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A case report on smear-Positive pulmonary tuberculosis with neurofibromatosis type-1 涂阳肺结核合并1型神经纤维瘤病1例报告
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_191_22
Khushboo Chavda, S. Mistry, C. Sajan
Neurofibromatosis (NF) is a group of disorders that is caused by a genetic mutation which is dominantly inherited neurogenetic disorder. They are of three types: NF1, NF2, and schwannomatosis. Out of these three, NF1 is the most common. NF1 mainly affects the skin, peripheral and central nervous system, bones, cardiovascular, and endocrine systems. Tuberculosis is a bacterial infection of the lung that is caused by Mycobacterium tuberculosis. It spreads by speaking, sneezing, and coughing in the air. Active pulmonary infections can spread to other people. Here, we represent a case of a 45-year-old male diagnosed with pulmonary tuberculosis (PTB) presenting with breathlessness, fever, loss of appetite, runny nose, nervousness, and dry cough. The patient had multiple swellings over the body with papules and nodules seen on different parts of the body. Cafe-au-lait macules were also present. After the all-over examination, the patient was diagnosed with smear-positive PTB with NF1.
神经纤维瘤病(NF)是一组由基因突变引起的疾病,主要是遗传性神经遗传疾病。它们有三种类型:NF1、NF2和神经鞘瘤病。在这三种类型中,NF1是最常见的。NF1主要影响皮肤、周围和中枢神经系统、骨骼、心血管和内分泌系统。结核病是一种由结核分枝杆菌引起的肺部细菌感染。它通过说话、打喷嚏和咳嗽在空气中传播。活动性肺部感染可以传播给其他人。在此,我们报告一例45岁男性肺结核(PTB),表现为呼吸困难、发烧、食欲不振、流鼻涕、紧张和干咳。患者全身多处肿胀,不同部位可见丘疹和结节。此外,还发现了咖啡黑斑。经全身检查,诊断为痰阳性结核伴NF1。
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引用次数: 0
Aldehyde dehydrogenase isoform 1 as an indicator in the malignant potential of cutaneous lichen planus 醛脱氢酶异构体1在皮肤扁平苔藓恶性潜能中的指示作用
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_62_22
F. Aliakbarpour, Robabeh Alijanpour, R. Ghorbani, Saba Bisheh, Arezoo Kashfi, Shabnam Sohanian
Introduction: Hypertrophic variant of cutaneous lichen planus (CLP) is a chronic variant with controversial malignant association. Since aldehyde dehydrogenase isoform 1 (ALDH1) is considered as a prognostic marker in various cancers and its expression was significantly associated with malignant transformation in the oral type of lichen planus. So we decided to assess the ALDH1 expression in CLP in order to know the role of this biomarker in the CLP. Materials and Methods: Thirty blocks of CLP from the archive of Dermatology Department of Babol University of Medical Sciences and 30 blocks of normal skin as the control group were selected. Immunohistochemical staining for ALDH1 marker was performed. In terms of evaluation of the ALDH1 expression, the percentage of stained cells as well as the intensity of cytoplasmic staining was considered. Results: In this study, the percentage of stained cells, the intensity of staining the epidermal cells, and the final score of the ALDH-1 expression were significantly different between two groups (P < 0.001). There was no significant relationship between ALDH-1 expressions and sex (P = 0.0202), and also, lesion location and final score (P = 0.345). No correlation was found between age and ALDH-1 expression (P = 0.217, r = 0.232). Conclusion: To sum up, ALDH1 was significantly expressed in CLP; furthermore, the expression may be correlated with malignant transformation. Consequently, ALDH1 might be an independent prognostic indicator in CLP. However, further studies with larger patient samples are required to verify the findings of the current study.
