Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.9
E. Fatullaev, V. Bezrodnyi, I. Neelov
Biocompatible peptide dendrimers and dendrigrafts have useful properties for application in biomedicine. In previous papers the computational approach for study lysine dendrimers and dendrigrafts as well as their complexes with various medical peptides was used. In this paper the comparison of complex formation between molecules of therapeutic AEDG tetrapeptide and novel K2R peptide dendrimer or DG2 dendrigraft of near the same size and charge was fulfilled. The systems consisting of 16 therapeutic AEDG tetrapeptide molecules and one dendrimer or one dendrigraft were studied by molecular dynamics simulation. Full atomic models of these molecules in water with explicit counterions were used for this goal. First of all, the process of complex formation was studied. It was obtained that peptide molecules were attracted by both branched molecules and were quickly adsorbed by them. Times of complexes formation as well as size, anisotropy and structure of each complex were calculated. It was demonstrated that both K2R dendrimer and DG2 dendrigraft are effective for complexation of these peptide molecules but new dendrimer complex is more stable than dendrigraft complex because it has almost twice more hydrogen bonds with peptide molecules and 33% more ion pairs with their charged groups.
{"title":"MD Simulation of AEDG Peptide Complexes with New K2R Dendrimer and Dendrigraft","authors":"E. Fatullaev, V. Bezrodnyi, I. Neelov","doi":"10.46300/91011.2022.16.9","DOIUrl":"https://doi.org/10.46300/91011.2022.16.9","url":null,"abstract":"Biocompatible peptide dendrimers and dendrigrafts have useful properties for application in biomedicine. In previous papers the computational approach for study lysine dendrimers and dendrigrafts as well as their complexes with various medical peptides was used. In this paper the comparison of complex formation between molecules of therapeutic AEDG tetrapeptide and novel K2R peptide dendrimer or DG2 dendrigraft of near the same size and charge was fulfilled. The systems consisting of 16 therapeutic AEDG tetrapeptide molecules and one dendrimer or one dendrigraft were studied by molecular dynamics simulation. Full atomic models of these molecules in water with explicit counterions were used for this goal. First of all, the process of complex formation was studied. It was obtained that peptide molecules were attracted by both branched molecules and were quickly adsorbed by them. Times of complexes formation as well as size, anisotropy and structure of each complex were calculated. It was demonstrated that both K2R dendrimer and DG2 dendrigraft are effective for complexation of these peptide molecules but new dendrimer complex is more stable than dendrigraft complex because it has almost twice more hydrogen bonds with peptide molecules and 33% more ion pairs with their charged groups.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42207711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.2
Bratashova Tatyana Sergeevna, Zakharkina Natalya Ivanovna, Shcherbakova Elena Nikolaevna, Safonov Vladimir Aleksandrovich
The study of indicators characterizing the processes associated with the acclimatization of birds in new biogeochemical conditions is of interest in connection with the prospects of the poultry industry in the Astrakhan Region, where the lack of important trace elements in soils and plant feeds: Se, I, Co, is observed. In the presented study, the main hematological and biochemical parameters of blood and mineral metabolism were determined in 2 groups of chickens of the Moscow black breed: imported to the Astrakhan Region from Moscow and kept in the Moscow Region. The analyses revealed strong differences (P<0.01) in indicators of two groups. The acclimatized birds were characterized by low levels of red blood cells and hemoglobin in the blood, as well as a higher content of white blood cells than in the second group. The chickens had impaired lipid and protein metabolism. A 71.3% increase in the level of total sugar most likely indicated a stress state of birds. Compared with the chickens in the Moscow Region, the level of calcium in their blood was 32.4% lower, phosphorus – 12.9%. To a large extent, a decrease in the levels of iodine and selenium – by 5.3 and 5.2 times, respectively, was observed. Thus, in the absence of external changes, acclimatized chickens are subject to a latent form of combined I- and Se-hypomicroelementosis. At the same time, a drop in egg productivity by 19% is the recorded fact. The necessity to adapt to the new climatic conditions of the Lower Volga region for birds, combined with a lack of important trace elements, can cause increased oxidative stress in acclimatized birds. Based on the results of the study, the use of feed additives that make up for the deficiency of necessary trace elements is recommended.
