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Interpenetrating polymer network hydrogels as bioactive scaffolds for tissue engineering. 互穿聚合物网络水凝胶作为组织工程生物活性支架
IF 4.9 3区 工程技术 Q1 ENGINEERING, CHEMICAL Pub Date : 2022-04-26 Epub Date: 2020-09-14 DOI: 10.1515/revce-2020-0039
Cody O Crosby, Brett Stern, Nikhith Kalkunte, Shahar Pedahzur, Shreya Ramesh, Janet Zoldan

Tissue engineering, after decades of exciting progress and monumental breakthroughs, has yet to make a significant impact on patient health. It has become apparent that a dearth of biomaterial scaffolds that possess the material properties of human tissue while remaining bioactive and cytocompatible has been partly responsible for this lack of clinical translation. Herein, we propose the development of interpenetrating polymer network hydrogels as materials that can provide cells with an adhesive extracellular matrix-like 3D microenvironment while possessing the mechanical integrity to withstand physiological forces. These hydrogels can be synthesized from biologically-derived or synthetic polymers, the former polymer offering preservation of adhesion, degradability, and microstructure and the latter polymer offering tunability and superior mechanical properties. We review critical advances in the enhancement of mechanical strength, substrate-scale stiffness, electrical conductivity, and degradation in IPN hydrogels intended as bioactive scaffolds in the past five years. We also highlight the exciting incorporation of IPN hydrogels into state-of-the-art tissue engineering technologies, such as organ-on-a-chip and bioprinting platforms. These materials will be critical in the engineering of functional tissue for transplant, disease modeling, and drug screening.

摘要组织工程经过几十年令人兴奋的进展和重大突破,尚未对患者健康产生重大影响。很明显,缺乏具有人体组织材料特性同时保持生物活性和细胞相容性的生物材料支架,是缺乏临床转化的部分原因。在此,我们提出开发互穿聚合物网络(IPN)水凝胶作为材料,该材料可以为细胞提供粘附的细胞外基质样3D微环境,同时具有承受生理力的机械完整性。这些水凝胶可以由生物衍生或合成的聚合物合成,前者提供粘附性、可降解性和微观结构的保护,而后者提供可调谐性和优异的机械性能。我们回顾了在过去5年中,作为生物活性支架的IPN水凝胶在增强机械强度、基底尺度刚度、导电性和降解方面的关键进展。我们还强调了IPN水凝胶令人兴奋地融入最先进的组织工程技术,如芯片上的组织和生物打印平台。这些材料将在移植、疾病建模和药物筛选的功能组织工程中发挥关键作用。
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引用次数: 0
A comprehensive review of the application of DEM in the investigation of batch solid mixers 数值模拟在间歇式固体混合器研究中的应用综述
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-03-28 DOI: 10.1515/revce-2021-0049
B. Jadidi, M. Ebrahimi, F. Ein‐Mozaffari, A. Lohi
Abstract Powder mixing is a vital operation in a wide range of industries, such as food, pharmaceutical, and cosmetics. Despite the common use of mixing systems in various industries, often due to the complex nature of mixing systems, the effects of operating and design parameters on the mixers’ performance and final blend are not fully known, and therefore optimal parameters are selected through experience or trial and error. Experimental and numerical techniques have been widely used to analyze mixing systems and to gain a detailed understanding of mixing processes. The limitations associated with experimental techniques, however, have made discrete element method (DEM) a valuable complementary tool to obtain comprehensive particle level information about mixing systems. In the present study, the fundamentals of solid-solid mixing, segregation, and characteristics of different types of batch solid mixers are briefly reviewed. Previously published papers related to the application of DEM in studying mixing quality and assessing the influence of operating and design parameters on the mixing performance of various batch mixing systems are summarized in detail. The challenges with regards to the DEM simulation of mixing systems, the available solutions to address those challenges and our recommendations for future simulations of solid mixing are also presented and discussed.
