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Chemical & Biomedical Imaging最新文献

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Chemical & Biomedical Imaging
Pub Date : 2025-06-23
Maria Niora, Martin Dufva, Liselotte Jauffred* and Kirstine Berg-Sørensen*, 
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引用次数: 0
Chemical & Biomedical Imaging
Pub Date : 2025-06-23
Bret A. Marckx, Hunter Maclennan and Ömer Özgür Capraz*, 
{"title":"","authors":"Bret A. Marckx, Hunter Maclennan and Ömer Özgür Capraz*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"3 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cbmi.5c00003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical & Biomedical Imaging
Pub Date : 2025-06-23
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引用次数: 0
MRI: A Dynamic Tool in Precision Medicine 核磁共振成像：精准医学的动态工具。
IF 5.7
Chemical & Biomedical Imaging
Pub Date : 2025-06-23 DOI: 10.1021/cbmi.5c00080
Zheng Huang,  and , Deju Ye*, 
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引用次数: 0
Chemical & Biomedical Imaging
Pub Date : 2025-06-23
Kun Wu, Zhicong Chao, Subi Aji, Yu Zhu, Hongxia Zhao, Ying An, Huangxian Ju and Ying Liu*, 
{"title":"","authors":"Kun Wu, Zhicong Chao, Subi Aji, Yu Zhu, Hongxia Zhao, Ying An, Huangxian Ju and Ying Liu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"3 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cbmi.4c00111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical & Biomedical Imaging
Pub Date : 2025-06-23
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引用次数: 0
Imaging of 4D Chemical Heterogeneity at the Electrochemical Interfaces. 电化学界面的四维化学非均质成像。
IF 5.7
Chemical & Biomedical Imaging
Pub Date : 2025-06-23 eCollection Date: 2025-09-22 DOI: 10.1021/cbmi.5c00077
Weitong Zhang, Qianjin Chen
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引用次数: 0
Chemical & Biomedical Imaging
Pub Date : 2025-06-23
Xinlan Zhou, Xinzhong Ruan, Xingjiang Li, Weiyuan Xu, Xinhui Xiao, Aiyi Chen, Yinghui Ding, Jilai Zhang, Gengshen Mo, Yong Jian, Xinyang Wu, Fangfu Ye, Zhiqiang Wang*, Yi Li* and Lixiong Dai*, 
{"title":"","authors":"Xinlan Zhou, Xinzhong Ruan, Xingjiang Li, Weiyuan Xu, Xinhui Xiao, Aiyi Chen, Yinghui Ding, Jilai Zhang, Gengshen Mo, Yong Jian, Xinyang Wu, Fangfu Ye, Zhiqiang Wang*, Yi Li* and Lixiong Dai*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"3 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cbmi.5c00012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical & Biomedical Imaging
Pub Date : 2025-06-23
Xiaolong Chen, Qianyi You, Yawen Guo, Jing Zhang, Qiao Hu, Chaowang Huang, Zhili Wu, Junjiang Deng, Jing Xu, Peng Zhao* and Mingdong Hu*, 
{"title":"","authors":"Xiaolong Chen, Qianyi You, Yawen Guo, Jing Zhang, Qiao Hu, Chaowang Huang, Zhili Wu, Junjiang Deng, Jing Xu, Peng Zhao* and Mingdong Hu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53181,"journal":{"name":"Chemical & Biomedical Imaging","volume":"3 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cbmi.4c00089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144429125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH-Responsive Liposomes for Targeted Detection of Pancreatic Adenocarcinoma Using MSOT. ph响应脂质体用于MSOT靶向检测胰腺腺癌。
IF 5.7
Chemical & Biomedical Imaging
Pub Date : 2025-06-23 eCollection Date: 2025-11-24 DOI: 10.1021/cbmi.5c00034
Happy Agarwal, Rohit Singh, Ryan C Bynum, Molly McNally, Jennifer Holter-Chakrabarty, Ajay Jain, William E Grizzle, Lacey R McNally

