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Changes in Red Blood Cell Membrane Properties: The Role of Metabolic Syndrome Components 红细胞膜性质的变化:代谢综合征成分的作用
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-06-21 DOI: 10.46300/91011.2021.15.26
Yuliya Birulina, I. Petrova, V. V. Ivanov, E. Buyko, R. R. Shaibekova, A. Grigoreva, I. Kovalev, A. Nosarev, S. Gusakova
Metabolic syndrome (MetS) is a cluster of metabolic, hormonal and hemodynamic disorders that contribute to a change in the structural and functional status of erythrocytes and contribute to dysregulation of their cation transport function, where Ca2+ -dependent potassium channels (KCa channels) play an important role. A MetS model was performed using male Wistar rats, which were divided into control and experimental groups. Rats in the control group were fed standard rat chow. Rats in the experimental group were exposed to a high-fat and high-carbohydrate (HFHC) diet for 12 weeks. The data obtained indicate that the HFHC diet led to obesity, high blood pressure, hyperglycemia, impaired glucose tolerance, and dyslipidemia. The level of glutathione (GSH) decreased in the erythrocytes of rats suffering from MetS, but the level of malondialdehyde (MDA) increased. It was shown that the amplitude of the membrane potential of erythrocytes of rats with MetS changed depending on the acting agent: when stimulated with calcium ionophore A23187 it decreased, when the redox system ascorbat –phenazine methosulfate was used, it increased compared to the control group. The data obtained indicate that a HFHC diet leads to changes in the physical and chemical properties of the erythrocyte membrane.
代谢综合征(MetS)是一组代谢、激素和血液动力学疾病,导致红细胞结构和功能状态的改变,并导致其阳离子运输功能失调,其中Ca2+依赖性钾通道(KCa通道)起重要作用。采用雄性Wistar大鼠建立MetS模型,分为对照组和实验组。对照组大鼠饲喂标准鼠粮。实验组大鼠喂食高脂高碳水化合物(HFHC) 12周。所获得的数据表明HFHC饮食导致肥胖、高血压、高血糖、糖耐量受损和血脂异常。MetS大鼠红细胞中谷胱甘肽(GSH)水平降低,丙二醛(MDA)水平升高。结果表明,met大鼠红细胞膜电位的幅值随作用剂的不同而变化:用钙离子载体A23187刺激时,其幅值降低;用抗坏血酸-苯那嗪甲硫代硫酸盐氧化还原系统时,其幅值较对照组增加。所获得的数据表明,HFHC饮食导致红细胞膜的物理和化学性质的变化。
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引用次数: 0
Distribution of Polymorphic Marker of Genes of the Renin-angiotensin System RAS (AGT, AGTR1, АСЕ), ITGB3, PPARG) in Pa-tients With Essential Arterial Hypertension Depending on the Nature of the Nocturnal De-crease of BP 肾素-血管紧张素系统RAS (AGT, AGTR1, АСЕ), ITGB3, PPARG)基因多态性标记在原发性高血压患者夜间血压降低性质中的分布
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-06-03 DOI: 10.46300/91011.2021.15.24
T. Zotova, M. Azova, A. A. Lukanina, A. Aissa, M. Blagonravov
A clinical-genetic study using ABPM (24-hour BP monitoring) and Holter’s ECG methods in 49 pa-tients with essential arterial hypertension (group 1: 17 patients without sufficient nocturnal BP de-crease СI≤10%, and group 2: 32 patients with suf-ficient nocturnal BP decrease СI≥10%,) was per-formed for comparative analysis of the genotype frequencies of ACE, AGT, AGTR1, ITGB3, and PPARG. The study was conducted in order to clari-fy the pathogenetic mechanisms of the implementa-tion of different dynamics of nocturnal blood pres-sure in patients with hypertension without metabol-ic syndrome. It was found that in group 1, protec-tive genotype II of the ACE gene was more com-mon (p ≤ 0.025) than in the population data. A sig-nificant increase (p ≤ 0.025) in the frequency of the CC genotype of the AGTR1 gene responsible for the formation of insulin resistance compared to the population data was combined with a significant increase in the frequency of autonomic dysfunction in patients of group 1 - 83.4% vs. 64.5% group 2 respectively. The results obtained indicate the pos-sible pathogenetic links between genetically deter-mined insulin resistance and autonomic nervous system dysfunction and allows us to determine therapeutic approaches for correcting the noctur-nal blood pressure profile.
