derivatives of humic acids have been studied by the pendant drop and oscillating pendant drop methods. The solutions of the salts of ethoxyaminohumic acids have been found to exhibit a pronounced surface activity at the air–water interface. The experimental dependences of the viscoelastic modulus on the surface pressure and the concentration of the solutions of ethoxyaminohumic acid salts are in satisfactory agreement with the functions calculated in terms of the theoretical model of bimolecular adsorption. The presence of amino groups in the structure of ethoxyaminohumic acids predetermines their high solubility in the acidic pH region. The simultaneous incorporation of ethoxy and amino groups into humic acid macromolecules makes it possible to obtain a novel type of surfactants, which combine three functions, i.e., the functions of anionic, cationic, and nonionic surfactants.

摘要--腐植酸乙氧基胺衍生物是通过机械化学合成法获得的，其方法是在振动装置中将腐植酸与聚（乙二醇）（PEG-6000 和 PEG-1500）和胺化试剂（尿素、氢过硫酸盐或氰基胍）同时作用。通过红外光谱、酸碱电位滴定和粘度计对反应产物进行了表征。通过悬滴法和振荡悬滴法研究了腐植酸合成衍生物盐溶液表层的张力和流变特性。研究发现，乙氧基氨基腐植酸盐溶液在空气-水界面上表现出明显的表面活性。粘弹性模量对乙氧基氨基铝酸盐溶液表面压力和浓度的实验依赖关系与根据双分子吸附理论模型计算出的函数完全一致。乙氧基氨基铝酸结构中氨基的存在决定了其在酸性 pH 值区域的高溶解度。在腐植酸大分子中同时加入乙氧基和氨基，可以获得一种新型表面活性剂，它兼具阴离子、阳离子和非离子表面活性剂的三种功能。

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引用次数: 0

Stabilization of Swellable Aluminosilicate Suspensions 稳定可膨胀硅酸铝悬浮液

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2024-01-26 DOI: 10.1134/s1061933x2360094x

K. A. Ovchinnikov, E. V. Podlesnova, F. E. Safarov, A. T. Akhmetov, A. V. Fakhreeva, E. I. Gusarova, N. A. Sergeeva, A.G. Telin

Abstract

The goal of this study is to increase the energy efficiency of pipeline hydraulic transport of water-swellable aluminosilicate dispersions. A model commercial suspension, the filler of which is a complex mixture of aluminosilicates, has been used to develop an approach that makes it possible to improve the technological properties of such suspensions. Modification of the suspensions consists in adding organic and inorganic inhibitors of swelling of dispersed phase particles, as well as nonionic surfactants. The influence of the additives leads to a decrease in the yield stress and an increase in sedimentation stability of the heterogeneous systems. It has been shown that the use of the complex modifying additive prevents the particles of the model suspension from agglomeration and provides it with sedimentation stability at temperatures up to 70°C, which is important for the technical process in which the suspension is intended to be used. Technically, the research is of an applied nature. A well-known approach to modifying suspensions is used, which consists in combating the aggregation of dispersed phase particles and blocking ion exchange between them and the dispersion medium. The performed set of rheological shear and oscillation tests and the study of the sedimentation stability of the suspensions in the presence of various modifying additives have resulted in optimizing their composition. The practical result of the work is the successful hydrotransport of the suspension in which the content of the dispersed phase is 50% higher than that in the unmodified suspension, thus increasing the energy efficiency of the process.

摘要本研究的目标是提高水膨胀硅酸铝分散体管道水力运输的能效。我们使用了一种商业悬浮液模型（其填料是一种复杂的铝硅酸盐混合物）来开发一种方法，从而有可能改善这种悬浮液的技术特性。悬浮液的改良包括添加有机和无机分散相颗粒膨胀抑制剂以及非离子表面活性剂。在添加剂的影响下，异质体系的屈服应力降低，沉降稳定性提高。研究表明，使用复合改性添加剂可以防止模型悬浮液的颗粒团聚，并使其在高达 70°C 的温度下具有沉降稳定性，这对于悬浮液的使用技术过程非常重要。从技术上讲，这项研究具有应用性质。我们采用了一种众所周知的方法来改良悬浮液，即防止分散相颗粒聚集并阻止它们与分散介质之间的离子交换。通过流变剪切和振荡试验，以及对悬浮液在各种改性添加剂作用下的沉降稳定性的研究，对悬浮液的成分进行了优化。这项工作的实际成果是成功实现了悬浮液的水力传输，其中分散相的含量比未改性悬浮液高出 50%，从而提高了工艺的能效。

