Zeitschrift fur Medizinische Physik最新文献

英文中文

Characterization of a new radiochromic film (LD-V1) using mammographic beam qualities 一种新的放射致色膜（LD-V1）的特征利用乳房x线摄影光束质量

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-05-01 DOI: 10.1016/j.zemedi.2023.05.004

Erika Nakajima, Hitoshi Sato

Purpose

Radiochromic film (RCF) is a detector that can obtain a two-dimensional dose distribution with high resolution; it is widely used in medical and industrial fields. Several types of RCFs exist based on their application. The type of RCF mainly used for mammography dose assessment has been discontinued; however, a new type of RCF (LD-V1) has been distributed as a successor. Since the medical use of LD-V1 has rarely been studied, we investigated the response characteristics of LD-V1 in mammography.

Methods

Measurements were performed using Mo/Mo and Rh/Ag on a Senographe Pristina mammography device (GE, Fairfield, CT, USA). The reference air kerma was measured using a parallel-plate ionization chamber (PPIC) (C-MA, Applied Engineering Inc, Tokyo, Japan). Pieces of LD-V1 film model were irradiated at the same position where the reference air kerma in air was measured by the PPIC. Irradiation was performed using the time scale method based on the load on the equipment. Two methods of irradiation were considered: placing the detector in air and on the phantom. The LD-V1 was scanned five times at 72 dpi in RGB (48 bit) mode using a flatbed scanner (ES-G11000, Seiko Epson Corp, Nagano, Japan) 24 h following irradiation. The response ratio of the reference air kerma and the air kerma obtained from the LD-V1 were compared and examined for each beam quality and air kerma range.

Results and discussion

When the beam quality was altered, the response ratio varied from 0.8 to 1.2 with respect to the measurement value of the PPIC; however, some outliers were observed. Response ratios were highly variable in the low-dose range; however, as the air kerma increased, the ratios approached 1. Thus, LD-V1 does not need calibration for each beam quality used in mammography. LD-V1 enables air kerma evaluation by creating air kerma response curves under certain X-ray conditions used in mammography.

Conclusion

We suggest that the dose range be limited to 12 mGy or more to keep the response variation with beam qualities below ±20%. If further measurement is required for reducing the response variation, the dose range should be shifted to a higher dose range.

目的放射致色膜（RCF）是一种能够获得二维高分辨率剂量分布的检测器；广泛应用于医疗和工业领域。根据它们的应用程序，存在几种类型的rcf。主要用于乳房x线摄影剂量评估的RCF类型已停止使用；然而，一种新型的RCF （LD-V1）已被分发作为继任者。由于LD-V1的医学应用很少被研究，我们研究了LD-V1在乳房x光检查中的反应特征。方法在Senographe Pristina乳房x线摄影设备（GE, Fairfield， CT， USA）上使用Mo/Mo和Rh/Ag进行测量。参考空气温度采用平行板电离室（PPIC）测量（C-MA，应用工程公司，东京，日本）。在PPIC测量空气中参考空气浓度的同一位置照射LD-V1膜模型片。辐照采用基于设备负荷的时间尺度法。考虑了两种辐照方法：将探测器放置在空气中和放置在假体上。辐照24小时后，使用平板扫描仪（ES-G11000，精工爱普生公司，日本长野）在RGB（48位）模式下以72 dpi扫描LD-V1 5次。比较了参考空气克尔玛和从LD-V1获得的空气克尔玛的响应比，并检查了每个光束质量和空气克尔玛范围。结果与讨论当光束质量改变时，相对于PPIC测量值的响应比在0.8 ~ 1.2之间变化；然而，也观察到一些异常值。在低剂量范围内，反应率变化很大；然而，随着空气质量的增加，比值接近1。因此，LD-V1不需要对乳房x光检查中使用的每个光束质量进行校准。LD-V1通过在乳房x射线检查中使用的某些x射线条件下创建空气角反应曲线来进行空气角评价。结论建议将辐照剂量控制在12 mGy及以上，使辐照响应随光束质量的变化小于±20%。如果需要进一步测量以减小响应变化，则应将剂量范围转移到更高的剂量范围。

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引用次数: 0

Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system 参考商业处理计划系统，评估粒子处理计划4D （TRiP4D）中的质子和碳离子束模型

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-05-01 DOI: 10.1016/j.zemedi.2023.06.002

Yinxiangzi Sheng , Lennart Volz , Weiwei Wang , Marco Durante , Christian Graeff

Purpose

To investigate the accuracy of the treatment planning system (TPS) TRiP4D in reproducing doses computed by the clinically used TPS SyngoRT.