采用ABPM(24小时血压监测)和Holter’s ECG方法对49例原发性动脉高压患者(第1组:17例夜间血压下降不足СI≤10%,第2组:32例夜间血压降低不足СI≥10%)进行了临床遗传学研究,以比较分析ACE、AGT、AGTR1、ITGB3和PPARG的基因型频率。本研究旨在阐明在无代谢综合征的高血压患者中实施不同夜间血压动态的发病机制。结果发现,在第1组中,ACE基因的保护性基因型II比群体数据中更常见(p≤0.025)。与人群数据相比,导致胰岛素抵抗形成的AGTR1基因CC基因型频率显著增加(p≤0.025),同时第1组患者自主神经功能障碍频率显著增加,分别为83.4%和64.5%。所获得的结果表明,遗传决定的胰岛素抵抗和自主神经系统功能障碍之间可能存在致病联系,并使我们能够确定纠正夜间血压的治疗方法。
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引用次数: 0
The Impact of COVID-19 on Mental Health COVID-19对心理健康的影响
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-06-03 DOI: 10.46300/91011.2021.15.23
Donart Koci, Festina Morina, Fatlinda Hoxhaj, Antigona Ukëhaxhaj
Infection with the new coronavirus (severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The virus that causes COVID-19 spreads easily among humans and more continues to be detected over time as to how it spreads. The effect that this crisis will have on the mental health of the population, both in the short and long term, is unknown. In the acute phase, fears of possible exposure to infection, loss of employment, and financial strain are likely to increase psychological distress in the wider population. In the long run, grief and trauma are likely to appear as financial and social impacts become ingrained, the risk of depression and suicide may increase. Lack of hugs, handshakes, free movement and isolation have made it impossible for people to socialize and behave normally with each other. Anxiety, fear, insecurity and lack of self-confidence are some of the main problems that people faced during quarantine and that they may face after the release of the measures. The purpose of this paper is to prove how much the Pandemic and the situation with COVID-19 have affected the mental health of the population in the city of Prizren and Gjakova. Quantitative study method was used for the realization of this work. This paper is based on the data extracted from the questionnaire completed together with the citizens of the municipalities of Prizren and Gjakova. For the realization of this scientific research are involved 200 citizens. Age groups, gender, economic status, level of education and place of residence were analyzed. The study included people aged 20 to 50 years. The most included gender in the study is the female with 59% while the male gender with 41%. All results are presented in graphs worked with SPSS program.
感染新型冠状病毒(严重急性呼吸综合征冠状病毒2或SARS-CoV-2)会导致2019年冠状病毒病(COVID-19)。导致COVID-19的病毒很容易在人与人之间传播,随着时间的推移,人们会发现更多关于其传播方式的病毒。这场危机对人口心理健康的短期和长期影响尚不清楚。在急性阶段,对可能受到感染、失业和经济紧张的恐惧可能会增加更广泛人群的心理困扰。从长远来看,随着经济和社会影响变得根深蒂固,悲伤和创伤可能会出现,抑郁和自杀的风险可能会增加。缺乏拥抱、握手、自由活动和隔离,使得人们无法进行社交和正常行为。焦虑、恐惧、不安全感和缺乏自信是人们在隔离期间面临的一些主要问题,也是他们在措施发布后可能面临的问题。本文的目的是证明大流行和COVID-19的情况对普里兹仁和贾科娃市人口的心理健康有多大影响。本工作的实现采用了定量研究方法。本文基于与普里兹连市和贾科娃市的公民一起完成的问卷调查中提取的数据。为实现这一目标,有200名市民参与了科学研究。分析了年龄、性别、经济状况、教育程度和居住地。该研究包括20至50岁的人。研究中涉及最多的性别是女性,占59%,而男性占41%。所有结果均以图形形式呈现,并使用SPSS程序进行处理。
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引用次数: 4
An Artificial Intelligence Approach Based on Hybrid CNN-XGB Model to Achieve High Prediction Accuracy through Feature Extraction, Classification and Regression for Enhancing Drug Discovery in Biomedicine 一种基于混合CNN-XGB模型的人工智能方法,通过特征提取、分类和回归实现高预测精度,增强生物医学中的药物发现
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-06-02 DOI: 10.46300/91011.2021.15.22
Mukesh Madanan, B. Sayed, Nurul Akhmal Mohd Zulkefli, Nitha C. Velayudhan
