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The correlation of nutritional status with hematology toxicity of adjuvant chemotherapy in ovarian cancer 营养状况与卵巢癌症辅助化疗血液学毒性的相关性
Pub Date : 2021-09-14 DOI: 10.20473/mog.v29i22021.57-62
Kadek Dharma Widhiarta, B. Askandar
HIGHLIGHTS1. This retrospective cohort study found an increase in the diagnosis of malnutrition between the IMT method and NRI.2. A significant correlation was found between preoperative malnutrition and the incidence of anaemia after adjuvant chemotherapy for ovarian cancer patients.3. There were no significant correlations in this study in the incidence of leukopenia and thrombocytopenia.ABSTRACTObjectives: To observe correlation of nutritional status using Nutritional Risk Index with the side effects of adjunctive haematological chemotherapy.Materials and Methods: This study was a retrospective cohort study observing whether or not hematologic side effects occurred during chemotherapy based on medical records of postoperative ovarian cancer patients receiving adjuvant chemotherapy.Results: Sixty-eight subjects with age range of 31-50 years (44.1%) multipara (68.8%), and advanced stage (52.1%) were observed. An increase was found in the diagnosis of malnutrition between the IMT method and NRI, which was 18.7% compared to 43.7%. A significant correlation was found between preoperative malnutrition and the incidence of anaemia after adjuvant chemotherapy for ovarian cancer patients (p=0.002). Whereas, in the event of leukopenia and thrombocytopenia, there were no significant correlations with p=0.675 and p=0.415, respectively.Conclusion: There was an increase in malnutrition rate with the use of NRI compared with BMI and there was a significant correlation between malnutrition and side effects of anaemia in patients with ovarian cancer who underwent surgery and continued with adjuvant chemotherapy. 
亮点1.这项回顾性队列研究发现,在IMT方法和NRI之间,营养不良的诊断有所增加。卵巢癌症患者术前营养不良与辅助化疗后贫血发生率有显著相关性。在本研究中,白细胞减少症和血小板减少症的发生率没有显著相关性。目的:应用营养风险指数观察营养状况与血液辅助化疗副作用的相关性。材料与方法:本研究是一项回顾性队列研究,根据癌症术后辅助化疗患者的病历,观察化疗期间是否发生血液学副作用。结果:68例受试者,年龄范围31-50岁(44.1%),经产妇(68.8%),晚期(52.1%)。IMT法和NRI对营养不良的诊断有所增加,分别为18.7%和43.7%。术前营养不良与卵巢癌症患者辅助化疗后贫血的发生率之间存在显著相关性(p=0.002)。而在白细胞减少和血小板减少的情况下,与p分别为0.675和0.415无显著相关性。结论:与BMI相比,NRI的使用使营养不良率增加,并且在接受手术并继续辅助化疗的卵巢癌症患者中,营养不良与贫血副作用之间存在显著相关性。
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引用次数: 0
Prenatal diagnostic and management of megacystis microcolon intestinal hypoperistalsis syndrome: A report on a rare case in Cipto Mangunkusumo Hospital, Jakarta, Indonesia 巨囊性微结肠肠道蠕动不足综合征的产前诊断和处理:印度尼西亚雅加达Cipto Mangunkusumo医院1例罕见病例报告
Pub Date : 2020-10-30 DOI: 10.20473/mog.v28i22020.93-98
Fita Maulina, Y. Purwosunu
Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (MMIHS) is a rare and the most severe form of functional intestinal obstruction in the newborn. The characteristic features of this congenital and fatal disease are abdominal distension, absent or decreased bowel peristalsis. Abdominal distension is a consequence of the distended, unobstructed urinary bladder with or without hydro nephrosis. Some previous reports have revealed that the typical antenatal sonographic findings are as follows: a greatly distended bladder, bilateral hydro nephrosis, and a normal amount of amniotic fluid; however, the antenatal diagnosis of this syndrome is occasionally difficult.
