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Advances in 3D printing scaffolds for peripheral nerve and spinal cord injury repair 3D打印支架修复周围神经和脊髓损伤的研究进展
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-29 DOI: 10.1088/2631-7990/acde21
Juqing Song, Baiheng Lv, Wen-Chien Chen, Peng Ding, Yong He
Because of the complex nerve anatomy and limited regeneration ability of natural tissue, the current treatment effect for long-distance peripheral nerve regeneration and spinal cord injury (SCI) repair is not satisfactory. As an alternative method, tissue engineering is a promising method to regenerate peripheral nerve and spinal cord, and can provide structures and functions similar to natural tissues through scaffold materials and seed cells. Recently, the rapid development of 3D printing technology enables researchers to create novel 3D constructs with sophisticated structures and diverse functions to achieve high bionics of structures and functions. In this review, we first outlined the anatomy of peripheral nerve and spinal cord, as well as the current treatment strategies for the peripheral nerve injury and SCI in clinical. After that, the design considerations of peripheral nerve and spinal cord tissue engineering were discussed, and various 3D printing technologies applicable to neural tissue engineering were elaborated, including inkjet, extrusion-based, stereolithography, projection-based, and emerging printing technologies. Finally, we focused on the application of 3D printing technology in peripheral nerve regeneration and spinal cord repair, as well as the challenges and prospects in this research field.
由于神经解剖结构复杂,自然组织再生能力有限,目前远端周围神经再生和脊髓损伤修复的治疗效果并不理想。作为一种替代方法,组织工程是再生周围神经和脊髓的一种很有前途的方法,它可以通过支架材料和种子细胞提供与自然组织相似的结构和功能。近年来,3D打印技术的快速发展使研究人员能够创造出结构复杂、功能多样的新型3D结构,实现结构和功能的高度仿生学。在这篇综述中,我们首先概述了周围神经和脊髓的解剖结构,以及目前临床对周围神经损伤和脊髓损伤的治疗策略。然后,讨论了周围神经和脊髓组织工程的设计考虑,并阐述了适用于神经组织工程的各种3D打印技术,包括喷墨打印、挤压打印、立体光刻、投影打印和新兴打印技术。最后,我们重点介绍了3D打印技术在周围神经再生和脊髓修复中的应用,以及该研究领域面临的挑战和前景。
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引用次数: 0
Recent advances in nanofiber-based flexible transparent electrodes 纳米纤维基柔性透明电极的研究进展
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-22 DOI: 10.1088/2631-7990/acdc66
Houchao Zhang, Xiaoyan Zhu, Yuping Tai, Junyi Zhou, Hongke Li, Zhenghao Li, Rui Wang, Jinbao Zhang, Youchao Zhang, Wensong Ge, Fan Zhang, Luanfa Sun, Guangming Zhang, Hongbo Lan
Flexible and stretchable transparent electrodes are widely used in smart display, energy, wearable devices and other fields. Due to the limitations of flexibility and stretchability of indium tin oxide electrodes, alternative electrodes have appeared, such as metal films, metal nanowires, and conductive meshes. However, few of the above electrodes can simultaneously have excellent flexibility, stretchability, and optoelectronic properties. Nanofiber (NF), a continuous ultra-long one-dimensional conductive material, is considered to be one of the ideal materials for high-performance transparent electrodes with excellent properties due to its unique structure. This paper summarizes the important research progress of NF flexible transparent electrodes (FTEs) in recent years from the aspects of NF electrode materials, preparation technology and application. First, the unique advantages and limitations of various NF materials are systematically discussed. Then, we summarize the preparation technology of various advanced NF FTEs, and point out the future development trend. We also discuss the application of NFs in solar cells, supercapacitors, electric heating equipments, sensors, etc, and analyze its development potential in flexible electronic equipment, as well as problems that need to be solved. Finally, the challenges and future development trends are proposed in the wide application of NF FTEs in the field of flexible optoelectronics.