In the field of biomedicine, drug discovery is the cycle by which new and upcoming medicines are tested and invented to cure ailments. Drug discovery and improvement is an extensive, complex, and exorbitant cycle, settled in with a serious extent of vulnerability that a drug will really be successful or not. Developing new drugs have several challenges to enrich the current field of biomedicine. Among these ultimatums, predicting the reaction of the cell line to the injected or consumed drug is a significant point and this can minimize the cost of drug discovery in sophisticated fashion with a stress on the minimum computational time. Herein, the paper proposes a deep neural network structure as the Convolutional Neural Network (CNN) to detain the gene expression features of the cell line and then use the resulting abstract features as the input data of the XGBoost for drug response prediction. Dataset constituting previously identified molecular features of cancers associated to anti-cancer drugs are used for comparison with existing methods and proposed Hybrid CNNXGB model. The results evidently depicted that the predicted model can attain considerable enhanced performance in the prediction accuracy of drug efficiency.
在生物医学领域,药物发现是测试和发明治疗疾病的新药物和即将问世的药物的周期。药物的发现和改进是一个广泛的、复杂的、过高的循环,在很大程度上存在着药物是否真正成功的脆弱性。开发新药是当前生物医学领域的一大挑战。在这些最后通牒中,预测细胞系对注射或消耗的药物的反应是一个重要的点,这可以最大限度地减少药物发现的成本,以复杂的方式,以最小的计算时间为重点。本文提出一种深度神经网络结构卷积神经网络(Convolutional neural network, CNN),保留细胞系的基因表达特征,然后将得到的抽象特征作为XGBoost的输入数据进行药物反应预测。使用先前确定的抗癌药物相关癌症分子特征数据集与现有方法和提出的Hybrid CNNXGB模型进行比较。结果表明,该预测模型在药物效率预测精度上有较大幅度的提高。
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引用次数: 2
Application of Organic and Inorganic Fertilizers Affects the Growth and Biomass Semanggi (Marsilea crenata Presl.) 有机肥和无机肥的施用对三芒吉(Marsilea crenata Presl.)生长和生物量的影响
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-05-17 DOI: 10.46300/91011.2021.15.19
Mustika Tripatmasari, A. Ariffin, E. Nihayati, M. Agil
Semanggi (Marsilea crenata Presl.) is one of the aquatic plants that have been widely used by the community as food and medicinal raw materials. One of the important factors in cultivating clover is optimal fertilizer management. The incorporation of organic and inorganic nutrients has an effect on soil fertility has been repeatedly demonstrated in several studies, but there are not specific guidelines on clover cultivation. The challenge now is to combine organic matter of different qualities with inorganic fertilizers to optimize nutrient availability for the clover plant. The results of research on clover cultivation have also not been widely carried out. Therefore, it is very important to do this research with the aim of knowing the optimal effect of organic (cow manure) and inorganic (nitrogen, potassium) fertilizers on the growth and yield of clover (Marsilea crenata Presl.). The research was conducted at the Screen House of the Faculty of Agriculture, Brawijaya University. The study was designed using a non-factorial randomized block design (RBD) with 8 (eight) treatment combinations of soil types and fertilization [inorganic (N, K) cow manure organic fertilizer (CM)], namely: P0 = soil, without fertilizer; P1 = soil, 138 kg N ha-1; P2 = soil, 136 kg K ha-1; P3 = soil, N and K, 138 and 136 kg ha-1; P4 = soil, 20x103kg of cow manure ha-1; P5 = soil, 20x103 kg of cow manure ha-1, 138 kg N ha-1; P6 = soil, 20x103 kg of cow manure ha-1, 136 kg K ha-1; P7 = soil, 20x103 kg of cow manure ha-1, N and K, 138 and 136 kg ha-1 with 3 replications, so that 24 experimental units were obtained. Each experimental unit consisted of 5 plants. Growth observations were observed destructively at the ages of 4, 8, 12, 16, 20, 24, 28, 32 days after planting (DAP). The results showed that there was an increase in