Journal of Biosafety and Biosecurity最新文献_第2页

Strengthening national biosafety capabilities and enhancing global biosafety governance 加强国家生物安全能力建设，加强全球生物安全治理

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2025-09-01 DOI: 10.1016/j.jobb.2025.09.001

Chao Shan, Yuan Zhiming

引用次数: 0

The association between TMPRSS2 gene rs2070788 and rs12329760 variants and COVID-19 susceptibility and severity: A study from Jordan 来自约旦的TMPRSS2基因rs2070788和rs12329760变异与COVID-19易感性和严重程度的关系

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2025-09-01 DOI: 10.1016/j.jobb.2025.08.003

Sara S.H. Abu Zaid , Omar F. Khabour , Sawsan Abuhammad

Symptoms of coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), range from asymptomatic to life-threatening, affecting the respiratory system and many other organs, and involved in SARS-CoV-2 pathogenesis, particularly its viral entry, is the enzyme transmembrane protease serine 2 (TMPRSS2). In response, in this study, polymorphisms in the TMPRSS2 gene (rs2070788 and rs12329760) were examined for their association with COVID-19 susceptibility and severity in Jordanians. The study participants (n = 861) included 427 individuals who had never contracted COVID-19 (control group) and 434 who had experienced the disease (case group). The case group was subsequently divided into two subgroups: severe (n = 166) and non-severe (n = 268) COVID-19. The results show that rs2070788 is associated with disease susceptibility in all inheritance models (P < 0.05), as well as an association between rs12329760 and COVID-19 disease severity in both the dominant and over-dominant models (P < 0.05). Further, a higher body mass index (BMI) and older age were associated with disease severity (p < 0.05), though females were less likely to develop severe COVID-19 and to be hospitalized. In conclusion, polymorphisms in the TMPRSS2 gene may be considered a potential predictor of COVID-19 outcomes in the Jordanian population. The study findings could be used to manage similar viral infections in Jordan in the future.

由严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）引起的2019年冠状病毒病（COVID-19）的症状从无症状到危及生命不等，影响呼吸系统和许多其他器官，并且参与SARS-CoV-2的发病机制，特别是其病毒进入酶是跨膜蛋白酶丝氨酸2 （TMPRSS2）。为此，本研究检测了约旦人TMPRSS2基因（rs2070788和rs12329760）多态性与COVID-19易感性和严重程度的关系。研究参与者（n = 861）包括427名从未感染过COVID-19的人（对照组）和434名经历过这种疾病的人（病例组）。病例组随后被分为两个亚组：重症（n = 166）和非重症（n = 268） COVID-19。结果显示，rs2070788在所有遗传模型中均与疾病易感性相关（P < 0.05）， rs12329760在显性和过显性模型中均与COVID-19疾病严重程度相关（P < 0.05）。此外，较高的身体质量指数（BMI）和年龄与疾病严重程度相关（p < 0.05），尽管女性发展为严重的COVID-19和住院的可能性较低。总之，TMPRSS2基因的多态性可能被认为是约旦人群中COVID-19结局的潜在预测因子。研究结果可以用于未来在约旦管理类似的病毒感染。

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引用次数: 0

Scientometric analysis of research on deliberate biosecurity threats reveals North-Transatlantic dominance 对蓄意生物安全威胁研究的科学计量学分析揭示了北大西洋的主导地位

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2025-06-01 DOI: 10.1016/j.jobb.2025.04.002

