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Characteristics of gestational thropoblast tumor in Dr. Soetomo Hospital, year 2015-2017 2015-2017年Dr. Soetomo医院妊娠期血小板母细胞肿瘤的特点
Pub Date : 2019-09-19 DOI: 10.20473/mog.v27i22019.79-83
Y. A. Angelina, Poedjo Hartono
Objectives: To report the characteristics of the patients of Gestational Trophoblastic Neoplasia (GTN) and its management at Dr. Soetomo Hospital, Surabaya, Indonesia.Case Report: There were 41 cases GTN at dr. Soetomo hospital within 3 years, data were collected from January 2015 to December 2017, which are 11 cases develop drug resistance.Conclusion: GTN is a chemosensitive neoplasia but can also experience resistance to chemotherapy. It is important to monitor the levels of beta-HCG for at least 12 months before the patient can get pregnant again.
目的:报道印度尼西亚泗水Soetomo医生医院妊娠滋养细胞瘤(GTN)患者的特点及其处理。病例报告:2015年1月至2017年12月,dr. Soetomo医院3年内共有41例GTN病例,其中11例出现耐药。结论:GTN是一种化疗敏感性肿瘤,但对化疗也有耐药性。在患者再次怀孕之前,监测- hcg水平至少12个月是很重要的。
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引用次数: 2
FR 50% in pregnancy results in different neuron and glial cell count (astrocytes, olygodendrocytes, and microglia) in the cerebrum and cerebellum of newborn Rattus norvegicus 妊娠期fr50 %导致新生褐家鼠大脑和小脑中神经元和胶质细胞(星形胶质细胞、多束神经细胞和小胶质细胞)计数不同
Pub Date : 2019-09-19 DOI: 10.20473/mog.v27i22019.56-65
Fitria Desky, H. T. Joewono, W. Widjiati
Objectives: To analyze the difference neuronal and glial (astrocytes, oligodendrocyte, microglia) cell count in cerebrum and cerebellum of Rattus norvegicus newborns with 50% food restriction and control group.Materials and Methods: This was an analytical experimental study with single blind randomized post test only control group design using animals subjects Rattus norvegicus. This study was conducted at Animal laboratory, Veterinary Faculty, Universitas Airlangga. Animal subjects were divided into FR50% group and control. Neuron and glial (astrocytes, oligodendrocytes, microglia) counts were analyzed using comparison test, with CI 95%.Results: There was a significant difference in cerebrum and cerebellum neuron cell count between intervention and control group (9.88+3.59 vs 16.88+2.553; p=0.000 and 7.5+1.789 vs 11.44+4.56; p=0.02). There was no difference in cerebrum and cerebellum glial cell count. There was a significant difference in cerebellum astrocyte between intervention and control group (80.94+24.255 vs 59.69+18.77; p=0.02) but no difference in cerebrum. There was a significant difference in cerebrum and cerebellum oligodendrocyte between intervention and control group (14.06+12.195 vs 25.13+8.609; p<0.000 and 13.63+6.712 vs 24.00+8.862; p=0.001), and there were significant difference in cerebrum and cerebellum microglia cell between intervention and control group (5.25+3.435 vs 4.94+3.838; p=0.620 and 8.81+4.119 vs 5.25+1.483; p=0.004).Conclusion: Food Restriction 50% (FR50%) in Rattus norvegicus decreased cerebrum and cerebellum neuron cell and oligodendrocyte count and increased cerebrum and cerebellum microglial count.
