Pub Date : 2025-02-01DOI: 10.1016/j.zemedi.2025.01.001
Jürgen R. Reichenbach (Editor-in-Chief)
{"title":"Celebrating 35 Years of Zeitschrift für Medizinische Physik","authors":"Jürgen R. Reichenbach (Editor-in-Chief)","doi":"10.1016/j.zemedi.2025.01.001","DOIUrl":"10.1016/j.zemedi.2025.01.001","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 1-2"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.zemedi.2023.10.004
Pascal Wodtke , Martin Grashei , Franz Schilling
Over the last two decades, hyperpolarized 13C MRI has gained significance in both preclinical and clinical studies, hereby relying on technologies like PHIP-SAH (ParaHydrogen-Induced Polarization-Side Arm Hydrogenation), SABRE (Signal Amplification by Reversible Exchange), and dDNP (dissolution Dynamic Nuclear Polarization), with dDNP being applied in humans. A clinical dDNP polarizer has enabled studies across 24 sites, despite challenges like high cost and slow polarization. Parahydrogen-based techniques like SABRE and PHIP offer faster, more cost-efficient alternatives but require molecule-specific optimization. The focus has been on imaging metabolism of hyperpolarized probes, which requires long T1, high polarization and rapid contrast generation. Efforts to establish novel probes, improve acquisition techniques and enhance data analysis methods including artificial intelligence are ongoing. Potential clinical value of hyperpolarized 13C MRI was demonstrated primarily for treatment response assessment in oncology, but also in cardiology, nephrology, hepatology and CNS characterization. In this review on biomedical hyperpolarized 13C MRI, we summarize important and recent advances in polarization techniques, probe development, acquisition and analysis methods as well as clinical trials. Starting from those we try to sketch a trajectory where the field of biomedical hyperpolarized 13C MRI might go.
{"title":"Quo Vadis Hyperpolarized 13C MRI?","authors":"Pascal Wodtke , Martin Grashei , Franz Schilling","doi":"10.1016/j.zemedi.2023.10.004","DOIUrl":"10.1016/j.zemedi.2023.10.004","url":null,"abstract":"<div><div>Over the last two decades, hyperpolarized <sup>13</sup>C MRI has gained significance in both preclinical and clinical studies, hereby relying on technologies like PHIP-SAH (ParaHydrogen-Induced Polarization-Side Arm Hydrogenation), SABRE (Signal Amplification by Reversible Exchange), and dDNP (dissolution Dynamic Nuclear Polarization), with dDNP being applied in humans. A clinical dDNP polarizer has enabled studies across 24 sites, despite challenges like high cost and slow polarization. Parahydrogen-based techniques like SABRE and PHIP offer faster, more cost-efficient alternatives but require molecule-specific optimization. The focus has been on imaging metabolism of hyperpolarized probes, which requires long <em>T<sub>1</sub></em>, high polarization and rapid contrast generation. Efforts to establish novel probes, improve acquisition techniques and enhance data analysis methods including artificial intelligence are ongoing. Potential clinical value of hyperpolarized <sup>13</sup>C MRI was demonstrated primarily for treatment response assessment in oncology, but also in cardiology, nephrology, hepatology and CNS characterization. In this review on biomedical hyperpolarized <sup>13</sup>C MRI, we summarize important and recent advances in polarization techniques, probe development, acquisition and analysis methods as well as clinical trials. Starting from those we try to sketch a trajectory where the field of biomedical hyperpolarized <sup>13</sup>C MRI might go.</div></div>","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 8-32"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139068000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.zemedi.2024.07.002