摘要粉末混合在食品、制药和化妆品等众多行业中都是至关重要的操作。尽管混合系统在各个行业中普遍使用,但通常由于混合系统的复杂性,操作和设计参数对混合器性能和最终混合物的影响尚不完全清楚,因此通过经验或试错来选择最佳参数。实验和数值技术已被广泛用于分析混合系统并获得对混合过程的详细理解。然而,与实验技术相关的局限性使离散单元法(DEM)成为一种有价值的补充工具,可以获得有关混合系统的全面颗粒水平信息。在本研究中,简要回顾了固体-固体混合的基本原理、分离以及不同类型的间歇式固体混合器的特性。详细总结了先前发表的有关DEM在研究混合质量以及评估操作和设计参数对各种分批混合系统混合性能的影响方面的应用的论文。还介绍和讨论了混合系统DEM模拟方面的挑战、解决这些挑战的可用解决方案以及我们对未来固体混合模拟的建议。
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引用次数: 10
Review of applications of electrical resistance tomography to chemical engineering 电阻层析成像技术在化工中的应用综述
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-03-28 DOI: 10.1515/revce-2021-0072
M. Sharifi, B. Young
Abstract In spite of decades of study and investigation, the research on tomography and electrical resistance tomography (ERT) in particular, remains to be focus of immense scientific significance. ERT provides the ability to measure conductivity distribution inside a process plant and delivers time evolving multidimensional information. Such important and otherwise inaccessible information enhances critical process knowledge whilst improving the design and function of the process equipment. ERT has been employed in a variety of fields including chemical engineering. This paper reviews previous research carried out on the application of ERT within the chemical engineering arena. The applications are classified based on the objective of ERT measurements, the unit operations ERT has been utilized on, the media under examination, and also other technologies and data processing techniques used in combination with ERT. The objective of this taxonomy is to offer the reader with a broad insight into the current situation of ERT related research and developed applications in the chemical engineering field and to assist in the identification of research gaps for future investigation.
尽管经过了几十年的研究和调查,但对断层扫描,特别是电阻断层扫描(ERT)的研究仍然是一个具有重大科学意义的焦点。ERT提供了测量过程工厂内部电导率分布的能力,并提供随时间变化的多维信息。这些重要的和难以获得的信息增强了关键的工艺知识,同时改进了工艺设备的设计和功能。ERT已被应用于包括化学工程在内的许多领域。本文综述了以前在化学工程领域应用ERT的研究。根据ERT测量的目的、ERT所使用的单元操作、所检查的介质以及与ERT结合使用的其他技术和数据处理技术,对应用进行了分类。本分类的目的是为读者提供对化学工程领域ERT相关研究和开发应用的现状的广泛见解,并协助确定未来调查的研究差距。
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引用次数: 0
Research trends in the development of anodes for electrochemical oxidation of wastewater 废水电化学氧化阳极的研究进展
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-03-25 DOI: 10.1515/revce-2021-0067
Devendra K. Rai, Shishir Sinha
Abstract The review focuses on the recent development in anode materials and their synthesis approach, focusing on their compatibility for treating actual industrial wastewater, improving selectivity, electrocatalytic activity, stability at higher concentration, and thereby reducing the mineralization cost for organic pollutant degradation. The advancement in sol–gel technique, including the Pechini method, is discussed in the first section. A separate discussion related to the selection of the electrodeposition method and its deciding parameters is also included. Furthermore, the effect of using advanced heating approaches, including microwave and laser deposition synthesis, is also discussed. Next, a separate discussion is provided on using different types of anode materials and their effect on active •OH radical generation, activity, and electrode stability in direct and indirect oxidation and future aspects. The effect of using different synthesis approaches, additives, and doping is discussed separately for each anode. Graphene, carbon nanotubes (CNTs), and metal doping enhance the number of active sites, electrochemical activity, and mineralization current efficiency (MCE) of the anode. While, microwave or laser heating approaches were proved to be an effective, cheaper, and fast alternative to conventional heating. The electrodeposition and nonaqueous solvent synthesis were convenient and environment-friendly techniques for conductive metallic and polymeric film deposition.
摘要综述了阳极材料及其合成方法的最新进展,重点介绍了它们在处理实际工业废水中的相容性,提高了选择性、电催化活性、高浓度稳定性,从而降低了有机污染物降解的矿化成本。第一节讨论了溶胶-凝胶技术的进展,包括Pechini方法。还包括与电沉积方法的选择及其决定参数有关的单独讨论。此外,还讨论了使用先进加热方法(包括微波和激光沉积合成)的效果。接下来,对使用不同类型的阳极材料及其在直接和间接氧化中对活性•OH自由基生成、活性和电极稳定性的影响以及未来方面进行了单独的讨论。分别讨论了使用不同合成方法、添加剂和掺杂对每个阳极的影响。石墨烯、碳纳米管(CNTs)和金属掺杂提高了阳极的活性位点数量、电化学活性和矿化电流效率(MCE)。然而,微波或激光加热方法被证明是传统加热的有效、廉价和快速的替代方法。电沉积和非水溶剂合成是一种方便、环保的金属导电膜和聚合物导电膜沉积技术。
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引用次数: 2
Recent progress in homogeneous hydrogenation of carbon dioxide to methanol 二氧化碳均相加氢制甲醇的研究进展
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-03-18 DOI: 10.1515/revce-2021-0036
S. J. Poormohammadian, F. Bahadoran, G. Vakili-Nezhaad
Abstract The requirement of running a new generation of fuel production is inevitable due to the limitation of oil production from reservoirs. On the other hand, enhancing the CO2 concentration in the atmosphere brings global warming phenomenon and leads to catastrophic disasters such as drought and flooding. Conversion of carbon dioxide to methanol can compensate for the liquid fuel requirement and mitigate CO2 emissions to the atmosphere. In this review, we surveyed the recent works on homogeneous hydrogenation of CO2 to CH3OH and investigated the experimental results in detail. We categorized the CO2 hydrogenation works based on the environment of the reaction, including neutral, acidic, and basic conditions, and discussed the effects of solvents’ properties on the experimental results. This review provides a perspective on the previous studies in this field, which can assist the researchers in selecting the proper catalyst and solvent for homogenous hydrogenation of carbon dioxide to methanol.
