Journal of Cosmetic and Laser Therapy最新文献

Background: Low-level laser therapy (LLLT) at 675 nm, within the red light spectrum, has emerged as a noninvasive therapeutic option for various dermatological conditions, including aging-related skin changes, melasma, acne vulgaris, and striae distensae.

Aims: This review aims to elucidate the therapeutic potential of the 675 nm laser in dermatology by synthesizing existing research evidence and clinical outcomes.

Methods: A literature search was conducted on PubMed to include studies investigating the efficacy of the 675 nm laser in diverse dermatological conditions. Parameters such as treatment protocols, patient demographics, and outcome measures were analyzed to assess the laser's therapeutic associations. The literature search composed of clinical trials or review articles. Studies were additionally identified by searching reference lists of included articles. Only articles in English were utilized for this review.

Results: The 675 nm laser demonstrates efficacy in addressing aging-related skin changes, including facial rejuvenation and wrinkle reduction, with significant improvement observed in skin texture and collagen remodeling. Additionally, the laser exhibits promising outcomes in treating melasma and hyperpigmentation disorders, acne vulgaris, and striae distensae, offering selective damage to target tissues with minimal adverse effects.

Conclusions: The 675 nm laser presents a versatile and innovative therapeutic option in dermatology, offering noninvasive treatment modalities for various health and cosmetic concerns. Further research and clinical trials are warranted to optimize treatment protocols and fully elucidate its therapeutic potential in diverse patient populations.

Basal cell carcinoma (BCC) is the most prevalent skin cancer, belonging to a group of skin cancers, namely Non-melanoma skin cancers. The increasing annual incidence, cosmetic disfigurements, and high recurrence rates give prominence to the role of the treatment methods used. Although there are numerous treatment modalities, pulsed dye laser (PDL) has emerged as an effective treatment for basal cell carcinoma in recent years. In this review, we aimed to assess the efficacy of pulsed dye laser on basal cell carcinoma in previous studies.

Lip augmentation (LA) procedures can cause complications such as edema, erythema, and pain. Photobiomodulation therapy (PBMT) has been indicated as a promissory alternative therapy. We evaluated different PBMT protocols on the management of its complications. Sixty-one patients post-LA were divided into four groups: control; PBMT λ660 nm; PBMT λ808 nm; and PBMT λ660 and 808 nm simultaneously. A higher analgesia was observed in the PBMT λ660 nm group. Upper-lip edema only decreased in the PBMT λ808 nm. Erythema increased in the control, whereas the PBMT groups had smaller score variations. PBMT emitting 660 or 808 nm was efficient for the treatment of edema and erythema post-LA.

Hyperpigmentation is a common dermatological condition characterized by the darkening of patches of skin compared to the surrounding areas. It can occur in individuals of all skin types and ethnicities, and is caused by an overproduction or accumulation of melanin, the pigment responsible for the color of our skin, hair, and eyes. This comprehensive overview aims to delve into the various types, causes, risk factors, clinical manifestations, diagnosis, and treatment options for hyperpigmentation. Additionally, it explores the global and national prevalence of hyperpigmentation, its etiology, pathophysiology and diagnosis and treatment strategies. Furthermore, examines the formulations and dosage forms used to treat hyperpigmentation, including their side effects. It also discusses combination drugs and their associated side effects, as well as novel drug delivery systems and nanocarriers employed in the treatment of hyperpigmentation, providing insight into future prospects in this field.

Areolar Sebaceous Hyperplasia (ASH) consists of enlarged Montgomery tubercles, skin-colored papules in the peripheral border of the areola, formed by the openings of the ducts of Montgomery's glands. Treatment options are only briefly discussed in literature as it is mostly presented as asymptomatic or paucisymptomatic. However, this traditional standpoint does not take into consideration the psychological impact that it may have on the patient. We present a case of prominent Montgomery tubercles treated with CO2 laser with good response.

