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Gradient, Texture Driven Based Dynamic-Histogram Equalization For Medical Image Enhancement 基于梯度、纹理驱动的动态直方图均衡化医学图像增强
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-22 DOI: 10.46300/91011.2021.15.36
H. N. Vidyasaraswathi, M. C. Hanumantharaju
In many clinical diagnostic measurements, medical images play some significant role but often suffer from various types of noise and low-luminance, which causes some notable changes in overall system accuracy with misdiagnosis rate. To improve the visual appearance of object regions in medical images, image enhancement techniques are used as potential pre-processing techniques. Due to its simplicity and easiness of implementation, histogram equalization is widely preferred in many applications. But due to its mapping function based image transformation during enhancement process affect the biomedical patterns which are essential for diagnosis. To mitigate these issues in medical images, a new method based on gradient computations and Texture Driven based Dynamic histogram equalization (GTDDHE) is accomplished to increase the visual perception. The spatial texture pattern is also included to ensure the texture retention and associated control over its variations during histogram modifications. Experimental results on MRI, CT images, eyes images from medical image datasets and quantitative analysis by PSNR, structural similarity index measurement (SSIM), information entropy (IE) and validated that the proposed method offers improved quality with maximum retention of biomedical patterns across all types of medical images.
在许多临床诊断测量中,医学图像发挥着重要的作用,但往往存在各种类型的噪声和低亮度,导致系统整体准确率和误诊率发生了显著变化。为了改善医学图像中目标区域的视觉外观,图像增强技术被用作潜在的预处理技术。直方图均衡由于其简单易实现,在许多应用中被广泛采用。但由于其基于映射函数的图像变换在增强过程中会影响对诊断至关重要的生物医学模式。为了缓解医学图像中的这些问题,提出了一种基于梯度计算和纹理驱动的动态直方图均衡化(GTDDHE)的新方法来提高视觉感知。空间纹理模式也包括在直方图修改过程中,以确保纹理保留和对其变化的相关控制。对医学图像数据集中的MRI、CT图像、眼睛图像进行实验,并通过PSNR、结构相似指数测量(SSIM)、信息熵(IE)进行定量分析,验证了该方法在所有类型的医学图像中提供了更高的质量,最大限度地保留了生物医学模式。
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引用次数: 0
Evaluation of Performance Metrics of Thyroid Segmentation by Deep Learning Technique 利用深度学习技术评估甲状腺分割的性能指标
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-22 DOI: 10.46300/91011.2021.15.35
Nayana R. Shenoy, A. Jatti
Thyroid cancer is one of the commonly seen endocrine system cancer. Thyroid nodules appear as solid or fluid-filled masses on the thyroid. In many cases the thyroid nodules do not show any symptoms and due to this it leads to the critical situation up to death.All nodules are not cancerous and so it is very important to discriminate benign from malignant nodules. For diagnosing thyroid nodule the preferred imaging modality isUltrasound imaging.Due to inhomogeneous structure segmenting thyroid gland is a great challenge.Most of the researchers have implemented semi-automatic and automatic techniques to segment the nodules. In this paper we suggest a model to segment the region of interest by modifyingthe basic U-Netmodel. The performance metrics such as true positive, accuracy, F1-measure and dice coefficient is calculated and compared with basic model.