由于油藏产油量的限制,新一代燃料生产的要求是不可避免的。另一方面,大气中二氧化碳浓度的增加带来全球变暖现象,导致干旱、洪水等灾难性灾害。将二氧化碳转化为甲醇可以弥补液体燃料的需求,并减少二氧化碳排放到大气中。本文综述了近年来有关CO2均相加氢制CH3OH的研究进展,并对实验结果进行了详细的分析。根据反应环境对CO2加氢过程进行了分类,包括中性、酸性和碱性条件,并讨论了溶剂性质对实验结果的影响。本文对该领域的研究进展进行了综述,有助于研究人员选择合适的催化剂和溶剂进行二氧化碳均相加氢制甲醇。
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引用次数: 1
Progress in the field of hydrotropy: mechanism, applications and green concepts 水力学领域的进展:机理、应用和绿色概念
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-03-14 DOI: 10.1515/revce-2021-0012
Akash D. Patel, Meghal A. Desai
Abstract Sustainability and greenness are the concepts of growing interest in the area of research as well as industries. One of the frequently encountered challenges faced in research and industrial fields is the solubility of the hydrophobic compound. Conventionally organic solvents are used in various applications; however, their contribution to environmental pollution, the huge energy requirement for separation and higher consumption lead to unsustainable practice. We require solvents that curtail the usage of hazardous material, increase the competency of mass and energy and embrace the concept of recyclability or renewability. Hydrotropy is one of the approaches for fulfilling these requirements. The phenomenon of solubilizing hydrophobic compound using hydrotrope is termed hydrotropy. Researchers of various fields are attracted to hydrotropy due to its unique physicochemical properties. In this review article, fundamentals about hydrotropes and various mechanisms involved in hydrotropy have been discussed. Hydrotropes are widely used in separation, heterogeneous chemical reactions, natural product extraction and pharmaceuticals. Applications of hydrotropes in these fields are discussed at length. We have examined the significant outcomes and correlated them with green engineering and green chemistry principles, which could give an overall picture of hydrotropy as a green and sustainable approach for the above applications.
摘要可持续性和绿色是研究和工业领域越来越感兴趣的概念。在研究和工业领域中经常遇到的挑战之一是疏水性化合物的溶解度。传统上,有机溶剂用于各种应用中;然而,它们对环境污染的贡献、分离所需的巨大能源和更高的消耗导致了不可持续的做法。我们需要减少有害物质使用的溶剂,提高质量和能源的能力,并接受可回收性或可再生性的概念。水力是满足这些要求的方法之一。使用水溶性聚合物溶解疏水性化合物的现象称为水塑性。由于其独特的物理化学性质,水塑性吸引了各个领域的研究人员。在这篇综述文章中,已经讨论了有关水力绳索的基本原理和各种涉及水力的机制。水滑石广泛应用于分离、多相化学反应、天然产物提取和制药。详细讨论了液压绳索在这些领域的应用。我们已经研究了这些重要成果,并将其与绿色工程和绿色化学原理相关联,这可以全面了解水动力作为上述应用的绿色和可持续方法。
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引用次数: 7
Recent developments in MIL-101 metal organic framework for heterogeneous catalysis MIL-101金属有机骨架的多相催化研究进展
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-03-02 DOI: 10.1515/revce-2021-0050
M. Taghizadeh, S. Tahami
Abstract Metal organic frameworks (MOFs) are currently gaining considerable attention as heterogeneous catalysts. Since the functionality of the framework and the pore size of the MOFs can be adjusted over a wide range for various catalytic reactions, the usage of these materials as solid catalysts is attractive. One of the preferred catalytic mesoMOFs is MIL-101 (MIL: Material of Institute Lavoisier) family which has been mainly investigated. The large surface area, high pore volumes, and acceptable solvent/thermal stability (MIL-101(Cr) up to 300 °C) have led the MIL-101 family to be considered an ideal and widespread MOF for use as a great heterogeneous catalyst or solid support for a variety of reactions. The objective of this review is to present recent research on the use of the MIL-101 family for heterogeneous catalysis in gas and liquid phase reactions.