{"title":"Study of Hematological Characteristics and Mineral Metabolism of Moscow Black Chickens in the Process of Acclimatization in the Astrakhan Region","authors":"Bratashova Tatyana Sergeevna, Zakharkina Natalya Ivanovna, Shcherbakova Elena Nikolaevna, Safonov Vladimir Aleksandrovich","doi":"10.46300/91011.2022.16.2","DOIUrl":"https://doi.org/10.46300/91011.2022.16.2","url":null,"abstract":"The study of indicators characterizing the processes associated with the acclimatization of birds in new biogeochemical conditions is of interest in connection with the prospects of the poultry industry in the Astrakhan Region, where the lack of important trace elements in soils and plant feeds: Se, I, Co, is observed. In the presented study, the main hematological and biochemical parameters of blood and mineral metabolism were determined in 2 groups of chickens of the Moscow black breed: imported to the Astrakhan Region from Moscow and kept in the Moscow Region. The analyses revealed strong differences (P<0.01) in indicators of two groups. The acclimatized birds were characterized by low levels of red blood cells and hemoglobin in the blood, as well as a higher content of white blood cells than in the second group. The chickens had impaired lipid and protein metabolism. A 71.3% increase in the level of total sugar most likely indicated a stress state of birds. Compared with the chickens in the Moscow Region, the level of calcium in their blood was 32.4% lower, phosphorus – 12.9%. To a large extent, a decrease in the levels of iodine and selenium – by 5.3 and 5.2 times, respectively, was observed. Thus, in the absence of external changes, acclimatized chickens are subject to a latent form of combined I- and Se-hypomicroelementosis. At the same time, a drop in egg productivity by 19% is the recorded fact. The necessity to adapt to the new climatic conditions of the Lower Volga region for birds, combined with a lack of important trace elements, can cause increased oxidative stress in acclimatized birds. Based on the results of the study, the use of feed additives that make up for the deficiency of necessary trace elements is recommended.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42320389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.12
I. Medvedev, V. Karpov, O. Makurina, M. V. Eremin, A. Dorontsev, F. R. Sibgatulina, D. A. Ivanov
Regular dosed physical activity in all cases has a tonic and healing effect on a person. Feasible muscle activity helps to improve the function of the heart, lungs, blood vessels and the nervous system. In martial arts, the reactivity of the vestibular apparatus is of great importance, providing the flow of information about the current position of the body in space, the success of movement in it and maintaining the stability of the posture due to the effective redistribution of muscle tone. Purpose of the work: to find out the dependence of the reaction of the cardiovascular system to the arising vestibular irritation in different types of martial arts. Martial arts classes help to increase the degree of vestibular stability. The statokinetic stability is very pronounced and increases in the course of hand-to-hand combat, which has a lot of moments with different severity of angular accelerations. The peculiarities of motor activity in any kind of martial arts inevitably affect the peculiarities of the reaction to the test with a change in the position of the head.
{"title":"Functional Reaction of the Cardiovascular System to Irritation of Vestibular Receptors in Students Engaged in Different Types of Martial Arts","authors":"I. Medvedev, V. Karpov, O. Makurina, M. V. Eremin, A. Dorontsev, F. R. Sibgatulina, D. A. Ivanov","doi":"10.46300/91011.2022.16.12","DOIUrl":"https://doi.org/10.46300/91011.2022.16.12","url":null,"abstract":"Regular dosed physical activity in all cases has a tonic and healing effect on a person. Feasible muscle activity helps to improve the function of the heart, lungs, blood vessels and the nervous system. In martial arts, the reactivity of the vestibular apparatus is of great importance, providing the flow of information about the current position of the body in space, the success of movement in it and maintaining the stability of the posture due to the effective redistribution of muscle tone. Purpose of the work: to find out the dependence of the reaction of the cardiovascular system to the arising vestibular irritation in different types of martial arts. Martial arts classes help to increase the degree of vestibular stability. The statokinetic stability is very pronounced and increases in the course of hand-to-hand combat, which has a lot of moments with different severity of angular accelerations. The peculiarities of motor activity in any kind of martial arts inevitably affect the peculiarities of the reaction to the test with a change in the position of the head.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44366569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.15
Alexander A. Ermakov
The Article describes the peculiarities of colour shades in the Golden Retriever breed. The separate attention was given to nowadays existence of different standards of coat colour in this breed across the world, and these standards admit a broad variety of different shades in golden colour. Herewith it has been established that the white pigmentation colour of golden retrievers is unallowable in any of “Kennel Club” standards valid for today. The special focus was put to the genotype of breed, which presupposes the existence of double recessive gene (e/e) that predetermines creamy shade of coat colour. It was discovered that exactly the gene MC1R, its autosomal-recessive inheritance, plays the leading role in defining the coat colour of dogs and in the exterior of the breed. It was assumed how and why this genotype is widespread in population, at which extent sub-populations are distinguished (American and English-European ones), and also there was the option offered related to breeding the pure line on the basis of knowledge about karyotype of dogs, that were obtained in a course of predicative screening of E-locus.