Lukas Nierer , Florian Kamp , Michael Reiner , Stefanie Corradini , Moritz Rabe , Olaf Dietrich , Katia Parodi , Claus Belka , Christopher Kurz , Guillaume Landry
{"title":"Erratum to “Evaluation of an anthropomorphic ion chamber and 3D gel dosimetry head phantom at a 0.35 T MR-linac using separate 1.5 T MR-scanners for gel readout” [Z Med. Phys. 32 (2022) 312–325]","authors":"Lukas Nierer , Florian Kamp , Michael Reiner , Stefanie Corradini , Moritz Rabe , Olaf Dietrich , Katia Parodi , Claus Belka , Christopher Kurz , Guillaume Landry","doi":"10.1016/j.zemedi.2024.07.002","DOIUrl":"10.1016/j.zemedi.2024.07.002","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Page 118"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.zemedi.2024.07.005
Nicholas M. Brisson , Martin Krämer , Leonie A.N. Krahl , Alexander Schill , Georg N. Duda , Jürgen R. Reichenbach
{"title":"Erratum to “A novel multipurpose device for guided knee motion and loading during dynamic magnetic resonance imaging” [Z Med Phys 32 (2022) 500–513]","authors":"Nicholas M. Brisson , Martin Krämer , Leonie A.N. Krahl , Alexander Schill , Georg N. Duda , Jürgen R. Reichenbach","doi":"10.1016/j.zemedi.2024.07.005","DOIUrl":"10.1016/j.zemedi.2024.07.005","url":null,"abstract":"","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Page 116"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.zemedi.2024.12.004
Christian Licht , Efe Ilicak , Fernando E. Boada , Maxime Guye , Frank G. Zöllner , Lothar R. Schad , Stanislas Rapacchi
Purpose
To develop an improved post-processing pipeline for noise-robust accelerated phase-cycled Cartesian Single (SQ) and Triple Quantum (TQ) sodium (23Na) Magnetic Resonance Imaging (MRI) of in vivo human brain at 7 T.
Theory and Methods
Our pipeline aims to tackle the challenges of 23Na Multi-Quantum Coherences (MQC) MRI including low Signal-to-Noise Ratio (SNR) and time-consuming Radiofrequency (RF) phase-cycling. Our method combines low-rank k-space denoising for SNR enhancement with Dynamic Mode Decomposition (DMD) to robustly separate SQ and TQ signal components. This separation is crucial for computing the TQ/SQ ratio, a key parameter of 23Na MQC MRI. We validated our pipeline in silico, in vitro and in vivo in healthy volunteers, comparing it with conventional denoising and Fourier transform (FT) methods. Additionally, we assessed its robustness through ablation experiments simulating a corrupted RF phase-cycle step.
Results
Our denoising algorithm doubled SNR compared to non-denoised images and enhanced SNR by up to 29% compared to Wavelet denoising. The low-rank approach produced high-quality images even at later echo times, allowing reduced signal averaging. DMD effectively separated the SQ and TQ signals, even with missing RF phase cycle steps, resulting in superior Structural Similarity (SSIM) of and lower Root Mean Squared Error (RMSE) of compared to conventional FT methods (SSIM=, RMSE=). This pipeline enabled high-quality 8x8x15mm3 in vivo 23Na MQC MRI, with a reduction in acquisition time from 48 to 10 min at 7 T.
Conclusion
The proposed pipeline improves robustness in 23Na MQC MRI by exploiting low-rank properties to denoise signals and DMD to effectively separate SQ and TQ signals. This approach ensures high-quality MR images of both SQ and TQ components, even in accelerated and incomplete RF phase-cycling cases.
