Hypospadias is a common congenital anomaly. Treatment for hypospadias is surgical, but there is no technique that is recognized as the gold standard. The most common complication occurring after hypospadias repair is urethrocutaneous fistula with a reported incidence varying from 4% to 28%. The use of an intermediate layer between the neourethra and the skin is one of the most important techniques used to reduce the likelihood of fistula formation. Several coverage techniques have been described including local subcutaneous penile tissue, tunica vaginalis, dartos, and extragenital tissues. In addition to tissue flaps, fibrin sealants have been introduced to prevent fistula formation. Platelet-rich fibrin membrane is an autologous source of growth factors and has been used to prevent fistulous complications.
{"title":"Use of platelet-rich fibrin in hypospadias surgery","authors":"Rajendra Nerli, S. Rangrez, C. Saniya","doi":"10.4103/jss.jss_123_22","DOIUrl":"https://doi.org/10.4103/jss.jss_123_22","url":null,"abstract":"Hypospadias is a common congenital anomaly. Treatment for hypospadias is surgical, but there is no technique that is recognized as the gold standard. The most common complication occurring after hypospadias repair is urethrocutaneous fistula with a reported incidence varying from 4% to 28%. The use of an intermediate layer between the neourethra and the skin is one of the most important techniques used to reduce the likelihood of fistula formation. Several coverage techniques have been described including local subcutaneous penile tissue, tunica vaginalis, dartos, and extragenital tissues. In addition to tissue flaps, fibrin sealants have been introduced to prevent fistula formation. Platelet-rich fibrin membrane is an autologous source of growth factors and has been used to prevent fistulous complications.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139343853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is widely recognized that Vitamin B12, also known as cyanocobalamin, is a nutrient that keeps the body's nerves and blood cells healthy and contributes in deoxyribonucleic acid synthesis. Megaloblastic anemia, a form of anemia that causes fatigue and weakness, can be prevented with Vitamin B12. The main objective of this case report was to draw attention to the rare hypersensitive reactions which can occur after injecting Vitamin B12 supplement therapy. The abovementioned reaction could be a result to an immunoglobulin E-mediated reaction or due to sensitization to the Vitamin B12 molecule itself. Here, we have reported the case of a 25-year-old female patient, a known case of pulmonary tuberculosis, who was hospitalized and on medication of fixed dose of directly observed treatment, short-course, nebulizer Combimist, tablet beclomethasone, and cyanocobalamin injection. We deduce that the anaphylactoid reaction to Vitamin B12 is a rare but serious side effect and that it should be vigilantly monitored while administering the drug to the patient, especially if the parenteral route is preferred.
{"title":"Cyanocobalamin-induced anaphylactic reaction","authors":"C. Sajan, Elizabeth Jacob","doi":"10.4103/jss.jss_180_22","DOIUrl":"https://doi.org/10.4103/jss.jss_180_22","url":null,"abstract":"It is widely recognized that Vitamin B12, also known as cyanocobalamin, is a nutrient that keeps the body's nerves and blood cells healthy and contributes in deoxyribonucleic acid synthesis. Megaloblastic anemia, a form of anemia that causes fatigue and weakness, can be prevented with Vitamin B12. The main objective of this case report was to draw attention to the rare hypersensitive reactions which can occur after injecting Vitamin B12 supplement therapy. The abovementioned reaction could be a result to an immunoglobulin E-mediated reaction or due to sensitization to the Vitamin B12 molecule itself. Here, we have reported the case of a 25-year-old female patient, a known case of pulmonary tuberculosis, who was hospitalized and on medication of fixed dose of directly observed treatment, short-course, nebulizer Combimist, tablet beclomethasone, and cyanocobalamin injection. We deduce that the anaphylactoid reaction to Vitamin B12 is a rare but serious side effect and that it should be vigilantly monitored while administering the drug to the patient, especially if the parenteral route is preferred.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.5958/2230-7273.2022.00035.7
Prince Kumar, Swarndeep Singh, S. Mishra
Background: The precision fit at the implant-abutment interface is a significant criterion for the success of implant restorations clinically. Various factors are involved in it, including fabrication techniques and utilized materials. The misfit at the implant-abutment interface is capable of causing screw loosening and fracture of the abutment screws. Aim: The aim of the study was to evaluate the marginal fit of premachined and castable abutment at implant-abutment connection interface using stereomicroscope. Materials and Methods: Fifteen castable abutments (Group A) and 15 premachined titanium abutments (Group B) were used for the study and connected to titanium implants and evaluated under the stereomicroscope. Images of the sample were recorded at three equidistant points at the implant-abutment interface to measure the vertical microgap at the platform level. The data were subjected to statistical evaluation using the “t”-test. Results: Data were sent for the statistical analysis by the software Statistical Package for the Social Sciences version. The mean for Group A (customized abutments) at mesiobuccal point was 13.2199 with a standard error of 0.5281. For premachined abutments, it was 6.4629 and with a standard error of 0.3201. Similarly, the mean for Group A (customized abutments) at the distobuccal point was 12.0861 with a standard error of 0.3428. On comparative assessment, the mean microgap in between the groups showed significant difference (Tukey test). Conclusion: On implant-abutment interface at the platform level, the microgaps of premachined implant abutments were significantly lesser than the casted implant abutments. Furthermore, the microgap of both tested groups was found within the clinically acceptable ranges.