the growth and yield of biomass in the soil combination, 20x103 kg of cow manure ha-1 (P4) was compared with the treatment without the addition of organic fertilizers (cow manure) on plant growth and yield parameters, such as stolon length (74.78 cm), number of leaves (160.44), leaf area (1379.28 cm2), root length (23.85 cm), stomata density and number of stomata (13.25); Stomata width (10.87 cm); Stomata length (19.76 cm), leaf fresh weight (12,907 g), leaf dry weight (1,802 g), total fresh weight 210,830 g, total dry weight 7,823 g, leaf harvest fresh weight (64.19 g); stalk (130.54 g); root (79.75 g); total 274.48 g), harvest dry weight of leaves (11.36 g); stalk (24.88 g); root (9.55 g); a total of 45.78 g) and the chlorophyll a content (0.804 mg.g-1); chlorophyll b (1.121mg.g-1); and total chlorophyll (1.924 mg.g-1).
山葵(Marsilea crenata Presl.)是一种被广泛用作食品和药用原料的水生植物。三叶草栽培的重要因素之一是肥料管理的优化。有机和无机养分的结合对土壤肥力的影响已在几项研究中反复得到证实,但三叶草种植尚无具体的指导方针。现在的挑战是将不同质量的有机物质与无机肥料结合起来,以优化三叶草植物的养分利用率。关于三叶草栽培的研究结果也没有得到广泛的应用。因此,研究有机肥(牛粪)和无机肥(氮、钾)对三叶草生长和产量的最优影响具有重要意义。这项研究是在布拉维贾亚大学农业学院的屏幕屋进行的。本研究采用非因子随机区组设计(RBD),采用8种土壤类型和施肥[无机(N, K)牛粪有机肥(CM)]处理组合,即:P0 =土壤,不施肥;P1 =土壤,138 kg N ha-1;P2 =土壤,136 kg kha -1;P3 =土壤,N和K, 138和136 kg ha-1;P4 =土壤,20 × 103kg牛粪ha-1;P5 =土壤,20 × 103 kg牛粪hm -1, 138 kg N hm -1;P6 =土壤,20 × 103 kg牛粪hm -1, 136 kg K hm -1;P7 =土壤,20 × 103 kg牛粪ha-1, N和K, 138和136 kg ha-1, 3个重复,共24个试验单元。每个实验单元由5株植物组成。在种植后4、8、12、16、20、24、28、32天(DAP)进行破坏性生长观察。结果表明:土壤组合中生物量的生长和产量均有提高,与未添加有机肥(牛粪)处理相比,施用20 × 103 kg牛粪ha-1 (P4)对匍匐茎长(74.78 cm)、叶片数(160.44)、叶面积(1379.28 cm2)、根长(23.85 cm)、气孔密度和气孔数(13.25)等植物生长和产量参数有显著影响;气孔宽度(10.87 cm);气孔长度(19.76 cm),叶鲜重(12,907 g),叶干重(1,802 g),总鲜重210,830 g,总干重7,823 g,收获叶鲜重(64.19 g);茎(130.54 g);根(79.75 g);总274.48克),收获叶片干重(11.36克);茎(24.88 g);根(9.55 g);共45.78 g),叶绿素A含量为0.804 mg.g-1;叶绿素b (1.121mg.g-1);总叶绿素(1.924 mg.g-1)。
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引用次数: 1
Characteristic of Microphyta Distribution of Pager River, Central Kalimantan 加里曼丹中部佩格尔河小生植物分布特征
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-05-17 DOI: 10.46300/91011.2021.15.20
Inga Torang, S. Gumiri, Ardianoor Ardianoor, A. Jaya
Environmental damage due to natural resource extraction, especially in watershed areas, seems to be of increasing concern and so far, from the aspect of aquatic and water resources, plankton is commonly used as an indicator of environmental damage. This study explores the distribution of microphyta as a parameter of environmental damage. The research was conducted in Pager watershed, Central Kalimantan and sampled at 2 (two) stations, namely station A (for the right side of the river) and station B (for the left side of the river). The study was conducted 13 sampling times, which began in the period 25 May 2019 ending until 9 November 2019. Laboratory analysis to identify the type and number of microphyta was carried out at the Palangka Raya University Laboratory. The results showed that the number of microphyta taxa at station A (right side of the river) was 12-13 species, more than station B (left side of the river). The number of microphyta taxa at Station B is 8 - 9 species, it is suspected that there is an influence from the gray water settlements around the left side, especially when the water level drops. The distribution characteristics of microphyta in the Pager river are as follows: large number of taxa/species, low abundance and low diversity index. River/peat water environments are vulnerable to change, especially human interference. This research shows the potential use of microphyta as an indicator of environmental damage.