{"title":"A noise-robust post-processing pipeline for accelerated phase-cycled 23Na Multi-Quantum Coherences MRI","authors":"Christian Licht , Efe Ilicak , Fernando E. Boada , Maxime Guye , Frank G. Zöllner , Lothar R. Schad , Stanislas Rapacchi","doi":"10.1016/j.zemedi.2024.12.004","DOIUrl":"10.1016/j.zemedi.2024.12.004","url":null,"abstract":"<div><h3><strong>Purpose</strong></h3><div>To develop an improved post-processing pipeline for noise-robust accelerated phase-cycled Cartesian Single (SQ) and Triple Quantum (TQ) sodium (<sup>23</sup>Na) Magnetic Resonance Imaging (MRI) of in vivo human brain at 7 T.</div></div><div><h3><strong>Theory and Methods</strong></h3><div>Our pipeline aims to tackle the challenges of <sup>23</sup>Na Multi-Quantum Coherences (MQC) MRI including low Signal-to-Noise Ratio (SNR) and time-consuming Radiofrequency (RF) phase-cycling. Our method combines low-rank k-space denoising for SNR enhancement with Dynamic Mode Decomposition (DMD) to robustly separate SQ and TQ signal components. This separation is crucial for computing the TQ/SQ ratio, a key parameter of <sup>23</sup>Na MQC MRI. We validated our pipeline in silico, in vitro and in vivo in healthy volunteers, comparing it with conventional denoising and Fourier transform (FT) methods. Additionally, we assessed its robustness through ablation experiments simulating a corrupted RF phase-cycle step.</div></div><div><h3><strong>Results</strong></h3><div>Our denoising algorithm doubled SNR compared to non-denoised images and enhanced SNR by up to 29% compared to Wavelet denoising. The low-rank approach produced high-quality images even at later echo times, allowing reduced signal averaging. DMD effectively separated the SQ and TQ signals, even with missing RF phase cycle steps, resulting in superior Structural Similarity (SSIM) of <span><math><mrow><mn>0.89</mn><mo>±</mo><mn>0.024</mn></mrow></math></span> and lower Root Mean Squared Error (RMSE) of <span><math><mrow><mn>0.055</mn><mo>±</mo><mn>0.008</mn></mrow></math></span> compared to conventional FT methods (SSIM=<span><math><mrow><mn>0.71</mn><mo>±</mo><mn>0.061</mn></mrow></math></span>, RMSE=<span><math><mrow><mn>0.144</mn><mo>±</mo><mn>0.036</mn></mrow></math></span>). This pipeline enabled high-quality 8x8x15mm<sup>3</sup> in vivo <sup>23</sup>Na MQC MRI, with a reduction in acquisition time from 48 to 10 min at 7 T.</div></div><div><h3><strong>Conclusion</strong></h3><div>The proposed pipeline improves robustness in <sup>23</sup>Na MQC MRI by exploiting low-rank properties to denoise signals and DMD to effectively separate SQ and TQ signals. This approach ensures high-quality MR images of both SQ and TQ components, even in accelerated and incomplete RF phase-cycling cases.</div></div>","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 98-108"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.zemedi.2023.08.005
Agilo Luitger Kern , Marcel Gutberlet , Regina Rumpel , Inga Bruesch , Jens M. Hohlfeld , Frank Wacker , Bennet Hensen
129Xe hyperpolarized gas chemical exchange saturation transfer (HyperCEST) MRI has been suggested as molecular imaging modality but translation to in vivo imaging has been slow, likely due to difficulties of synthesizing suitable molecules. Cucurbit[6]uril–either in readily available non-functionalized or potentially in functionalized form–may, combined with 129Xe HyperCEST MRI, prove useful as a switchable 129Xe MR contrast agent but the likely differential properties of contrast generation in individual chemical compartments as well as the influence of 129Xe signal drifts encountered in vivo on HyperCEST MRI are unknown. Here, HyperCEST z spectroscopy and chemical shift imaging with compartment-specific analysis are performed in a total of 10 rats using cucurbit[6]uril injected i.v. and under a protocol employing spontaneous respiration. Differences in intensity of the HyperCEST effect between chemical compartments and anatomical regions are investigated. Strategies to mitigate influence of signal instabilities associated with drifts in physiological parameters are developed. It is shown that presence of cucurbit[6]uril can be readily detected under spontaneous 129Xe inhalation mostly in aqueous tissues further away from the lung. Differences of effect intensity in individual regions and compartments must be considered in HyperCEST data interpretation. In particular, there seems to be almost no effect in lipids. 129Xe HyperCEST MR measurements utilizing spontaneous respiration protocols and extended measurement times are feasible. HyperCEST MRI of non-functionalized cucurbit[6]uril may create contrast between anatomical structures in vivo.