Filler injection-associated alopecia is a rare complication. To date, including our case, we have identified 17 reported cases of alopecia following filler injection. Although uncommon, this complication should not be overlooked, especially given the increasing popularity of cosmetic procedures and the potential for misuse by unqualified individuals. In our case, unilateral partial cicatricial alopecia developed in the temporoparietal region following hyaluronic acid (HA) filler injection into the temporal area. The patient presented one month after the procedure, with no signs of vascular occlusion. Topical minoxidil was prescribed, resulting in approximately 80% hair regrowth in the affected area.

The process of face aging is characterized by various signs, including nasolabial folds, sagging and hollowing, all of which worsen with age. In some subjects, this phenomenon is exacerbated by sun exposure, bad diet, genetic factor, pollution, etc. This remains a great concern as it impacts physiologically and psychologically on patient quality of life. The intradermal solution based on bio-fermentative HA is indicated for correction of skin damages including rhytidosis, photoaging and skin dehydration. The present clinical investigation was designed for obtaining further clinical safety and efficacy data for the SKIN R intradermal solution for the treatment of skin damages. The efficacy of the treatments was assessed by measuring the pH, assessment of sebometry, and hydrometry, Global Aesthetic Improvement Scale and Subject satisfaction. All 15 screened and enrolled subjects were treated with the investigational device at least once. All subjects who were assessed had a neck photo taken at visits 1 and 2. The subjects' judgment of appearance after treatment changed with time, however, by the termination of the study on Day 60, 33.3% of subjects still considered their appearance very much improved, and 46,6% still considered their appearance much improved. The assessment of "satisfaction with treatment" was very high by the majority of subjects. No major adverse event was recorded. In conclusion, SKIN R is safe and well-tolerated and is effective in the treatment of skin damage.

Acne keloidalis nuchae (AKN) is a scarring folliculitis characterized by papules, pustules, and tumor-like masses on the neck and scalp. Management varies with severity; mild cases respond to topical treatments, while severe cases may require systemic therapies or surgical interventions. We present two tumor-stage AKN cases successfully treated with electrosurgical excision and loop cautery, followed by secondary intention healing. In Case 1, a 38-year-old male with extensive keloidal plaques achieved significant improvement after electrosurgical excision. In Case 2, a 19-year-old male with recurrent pustules saw notable cosmetic and symptomatic relief from loop cautery. Both techniques proved effective and enhanced healing.

Body contouring procedures are defined as modification of the body's appearance through changes in size or shape. RF energy applied to a specific skin layer leads to either dermal remodeling or fat reduction. The multi-polar RF handpiece was used once a week for a treatment course of 3-8 sessions. The clinical evaluation of 40 patients showed no significant adverse and some degree of circumferential reduction with moderate positive correlation to BMI in 100% of patients. The blinded evaluation demonstrated a 35% improvement in "skin laxity grade" with an average rate of "moderate improvement." The in-vivo histopathological analysis showed no acute heat injury as well as power-related progressive increase of fibroblasts proliferation and neocollagenesis. The device represents an effective treatment for skin laxity with a 100% response rate and long-term safety profile.

Mohs micrographic surgery (MMS) is the gold standard treatment for skin cancers of the face, but scarring in these cosmetically sensitive areas remains a challenge, with no clear consensus on the most effective treatments. This study reviews the literature on therapies for specifically facial scars following Mohs surgery, emphasizing their mechanism of action and evidence of efficacy. Non-invasive options such as topical silicone and pressure therapy have shown benefits, while advanced techniques like dermabrasion, microneedling, or energy devices like the pulse-dye, CO2, Erbium, and Nd:YAG lasers, show promise in improving scar pliability and visibility. Intralesional injections of corticosteroids, botulinum toxin, and dermal fillers also have supportive data. Conversely, treatments like topical onion extract and vitamin E lack evidence of efficacy. Managing hypertrophic granulation tissue (HGT) also remains critical to reduce aberrant scarring from second-intention healing (SIH). To ensure optimal clinical outcomes, clinicians should remain updated on the wide range of scar therapies available, focusing on those with established biochemical mechanisms and evidence of efficacy.