Ameloblastoma is a locally invasive epithelial tumor of odontogenic origin comprising 1% or less of the cystic lesions and tumors arising in the jaws. It is a lesion most commonly seen in the molar region of the mandibular ramus. Ameloblastomas can be both benign and malignant and this can be differentiated by certain unique morphological features. In the older histology nomenclature, the term “adamantinoma” was used instead of ameloblastoma. The chances of recurrence can be high or low depending upon the surgical management. Curettages are associated with high recurrence rates while wide local excision tends to reduce recurrences.
{"title":"Ameloblastoma, a tumor with an infamous notoriety for recurrence","authors":"M. Jagtap, S. Shukla, D. Nair","doi":"10.4103/jss.jss_115_22","DOIUrl":"https://doi.org/10.4103/jss.jss_115_22","url":null,"abstract":"Ameloblastoma is a locally invasive epithelial tumor of odontogenic origin comprising 1% or less of the cystic lesions and tumors arising in the jaws. It is a lesion most commonly seen in the molar region of the mandibular ramus. Ameloblastomas can be both benign and malignant and this can be differentiated by certain unique morphological features. In the older histology nomenclature, the term “adamantinoma” was used instead of ameloblastoma. The chances of recurrence can be high or low depending upon the surgical management. Curettages are associated with high recurrence rates while wide local excision tends to reduce recurrences.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41918793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
With the advancements in science and the field of medicine, it has become a reality that people are living longer in contrast to the earlier trends of life expectancy. The current review was carried out to explore the integration of geriatric competencies in the medical education curriculum. An extensive search of all materials related to the topic was carried out in the PubMed search engine, and a total of five articles were selected based upon the suitability with the current review objectives and analyzed. As it is quite obvious that in the years to come all the medical doctors will encounter a large number of elderly patients with physical, psychological, and other social concerns, it becomes indispensable to expose them to different geriatric competencies during the undergraduate period of training. We must also accept that elderly population requires a different approach and the better and long-term approach will be to expose the undergraduate medical students in this domain and prepare them for their future clinical practice. This integration into the existing curriculum has to start with the formulation of geriatric competencies that need to be covered in the undergraduation period followed by curriculum mapping. In conclusion, regardless of the rise in the number of the elderly, the medical education imparted to undergraduate medical students lacks alignment. This calls for the need to expose the medical students to different learning experiences in geriatrics and prepare them to not only meet the specific needs of the elderly but also address the concern of shortage of geriatricians.
{"title":"Integrating geriatric competencies in the undergraduate medical education","authors":"S. Shrivastava, P. Shrivastava","doi":"10.4103/jss.jss_42_21","DOIUrl":"https://doi.org/10.4103/jss.jss_42_21","url":null,"abstract":"With the advancements in science and the field of medicine, it has become a reality that people are living longer in contrast to the earlier trends of life expectancy. The current review was carried out to explore the integration of geriatric competencies in the medical education curriculum. An extensive search of all materials related to the topic was carried out in the PubMed search engine, and a total of five articles were selected based upon the suitability with the current review objectives and analyzed. As it is quite obvious that in the years to come all the medical doctors will encounter a large number of elderly patients with physical, psychological, and other social concerns, it becomes indispensable to expose them to different geriatric competencies during the undergraduate period of training. We must also accept that elderly population requires a different approach and the better and long-term approach will be to expose the undergraduate medical students in this domain and prepare them for their future clinical practice. This integration into the existing curriculum has to start with the formulation of geriatric competencies that need to be covered in the undergraduation period followed by curriculum mapping. In conclusion, regardless of the rise in the number of the elderly, the medical education imparted to undergraduate medical students lacks alignment. This calls for the need to expose the medical students to different learning experiences in geriatrics and prepare them to not only meet the specific needs of the elderly but also address the concern of shortage of geriatricians.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42480873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coronavirus disease 2019 (COVID-19) pandemic is currently evolving and associated with more complications with invasive fungal infection like mucormycosis. Classically, uncontrolled diabetes mellitus (DM) and other immunosuppressive conditions like corticosteroid therapy are known risk factors for causing mucormycosis in COVID-19 patients. Mucormycosis is an invasive fungal infection which rapidly spread to the orbit and brain from the nasal cavity and paranasal sinuses. Mucormycosis in COVID-19 is a fatal to the patient. There is possibility of COVID-19 as a trigger factor for diabetic ketoacidosis which predisposes to invasive fungal infections such as mucormycosis. Patients with poorly controlled DM and immunocompromised conditions increase the risk for development of COVID-19 infections in COVID-19 patients. During the current COVID-19 pandemic, a myriad of clinical manifestations and complications are emerged. Rhino-orbital-cerebral mucormycosis is a fatal clinical entity associated with COVID-19 infections resulting in higher morbidity and mortality. The treatment includes both medical and surgical interventions. It requires early and adequate treatment with amphotericin B and surgical debridement and control of risk factors. A multidisciplinary approach by otorhinolaryngologists, ophthalmologists, neurologists, and dentists is successful for treatment of COVID-19 patients with mucormycosis in the head-and-neck region. Identification of the risk factors and early preventive measures will minimize the incidence of life-threatening mucormycosis in the head-and-neck area of COVID-19 patients.