甲状腺癌症是常见的内分泌系统癌症之一。甲状腺结节表现为甲状腺上充满固体或液体的肿块。在许多情况下,甲状腺结节没有表现出任何症状,因此会导致危重情况直至死亡。所有的结节都不是癌性的,因此区分良性和恶性结节是非常重要的。诊断甲状腺结节的首选成像方式是超声成像。由于结构不均匀,分割甲状腺是一个巨大的挑战。大多数研究人员都采用了半自动和自动技术来分割结节。在本文中,我们提出了一个通过修改基本U-Net模型来分割感兴趣区域的模型。计算了真阳性、准确度、F1测度和骰子系数等性能指标,并与基本模型进行了比较。
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引用次数: 1
Information Sources, Knowledge and Practice Towards HIV/ Hepatitis B Co-Infection In Lagos, Nigeria 尼日利亚拉各斯艾滋病毒/乙型肝炎合并感染的信息来源、知识和实践
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-20 DOI: 10.46300/91011.2021.15.34
E. Adesina, O. Omojola, D. Imhonopi, Babatunde Adeyeye, Charity A. Ben-Enukora, Scholastica Anake
Attaining the objective of healthy lives and wellbeing Sustainable Development Goal 3 is hinged on effective health communication. This study investigates the information source usage, knowledge, attitude and practices of 200 dwellers of Lagos, Nigeria towards HIV/HBV co-infection. In this cross-sectional study, the simple random sampling method was employed in selecting 200 participants in the most populated local government in Lagos state, Nigeria. Questionnaire instrument was created, to elicit responses on four major areas: uses of information sources, knowledge, attitude, health practice towards HIV/HBV co-infection. Descriptive statistical data in percentages and cross-tabulations were employed. The study indicated that 60.4% of the respondents source for information on HIV/HBV co-infection on television. Furthermore, while 60% noted the co-infection is caused by a virus 48.5% declared that the fear of death will be their main concern if they were diagnosed with the co-infection. The result further reveals that only 26.8% of the sampled respondents have been tested for the co-infection in Lagos State. The study concludes that there is need for the creation of preventive information campaigns for awareness in order to mitigate the rising cases of HIV/HBV co-infection as well as influence persons towards healthy practices. The insight from this study would further provide a focal point of direction to government as well as non-governmental organisations working on HIV/HBV co-infection in Nigeria.
实现健康生活和福祉的目标,可持续发展目标3取决于有效的卫生宣传。本研究调查了尼日利亚拉各斯200名居民对HIV/HBV合并感染的信息源使用情况、知识、态度和行为。在横断面研究中,采用简单随机抽样的方法,在尼日利亚拉各斯州人口最多的地方政府中选择200名参与者。制定了问卷调查工具,征求对四个主要领域的答复:信息来源的使用、知识、态度、对艾滋病毒/乙型肝炎病毒合并感染的保健做法。采用百分比和交叉表的描述性统计数据。研究表明,60.4%的受访者通过电视获取艾滋病毒/乙型肝炎病毒合并感染的信息。此外,虽然60%的人指出合并感染是由一种病毒引起的,但48.5%的人表示,如果被诊断为合并感染,他们主要担心的是害怕死亡。结果进一步显示,在拉各斯州,只有26.8%的抽样调查对象接受了合并感染检测。该研究的结论是,有必要开展提高认识的预防性宣传运动,以减少艾滋病毒/乙型肝炎病毒合并感染病例的增加,并影响人们采取健康的做法。这项研究的见解将进一步为尼日利亚致力于艾滋病毒/乙型肝炎病毒合并感染的政府和非政府组织提供一个重点方向。
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引用次数: 1
Importance of Some Specifications of Heterogeneous Architectures (CPU+GPU) for 3D Cone-Beam-CT Image Reconstruction Using OpenCL 异构体系结构(CPU+GPU)的一些规范对OpenCL三维锥束CT图像重建的重要性
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-20 DOI: 10.46300/91011.2021.15.33
T. Nouioua, A. H. Belbachir
Medical imaging has found an important way for routine daily practice using cone-beam computed tomography to reconstruct a 3D volume image using the Feldkamp-Davis-Kress (FDK) algorithm. This way can minimize the patient’s time exposure to X-rays. However, its implementation is very costly in computation time, which constitutes a handicap problem in practice. For this reason, the use of acceleration methods on GPU becomes a real solution. For the acceleration of the FDK algorithm, we have used the GPU on heterogeneous platforms. To take full advantage of the GPU, we have chosen useful features of the GPUs and, we have launched the acceleration of the reconstruction according to some technical criteria, namely the work-groups and the work-items. We have found that the number of parallel cores, as well as the memory bandwidth, have no effect on runtimes speedup without being rough in the choice of the number of work-items, which represents a real challenge to master in order to be able to divide them efficiently into work-groups according to the device specifications considered as principal difficulties if we do not study technically the GPU as a hardware device. After an optimized implementation using kernels launched optimally on GPU, we have deduced that the high capacities of the devices must be chosen with a rough optimization of the work-items which are divided into several work-groups according to the hardware limitations.
