Zeitschrift fur Medizinische Physik最新文献

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Erratum to “The role of Monte Carlo simulation in understanding the performance of proton computed tomography” [Z Med Phys 32 (2022) 23–38] 对 "蒙特卡罗模拟在了解质子计算机断层扫描性能方面的作用 "的勘误 [Z Med Phys 32 (2022) 23-38]。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.012

George Dedes , Jannis Dickmann , Valentina Giacometti , Simon Rit , Nils Krah , Sebastian Meyer , Vladimir Bashkirov , Reinhard Schulte , Robert P. Johnson , Katia Parodi , Guillaume Landry

引用次数: 0

Erratum to “Volumetric 23Na single and triple-quantum imaging at 7T: 3D-CRISTINA” [Z Med Phys 32 (2022) 199–208] 对 "7T 下的容积 23Na 单量子和三量子成像：3D-CRISTINA "的勘误 [Z Med Phys 32 (2022) 199-208]。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.008

Michaela A.U. Hoesl , Lothar R. Schad , Stanislas Rapacchi

引用次数: 0

Non-contrast free-breathing liver perfusion imaging using velocity selective ASL combined with prospective motion compensation 利用速度选择性 ASL 结合前瞻性运动补偿进行非对比自由呼吸肝脏灌注成像。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.06.001

Ke Zhang , Simon M.F. Triphan , Mark O. Wielpütz , Christian H. Ziener , Mark E. Ladd , Heinz-Peter Schlemmer , Hans-Ulrich Kauczor , Oliver Sedlaczek , Felix T. Kurz

Purpose

To apply velocity selective arterial spin labeling (VSASL) combined with a navigator-based (NAV) prospective motion compensation method for a free–breathing liver perfusion measurement without contrast agent.

Methods

Sinc-modulated Velocity Selective Inversion (sinc-VSI) pulses were applied as labeling and control pulses. In order to account for respiratory motion, a navigator was employed in the form of a single gradient-echo projection readout, located at the diaphragm along the inferior-superior direction. Prior to each transverse imaging slice of the spin-echo EPI based readouts, navigator and fat suppression were incorporated. Motion data was obtained from the navigator and transmitted back to the sequence, allowing real-time adjustments to slice positioning. The sinc-VSI without velocity-selective gradients during the control condition but with velocity-selective gradients along all three directions during labeling was chosen for the VSASL. The VSASL was compared with pseudo-continuous ASL (pCASL) methods, which selectively tagged the moving spins using a tagging plane placed at the portal vein and hepatic artery.

Results

The motion caused by respiratory activity was effectively computed using the navigator signal. The coefficients of variation (CoV) of average liver voxel in NAV were significantly decreased when compared to breath-hold (BH), with an average reduction of 29.4 ± 18.44% for control images, and 29.89 ± 20.83% for label images (p < 0.001). The resulting maps of normalized ASL signal (normalized to M₀) showed significantly higher perfusion weightings in the NAV-compensated VSASL, when compared to the NAV-compensated pCASL techniques.

Conclusions

This study demonstrates the feasibility of using a navigator-based prospective motion compensation technique in conjunction with VSASL for the measurement of liver perfusion without the use of contrast agents while allowing for free-breathing.

目的：将速度选择性动脉自旋标记（VSASL）与基于导航仪的前瞻性运动补偿方法相结合，用于不使用造影剂的自由呼吸肝脏灌注测量：方法：采用锌调制速度选择性反转（sinc-VSI）脉冲作为标记和控制脉冲。为了考虑呼吸运动，采用了一个导航仪，其形式为单个梯度回波投影读数，位于膈肌沿下-上方向。在基于自旋回波 EPI 的读数的每个横向成像切片之前，都加入了导航仪和脂肪抑制。从导航仪获取运动数据并传回序列，以便实时调整切片定位。VSASL 采用的 sinc-VSI 在控制条件下没有速度选择梯度，但在标记时沿所有三个方向都有速度选择梯度。VSASL 与伪连续 ASL（pseudo-continuous ASL，pCASL）方法进行了比较，后者是通过放置在门静脉和肝动脉处的标记平面选择性标记移动的自旋：结果：利用导航信号可有效计算呼吸活动引起的运动。与屏气（BH）相比，NAV中平均肝脏体素的变异系数（CoV）明显降低，对照图像平均降低29.4±18.44%，标签图像平均降低29.89±20.83%（P 0），与NAV补偿的pCASL技术相比，NAV补偿的VSASL显示出明显更高的灌注权重：这项研究证明了将基于导航仪的前瞻性运动补偿技术与 VSASL 结合使用，在不使用造影剂、允许自由呼吸的情况下测量肝脏灌注的可行性。

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引用次数: 0

Erratum to “Can Generative Adversarial Networks help to overcome the limited data problem in segmentation?” [Z Med Phys 32 (2022) 361–368] 对 "生成式对抗网络能否帮助克服分割中的数据有限问题？"的勘误 [Z Med Phys 32 (2022) 361-368].[Z Med Phys 32 (2022) 361-368].