目的:分析50%食物限制组和对照组褐家鼠新生儿大脑和小脑神经元和胶质细胞(星形胶质细胞、少突胶质细胞、小胶质细胞)计数的差异。材料和方法:这是一项分析性实验研究,采用单盲随机试验后对照组设计,使用动物受试者褐家鼠。这项研究是在Airlangga大学兽医学院动物实验室进行的。动物受试者被分为FR50%组和对照组。使用比较试验分析神经元和神经胶质细胞(星形胶质细胞、少突胶质细胞、小胶质细胞)计数,CI为95%。结果:干预组和对照组的大脑和小脑神经细胞计数有显著差异(9.88±3.59 vs 16.88±2.553;p=0.000和7.5±1.789 vs 11.44±4.56;p=0.02)。干预组和对照组的小脑星形胶质细胞有显著差异(80.94+24.255 vs 59.69+18.77;p=0.02),但大脑无差异。干预组和对照组的大脑和小脑少突胶质细胞有显著差异(14.06+12.195 vs 25.13+8.609;p<0.000和13.63+6.712 vs 24.00+8.862;p=0.001),干预组和对照组的大脑和小脑小胶质细胞数有显著性差异(5.25±3.435 vs 4.94±3.838;p=0.620和8.81±4.119 vs 5.25±1.483;p=0.004)。
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引用次数: 0
Trying to understand preeclampsia. A rocky road 试图了解先兆子痫。崎岖不平的道路
Pub Date : 2019-09-19 DOI: 10.20473/MOG.V27I22019.45-48
G. Dekker
This narrative is not a review, it is just a personal account of a series of pivotal studies that directly influenced my evolving research interest in the pathogenesis and prevention of preeclampsia since the early 1980s’.Studying in Leiden (The Netherlands) in the early 1970’s, my introduction into obstetrics was not very positive. The obstetrical teaching, we received, as 3rd year medical students was boring. The focus was very much on the individual plusses and minuses of types of obstetrical forceps. Preeclampsia was a disease caused by ‘salt excess’, strict salt restriction the key concept in prevention of preeclampsia in The Netherlands.One of my lecturers told us that disseminated intravascular coagulation (DIC) was the key causal pathophysiologic mechanism in preeclampsia. At this stage one did not realize that the ‘DIC’ observations were all based on autopsy findings in women dying of eclampsia and/or HELLP (although that acronym was only introduced by Weinstein1 in 1982). It was Prof Jack Pritchard2 who – already in these years – made the observation that we ‘never die alone – DIC is always there’. For me the ‘DIC’ lectures certainly triggered my interest in the haemostatic system.
这篇文章并不是一篇综述,它只是对一系列关键研究的个人叙述,这些研究直接影响了我自20世纪80年代初以来对先兆子痫发病机制和预防的研究兴趣。上世纪70年代初,我在莱顿(荷兰)学习时,对产科的了解并不十分积极。作为医科三年级的学生,我们接受的产科教学很无聊。重点是非常个人的优点和缺点的类型的产科钳。子痫前期是一种由“盐过量”引起的疾病,严格的盐限制是荷兰预防子痫前期的关键概念。我的一位讲师告诉我们,弥散性血管内凝血(DIC)是子痫前期的主要病理生理机制。在这个阶段,人们没有意识到“DIC”的观察结果都是基于死于子痫和/或HELLP的妇女的尸检结果(尽管这个首字母缩略词只是由温斯坦在1982年引入的)。杰克·普里查德(Jack pritchard)教授在几年前就提出了这样的观点:我们“永远不会孤独地死去——DIC永远存在”。对我来说,“DIC”讲座当然引发了我对止血系统的兴趣。
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引用次数: 1
Abdominal skin metastasis in endometrial cancer 子宫内膜癌的腹部皮肤转移
Pub Date : 2019-09-19 DOI: 10.20473/MOG.V27I22019.84-89
Eccita Rahestyningtyas, Pungky Mulawardhana, Tomy Lesmana
Objectives: Surgical wound metastases in stage 1 endometrial cancer are possible, with a variety of different pathophysiological possibilities. Comprehensive management is needed to keep the patient on the possibility of a good prognosis.Cases Report: During January 2015 – January 2018 at dr. Soetomo Hospital, there were 2 cases of metastatic endometrial cancer in the laparotomy wounds by which the condition is very rare. Case 1, The patient was diagnosed with endometrial carcinoma following the results of curettage. Anatomical pathology examination was done and obtained grade 2 endometrioid adenocarcinoma. In Case 2, the patient underwent Total Abdominal Hysterectomy and Bilateral Salpingo-Oophorectomy in 2013 at Mojokerto General Hospital, indicating Uterine Fibroids and Ovarian Cysts. The results of anatomical pathology examination were unknown. On April 2017, the patient complained abdominal swelling since 3 months ago.Conclusion: In January 2015 - January 2018, 2 cases of metastatic endometrial cancer was found in a former laparotomy operation where this condition is very rare in endometrial cancer cases with low grade ,so that follow-up, monitoring and more vigilance are required in patients with low-grade endometrial Ca who have finished undergoing a surgery and chemotherapy. Rapture or mass resection, followed by external radiation, may be performed in patients with recurrence in the laparotomy wound area or in patients with high risk factors for endometrial cancer such as a history of estrogen use, tamoxifen, nullipara, obesity, diabetes mellitus, and family history of endometrial cancer. Currently, there is no fixed procedure (guideline) in RS. Dr. Soetomo to overcome recurrences especially in the scars of cancer surgery.