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引用次数: 0

Dynamic Properties of Pulmonary Lipid Monolayers on the Surfaces of Sodium Polystyrene Sulfonate and Polydiallyldimethylammonium Chloride Solutions 聚苯乙烯磺酸钠和聚二烯丙基二甲基氯化铵溶液表面肺脂质单层的动态特性

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2023-12-12 DOI: 10.1134/s1061933x23600677

A. G. Bykov, M. A. Panaeva

Abstract

Pulmonary surfactant, which is a complex mixture of lipids and proteins, plays a key role in the functional properties of the respiratory system. Lipids form complexes with proteins to maintain low values of surface tension at continuous compression/expansion deformations. However, interactions that lead to the complexation still remain to be unknown thus significantly hampering the development of synthetic analogs of the natural pulmonary surfactant. In this work, the methods of surface rheology and ellipsometry have been employed to study the dynamic properties of model phospholipid monolayers applied onto the surfaces of synthetic polyelectrolyte solutions. It has been shown, that electrostatic or hydrophobic interactions between lipids and macromolecules are insufficient for the efficient complexation and maintenance of low surface tension values.

摘要肺表面活性物质是一种复杂的脂质和蛋白质混合物，在呼吸系统的功能特性中起着关键作用。脂质与蛋白质形成复合物，在连续压缩/膨胀变形时保持较低的表面张力。然而，导致络合的相互作用仍然是未知的，因此严重阻碍了天然肺表面活性剂的合成类似物的发展。本文采用表面流变学和椭偏学的方法研究了应用于合成聚电解质溶液表面的磷脂单层模型的动力学性质。研究表明，脂质和大分子之间的静电或疏水相互作用不足以有效络合和维持低表面张力值。

引用次数: 0

Nanoemulsions and Solid Lipid Nanoparticles with Encapsulated Doxorubicin and Thymoquinone 包裹多柔比星和胸腺醌的纳米乳液和固体脂质纳米颗粒

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2023-12-12 DOI: 10.1134/s1061933x23600707

E. V. Mishchenko, A. M. Gileva, E. A. Markvicheva, M. Yu. Koroleva

Abstract—

Nanoemulsions (NEs) and solid lipid nanoparticles (SLNs) are promising drug delivery systems. In this work, paraffin oil NEs and stearic acid SLNs stabilized with Tween 60 and Span 60 have been studied. NEs with an average droplet diameter of ~50 nm and suspensions of SLNs with an average size of ~30 nm are stable to aggregation for more than 90 days. The rates of penetration of lipid particles into cancer cells (C6 and MCF-7) depend on their sizes. After incubation for 1 h, lipid nanoparticles ~50 nm in size penetrate into cells, are distributed in their internal space, and concentrate in the nuclei. The cytotoxicity of doxorubicin- or thymoquinone-loaded NEs and SLNs against MCF-7 and HTC 116 cell lines is higher than the cytotoxicity of the individual substances. Wherein, unloaded NEs and SLNs show low cytotoxicity. The obtained results demonstrate that paraffin oil NEs and stearic acid SLNs are promising to be used as carriers of both lipophilic and amphiphilic drugs, including doxorubicin and thymoquinone. The accumulation of lipid nanoparticles with sizes smaller than 100 nm in cell nuclei is an advantage of such systems for the delivery of anticancer drugs, because this leads to DNA replication suppression followed by cell apoptosis.

纳米乳剂(NEs)和固体脂质纳米颗粒(SLNs)是很有前途的给药系统。本文研究了用Tween 60和Span 60稳定石蜡油ne和硬脂酸sln。平均液滴直径为~50 nm的纳米粒子和平均尺寸为~30 nm的纳米粒子悬浮液在90天以上的时间内都能稳定聚集。脂质颗粒进入癌细胞(C6和MCF-7)的渗透速率取决于它们的大小。孵育1 h后，约50 nm大小的脂质纳米颗粒进入细胞内部，分布于细胞内部空间，并集中于细胞核内。负载多柔比星或百里醌的NEs和sln对MCF-7和HTC 116细胞系的细胞毒性高于单个物质的细胞毒性。其中，未载的ne和sln表现出低细胞毒性。研究结果表明，石蜡油网和硬脂酸网均可作为多柔比星和百里醌等亲脂性和两亲性药物的载体。细胞核中小于100纳米的脂质纳米颗粒的积累是这种系统用于递送抗癌药物的一个优势，因为这导致DNA复制抑制，随后是细胞凋亡。