{"title":"Coronavirus disease 2019-associated mucormycosis of the head-and-neck area: A new rise of dreaded black fungus in the current pandemic","authors":"S. Swain, P. Jena","doi":"10.4103/jss.jss_56_21","DOIUrl":"https://doi.org/10.4103/jss.jss_56_21","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) pandemic is currently evolving and associated with more complications with invasive fungal infection like mucormycosis. Classically, uncontrolled diabetes mellitus (DM) and other immunosuppressive conditions like corticosteroid therapy are known risk factors for causing mucormycosis in COVID-19 patients. Mucormycosis is an invasive fungal infection which rapidly spread to the orbit and brain from the nasal cavity and paranasal sinuses. Mucormycosis in COVID-19 is a fatal to the patient. There is possibility of COVID-19 as a trigger factor for diabetic ketoacidosis which predisposes to invasive fungal infections such as mucormycosis. Patients with poorly controlled DM and immunocompromised conditions increase the risk for development of COVID-19 infections in COVID-19 patients. During the current COVID-19 pandemic, a myriad of clinical manifestations and complications are emerged. Rhino-orbital-cerebral mucormycosis is a fatal clinical entity associated with COVID-19 infections resulting in higher morbidity and mortality. The treatment includes both medical and surgical interventions. It requires early and adequate treatment with amphotericin B and surgical debridement and control of risk factors. A multidisciplinary approach by otorhinolaryngologists, ophthalmologists, neurologists, and dentists is successful for treatment of COVID-19 patients with mucormycosis in the head-and-neck region. Identification of the risk factors and early preventive measures will minimize the incidence of life-threatening mucormycosis in the head-and-neck area of COVID-19 patients.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45656167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fotis G. Souslian, Tariq Janjua, L. Moscote-Salazar
Severe subdural empyema (SDE) involving both the brain and spinal cord can be a life-threatening condition if not treated properly. We describe a malnourished patient with extensive spinal and intracranial SDE, whose poor prognosis prompted palliative care consultation. Surgical options were not possible. However, following maximal medical therapy, the patient's condition resolved completely in 1 year. This case highlights the important relationship between neurocritical care medical management and infection when surgical options are not possible.
{"title":"Maximal medical therapy in extensive subdural empyema of the brain and spinal cord","authors":"Fotis G. Souslian, Tariq Janjua, L. Moscote-Salazar","doi":"10.4103/jss.jss_116_22","DOIUrl":"https://doi.org/10.4103/jss.jss_116_22","url":null,"abstract":"Severe subdural empyema (SDE) involving both the brain and spinal cord can be a life-threatening condition if not treated properly. We describe a malnourished patient with extensive spinal and intracranial SDE, whose poor prognosis prompted palliative care consultation. Surgical options were not possible. However, following maximal medical therapy, the patient's condition resolved completely in 1 year. This case highlights the important relationship between neurocritical care medical management and infection when surgical options are not possible.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48439468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mental health has been acknowledged an integral component of maintenance of optimal health of individuals and communities. The purpose of the current review was to explore the teaching practices for mental health competencies and strengthen the same in undergraduate teaching period. An extensive search of all materials related to the topic was carried out in the PubMed search engine and a total of 19 articles were selected based on their suitability with the current review objectives. Amid the shortage of trained psychiatrists, it becomes an indispensable need that undergraduate medical students are trained in specific competencies in the subject so that they are empowered to manage basic psychiatric illnesses, especially at the primary level of health care. If we can train our medical undergraduate students, it will turn out to be the most cost-effective and feasible approach to meet the needs of the rural and remote sections of the society. As the imparted mental health training is grossly inadequate or incomplete, it is a must that we take specific steps to improve the existing scenario. In conclusion, psychiatry is an essential and integral component of medical training in the undergraduation period. However, the subject lacks the desired attention under the present circumstances, and thus there is an indispensable need to improve the training and assessment of psychiatric competencies so that students become competent in discharging their future clinical roles.