{"title":"Peculiarities of Inheriting Coat Colour Shades in the Breed “Golden Retriever”","authors":"Alexander A. Ermakov","doi":"10.46300/91011.2022.16.15","DOIUrl":"https://doi.org/10.46300/91011.2022.16.15","url":null,"abstract":"The Article describes the peculiarities of colour shades in the Golden Retriever breed. The separate attention was given to nowadays existence of different standards of coat colour in this breed across the world, and these standards admit a broad variety of different shades in golden colour. Herewith it has been established that the white pigmentation colour of golden retrievers is unallowable in any of “Kennel Club” standards valid for today. The special focus was put to the genotype of breed, which presupposes the existence of double recessive gene (e/e) that predetermines creamy shade of coat colour. It was discovered that exactly the gene MC1R, its autosomal-recessive inheritance, plays the leading role in defining the coat colour of dogs and in the exterior of the breed. It was assumed how and why this genotype is widespread in population, at which extent sub-populations are distinguished (American and English-European ones), and also there was the option offered related to breeding the pure line on the basis of knowledge about karyotype of dogs, that were obtained in a course of predicative screening of E-locus.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46959787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.19
M. A. Zainaro, Ridwan Ridwan, Rias Tusianah, Sudjarwo Sudjarwo, U. C. Isnainy, Albet Maydiantoro, Tubagus Ali Rachman Puja Kesuma, H. Hariri, Aprina Aprina
Diabetes mellitus (DM) is a slowly deadly disease. Indonesia has the 4th highest number of diabetes mellitus after China, India and the United States. People with diabetes have grown from 8.4 million in 2000 and will become 21.3 million in 2030. This study aims to determine the relationship between body movement and blood sugar levels in patients with type 2 diabetes mellitus. This type of research is quantitative, with a design analytical research and cross-sectional approach. The sample of this study was 131 people with the criteria for suffering from type 2 diabetes mellitus. Data collection used the Global Body Movement Questionnaire (GPAQ) questionnaire, and the statistical test used was the Chi-Square statistical test. The results showed that there was a relationship between physical activity and blood sugar levels in patients with type 2 diabetes mellitus, so it is recommended that DM patients should routinely carry out body movements and control blood sugar levels in health care facilities and take advantage of health services such as health workers if they experience problems in performing body movements and follow a diabetic diet according to the advice of a nutritionist. In-depth conclusions and implications are discussed.