背景:种植体-基牙界面的精确配合是临床种植体修复成功的重要标准。它涉及各种因素，包括制造技术和使用的材料。种植体-基牙界面处的不配合会导致基牙螺钉松动和断裂。目的:应用体视显微镜评价预制基牙与铸造基牙在种植体-基牙连接界面的边缘配合度。材料与方法:采用15个铸造基牙(A组)和15个预制钛基牙(B组)，与钛种植体连接，体视显微镜下观察。在种植体-基牙界面的三个等距点记录样品的图像，以测量平台水平的垂直微间隙。数据采用“t”检验进行统计评价。结果:使用statistical Package for Social Sciences version软件发送数据进行统计分析。A组(定制基牙)在中颊点的平均值为13.2199，标准误差为0.5281。预加工基台的标准误差为6.4629，标准误差为0.3201。同样，A组(定制基台)在分布点的平均值为12.0861，标准误差为0.3428。经比较，两组间平均微差差异有统计学意义(Tukey检验)。结论:在种植体-基台交界面上，预制基台的微间隙明显小于铸造基台。此外，两组的微间隙均在临床可接受的范围内。
{"title":"Stereomicroscopic evaluation of marginal fit of premachined and castable abutments at implant abutment connection interface – An In Vitro study","authors":"Prince Kumar, Swarndeep Singh, S. Mishra","doi":"10.5958/2230-7273.2022.00035.7","DOIUrl":"https://doi.org/10.5958/2230-7273.2022.00035.7","url":null,"abstract":"Background: The precision fit at the implant-abutment interface is a significant criterion for the success of implant restorations clinically. Various factors are involved in it, including fabrication techniques and utilized materials. The misfit at the implant-abutment interface is capable of causing screw loosening and fracture of the abutment screws. Aim: The aim of the study was to evaluate the marginal fit of premachined and castable abutment at implant-abutment connection interface using stereomicroscope. Materials and Methods: Fifteen castable abutments (Group A) and 15 premachined titanium abutments (Group B) were used for the study and connected to titanium implants and evaluated under the stereomicroscope. Images of the sample were recorded at three equidistant points at the implant-abutment interface to measure the vertical microgap at the platform level. The data were subjected to statistical evaluation using the “t”-test. Results: Data were sent for the statistical analysis by the software Statistical Package for the Social Sciences version. The mean for Group A (customized abutments) at mesiobuccal point was 13.2199 with a standard error of 0.5281. For premachined abutments, it was 6.4629 and with a standard error of 0.3201. Similarly, the mean for Group A (customized abutments) at the distobuccal point was 12.0861 with a standard error of 0.3428. On comparative assessment, the mean microgap in between the groups showed significant difference (Tukey test). Conclusion: On implant-abutment interface at the platform level, the microgaps of premachined implant abutments were significantly lesser than the casted implant abutments. Furthermore, the microgap of both tested groups was found within the clinically acceptable ranges.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45010755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Platelet-rich plasma (PRP) is a highly enriched combination of growth factors and pro-inflammatory cytokines which has shown success in cartilage healing. Furthermore, the fibrinogen in PRP may be triggered to produce a fibrin matrix to fill articular defects, so satisfying the basic needs of biological wound repair. The proliferative, anti-inflammatory, and scaffolding properties of PRP are discussed in this article obtained from laboratory experiments, observational studies, and clinical testing. PRP has been seen in culture to boost cell growth and calcareous matrix formation by osteocytes and mature mesenchymal stem cells (MSCs), promote matrix release by synoviocytes, reduce interleukin-1-induced inflammatory, and offer a favorable platform for MSCs. PRP has been utilized in preclinical trials as a hydrogel to fill cartilage deficiencies with varying results, or to stop the course of disease in animal models with beneficial results. Existing medical study findings indicate that PRP may have the capacity to fill tissue defects to promote cartilage regeneration, alleviate arthritis symptoms, and boost joint mobility while maintaining a reasonable safety profile. Despite the fact that current data indicates to prefer PRP above hyaluronan for the management of pain, the effectiveness of PRP therapies is undetermined due to the very diverse character of published research and the varying content of PRP formulations. Future research will be needed to identify the functional group actions of specific PRP components in modifying certain disease pathways.
