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Advancements in hyperpigmentation management: exploring conventional methods, phytoconstituents, novel approaches, and instrumental techniques.
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2025-01-28 DOI: 10.1080/14764172.2025.2455157
Arpana S Patil, Archana S Patil, Pratik Ugare, Esha Jain, Rajashree S Masareddy

Hyperpigmentation is a common dermatological condition characterized by the darkening of patches of skin compared to the surrounding areas. It can occur in individuals of all skin types and ethnicities, and is caused by an overproduction or accumulation of melanin, the pigment responsible for the color of our skin, hair, and eyes. This comprehensive overview aims to delve into the various types, causes, risk factors, clinical manifestations, diagnosis, and treatment options for hyperpigmentation. Additionally, it explores the global and national prevalence of hyperpigmentation, its etiology, pathophysiology and diagnosis and treatment strategies. Furthermore, examines the formulations and dosage forms used to treat hyperpigmentation, including their side effects. It also discusses combination drugs and their associated side effects, as well as novel drug delivery systems and nanocarriers employed in the treatment of hyperpigmentation, providing insight into future prospects in this field.

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引用次数: 0
Use of a fractional 1570-nm diode laser scanner for nonablative face and neck rejuvenation. 使用分数型1570纳米二极管激光扫描仪进行非烧蚀性面部和颈部年轻化。
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2025-01-02 DOI: 10.1080/14764172.2024.2441702
Munir Somji, Tino Solomon

Background: The use of non-ablative fractionated lasers for skin rejuvenation has been proven to be effective in improving skin texture, and has become popular due to minimal wounding, significantly shorter recovery times and decreased adverse effects.

Objective: To retrospectively analyze improvement in skin texture in healthy women aged over 18 years with Fitzpatrick skin type II-IV.

Methods: Participants received 3 facial and/or neck treatments with the 1570-nm fractional scanning diode laser at one-month intervals. Three months after the last treatment session two blinded evaluators assessed skin improvement using before and after photos. Pain and patient satisfaction were recorded.

Results: Sixteen women with a mean age of 45.4 ± 4.1 years (range 35-50 years) and skin type II-IV were included in the analysis. All 16 participants received facial treatments and seven (43.8%) also received neck treatments. Three months follow-up evaluation showed that the majority of participants had at least a visible change in the treated areas. Mean pain score was low and decreased with each treatment session.

Conclusion: Skin treatment using fractional scanning 1570-nm diode laser improves skin laxity in women with skin types II-IV. Larger studies are warranted to further clarify the efficacy and safety of this modality.

背景:使用非烧蚀分割激光进行皮肤再生已被证明可以有效改善皮肤质地,并且由于最小的伤害,显着缩短恢复时间和减少不良反应而受到欢迎。目的:回顾性分析18岁以上Fitzpatrick II-IV型健康女性皮肤质地的改善情况。方法:受试者每隔一个月接受3次1570纳米分数扫描二极管激光面部和/或颈部治疗。最后一次治疗三个月后,两位盲法评估者使用治疗前后的照片评估皮肤改善情况。记录疼痛和患者满意度。结果:16例女性纳入分析,平均年龄45.4±4.1岁(35-50岁),皮肤类型II-IV。所有16名参与者都接受了面部治疗,7名(43.8%)也接受了颈部治疗。三个月的随访评估显示,大多数参与者在治疗区域至少有明显的变化。平均疼痛评分较低,且随每次治疗而降低。结论:分次扫描1570 nm二极管激光皮肤治疗可改善II-IV型女性皮肤松弛。需要更大规模的研究来进一步阐明这种方式的有效性和安全性。
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引用次数: 0
Skin necrosis after autologous fat grafting for augmentation rhinoplasty: a case report and review of the literature. 自体脂肪移植隆鼻术后皮肤坏死1例报告及文献复习。
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2024-12-31 DOI: 10.1080/14764172.2024.2421013
Xiao Jiang, Hanchen Cao, Xingfeng He, Xinhui Zou, Haoran Mao, Lingzhi Tang, Jinqiang Lu

Background: Autologous fat transplantation has gained increasing attention in the field of cosmetic surgery. However, a series of complications can occur after fat transplantation.

Case presentation: A 24-year-old woman presented at our Hospital with nasal skin necrosis and ulceration. She had undergone autologous fat transplantation on the nose six days ago. Physical examination showed an abnormal skin range of approximately 5 × 2 cm on the left side of the nose. The initial diagnosis was "skin necrosis after autologous fat grafting for augmentation rhinoplasty." In addition to the conventional treatment, topical oxygen therapy (TOT) and platelet-rich fibrin (PRF) injection were applied to the nasal wounds area. After 16 days, the pale and dark areas of necrosis on nose were scabby, and the local skin conditions were significantly improved.