巨孢子虫微克隆肠蠕动不足综合征(MMIHS)是一种罕见且最严重的新生儿功能性肠梗阻。这种先天性致命疾病的特征是腹胀、肠蠕动缺失或减少。腹胀是膀胱扩张、通畅伴或不伴肾积水的结果。先前的一些报道显示,典型的产前超声检查结果如下:膀胱严重扩张,双侧肾积水,羊水量正常;然而,这种综合征的产前诊断有时很困难。
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引用次数: 0
Peripartum cardiomyopathy and its relationship with preeclampsia 围产期心肌病及其与子痫前期的关系
Pub Date : 2020-10-30 DOI: 10.20473/MOG.V28I22020.52-58
C. Susanto, K. E. Gumilar
Objectives: To know the characteristic of PPCM in RSUD Dr. Soetomo Hospital Surabaya and to know the relationship between PPCM and PE.Materials and Methods: This was a case control study. Data was obtained from medical record of 2843 patients within 2014-2015, divided into 2 groups, 19 patients with PPCM in a case group, and 2824 patients in control group. The statistical analysis used was Fisher exact test.Results: Peripartum cardiomyopathy patients were older compared to control group (32.21 ± 6.83 y.o vs 29.26 ± 6.45 y.o). The incidence of PPCM in our study was about 1 per 149 live births. Most cases were diagnosed antepartum (52.63%), and about 84.2% PPCM cases were also complicating with preeclampsia. The statistical analysis revealed that there was increase risk of PPCM if the pregnant women complicates PE during pregnancy, with Odds Ratio (OR) 20.679, p<0.05. The most common perinatal outcomes was Small for Gestational Age (SGA) babies (81.8%), whereas case fatality rate (CFR) in maternal was 15.7%.Conclusion: Although diagnosis of PPCM is still an exclusion diagnosis, we have to pay more attention to pregnant women complicating with preeclampsia, since preeclampsia can increase the risk of PPCM.
目的:了解RSUD患者PPCM的特点,探讨PPCM与PE的关系。材料和方法:这是一项病例对照研究。数据来源于2014-2015年2843例患者的病历,分为2组,病例组19例PPCM患者,对照组2824例患者。统计分析采用Fisher精确检验。结果:围生期心肌病患者年龄比对照组大(32.21±6.83 y.o vs 29.26±6.45 y.o)。在我们的研究中,PPCM的发生率约为每149例活产1例。多数病例在产前确诊(52.63%),约84.2% PPCM患者合并先兆子痫。统计学分析显示,妊娠期合并PE的孕妇发生PPCM的风险增加,优势比(OR)为20.679,p<0.05。最常见的围产期结局是胎龄小(SGA)婴儿(81.8%),而产妇病死率(CFR)为15.7%。结论:虽然PPCM的诊断仍是一种排除性诊断,但由于子痫前期可增加PPCM的发病风险,我们必须对孕妇合并子痫前期给予更多的关注。
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引用次数: 0
HPV vaccine development after more than ten years approval 批准十多年后的HPV疫苗开发
Pub Date : 2020-06-26 DOI: 10.20473/mog.v28i12020.39-43
B. Askandar
At present, ten years have passed since the human papillomavirus (HPV) vaccine was first approved for use in humans. Research related to HPV vaccine, both in terms of effectiveness and immugenicity in its development, has been widely carried out, such as in terms of the indications of the HPV vaccine use that is not only for preventing cervical cancer, the guidelines for administering 2-dose HPV vaccines for those under 15 years of age, and the discovery of the latest HPV vaccine types: nonavalent HPV vaccine. This review literature discusses all aspects of the development of HPV vaccine since it was first approved for use in humans in 2006.
目前,人类乳头瘤病毒(HPV)疫苗首次被批准用于人类已经过去了十年。有关人乳头瘤病毒疫苗在研制过程中的有效性和免疫原性的研究已广泛开展,例如人乳头瘤病毒疫苗的适应症(不只是预防子宫颈癌)、为15岁以下儿童接种两剂人乳头瘤病毒疫苗的指南,以及发现最新的人乳头瘤病毒疫苗类型:无价人乳头瘤病毒疫苗。这篇综述文献讨论了HPV疫苗自2006年首次批准用于人类以来发展的各个方面。
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引用次数: 1
Knowledge and behavior of Indonesian general practitioners on cervical cancer early detection 印尼全科医生对子宫颈癌早期检测的知识和行为
Pub Date : 2020-06-26 DOI: 10.20473/mog.v28i12020.20-23
L. Nuranna, Nessyah Fatahan, A. Laily, G. Purwoto
Objective: Outline the correlation between cervical cancer-related knowledge and voluntary enrollment on early detection of cervical cancer.Material and Methods: Cross sectional design was performed. The inclusion is general practitioner women which currently married. Knowledge and behavior were assessed using questionnaire.Results: Among 367 respondents who filled the questionnaire, 77.4% of them (284) satisfy the inclusion criteria. 56% has high knowledge, and 42.3% has adequate knowledge. Moreover, 62.7% subjects ever performed cervical cancer early detection to themselves; 39.8% with VIA (visual inspection with acetic acid) and 46.5% with Papsmear and/or HPV DNA. Proportion of no early detection history with low and adequate knowledge 1.9 and 1.5 times simultaneously higher than proportion of no early detection with high knowledge. There is no significant correlation between level of knowledge and early detection history.Conclusion: There was no significant correlation between the level of knowlegde and voluntary enrollment for early detection of cervical cancer for general practitioners in Indonesia.