Suryesh Kumar Namdeo, Chandan GN

Academic research is crucial to understanding and preparing for the fight against deliberate biological threats; yet, existing efforts have been fragmented, necessitating a more comprehensive examination of the field’s evolution. This study presents a scientometric analysis of deliberate biosecurity threats over the last 20 years, focusing on publication patterns, collaboration dynamics, research priorities, and leading publication venues. We analyzed 791 articles published between 2004 and 2023 using the Web of Science and Scopus databases. Results indicate a notable increase in publications dominated by North-Transatlantic countries, particularly the United States and the United Kingdom, which prioritize such areas as dual-use technology, synthetic biology, and virus-related biosecurity challenges. A comparative analysis of G7 and BRICS collaborations underscores substantial disparities in research output, with the G7 leading in international biosecurity research collaborations. Furthermore, the study reveals limited biosecurity research and collaboration in the Global South. Therefore, we encourage further exploration of biosecurity research to promote inclusive and collaborative global efforts. This study provides valuable insights for researchers and policymakers regarding biosecurity research priorities related to deliberate threats, and it highlights the need to address global disparities.

学术研究对于理解和准备打击蓄意的生物威胁至关重要；然而，现有的努力是分散的，需要对该领域的演变进行更全面的审查。本研究对过去20年蓄意的生物安全威胁进行了科学计量分析，重点关注出版模式、合作动态、研究重点和主要出版场所。我们使用Web of Science和Scopus数据库分析了2004年至2023年间发表的791篇文章。结果表明，以北大西洋国家，特别是美国和联合王国为主导的出版物显著增加，这些国家优先考虑军民两用技术、合成生物学和与病毒有关的生物安全挑战等领域。对七国集团和金砖国家合作的比较分析表明，七国集团在国际生物安全研究合作方面处于领先地位，在研究产出方面存在巨大差距。此外，该研究还揭示了发展中国家在生物安全方面的研究和合作有限。因此，我们鼓励进一步探索生物安全研究，以促进包容和合作的全球努力。这项研究为研究人员和政策制定者提供了有关蓄意威胁的生物安全研究重点的宝贵见解，并强调了解决全球差异的必要性。

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引用次数: 0

Impact of GO and ITO nanostructures’ performance on the nanostructure and optical behavior of a newly fabricated blended-PPY conductive polymer for antibacterial applications 氧化石墨烯和ITO纳米结构对新型聚吡咯导电聚合物纳米结构和光学性能的影响

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2025-06-01 DOI: 10.1016/j.jobb.2025.06.002

Rand Waleed, Ehssan Al-Bermany

Hybrid nanomaterials are attracting growing attention for their ability to improve the functional performance of polymer-based systems, making them strong contenders for advanced applications in the electronics and biomedical fields. In this study, novel hybrid nanocomposites were developed based on a polyvinylpyrrolidone (PVP) K30 matrix blended with the conductive polymer polypyrrole (PPy) and reinforced with graphene oxide (GO) and indium tin oxide (ITO) nanoparticles. The nanocomposites were fabricated using a solution-casting technique, with improved dispersion achieved through mechanical stirring and ultrasonication. Field emission scanning electron microscope (FESEM) images revealed a smooth surface morphology and an homogeneous distribution of nanomaterials within the polymer matrix. Meanwhile, Fourier transform infrared spectroscopy (FTIR) indicated strong physical interactions between the composite components, with X-ray diffraction confirming the semicrystalline behavior of PVP, which was strongly impacted by the contribution of the nanomaterials. UV–Vis spectroscopy showed significantly enhanced optical behavior, with a notable reduction in the optical band gap from ∼3.43 to 1.63 eV, indicating improved electronic transition efficiency. Furthermore, the well-dried solid films exhibited superior antibacterial activity, with inhibition zones increasing by 53.8% against Staphylococcus aureus and 46.1% against Escherichia coli. These findings highlight the novelty and multifunctionality of the developed nanocomposites, demonstrating their strong potential for use in flexible optical-electronics devices, antibacterial coatings, tissue engineering, and sensor applications and addressing current societal needs in the health, environmental, and medical sectors.