{"title":"A review on the experimental role of platelet-rich plasma as a biological stimulator for cartilage regeneration","authors":"Kuldeep Chhatbar","doi":"10.4103/jss.jss_106_22","DOIUrl":"https://doi.org/10.4103/jss.jss_106_22","url":null,"abstract":"Platelet-rich plasma (PRP) is a highly enriched combination of growth factors and pro-inflammatory cytokines which has shown success in cartilage healing. Furthermore, the fibrinogen in PRP may be triggered to produce a fibrin matrix to fill articular defects, so satisfying the basic needs of biological wound repair. The proliferative, anti-inflammatory, and scaffolding properties of PRP are discussed in this article obtained from laboratory experiments, observational studies, and clinical testing. PRP has been seen in culture to boost cell growth and calcareous matrix formation by osteocytes and mature mesenchymal stem cells (MSCs), promote matrix release by synoviocytes, reduce interleukin-1-induced inflammatory, and offer a favorable platform for MSCs. PRP has been utilized in preclinical trials as a hydrogel to fill cartilage deficiencies with varying results, or to stop the course of disease in animal models with beneficial results. Existing medical study findings indicate that PRP may have the capacity to fill tissue defects to promote cartilage regeneration, alleviate arthritis symptoms, and boost joint mobility while maintaining a reasonable safety profile. Despite the fact that current data indicates to prefer PRP above hyaluronan for the management of pain, the effectiveness of PRP therapies is undetermined due to the very diverse character of published research and the varying content of PRP formulations. Future research will be needed to identify the functional group actions of specific PRP components in modifying certain disease pathways.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46880468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Sajan, H. Patel, Dullari Patel, Twinkal Patet, Bhumi Vadodariya, H. Rajput
Background: Depression is one of the most common mental disorders. There is evidence that depression is more common among college students. Diminished capacity to do regular chores and decreased quality of life are frequent complaints. The objectives of our study are to assess the depression in gender disparity and to assess the depression in the field of pharmacy on graduate and undergraduate students. Materials and Methods: In India, from the state of Gujarat, 7 institutes participated in the study. The updated Centre for Epidemiologic Studies Depression Scale was implemented in this investigation. The sample size is 370 in total. Results: Among 370 students, 56.49% were male and 43.51% were female. The study has shown that students of pharmacy who lived at their relative's place have experienced severe depression in a greater number (81.36%). Mild depression was commonly found in students who lived at home (35.32%). Students who were new to course, i.e., 1st-year students in a greater number have experienced severe depression (67.19%). A greater number of students from colleges of the east-central area suffered from severe depression (33.78%). Severe depression was found to be common in M. Pharm students among all students (70.83%). Conclusion: The study indicated that male students were more likely than female students to experience more depression. Students who were new to the course and students who were in master degree had a higher risk of severe depression.