目的:探讨宫颈癌相关知识与自愿入组早期发现宫颈癌症的相关性。材料和方法:进行横断面设计。包括目前已婚的全科医生妇女。使用问卷对知识和行为进行评估。结果:在367名填写问卷的受访者中,77.4%(284人)符合纳入标准。56%的人具有高知识,42.3%的人具有足够的知识。此外,62.7%的受试者曾对自己进行过宫颈癌症早期检测;VIA(醋酸目视检查)组为39.8%,巴氏涂片和/或HPV DNA组为46.5%。低知识和充分知识的无早期检测史比例同时是高知识无早期检测比例的1.9倍和1.5倍。知识水平与早期检测史之间没有显著相关性。结论:在印度尼西亚,全科医生早期检测宫颈癌症的知识水平与自愿登记之间没有显著相关性。
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引用次数: 0
The outcome of Manchester operation in cervical elongation patients with pelvic organ prolapse at Dr. Soetomo Hospital, Surabaya from January 2015 to June 2017 2015年1月至2017年6月在泗水Soetomo医生医院对伴有盆腔器官脱垂的宫颈延长患者进行曼彻斯特手术的结果
Pub Date : 2020-06-26 DOI: 10.20473/mog.v28i12020.24-31
M. Dani, Azami Denas Azinar, E. Kurniawati, Hari Paraton, Gatut Hardianto, T. H. S. Hadi
Objectives: the aim of this study is to report the outcome of Manchester operation in cervical elongation patients with pelvic organ prolapse at Dr. Soetomo Hospital, Surabaya from January 2015 to June 2017.Case Report: During January 2015 until June 2017 there were seven patients already performed Manchester operation, however only four patients routine control. In all four cases, three cases were obtained with cervical elongation with a pelvic organ prolap (POP) and one case with cervical elongation. Perform evaluation before and after operation by using questionnaire and inspection of POP-Q system. During the evaluation there was one case with repeated lump complaints diagnosed with a uterine prolap, while one of it was with a posterior compartment prolap, but the patient did not complain during the evaluation. Both of these patients refused to reoperate after evaluation.Conclusion: After Manchester operation in cervical elongation with POP had two cases with repeated prolapse. Questionnaires and POP-Q systems were used to diagnose and evaluate preoperative and postoperative Manchester.