简介:皮肤扁平苔藓(CLP)的肥大性变体是一种有争议的恶性关联的慢性变体。由于醛脱氢酶亚型1(ALDH1)被认为是各种癌症的预后标志物,并且其表达与口腔型扁平苔藓的恶性转化显著相关。因此,我们决定评估CLP中ALDH1的表达,以了解该生物标志物在CLP中的作用。材料与方法:选用巴勃尔医科大学皮肤科档案馆CLP 30块,正常皮肤30块作为对照组。对ALDH1标记物进行免疫组织化学染色。在评估ALDH1表达方面,考虑了染色细胞的百分比以及细胞质染色的强度。结果:在本研究中,两组染色细胞的百分比、表皮细胞的染色强度和ALDH-1表达的最终评分有显著差异(P<0.001)。ALDH-1的表达与性别无显著关系(P=0.0202),病变位置和最终评分(P=0.345)。年龄与ALDH-1表达之间没有相关性(P=0.217,r=0.232)。结论:总之,ALDH1在CLP中显著表达;此外,该表达可能与恶性转化有关。因此,ALDH1可能是CLP的独立预后指标。然而,需要对更大的患者样本进行进一步研究,以验证当前研究的结果。
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引用次数: 0
Identification and management of Snake Bite in Asia: A narrative review 亚洲地区蛇咬伤的鉴定与管理:述评
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_92_22
M. Rathinasamy, M. Mithuna, S. Ramasamy, Jane Antony, V. Jaishree, M. Alexander
Snake bites are an important cause of illness and deaths in the rural population in tropical, subtropical and southeast Asian countries. There are more than 3000 species of snakes found all over the world of which around 300 species are found in India. In India, most of snake bite deaths occur due to delayed arrival to treatment centers. The purpose of the present review article is to explore the various species of snakes, their toxicology, clinical manifestations, and management. In addition, various ways to avoid snake bites and early approaches to government centers rather than private centers for the availability of Anti-snake venom have been discussed in this article. Rapid diagnostic test for the identification of species is available in selective centers only and treatment mainly depends on the administration of anti-snake venom. In addition, proper community education and strong health-care policy will reduce the morbidity and mortality due to snake bites.
蛇咬伤是热带、亚热带和东南亚国家农村人口患病和死亡的重要原因。世界各地发现的蛇有3000多种,其中约300种在印度发现。在印度,大多数被蛇咬致死的原因是延迟到达治疗中心。这篇综述文章的目的是探讨各种蛇,它们的毒理学,临床表现和管理。此外,本文还讨论了避免被蛇咬伤的各种方法,以及早期向政府中心而非私人中心提供抗蛇毒的方法。鉴定物种的快速诊断测试只能在选择性中心进行,治疗主要取决于抗蛇毒的给药。此外,适当的社区教育和强有力的卫生保健政策将降低因蛇咬伤而导致的发病率和死亡率。
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引用次数: 0
Post-Coronavirus disease 2019 condition 2019冠状病毒后疾病状态
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_237_23
R. Nerli, S. Rangrez
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引用次数: 0
Transgender health and medical education: the existing gaps and the need for curricular reforms – A systematic review 跨性别健康和医学教育:现有差距和课程改革的必要性——系统综述
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_56_22
S. Shrivastava, P. Shrivastava
Time and again it has been envisaged that health-care services imparted should be inclusive and should be equitably distributed regardless of any sociodemographic determinants. The purpose of the current review is to identify the problems encountered by transgender people and the role of medical education in preparing medical professionals who are competent enough to address their special needs. An extensive search of all materials related to the topic was carried out on the PubMed and Google Scholar search engines, and a total of 49 articles were selected based on their suitability with the current review objectives. Keywords used in the search include transgender and medical education in the title alone only. A number of studies and review articles have concluded that there is an urgent need to augment the knowledge, skills, and attitude of medical students to improve the clinical care of transgender people. Medical educators have to acknowledge the need and take concerted efforts to ensure the delivery of holistic, transgender-specific health-care education to all medical students. To conclude, transgender people have been subjected to a wide range of challenging circumstances that have significantly impacted their chances to avail of health care. One of the potential reasons for this is the lack of sensitization of medical doctors about transgender health in the current era. There is an immense need to bridge the existing gap, and it has to begin with bringing about curricular reforms and preparing the current crop of medical students about issues pertaining to transgender health during their training period.
