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Gold nanomaterials for biochemical sensing 用于生化传感的金纳米材料
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-08-03 DOI: 10.1007/s13404-022-00318-8
Liping Tu

Abstract

Gold nanomaterials have received much attention in sensing due to their unique optical and electronic properties. This article briefly summarized the synthesis, property of gold nanomaterials before focusing on their application to sensing. The synthesis of three major types of gold nanomaterials is discussed: gold nanoclusters, which are synthesized by templated method, and gold nanoparticles, which are synthesized by chemical reduction methods, and gold nanorods, which are synthesized by the seed-mediated method. More methods affecting nano properties are discussed. Properties of these gold nanomaterials are usually connected to their application. Their fluorescent, photoluminescent, chemiluminescent, electrochemiluminescent, and catalytic properties are what give them potential in sensing. For the further application of gold-based nanomaterials in sense, the author suggests that more research needs to be done on understanding their properties and surface functionalization which provide greater selectivity and sensitivity in sense. Moreover, new detection techniques need to be developed to improve detection accuracy and reduce operational complexity.

Graphical abstract

摘要纳米金材料以其独特的光学和电子特性在传感领域受到广泛关注。本文简要介绍了金纳米材料的合成、性质及其在传感领域的应用。讨论了三种主要金纳米材料的合成方法:模板法合成的金纳米团簇、化学还原法合成的金纳米粒子和种子介导法合成的金纳米棒。讨论了影响纳米性能的其他方法。这些金纳米材料的性质通常与其应用有关。它们的荧光、光致发光、化学发光、电化学发光和催化性质使它们在传感方面具有潜力。对于金基纳米材料在意义上的进一步应用,作者建议在了解其性质和表面功能化方面做更多的研究,以提供更大的选择性和灵敏度。此外,需要开发新的检测技术来提高检测精度和降低操作复杂性。图形抽象
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引用次数: 3
Aurocyanide adsorption onto granular activated carbon impregnated with SDS anionic surfactant 浸渍SDS阴离子表面活性剂颗粒活性炭对氰化物的吸附
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-06-25 DOI: 10.1007/s13404-022-00314-y
C. Vargas, P. Navarro, E. Mejía, P. Hernández

The impregnation of granular activated carbon with the anionic surfactant sodium dodecylsulfate (SDS) was studied and the influence on aurocyanide adsorption was evaluated. Thermodynamic and kinetic parameters were also determined. The impregnation of activated carbon with SDS improves gold adsorption by 10%, showing a cleansing effect on the carbon surface which was displayed in a higher specific surface area. Specific pore volume and average pore diameter did not undergo important changes. Increasing the temperature decreases gold adsorption on modified carbon. The standard enthalpy of adsorption and the activation energy were calculated, getting values of − 41.3 kJ/mol and 15.0 kJ/mol, respectively.

研究了负离子表面活性剂十二烷基硫酸钠(SDS)对颗粒活性炭的浸渍,并对其吸附氰化物的影响进行了评价。测定了热力学和动力学参数。SDS浸渍活性炭后,活性炭对金的吸附能力提高了10%,对活性炭表面有清洁作用,比表面积增大。比孔容和平均孔径变化不大。温度升高会降低金在改性碳上的吸附。计算了标准吸附焓和活化能,分别为- 41.3 kJ/mol和15.0 kJ/mol。
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引用次数: 2
Gold nanocluster triggering near-infrared photocatalytic oxidations 金纳米团簇引发近红外光催化氧化
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-04-27 DOI: 10.1007/s13404-022-00315-x
Man-Bo Li

Abstract

Developing efficient near-infrared photocatalyst for organic transformations is a long but challenging goal. In a recent paper in Journal of the American Chemical Society, Shuxin Wang, Jun Xuan, Manzhou Zhu and co-workers explored the gold nanocluster-triggered near-infrared photocatalytic oxidative functionalization with high efficiency. This work cultivates a new land for the application of metal nanocluster as well as near-infrared photocatalysis.