Conclusion: We treated a case of ischemic necrosis of the skin after autologous fat grafting for augmentation rhinoplasty. For this kind of local vascular embolism, we first proposed a comprehensive therapy of "biological + physical + drug." The therapeutic method achieved satisfactory results, providing a new strategy for the clinical treatment of vascular embolism.

背景:自体脂肪移植在美容外科领域受到越来越多的关注。然而,脂肪移植后会出现一系列并发症。病例介绍:一名24岁女性因鼻皮肤坏死和溃疡来我院就诊。她六天前做了鼻子自体脂肪移植手术。体格检查显示鼻左侧皮肤异常范围约5 × 2 cm。最初的诊断是“自体脂肪移植隆鼻术后皮肤坏死”。在常规治疗的基础上,应用局部氧疗(TOT)和富血小板纤维蛋白(PRF)注射于鼻创面。16 d后,鼻部苍白、深色坏死区结痂,局部皮肤状况明显改善。结论:我们治疗了一例自体脂肪移植隆鼻术后皮肤缺血性坏死。针对这种局部血管栓塞,我们首次提出了“生物+物理+药物”的综合治疗方案。该治疗方法取得了满意的效果,为临床治疗血管栓塞提供了新的策略。
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引用次数: 0
A case of resistant granuloma faciale successfully treated with ablative fractional carbon dioxide laser. 用二氧化碳激光烧蚀点阵成功治疗一例耐药性面部肉芽肿。
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2024-10-29 DOI: 10.1080/14764172.2024.2421019
Amy Prideaux, Emma Hitchens, Kay Thomas, Hannah Wainman, Daniel Keith

Granuloma faciale is a benign and rare skin disease, which usually presents as well-defined red-purple asymptomatic plaques or nodules on the face but can also present extra-facially. It poses a significant therapeutic challenge, with varying degrees of success reported by a range of medical and surgical treatments. We describe a 41-year-old lady with biopsy-confirmed facial granuloma faciale, affecting her nose, cheeks, upper lip, and forehead, who had failed a variety of medical treatments, UVB phototherapy, and pulsed dye laser. She was successfully treated with ablative fractional CO2 laser, with a sustained response, without recurrence or complications maintained for 1 year.

面部肉芽肿是一种罕见的良性皮肤病,通常表现为面部界限清楚的红紫色无症状斑块或结节,也可表现为面部以外的症状。它给治疗带来了巨大的挑战,据报道,一系列药物和手术治疗都取得了不同程度的成功。我们描述了一位 41 岁的女士,她的面部肉芽肿经活检确诊,累及鼻子、脸颊、上唇和前额。她接受了二氧化碳点阵消融激光治疗,并取得了成功,治疗效果持续了一年,没有复发或并发症。
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引用次数: 0
The assessment of the impact of carboxytherapy and selected chemical peels on cosmetic defects and signs of aging of skin around eyes. 评估羧基疗法和特定化学换肤对眼周皮肤美容缺陷和衰老迹象的影响。
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2024-08-13 DOI: 10.1080/14764172.2024.2390584
Anna Kołodziejczak, Helena Rotsztejn

Objective: The purpose of this study was to assess changes in skin elasticity and other skin defects related to the aging of skin around eyes following the use of combination treatment carboxytherapy and chemical peels (ferulic acid combined with ascorbic acid, lactobionic acid).

Material and methods: A total of 39 Caucasian patients were subjected to a series of five combination carboxytherapy and chemical peels treatments at weekly intervals. The Cutometer device was used to objectively measure skin elasticity. The assessment was supplemented by photographic documentation.

Results: A statistically significant improvement in skin elasticity assessed on the basis of R2 and R7 parameters (p < .0001, p = .001, respectively) was demonstrated after a series of five sessions of carboxytherapy combined with chemical peels. The improvement in the R2 parameter was observed in 82.1%, while R7 in 76.9% of study participants. It observed that the number of participants who benefited from treatment with ferulic acid and ascorbic acid was statistically higher compared with the second group (p = .036). Improved R2 values were reported in 100% of participants undergoing carboxytherapy combined with ferulic and ascorbic acid.

Conclusion: Carboxytherapy in combination with chemical peels improved skin elasticity and can be used to reduce other skin defects.