人们一再设想,提供的保健服务应具有包容性,并应公平分配,而不考虑任何社会人口决定因素。目前审查的目的是确定跨性别者遇到的问题,以及医学教育在培养有能力满足其特殊需求的医学专业人员方面的作用。在PubMed和Google Scholar搜索引擎上对与该主题相关的所有材料进行了广泛搜索,根据其与当前审查目标的适用性,共选择了49篇文章。搜索中使用的关键词仅在标题中包括变性人和医学教育。许多研究和综述文章得出结论,迫切需要提高医学生的知识、技能和态度,以改善跨性别者的临床护理。医学教育工作者必须认识到这一必要性,并采取一致努力,确保向所有医学生提供针对跨性别的全面健康教育。总之,跨性别者经历了一系列具有挑战性的环境,这些环境严重影响了他们获得医疗保健的机会。造成这种情况的一个潜在原因是,在当前时代,医生对跨性别健康缺乏敏感性。迫切需要弥合现有的差距,必须首先进行课程改革,并让当前这批医学生在培训期间就跨性别健康问题做好准备。
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引用次数: 1
Assessment of anxiety and behavior changes on digital education in undergraduate dental students during COVID-19 pandemic 新冠肺炎大流行期间牙科本科学生数字化教育焦虑与行为变化评估
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_16_22
Shaila V Kothiwale, Vishakha Padhye
Context: Due to the COVID-19 pandemic, to avoid community spread of the disease, various academic institutions were closed to prevent infecting the students. Hence their relocation from the institution resulted in online academic learning. Reports indicated that the students undergoing online academic learning experienced distress in the form of anxiety, anger and insomnia. Aims: The aim of this study was to assess the changes in mental attitude, behavioral pattern, and anxiety level along with the impact of online education on academics so as to receive suggestions regarding digital education from undergraduate dental students. Settings and Design: An observational, cross-sectional study was conducted formulating online semi-structured, open-ended questionnaires, to obtain inputs regarding digital education using Google Forms and the snowball sampling method. Subjects and Methods: The data collection was initiated on August 6 at 4 PM IST and closed on August 13, 2020, at 4 PM IST. We received the response from 488 students from five dental institutions of Karnataka, Maharashtra, and Andhra Pradesh. Statistical analysis was performed using Microsoft Excel for obtaining an overall percentage of mental attitude, anxiety, behavior changes, and academics. IBM SPSS Statistics 20 software was used to evaluate correlation among all parameters with the analysis of variance test. Results: A statistically significant association was seen between digital education with anxiety (P = 0.015), behavior changes (P = 0.000), and academics (P = 0.000). Students contributed positive inputs to enhance the learning outcome in academics on the digital platform. Conclusions: Online academic sessions have eased the learning process to a certain extent, but this mode of education needs more refinement in the form of clinical demonstration videos, sharing of study material, well-planned and spaced definite timetable, and postsession evaluation. These suggestions were put forth by the students as feedback to make the experience entirely stress-free and aid their learning process.
背景:由于新冠肺炎大流行,为了避免疾病在社区传播,关闭了各种学术机构以防止感染学生。因此,他们从该机构的搬迁导致了在线学术学习。报告显示,接受在线学术学习的学生经历了焦虑、愤怒和失眠的痛苦。目的:本研究旨在评估在线教育对学术的影响,以及心理态度、行为模式和焦虑水平的变化,以获得牙科本科生对数字教育的建议。设置和设计:进行了一项观察性、横断面研究,制定了在线半结构化、开放式问卷,以使用谷歌表格和滚雪球抽样方法获得有关数字教育的投入。受试者和方法:数据收集于美国东部时间8月6日下午4点开始,于2020年8月13日美国东部时间下午4点结束。我们收到了来自卡纳塔克邦、马哈拉施特拉邦和安得拉邦五所牙科机构的488名学生的回复。使用Microsoft Excel进行统计分析,以获得心理态度、焦虑、行为变化和学业的总体百分比。采用IBM SPSS Statistics 20软件进行方差分析,评价各参数之间的相关性。结果:数字教育与焦虑(P=0.015)、行为变化(P=0.000)和学术(P=0.000。结论:在线学术会议在一定程度上缓解了学习过程,但这种教育模式需要更多的改进,包括临床演示视频、学习材料共享、计划周密、间隔明确的时间表以及课后评估。这些建议是由学生提出的反馈,以使体验完全没有压力,并有助于他们的学习过程。
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引用次数: 0
Study of bone marrow iron storage in patients presented with pancytopenia 全血细胞减少患者骨髓铁储存的研究
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_188_22
P. Bardapurkar, Ruchi Randive, Sushama Gurwale, C. Gore, V. Viswanathan
Introduction: Bone marrow examination is a useful technique for the evaluation of both hematological and nonhematological diseases. Perls Prussian blue stain is the “gold standard” to demonstrate the iron content and hemosiderin in the sideroblasts and the bone marrow macrophages. In our study, we assess the grades of iron storage in the bone marrow, as seen in various diseases in pancytopenia patients. Materials and Methods: An evaluation of iron storage in bone marrow aspirate of 140 patients of pancytopenia in a tertiary care center in western India, using Perls' stain and Gales' system of grading. Results: Out of all pancytopenia cases, 60.71% of the cases had low iron stores, 30% had normal, and 9.29% of cases had high iron stores, using Gales' system of iron stores grading. Dimorphic anemia was in the range of 0–3 iron store grade, with 72.4% having low iron stores, 24.6% having normal iron stores, and 2.8% having high iron stores. Megaloblastic anemia showed iron store grade in the range of 0–4, and iron-deficiency anemia showed decreased iron stores, along with multiple myeloma, acute lymphoblastic leukemia, and aplastic anemia. Conclusion: Gale's method of grading is used universally to grade iron stores in bone marrow aspirate as it is highly convenient and result oriented and it helps clinicians to plan necessary treatment accordingly.