医学成像已经找到了一种重要的方法,用于常规的日常实践,使用锥束计算机断层扫描重建三维体图像,使用Feldkamp-Davis-Kress (FDK)算法。这种方法可以减少病人暴露在x射线下的时间。然而,它的实现在计算时间上非常昂贵,这在实践中构成了一个障碍问题。因此,在GPU上使用加速方法成为一个真正的解决方案。为了加速FDK算法,我们在异构平台上使用了GPU。为了充分发挥GPU的优势,我们选择了GPU的有用特性,并根据一些技术标准(即工作组和工作项)启动了重构的加速。我们发现并行核的数量以及内存带宽对运行时加速没有影响,而不会在工作项数量的选择中产生粗略的影响,这代表了一个真正的挑战,以便能够根据被认为是主要困难的设备规格将它们有效地划分为工作组,如果我们不从技术上研究GPU作为硬件设备。在使用GPU上最优启动的内核进行优化实现后,我们推断出设备的高容量必须通过对工作项的粗略优化来选择,这些工作项根据硬件限制分为几个工作组。
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引用次数: 0
AtDREB2A Gene Expression Under Control of the Inducible Promoter and Virus 5’-untranslated Regions Improves Tolerance to Salinity in Nicotiana Tabacum 诱导启动子和病毒5′-非翻译区调控AtDREB2A基因表达提高烟草耐盐性
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-19 DOI: 10.46300/91011.2021.15.32
O. Karpova, A. Alexandrova, R. Nargilova, M. Ramazanova, R. Kryldakov, B. Iskakov
Transcriptional factor DEHYDRATION-RESPONSIVE ELEMENT BINDING PROTEIN 2A (DREB2A) induces the expression of many genes in dehydration, heat shock, and salinity in Arabidopsis. Deletion of sequence coding the 30 amino acid central region transforms full length (FL) protein DREB2A FL into a more stable and constitutively active form known as DREB2A CA. Here, using agrobacteria, a leaf disc transformation of Nicotiana tabacum v. Samsun NN was carried out by transgenes AtDREB2A-FL and AtDREB2A-CA coding the proteins with His-tag on the С-end. The effects of combinations of constitutive 35S CaMV promoter or inducible rd29A promoter with different viral or artificial 5’-untranslated regions (UTR), 5’TMV, 5’PVY, 5’AMV or 5’ARC1, known as translational enhancers were evaluated on the both transgenes’ expression. Using an antibody to His-tag, recombinant protein synthesis was detected in transgenic plants in normal and heat shock conditions. After comparative analysis, it was shown that the properties of different 5’-UTRs vary greatly and depended on separate conjunction of promoter and transgene. The integration of AtDREB2A CA under control of the rd29A promoter and 5’TMV or 5’AMV in genome effectively improved tolerance of tobacco transgenic plants to 400 mM NaCl and to drought.