杂化纳米材料因其改善聚合物基体系功能性能的能力而受到越来越多的关注，使其成为电子和生物医学领域先进应用的有力竞争者。在这项研究中，基于聚乙烯吡咯烷酮（PVP） K30基体与导电聚合物聚吡咯（PPy）共混，并以氧化石墨烯（GO）和氧化铟锡（ITO）纳米颗粒增强，开发了新型杂化纳米复合材料。采用溶液铸造技术制备纳米复合材料，并通过机械搅拌和超声波改善了分散效果。场发射扫描电镜（FESEM）图像显示，聚合物基体表面形貌光滑，纳米材料分布均匀。同时，傅里叶变换红外光谱（FTIR）表明复合组分之间存在强烈的物理相互作用，x射线衍射证实PVP的半晶行为，这受到纳米材料的贡献的强烈影响。UV-Vis光谱显示出明显增强的光学行为，光学带隙从~ 3.43 eV显著减小到1.63 eV，表明电子跃迁效率提高。干燥后的固体膜对金黄色葡萄球菌和大肠杆菌的抑制面积分别提高了53.8%和46.1%。这些发现突出了所开发的纳米复合材料的新颖性和多功能性，展示了它们在柔性光电器件、抗菌涂层、组织工程和传感器应用以及解决当前健康、环境和医疗领域的社会需求方面的强大潜力。

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引用次数: 0

What are desirable biosecurity trainings for veterinary practitioners and farmers? 兽医从业人员和农民需要接受哪些生物安全培训？

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2025-06-01 DOI: 10.1016/j.jobb.2025.06.003

Anna Maria Iatrou , Blerta Mehmedi Kastrati , Rreze M. Gecaj , Georgios Batikas , Jarkko K. Niemi , Claude Saegerman , Alberto Oscar Allepuz , Wiebke Jansen , Nancy De Briyne , Daniele De Meneghi , Murat Yılmaz , Evelien Biebaut , Ramazan Yildiz , Marco De Nardi , Carla Correia-Gomes , Tarmo Niine

Effective biosecurity training is essential for disease prevention in livestock systems; however, substantial gaps persist. We combined an online survey (74 fully completed questionnaires; 267 views) with two World Café workshops (∼60 participants) to map the current provision, competence levels, and training needs across Europe. Key findings: (i) self-rated biosecurity knowledge differed markedly between stakeholder groups and veterinarians and other stakeholders reported median scores close to 80/100; (ii) more than three-quarters of cattle (77 %) and 70 % of swine veterinarians perceived a major gap in their ability to demonstrate the economic benefits of biosecurity to clients; (iii) 39 – 44 % of cattle and small-ruminant veterinarians reported inadequate mixed (theory + practice) training formats, and up to 50 % of poultry veterinarians identified deficits in communication and behavior-change skills; (iv) across all discussions, participants favored modular, blended delivery that couples concise e-learning with on-farm coaching, supported by externally audited certification and greater farmer co-design. Therefore, recommendations focus on developing species-specific, flexible modules that embed communication and cost-benefit elements, provide micro-learning units for time-constrained farmers, and operate within a tiered certification framework linked to continuing professional development. Implementing these measures will narrow competence gaps, strengthen veterinarian–farmer engagement, and enhance disease preparedness throughout European livestock production.

有效的生物安全培训对牲畜系统的疾病预防至关重要；然而，巨大的差距仍然存在。我们结合了在线调查(74份完整填写的问卷；267个视图)与两个世界咖啡研讨会（约60名参与者）一起绘制欧洲目前的供应、能力水平和培训需求。主要发现：(i)利益相关者群体之间自评生物安全知识差异显著，兽医和其他利益相关者报告的中位数得分接近80/100；（ii）超过四分之三的牛兽医（77%）和70%的猪兽医认为，他们在向客户证明生物安全的经济效益方面存在重大差距；（iii） 39% - 44%的牛和小反刍动物兽医报告说，混合（理论+实践）培训形式不足，高达50%的家禽兽医发现在沟通和行为改变技能方面存在缺陷；（iv）在所有的讨论中，参与者都倾向于模块化、混合式交付，将简洁的电子学习与农场指导结合起来，并辅以外部审计认证和更多的农民共同设计。因此，建议的重点是开发特定品种的灵活模块，这些模块包含沟通和成本效益要素，为时间有限的农民提供微型学习单元，并在与持续专业发展相关的分层认证框架内运行。实施这些措施将缩小能力差距，加强兽医农民的参与，并在整个欧洲畜牧生产中加强疾病防范。

