Pub Date : 2026-01-16DOI: 10.1186/s12964-026-02676-8
Jill P Smith, Mahdis Mohit, Joi Kenner, Ajay Nathan, Jack Drda, Martha D Gay, Hong Cao, Wenqiang Chen, Alison Gomeiz, Elisa Baldelli, Wenyu Dou, Hong-Bin Fang, Narayan Shivapurkar, James Davis, Qi Wei, Abdellah Akhrif, Mariaelena Pierobon
{"title":"Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth.","authors":"Jill P Smith, Mahdis Mohit, Joi Kenner, Ajay Nathan, Jack Drda, Martha D Gay, Hong Cao, Wenqiang Chen, Alison Gomeiz, Elisa Baldelli, Wenyu Dou, Hong-Bin Fang, Narayan Shivapurkar, James Davis, Qi Wei, Abdellah Akhrif, Mariaelena Pierobon","doi":"10.1186/s12964-026-02676-8","DOIUrl":"10.1186/s12964-026-02676-8","url":null,"abstract":"","PeriodicalId":55268,"journal":{"name":"Cell Communication and Signaling","volume":" ","pages":"71"},"PeriodicalIF":8.2,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12859874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1186/s12964-026-02660-2
Sarah Jang, Jae-Yeon Jeong, Won-Ki Huh
{"title":"Activation of the pituitary adenylate cyclase-activating polypeptide type I receptor promotes neuroblastoma proliferation and migration through distinct G protein pathways.","authors":"Sarah Jang, Jae-Yeon Jeong, Won-Ki Huh","doi":"10.1186/s12964-026-02660-2","DOIUrl":"10.1186/s12964-026-02660-2","url":null,"abstract":"","PeriodicalId":55268,"journal":{"name":"Cell Communication and Signaling","volume":" ","pages":"105"},"PeriodicalIF":8.2,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1186/s12964-025-02635-9
Sheetal Parida, Deeptashree Nandi, Deepak Verma, Mingyang Yi, Ashutosh Yende, Jessica Queen, Kathleen L Gabrielson, Cynthia L Sears, Dipali Sharma
The intricate relationship between microbiota and breast cancer presents an additional risk factor that can have a profound impact on disease progression. Focusing on dysbiosis, our metagenomic analysis shows overabundance of an oral pathogenic microbe F. nucleatum and co-habitation of associated biofilm forming oral microbes in cancerous breast. Mammary gland colonization with F. nucleatum results in the development of metaplastic lesions accompanied with inflammation, DNA damage and hyper-proliferation in healthy mice. Exhibiting the impact of circulating F. nucleatum introduced via hematogenous route, breast tumor bearing mice show accelerated tumor growth and metastatic progression. Increased proliferation, migration, self-renewal and chemoresistance in breast cancer cells as well as non-tumorigenic breast epithelial cells bearing pathogenic BRCA1 mutation is observed upon F. nucleatum exposure which is internalized by the cells in a Gal-GalNAc dependent manner. Of interest, cells harboring BRCA1 mutations exhibit greater cell surface accumulation of Gal-GalNAc sugar residue. This work sheds light on the oncogenic impact of a pro-carcinogenic oral bacterium, F. nucleatum, on normal mammary epithelium and breast cancer, implicates the impairment of DNA damage and repair pathways as its functional mediators, and proposes the concept of increased vulnerability of BRCA1 mutant breast cancer cells owing to their preferential internalization of F. nucleatum.