转录因子脱水反应元件结合蛋白2A(DREB2A)在拟南芥的脱水、热休克和盐度中诱导许多基因的表达。缺失编码30个氨基酸的中心区的序列将全长(FL)蛋白DREB2A FL转化为一种更稳定和组成型活性的形式,称为DREB2A CA。在这里,使用农杆菌,通过编码С端带有His标签的蛋白质的转基因AtDREB2A FL-AtDREB2A CA对Nicotiana tabacum v.Samsun NN进行叶盘转化。评估了组成型35S-CaMV启动子或诱导型rd29A启动子与不同的病毒或人工5’-非翻译区(UTR)、5’TMV、5’PVY、5’AMV或5’ARC1(称为翻译增强子)的组合对两种转基因表达的影响。使用His标签的抗体,在正常和热休克条件下在转基因植物中检测到重组蛋白的合成。经过比较分析,不同5’-UTR的性质差异很大,并且依赖于启动子和转基因的单独连接。在rd29A启动子和基因组中的5’TMV或5’AMV的控制下整合AtDREB2A CA有效地提高了烟草转基因植物对400mM NaCl和干旱的耐受性。
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引用次数: 0
Geographic Classification and Identification of SARS-CoV2 From Related Viral Sequences 从相关病毒序列中对严重急性呼吸系统综合征冠状病毒2型的地理分类和鉴定
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-19 DOI: 10.46300/91011.2021.15.31
F. F. Sherif, K. Ahmed
The COVID-19 pandemic has introduced to mild the risks of deadly epidemic-prone illnesses sweeping our globalized planet. The pandemic is still going strong, with additional viral variations popping up all the time. For the close to future, the international response will have to continue. The molecular tests for SARS-CoV-2 detection may lead to False-negative results due to their genetic similarity with other coronaviruses, as well as their ability to mutate and evolve. Furthermore, the clinical features caused by SARS-CoV-2 seem to be like the symptoms of other viral infections, making identification even harder. We constructed seven hidden Markov models for each coronavirus family (SARS-CoV2, HCoV-OC43, HCoV-229E, HCoV-NL63, HCoV-HKU1, MERS-CoV, and SARS-CoV), using their complete genome to accurate diagnose human infections. Besides, this study characterized and classified the SARS-CoV2 strains according to their different geographical regions. We built six SARS-CoV2 classifiers for each world's continent (Africa, Asia, Europe, North America, South America, and Australia). The dataset used was retrieved from the NCBI virus database. The classification accuracy of these models achieves 100% in differentiating any virus model among others in the Coronavirus family. However, the accuracy of the continent models showed a variable range of accuracies, sensitivity, and specificity due to heterogeneous evolutional paths among strains from 27 countries. South America model was the highest accurate model compared to the other geographical models. This finding has vital implications for the management of COVID-19 and the improvement of vaccines.
新冠肺炎大流行降低了席卷全球的致命流行病的风险。新冠疫情仍在持续,不断出现额外的病毒变异。在不久的将来,国际社会必须继续作出反应。严重急性呼吸系统综合征冠状病毒2型检测的分子测试可能会导致假阴性结果,因为它们与其他冠状病毒的基因相似,并且具有变异和进化的能力。此外,严重急性呼吸系统综合征冠状病毒2型引起的临床特征似乎与其他病毒感染的症状相似,这使得识别更加困难。我们为每个冠状病毒家族(严重急性呼吸系统综合征冠状病毒2型、冠状病毒OC43型、冠状病毒229E型、冠状病毒NL63型、冠状病毒HKU1型、MERS-CoV型和非典型肺炎冠状病毒)构建了七个隐马尔可夫模型,使用它们的全基因组准确诊断人类感染。此外,本研究还根据不同的地理区域对严重急性呼吸系统综合征冠状病毒2型菌株进行了表征和分类。我们为每个世界大陆(非洲、亚洲、欧洲、北美、南美和澳大利亚)建立了六个严重急性呼吸系统综合征冠状病毒2型分类器。使用的数据集是从NCBI病毒数据库中检索的。这些模型的分类准确率在区分冠状病毒家族中的任何病毒模型时达到100%。然而,由于来自27个国家的菌株之间的异质进化路径,大陆模型的准确性显示出不同的准确性、敏感性和特异性。与其他地理模型相比,南美洲模型是准确度最高的模型。这一发现对新冠肺炎的管理和疫苗的改进具有重要意义。
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引用次数: 1
The State of the Cardiovascular System Under the Action of Industrial Electromagnetic Fields 工业电磁场作用下心血管系统的状态
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-15 DOI: 10.46300/91011.2021.15.30
G. Gazya, V. Eskov, M. Filatov
The influence of industrial low-frequency electromagnetic fields on the human body is currently insufficiently studied. However, such fields are quite common in modern automated production, where various electric drives are used, and they significantly affect the quality of human life. This is especially evident in the conditions of the North, where special ecological factors cause significant changes in the systems of regulation of the body's functions. This study examines the influence of such fields on the parameters of the cardiovascular system of female workers in the oil and gas industry in Russia. Four groups of women were studied, differing in age and electromagnetic field exposure. As a result, the effects of influence of the fields were revealed, especially for the older age group.