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引用次数: 0

Antibacterial and anticancer potentials of graphene-silicon nitride nanomaterials-enhanced polymer nanocomposites: advanced characterization and optical behavior insights 石墨烯-氮化硅纳米材料增强聚合物纳米复合材料的抗菌和抗癌潜力：先进的表征和光学行为见解

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2025-05-12 DOI: 10.1016/j.jobb.2025.04.001

Rawaa A. Abdul-Nabi , Ehssan Al-Bermany

Hybrid nanomaterials (HNMs) have become more interesting to researchers for various optoelectronic and biological applications. In response, this investigation focuses on the impact of loading ratios of (0, 1 %, 3 %, and 5 %) of HNMs from graphene oxide (GO) and silicon nitride (Si₃N₄). HNMs are utilized to reinforce blended polymers, including polyethylene oxide (PEO), carboxymethyl cellulose (CMC), and nano-polyaniline (PANI) to fabricate (PEO_100K–CMC–PANI/GO–Si₃N₄) using the developed sol–gel-ultrasonic procedure. X-ray diffraction revealed semi-crystalline behavior among all samples, while Fourier transform infrared spectroscopy showed strong physical interfacial interactions among the sample components. Meanwhile, field emission scanning electron and transmission electron microscopies showed a fine dispersion and a homogeneous matrix with significant changes. The optical absorption behavior revealed continuous high absorption peaks at 200–280-nm wavelengths, which strongly impacts (GO–Si₃N₄). Increases in concentration also strongly impact (GO–Si₃N₄), which results in an improved optical energy gap for the allowed and forbidden transitions from 3.5 eV for the blended polymer to 3 and 2.9 eV by increasing the HNM content. The contributions of HNMs notably enhance the ability to reduce the zones of the bacteria, especially Escherichia coli, from 18 to 26 mm. In effect, HNMs with a concentration higher than 5 % assist in inhibiting the growth of lung cancer (A549) cells. As such, these NCs present good optical behavior for multi-applications, such as biosensors and biological and optoelectronic devices.

杂化纳米材料（HNMs）在光电子和生物领域的应用越来越受到研究人员的关注。因此，本研究的重点是氧化石墨烯（GO）和氮化硅（Si3N4）的负载比（0,1%，3%和5%）的影响。采用溶胶-凝胶-超声工艺，利用hnm增强混合聚合物，包括聚氧聚乙烯（PEO）、羧甲基纤维素（CMC）和纳米聚苯胺（PANI），制备（PEO100K-CMC-PANI / GO-Si3N4）。x射线衍射分析显示样品具有半结晶行为，傅里叶变换红外光谱分析显示样品组分之间存在较强的物理界面相互作用。同时，场发射扫描电子显微镜和透射电子显微镜观察到弥散良好，基质均匀且变化明显。在200 ~ 280nm波长处呈现连续的高吸收峰，对（GO-Si3N4）有强烈的影响。浓度的增加也会对（GO-Si3N4）产生强烈影响，通过增加HNM含量，混合聚合物的允许和禁止跃迁的光能间隙从3.5 eV提高到3 eV和2.9 eV。hnm的贡献显著增强了将细菌，特别是大肠杆菌的区域从18 mm减少到26 mm的能力。实际上，浓度高于5%的hnm有助于抑制肺癌（A549）细胞的生长。因此，这些NCs具有良好的光学性能，可用于多种应用，如生物传感器、生物和光电子器件。