柔性、可拉伸透明电极广泛应用于智能显示、能源、可穿戴设备等领域。由于氧化铟锡电极的柔韧性和可拉伸性的限制,出现了金属薄膜、金属纳米线和导电网等替代电极。然而,很少有上述电极可以同时具有优异的柔韧性、可拉伸性和光电子性能。纳米纤维(NF)是一种连续超长一维导电材料,由于其独特的结构特点,被认为是制造高性能透明电极的理想材料之一。本文从纳滤电极材料、制备工艺和应用等方面综述了近年来纳滤柔性透明电极的重要研究进展。首先,系统地讨论了各种NF材料的独特优势和局限性。然后总结了各种先进的NF fte的制备技术,并指出了未来的发展趋势。讨论了纳米碳纳米管在太阳能电池、超级电容器、电热设备、传感器等方面的应用,分析了纳米碳纳米管在柔性电子设备中的发展潜力以及需要解决的问题。最后,提出了NF fte在柔性光电子领域广泛应用所面临的挑战和未来的发展趋势。
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引用次数: 9
Acousto-optic scanning spatial-switching multiphoton lithography 声光扫描空间开关多光子光刻技术
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-21 DOI: 10.1088/2631-7990/ace0a7
Binzhang Jiao, Fayu Chen, Yuncheng Liu, Xuhao Fan, Shaoqun Zeng, Qi Dong, Leimin Deng, Hui Gao, Wei Xiong
Nano-3D printing has obtained widespread attention owing to its capacity to manufacture end-use components with nano-scale features in recent years. Multiphoton lithography (MPL) is one of the most promising 3D nanomanufacturing technologies, which has been widely used in manufacturing micro-optics, photonic crystals, microfluidics, meta-surface, and mechanical metamaterials. Despite of tremendous potential of MPL in laboratorial and industrial applications, simultaneous achievement of high throughput, high accuracy, high design freedom, and a broad range of material structuring capabilities remains a long-pending challenge. To address the issue, we propose an acousto-optic scanning with spatial-switching multispots (AOSS) method. Inertia-free acousto-optic scanning and nonlinear swept techniques have been developed for achieving ultrahigh-speed and aberration-free scanning. Moreover, a spatial optical switch concept has been implemented to significantly boost the lithography throughput while maintaining high resolution and high design freedom. An eight-foci AOSS system has demonstrated a record-high 3D printing rate of 7.6 × 107 voxel s−1, which is nearly one order of magnitude higher than earlier scanning MPL, exhibiting its promise for future scalable 3D nanomanufacturing.
近年来,纳米3d打印因其具有制造具有纳米级特征的最终用途部件的能力而受到广泛关注。多光子光刻技术(MPL)是最具发展前景的三维纳米制造技术之一,已广泛应用于制造微光学、光子晶体、微流体、元表面和机械超材料等领域。尽管MPL在实验室和工业应用中具有巨大的潜力,但同时实现高通量、高精度、高设计自由度和广泛的材料结构能力仍然是一个长期悬而未决的挑战。为了解决这个问题,我们提出了一种空间切换多点声光扫描方法。为实现超高速、无像差扫描,发展了无惯性声光扫描和非线性扫描技术。此外,还实现了空间光开关概念,以显着提高光刻吞吐量,同时保持高分辨率和高设计自由度。8焦AOSS系统的3D打印速率达到了创纪录的7.6 × 107体素s−1,比之前的扫描MPL高了近一个数量级,显示出其在未来可扩展的3D纳米制造领域的前景。
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引用次数: 1
Nanomaterial-based flexible sensors for metaverse and virtual reality applications 基于纳米材料的柔性传感器,用于虚拟现实和虚拟现实应用
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-15 DOI: 10.1088/2631-7990/acded1
Jianfei Wang, Jiao Suo, Zhengxun Song, Wen Jung Li, Zuobin Wang
Nanomaterial-based flexible sensors (NMFSs) can be tightly attached to the human skin or integrated with clothing to monitor human physiological information, provide medical data, or explore metaverse spaces. Nanomaterials have been widely incorporated into flexible sensors due to their facile processing, material compatibility, and unique properties. This review highlights the recent advancements in NMFSs involving various nanomaterial frameworks such as nanoparticles, nanowires, and nanofilms. Different triggering interaction interfaces between NMFSs and metaverse/virtual reality (VR) applications, e.g. skin-mechanics-triggered, temperature-triggered, magnetically triggered, and neural-triggered interfaces, are discussed. In the context of interfacing physical and virtual worlds, machine learning (ML) has emerged as a promising tool for processing sensor data for controlling avatars in metaverse/VR worlds, and many ML algorithms have been proposed for virtual interaction technologies. This paper discusses the advantages, disadvantages, and prospects of NMFSs in metaverse/VR applications.
