Few sectors in the global economy need deep decarbonization as much as heavy industry, which is currently the largest and fastest growing source of global carbon emissions. Based on an original dataset of 111 expert interviews and 52 site visits, this paper asks: what sociotechnical pathways, capabilities, and regional innovation systems are emerging to support industrial decarbonization? It combines and applies insights from evolutionary economic geography and transitions studies, such as sociotechnical capabilities and learning, as well as spatial frameworks such as challenge-oriented regional innovation systems (CoRIS) and green industrial restructuring. It utilizes these collective concepts of pathways, capabilities and CoRIS to explore the organizational and technological, individual, and systems level dimensions of industrial decarbonization efforts ongoing across Great Britain. We find that within industrial net-zero clusters, spatial and technological proximities are being effectively leveraged, especially through new forms of networking, collaboration, and partnerships. CoRIS provides the basis for greater reflection on perennial transitions issues, both within and across clusters, related to incumbency and innovation, in addition to spotlighting emergent issues such as light versus deep green restructuring and incremental versus transformative change. In simpler terms, industrial decarbonization unfolds as a multi-scalar process. Industrial decarbonization exhibits both incremental and transformative patterns of change. Industrial decarbonization lastly involves dynamic processes that coevolve across a spectrum of sociotechnical attributes.