自然资源开采造成的环境损害,特别是在流域地区,似乎越来越令人关切,迄今为止,从水生和水资源方面来看,浮游生物通常被用作环境损害的指标。本研究探讨了作为环境破坏参数的微云的分布。该研究在加里曼丹中部的佩格尔流域进行,并在两(两)个站点进行了采样,即站点A(河流右侧)和站点B(河流左侧)。该研究共进行了13次采样,从2019年5月25日开始,一直持续到2019年11月9日。Palangka Raya大学实验室进行了实验室分析,以确定小叶的类型和数量。结果表明,A站(河流右侧)的小叶藻类群数量为12-13种,多于B站(河流左侧)。B站的小叶藻类群数量为8-9种,怀疑受左侧周围灰色水体的影响,尤其是当水位下降时。Pager河小叶藻的分布特点是:分类群/种数多,丰度低,多样性指数低。河流/泥炭水环境容易发生变化,尤其是人为干扰。这项研究显示了微珠蛋白作为环境破坏指标的潜在用途。
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引用次数: 0
Security Provisioning and Compression of Diverse Genomic Data based on Advanced Encryption Standard (AES) Algorithm 基于高级加密标准(AES)算法的多种基因组数据的安全配置与压缩
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-05-14 DOI: 10.46300/91011.2021.15.14
Raveendra Gudodagi, R. Reddy
Compression of genomic data has gained enormous momentum in recent years because of advances in technology, exponentially growing health concerns, and government funding for research. Such advances have driven us to personalize public health and medical care. These pose a considerable challenge for ubiquitous computing in data storage. One of the main issues faced by genomic laboratories is the 'cost of storage' due to the large data file of the human genome (ranging from 30 GB to 200 GB). Data preservation is a set of actions meant to protect data from unauthorized access or changes. There are several methods used to protect data, and encryption is one of them. Protecting genomic data is a critical concern in genomics as it includes personal data. We suggest a secure encryption and decryption technique for diverse genomic data (FASTA / FASTQ format) in this article. Since we know the sequenced data is massive in bulk, the raw sequenced file is broken into sections and compressed. The Advanced Encryption Standard (AES) algorithm is used for encryption, and the Galois / Counter Mode (GCM) algorithm, is used to decode the encrypted data. This approach reduces the amount of storage space used for the data disc while preserving the data. This condition necessitates the use of a modern data compression strategy. That not only reduces storage but also improves process efficiency by using a k-th order Markov chain. In this regard, no efforts have been made to address this problem separately, from both the hardware and software realms. In this analysis, we support the need for a tailor-made hardware and software ecosystem that will take full advantage of the current stand-alone solutions. The paper discusses sequenced DNA, which may take the form of raw data obtained from sequencing. Inappropriate use of genomic data presents unique risks because it can be used to classify any individual; thus, the study focuses on the security provisioning and compression of diverse genomic data using the Advanced Encryption Standard (AES) Algorithm.