Methods

Proton and carbon ion beam models in TRiP4D were converted from SyngoRT. Cubic plans with different depths in a water-tank phantom (WP) and previously treated and experimentally verified patient plans from SyngoRT were recalculated in TRiP4D. The target mean dose deviation (ΔD_mean,T) and global gamma index (2%–2 mm for the absorbed dose and 3%–3mm for the RBE-weighted dose with 10% threshold) were evaluated.

Results

The carbon and proton absorbed dose gamma passing rates (γ-PRs) were ≥99.93% and ΔD_mean,T smaller than −0.22%. On average, the RBE-weighted dose D_mean,T was −1.26% lower for TRiP4D than SyngoRT for cubic plans. In TRiP4D, the faster analytical ‘low dose approximation’ (Krämer, 2006) was used, while SyngoRT used a stochastic implementation (Krämer, 2000). The average ΔD_{mean, T} could be reduced to −0.59% when applying the same biological effect calculation algorithm. However, the dose recalculation time increased by a factor of 79–477. ΔD_mean,T variation up to −2.27% and −2.79% was observed for carbon absorbed and RBE-weighted doses in patient plans. The γ-PRs were ≥93.92% and ≥91.83% for patient plans, except for one proton beam with a range shifter (γ-PR of 64.19%).

Conclusion

The absorbed dose between TRiP4D and SyngoRT were identical for both proton and carbon ion plans in the WP. Compared to SyngoRT, TRiP4D underestimated the target RBE-weighted dose; however more efficient in RBE-weighted dose calculation. Large variation for proton beam with range shifter was observed. TRiP4D will be used to evaluate doses delivered to moving targets. Uncertainties inherent to the 4D-dose reconstruction calculation are expected to be significantly larger than the dose errors reported here. For this reason, the residual differences between TRiP4D and SyngoRT observed in this study are considered acceptable.

The study was approved by the Institutional Research Board of Shanghai Proton and Heavy Ion Center (approval number SPHIC-MP-2020-04, RS).

目的探讨治疗计划系统（TPS） TRiP4D复制临床使用的TPS SyngoRT计算剂量的准确性。方法将质子和碳离子束模型从SyngoRT转换为TRiP4D。在TRiP4D中重新计算水箱幻影（WP）中不同深度的立方平面图和先前经过SyngoRT治疗和实验验证的患者平面图。评估了目标平均剂量偏差（ΔDmean，T）和总体伽马指数（吸收剂量为2%-2 mm， 10%阈值的rbe加权剂量为3%-3mm）。结果碳、质子吸收剂量γ通过率(γ- pr)≥99.93%,γ- pr≥ΔDmean,T < - 0.22%。在立方方案中，TRiP4D的rbe加权剂量Dmean，T平均比SyngoRT低- 1.26%。在TRiP4D中，使用了更快的分析“低剂量近似”（Krämer, 2006），而SyngoRT使用了随机实现（Krämer, 2000）。采用相同的生物效应计算算法，平均ΔDmean， T可降至−0.59%。然而，剂量重新计算时间增加了79-477倍。ΔDmean，在患者计划中，碳吸收剂量和rbe加权剂量的T变化高达- 2.27%和- 2.79%。患者计划γ-PR≥93.92%和≥91.83%，除了一个质子束带范围移位器（γ-PR为64.19%）。结论TRiP4D和SyngoRT在质子和碳离子计划下的吸收剂量相同。与SyngoRT相比，TRiP4D低估了靶rbe加权剂量；但在rbe加权剂量计算中更有效。用移程器对质子束进行了较大的变化。TRiP4D将用于评估运送到移动目标的剂量。4d剂量重建计算固有的不确定性预计将明显大于本文报道的剂量误差。因此，本研究中观察到的TRiP4D与SyngoRT的残留差异是可以接受的。本研究已获上海市质子重离子中心机构研究委员会批准（批准文号SPHIC-MP-2020-04， RS）。