目的:手术伤口转移在1期子宫内膜癌中是可能的,具有多种不同的病理生理可能性。需要综合管理,以保持患者良好预后的可能性。病例报告:2015年1月至2018年1月,在dr. Soetomo医院,有2例转移性子宫内膜癌在剖腹手术伤口,这种情况非常罕见。病例1:患者经刮宫检查诊断为子宫内膜癌。解剖病理检查为2级子宫内膜样腺癌。病例2于2013年在Mojokerto总医院行全腹子宫切除术和双侧输卵管卵巢切除术,诊断为子宫肌瘤和卵巢囊肿。解剖病理检查结果未知。患者于2017年4月主诉腹部肿胀3个月。结论:2015年1月- 2018年1月,既往剖腹手术中发现2例转移性子宫内膜癌,这种情况在低级别子宫内膜癌病例中非常罕见,因此对完成手术和化疗的低级别子宫内膜癌患者需要随访、监测和提高警惕。剖腹手术创面复发的患者,或有雌激素、他莫昔芬、子宫内膜癌、肥胖、糖尿病、子宫内膜癌家族史等子宫内膜癌高危因素的患者,均可行剖腹手术或肿块切除后行外放射线治疗。目前,RS. Dr. Soetomo没有固定的程序(指南)来克服复发,特别是在癌症手术的疤痕。
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引用次数: 2
Pattern of disease and type of operation of Surgical Site Infection in obstetrics and gynecology at Dr Soetomo Hospital, Surabaya, Indonesia 印度尼西亚泗水Soetomo医生医院妇产科手术部位感染的疾病模式和手术类型
Pub Date : 2019-09-19 DOI: 10.20473/mog.v27i22019.49-55
Ardi Eko Marsanto, K. Kuntaman, Hari Paraton, B. Prasetyo
Objectives: to find correlation between risk factors and classification of SSI, the distribution of SSI, and cost in Soetomo Hospital.Materials and Methods: descriptive retrospective observational with correlation analysis between risk factors and SSI classification according to Centers for Disease Control (CDC) definition with univariate analysis. Sub-group descriptive analysis on microbiology result, length of stay (LOS) and cost was also performed. All patients was diagnosed SSI between January 2015 until June 2017.Results: age, referral cases, Body Mass Index, Hemoglobin and Albumin results, types of surgery, types of case are the risk factors we included. Analysis result shows no strong and significance correlation in all risk factors (r 0.053 – 0.447; p 0.072 – 0.971). According to SSI types, the distribution are: superficial (7; 13.2%), deep (26; 49.1%), organ/space (20; 37.7%). Extended-Spectrum Beta-Lactamase (ESBL) was obtained in 19 (14 Obstetrics; 5 Gynecology) from 28 patients with microbiology results. Five deaths occured in ESBL patients (1 Obstetrics; 4 Gynecology; ratio 1 : 11.2). Mean length of stay in Obstetrics and Gynecology was 41.7 and 19.2 days, respectively. Mean cost per day in Obstetrics and Gynecology was 1.2 amd 2.6 million rupiah, respectively.Conclusions: no strong and significant results in all risk factors. Death rate in SSI and malignancy with positive ESBL result are high. Less cost needed for SSI patients, but with longer LOS. Comprehensive approaches are needed to patients at risk of SSI, further study with larger sample are needed.