工业低频电磁场对人体的影响目前研究不足。然而,在现代自动化生产中,这些领域非常常见,在现代生产中使用了各种电动驱动器,它们极大地影响了人类的生活质量。这在北方的条件下尤其明显,那里的特殊生态因素导致身体功能调节系统发生重大变化。本研究考察了这些领域对俄罗斯石油和天然气行业女性工人心血管系统参数的影响。研究了四组不同年龄和电磁场暴露的女性。结果,磁场的影响显现出来,尤其是对老年人。
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引用次数: 6
Effect of Dynamic Stereoscopic Vision on Balance with Induced Anisometropia 动态立体视觉对诱发性屈光参差平衡的影响
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-14 DOI: 10.46300/91011.2021.15.27
Taeho Jun, Joong-Hwi Kim
The purpose of this study was to investigate the correlation between dynamic stereoscopic vision and balance, and to compare our results to previous studies that sought to determine the correlation between changes in visual information and balance. Thirty-three healthy adults participated in the measurement of balance by inducing anisometropia with +0.0D, +2.0D, and +5.0D refractive lenses placed in specially made glasses that removed peripheral vision. COP data was collected via force plate and was evaluated by converting it to COP velocity. An α <0.05 was considered statistically significant. Our results show that, provided it is above a minimum threshold level, the greater the change in dynamic stereoscopic vision, the poorer the balance. And it was found that changes below a minimum threshold level did not affect the balance. These results provide a potential explanation for the complementary compensatory action of sensory information, which could not be explained previously based on the change of balance due to changes in visual information across both eyes. Given these data, it seems clear that vision correction is essential for those affected by dynamic stereoscopic vision formation disorders above a certain level in order to improve balance. On the other hand, dynamic stereoscopic vision formation disorders below a certain level can likely be improved using simple somatosensory treatments. This study will help physical therapists better consider dynamic stereoscopic vision when evaluating and conducting therapies designed to increase balance.
本研究的目的是探讨动态立体视觉与平衡之间的关系,并将我们的研究结果与之前试图确定视觉信息变化与平衡之间关系的研究进行比较。33名健康成人通过将+0.0D、+2.0D和+5.0D屈光透镜置入特制的去外周视觉的眼镜内诱发参差来测量平衡。通过测力板收集COP数据,并将其转换为COP速度进行评估。α <0.05为差异有统计学意义。我们的研究结果表明,在超过最小阈值水平的情况下,动态立体视觉变化越大,平衡性越差。研究发现,低于最低阈值水平的变化不会影响平衡。这些结果为感官信息的互补补偿作用提供了一种潜在的解释,这种作用以前不能基于双眼视觉信息变化引起的平衡变化来解释。鉴于这些数据,似乎很清楚,视力矫正对于那些受一定程度以上的动态立体视觉形成障碍影响的人来说是必不可少的,以改善平衡。另一方面,低于一定水平的动态立体视觉形成障碍可能通过简单的体感治疗得到改善。这项研究将帮助物理治疗师在评估和实施旨在增加平衡的治疗时更好地考虑动态立体视觉。
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引用次数: 0
Biochemical Blood Parameters and Mineral Metabolism in the Adaptive Period in the Bovine Cattle in the Conditions of the Voronezh Region 沃罗涅日地区条件下牛适应期血液生化参数和矿物质代谢
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-14 DOI: 10.46300/91011.2021.15.29
A. Vostroilov, I. Ventsova, V. Safonov
The study of the process of adaptation of the Belgian breed bovine cattle to the conditions of the Voronezh Region was based on the biochemical blood parameters and mineral metabolism. The experiment included 20 animals divided into four groups (five heads in each group): Group I – covering age heifers, Group II – heifers, Group III – first-calf cows a month after calving, Group IV – one-month-old heifers. In some groups, adaptation processes resulted in deviations from the reference values. In Group II, the level of BUN was 4.7% higher than the norm. In Groups I and IV, the levels of glucose were higher by 7.6% and 38.5%, respectively. In Groups II and III, ALT levels were higher than the norm by 9.1%; in Group I – by 15.7%. In Group II, the level of AST was higher by 5.8% in comparison with the norm. The analysis of mineral metabolism showed that the content of iron was lower than the reference values in first-calf cows in Group III and in heifers in Group IV by 14.4 and 10.8%, respectively. In Group II, the content of copper met the upper border of the reference values. In Group IV, it was elevated by 18.2% in comparison with the norm. The specified deviations indicated the intensification of the metabolic processes during the adaptation of animals to new conditions. The study results showed that the animals of the Belgian breed were capable of adaptation, which provided successful adaptation to new conditions of the Voronezh Region (Russia).