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引用次数: 0

Health security disparities in the Eastern Mediterranean Region: A comparative analysis using an integrated MCDM and clustering approach 东地中海地区卫生安全差距：使用综合MCDM和聚类方法的比较分析

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2025-03-01 DOI: 10.1016/j.jobb.2025.01.001

Adel A. Nasser , Abed Saif Ahmed Alghawli , S. Saleh , Amani A.K. Elsayed

Objectives

This study aimed to analyze and compare health security performance (HSP) between Gulf Cooperation Council and non-Gulf Cooperation Council countries within the Eastern Mediterranean Region (EMR) for 2019 and 2021, recognizing the critical role of health security in managing global health threats.

Methods

The study utilized data from the Global Health Security Index (GHSI) for 2019 and 2021. Key health security priorities were identified using the entropy objective weighting method. The VIKOR (VIseKriterijumska Optimizacija I Kompromisno Resenje) method was employed to rank countries based on overall performance. K-means clustering was applied to group countries with similar health security profiles. Pearson’s and Spearman’s rank correlation coefficients were used to assess relationships between independent HSP indicators and overall performance scores.

Results

A significant shift in health security priorities within the EMR was observed between 2019 and 2021, with prevention gaining prominence. Gulf Cooperation Council countries emphasized detection and reporting, while non-Gulf Cooperation Council countries prioritized health systems and prevention. Gulf Cooperation Council countries, particularly Qatar and Saudi Arabia, consistently demonstrated strong HSP. Conversely, non-Gulf Cooperation Council countries facing conflict and instability, such as Yemen, Somalia, and Syria, exhibited weaker performance. Health system capacity, prevention, detection and reporting, and risk environment showed robust correlations with overall HSP.

Conclusion

This study underscores the necessity for tailored, adaptive policies to address HSP disparities across regions, highlighting investment in prevention, detection, and reporting. It stresses international collaboration, improved policy implementation, and ongoing research to enhance global health security systems across diverse contexts.

本研究旨在分析和比较2019年和2021年东地中海地区（EMR）海湾合作委员会和非海湾合作委员会国家的卫生安全绩效（HSP），认识到卫生安全在管理全球卫生威胁方面的关键作用。方法本研究利用2019年和2021年全球健康安全指数（GHSI）的数据。采用熵目标加权法确定了关键卫生安全优先事项。采用VIKOR （VIseKriterijumska Optimizacija I Kompromisno Resenje）方法根据总体表现对国家进行排名。将k均值聚类应用于具有相似卫生安全概况的分组国家。Pearson’s和Spearman’s等级相关系数用于评估独立HSP指标与总体表现得分之间的关系。结果在2019年至2021年期间，EMR的卫生安全重点发生了重大变化，预防变得更加重要。海湾合作委员会国家强调检测和报告，而非海湾合作委员会国家优先考虑卫生系统和预防。海湾合作委员会（Gulf Cooperation Council）成员国，尤其是卡塔尔和沙特阿拉伯，一直表现出很强的HSP。相反，面临冲突和不稳定的非海湾合作委员会国家，如也门、索马里和叙利亚，表现较弱。卫生系统能力、预防、发现和报告以及风险环境与总体HSP存在显著相关性。本研究强调有必要制定量身定制的适应性政策，以解决不同地区之间的HSP差异，强调在预防、检测和报告方面的投资。它强调国际合作、改进政策实施和正在进行的研究，以加强不同背景下的全球卫生安全系统。

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引用次数: 0

Laboratory biosafety risk assessment: A critical component of avian influenza preparedness 实验室生物安全风险评估：禽流感防范的一个重要组成部分

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2025-03-01 DOI: 10.1016/j.jobb.2025.02.001