{"title":"Compartment-specific 129Xe HyperCEST z spectroscopy and chemical shift imaging of cucurbit[6]uril in spontaneously breathing rats","authors":"Agilo Luitger Kern , Marcel Gutberlet , Regina Rumpel , Inga Bruesch , Jens M. Hohlfeld , Frank Wacker , Bennet Hensen","doi":"10.1016/j.zemedi.2023.08.005","DOIUrl":"10.1016/j.zemedi.2023.08.005","url":null,"abstract":"<div><div><sup>129</sup>Xe hyperpolarized gas chemical exchange saturation transfer (HyperCEST) MRI has been suggested as molecular imaging modality but translation to in vivo imaging has been slow, likely due to difficulties of synthesizing suitable molecules. Cucurbit[6]uril–either in readily available non-functionalized or potentially in functionalized form–may, combined with <sup>129</sup>Xe HyperCEST MRI, prove useful as a switchable <sup>129</sup>Xe MR contrast agent but the likely differential properties of contrast generation in individual chemical compartments as well as the influence of <sup>129</sup>Xe signal drifts encountered in vivo on HyperCEST MRI are unknown. Here, HyperCEST z spectroscopy and chemical shift imaging with compartment-specific analysis are performed in a total of 10 rats using cucurbit[6]uril injected i.v. and under a protocol employing spontaneous respiration. Differences in intensity of the HyperCEST effect between chemical compartments and anatomical regions are investigated. Strategies to mitigate influence of signal instabilities associated with drifts in physiological parameters are developed. It is shown that presence of cucurbit[6]uril can be readily detected under spontaneous <sup>129</sup>Xe inhalation mostly in aqueous tissues further away from the lung. Differences of effect intensity in individual regions and compartments must be considered in HyperCEST data interpretation. In particular, there seems to be almost no effect in lipids. <sup>129</sup>Xe HyperCEST MR measurements utilizing spontaneous respiration protocols and extended measurement times are feasible. HyperCEST MRI of non-functionalized cucurbit[6]uril may create contrast between anatomical structures in vivo.</div></div>","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 33-45"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10136802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.zemedi.2024.07.004
Simon Schröer , Daniel Düx , Josef Joaquin Löning Caballero , Julian Glandorf , Thomas Gerlach , Dominik Horstmann , Othmar Belker , Moritz Gutt , Frank Wacker , Oliver Speck , Bennet Hensen , Marcel Gutberlet
Magnetic Resonance (MR) thermometry is used for the monitoring of MR-guided microwave ablations (MWA), and for the intraoperative evaluation of ablation regions. Nevertheless, the accuracy of temperature mapping may be compromised by electromagnetic interference emanating from the microwave (MW) generator. This study evaluated different setups for improving magnetic resonance imaging (MRI) during MWA with a modified MW generator.
MWA was performed in 15 gel phantoms comparing three setups: The MW generator was placed outside the MR scanner room, either connected to the MW applicator using a penetration panel with a radiofrequency (RF) filter and a 7 m coaxial cable (Setup 1), or through a waveguide using a 5 m coaxial cable (Setup 2). Setup 3 employed the MW generator within the MR scan room, connected by a 5 m coaxial cable. The coaxial cables in setups 2 and 3 were modified with custom shielding to reduce interference. The setups during ablation (active setup) were compared to a reference setup without the presence of the MW system. Thermometry and thermal dose maps (CEM43 model) were compared for the three configurations. Primary endpoints for assessment were signal-to-noise ratio (SNR), temperature precision, Sørensen-Dice-Coefficient (DSC), and RF-noise spectra.
Setup 3 showed highly significant electromagnetic interference during ablation with a SNR decrease by −60.4%±13.5% () compared to reference imaging. For setup 1 and setup 2 no significant decrease in SNR was measured with differences of −2.9%±9.8% () and −1.5%±12.8% (), respectively. SNR differences were significant between active setups 1 and 3 with −51.2%±16.1% () and between active setups 2 and 3 with −59.0%±15.5% () but not significant between active setups 1 and 2 with 19.0%±13.7% (). Furthermore, no significant differences were seen in temperature precision or DSCs between all setups, ranging from 0.33 °C ± 0.04 °C (Setup 1) to 0.38 °C ± 0.06 °C (Setup 3) () and from 87.0%±1.6% (Setup 3) to 88.1%±1.6% (Setup 2) (), respectively.