{"title":"A pro-carcinogenic oral microbe internalized by breast cancer cells promotes mammary tumorigenesis.","authors":"Sheetal Parida, Deeptashree Nandi, Deepak Verma, Mingyang Yi, Ashutosh Yende, Jessica Queen, Kathleen L Gabrielson, Cynthia L Sears, Dipali Sharma","doi":"10.1186/s12964-025-02635-9","DOIUrl":"https://doi.org/10.1186/s12964-025-02635-9","url":null,"abstract":"<p><p>The intricate relationship between microbiota and breast cancer presents an additional risk factor that can have a profound impact on disease progression. Focusing on dysbiosis, our metagenomic analysis shows overabundance of an oral pathogenic microbe F. nucleatum and co-habitation of associated biofilm forming oral microbes in cancerous breast. Mammary gland colonization with F. nucleatum results in the development of metaplastic lesions accompanied with inflammation, DNA damage and hyper-proliferation in healthy mice. Exhibiting the impact of circulating F. nucleatum introduced via hematogenous route, breast tumor bearing mice show accelerated tumor growth and metastatic progression. Increased proliferation, migration, self-renewal and chemoresistance in breast cancer cells as well as non-tumorigenic breast epithelial cells bearing pathogenic BRCA1 mutation is observed upon F. nucleatum exposure which is internalized by the cells in a Gal-GalNAc dependent manner. Of interest, cells harboring BRCA1 mutations exhibit greater cell surface accumulation of Gal-GalNAc sugar residue. This work sheds light on the oncogenic impact of a pro-carcinogenic oral bacterium, F. nucleatum, on normal mammary epithelium and breast cancer, implicates the impairment of DNA damage and repair pathways as its functional mediators, and proposes the concept of increased vulnerability of BRCA1 mutant breast cancer cells owing to their preferential internalization of F. nucleatum.</p>","PeriodicalId":55268,"journal":{"name":"Cell Communication and Signaling","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1186/s12964-026-02651-3
Amanda Lindberg, Louise Hellberg, Anaïs Grandon, Hui Yu, Viktoria Thurfjell, Erik Wåhlén, Neda Hekmati, Max Backman, Axel Cederholm, Artur Mezheyeuski, Anna Klemm, Johan Botling, Agata Zieba Wicher, Patrick Micke, Carina Strell
{"title":"In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC.","authors":"Amanda Lindberg, Louise Hellberg, Anaïs Grandon, Hui Yu, Viktoria Thurfjell, Erik Wåhlén, Neda Hekmati, Max Backman, Axel Cederholm, Artur Mezheyeuski, Anna Klemm, Johan Botling, Agata Zieba Wicher, Patrick Micke, Carina Strell","doi":"10.1186/s12964-026-02651-3","DOIUrl":"10.1186/s12964-026-02651-3","url":null,"abstract":"","PeriodicalId":55268,"journal":{"name":"Cell Communication and Signaling","volume":" ","pages":"55"},"PeriodicalIF":8.2,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1186/s12964-026-02655-z
Cristina Trujillo-Del Río, Seda Koyuncu, Julia Tortajada-Pérez, Mar Collado-Pérez, Ana Pilar Gómez-Escribano, Carlos Mora, Christian Neri, Agustín Lahoz, Marta Roca, José María Millán, Yolanda Sanz, David Vilchez, Andrea Del Valle Carranza, Rafael P Vázquez-Manrique
{"title":"SIR-2.3/SIRT4 loss enhances proteostasis and neuronal resilience via AMPK-induced autophagy in Huntington's disease models.","authors":"Cristina Trujillo-Del Río, Seda Koyuncu, Julia Tortajada-Pérez, Mar Collado-Pérez, Ana Pilar Gómez-Escribano, Carlos Mora, Christian Neri, Agustín Lahoz, Marta Roca, José María Millán, Yolanda Sanz, David Vilchez, Andrea Del Valle Carranza, Rafael P Vázquez-Manrique","doi":"10.1186/s12964-026-02655-z","DOIUrl":"10.1186/s12964-026-02655-z","url":null,"abstract":"","PeriodicalId":55268,"journal":{"name":"Cell Communication and Signaling","volume":" ","pages":"109"},"PeriodicalIF":8.2,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1186/s12964-025-02636-8
Salwador Cyranowski, Małgorzata Zawadzka, Mitrajit Ghosh, Bartosz Wojtas, Anna R Malik, Katarzyna Poleszak, Kacper Waśniewski, Szymon Baluszek, Julian Swatler, Kamil Wojnicki, Bartłomiej Gielniewski, Beata Kaza, Agata Klejman, Hanna Łukasik, Bozena Kaminska
{"title":"Chitinase-3-like protein 1 depletion in glioma cells alters tumor microenvironment and normalizes neovasculature in human glioma xenografts.","authors":"Salwador Cyranowski, Małgorzata Zawadzka, Mitrajit Ghosh, Bartosz Wojtas, Anna R Malik, Katarzyna Poleszak, Kacper Waśniewski, Szymon Baluszek, Julian Swatler, Kamil Wojnicki, Bartłomiej Gielniewski, Beata Kaza, Agata Klejman, Hanna Łukasik, Bozena Kaminska","doi":"10.1186/s12964-025-02636-8","DOIUrl":"10.1186/s12964-025-02636-8","url":null,"abstract":"","PeriodicalId":55268,"journal":{"name":"Cell Communication and Signaling","volume":" ","pages":"103"},"PeriodicalIF":8.2,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1186/s12964-025-02592-3
Spoorthy Gowda, Arun Kumar, Ulrike Topf
{"title":"Unlocking neuronal health: leveraging C. elegans for drug repurposing studies.","authors":"Spoorthy Gowda, Arun Kumar, Ulrike Topf","doi":"10.1186/s12964-025-02592-3","DOIUrl":"10.1186/s12964-025-02592-3","url":null,"abstract":"","PeriodicalId":55268,"journal":{"name":"Cell Communication and Signaling","volume":" ","pages":"101"},"PeriodicalIF":8.2,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号