摘要开发高效的近红外光催化剂用于有机转化是一个长期而具有挑战性的目标。在最近发表于《美国化学会杂志》上的一篇论文中,王淑欣、宣军、朱曼洲等人探索了金纳米团簇触发的近红外光催化氧化功能化的高效方法。本研究为金属纳米团簇的应用以及近红外光催化开辟了新的领域。
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引用次数: 1
Phytoremediation ability of Helichrysum arenarium plant for Au and Ag: case study at Demirören village (Gümüşhane, Turkey) 蜡菊(helichryum arenarium)植物对金、银的修复能力:以土耳其Demirören村(g<s:1> m<e:1> hane)为例
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-04-12 DOI: 10.1007/s13404-022-00313-z
Alaaddin Vural, Semaneh Safari

Abstract

It was investigated ability of Helichrysum arenarium plant, in phytoextraction, phytostabilization, and phytoremediation in this study. Soil and plant samples were collected from the Demirören alteration site which has the potential of gold mineralization and analyzed for gold and silver. When the results of the analysis were evaluated, it was determined that the gold and silver contents in the soil did not show compatibility with the gold and silver contents of the plants grown at the same point. It was concluded that the high gold and silver concentrations in the plants are related to the hydrothermal alteration and weathering at the point where the plants grow. For investigation of phytoremediation ability of the plant, translocation factor (TF), bio-concentration factor (BCF), and bioaccumulation factor (BAF) were calculated. The values of TF, BAF, and BCF for Ag are equal 0.33, 0.043, and 0.13 and for Au are equal 2.04, 0.59, and 0.29, respectively. So, obtained data show that Helichrysum arenarium is not appropriate for phytoextraction and phytostabilization of gold and silver in this case, but H. arenarium can be used in phyto-mining and for biogeochemical exploration of gold. Considering that the gold and silver concentrations in the developed soil in the study area are low concentrations, it is predicted that a similar study will yield satisfactory-interesting results when it is made in plants grown on the gold mineralization/enrichment areas.

摘要研究了蜡菊在植物提取、稳定和修复等方面的作用。在具有金矿化潜力的Demirören蚀变点采集土壤和植物样品,进行了金银分析。当对分析结果进行评价时,确定土壤中的金银含量与同一地点生长的植物的金银含量不表现出相容性。结果表明,植物中金、银的高含量与植物生长部位的热液蚀变和风化作用有关。为了研究植物修复能力,计算了植物转运因子(translocation factor, TF)、生物富集因子(bioconcentration factor, BCF)和生物积累因子(bioaccumulation factor, BAF)。Ag的TF、BAF和BCF分别为0.33、0.043和0.13,Au的TF、BAF和BCF分别为2.04、0.59和0.29。由此可见,在这种情况下,砂蜡菊不适合用于植物提取和植物稳定金银,但砂蜡菊可用于植物采矿和金的生物地球化学找矿。考虑到研究区发育土壤中金、银的浓度较低,预测在金矿化/富集区生长的植物上进行类似的研究将会得到令人满意的结果。
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引用次数: 4
Obituary for Masatake Haruta (1947–2022) 春田正武的讣告(1947–2022)
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-03-19 DOI: 10.1007/s13404-022-00312-0
Toru Murayama, Tamao Ishida
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引用次数: 0
Assessment of microRNA-21 using gold nanoparticle-DNA conjugates based on colorimetric and fluorescent detection 基于比色和荧光检测的金纳米颗粒- dna偶联物对microRNA-21的评价
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-03-15 DOI: 10.1007/s13404-022-00308-w
Nasrin Zare, Razieh Ghasemi, Laleh Rafiee, Shaghayegh Haghjooy Javanmard

The miR-21 detection is essential for the accurate and early diagnosis or prognosis of most diseases. In the current study, the miR-21 detection method was performed based on the exploitation of the simple colorimetric biosensor due to the unique surface plasmon resonance (SPR) absorption of gold nanoparticles. AuNPs were functionalized with the specific DNA probes on the gold surface by Au-SH bond. Two strategies are proposed to detect the miR-21. In the first strategy, probes (DNA1 and DNA2) were complementary to the sequence of the miR-21. When miR-21 is introduced, the hybridization reaction is triggered between the golden nanoparticles- (GNP)-DNA conjugates and targets, resulting in changes in SPR absorption band and macroscopic color of the AuNPs solution. In the second strategy, we used a fluorescence sequence (DNA3-FAM), which was complimentary of DNA1. The DNA3-FAM was released after hybridization of miR-21 with DNA1 and DNA2. The free DNA3-FAM sequences in plate wells containing 1% agarose gel were assessed by fluorescent microscope. The combination of two strategies and conventional equipment such as UV–Vis spectrometers and fluorescent microscopes could be useful in detecting the desired miRNAs (miR-21).