目的:本研究的目的是报告2015年1月至2017年6月在泗水Soetomo医生医院对伴有盆腔器官脱垂的宫颈延长患者进行曼彻斯特手术的结果。病例报告:2015年1月份至2017年六月期间,已有7名患者进行了曼彻斯特手术,但只有4名患者进行常规对照。在所有四例病例中,三例因盆腔器官脱垂(POP)导致宫颈延长,一例因宫颈延长。通过问卷调查和POP-Q系统检查进行术前和术后评估。在评估过程中,有一例反复出现肿块主诉,诊断为子宫脱垂,而其中一例诊断为后室脱垂,但患者在评估期间没有主诉。两名患者在评估后均拒绝再次手术。结论:曼彻斯特手术治疗POP宫颈延长术后有2例复发性脱垂。问卷和POP-Q系统用于诊断和评估术前和术后曼彻斯特。
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引用次数: 1
The evidence for the influence of musical compositions during pregnancy to the structure and functions of the offsprings’ brain 孕期音乐作品对后代大脑结构和功能影响的证据
Pub Date : 2020-06-26 DOI: 10.20473/mog.v28i12020.44-51
H. T. Joewono
Objective: to compile studies in Surabaya on the effect of Mozart compositions during pregnancy on the number of the offsprings brain neuron, glia, BDNF, apoptotic neurons and, neuronal dendritic density. These series of studies aimed to develop environmental-enrichment model during pregnancy so we can have better brain for the next generation. Better brain means better capacity in processing information, solving the problems, and creating new solutions that depends on the number of neuron, glia, ratio glia/ neuron and synapses. We do believe in the motto of “From Neurons to Nation” Overview: There were 38 studies, in animal models except two in human subjects, all of them with control, prospective, and randomized. The first group consist of analyze the frequency, sequence, time, duration, gestational age, distant, and intensity of Mozart composition. The second group: try to analyze the mechanism and compare with variety of other compositions including other western music(Chopin, Beethoven, Blues, Jazz, Rock) and Indonesian music(Gamelan Jawa, Sunda, Bali, Pop, Religious). The third group: combine with nutrition, reverse sequence, involving cerebrum and cerebellum, and right-left hemisphere. There were no growth restricted, dead, and malformed offsprings in both groups. The BDNF expression, synapsin I expression, the number of neuron, number of  glia, and dendritic density of the exposed groups were higher than control. The neuronal apoptotic index were lower in the exposed groupsConclusions: Mozart compositions during pregnancy increased the BDNF, synapsin I,  number of neuron,  number of glia, dendritic density and, also decreased the neuronal apoptosis in offsprings’ brain
目的:在泗水编写关于妊娠期莫扎特作品对后代脑神经元、胶质细胞、BDNF、凋亡神经元和神经元树突密度的影响的研究。这一系列研究旨在开发妊娠期环境富集模型,以便我们为下一代拥有更好的大脑。更好的大脑意味着处理信息、解决问题和创造新解决方案的能力更强,这取决于神经元、神经胶质、神经胶质/神经元比例和突触的数量。我们相信“从神经元到国家”概述的座右铭:共有38项研究,在动物模型中进行,只有两项在人类受试者中进行,所有研究都是对照、前瞻性和随机的。第一组包括分析莫扎特作品的频率、顺序、时间、持续时间、胎龄、距离和强度。第二组:试图分析其机制,并与其他各种作品进行比较,包括其他西方音乐(肖邦、贝多芬、蓝调、爵士、摇滚)和印度尼西亚音乐(加梅兰·贾瓦、巽他、巴厘岛、流行、宗教)。第三组:配合营养,逆序,累及大脑和小脑,左右半球。两组均未发现生长受限、死亡和畸形的后代。暴露组的BDNF表达、突触素I表达、神经元数量、胶质细胞数量和树突密度均高于对照组。结论:妊娠期莫札特复方制剂可增加BDNF、突触素I、神经元数量、胶质细胞数量、树突状细胞密度,并可降低仔鼠脑内神经元凋亡
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引用次数: 1
Anemia in the first trimester is associated with anemia during pregnancy in Sidotopo Wetan Community Health Center, Surabaya 泗水Sidotopo Wetan社区卫生中心妊娠早期贫血与妊娠期贫血相关
Pub Date : 2020-06-26 DOI: 10.20473/mog.v28i12020.16-19
P. Prasetya, B. Winardi, Djohar Nuswantoro
Objective: To analyze association between anemia in the first trimester and preeclampsia during pregnancy in Sidotopo Wetan Community Health Center Surabaya.Materials and Methods: This study was a analytic case control study. The samples were 49 women with preeclampsia as case group and 49 women non-preeclampsia as control group. The data were secondary data collected from medical record of pregnancy women on Sidotopo Wetan Community Health Center Surabaya from January 2016 – Desember 2017. The analysis was done by Chi Square Statistics.Results: 79,6% women in preeclampsia group and 93.9% women in non-preeclampsia group was not anemia in the first trimester. There is association between anemia in the first trimester and preeclampsia during pregnancy in Sidotopo Wetan Community Health Center Surabaya (p = 0.037; OR = 3.932 (CI 95% = 1.010 – 15.303)).Conclusion: There is association between anemia in the first trimester and preeclampsia during preg-nancy in Sidotopo Wetan Community Health Center Surabaya.