基于纳米材料的柔性传感器(NMFSs)可以紧密附着在人体皮肤上或与衣服集成,以监测人体生理信息,提供医疗数据或探索超空间。纳米材料由于其易于加工、材料相容性和独特的性能而被广泛应用于柔性传感器中。本文综述了纳米纤维结构的最新进展,包括纳米颗粒、纳米线和纳米膜等各种纳米材料框架。讨论了nmfs与虚拟现实(VR)应用程序之间的不同触发交互接口,例如皮肤力学触发、温度触发、磁触发和神经触发接口。在连接物理世界和虚拟世界的背景下,机器学习(ML)已经成为处理传感器数据以控制虚拟世界/虚拟现实世界中的化身的有前途的工具,并且已经提出了许多ML算法用于虚拟交互技术。本文讨论了nmfs在虚拟现实/虚拟现实应用中的优点、缺点和前景。
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引用次数: 1
Additive manufacturing of promising heterostructure for biomedical applications 具有生物医学应用前景的异质结构增材制造
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-15 DOI: 10.1088/2631-7990/acded2
C. Shuai, Desheng Li, Xiong Yao, xia Li, Chengde Gao
As a new generation of materials/structures, heterostructure is characterized by heterogeneous zones with dramatically different mechanical, physical or chemical properties. This endows heterostructure with unique interfaces, robust architectures, and synergistic effects, making it a promising option as advanced biomaterials for the highly variable anatomy and complex functionalities of individual patients. However, the main challenges of developing heterostructure lie in the control of crystal/phase evolution and the distribution/fraction of components and structures. In recent years, additive manufacturing techniques have attracted increasing attention in developing heterostructure due to the unique flexibility in tailored structures and synthetic multimaterials. This review focuses on the additive manufacturing of heterostructure for biomedical applications. The structural features and functional mechanisms of heterostructure are summarized. The typical material systems of heterostructure, mainly including metals, polymers, ceramics, and their composites, are presented. And the resulting synergistic effects on multiple properties are also systematically discussed in terms of mechanical, biocompatible, biodegradable, antibacterial, biosensitive and magnetostrictive properties. Next, this work outlines the research progress of additive manufacturing employed in developing heterostructure from the aspects of advantages, processes, properties, and applications. This review also highlights the prospective utilization of heterostructure in biomedical fields, with particular attention to bioscaffolds, vasculatures, biosensors and biodetections. Finally, future research directions and breakthroughs of heterostructure are prospected with focus on their more prospective applications in infection prevention and drug delivery.
异质结构作为新一代的材料/结构,其特点是具有显著不同的机械、物理或化学性质的异质区。这使得异质结构具有独特的界面,坚固的结构和协同效应,使其成为高度可变解剖结构和个体患者复杂功能的先进生物材料的有希望的选择。然而,发展异质结构的主要挑战在于控制晶体/相演化以及组分和结构的分布/比例。近年来,增材制造技术因其在定制结构和合成多材料方面的独特灵活性,在异质结构的发展中受到越来越多的关注。本文综述了异质结构增材制造在生物医学领域的应用。综述了异质结构的结构特点和作用机理。介绍了典型的异质结构材料体系,主要包括金属、聚合物、陶瓷及其复合材料。并从力学、生物相容性、生物可降解性、抗菌性、生物敏感性和磁致伸缩性等方面系统地讨论了复合材料在多种性能上的协同效应。其次,从优势、工艺、性能和应用等方面概述了增材制造在异质结构发展中的研究进展。本文还重点介绍了异质结构在生物医学领域的应用前景,特别是在生物支架、血管系统、生物传感器和生物检测方面。最后,展望异质结构未来的研究方向和突破,重点关注其在感染预防和药物传递方面更有前景的应用。
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引用次数: 2
Ultra-fast 3D printing of assembly—free complex optics with sub-nanometer surface quality at mesoscale 具有亚纳米级表面质量的无装配复杂光学元件的超快速3D打印
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-02 DOI: 10.1088/2631-7990/acdb0d
Shuai Peng, Jiawen Xu, Dongya Li, Jun Ren, Meng Zhang, Xiaolong Wang, Y. Liu
Complex-shaped optical lenses are of great interest in the areas of laser processing, machine vision, and optical communications. Traditionally, the processing of complex optical lenses is usually achieved by precision machining combined with post-grinding or polishing, which is expensive, labor-intensive and difficult in the processing of ultra-complex optical lenses. Additive manufacturing is an emerging technology that provides significant advantages in producing highly intricate optical devices. However, the layer-by-layer method employed in such manufacturing processes has resulted in low printing speeds, as well as limitations in surface quality. To address these challenges, we apply tomographic volumetric printing (TVP) in this work, which can realize the integrated printing of complex structural models without layering. By coordinating the TVP and the meniscus equilibrium post-curing methods, ultra-fast fabrication of complex-shaped lenses with sub-nanometric roughness has been achieved. A 2.5 mm high, outer diameter 9 mm spherical lens with a roughness value of RMS = 0.3340 nm is printed at a speed of 3.1 × 104 mm3 h−1. As a further demonstration, a complex-shaped fly-eye lens is fabricated without any part assembly. The designed spherical lens is mounted on a smartphone’s camera, and the precise alignments above the circuit board are captured. Upon further optimization, this new technology demonstrates the potential for rapid fabrication of ultra-smooth complex optical devices or systems.