miR-21的检测对于大多数疾病的准确和早期诊断或预后至关重要。在本研究中,由于金纳米颗粒独特的表面等离子体共振(SPR)吸收,基于简单比色生物传感器的开发,进行了miR-21检测方法。AuNPs通过Au-SH键与特定的DNA探针在金表面功能化。我们提出了两种检测miR-21的策略。在第一种策略中,探针(DNA1和DNA2)与miR-21的序列互补。引入miR-21后,金纳米颗粒- (GNP)- dna偶联物与靶标之间发生杂交反应,导致AuNPs溶液的SPR吸收带和宏观颜色发生变化。在第二种策略中,我们使用了与DNA1互补的荧光序列(DNA3-FAM)。miR-21与DNA1和DNA2杂交后释放DNA3-FAM。用荧光显微镜观察含有1%琼脂糖凝胶的板孔中游离DNA3-FAM序列。两种策略和常规设备(如紫外可见光谱仪和荧光显微镜)的结合可能有助于检测所需的mirna (miR-21)。
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引用次数: 3
Formation of gold hollow spheres by rapid heating–cooling process 快速加热-冷却工艺制备金空心球
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-03-08 DOI: 10.1007/s13404-022-00311-1
Lin Zhang, Jianjun Zhang, Quan Zheng, Ying Xu, Xinli Kou, Tao Li

Although gold hollow spheres show unique advantages in fields like catalysis, the available synthesis strategies have low atom and economic efficiency. In this paper, Au hollow spheres were produced by combining simple wet chemical method and rapid heating–cooling process, in which rapid temperature rise caused Au evaporation and rapid cooling froze gold “bubbles.” The control experiments confirmed the presence of supports which limit the growth and sintering of Au nanoparticles to some extent, and slower heating rate inhibits the hollowing of gold sphere. This work provides a new strategy for the rapid and facile synthesis of Au hollow spheres, offering a wide range of possibilities for energy storage and biosensing applications.

虽然金空心球在催化等领域显示出独特的优势,但现有的合成策略原子效率低,经济效率低。本文采用简单湿化学法和快速加热冷却相结合的方法制备了金空心球,其中快速升温使金蒸发,快速冷却使金“气泡”冻结。对照实验证实,载体的存在在一定程度上限制了金纳米颗粒的生长和烧结,较慢的升温速率抑制了金球的空心化。这项工作为快速简便地合成金空心球提供了一种新的策略,为能量存储和生物传感应用提供了广泛的可能性。
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引用次数: 1
Development of gold, silver, and iron nanoparticles using isolated berberine: its characterization and antimicrobial and cytotoxic activities against COLO320DM and Hela cells 利用分离的小檗碱制备金、银和铁纳米颗粒:其表征及其对COLO320DM和Hela细胞的抗菌和细胞毒性活性
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-02-18 DOI: 10.1007/s13404-022-00309-9
Mangesh A. Bhutkar, Dheeraj S. Randive, Somnath D. Bhinge, Ganesh H. Wadkar, Sachin S. Todkar, Kiran P. Shejawal