目的:了解Soetomo医院SSI分类、SSI分布和费用与危险因素之间的相关性。材料和方法:描述性回顾性观察,根据疾病控制中心(CDC)的定义,单变量分析危险因素与SSI分类之间的相关性分析。还对微生物学结果、住院时间(LOS)和费用进行了分组描述性分析。所有患者在2015年1月至2017年6月期间被诊断为SSI。结果:年龄、转诊病例、体重指数、血红蛋白和白蛋白结果、手术类型、病例类型是我们纳入的风险因素。分析结果显示,所有风险因素之间没有强而显著的相关性(r 0.053–0.447;p 0.072–0.971)。根据SSI类型,分布为:浅表型(7;13.2%)、深表型(26;49.1%)、器官/空间型(20;37.7%)。19名(14名产科;5名妇科)患者获得了扩展谱β-内酰胺酶(ESBL),并有微生物学结果。ESBL患者中有5例死亡(产科1例,妇科4例,比例1:11.2)。产科和妇科的平均住院时间分别为41.7和19.2天。妇产科每天的平均费用分别为120万卢比和260万卢比。结论:在所有危险因素中没有强有力且显著的结果。SSI和ESBL阳性的恶性肿瘤的死亡率较高。SSI患者所需费用较低,但服务水平较长。需要对有SSI风险的患者采取全面的方法,需要对更大样本进行进一步研究。
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引用次数: 2
Herlyn-Werner-Wunderlich Syndrome in pregnancy 妊娠期Herlyn-Werner奇妙综合征
Pub Date : 2019-09-19 DOI: 10.20473/mog.v27i22019.76-78
N. Ngan, Erry Gumilar Dahlan, E. Kurniawati
Objectives: To prevent Herlyn-Werner-Wunderlich syndrome’s complication in pregnancyCase Report: Presenting 2 cases pregnant with Herlyn-Werner Wunderlich syndrome, which is both of the case diagnosed at teenage and becoming pregnant then delivered by cesarean due to severe preeclampsia.Conclusion: High suspectious is needed to diagnose Herlyn-Werner-Wunderlich syndrome and early diagnosis is better prognosis. The gold standard diagnostic is MRI. The treatment is resection of the vaginal septum, drainage, and marsupialization. Preconception Counseling is important to prevent or to reduce the pregnancy complications.
目的:预防Herlyn-Werner-Wunderlich综合征的妊娠并发症病例报告:报告2例Herlyn-Werner-Wunderlich综合征孕妇,均为青少年确诊,因严重子痫前期妊娠后剖宫产。结论:诊断herlin - werner - wunderlich综合征需高度怀疑,早期诊断预后较好。金标准诊断是核磁共振成像。治疗方法是切除阴道间隔,引流和有袋化。孕前咨询对预防或减少妊娠并发症非常重要。
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引用次数: 1
Utilization of MCH handbooks and attitudes of pregnant women regarding pregnancy and childbirth complications 妇幼保健手册的使用情况及孕妇对妊娠和分娩并发症的态度
Pub Date : 2019-09-19 DOI: 10.20473/MOG.V27I22019.71-75
D. Irawati, Agustin Dwi Syalfina
Objectives: Maternal Mortality Rate (MMR) is closely related to maternal care. MMR in Indonesia based on the 2015 IDHS is 359 per 100,000 live births. By increasing the utilization of MCH handbooks, MMR would be decline. Therefore, this research investigated the relationship between of the utilization of MCH handbooks and attitudes pregnant women regarding pregnancy and childbirth complications.Materials and Methods: We conducted a cross sectional research with 54 pregnant women during March - June 2018 at the Sooko Health Center, Mojokerto. The independent variable was the utilization of MCH handbooks and the dependent variable was the attitude of pregnan women regarding pregnancy and childbirth complications. Data analysis included descriptive and bivariate analysis.Results: The results showed that 79.6% of respondents used the MCH handbook well. The results of the chi square analysis test showed a p value of 0.027 (<0.05).Conclusion: MCH handbook utilization effected the attitude of pregnant women regarding the complication of pregnancy and childbirth. Pregnant women who read and utilize MCH handbook would be have better alertness about the risk of complication so they would make the right decision for their pregnancy.