近年来,由于技术的进步、健康问题的指数级增长以及政府对研究的资助,基因组数据的压缩获得了巨大的动力。这些进步促使我们将公共卫生和医疗保健个人化。这对数据存储中的普适计算提出了相当大的挑战。基因组实验室面临的主要问题之一是“存储成本”,因为人类基因组的数据文件很大(从30 GB到200 GB不等)。数据保存是一组旨在保护数据免受未经授权的访问或更改的操作。有几种方法用于保护数据,加密是其中之一。保护基因组数据是基因组学的一个关键问题,因为它包括个人数据。本文提出了一种针对多种基因组数据的安全加密和解密技术(FASTA / FASTQ格式)。因为我们知道已排序的数据是大量的,所以原始的已排序文件被分成几个部分并进行压缩。加密时使用AES (Advanced Encryption Standard)算法,解码时使用GCM (Galois / Counter Mode)算法。这种方法在保留数据的同时减少了用于数据磁盘的存储空间。这种情况要求使用现代数据压缩策略。这不仅减少了存储空间,而且通过使用k阶马尔可夫链提高了处理效率。在这方面,没有作出任何努力分别从硬件和软件领域解决这个问题。在此分析中,我们支持对定制的硬件和软件生态系统的需求,该生态系统将充分利用当前的独立解决方案。本文讨论了已测序的DNA,它可以采取从测序中获得的原始数据的形式。不恰当地使用基因组数据会带来独特的风险,因为它可以用来对任何个体进行分类;因此,本研究的重点是使用高级加密标准(AES)算法对各种基因组数据进行安全配置和压缩。
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引用次数: 0
Structure of Hard And Soft Carapace Exoskeleton Biomaterial Through SEM-EDXRS at Various Stages of Development Scylla paramamosain Mud Crab 用SEM-EDXRS研究硬、软甲壳类外骨骼生物材料在不同发育阶段的结构
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-05-14 DOI: 10.46300/91011.2021.15.15
H. Triajie, S. Andayani, U. Yanuhar, A. Ekawati
Crustacean carapace has various functions which can be seen from the composition of the biomaterial in it. Various concentrations of inorganic biomaterial elements were investigated from the hard carapace and the newly molted (soft-shelled) (Scylla paramamosain) with SEM-EDXRS (scanning electron microscopy-Energy Dispersive X-ray Spectrometer) technique. This study traced the composition of the inorganic elements of the premolt, postmolt, intermolt and soft (exuvium) crab hard carapace tissue of mangrove crabs from the point of view. Various stages of development. Important elements such as C, O2, Mg, P, Ca, S, Na, Si, Cl, and others, are reabsorbed from the carapace into the body tissues to fulfill further needs in soft-shelled crabs and are reused to some extent during formation new carapace. This study provides evidence that, inorganic elements in freshly molted soft carapace crabs are less common than hard carapace crabs
甲壳类动物的甲壳具有多种功能,这可以从甲壳中生物材料的组成看出来。采用SEM-EDXRS(扫描电子显微镜-能量色散x射线光谱仪)技术研究了Scylla硬壳和新脱壳(软壳)(Scylla paramamosain)中不同浓度的无机生物材料元素。本文对红树蟹蜕前、蜕后、蜕间及软(蜕)蟹硬壳组织的无机元素组成进行了研究。不同的发展阶段。重要的元素如C、O2、Mg、P、Ca、S、Na、Si、Cl等从甲壳中被重吸收到身体组织中,以满足软壳蟹进一步的需要,并在形成新甲壳的过程中得到一定程度的重复利用。本研究提供了新脱壳软壳蟹体内无机元素含量低于硬壳蟹的证据
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引用次数: 1
The Features of Antigen Prevalence of Rhesus System in Donor Population 供体人群恒河猴系统抗原流行特征分析
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-04-15 DOI: 10.46300/91011.2021.15.10
M. Nagervadze, L. Akvlediani, I. Tsintsadze, T. Koiava, R. Loria, S. Tskvitinidze, R. Khukhunaishvili, M. Koridze