{"title":"Prevalence of depression among pharmacy students of Gujarat","authors":"C. Sajan, H. Patel, Dullari Patel, Twinkal Patet, Bhumi Vadodariya, H. Rajput","doi":"10.4103/jss.jss_179_22","DOIUrl":"https://doi.org/10.4103/jss.jss_179_22","url":null,"abstract":"Background: Depression is one of the most common mental disorders. There is evidence that depression is more common among college students. Diminished capacity to do regular chores and decreased quality of life are frequent complaints. The objectives of our study are to assess the depression in gender disparity and to assess the depression in the field of pharmacy on graduate and undergraduate students. Materials and Methods: In India, from the state of Gujarat, 7 institutes participated in the study. The updated Centre for Epidemiologic Studies Depression Scale was implemented in this investigation. The sample size is 370 in total. Results: Among 370 students, 56.49% were male and 43.51% were female. The study has shown that students of pharmacy who lived at their relative's place have experienced severe depression in a greater number (81.36%). Mild depression was commonly found in students who lived at home (35.32%). Students who were new to course, i.e., 1st-year students in a greater number have experienced severe depression (67.19%). A greater number of students from colleges of the east-central area suffered from severe depression (33.78%). Severe depression was found to be common in M. Pharm students among all students (70.83%). Conclusion: The study indicated that male students were more likely than female students to experience more depression. Students who were new to the course and students who were in master degree had a higher risk of severe depression.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45673708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abolfazl Taher, M. Sadrabad, Armin Izadi, R. Ghorbani, Shabnam Sohanian, E. Saberian
Backround: In this study, we aimed to investigate the effect of dentin matrix proteins on the differentiation of guinea pig dental pulp stem cells to regenerate Dentin Bridge. Materials and Methods: This experimental study was performed on six adult male guinea pigs. Pig incisor teeth were divided into two groups: the first group was induced by calcium hydroxide as a control group and the second group was induced by matrix protein induction as a case group. After 1 and 3 days, the samples of both groups were stained by hematoxylin and eosin to examine the presence of odontoblast-like cells, the severity of inflammation, and the type and amount of dentin which was made, microscopically and for counting stem cells in the dentin site. Immunohistochemistry staining method was done. Results: In the case group, the amount of reconstituted dentin, the presence of stem cells and odontoblastic differentiation were higher than in the control group (P < 0.05) and the type of regenerated dentin potentially was of higher quality, although it was not statistically significant (P = 0.924). However, the amount of regenerated dentin (P = 0.001), the presence of pulp stem cells (P = 0.001) and the increased quality of regenerated dentin (P = 0.001) in both groups on the 1st and 3rd days were significantly different. Conclusion: The results showed that dentin matrix proteins were more effective on stem cell migration, odontoblastic differentiation, amount and quality of restorative dentin than the control group, but did not significantly; probably because low sample size.
{"title":"The effect of dentin matrix proteins on differentiation of autologous guinea pig dental pulp stem cells","authors":"Abolfazl Taher, M. Sadrabad, Armin Izadi, R. Ghorbani, Shabnam Sohanian, E. Saberian","doi":"10.4103/jss.jss_186_22","DOIUrl":"https://doi.org/10.4103/jss.jss_186_22","url":null,"abstract":"Backround: In this study, we aimed to investigate the effect of dentin matrix proteins on the differentiation of guinea pig dental pulp stem cells to regenerate Dentin Bridge. Materials and Methods: This experimental study was performed on six adult male guinea pigs. Pig incisor teeth were divided into two groups: the first group was induced by calcium hydroxide as a control group and the second group was induced by matrix protein induction as a case group. After 1 and 3 days, the samples of both groups were stained by hematoxylin and eosin to examine the presence of odontoblast-like cells, the severity of inflammation, and the type and amount of dentin which was made, microscopically and for counting stem cells in the dentin site. Immunohistochemistry staining method was done. Results: In the case group, the amount of reconstituted dentin, the presence of stem cells and odontoblastic differentiation were higher than in the control group (P < 0.05) and the type of regenerated dentin potentially was of higher quality, although it was not statistically significant (P = 0.924). However, the amount of regenerated dentin (P = 0.001), the presence of pulp stem cells (P = 0.001) and the increased quality of regenerated dentin (P = 0.001) in both groups on the 1st and 3rd days were significantly different. Conclusion: The results showed that dentin matrix proteins were more effective on stem cell migration, odontoblastic differentiation, amount and quality of restorative dentin than the control group, but did not significantly; probably because low sample size.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41724986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dentistry is a professional field, and patients receive dental care in a straightforward way owing to the use of tactile abilities. Haptics act of identifying things through touch. It is an innovation in both medical and dentistry procedures. The current revelations have proposed that haptic and virtual technologies might improve dentistry education outcomes, and scientific data have supported the use of virtual technology in dentistry. With the utilization of haptics, students can acquire skills without putting a strain on resources or labor by obtaining access to an unlimited number of training hours. This review offers a succinct overview of the haptics literature for educating dental students.