目的:孕产妇死亡率与孕产妇保健密切相关。根据2015年IDHS,印度尼西亚的MMR为每100000名活产359人。通过增加妇幼保健手册的使用,MMR将下降。因此,本研究调查了妇幼保健手册的使用情况与孕妇对妊娠和分娩并发症的态度之间的关系。材料和方法:2018年3月至6月,我们在莫乔克托的Sooko健康中心对54名孕妇进行了横断面研究。自变量是MCH手册的使用情况,因变量是孕妇对妊娠和分娩并发症的态度。数据分析包括描述性分析和双变量分析。结果:79.6%的受访者对妇幼保健手册使用情况良好。卡方分析结果显示p值为0.027(<0.05)。结论:妇幼保健手册的使用影响了孕妇对妊娠和分娩并发症的态度。阅读和使用妇幼保健手册的孕妇会对并发症的风险有更好的警惕性,从而为怀孕做出正确的决定。
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引用次数: 3
Mung bean sprout extract suppresses Monosodium Glutamate (MSG) effect on the reproductive hormones (FSH and Estrogen) in female Wistar rats 绿豆芽提取物抑制味精对雌性Wistar大鼠生殖激素(FSH和雌激素)的影响
Pub Date : 2019-05-23 DOI: 10.20473/MOG.V1I12019.24-27
Widati Fatmaningrum, W. Ningtyas
Objectives: The purpose of this study was to analyze the effects of mung bean sprout extracts on Follicle stimulating hormone (FSH) and estrogen hormone in female Wistar rats (Rattus norvegicus) exposed to monosodium glutamate (MSG).Materials and Methods: This true experimental study was conducted by using post-test only control group design in the laboratory for animal experimentation of Faculty of Veterinary Medicine - Airlangga University in which Wistar rats (Rattus norvegicus) aged 2 months weighing 150-200 grams were used in this experiment. The samples comprised of 5 rats distributed in each group, totaling 7 groups. I Control Group (P1) was provided with Aquades for 37 days; II (P2) was provided with Aquades for 7 days + MSG 0.03 mg/g of weight on day 8-37; III (P3) was provided with extract of mung bean sprouts 72mg/200g of weight on day 1-37 + MSG 0,03mg/g of weight; IV (P4) was provided with extract of mung bean sprouts 144mg/200g of weight on day 1-37 + MSG 0.03mg/g of weight; V (P5) was provided with Aquades for 7 days + MSG 0.7 mg/g of weight on day 8-37; VI (P6) was provided with extract of mung bean sprouts 72mg/200g of weight on day 1-37 + MSG 0.7mg/g of weight; VII (P7) was provided with extract of mung bean sprouts 144mg/200g of weight on day 1-37 + MSG 0.7mg/g of weight.Serum samples were taken for Follicle Stimulating Hormone (FSH) and Estrogen with ELISA method. Data analysis to test the differences between groups was done by using one way Anova statistical test.Results: MSG dosage 0,03mg/gBB or 0,7mg/g BB was significant difference in FSH (p = 0,011) and estrogen (p = 0,008).Conclusion: obtained from this research that giving green bean sprout extract influence to the level of FSH and estrogen hormone.