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引用次数: 0

Rapid whole-brain quantitative MT imaging 快速全脑定量MT成像

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2023.02.005

Roya Afshari , Francesco Santini , Rahel Heule , Craig H. Meyer , Josef Pfeuffer , Oliver Bieri

Purpose

To provide a robust whole-brain quantitative magnetization transfer (MT) imaging method that is not limited by long acquisition times.

Methods

Two variants of a spiral 2D interleaved multi-slice spoiled gradient echo (SPGR) sequence are used for rapid quantitative MT imaging of the brain at 3 T. A dual flip angle, steady-state prepared, double-contrast method is used for combined B₁ and-T₁ mapping in combination with a single-contrast MT-prepared acquisition over a range of different saturation flip angles (50 deg to 850 deg) and offset frequencies (1 kHz and 10 kHz). Five sets (containing minimum 6 to maximum 18 scans) with different MT-weightings were acquired. In addition, main magnetic field inhomogeneities (ΔB₀) were measured from two Cartesian low-resolution 2D SPGR scans with different echo times. Quantitative MT model parameters were derived from all sets using a two-pool continuous-wave model analysis, yielding the pool-size ratio, F, their exchange rate, k_f, and their transverse relaxation time, T_2r.

Results

Whole-brain quantitative MT imaging was feasible for all sets with total acquisition times ranging from 7:15 min down to 3:15 min. For accurate modeling, B₁-correction was essential for all investigated sets, whereas ΔB₀-correction showed limited bias for the observed maximum off-resonances at 3 T.

Conclusion

The combination of rapid B₁-T₁ mapping and MT-weighted imaging using a 2D multi-slice spiral SPGR research sequence offers excellent prospects for rapid whole-brain quantitative MT imaging in the clinical setting.

目的提供一种不受采集时间限制的全脑定量磁化转移成像方法。方法采用两种不同的螺旋二维交错多层破坏梯度回波（SPGR）序列，在3 t时对大脑进行快速定量MT成像。采用双翻转角度、稳态制备的双对比度方法，在不同的饱和翻转角度（50°至850°）和偏移频率（1 kHz和10 kHz）范围内，结合单对比度MT制备的采集，进行B1和t1的组合成像。获得了5组不同mt权重的扫描（包含最少6到最多18次扫描）。此外，通过两次不同回波时间的笛卡尔低分辨率二维SPGR扫描测量了主磁场不均匀性（ΔB0）。使用双池连续波模型分析从所有集合中获得定量MT模型参数，得到池大小比F、它们的汇率kf和它们的横向弛豫时间T2r。结果全脑定量MT成像对所有集都是可行的，总采集时间从7:15 min到3:15 min不等。为了准确建模，b1校正对所有研究集都是必不可少的。结论快速B1-T1定位与二维多层螺旋SPGR研究序列的MT加权成像相结合，为临床快速全脑定量MT成像提供了良好的前景。

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引用次数: 0

Erratum to “The role of Monte Carlo simulation in understanding the performance of proton computed tomography” [Z Med Phys 32 (2022) 23–38] 对 "蒙特卡罗模拟在了解质子计算机断层扫描性能方面的作用 "的勘误 [Z Med Phys 32 (2022) 23-38]。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.012

George Dedes , Jannis Dickmann , Valentina Giacometti , Simon Rit , Nils Krah , Sebastian Meyer , Vladimir Bashkirov , Reinhard Schulte , Robert P. Johnson , Katia Parodi , Guillaume Landry

引用次数: 0

Erratum to “Volumetric 23Na single and triple-quantum imaging at 7T: 3D-CRISTINA” [Z Med Phys 32 (2022) 199–208] 对 "7T 下的容积 23Na 单量子和三量子成像：3D-CRISTINA "的勘误 [Z Med Phys 32 (2022) 199-208]。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.008