{"title":"Physical Activity and Blood Sugar Levels in People with Diabetes Mellitus: Evidence from Indonesia","authors":"M. A. Zainaro, Ridwan Ridwan, Rias Tusianah, Sudjarwo Sudjarwo, U. C. Isnainy, Albet Maydiantoro, Tubagus Ali Rachman Puja Kesuma, H. Hariri, Aprina Aprina","doi":"10.46300/91011.2022.16.19","DOIUrl":"https://doi.org/10.46300/91011.2022.16.19","url":null,"abstract":"Diabetes mellitus (DM) is a slowly deadly disease. Indonesia has the 4th highest number of diabetes mellitus after China, India and the United States. People with diabetes have grown from 8.4 million in 2000 and will become 21.3 million in 2030. This study aims to determine the relationship between body movement and blood sugar levels in patients with type 2 diabetes mellitus. This type of research is quantitative, with a design analytical research and cross-sectional approach. The sample of this study was 131 people with the criteria for suffering from type 2 diabetes mellitus. Data collection used the Global Body Movement Questionnaire (GPAQ) questionnaire, and the statistical test used was the Chi-Square statistical test. The results showed that there was a relationship between physical activity and blood sugar levels in patients with type 2 diabetes mellitus, so it is recommended that DM patients should routinely carry out body movements and control blood sugar levels in health care facilities and take advantage of health services such as health workers if they experience problems in performing body movements and follow a diabetic diet according to the advice of a nutritionist. In-depth conclusions and implications are discussed.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44768132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.18
Wachiraporn Aiamklin, Y. Jewajinda, Yunyong Punsawad
This paper proposes the development of automatic sleep stage detection by using physiological signals. We aim to develop an application to assist drivers after drowsiness or fatigue detection by a commercial driver vigilance system. The proposed method used a low-cost surface electromyography (EMG) device for sleep stage detection. We investigate skeletal muscle location and EMG features from sleep stage 2 to provide an EMG-based nap monitoring system. The results showed that using only one channel of a bipolar EMG signal from an upper trapezius muscle with median power frequency can achieve 84% accuracy. We implement a MyoWare muscle sensor into the proposed nap monitoring device. The results showed that the proposed system is feasible for detecting sleep stages and waking up the napper. A combination of EMG and electroencephalogram (EEG) signals might be yield a high system performance for nap monitoring and alarm system. We will prototype a portable device to connect the application to a smartphone and test with a target group, such as truck drivers and physicians.
{"title":"Light Sleep Detection based on Surface Electromyography Signals for Nap Monitoring","authors":"Wachiraporn Aiamklin, Y. Jewajinda, Yunyong Punsawad","doi":"10.46300/91011.2022.16.18","DOIUrl":"https://doi.org/10.46300/91011.2022.16.18","url":null,"abstract":"This paper proposes the development of automatic sleep stage detection by using physiological signals. We aim to develop an application to assist drivers after drowsiness or fatigue detection by a commercial driver vigilance system. The proposed method used a low-cost surface electromyography (EMG) device for sleep stage detection. We investigate skeletal muscle location and EMG features from sleep stage 2 to provide an EMG-based nap monitoring system. The results showed that using only one channel of a bipolar EMG signal from an upper trapezius muscle with median power frequency can achieve 84% accuracy. We implement a MyoWare muscle sensor into the proposed nap monitoring device. The results showed that the proposed system is feasible for detecting sleep stages and waking up the napper. A combination of EMG and electroencephalogram (EEG) signals might be yield a high system performance for nap monitoring and alarm system. We will prototype a portable device to connect the application to a smartphone and test with a target group, such as truck drivers and physicians.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43129778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.4
S. Mahendra, Viswanath Talasila, A. G. Dutt, Mukund Balaji, Abhishek C. Mouli
Functional electrical stimulation is an assistive technique that utilizes electrical discharges to produce functional movements in patients suffering from neurological impairments. In this work, a biphasic, programmable current- controlled functional electrical stimulator system is designed to enable hand grasping facilitated by wrist flexion. The developed system utilizes an operational amplifier based current source and is supported by a user interface to adjust stimulation parameters. The device is integrated with an accelerometer to measure the degree of stimulated movement. The system is validated, firstly, on two passive electrical loads and subsequently on four healthy volunteers. The device is designed to deliver currents between 0-30mA, and the error between the measured current and simulated current for two loads were -0.967±0.676mA and -0.995±0.97mA. The angular data from the accelerometer provided information regarding variations in movement between the subjects. The architecture of the proposed system is such that it can, in principle, automatically adjust the parameters of simulation to induce the desired movement optimally by measuring a stimulated movement artifact (e.g., angular position) in real time.