Abstract

The current report discloses the development of gold, silver, and iron nanoparticles using berberine by green synthesis and its evaluation for antimicrobial activity and in vitro cytotoxicity against colon cancer and human cervical cancer cells. The prepared nanoparticles were characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction analysis. The characterization of results of the prepared nanoparticles satisfied the distinctive properties of the potent nanodrug. The antimicrobial potential was exhibited by all the prepared nanoparticles against the selected microbial strains. The zone of inhibition (mm) exhibited by gold nanoparticles biosynthesized using berberine (BAuNPs) was 15.66 ± 0.47 mm against Pseudomonas aeruginosa, 15.0 ± 1.41 against Escherichia coli, and 15.33 ± 1.24 mm against Staphylococcus aureus. The cytotoxicity study exhibited promising results as compared to pure berberine. The results of the MTT assay of gold nanoparticles against COLO320DM exhibited 92.27 ± 0.14% inhibition, whereas in the case of the SRB assay, it revealed 89.72 ± 0.29% inhibition as compared to other nanoparticles and pure berberine. For Hela cell lines, in the case of the MTT assay, BAuNPs exhibited 92.13 ± 0.64% inhibition while in the SRB assay, it revealed 85.56 ± 0.39% inhibition. The results of the Trypan blue assay revealed that BAuNPs showed 76.54 ± 1.00% inhibition against the COLO320DM cell line, whereas in the case of Hela cell lines, 78.03 ± 1.47% inhibition was observed. The effect exhibited by BAuNPs may be attributed to increased production of reactive oxygen species by treated carcinoma cells that results in oxidation of vital constituents which ultimately causes death of the cell. Thus, these in vitro results demonstrate the promising therapeutic applications of the BAuNPs in nanomedicine.

摘要本文介绍了利用小檗碱绿色合成金、银、铁纳米粒子的研究进展及其对结肠癌和人宫颈癌细胞的抑菌活性和体外细胞毒性评价。采用傅里叶变换红外光谱(FT-IR)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和x射线衍射分析对制备的纳米颗粒进行了表征。制备的纳米颗粒的表征结果符合强效纳米药物的独特性质。所制备的纳米颗粒对所选的微生物菌株均表现出抗菌潜力。小檗碱合成的金纳米颗粒对铜绿假单胞菌的抑制区(mm)为15.66±0.47 mm,对大肠杆菌的抑制区为15.0±1.41 mm,对金黄色葡萄球菌的抑制区为15.33±1.24 mm。与纯小檗碱相比,细胞毒性研究显示出有希望的结果。在MTT实验中,金纳米颗粒对COLO320DM的抑制率为92.27±0.14%,而在SRB实验中,与其他纳米颗粒和纯小檗碱相比,金纳米颗粒的抑制率为89.72±0.29%。对于Hela细胞系,在MTT试验中,BAuNPs的抑制率为92.13±0.64%,而在SRB试验中,BAuNPs的抑制率为85.56±0.39%。台普兰蓝实验结果显示,BAuNPs对COLO320DM细胞株的抑制作用为76.54±1.00%,而对Hela细胞株的抑制作用为78.03±1.47%。BAuNPs所表现出的效果可能归因于经处理的癌细胞活性氧的产生增加,导致重要成分氧化,最终导致细胞死亡。因此,这些体外实验结果证明了BAuNPs在纳米医学中的治疗应用前景。
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引用次数: 4
Comparison of polyampholyte derivative of chitosan with bisphthalimides of low molecular weight in the green synthesis of Au nanoparticles 壳聚糖聚两性衍生物与低分子量双酞亚胺绿色合成金纳米颗粒的比较
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-02-15 DOI: 10.1007/s13404-022-00310-2
Martín Caldera Villalobos, Miguel Ángel García Castro, Jesús García Serrano, Ana M. Herrera González

Abstract

This work reports the chemical modification of chitosan with phthalimide moieties and the synthesis of two bisphthalimides (BPIs) with low molecular weight useful in the green synthesis of Au nanoparticles. The polyampholyte derivative of chitosan was obtained in water while the two BPIs, N,N´-(1,3-phenylene)bis(phthalimide-5-carboxylic acid) (BPI-1) and N,N´-(1,4-phenylene)bis(phthalimide-5-carboxylic acid) (BPI-2) were obtained by solid state reaction without the use of organic solvents. The polyampholyte and two BPIs were soluble in water; therefore, they were used in the green synthesis of Au nanoparticles. The characterization of three compounds was made by FTIR and 1H NMR. TEM and UV–Vis results revealed that the compounds can reduce gold ions and stabilize Au nanoparticles in the colloidal solutions. The shape of the Au nanoparticles was quasi-spherical, while the average size of Au nanoparticles stabilized with the compounds BPI-1 and BPI-2 was 3 and 12 nm, respectively. Thus, with BPI-1 was obtained Au nanoparticles with lower size than BPI-2. Finally, the average size of nanoparticles stabilized with the polyampholyte was 10 nm. However, the faster reaction to obtain nanoparticles was with the polyampholyte derivative of chitosan (5 min), due to high quantity of oxidizable groups found in the polymer structure by its high molecular weight.