{"title":"A review of haptics in dental surgery","authors":"J. Ramachandra, S. Siddaiah, Somya Sinha","doi":"10.4103/jss.jss_173_22","DOIUrl":"https://doi.org/10.4103/jss.jss_173_22","url":null,"abstract":"Dentistry is a professional field, and patients receive dental care in a straightforward way owing to the use of tactile abilities. Haptics act of identifying things through touch. It is an innovation in both medical and dentistry procedures. The current revelations have proposed that haptic and virtual technologies might improve dentistry education outcomes, and scientific data have supported the use of virtual technology in dentistry. With the utilization of haptics, students can acquire skills without putting a strain on resources or labor by obtaining access to an unlimited number of training hours. This review offers a succinct overview of the haptics literature for educating dental students.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41666685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Multisystem inflammatory syndrome in children (MIS-C) is a postviral complication that has been described among children after 2–6 weeks of exposure to the COVID-19 virus from various parts of the world. Published literature regarding MIS-C in children is limited. The aim of this study was to investigate the disease management and clinical outcomes of a larger group of children from North India presenting with features of MIS-C. Materials and Methods: This is an observational study of children with MIS-C, admitted to the pediatric intensive care unit (PICU) between March 1, 2021, and August 31, 2021, during the second wave of SARS-CoV-2 infection in India. Results: Out of the 37 children presenting with MIS-C, 62% of patients were male and 37% were female patients. Vasoactive medications were required in 14 patients. Eighteen patients required respiratory support, of which 17 received noninvasive ventilation and only one patient required invasive mechanical ventilation. Methylprednisolone and intravenous immunoglobulin (IVIG) were used in the majority of patients. No patient required remdesivir. Thirty-six patients were discharged home with a median duration of 4 days in PICU and a hospital stay of 10 days, only 1 (2.7%) patient died during the treatment. Thirty-five (94.5%) patients received IVIG alone, and five patients (13.5%) received IVIG along with methylprednisolone. Patients who received a combination of steroids and IVIG had greater severity of illness, deranged laboratory parameters, highly raised inflammatory markers, requiring higher inotropes, respiratory support, PICU requirement, and length of stay in hospital. Conclusions: The decision to treat MIS-C patients with IVIG plus methylprednisolone or IVIG alone must be reviewed on an individual basis. IVIG in conjunction with methylprednisolone should be considered for patients with severe MIS-C and hypotension who have been admitted to the PICU.
{"title":"Treatment response and short-term outcomes in children admitted as multisystem inflammatory syndrome in children","authors":"M. Batt, G. Saini, M. Dar","doi":"10.4103/jss.jss_210_22","DOIUrl":"https://doi.org/10.4103/jss.jss_210_22","url":null,"abstract":"Background: Multisystem inflammatory syndrome in children (MIS-C) is a postviral complication that has been described among children after 2–6 weeks of exposure to the COVID-19 virus from various parts of the world. Published literature regarding MIS-C in children is limited. The aim of this study was to investigate the disease management and clinical outcomes of a larger group of children from North India presenting with features of MIS-C. Materials and Methods: This is an observational study of children with MIS-C, admitted to the pediatric intensive care unit (PICU) between March 1, 2021, and August 31, 2021, during the second wave of SARS-CoV-2 infection in India. Results: Out of the 37 children presenting with MIS-C, 62% of patients were male and 37% were female patients. Vasoactive medications were required in 14 patients. Eighteen patients required respiratory support, of which 17 received noninvasive ventilation and only one patient required invasive mechanical ventilation. Methylprednisolone and intravenous immunoglobulin (IVIG) were used in the majority of patients. No patient required remdesivir. Thirty-six patients were discharged home with a median duration of 4 days in PICU and a hospital stay of 10 days, only 1 (2.7%) patient died during the treatment. Thirty-five (94.5%) patients received IVIG alone, and five patients (13.5%) received IVIG along with methylprednisolone. Patients who received a combination of steroids and IVIG had greater severity of illness, deranged laboratory parameters, highly raised inflammatory markers, requiring higher inotropes, respiratory support, PICU requirement, and length of stay in hospital. Conclusions: The decision to treat MIS-C patients with IVIG plus methylprednisolone or IVIG alone must be reviewed on an individual basis. IVIG in conjunction with methylprednisolone should be considered for patients with severe MIS-C and hypotension who have been admitted to the PICU.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41879790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vidya M. Mahalmani, N. Hashilkar, A. Hogade, Netravathi Basavaraj