{"title":"Prioritizing training of undergraduate medical students in mental health competencies","authors":"S. Shrivastava, P. Shrivastava","doi":"10.4103/jss.jss_62_21","DOIUrl":"https://doi.org/10.4103/jss.jss_62_21","url":null,"abstract":"Mental health has been acknowledged an integral component of maintenance of optimal health of individuals and communities. The purpose of the current review was to explore the teaching practices for mental health competencies and strengthen the same in undergraduate teaching period. An extensive search of all materials related to the topic was carried out in the PubMed search engine and a total of 19 articles were selected based on their suitability with the current review objectives. Amid the shortage of trained psychiatrists, it becomes an indispensable need that undergraduate medical students are trained in specific competencies in the subject so that they are empowered to manage basic psychiatric illnesses, especially at the primary level of health care. If we can train our medical undergraduate students, it will turn out to be the most cost-effective and feasible approach to meet the needs of the rural and remote sections of the society. As the imparted mental health training is grossly inadequate or incomplete, it is a must that we take specific steps to improve the existing scenario. In conclusion, psychiatry is an essential and integral component of medical training in the undergraduation period. However, the subject lacks the desired attention under the present circumstances, and thus there is an indispensable need to improve the training and assessment of psychiatric competencies so that students become competent in discharging their future clinical roles.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48376626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyperlactatemia (excess blood lactate) is common in severely unwell individuals. Although lactate levels are routinely used to indicate insufficient tissue oxygenation, they can also be elevated by mechanisms unrelated to tissue oxygenation. Increased glycolysis may be a major cause of hyperlactatemia, especially in critically sick individuals. Despite this, elevated lactate levels have serious consequences for the morbidity and mortality of hyperlactatemia individuals. Despite the widespread use of the phrase lactic acidosis, a substantial link between lactate and pH appears only at higher lactate levels. As a result, the phrase lactate-related acidosis is more suitable. In early resuscitation, two recent studies have emphasized the necessity of monitoring lactate levels and adjusting treatment to changes in lactate levels. Structured lactate measures should be included in resuscitation protocols since lactate levels may be assessed quickly at the bedside from a variety of sources.
{"title":"Serum lactate levels in critically Ill patients: An early marker to be targeted","authors":"Ruchi Kabra, S. Acharya, S. Sushanth Kumar","doi":"10.4103/jss.jss_113_22","DOIUrl":"https://doi.org/10.4103/jss.jss_113_22","url":null,"abstract":"Hyperlactatemia (excess blood lactate) is common in severely unwell individuals. Although lactate levels are routinely used to indicate insufficient tissue oxygenation, they can also be elevated by mechanisms unrelated to tissue oxygenation. Increased glycolysis may be a major cause of hyperlactatemia, especially in critically sick individuals. Despite this, elevated lactate levels have serious consequences for the morbidity and mortality of hyperlactatemia individuals. Despite the widespread use of the phrase lactic acidosis, a substantial link between lactate and pH appears only at higher lactate levels. As a result, the phrase lactate-related acidosis is more suitable. In early resuscitation, two recent studies have emphasized the necessity of monitoring lactate levels and adjusting treatment to changes in lactate levels. Structured lactate measures should be included in resuscitation protocols since lactate levels may be assessed quickly at the bedside from a variety of sources.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47234763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jyothirmai Mallela, Tanmaya Metgud, M. Kamate, Deepti M. Kadeangadi
Context: Febrile seizures are one of the most common seizures in childhood. Febrile seizures occur in 2%–5% of children who are younger than 5 years of age. Studies have shown that iron, zinc, selenium, copper, and magnesium play a significant role in febrile seizures. This study was intended to study the relationship between iron and zinc deficiency with febrile seizures. Aim: To find the association of febrile convulsions with iron and zinc deficiency. Methodology: This hospital-based case‒control study was done in a tertiary care center in North Karnataka from January 2017 to December 2017. A total of 52 children fulfilling the inclusion criteria were included in case group. Control group contained 52 children who had fever without convulsions and matched for age, sex, and background disease with respective cases. Results: Both the groups were matched for age and gender. Majority of the children (76.92%) had a simple seizure. Cases had lower serum (Sr.) ferritin levels compared to controls with high odds ratio (OR) (25% vs. 1.92%; P < 0.001; OR = 17.00; P = 0.0075). Furthermore, cases had zinc deficiency compared to controls (84.62% vs. 25%; OR = 12.269; P < 0.001). The mean Sr. zinc levels (37.16 ± 22.07 vs. 75.75 ± 15.25 μg/dL; P < 0.001) were significantly low in cases. Conclusion and Interpretation: There was a significant association between febrile seizures with iron and zinc deficiency.