复杂形状的光学透镜在激光加工、机器视觉和光通信等领域具有重要意义。传统上,复杂光学透镜的加工通常是通过精密加工结合后磨或抛光来实现的,在超复杂光学透镜的加工中,这种加工成本高、劳动强度大、难度大。增材制造是一种新兴技术,在生产高度复杂的光学器件方面具有显著的优势。然而,在这种制造过程中采用的逐层方法导致了低印刷速度,以及表面质量的限制。为了解决这些问题,我们在这项工作中应用了层析体积打印(TVP),它可以实现复杂结构模型的集成打印,而不需要分层。通过协调TVP和半月板平衡后固化方法,实现了亚纳米粗糙度复杂形状透镜的超快速加工。以3.1 × 104 mm3 h−1的速度打印出高2.5 mm、外径9 mm、粗糙度值RMS = 0.3340 nm的球面透镜。作为进一步的演示,在没有任何零件装配的情况下,制造了一个复杂形状的蝇眼透镜。设计的球形镜头安装在智能手机的摄像头上,并捕捉电路板上方的精确对齐。经过进一步优化,这项新技术展示了快速制造超光滑复杂光学器件或系统的潜力。
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引用次数: 1
A direct laser-synthesized magnetic metamaterial for low-frequency wideband passive microwave absorption 用于低频宽带被动微波吸收的直接激光合成磁性超材料
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-02 DOI: 10.1088/2631-7990/acdb0c
Yihe Huang, Yize Li, Kewen Pan, Yixian Fang, K. Chan, Xiaoyu Xiao, W. Chao, K. Novoselov, J. Gallop, L. Hao, Zhu Liu, Zhirun Hu, Lin Li
Microwave absorption in radar stealth technology is faced with challenges in terms of its effectiveness in low-frequency regions. Herein, we report a new laser-based method for producing an ultrawideband metamaterial-based microwave absorber with a highly uniform sheet resistance and negative magnetic permeability at resonant frequencies, which results in a wide bandwidth in the L- to S-band. Control of the electrical sheet resistance uniformity has been achieved with less than 5% deviation at 400 Ω sq−1 and 6% deviation at 120 Ω sq−1, resulting in a microwave absorption coefficient between 97.2% and 97.7% within a 1.56–18.3 GHz bandwidth for incident angles of 0°–40°, and there is no need for providing energy or an electrical power source during the operation. Porous N- and S-doped turbostratic graphene 2D patterns with embedded magnetic nanoparticles were produced simultaneously on a polyethylene terephthalate substrate via laser direct writing. The proposed low-frequency, wideband, wide-incident-angle, and high-electromagnetic-absorption microwave absorber can potentially be used in aviation, electromagnetic interference (EMI) suppression, and 5G applications.