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引用次数: 0

Stimuli-Responsive Drug Delivery Systems Based on Bilayer Lipid Vesicles: New Trends 基于双层脂质囊泡的刺激响应型给药系统：新趋势

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2023-12-12 DOI: 10.1134/s1061933x23600690

A. A. Efimova, A. V. Sybachin

Abstract

The development of new efficient methods for combating serious diseases, among which, oncological and infectious diseases hold a special place, remains to be an urgent challenge of biomedicine and biotechnology. Currently, the efforts of scientists are focused on the search for drug systems that provide high efficiency of treatment with minimal impacts on a human body. The development of this field has led to the creation of stimuli-responsive liposomes that can release an encapsulated drug under a specific stimulus, such as temperature, pH, electromagnetic field, light, etc. Being stimulated, lipid bilayer vesicles change their structure, size, surface charge, or phase state, thus leading to a controlled release of the drug in a specific place of the body, thereby resulting in a more accurate and efficient delivery. This review discusses the current trends in the development of liposome-based stimuli-responsive systems for the controlled delivery of biologically active substances.

摘要开发新的有效方法来对抗重大疾病，其中肿瘤和感染性疾病占有特殊地位，仍然是生物医学和生物技术面临的紧迫挑战。目前，科学家们的工作重点是寻找对人体影响最小的高效治疗药物系统。这一领域的发展导致了刺激反应脂质体的产生，这种脂质体可以在特定的刺激下释放被封装的药物，如温度、pH值、电磁场、光等。脂质双分子层囊泡在受到刺激后，会改变其结构、大小、表面电荷或相态，从而导致药物在体内特定部位的可控释放，从而实现更准确、更有效的给药。本文综述了目前以脂质体为基础的刺激反应系统的发展趋势，以控制生物活性物质的递送。

引用次数: 0

Enzyme-Like Activity of Cerium Dioxide Colloidal Solutions Stabilized with L-Malic Acid 用 L-苹果酸稳定的二氧化铈胶体溶液的酶样活性

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2023-12-12 DOI: 10.1134/s1061933x23600653

A. D. Filippova, A. E. Baranchikov, V. K. Ivanov

Abstract

For the first time, stable aqueous colloidal solutions of cerium dioxide stabilized with L-malic acid have been obtained at ligand : CeO₂ molar ratios of 0.2, 0.5, 1.0, and 2.0. Using dynamic light scattering, it has been shown that CeO₂ sols are characterized by a narrow monomodal size distribution of aggregates, and the sols remain to be aggregatively stable in a Tris-HCl buffer solution. According to the chemiluminescence analysis of the enzyme-like activity of cerium dioxide sols with respect to hydrogen peroxide, the surface modification of the cerium dioxide particles with malic acid increases the enzyme-like activity of СеО₂ up to 4.5 times.

摘要本文首次在CeO2摩尔比为0.2、0.5、1.0和2.0的条件下，获得了l -苹果酸稳定二氧化铈的稳定胶体水溶液。动态光散射表明，CeO2溶胶具有聚集体尺寸窄的单峰分布特征，并且在Tris-HCl缓冲溶液中保持聚集体稳定。根据对二氧化铈溶胶相对于过氧化氢的类酶活性的化学发光分析，苹果酸对二氧化铈颗粒的表面改性使СеО2的类酶活性提高了4.5倍。

引用次数: 0

Lipid Nanoparticles for Lutein Encapsulation and Delivery 用于叶黄素封装和输送的脂质纳米颗粒

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2023-12-12 DOI: 10.1134/s1061933x2360063x

A. D. Shirokikh, Y. A. Guruleva, E. A. Marinets, M. Y. Koroleva

Abstract

Recently, lipid nanoparticles have been intensively studied as carriers of lipophilic drugs. In this work, we have studied the stability of nanoemulsions with paraffin oil, solid lipid nanoparticles with stearic acid, and nanostructured lipid particles with paraffin oil and stearic acid in a mass ratio of 1 : 1. The obtained results have shown that all studied lipid systems stabilized with nonionic surfactants Tween 60 and Span 60 were stable to aggregation and subsequent sedimentation for more than 30 days. The incorporation of lutein into the lipid particles has almost no effect on their stability, while the size of solid lipid nanoparticles and nanostructured lipid nanoparticles decreases from 28–30 to 15–17 nm. The bioavailability of lutein loaded in lipid nanoparticles is evaluated from their effect on the restoration of blood flow velocity by simulating hemic hypoxia. Almost immediately after the application of lipid nanoparticles, the blood flow velocity ceases to decrease, and a tendency to its restoration is observed in 5–10 min. This shows that lipid nanoparticles with paraffin oil and stearic acid are promising candidates for the delivery of lipophilic drugs.