{"title":"A Functional Electrical Stimulator to Enable Grasping Through Wrist Flexion","authors":"S. Mahendra, Viswanath Talasila, A. G. Dutt, Mukund Balaji, Abhishek C. Mouli","doi":"10.46300/91011.2022.16.4","DOIUrl":"https://doi.org/10.46300/91011.2022.16.4","url":null,"abstract":"Functional electrical stimulation is an assistive technique that utilizes electrical discharges to produce functional movements in patients suffering from neurological impairments. In this work, a biphasic, programmable current- controlled functional electrical stimulator system is designed to enable hand grasping facilitated by wrist flexion. The developed system utilizes an operational amplifier based current source and is supported by a user interface to adjust stimulation parameters. The device is integrated with an accelerometer to measure the degree of stimulated movement. The system is validated, firstly, on two passive electrical loads and subsequently on four healthy volunteers. The device is designed to deliver currents between 0-30mA, and the error between the measured current and simulated current for two loads were -0.967±0.676mA and -0.995±0.97mA. The angular data from the accelerometer provided information regarding variations in movement between the subjects. The architecture of the proposed system is such that it can, in principle, automatically adjust the parameters of simulation to induce the desired movement optimally by measuring a stimulated movement artifact (e.g., angular position) in real time.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42803468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.17
Eugenia D. Namiot, Maxim Khakhin
MicroRNAs are non-coding molecules that play a significant role in the development of the disease. MicroRNAs can act as biomarkers or independently lead to the development of a disease. Due to the large numbers of microRNAs, most of the current works focus on the creation of a new way of microRNA clustering or grouping. Today, there are a huge number of different databases that distribute open microRNAs into groups. The problem is that there is no way to evaluate such databases and created clusters. In this work, we propose a new method for assessing the distribution of microRNAs in a cluster, which in the future can be used to predict new sequential ones capable of causing disease. The proposed method can also be used for a better understanding of the mechanisms of various diseases. Since cardiovascular diseases rank first in terms of the number of deaths, they were chosen as the analyzed ones. The Human microRNA Disease Database was used as an analyzed database in this work. The obtained results show that the proposed method can analyze the created databases and can be used in further practice. The proposed model makes it possible to predict new microRNAs for given diagnoses.
{"title":"Data Analysis for microRNA and Related Diagnoses","authors":"Eugenia D. Namiot, Maxim Khakhin","doi":"10.46300/91011.2022.16.17","DOIUrl":"https://doi.org/10.46300/91011.2022.16.17","url":null,"abstract":"MicroRNAs are non-coding molecules that play a significant role in the development of the disease. MicroRNAs can act as biomarkers or independently lead to the development of a disease. Due to the large numbers of microRNAs, most of the current works focus on the creation of a new way of microRNA clustering or grouping. Today, there are a huge number of different databases that distribute open microRNAs into groups. The problem is that there is no way to evaluate such databases and created clusters. In this work, we propose a new method for assessing the distribution of microRNAs in a cluster, which in the future can be used to predict new sequential ones capable of causing disease. The proposed method can also be used for a better understanding of the mechanisms of various diseases. Since cardiovascular diseases rank first in terms of the number of deaths, they were chosen as the analyzed ones. The Human microRNA Disease Database was used as an analyzed database in this work. The obtained results show that the proposed method can analyze the created databases and can be used in further practice. The proposed model makes it possible to predict new microRNAs for given diagnoses.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41664918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.46300/91011.2022.16.1
D. Veena, A. Jatti, M. Vidya, Revan Joshi, Srikar Gade
Panoramic dental x-ray, a two-dimensional dental x-ray that captures the entire mouth in a single image, is used for the initial screening of various dental anomalies. One such is Jaw bone cyst, which, if not identified earlier, may lead to complications which in turn may lead to disfigurement and loss of function. Hence processing of radiographic images plays a vital role in identifying and locating the cystic region and extracting related features to assist clinical experts in further analysis. Objective: To develop an application of active contour model, known as Geodesic Active Contour, to generate Panoramic Dental X-Ray, a single 2 D X-ray image of the entire mouth highlighting the dental specifications. Methods: The process involves the image conversion from the OPG image into grayscale, Contrast adjustment using intensity level slicing, edge smoothing, segmentation, and cyst segmentation by Morphological Geodesic Active Contour to obtain the results. Hence processing of radiographic images plays a vital role in identifying and locating the cystic region. It is crucial in extracting related features to assist clinical experts in further analysis. Conclusion: When efficient and accurate diagnostic methods exist, the treatment and cure become easy and concrete. Based on the morphological snake and level sets, it aims at identifying the boundary by minimizing the energy. Results: Using the structural similarity index, an accuracy of 97.6% is obtained. Advances in Knowledge: This process is advantageous as it is simpler, faster, and does not suffer from instability problems. Morphological methods improve their functional gradient descent by improving stability and speed. The hysteresis algorithm exhibits better edge detection performance, a significant reduction in computational time and scalability.