Michaela A.U. Hoesl , Lothar R. Schad , Stanislas Rapacchi

引用次数: 0

Non-contrast free-breathing liver perfusion imaging using velocity selective ASL combined with prospective motion compensation 利用速度选择性 ASL 结合前瞻性运动补偿进行非对比自由呼吸肝脏灌注成像。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.06.001

Ke Zhang , Simon M.F. Triphan , Mark O. Wielpütz , Christian H. Ziener , Mark E. Ladd , Heinz-Peter Schlemmer , Hans-Ulrich Kauczor , Oliver Sedlaczek , Felix T. Kurz

Purpose

To apply velocity selective arterial spin labeling (VSASL) combined with a navigator-based (NAV) prospective motion compensation method for a free–breathing liver perfusion measurement without contrast agent.

Methods

Sinc-modulated Velocity Selective Inversion (sinc-VSI) pulses were applied as labeling and control pulses. In order to account for respiratory motion, a navigator was employed in the form of a single gradient-echo projection readout, located at the diaphragm along the inferior-superior direction. Prior to each transverse imaging slice of the spin-echo EPI based readouts, navigator and fat suppression were incorporated. Motion data was obtained from the navigator and transmitted back to the sequence, allowing real-time adjustments to slice positioning. The sinc-VSI without velocity-selective gradients during the control condition but with velocity-selective gradients along all three directions during labeling was chosen for the VSASL. The VSASL was compared with pseudo-continuous ASL (pCASL) methods, which selectively tagged the moving spins using a tagging plane placed at the portal vein and hepatic artery.

Results

The motion caused by respiratory activity was effectively computed using the navigator signal. The coefficients of variation (CoV) of average liver voxel in NAV were significantly decreased when compared to breath-hold (BH), with an average reduction of 29.4 ± 18.44% for control images, and 29.89 ± 20.83% for label images (p < 0.001). The resulting maps of normalized ASL signal (normalized to M₀) showed significantly higher perfusion weightings in the NAV-compensated VSASL, when compared to the NAV-compensated pCASL techniques.

Conclusions

This study demonstrates the feasibility of using a navigator-based prospective motion compensation technique in conjunction with VSASL for the measurement of liver perfusion without the use of contrast agents while allowing for free-breathing.

目的：将速度选择性动脉自旋标记（VSASL）与基于导航仪的前瞻性运动补偿方法相结合，用于不使用造影剂的自由呼吸肝脏灌注测量：方法：采用锌调制速度选择性反转（sinc-VSI）脉冲作为标记和控制脉冲。为了考虑呼吸运动，采用了一个导航仪，其形式为单个梯度回波投影读数，位于膈肌沿下-上方向。在基于自旋回波 EPI 的读数的每个横向成像切片之前，都加入了导航仪和脂肪抑制。从导航仪获取运动数据并传回序列，以便实时调整切片定位。VSASL 采用的 sinc-VSI 在控制条件下没有速度选择梯度，但在标记时沿所有三个方向都有速度选择梯度。VSASL 与伪连续 ASL（pseudo-continuous ASL，pCASL）方法进行了比较，后者是通过放置在门静脉和肝动脉处的标记平面选择性标记移动的自旋：结果：利用导航信号可有效计算呼吸活动引起的运动。与屏气（BH）相比，NAV中平均肝脏体素的变异系数（CoV）明显降低，对照图像平均降低29.4±18.44%，标签图像平均降低29.89±20.83%（P 0），与NAV补偿的pCASL技术相比，NAV补偿的VSASL显示出明显更高的灌注权重：这项研究证明了将基于导航仪的前瞻性运动补偿技术与 VSASL 结合使用，在不使用造影剂、允许自由呼吸的情况下测量肝脏灌注的可行性。