目的:分析绿豆芽提取物对谷氨酸(MSG)暴露雌性Wistar大鼠(褐家鼠)卵泡刺激素(FSH)和雌激素的影响Airlangga大学兽医学院,在该实验中使用了体重150-200克的2个月大的Wistar大鼠(褐家鼠)。样品由5只大鼠组成,每组分布,共7组。I对照组(P1)给予Aquades 37天;II(P2)在第8-37天用Aquades+MSG 0.03mg/g重量提供7天;在第1-37天向III(P3)提供72mg/200g重量的绿豆芽提取物+0,03mg/g重量的MSG;IV(P4)在第1-37天提供144mg/200g重量的绿豆芽提取物+0.03mg/g重量的MSG;V(P5)在第8-37天用Aquades+MSG 0.7mg/g重量提供7天;VI(P6)在第1-37天给予绿豆芽提取物72mg/200g重量+MSG 0.7mg/g重量;VII(P7)在第1-37天提供144mg/200g重量的绿豆芽提取物+0.7mg/g重量的MSG。采用ELISA法测定卵泡刺激素(FSH)和雌激素(Estrogen)。使用单向Anova统计检验进行数据分析,以检验各组之间的差异。结果:MSG剂量0.03mg/gBB和0.7mg/gBB对FSH(p=0.011)和雌激素(p=0.008)有显著性差异。
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引用次数: 1
Urogynaecology Training in South East Asia (SEA) and Asia 东南亚(SEA)和亚洲泌尿妇科培训
Pub Date : 2019-05-23 DOI: 10.20473/MOG.V1I12019.1-4
N. Roy
South East Asia (SEA) is made up of 11 countries (Viet-nam, Laos, Cambodia, Thailand, Myanmar, Malaysia, Singapore, Brunei, Philippines, Indonesia and Timor Leste) from Myanmar in the northwest to Timor Leste in the far south east. It is one of the most far flung region in Asia, with a land mass of 4.5 million km2 and theitspopulation of 641 million makes it the third most populous geographical region in the world after South Asia and East Asia. Asia is the world’s largest most populous continent stretching from the Middle East in the west to Japan in the east with a population of 4.567 billion.
东南亚(SEA)由11个国家(越南、老挝、柬埔寨、泰国、缅甸、马来西亚、新加坡、文莱、菲律宾、印度尼西亚和东帝汶)组成,从西北的缅甸到东南的东帝汶。它是亚洲最遥远的地区之一,拥有450万平方公里的土地面积和6.41亿人口,使其成为继南亚和东亚之后世界上人口第三多的地理区域。亚洲是世界上人口最多的大陆,西起中东,东至日本,人口达45.67亿。
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引用次数: 3
The effect of sitting and soaking therapy with binahong leaf (Anredera cordifolia) decoction on perineal wound healing 滨拿红叶汤坐泡疗法对会阴创面愈合的影响
Pub Date : 2019-05-23 DOI: 10.20473/MOG.V1I12019.28-33
Daini Zulmi, L. Septiani, Suryani Soepardan
Objective: To analyze the effect of sitting and soaking therapy with the decoction of Anredera cordifolia on the perineal wound healing in postpartum period mothers.Materials and Methods: The research method used is the Quasi-Experiment with pretest-posttest control group design, a sample of 62 primiparous postpartum period mothers with 2nd-grade perineal rupture. The sampling technique used is purposive sampling to obtain 31 respondents treated by 31 respondents. The wound healing variable was observed using the REEDA scale. The characteristic analysis is tested using Mann-Whitney statistical test, while to test the effect analysis is tested using the Wilcoxon test.Results: The results of this study in the intervention group showed 52.71% was cured after getting treatment for perineal wounds sitting and soaking therapy with the decoction of Anredera cordifolia. On the other hand, in the control group, using only clean water shows 27.90% recovered. Analysis data effect of using the decoction of Anredera cordifolia 25% containing on perineal wound healing showed results with Wilcoxon Test with value (p<0.05).Conclusion: Based on this result there is an effect of sitting and soaking therapy with the decoction of Anredera cordifolia on perineal wound healing for postpartum mothers.
目的:分析坐浸疗法配合堇黄汤对产后母亲会阴创面愈合的影响。材料与方法:研究方法为准实验,采用前测后测对照组设计,选取62例初产妇产后会阴破裂2级。采用的抽样技术是有目的抽样,由31名被调查者处理得到31名被调查者。采用REEDA量表观察伤口愈合变量。特征分析采用Mann-Whitney统计检验,效应分析采用Wilcoxon检验。结果:干预组会阴创面经堇柳汤坐泡治疗后治愈率为52.71%。另一方面,在对照组中,只使用干净的水,回收率为27.90%。分析数据:使用含25%的堇莲子煎剂对会阴创面愈合的影响,结果符合Wilcoxon检验(p<0.05)。结论:在此基础上,莲子汤坐泡疗法对产后母亲会阴创面愈合有一定的促进作用。
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引用次数: 2
期刊
Majalah Obstetri dan Ginekologi
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