{"title":"Iron and zinc deficiency in children with febrile convulsions aged 6‒60 months ‒ A 1-year hospital-based case‒control study","authors":"Jyothirmai Mallela, Tanmaya Metgud, M. Kamate, Deepti M. Kadeangadi","doi":"10.4103/jss.jss_83_21","DOIUrl":"https://doi.org/10.4103/jss.jss_83_21","url":null,"abstract":"Context: Febrile seizures are one of the most common seizures in childhood. Febrile seizures occur in 2%–5% of children who are younger than 5 years of age. Studies have shown that iron, zinc, selenium, copper, and magnesium play a significant role in febrile seizures. This study was intended to study the relationship between iron and zinc deficiency with febrile seizures. Aim: To find the association of febrile convulsions with iron and zinc deficiency. Methodology: This hospital-based case‒control study was done in a tertiary care center in North Karnataka from January 2017 to December 2017. A total of 52 children fulfilling the inclusion criteria were included in case group. Control group contained 52 children who had fever without convulsions and matched for age, sex, and background disease with respective cases. Results: Both the groups were matched for age and gender. Majority of the children (76.92%) had a simple seizure. Cases had lower serum (Sr.) ferritin levels compared to controls with high odds ratio (OR) (25% vs. 1.92%; P < 0.001; OR = 17.00; P = 0.0075). Furthermore, cases had zinc deficiency compared to controls (84.62% vs. 25%; OR = 12.269; P < 0.001). The mean Sr. zinc levels (37.16 ± 22.07 vs. 75.75 ± 15.25 μg/dL; P < 0.001) were significantly low in cases. Conclusion and Interpretation: There was a significant association between febrile seizures with iron and zinc deficiency.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47277921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suma Dnyanesh, Sheetal V Pattanshetti, Shilpa Bhimalli, Daksha Dixit
Objectives: (1) To motivate students for self-directed learning and to enhance their communication skills. (2) To investigate jigsaw technique for its effectiveness in learning anatomy. Cooperative education is the prime aim of this teaching–learning intervention. The students rely on each other for a collective or combined learning experience. The onus of responsibility of the work done by the student and his/her team will be evaluated by the facilitator. We would like to know whether jigsaw cooperative learning would be considered as effective interventional teaching-learning measure compared to the traditional lecture method. Materials and Methods: Sixty students of first MBBS were involved in a jigsaw session to learn anatomy. The students were divided into groups of five and a total of 12 such groups were made. The study material was also divided into five topics. The students read the study material and after becoming well versed with their topic, they taught their topic to other students. The students were asked to give feedback on the session. A surprise MCQ test was also conducted between this group and a control group of students to assess their knowledge. The results of the MCQ test were statistically analyzed. Results: The students found the jigsaw session to be more engaging than traditional classes. MCQ scores were more in the study group than in the control group. Conclusion: The jigsaw technique is both an educational and enjoyable way of teaching. Due to its immense benefits, both students and teachers resolved to use this technique in the future as well.