目的:分析泗水Sidotopo Wetan社区卫生中心妊娠早期贫血与子痫前期的关系。材料与方法:本研究为分析性病例对照研究。49例先兆子痫妇女为病例组,49例非先兆子痫妇女为对照组。数据为2016年1月至2017年12月泗水Sidotopo Wetan社区卫生中心孕妇医疗记录收集的二次数据。分析是由卡方统计完成的。结果:79,6%的先兆子痫组妇女和93.9%的非先兆子痫组妇女妊娠早期无贫血。泗水Sidotopo Wetan社区卫生中心妊娠早期贫血与妊娠子痫前期之间存在关联(p = 0.037;Or = 3.932 (ci 95% = 1.010 - 15.303))。结论:泗水Sidotopo Wetan社区卫生中心孕妇妊娠早期贫血与子痫前期存在相关性。
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引用次数: 0
Plastics and its effect to women reproductive systems 塑料及其对妇女生殖系统的影响
Pub Date : 2020-06-26 DOI: 10.20473/mog.v28i12020.1-2
Pudji Lestari
Since it was found in 1940’s, the use of plastic has become a habit, as it is convenient and cheap. It products in a world scale more than 300 million tonnes. What we have to pay for that convenience and cheapness is now obvious. The waste of plastic goods is everywhere. Nowadays, even in rural areas, plastic waste pollutes the environment. Even in the middle of the oceans, islands of plastic refuse are there in the currents.These garbages are deadly to marine life. Globally, we now discard about eight million tonnes of plastics. When it ends up in the seas, fish and turtles take it as a food, swallow it to death or die of starvation because what they have consumed is not real food.
自从它在20世纪40年代被发现以来,使用塑料已经成为一种习惯,因为它既方便又便宜。它的产品在世界范围内超过3亿吨。我们为这种方便和廉价所付出的代价现在是显而易见的。塑料制品的垃圾随处可见。如今,即使在农村地区,塑料垃圾也会污染环境。即使在海洋中央,洋流中也有塑料垃圾岛。这些垃圾对海洋生物是致命的。在全球范围内,我们现在丢弃了大约800万吨塑料。当它最终落入大海时,鱼和海龟会把它当作食物,吞下致死或饿死,因为它们吃的不是真正的食物。
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引用次数: 1
Classifying cesarean section using Robson Classification: An Indonesian tertiary hospital survey 用Robson分类法对剖宫产进行分类:印度尼西亚三级医院调查
Pub Date : 2019-09-19 DOI: 10.20473/mog.v27i22019.66-70
Ali A Sungkar, B. Santoso, Raymond Surya, Adly N.A. Fattah
Objectives: Cesarean delivery rates have increased remarkably and cause a major public health concern. This study aims to evaluate the feasibility of using the Robson Ten Group Classification System (TGCS) for cesarean delivery (CD) indications at institutional level.Materials and Methods: Database of all women delivering at Cipto Mangunkusumo Hospital, Jakarta, Indonesia were analayzed. The CD rates overall and in each Robson group were calculated, as was the contribution of each group to the overall CD rate. In addition, the CD indications in each group were analyzed.Results: Approximately almost half (48.04%) of women delivered by CS in our study. Groups 10 was the largest groups representing 27.82% of the obstetric population. The second and third largest were group 3 and 1, which represents 18.00% and 17.34%, respectively. The highest relatively contribution of CS rate were group 10, 1, and 3 with the percentage of 28.24%, 17.59%, and 15.19%; contributively.Conclusion: The TGCS can be applied at institutional level. It helps in planning strategies for specific subgroups of women to reduce CS rate and improve outcomes.
目的:剖宫产率显著上升,引起了公众的极大关注。本研究旨在评估在机构层面使用Robson十组分类系统(TGCS)用于剖宫产(CD)适应症的可行性。材料和方法:对印度尼西亚雅加达Cipto Mangunkusumo医院所有分娩妇女的数据库进行分析。计算总体和每个Robson组的CD发生率,以及各组对总体CD发生率的贡献。此外,还对各组的CD适应症进行了分析。结果:在我们的研究中,约有一半(48.04%)的女性通过CS分娩。第10组是最大的组,占产科人口的27.82%。第二和第三大是第3组和第1组,分别占18.00%和17.34%。CS发生率的相对贡献率最高的是第10组、第1组和第3组,分别为28.24%、17.59%和15.19%;贡献。结论:TGCS可以在制度层面得到应用。它有助于为特定的女性亚组制定战略,以降低CS发病率并改善结果。
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引用次数: 3
期刊
Majalah Obstetri dan Ginekologi
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