Research materials and methods. 852 voluntary Georgian blood donors have been typed on red blood cells group antigens. The research materials have taken from the diagnostic laboratory of Health Centre of Batumi (Georgia republic). The immunoserological methods with monoclonal anti –AB, -B, -A, A1, -A2 (H), -C, -c, - D, -E, -e (Bio-Rad, cypress diagnostics) antibodies was used for typing blood. The ID cards, such as ABO/D + Reverse Grouping (Bio-Rad) were also used for typing of erythrocyte antigens. Result. Prevalence of Rh system antigens in the studied group is looks like so: e antigens – 94,6%, c antigens -85%, C-68,03, E antigens - 38,07%. The majority (84%) of the studied donors are Rh-positive (n=719), 133 (16%) donors are Rh-negative. C antigen most common is present in the combination with D antigen. 65, 8 % case donors had CD+ combination (n=561). E antigen in most cases is presented with a combination of D antigen. 36, 9% of the studied donors (n=306) had ED+ combination. A miserable number of studied donors had CD - (2,23%; n=19) and ED - (1,17%; n=9) combinations. We have studied the Rh phenotypes prevalence in blood donors. According to RHD, RHC, and RHE gene loci, there are 18 theoretically possible phenotypical groups. Among them half (nine) are Rh-positive and the rest of them are Rh-negative. The Rh-positive phenotypes are: CDE; CDEe; CDe; CcDE; CcDEe; CcDe; ccDE; cDEe and cDe. Rh-negative phenotypes are CdE; CdEe; Cde; CcdE; CcdEe; Ccde; cdE; cdEe; cde. We allocated 17 Rh phenotypes among studied donors. Only one phenotype CdE, which belongs to Rh negative group, was not present in studied donors. Other 17 phenotypes showed different frequencies. Some of them were only in a single case, for example, cdEe, cdE, CdEe phenotypes had only one donor. The majority of the phenotype in he studied donors (27,8±1,53%) was CcDe (n=237). CcDEe -19,3±1,35% (n=165); 125 donors have CDe phenotype (14,6±1,2); The frequency of cde was 13,1±1,5%, which means that 112 studied donors belonged to this phenotype group; 87 studied donors had cDEe phenotype characteristics (10,2%); The frequency of cDe was 4,9% (n=42); 19 donors had CDEe phenotype. Other phenotypes (CDE, Cde, CcdEe, Ccde) frequency was very low. Conclusion. Our studied donors are characterized by rather high polymorphism. The Georgian donor’s population is heterogenic, especially high heterogeneity are shown in Rh positive phenotypes. The obtained data is vital importance for the preparation of whole blood or certain blood components for the purpose of their rational usage in blood transfusion.
研究材料和方法。852名格鲁吉亚自愿献血者接受了红细胞群抗原的分型。研究材料取自巴统保健中心(格鲁吉亚共和国)诊断实验室。采用单克隆抗- ab、- b、- a、A1、- a2 (H)、-c、-c、- D、-e、-e (Bio-Rad、cypress diagnostics)抗体的免疫血清学方法进行分型。同时还采用ABO/D +反向分组(Bio-Rad)等身份证进行红细胞抗原分型。结果。Rh系统抗原在研究组的患病率如下:e抗原- 94.6%,c抗原-85%,c -68,03, e抗原- 38,07%。大多数(84%)供者为rh阳性(n=719), 133(16%)供者为rh阴性。C抗原最常见的是与D抗原结合。65.8%的供体为CD+组合(n=561)。E抗原在大多数情况下表现为与D抗原的结合。36.9%的供者(306例)有ED+联合。在被研究的供者中,有相当一部分人患有乳糜泻(2,23%;n=19)和ED - (1,17%;n = 9)组合。我们研究了Rh表型在献血者中的患病率。根据RHD、RHC和RHE基因位点,理论上有18个可能的表型组。其中一半(9个)为rh阳性,其余为rh阴性。rh阳性表型为:CDE;CDEe;CDe;CcDE;CcDEe;CcDe;ccDE;cDEe和cDe。rh阴性表型为CdE;CdEe;Cde;CcdE;CcdEe;Ccde;cdE;cdEe;cde。我们在研究的供体中分配了17种Rh表型。只有一种属于Rh阴性组的表型CdE在研究供体中不存在。其他17种表型表现出不同的频率。有的只在一个病例中出现,如cdEe、cdE、cdEe表型只有一个供体。本研究供者的主要表型(27.8±1.53%)为CcDe (n=237)。CcDEe -19,3±1,35% (n=165);125例供体有CDe表型(14.6±1,2);cde的发生率为13.1±1.5%,即112例供体属于该表型组;87名研究供体具有cDEe表型特征(10.2%);cDe发生率为4.9% (n=42);19名供体有CDEe表型。其他表型(CDE、CDE、CcdEe、Ccde)发生率极低。结论。我们研究的供体具有相当高的多态性。格鲁吉亚供体人群是异质的,特别是Rh阳性表型显示出高度异质性。所得数据对全血或某些血液成分的制备及其在输血中的合理使用具有重要意义。