摘要近年来，脂质纳米颗粒作为亲脂性药物的载体得到了广泛的研究。在这项工作中，我们研究了纳米乳液与石蜡油、固体脂质纳米颗粒与硬脂酸、纳米结构脂质颗粒与石蜡油和硬脂酸的质量比为1:1的稳定性。结果表明，用非离子表面活性剂Tween 60和Span 60稳定的脂质体系在30天以上对聚集和随后的沉降都是稳定的。叶黄素掺入脂质颗粒对其稳定性几乎没有影响，而固体脂质纳米颗粒和纳米结构脂质纳米颗粒的尺寸从28-30 nm减小到15-17 nm。脂质纳米颗粒中装载叶黄素的生物利用度通过模拟缺氧对血流速度恢复的影响来评估。应用脂质纳米颗粒后，血流速度几乎立即停止下降，并在5-10分钟内观察到血流速度恢复的趋势。这表明含有石蜡油和硬脂酸的脂质纳米颗粒是传递亲脂性药物的有希望的候选者。

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引用次数: 0

Nanoparticle Concentration as an Important Parameter for Characterization of Dispersion and Its Applications in Biomedicine 纳米粒子浓度作为表征分散性的重要参数及其在生物医学中的应用

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2023-12-12 DOI: 10.1134/s1061933x23600720

T. N. Pashirova, Z. M. Shaihutdinova, E. B. Souto, P. Masson, V. F. Mironov

Abstract

Currently, there are problems to standardize methods for determining the concentration of nanoparticles and creation of etalon materials for calibrating measured concentrations. Accurate determination of nanoparticle concentration is necessary to assess the maximum dose of administered nanotherapeutics for diagnostics and therapy in vivo, to determine the order of reaction in enzymatic nanoreactors. In addition, this parameter determines biological effects, such as the formation of a protein corona on the outer surface of nanoparticles that precedes nanoparticles’ absorption and internalization in cells. This review discusses the most common methods for determining the concentration of nanoparticles based on direct visualization, using microscopy, light absorption or light scattering, direct counting of nanoparticles, and gravimetry. Results may differ from one method to the other. Thus, the use of a combination of several methods provides more reliable results. The advantages, disadvantages and ways to improve accuracy of results are also presented.

摘要目前，在确定纳米粒子浓度的方法和创建用于校准测量浓度的标准子材料方面存在一些问题。准确测定纳米颗粒浓度对于评估体内诊断和治疗中使用的纳米治疗药物的最大剂量以及确定酶促纳米反应器中的反应顺序是必要的。此外，该参数还决定了生物效应，例如在纳米颗粒被细胞吸收和内化之前，在纳米颗粒的外表面形成蛋白质冠。本文讨论了基于直接可视化、显微镜、光吸收或光散射、纳米颗粒直接计数和重量法的最常用的测定纳米颗粒浓度的方法。不同方法的结果可能不同。因此，结合使用几种方法可以提供更可靠的结果。文中还介绍了该方法的优点、缺点和提高结果准确性的方法。

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引用次数: 0

Biocompatible Hydrogels Based on Biodegradable Polyesters and Their Copolymers 基于生物可降解聚酯及其共聚物的生物相容性水凝胶

IF 1.1 4区化学 Q3 Chemistry

Colloid Journal

Pub Date : 2023-12-12 DOI: 10.1134/s1061933x23600756

Yu. S. Fomina, A. S. Semkina, Yu. D. Zagoskin, M. M. Aleksanyan, S. N. Chvalun, T. E. Grigoriev

Abstract

Poly(ethylene glycol)-based hydrogels have long proved to be promising materials for various biomedical technologies. This review considers systems based on the most common and studied copolymers of poly(ethylene glycol) and biodegradable polyesters of lactide and glycolide. Traditional and modern approaches to the synthesis of the copolymers and the production of hydrogels have been considered, the studies of the structure and properties of the materials have been analyzed, and the main directions of the application of these products in practice have been described.

摘要聚乙二醇基水凝胶是一种很有前途的生物医学材料。本综述考虑了基于最常见和研究的聚乙二醇共聚物和可生物降解的丙交酯和乙二醇酯聚酯的体系。讨论了传统和现代的共聚物合成方法和水凝胶的制备方法，分析了材料的结构和性能研究，并描述了这些产品在实际应用中的主要方向。

引用次数: 0

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