{"title":"Non-contrast free-breathing liver perfusion imaging using velocity selective ASL combined with prospective motion compensation","authors":"Ke Zhang , Simon M.F. Triphan , Mark O. Wielpütz , Christian H. Ziener , Mark E. Ladd , Heinz-Peter Schlemmer , Hans-Ulrich Kauczor , Oliver Sedlaczek , Felix T. Kurz","doi":"10.1016/j.zemedi.2024.06.001","DOIUrl":"10.1016/j.zemedi.2024.06.001","url":null,"abstract":"<div><h3>Purpose</h3><div>To apply velocity selective arterial spin labeling (VSASL) combined with a navigator-based (NAV) prospective motion compensation method for a free–breathing liver perfusion measurement without contrast agent.</div></div><div><h3>Methods</h3><div>Sinc-modulated Velocity Selective Inversion (sinc-VSI) pulses were applied as labeling and control pulses. In order to account for respiratory motion, a navigator was employed in the form of a single gradient-echo projection readout, located at the diaphragm along the inferior-superior direction. Prior to each transverse imaging slice of the spin-echo EPI based readouts, navigator and fat suppression were incorporated. Motion data was obtained from the navigator and transmitted back to the sequence, allowing real-time adjustments to slice positioning. The sinc-VSI without velocity-selective gradients during the control condition but with velocity-selective gradients along all three directions during labeling was chosen for the VSASL. The VSASL was compared with pseudo-continuous ASL (pCASL) methods, which selectively tagged the moving spins using a tagging plane placed at the portal vein and hepatic artery.</div></div><div><h3>Results</h3><div>The motion caused by respiratory activity was effectively computed using the navigator signal. The coefficients of variation (CoV) of average liver voxel in NAV were significantly decreased when compared to breath-hold (BH), with an average reduction of 29.4 ± 18.44% for control images, and 29.89 ± 20.83% for label images (p < 0.001). The resulting maps of normalized ASL signal (normalized to M<sub>0</sub>) showed significantly higher perfusion weightings in the NAV-compensated VSASL, when compared to the NAV-compensated pCASL techniques.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the feasibility of using a navigator-based prospective motion compensation technique in conjunction with VSASL for the measurement of liver perfusion without the use of contrast agents while allowing for free-breathing.</div></div>","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 87-97"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “Can Generative Adversarial Networks help to overcome the limited data problem in segmentation?” [Z Med Phys 32 (2022) 361–368] 对 "生成式对抗网络能否帮助克服分割中的数据有限问题？"的勘误 [Z Med Phys 32 (2022) 361-368].[Z Med Phys 32 (2022) 361-368].

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.006

Gerd Heilemann , Mark Matthewman , Peter Kuess , Gregor Goldner , Joachim Widder , Dietmar Georg , Lukas Zimmermann

引用次数: 0

Erratum to “Commissioning and quality assurance of a novel solution for respiratory-gated PBS proton therapy based on optical tracking of surface markers” [Z Med Phys 32 (2022) 52–62] 基于表面标记光学跟踪的呼吸门控 PBS 质子治疗新方案的调试和质量保证》[Z Med Phys 32 (2022) 52-62] 勘误。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.011

Giovanni Fattori , Jan Hrbacek , Harald Regele , Christian Bula , Alexandre Mayor , Stefan Danuser , David C. Oxley , Urs Rechsteiner , Martin Grossmann , Riccardo Via , Till T. Böhlen , Alessandra Bolsi , Marc Walser , Michele Togno , Emma Colvill , Daniel Lempen , Damien C. Weber , Antony J. Lomax , Sairos Safai

引用次数: 0

Erratum to “Free-breathing half-radial dual-echo balanced steady-state free precession thoracic imaging with wobbling Archimedean spiral pole trajectories” [Z Med. Phys. 33 (2023) 220–229] 自由呼吸半径向双回波平衡稳态自由预处理胸部成像与摆动阿基米德螺旋极轨迹》的勘误[Z Med. Phys. 33 (2023) 220-229]。

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.07.003

Oliver Bieri , Orso Pusterla , Grzegorz Bauman

引用次数: 0

Quo Vadis MRI?

IF 2.4 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Zeitschrift fur Medizinische Physik

Pub Date : 2025-02-01 DOI: 10.1016/j.zemedi.2024.12.002

Jürgen Hennig

引用次数: 0

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