{"title":"A Novel Approach towards Automatic Contour Identification of Jaw Cysts from Digital Panoramic Radiographs to improvise the Treatment planning","authors":"D. Veena, A. Jatti, M. Vidya, Revan Joshi, Srikar Gade","doi":"10.46300/91011.2022.16.1","DOIUrl":"https://doi.org/10.46300/91011.2022.16.1","url":null,"abstract":"Panoramic dental x-ray, a two-dimensional dental x-ray that captures the entire mouth in a single image, is used for the initial screening of various dental anomalies. One such is Jaw bone cyst, which, if not identified earlier, may lead to complications which in turn may lead to disfigurement and loss of function. Hence processing of radiographic images plays a vital role in identifying and locating the cystic region and extracting related features to assist clinical experts in further analysis. Objective: To develop an application of active contour model, known as Geodesic Active Contour, to generate Panoramic Dental X-Ray, a single 2 D X-ray image of the entire mouth highlighting the dental specifications. Methods: The process involves the image conversion from the OPG image into grayscale, Contrast adjustment using intensity level slicing, edge smoothing, segmentation, and cyst segmentation by Morphological Geodesic Active Contour to obtain the results. Hence processing of radiographic images plays a vital role in identifying and locating the cystic region. It is crucial in extracting related features to assist clinical experts in further analysis. Conclusion: When efficient and accurate diagnostic methods exist, the treatment and cure become easy and concrete. Based on the morphological snake and level sets, it aims at identifying the boundary by minimizing the energy. Results: Using the structural similarity index, an accuracy of 97.6% is obtained. Advances in Knowledge: This process is advantageous as it is simpler, faster, and does not suffer from instability problems. Morphological methods improve their functional gradient descent by improving stability and speed. The hysteresis algorithm exhibits better edge detection performance, a significant reduction in computational time and scalability.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48299620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-04DOI: 10.46300/91011.2021.15.47
T. Kitamura
We investigated the dispersion relations of the triple-chambered cochlea separated by the basilar membrane and the Reissner's membrane. The slow waves can propagate on the basilar membrane (basilar membrane mode), and also on the Reissner’s membrane (Reisnner’s membrane mode). Most of the previous studies have focused on the mechanics of vibration of the basilar membrane and there are only a few studies on the wave propagation on Reissner’s membrane. In this study, we focused particularly on the Reissner's membrane mode among the many propagation modes and evanescent modes that the structure supports. We analyzed the dispersion of the Reissner’s membrane mode and the basilar membrane mode, and studied their dependency on the position along the cochlea. We also studied how the distance between the Reissner's membrane and the basilar membrane affects the dispersion relations.
{"title":"Dispersion Relation of Triple-chambered Cochlea","authors":"T. Kitamura","doi":"10.46300/91011.2021.15.47","DOIUrl":"https://doi.org/10.46300/91011.2021.15.47","url":null,"abstract":"We investigated the dispersion relations of the triple-chambered cochlea separated by the basilar membrane and the Reissner's membrane. The slow waves can propagate on the basilar membrane (basilar membrane mode), and also on the Reissner’s membrane (Reisnner’s membrane mode). Most of the previous studies have focused on the mechanics of vibration of the basilar membrane and there are only a few studies on the wave propagation on Reissner’s membrane. In this study, we focused particularly on the Reissner's membrane mode among the many propagation modes and evanescent modes that the structure supports. We analyzed the dispersion of the Reissner’s membrane mode and the basilar membrane mode, and studied their dependency on the position along the cochlea. We also studied how the distance between the Reissner's membrane and the basilar membrane affects the dispersion relations.","PeriodicalId":53488,"journal":{"name":"International Journal of Biology and Biomedical Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42712912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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