雷达隐身技术中的微波吸收在低频区域的有效性面临着挑战。在此,我们报告了一种新的基于激光的方法来生产超宽带基于超材料的微波吸收剂,该方法在谐振频率下具有高度均匀的片电阻和负磁导率,从而在L到s波段具有较宽的带宽。在400 Ω sq - 1和120 Ω sq - 1处,电阻均匀性控制偏差分别小于5%和6%,在0°-40°入射角范围内,1.56 ~ 18.3 GHz带宽内的微波吸收系数在97.2% ~ 97.7%之间,且工作过程中不需要提供能量和电源。采用激光直接写入的方法,在聚对苯二甲酸乙二醇酯衬底上同时制备了嵌入磁性纳米颗粒的多孔N和s掺杂涡轮层石墨烯二维图形。所提出的低频、宽带、宽入射角和高电磁吸收的微波吸收器可以潜在地用于航空、电磁干扰(EMI)抑制和5G应用。
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引用次数: 1
A theoretical and deep learning hybrid model for predicting surface roughness of diamond-turned polycrystalline materials 基于理论和深度学习的多晶材料表面粗糙度预测模型
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-02 DOI: 10.1088/2631-7990/acdb0a
Chunlei He, Jiwang Yan, Shuqi Wang, Shuo Zhang, Guangsi Chen, C. Ren
Polycrystalline materials are extensively employed in industry. Its surface roughness significantly affects the working performance. Material defects, particularly grain boundaries, have a great impact on the achieved surface roughness of polycrystalline materials. However, it is difficult to establish a purely theoretical model for surface roughness with consideration of the grain boundary effect using conventional analytical methods. In this work, a theoretical and deep learning hybrid model for predicting the surface roughness of diamond-turned polycrystalline materials is proposed. The kinematic–dynamic roughness component in relation to the tool profile duplication effect, work material plastic side flow, relative vibration between the diamond tool and workpiece, etc, is theoretically calculated. The material-defect roughness component is modeled with a cascade forward neural network. In the neural network, the ratio of maximum undeformed chip thickness to cutting edge radius R TS, work material properties (misorientation angle θ g and grain size d g), and spindle rotation speed n s are configured as input variables. The material-defect roughness component is set as the output variable. To validate the developed model, polycrystalline copper with a gradient distribution of grains prepared by friction stir processing is machined with various processing parameters and different diamond tools. Compared with the previously developed model, obvious improvement in the prediction accuracy is observed with this hybrid prediction model. Based on this model, the influences of different factors on the surface roughness of polycrystalline materials are discussed. The influencing mechanism of the misorientation angle and grain size is quantitatively analyzed. Two fracture modes, including transcrystalline and intercrystalline fractures at different R TS values, are observed. Meanwhile, optimal processing parameters are obtained with a simulated annealing algorithm. Cutting experiments are performed with the optimal parameters, and a flat surface finish with Sa 1.314 nm is finally achieved. The developed model and corresponding new findings in this work are beneficial for accurately predicting the surface roughness of polycrystalline materials and understanding the impacting mechanism of material defects in diamond turning.
多晶材料在工业上有广泛的应用。其表面粗糙度对其工作性能有显著影响。材料缺陷,特别是晶界对多晶材料表面粗糙度的影响很大。然而,传统的分析方法很难建立考虑晶界效应的表面粗糙度的纯理论模型。在这项工作中,提出了一个理论和深度学习混合模型,用于预测金刚石车削多晶材料的表面粗糙度。从理论上计算了与刀具轮廓重复效应、工件材料塑性侧流、刀具与工件之间的相对振动等因素有关的运动学-动力学粗糙度分量。采用级联前向神经网络对材料缺陷粗糙度分量进行建模。在神经网络中,将最大未变形切屑厚度与切削刃半径之比R TS、工件材料性能(取向角θ g和晶粒尺寸dg)和主轴转速n s作为输入变量。将材料缺陷粗糙度分量设置为输出变量。为了验证所建立的模型,采用不同的加工参数和不同的金刚石刀具对搅拌摩擦加工制备的晶粒呈梯度分布的多晶铜进行了加工。与已有模型相比,该混合预测模型的预测精度有明显提高。在此模型的基础上,讨论了不同因素对多晶材料表面粗糙度的影响。定量分析了取向角和晶粒尺寸的影响机理。在不同的rts值下,观察到两种断裂模式,包括跨晶断裂和晶间断裂。同时,利用模拟退火算法得到了最优的工艺参数。在最佳切削参数下进行切削实验,最终获得了Sa为1.314 nm的平面光洁度。所建立的模型和相应的新发现有助于准确预测多晶材料的表面粗糙度,并有助于理解金刚石车削过程中材料缺陷的影响机理。
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引用次数: 1