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.006

Gerd Heilemann , Mark Matthewman , Peter Kuess , Gregor Goldner , Joachim Widder , Dietmar Georg , Lukas Zimmermann

引用次数: 0

Erratum to “Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers” [Z Med Phys 32 (2022) 52–62] 基于表面标记光学跟踪的呼吸门控 PBS 质子治疗新方案的调试和质量保证》[Z Med Phys 32 (2022) 52-62] 勘误。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.011

Giovanni Fattori , Jan Hrbacek , Harald Regele , Christian Bula , Alexandre Mayor , Stefan Danuser , David C. Oxley , Urs Rechsteiner , Martin Grossmann , Riccardo Via , Till T. Böhlen , Alessandra Bolsi , Marc Walser , Michele Togno , Emma Colvill , Daniel Lempen , Damien C. Weber , Antony J. Lomax , Sairos Safai

引用次数: 0

Erratum to “Free-breathing half-radial dual-echo balanced steady-state free precession thoracic imaging with wobbling Archimedean spiral pole trajectories” [Z Med. Phys. 33 (2023) 220–229] 自由呼吸半径向双回波平衡稳态自由预处理胸部成像与摆动阿基米德螺旋极轨迹》的勘误[Z Med. Phys. 33 (2023) 220-229]。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.003

Oliver Bieri , Orso Pusterla , Grzegorz Bauman

引用次数: 0

Quo Vadis MRI?

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.12.002

Jürgen Hennig

引用次数: 0

Celebrating 35 Years of Zeitschrift für Medizinische Physik 庆祝医学物理杂志35周年

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2025.01.001

Jürgen R. Reichenbach (Editor-in-Chief)

引用次数: 0

Quo Vadis Hyperpolarized 13C MRI? 超极化 13C 核磁共振成像的现状如何？

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2023.10.004

Pascal Wodtke , Martin Grashei , Franz Schilling

Over the last two decades, hyperpolarized ¹³C MRI has gained significance in both preclinical and clinical studies, hereby relying on technologies like PHIP-SAH (ParaHydrogen-Induced Polarization-Side Arm Hydrogenation), SABRE (Signal Amplification by Reversible Exchange), and dDNP (dissolution Dynamic Nuclear Polarization), with dDNP being applied in humans. A clinical dDNP polarizer has enabled studies across 24 sites, despite challenges like high cost and slow polarization. Parahydrogen-based techniques like SABRE and PHIP offer faster, more cost-efficient alternatives but require molecule-specific optimization. The focus has been on imaging metabolism of hyperpolarized probes, which requires long T₁, high polarization and rapid contrast generation. Efforts to establish novel probes, improve acquisition techniques and enhance data analysis methods including artificial intelligence are ongoing. Potential clinical value of hyperpolarized ¹³C MRI was demonstrated primarily for treatment response assessment in oncology, but also in cardiology, nephrology, hepatology and CNS characterization. In this review on biomedical hyperpolarized ¹³C MRI, we summarize important and recent advances in polarization techniques, probe development, acquisition and analysis methods as well as clinical trials. Starting from those we try to sketch a trajectory where the field of biomedical hyperpolarized ¹³C MRI might go.

在过去的二十年里，超极化 13C MRI 在临床前和临床研究中都获得了重要的地位，这依赖于 PHIP-SAH（副氢诱导极化-侧臂氢化）、SABRE（可逆交换信号放大）和 dDNP（溶解动态核极化）等技术，其中 dDNP 已应用于人体。尽管存在成本高、极化速度慢等挑战，但临床 dDNP 极化器已在 24 个地点开展了研究。SABRE 和 PHIP 等基于对氢的技术提供了更快、更具成本效益的替代方法，但需要针对特定分子进行优化。重点一直放在超极化探针的成像代谢上，这需要长 T1、高极化和快速生成对比度。目前正在努力建立新型探针、改进采集技术和增强数据分析方法（包括人工智能）。超极化 13C 磁共振成像的潜在临床价值主要体现在肿瘤学的治疗反应评估上，同时也体现在心脏病学、肾脏病学、肝脏病学和中枢神经系统特征描述上。在这篇关于生物医学超极化 13C MRI 的综述中，我们总结了极化技术、探针开发、采集和分析方法以及临床试验方面的重要最新进展。从这些进展出发，我们试图勾勒出生物医学超极化 13C MRI 领域的发展轨迹。

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Editorial Board + Consulting Editorial Board 编辑委员会+咨询编辑委员会

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/S0939-3889(25)00014-5

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