This study presents a novel investigation into the impact of non-Gaussian characteristics on wind pressure peak factors and extreme values in photovoltaic structural panels, addressing a critical gap in current design methodologies. A wind tunnel test was conducted on a rigid model of an adjustable-tilt solar photovoltaic system, providing essential panel wind pressure data. Through a comprehensive analysis of wind pressure time history, probability density, skewness, kurtosis, and statistical distributions, this research identified distinct non-Gaussian characteristics and highlighted sensitive areas on the panel. The study utilized three extreme value estimation methods to calculate peak wind pressures and compared their accuracy. Results demonstrate that the GPD method offers the most precise calculations of extreme wind pressure, outperforming traditional Gaussian-based approaches, which often underestimate peak pressures by 30%–50%. Additionally, the comparison of full-direction wind data with single wind direction extremes reveals potential overestimations in design values, suggesting that using one-directional extremes could inflate extreme wind pressure by 1.1–1.25 times for positive and 1.1 to 1.15 times for negative values. This study underscores the necessity of incorporating non-Gaussian features and full-direction wind considerations in the structural design of photovoltaic systems to avoid underestimation or over-design, particularly in sensitive regions. These findings contribute valuable insights for enhancing the precision and safety of structural design in renewable energy applications.