Pancreatic ductal adenocarcinoma (PDAC) diagnosis and treatment are limited due to the insufficient availability of contrast agents that can detect tumors with high sensitivity and specificity. Nanocontrast agents can be actively targeted toward the highly acidic tumor microenvironment to facilitate the detection of tumor cells during intraoperative imaging using an advanced imaging modality: multispectral optoacoustic tomography (MSOT). We developed IR780 dye encapsulated liposomes (Lipo-780) as a nanocontrast agent and actively targeted them using the pH low insertion peptide (pHLIP) V7 (V7-lipo-780) toward the extremely acidic pH tumor microenvironment of pancreatic cancer. Tumor-specific uptake of liposomes were evaluated in vitro in aggressive metastatic pancreatic cancer cells (S2VP10, S2013) and in vivo in orthotopic human pancreatic cancer xenograft murine model. Lipo-780 (110 nm, polydispersity index (PDI) of 0.13) were conjugated with V7 peptide using SMCC NH2-maleimide linker and the conjugation was confirmed with zeta potential measurements. The uptake of V7-lipo-780 increased by 3.5-fold in comparison to Lipo-780 in S2013 cells (p < 0.001), and by 2.4-fold (p < 0.001) at pH 6.6 in S2VP10 cells. Propidium iodide encapsulated liposomes (Lipo-PI) with a size of 118 nm validated the internalization of liposomes. In S2VP10 cells, V7-lipo-PI demonstrated higher uptake with the mean red fluorescence of 5535 counts in comparison to 334 counts for Lipo-PI at pH 6.6 (p < 0.001). Biodistribution analysis indicated 40× higher tumor accumulation of V7-lipo-780 in comparison to the liver (p < 0.001), and 4× higher tumor accumulation than the kidney (p < 0.001) post 6 h of intravenous administration. Histological analysis of kidney, liver, and spleen confirmed the nontoxic nature of liposomes. Tumor-specific liposome accumulation and IR780 contrast agent release prevent off-target toxicity with maximum contrast signal at the tumor site, further expanding the potential of MSOT for clinical applications.

胰导管腺癌（Pancreatic ductal adenocarcinoma， PDAC）的诊断和治疗受到限制，因为缺乏能够高灵敏度和特异性检测肿瘤的对比剂。纳米造影剂可以主动靶向高酸性肿瘤微环境，以便在术中成像时使用先进的成像方式：多光谱光声断层扫描（MSOT）来检测肿瘤细胞。我们开发了IR780染料包封脂质体（lipo780）作为纳米造影剂，并利用pH低插入肽（pHLIP） V7 （V7- lipo780）主动靶向pH极酸的胰腺癌肿瘤微环境。我们在侵袭性转移胰腺癌细胞（S2VP10, S2013）和原位人胰腺癌异种移植小鼠模型中评估了脂质体的肿瘤特异性摄取。将Lipo-780 （110 nm， PDI为0.13）通过SMCC nh2 -马来酰亚胺连接剂与V7肽偶联，并通过zeta电位测定对偶联效果进行了验证。与S2013细胞相比，v7 - lipo780的摄取增加了3.5倍（p < 0.001），在pH为6.6时，S2VP10细胞的v7 - lipo780的摄取增加了2.4倍（p < 0.001）。直径为118 nm的碘化丙啶包封脂质体（lipop - pi）证实了脂质体的内化。在S2VP10细胞中，pH为6.6时，v7 -脂质pi的平均红色荧光为5535次，而脂质pi的平均红色荧光为334次（p < 0.001）。生物分布分析显示，静脉给药6小时后，v7 -脂-780的肿瘤蓄积比肝脏高40倍（p < 0.001），比肾脏高4倍（p < 0.001）。肾、肝和脾的组织学分析证实了脂质体的无毒性质。肿瘤特异性脂质体积累和IR780造影剂释放防止脱靶毒性，在肿瘤部位获得最大的造影剂信号，进一步扩大了MSOT的临床应用潜力。
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引用次数: 0
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