摘要金属有机骨架(MOFs)作为非均相催化剂,目前正受到越来越多的关注。由于框架的功能性和MOFs的孔径可以在宽范围内调节用于各种催化反应,因此将这些材料用作固体催化剂是有吸引力的。优选的催化介电MOFs之一是MIL-101(MIL:拉瓦锡研究所材料)家族,该家族已被主要研究。大的表面积、高的孔体积和可接受的溶剂/热稳定性(MIL-101(Cr)高达300°C)使MIL-101家族被认为是一种理想且广泛的MOF,用作各种反应的大的非均相催化剂或固体载体。这篇综述的目的是介绍MIL-101家族在气相和液相反应中用于多相催化的最新研究。
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引用次数: 5
Potentials of bio-butanol conversion to valuable products 生物丁醇转化为有价值产品的潜力
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-02-02 DOI: 10.1515/revce-2021-0066
L. Pinaeva, A. Noskov
Abstract In the last decade, there was observed a growing demand for both n-butanol as a potential fuel or fuel additive, and propylene as the only raw material for production of alcohol and other more bulky propylene chemical derivatives with faster growing outputs (polymers, propylene oxide, and acrylic acid). The predictable oilfield depletion and the European Green Deal adoption stimulated interest in alternative processes for n-butanol production, especially those involving bio-based materials. Their commercialization will promote additional market penetration of n-butanol for its application as a basic chemical. We analyze briefly the current status of two most advanced bio-based processes, i.e. ethanol–to-n-butanol and acetone–butanol–ethanol (ABE) fermentation. In the second part of the review, studies of n-butanol and ABE conversion to valuable products are considered with an emphasis on the most perspective catalytic systems and variants of the future processes realization.
在过去的十年中,人们观察到正丁醇作为一种潜在的燃料或燃料添加剂的需求不断增长,丙烯作为生产酒精和其他产量增长更快的体积更大的丙烯化学衍生物(聚合物、环氧丙烷和丙烯酸)的唯一原料。可预测的油田枯竭和欧洲绿色协议的采用激发了人们对正丁醇生产替代工艺的兴趣,特别是那些涉及生物基材料的工艺。它们的商业化将促进正丁醇作为一种基础化学品的进一步市场渗透。本文简要分析了两种最先进的生物基工艺的现状,即乙醇制正丁醇和丙酮-丁醇-乙醇(ABE)发酵。在第二部分,综述了正丁醇和ABE转化为有价值产品的研究,重点介绍了最有前景的催化体系和未来工艺实现的变体。
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引用次数: 3
Mesoporous catalysts for catalytic oxidation of volatile organic compounds: preparations, mechanisms and applications 用于挥发性有机化合物催化氧化的介孔催化剂:制备、机理和应用
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-02-01 DOI: 10.1515/revce-2021-0029
Jing Wang, Peifen Wang, Zhijun Wu, Tao Yu, A. Abudula, Mingzhu Sun, Xiaoxun Ma, Guoqing Guan
Abstract Volatile organic compounds (VOCs) are mainly derived from human activities, but they are harmful to the environment and our health. Catalytic oxidation is the most economical and efficient method to convert VOCs into harmless substances of water and carbon dioxide at relatively low temperatures among the existing techniques. Supporting noble metal and/or transition metal oxide catalysts on the porous materials and direct preparation of mesoporous catalysts are two efficient ways to obtain effective catalysts for the catalytic oxidation of VOCs. This review focuses on the preparation methods for noble-metal-based and transition-metal-oxide-based mesoporous catalysts, the reaction mechanisms of the catalytic oxidations of VOCs over them, the catalyst deactivation/regeneration, and the applications of such catalysts for VOCs removal. It is expected to provide guidance for the design, preparation and application of effective mesoporous catalysts with superior activity, high stability and low cost for the VOCs removal at lower temperatures.
摘要挥发性有机化合物主要来源于人类活动,但对环境和人体健康有害。催化氧化是现有技术中在相对较低的温度下将挥发性有机物转化为水和二氧化碳无害物质的最经济有效的方法。在多孔材料上负载贵金属和/或过渡金属氧化物催化剂和直接制备介孔催化剂是获得有效催化氧化VOCs催化剂的两种有效途径。综述了贵金属基和过渡金属氧化物基介孔催化剂的制备方法、它们催化氧化挥发性有机物的反应机理、催化剂的失活/再生以及这些催化剂在去除挥发性有机物中的应用。它有望为设计、制备和应用具有优异活性、高稳定性和低成本的高效中孔催化剂提供指导,用于在较低温度下去除挥发性有机物。
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引用次数: 2
Frontmatter Frontmatter
IF 4.7 3区 工程技术 Q1 Chemical Engineering Pub Date : 2022-02-01 DOI: 10.1515/revce-2022-frontmatter2
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引用次数: 0
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Reviews in Chemical Engineering
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