Ceramic particles reinforced copper matrix composites manufactured by advanced powder metallurgy: preparation, performance, and mechanisms 先进粉末冶金制备的陶瓷颗粒增强铜基复合材料:制备、性能和机理
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-06-02 DOI: 10.1088/2631-7990/acdb0b
Yilei Yan, S. Kou, Hong-Yu Yang, S. Shu, F. Qiu, Qilong Jiang, Lai‐Chang Zhang
Copper matrix composites doped with ceramic particles are known to effectively enhance the mechanical properties, thermal expansion behavior and high-temperature stability of copper while maintaining high thermal and electrical conductivity. This greatly expands the applications of copper as a functional material in thermal and conductive components, including electronic packaging materials and heat sinks, brushes, integrated circuit lead frames. So far, endeavors have been focusing on how to choose suitable ceramic components and fully exert strengthening effect of ceramic particles in the copper matrix. This article reviews and analyzes the effects of preparation techniques and the characteristics of ceramic particles, including ceramic particle content, size, morphology and interfacial bonding, on the diathermancy, electrical conductivity and mechanical behavior of copper matrix composites. The corresponding models and influencing mechanisms are also elaborated in depth. This review contributes to a deep understanding of the strengthening mechanisms and microstructural regulation of ceramic particle reinforced copper matrix composites. By more precise design and manipulation of composite microstructure, the comprehensive properties could be further improved to meet the growing demands of copper matrix composites in a wide range of application fields.
已知掺杂陶瓷颗粒的铜基复合材料可以有效地增强铜的力学性能、热膨胀行为和高温稳定性,同时保持较高的导热性和导电性。这极大地扩展了铜作为一种功能材料在热传导元件中的应用,包括电子封装材料和散热器、电刷、集成电路引线框架。如何选择合适的陶瓷组分,充分发挥陶瓷颗粒在铜基体中的强化作用,是目前研究的重点。本文综述和分析了制备工艺和陶瓷颗粒的特性,包括陶瓷颗粒含量、尺寸、形貌和界面结合对铜基复合材料的透热性、导电性和力学性能的影响。并对相应的模型和影响机制进行了深入阐述。本文综述有助于深入了解陶瓷颗粒增强铜基复合材料的强化机理和微观组织规律。通过对复合材料微观结构进行更精确的设计和控制,可以进一步提高复合材料的综合性能,以满足铜基复合材料日益增长的广泛应用领域的需求。
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引用次数: 2
Robotic in situ bioprinting for cartilage tissue engineering 软骨组织工程机器人原位生物打印
IF 14.7 1区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2023-05-31 DOI: 10.1088/2631-7990/acda67
Yaxin Wang, R. Pereira, C. Peach, Boyang Huang, C. Vyas, P. Bartolo
Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain, mobility issues, and disability. Current surgical treatments have a limited capacity for efficacious cartilage repair, and long-term patient outcomes are not satisfying. Three-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue regeneration. However, conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage tissue. In situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional bioprinting. In this review, we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage regeneration. We outline existing clinical approaches and the utilization of robotic-assisted surgical systems. Handheld and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and presented. Finally, we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.
关节软骨损伤由创伤或退行性病变如骨关节炎引起,可导致严重疼痛、行动不便和残疾。目前的手术治疗对软骨的有效修复能力有限,患者的长期预后也不令人满意。三维生物打印已被用于制造生化和生物物理环境,旨在重现原生微环境,促进组织再生。然而,由于生物打印构建体的制造和植入以及它们与天然软骨组织的整合方面的挑战,传统的体外生物打印具有局限性。原位生物打印是一种将生物墨水直接输送到所需解剖部位的新策略,具有克服传统生物打印相关的主要缺点的潜力。在这篇综述中,我们重点介绍了机器人辅助原位生物打印手术系统在软骨再生方面的新进展。我们概述了现有的临床方法和利用机器人辅助手术系统。手持式和机器人辅助的原位生物打印技术,包括微创和非侵入性方法的定义和介绍。最后,我们讨论了软骨原位生物打印应用的挑战和潜在的未来前景。
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引用次数: 1
期刊
International Journal of Extreme Manufacturing
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