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引用次数: 0
Policy Priorities For Improving The Quality Of Slum Settlements In Banjarmasin City, South Kalimantan Province, Indonesia 改善印尼南加里曼丹省班加马辛市贫民窟住区质量的政策重点
Q4 Biochemistry, Genetics and Molecular Biology Pub Date : 2021-04-08 DOI: 10.46300/91011.2021.15.9
F. Yusran
Banjarmasin city faces almost the same problems as other big cities in the world, namely slum settlements. One of the factors in the formation of slum settlements in Banjarmasin city is urbanization. The population that continues to increase due to the flow of urbanization causes urban areas to have a very urgent problem, namely the provision of housing facilities. The high price of land in the city center and low-per capita income cause people to tend to look for settlements in suburban areas with inadequate environments and supporting facilities. This research aims to identify the conditions of slum settlements in Banjarmasin City and formulate policy priorities to improve the quality of slum settlements in Banjarmasin City. To answer all these objectives, an integrated settlement management system can be implemented. Comprehensive integration between office holders, stakeholders, and residents will produce a draft policy and slum management scenario. In addition, the policy for sustainable management of slum settlements in Banjarmasin City is also designed using the AHP (Analytical Hierarchy Process) approach. The slum settlements in Banjarmasin city are generally caused by geographical location, where most of them are river and swamp areas. Slums are getting worse because of the bad sanitation system. Ecological factor is the main priority factor in improving the quality of slum settlements. This is because if the slum area is able to maintain its ecology, it will be able to overcome disturbances or pressure, maintain or regain its function and shape. Based on AHP analysis, it is also known that the policy priority in improving the quality of slum settlements is by redevelopment. This effort is the rearrangement of part or all of the area for the purpose of managing the slum settlements in Banjarmasin city.
班加马辛市面临着与世界上其他大城市几乎相同的问题,即贫民窟。Banjarmasin市贫民窟住区形成的因素之一是城市化。由于城市化的发展,人口不断增加,导致城市地区出现了一个非常紧迫的问题,即住房设施的提供。城市中心地价高,人均收入低,导致人们倾向于在环境和配套设施不足的郊区寻找定居点。本研究旨在确定班贾马辛市贫民窟住区的状况,并制定政策重点,以提高班贾马辛市贫民窟住区的质量。为了实现所有这些目标,可以实施综合结算管理系统。办公室负责人、利益相关者和居民之间的全面整合将产生一份政策草案和贫民窟管理方案。此外,班贾尔马辛市贫民窟住区可持续管理政策也采用AHP(层次分析法)方法设计。班贾尔马辛市的贫民窟定居点一般是由地理位置造成的,其中大多数是河流和沼泽地区。由于糟糕的卫生系统,贫民窟变得越来越糟。生态因素是改善贫民窟住区质量的主要优先因素。这是因为如果贫民窟能够保持其生态,它就能够克服干扰或压力,保持或恢复其功能和形状。通过层次分析法可知,改善贫民窟住区质量的政策重点是再开发。这项工作是重新安排部分或全部地区,以便管理班贾尔马辛市的贫民窟住区。
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引用次数: 1
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International Journal of Biology and Biomedical Engineering
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