Objectives: The purpose of the study was to understand the perception of 2nd-year medical undergraduates regarding the implementation of competency-based medical education (CBME) in pharmacology. Materials and Methods: This cross-sectional study was undertaken by the department of pharmacology, in our institution. Out of 197 s year medical undergraduate students, 192 provided their valuable feedback. The questionnaire consisted of three types of questions: (1) multiple-choice questions, (2) rating on a 5-point Likert scale, and (3) open-ended questions. In the open-ended questions, the students were asked to share their views. Responses to the questions were recorded. Students' “feedback responses” were scrutinized in terms of percentages. Conceptual content analysis was done for open-ended questions. Results: Students were satisfied with the implementation of CBME as well as the conduct of small group teaching, self-directed learning, integrated assessment, attitude, ethics, and communication skills, and pandemic modules. They emphasized more on game-based learning and other innovative teaching–learning methods that drove their interest to understand the subject better. Conclusion: Implementation of CBME has been found to be more effective than the traditional didactic approach.
{"title":"Perception of 2nd-Year medical undergraduates regarding the implementation of competency-Based medical education in pharmacology","authors":"Vidya M. Mahalmani, N. Hashilkar, A. Hogade, Netravathi Basavaraj","doi":"10.4103/jss.jss_224_22","DOIUrl":"https://doi.org/10.4103/jss.jss_224_22","url":null,"abstract":"Objectives: The purpose of the study was to understand the perception of 2nd-year medical undergraduates regarding the implementation of competency-based medical education (CBME) in pharmacology. Materials and Methods: This cross-sectional study was undertaken by the department of pharmacology, in our institution. Out of 197 s year medical undergraduate students, 192 provided their valuable feedback. The questionnaire consisted of three types of questions: (1) multiple-choice questions, (2) rating on a 5-point Likert scale, and (3) open-ended questions. In the open-ended questions, the students were asked to share their views. Responses to the questions were recorded. Students' “feedback responses” were scrutinized in terms of percentages. Conceptual content analysis was done for open-ended questions. Results: Students were satisfied with the implementation of CBME as well as the conduct of small group teaching, self-directed learning, integrated assessment, attitude, ethics, and communication skills, and pandemic modules. They emphasized more on game-based learning and other innovative teaching–learning methods that drove their interest to understand the subject better. Conclusion: Implementation of CBME has been found to be more effective than the traditional didactic approach.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46381026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Agrawal, Bhushan Madke, Sugat A Jawade, A. Singh
Imatinib mesylate is an oral tyrosine kinase inhibitor used chiefly to treat chronic myeloid leukemia. In the literature, hypopigmentation is a commonly reported side effect of imatinib therapy; however, the cases of melasma-like hyperpigmentation due to imatinib have also been sparingly reported. We report a 35-year-old male patient who had asymptomatic hyperpigmentation over the cheeks and nose for 3 months after being started with oral imatinib. Examination showed pigmentation confined to the cheeks and nose. The diagnosis was made clinically along with dermoscopy, and the patient was treated with conventional skin-lightening regimen and sunscreen.
{"title":"Melasma-like hyperpigmentation: A rare side effect of imatinib mesylate","authors":"S. Agrawal, Bhushan Madke, Sugat A Jawade, A. Singh","doi":"10.4103/jss.jss_225_22","DOIUrl":"https://doi.org/10.4103/jss.jss_225_22","url":null,"abstract":"Imatinib mesylate is an oral tyrosine kinase inhibitor used chiefly to treat chronic myeloid leukemia. In the literature, hypopigmentation is a commonly reported side effect of imatinib therapy; however, the cases of melasma-like hyperpigmentation due to imatinib have also been sparingly reported. We report a 35-year-old male patient who had asymptomatic hyperpigmentation over the cheeks and nose for 3 months after being started with oral imatinib. Examination showed pigmentation confined to the cheeks and nose. The diagnosis was made clinically along with dermoscopy, and the patient was treated with conventional skin-lightening regimen and sunscreen.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42729637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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