{"title":"Jigsaw technique: An innovative teaching strategy in anatomy","authors":"Suma Dnyanesh, Sheetal V Pattanshetti, Shilpa Bhimalli, Daksha Dixit","doi":"10.4103/jss.jss_95_22","DOIUrl":"https://doi.org/10.4103/jss.jss_95_22","url":null,"abstract":"Objectives: (1) To motivate students for self-directed learning and to enhance their communication skills. (2) To investigate jigsaw technique for its effectiveness in learning anatomy. Cooperative education is the prime aim of this teaching–learning intervention. The students rely on each other for a collective or combined learning experience. The onus of responsibility of the work done by the student and his/her team will be evaluated by the facilitator. We would like to know whether jigsaw cooperative learning would be considered as effective interventional teaching-learning measure compared to the traditional lecture method. Materials and Methods: Sixty students of first MBBS were involved in a jigsaw session to learn anatomy. The students were divided into groups of five and a total of 12 such groups were made. The study material was also divided into five topics. The students read the study material and after becoming well versed with their topic, they taught their topic to other students. The students were asked to give feedback on the session. A surprise MCQ test was also conducted between this group and a control group of students to assess their knowledge. The results of the MCQ test were statistically analyzed. Results: The students found the jigsaw session to be more engaging than traditional classes. MCQ scores were more in the study group than in the control group. Conclusion: The jigsaw technique is both an educational and enjoyable way of teaching. Due to its immense benefits, both students and teachers resolved to use this technique in the future as well.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41693612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Dhikale, S. Chavhan, B. Adsul, Chinmay N. Gokhale, Aniket R. Ingale, K. Kinge
Objectives: Our study aimed to evaluate the risk factors for the cessation of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) RNA detection in a cohort of inpatients of laboratory-confirmed coronavirus disease 2019 (COVID-19) cases. Materials and Methods: This was a hospital-based, cross-sectional study. All COVID-19 patients positive on the reverse transcription polymerase chain reaction (RTPCR) test of nasopharyngeal samples who were admitted in this Dedicated COVID Hospital (DCH) from April to June 2020 were included in this study. The deceased patients were excluded.Cessation of Viral RNA Shedding (CVS) was considered to have been achieved on the date of the first negative SARS-CoV-2 RTPCR result out of the two consecutive negative SARS-CoV-2 PCR results on nasopharyngeal swabs taken 24 h apart. Results: Of the 4632 COVID-19 patients, 3307 (71.4%) patients achieved CVS. Patients had a median (IQR) time from positive to negative PCR of 16 (11–23) days. In multivariate cox regression analysis, age group 41 − 60 years (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.63–0.91), age >60 years (HR [CI] = 0.63 [0.53–0.78]), female sex (HR [CI] = 1.08 [1.01-1.16]), cancer (HR [CI] = 1.87 [1.03–3.41]) were the independent risk factors for cessation of viral shedding. Conclusion: Patients older than 40 years, male patients were shedding viral RNA for more duration and can be considered for the isolation for a longer duration.
{"title":"Risk factors for cessation of viral RNA shedding in COVID-19 patients","authors":"P. Dhikale, S. Chavhan, B. Adsul, Chinmay N. Gokhale, Aniket R. Ingale, K. Kinge","doi":"10.4103/jss.jss_87_21","DOIUrl":"https://doi.org/10.4103/jss.jss_87_21","url":null,"abstract":"Objectives: Our study aimed to evaluate the risk factors for the cessation of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) RNA detection in a cohort of inpatients of laboratory-confirmed coronavirus disease 2019 (COVID-19) cases. Materials and Methods: This was a hospital-based, cross-sectional study. All COVID-19 patients positive on the reverse transcription polymerase chain reaction (RTPCR) test of nasopharyngeal samples who were admitted in this Dedicated COVID Hospital (DCH) from April to June 2020 were included in this study. The deceased patients were excluded.Cessation of Viral RNA Shedding (CVS) was considered to have been achieved on the date of the first negative SARS-CoV-2 RTPCR result out of the two consecutive negative SARS-CoV-2 PCR results on nasopharyngeal swabs taken 24 h apart. Results: Of the 4632 COVID-19 patients, 3307 (71.4%) patients achieved CVS. Patients had a median (IQR) time from positive to negative PCR of 16 (11–23) days. In multivariate cox regression analysis, age group 41 − 60 years (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.63–0.91), age >60 years (HR [CI] = 0.63 [0.53–0.78]), female sex (HR [CI] = 1.08 [1.01-1.16]), cancer (HR [CI] = 1.87 [1.03–3.41]) were the independent risk factors for cessation of viral shedding. Conclusion: Patients older than 40 years, male patients were shedding viral RNA for more duration and can be considered for the isolation for a longer duration.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42224066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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