摘要本文报道了用邻苯二甲酸亚胺对壳聚糖进行化学改性,合成了两种低分子量的双苯二甲酸亚胺(bpi),可用于绿色合成金纳米颗粒。在水中得到壳聚糖的多两性衍生物,在不使用有机溶剂的情况下,通过固相反应得到N,N´-(1,3-苯基)双(邻苯二胺-5-羧酸)(BPI-1)和N,N´-(1,4-苯基)双(邻苯二胺-5-羧酸)(BPI-2)。聚两性聚合物和两种双酚类化合物均可溶于水;因此,它们被用于绿色合成金纳米颗粒。用FTIR和1H NMR对三个化合物进行了表征。TEM和UV-Vis结果表明,该化合物在胶体溶液中具有还原金离子和稳定金纳米粒子的作用。得到的Au纳米颗粒呈准球形,而BPI-1和BPI-2稳定的Au纳米颗粒的平均尺寸分别为3 nm和12 nm。因此,用BPI-1得到的金纳米颗粒比BPI-2小。最后,聚两性电解质稳定的纳米颗粒平均尺寸为10 nm。然而,由于高分子量的聚合物结构中含有大量的可氧化基团,壳聚糖的多两性衍生物反应速度更快(5分钟)。
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引用次数: 1
Synergic effect of paclitaxel and cisplatin associated with gold nanoparticles on HeLa cervical cells 紫杉醇和顺铂联合金纳米颗粒对HeLa宫颈细胞的协同作用
IF 2.2 4区 工程技术 Q2 Chemistry Pub Date : 2022-01-22 DOI: 10.1007/s13404-021-00305-5
Maria Laura Rodrigues Uggioni, Paulo Emilio Feuser, Jonathann Corrêa Possato, Maria Eduarda de Melo, Ellen De Pieri, Rodrigo Cercena, Alexandre Gonçalves Dal Bó, Maria Inês da Rosa, Ricardo Andrez Machado-de-Ávila

Abstract  

The combination of two or more chemotherapy drugs and nanotechnology has emerged as an effective strategy in the fight against cancer. Paclitaxel (PTX) and cisplatin show improved cytotoxic effects on being used together in the chemotherapy of various cancer types, than when used individually. However, these chemotherapy drugs have been shown to have numerous toxic effects in cancer patients. Therefore, the aim of this study was to evaluate the cytotoxicity of PTX and cisplatin associated with gold nanoparticles (AuNps) on HeLa cells containing multiple copies of human papillomavirus 18. AuNps were successfully synthesized with a mean size of 20 to 61 nm, polydispersity index ≥ 0.3, and negative surface charge. Together, PTX and cisplatin associated with AuNps showed a higher cytotoxic effect on HeLa cells than free drugs. The combination of PTX and cisplatin with AuNps potentiated their cytotoxic effects, inducing synergism between the treatments, resulting in HeLa cell death by apoptosis.

Graphical abstract

两种或多种化疗药物与纳米技术的结合已成为对抗癌症的有效策略。紫杉醇(PTX)和顺铂在各种癌症类型的化疗中联合使用比单独使用时显示出更好的细胞毒性作用。然而,这些化疗药物已被证明对癌症患者有许多毒性作用。因此,本研究的目的是评估PTX和顺铂与金纳米颗粒(AuNps)相关对含有人乳头瘤病毒18多拷贝的HeLa细胞的细胞毒性。成功合成的AuNps平均尺寸为20 ~ 61 nm,多分散性指数≥0.3,表面带负电荷。总之,PTX和顺铂与AuNps相关,对HeLa细胞的细胞毒性作用高于游离药物。PTX和顺铂联合AuNps增强了它们的细胞毒作用,诱导了治疗之间的协同作用,导致HeLa细胞凋亡死亡。图形抽象
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引用次数: 4
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