研究目的本研究的目的是评估羧基疗法和化学换肤(阿魏酸联合抗坏血酸、乳糖酸)联合治疗后眼周皮肤弹性的变化以及与眼周皮肤老化有关的其他皮肤缺陷:共对 39 名白种人患者进行了五次羧基疗法和化学换肤联合治疗,每次治疗间隔一周。使用 Cutometer 设备客观测量皮肤弹性。评估还辅以照片记录:结果:经过五次羧基疗法和化学换肤治疗后,根据 R2 和 R7 参数评估,皮肤弹性有了明显改善(分别为 p p = .001)。82.1%的参与者的 R2 参数有所改善,76.9%的参与者的 R7 参数有所改善。研究发现,与第二组相比,阿魏酸和抗坏血酸治疗的受益人数在统计学上更高(p = .036)。100%接受羧基疗法联合阿魏酸和抗坏血酸治疗的参与者的R2值都有所改善:结论:羧基疗法结合化学换肤可改善皮肤弹性,并可用于减少其他皮肤缺陷。
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引用次数: 0
A clinical study on the efficacy of high frequency therapy on nasolabial and periorbital wrinkles. 高频疗法对鼻唇和眶周皱纹疗效的临床研究。
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2024-11-14 DOI: 10.1080/14764172.2024.2427018
Ana Keila Ferreira Dos Santos, Cintia Cristina Santi Martignago, Ana Laura Martins de Andrade, Livia Assis, Rodrigo Sávio Pessoa, Danieldos Anjos Costa, Laurita Dos Santos, Carla Tim

The high-frequency generator is considered a collagen stimulator and skin revitalizer, however there are few studies exploring its effects in the field of rejuvenation and aesthetics. Thus, this study aimed to investigate the impact of high frequency generator therapy on facial aging. A total of 26 participants aged between 50 and 60 years were selected and received high frequency generator treatment for eight weeks. The evaluation was conducted using a combination of photographic records and assessment tools, including Rosenberg scale, perception and satisfaction with treatment evaluation, overall aesthetic improvement scale, and modified Fitzpatrick scale. The analysis conducted by the Global Aesthetic Improvement Scale yielded significant results. The Modified Fitzpatrick Wrinkle Scale showed that high frequency therapy led to statistically significant improvements in the appearance of nasolabial wrinkles (right T0: 1.48, T8: 0.87; left T0: 1.51, T8: 1.05) and periorbital wrinkles (right T0: 1.69, T8: 1.05; left T0: 1.71, T8: 1.08). In conclusion, high frequency generator therapy can be a highly effective tool for treating skin aging on the face, however, we recommend that future research includes control groups, and adopts objective measures to expand knowledge about the effects of high frequency.

高频发生器被认为是胶原蛋白刺激器和皮肤活化剂,但很少有研究探讨其在年轻化和美学领域的效果。因此,本研究旨在探讨高频发生器疗法对面部衰老的影响。研究共选取了 26 名年龄在 50 至 60 岁之间的参与者,他们接受了为期八周的高频发生器治疗。评估结合了照片记录和评估工具,包括罗森伯格量表、治疗感知和满意度评估、整体美学改善量表和改良菲茨帕特里克量表。整体美学改善量表的分析结果显示,治疗效果显著。改良菲茨帕特里克皱纹量表显示,高频治疗对鼻唇皱纹(右侧 T0:1.48,T8:0.87;左侧 T0:1.51,T8:1.05)和眶周皱纹(右侧 T0:1.69,T8:1.05;左侧 T0:1.71,T8:1.08)的改善具有统计学意义。总之,高频发生器疗法是治疗面部皮肤老化的一种非常有效的工具,但我们建议今后的研究应包括对照组,并采用客观的测量方法,以扩大对高频效果的了解。
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引用次数: 0
Intralesional vitamin D3 versus intralesional triamcinolone acetonoid in patchy alopecia areata: a comparative clinical and dermoscopic study. 斑片状脱发患者穴内注射维生素 D3 与穴内注射曲安奈德:临床与皮肤镜对比研究。
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2024-08-14 DOI: 10.1080/14764172.2024.2389275
Maha H Ragaie, Shimaa E Mohammed, Shimaa S Shehata

Background: Alopecia areata (AA) is a common autoimmune T-cell mediated non-scarring, form of hair loss. It affects people of all ages and sexes.

Aim: To compare the efficacy of intralesional vitamin D3 injection versus that of intralesional triamcinolone acetonide in the treatment of patchy alopecia areata.

Patients and methods: This clinical study was carried on 40 adult patients with patchy alopecia areata, the patients were categorized into two groups. Group I involved 20 patients who received 1 ml of intralesional injection of vitamin D3 (cholecalciferol aqueous preparation 200 000 IU/2 ml) every 4 weeks for a maximum of three sessions. Group II involved 20 patients who received 1 ml of intralesional injection of triamcinolone acetonide 40 mg/mL every 4 weeks for a maximum of three sessions. Clinical and trichoscopic evaluations were done at the baseline, each session and for 3 months after the last session.