Both setups (1 and 2) with the MW generator outside the MR scanner room were beneficial to reduce electromagnetic interference during MWA. Moreover, provided that a shielded cable is utilized in setups 2 and 3, all configurations displayed negligible differences in temperature precision and DSCs, indicating that the location of the MW gener
{"title":"Reducing electromagnetic interference in MR thermometry: A comparison of setup configurations for MR-guided microwave ablations","authors":"Simon Schröer , Daniel Düx , Josef Joaquin Löning Caballero , Julian Glandorf , Thomas Gerlach , Dominik Horstmann , Othmar Belker , Moritz Gutt , Frank Wacker , Oliver Speck , Bennet Hensen , Marcel Gutberlet","doi":"10.1016/j.zemedi.2024.07.004","DOIUrl":"10.1016/j.zemedi.2024.07.004","url":null,"abstract":"<div><div>Magnetic Resonance (MR) thermometry is used for the monitoring of MR-guided microwave ablations (MWA), and for the intraoperative evaluation of ablation regions. Nevertheless, the accuracy of temperature mapping may be compromised by electromagnetic interference emanating from the microwave (MW) generator. This study evaluated different setups for improving magnetic resonance imaging (MRI) during MWA with a modified MW generator.</div><div>MWA was performed in 15 gel phantoms comparing three setups: The MW generator was placed outside the MR scanner room, either connected to the MW applicator using a penetration panel with a radiofrequency (RF) filter and a 7 m coaxial cable (Setup 1), or through a waveguide using a 5 m coaxial cable (Setup 2). Setup 3 employed the MW generator within the MR scan room, connected by a 5 m coaxial cable. The coaxial cables in setups 2 and 3 were modified with custom shielding to reduce interference. The setups during ablation (active setup) were compared to a reference setup without the presence of the MW system. Thermometry and thermal dose maps (CEM43 model) were compared for the three configurations. Primary endpoints for assessment were signal-to-noise ratio (SNR), temperature precision, Sørensen-Dice-Coefficient (DSC), and RF-noise spectra.</div><div>Setup 3 showed highly significant electromagnetic interference during ablation with a SNR decrease by −60.4%±13.5% (<span><math><mrow><mi>p</mi><mo><</mo><mn>0.001</mn></mrow></math></span>) compared to reference imaging. For setup 1 and setup 2 no significant decrease in SNR was measured with differences of −2.9%±9.8% (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.6</mn></mrow></math></span>) and −1.5%±12.8% (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.8</mn></mrow></math></span>), respectively. SNR differences were significant between active setups 1 and 3 with −51.2%±16.1% (<span><math><mrow><mi>p</mi><mo><</mo><mn>0.001</mn></mrow></math></span>) and between active setups 2 and 3 with −59.0%±15.5% (<span><math><mrow><mi>p</mi><mo><</mo><mn>0.001</mn></mrow></math></span>) but not significant between active setups 1 and 2 with 19.0%±13.7% (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.09</mn></mrow></math></span>). Furthermore, no significant differences were seen in temperature precision or DSCs between all setups, ranging from 0.33 °C ± 0.04 °C (Setup 1) to 0.38 °C ± 0.06 °C (Setup 3) (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.6</mn></mrow></math></span>) and from 87.0%±1.6% (Setup 3) to 88.1%±1.6% (Setup 2) (<span><math><mrow><mi>p</mi><mo>=</mo><mn>0.58</mn></mrow></math></span>), respectively.</div><div>Both setups (1 and 2) with the MW generator outside the MR scanner room were beneficial to reduce electromagnetic interference during MWA. Moreover, provided that a shielded cable is utilized in setups 2 and 3, all configurations displayed negligible differences in temperature precision and DSCs, indicating that the location of the MW gener","PeriodicalId":54397,"journal":{"name":"Zeitschrift fur Medizinische Physik","volume":"35 1","pages":"Pages 59-68"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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