Georgia McCluskey , Ann Cornish , Ian G. Barr, Chuan Kok Lim

引用次数: 0

Adherence to biosafety and biosecurity protocols: An assessment of biomedical and veterinary laboratories in Benin 遵守生物安全和生物安保议定书：对贝宁生物医学和兽医实验室的评估

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2024-12-17 DOI: 10.1016/j.jobb.2024.11.001

Philippe Sessou , Nestor Noudeke , Yves Eric Denon , Aretas Tonouhewa , Alban Zohoun , Nassirou Boukary , Désirée Metodakou , Brian Samuelson , Dana Hag Hamed , Jenny Zhao , Sumegha Asthana , Mohammed Abid , Erin M. Sorrell

Diagnostic laboratories play a crucial role in surveillance and epidemic preparedness. However, gaps in adherence to biosecurity and biosafety protocols in managing, isolating, storing, and disposing of infectious pathogens in these facilities pose a serious risk to the laboratory, local populations, and the surrounding environment. In this study, we evaluated adherence to biosecurity and biosafety protocols in 96 public and private biomedical and veterinary laboratories in Benin to identify and address such gaps. We followed a cross-sectional study design. We used the Biosafety and Biosecurity in Laboratory Tool to assess biomedical laboratories and the Laboratory Mapping Tool to assess veterinary laboratories. Data were collected using KoBoCollect and analyzed with R software version 4.0.5. Descriptive analysis, the chi-squared test, and logistic regression were used to analyze the data. The findings revealed that most laboratories did not comply with established guidelines. Of all laboratories surveyed, 42% presented a very high risk, 38% a high risk, 15% moderate risk, and 5% were low risk. Overall, 80% of biomedical laboratories and 100% of veterinary laboratories were rated high risk. To improve effective biosecurity practices in laboratories in Benin to an acceptable standard, it is essential to implement robust biosecurity and biosafety policies. Additionally, capacity-building sessions should be conducted for laboratory staff and managers to educate them on the latest biosecurity protocols.

诊断实验室在监测和流行病防范方面发挥着关键作用。然而，在这些设施中管理、隔离、储存和处置感染性病原体方面，在遵守生物安全和生物安全规程方面存在差距，这对实验室、当地人群和周围环境构成严重风险。在这项研究中，我们评估了贝宁96个公共和私人生物医学和兽医实验室对生物安全和生物安全协议的遵守情况，以确定和解决这些差距。我们采用了横断面研究设计。我们使用实验室的生物安全和生物安全工具来评估生物医学实验室，使用实验室测绘工具来评估兽医实验室。使用KoBoCollect收集数据，并使用R 4.0.5版软件进行分析。采用描述性分析、卡方检验和logistic回归对数据进行分析。调查结果显示，大多数实验室没有遵守既定的指导方针。在所有被调查的实验室中，42%的实验室存在非常高的风险，38%的实验室存在高风险，15%的实验室存在中等风险，5%的实验室存在低风险。总体而言，80%的生物医学实验室和100%的兽医实验室被评为高风险。为了将贝宁实验室的有效生物安全实践提高到可接受的标准，必须实施强有力的生物安全和生物安全政策。此外，应该为实验室工作人员和管理人员举办能力建设会议，教育他们了解最新的生物安全规程。

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引用次数: 0

Corrigendum to “Effectiveness of chemical inactivation of infectious liquid biological waste: A randomized sample study of research laboratories in Switzerland” [J. Biosaf. Biosecur. 6(1) (2024) 16–26] “传染性液体生物废物化学灭活的有效性：瑞士研究实验室的随机抽样研究”[J]。Biosaf。生物安全。6(1)(2024)16-26]

Q1 Social Sciences

Journal of Biosafety and Biosecurity

Pub Date : 2024-12-01 DOI: 10.1016/j.jobb.2024.09.001

Alina C. Teuscher , Charlotte Ruhnau , Nicole Stöcklin , Fabienne Wichmann , Evelyn Ilg Hampe , Claudia Bagutti

引用次数: 0