Results: There was no statistically significant difference between the two studied groups regarding the degree of clinical improvement (p = .8). A statistically significant reduction in AA specific trichoscopic signs was detected at the end of the sessions and after 3 months of follow-up in both groups, without any statistically significant difference between them. Also a statistically significant difference was found between both groups regarding the reported adverse effects with a significant better patient satisfaction encountered toward the intralesional vitamin D3 injection.

Conclusion: Intralesional vitamin D3 is a promising effective, simple, safe, and inexpensive, therapeutic modality for patchy AA.

背景:斑秃(AA)是一种常见的自身免疫性T细胞介导的非瘢痕性脱发。目的:比较鞘内注射维生素 D3 和鞘内注射曲安奈德治疗斑片状脱发的疗效:这项临床研究以40名成年斑片状脱发患者为对象,将患者分为两组。第一组 20 名患者每 4 周接受 1 毫升维生素 D3(胆钙化醇水制剂 200 000 IU/2 毫升)的局部注射,最多 3 次。第二组有 20 名患者,他们每 4 周接受一次 1 毫升 40 毫克/毫升的曲安奈德内注射,最多三次。在基线、每次疗程和最后一次疗程后的 3 个月内,对患者进行了临床和三腔镜评估:结果:在临床改善程度方面,两个研究组之间没有明显的统计学差异(P = .8)。在疗程结束后和 3 个月的随访中,两组患者的 AA 特异性三腔镜体征均有明显减少,但无统计学差异。此外,在不良反应方面,两组之间也存在统计学意义上的显著差异,患者对点内注射维生素 D3 的满意度明显更高:结论:局部注射维生素 D3 是治疗斑片状 AA 的一种有效、简单、安全、廉价的治疗方法。
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引用次数: 0
Blue light diode laser for treating benign maxillofacial vascular lesions: comparison of various techniques using the same diode laser. 用于治疗颌面部良性血管病变的蓝光二极管激光器:使用相同二极管激光器的各种技术比较。
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2024-11-28 DOI: 10.1080/14764172.2024.2433215
M Gobbo, M Val, L Guarda Nardini

Maxillofacial benign vascular lesions may require removal for aesthetic purpose or bleeding. Lasers have been substituting traditional excision. Fifteen vascular lesions were treated with different Blue Diode Laser protocols: laser forced dehydration (LFD), intralesional coagulation (ILC), surgical excision. LFD is conservative, quick and does not need anesthesia. ILC was used as second choice and surgical excision when both techniques failed. One patient reported asymptomatic ulceration after LFD and one patient referred bleeding after ILC. None experienced pain or relapse. Lasers are useful for treating vascular benign lesions. Surgical excision should be left as utmost treatment especially in case of aesthetic concern.

颌面部良性血管病变可能因美观或出血而需要切除。激光已经取代了传统的切除术。15 例血管病变采用了不同的蓝色二极管激光方案进行治疗:激光强制脱水(LFD)、区域内凝固(ILC)和手术切除。激光强制脱水疗法保守、快速,无需麻醉。ILC 是第二选择,当两种技术都失败时,则进行手术切除。一名患者报告在 LFD 术后出现无症状溃疡,一名患者在 ILC 术后出现出血。没有人感到疼痛或复发。激光可用于治疗血管良性病变。手术切除应作为最重要的治疗方法,尤其是在影响美观的情况下。
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引用次数: 0
A comparison of surgical scar treatment using various combinations of autologous fat, hyaluronic acid and resurfacing with the 1540 nm non-ablative Erbium laser - a prospective pilot study. 使用自体脂肪、透明质酸和 1540 纳米非烧蚀铒激光换肤的各种组合治疗手术疤痕的比较--一项前瞻性试验研究。
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2024-08-20 DOI: 10.1080/14764172.2024.2390585
Meir Retchkiman, Ofir Ron, Barak Stuchiner, Yoav Gronovich

Scars can cause aesthetic or functional disturbance. Several interventions had been described to improve their appearance. We propose that the combination of some of those treatments can synergize their effects on the scar. We designed a prospective pilot study with ten patients using the patient as their own control to compare different interventions. In each patient, the scar was divided into four parts treated differently: 1. No treatment (control), 2. Fat grafting only, 3. Fat grafting and Hyaluronic Acid (HA), 4. Fat grafting, HA and with a non-fractional laser. Each part of the scar was evaluated by the Patient and Observer Scar Assessment Scale (POSAS). Treatment of the scar with the combination of the three modalities showed better results in the observer scale. In addition, a combination of fat injection, HA, and subsequent skin resurfacing with non-ablative laser showed better outcomes for all parameters on the Observer Scale except vascularity, while on the Patient Scale thickness, relief, pliability, surface area, and overall measurement were better. The combination of all three treatments tends to improve scarring results and appears to be safe and effective. However, further studies with larger samples are needed to explore the potential use of this combined treatment.