根据血液生化参数和矿物质代谢,研究了比利时品种牛对沃罗涅日地区条件的适应过程。实验包括20只动物,分为四组(每组5头):第一组——覆盖年龄的小母牛,第二组——小母牛,第一组——产仔后一个月的第一头小牛,第四组——一个月大的小母牛。在一些群体中,适应过程导致偏离参考值。在第二组中,BUN水平比正常值高4.7%。在第I组和第IV组中,葡萄糖水平分别升高7.6%和38.5%。在第二组和第三组中,ALT水平比正常值高9.1%;在第I组中,AST水平比正常人高出5.8%。矿物代谢分析显示,第III组第一头小牛和第IV组小母牛的铁含量分别比参考值低14.4%和10.8%。在第二组中,铜含量符合参考值的上限。在第四组中,与正常人相比,它提高了18.2%。特定的偏差表明,在动物适应新条件的过程中,代谢过程加剧。研究结果表明,比利时品种的动物具有适应能力,成功地适应了俄罗斯沃罗涅日地区的新条件。
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引用次数: 1
The Effects of PNF Pattern Training on the Walking Ability of Total Knee Replacement Patients PNF模式训练对全膝关节置换术患者行走能力的影响
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-07-13 DOI: 10.37394/23203.2021.16.33
Jin Park
The purpose of this study was to verify the effectiveness of proprioceptive neuromuscular facilitation pattern to improve walking ability of total knee replacement patients. In this study, 10 patients with total knee replacement were recruited from rehabilitation hospital. They were divided into two groups: a PNF group (n=5) and a control group (n=5). The PNF group received 30 minutes of continuous passive motion (CPM) and PNF training for 15 minutes five times a week for two weeks. The control group received 30 minutes of CPM and strengthening exercise for 15minutes five times a week for two weeks. Spatiotemporal parameters were measured by Biodex gait trainer 2. After the training periods, the PNF group showed a significant improvement in walking speed and step length on the non-operated side, time on each foot on the operated side (p<0.05). The results of this study showed that PNF pattern training was more effective at improving walking ability. Therefore, improve the walking ability of total knee replacement patients, PNF lower pattern should be considered.
本研究的目的是验证本体感觉神经肌肉促进模式对全膝关节置换术患者行走能力的改善效果。本研究从康复医院招募10例全膝关节置换术患者。将患者分为两组:PNF组(n=5)和对照组(n=5)。PNF组接受连续被动运动(CPM) 30分钟,PNF训练15分钟,每周5次,持续2周。对照组接受30分钟的CPM和15分钟的强化运动,每周5次,持续两周。采用Biodex步态训练器2进行时空参数测量。训练结束后,PNF组在非手术侧行走速度、步长、手术侧每只脚行走时间上均有显著改善(p<0.05)。本研究结果表明,PNF模式训练在提高行走能力方面更有效。因此,提高全膝关节置换术患者的行走能力,应考虑PNF低模式。
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引用次数: 0
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International Journal of Biology and Biomedical Engineering
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