疤痕会影响美观或功能。有几种干预措施可以改善疤痕的外观。我们建议,将其中一些治疗方法结合起来,可以协同作用于疤痕。我们设计了一项前瞻性试验研究,以十名患者为对照,比较不同的干预措施。每名患者的疤痕都被分为四个部分,以不同的方式进行治疗:1.1.不治疗(对照组);2.仅脂肪移植;3.脂肪移植和透明质酸(HA);4.脂肪移植、透明质酸和非点阵激光。患者和观察者疤痕评估量表(POSAS)对疤痕的各个部分进行了评估。在观察者评定量表中,三种方法联合治疗疤痕的效果更好。此外,脂肪注射、HA 和随后的非烧蚀激光焕肤疗法的组合在观察者量表中除血管外的所有参数上都显示出更好的效果,而在患者量表中,厚度、松弛度、柔韧性、表面积和整体测量结果都更好。这三种治疗方法的联合使用往往能改善疤痕效果,而且似乎安全有效。不过,还需要对更多样本进行进一步研究,以探索这种联合疗法的潜在用途。
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引用次数: 0
Pulsed dye laser in jellyfish-induced keloids. 脉冲染料激光治疗水母诱发的瘢痕疙瘩
IF 1.2 4区 医学 Q3 DERMATOLOGY Pub Date : 2024-11-16 Epub Date: 2024-10-31 DOI: 10.1080/14764172.2024.2420990
Astrid Herzum, Gianmaria Viglizzo, Lodovica Gariazzo, Carlotta Pastorino, Nadia Casteni, Corrado Occella

Jellyfish stings can cause acute inflammatory skin lesions that may hesitate in keloids. Pulsed dye laser (PDL) represents one of the most effective treatments for newly developed keloids. Aim of this study was to evaluate the efficacy of PDL on newly developed keloids specifically induced by jellyfish stings in pediatric patients.We conducted a retrospective observational study on pediatric patients with newly developed keloids from jellyfish stings, treated in the last two years with 595 nm wavelength PDL with a duration of 0.45-1.5 msec, spot-size 7 mm and fluence 8.5-9.5 J/cm2. PDL therapy was administered for a mean of 7.4 treatment sessions, every 1-3 months. Two expert dermatologists evaluated the vascularity, pigmentation, height, and pliability of keloids, according to the Vancouver Scar Scale (VSS), pre-and-post treatment. A total of 17 patients (7 males, 10 females) were included in the study, mean age of 11 years. Overall, mean pre-treatment global VSS was 11.0 ± 1.50. After treatment, global VSS was 3.88 ± 1.87. At paired t-test, the difference between pre-treatment and post-treatment was highly statistically significant (p < .0001). Commonly, manipulation and therapeutic intervention on jellyfish scars and keloids is feared. The present study supports the use of PDL in keloids secondary to jellyfish stings, though conducted on a limited number of patients.

水母蜇伤可引起急性炎症性皮肤损伤,并可能导致瘢痕疙瘩。脉冲染料激光(PDL)是治疗新发瘢痕疙瘩最有效的方法之一。我们对过去两年中因水母蜇伤而新发瘢痕疙瘩的儿科患者进行了一项回顾性观察研究,患者接受了波长为595 nm、持续时间为0.45-1.5毫秒、光斑大小为7毫米、能量为8.5-9.5焦耳/平方厘米的脉冲染料激光治疗。PDL 治疗平均每 1-3 个月进行一次,每次 7.4 个疗程。根据温哥华瘢痕量表(VSS),两位皮肤科专家在治疗前后对瘢痕疙瘩的血管、色素沉着、高度和柔韧性进行了评估。共有 17 名患者(7 男 10 女)参与了研究,平均年龄为 11 岁。总体而言,治疗前的总体 VSS 平均值为 11.0 ± 1.50。治疗后,总体 VSS 为 3.88 ± 1.87。经配对 t 检验,治疗前和治疗后的差异具有高度统计学意义(p
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引用次数: 0
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Journal of Cosmetic and Laser Therapy
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