骨髓检查是评估血液和非血液疾病的一项有用技术。珀尔斯普鲁士蓝染色是显示铁母细胞和骨髓巨噬细胞中铁含量和含铁血黄素的“金标准”。在我们的研究中,我们评估了骨髓中铁储存的等级,正如在全血细胞减少症患者的各种疾病中所看到的那样。材料和方法:对印度西部一家三级医疗中心140例全血细胞减少症患者骨髓抽吸液中铁的储存情况进行评估,采用Perls染色和Gales分级系统。结果:全血细胞减少患者中,铁储量低的占60.71%,正常的占30%,高铁储量的占9.29%。二形性贫血的铁储量在0-3级之间,其中72.4%的人铁储量低,24.6%的人铁储量正常,2.8%的人铁储量高。巨幼细胞性贫血表现为铁储存等级在0-4级之间,缺铁性贫血表现为铁储存降低,并伴有多发性骨髓瘤、急性淋巴细胞白血病和再生障碍性贫血。结论:Gale分级法对骨髓吸液中铁含量分级方便、结果导向,可为临床医生制定相应的治疗方案提供参考。
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引用次数: 0
Unusual combined dental attrition and erosion of primary teeth with its multiple risk factors: A rare pediatric case report with literature review 乳牙不寻常的合并牙磨损和侵蚀及其多重危险因素:一个罕见的儿科病例报告并文献复习
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_200_22
Mohammad Khan
Tooth wear (erosion, attrition, or abrasion) has been reported with variable prevalence in children. These clinical entities present a wide range of dental problems and difficulty in dental management in growing children. If tooth wear and its causative/risk factors in primary dentition are not timely addressed, it may negatively affect the permanent teeth later. The current article presents the pediatric case report of successful and effective dental management of a 7-year-old healthy child having dental erosion and attrition with the past history of gastroesophageal reflux disease and Bruxism concurrently in addition to dietary factors (acidic fruits juices and soft-drink). This case presentation has been thoroughly described in a step-wise systematic manner to demonstrate the evidence-based clinical approach for managing such tooth wear problems (combined lesions of erosion and abrasion) in the young pediatric patient by preventive and conservative dental treatment modalities along with appropriate behavior management techniques. Moreover, a review of relevant dental literature about tooth wear and its different clinical aspects has been discussed in this article.
据报道,牙齿磨损(侵蚀、磨损或磨损)在儿童中的患病率各不相同。这些临床实体在成长中的儿童中存在广泛的牙科问题和牙科管理困难。如果不及时解决乳牙列中的牙齿磨损及其原因/风险因素,可能会对恒牙产生负面影响。本文介绍了一名7岁健康儿童的儿科病例报告,该儿童患有牙齿侵蚀和磨损,除了饮食因素(酸性果汁和软饮料)外,还患有胃食管反流病和磨牙症。该病例介绍以循序渐进的系统方式进行了全面描述,以证明通过预防性和保守性牙科治疗模式以及适当的行为管理技术,在年轻儿科患者中管理此类牙齿磨损问题(侵蚀和磨损的联合病变)的循证临床方法。此外,本文还对有关牙齿磨损及其不同临床方面的相关文献进行了综述。
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引用次数: 0
Effect of Flutter Along with Conventional Chest Physiotherapy on Peak Expiratory Flow Rate among Coronary Artery Bypass Graft Patients 颤振与常规胸部物理治疗对冠状动脉搭桥术患者呼气峰值流速的影响
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_213_22
Sabnam Kapadia, T. Chokshi, M. Patel
Background: Coronary artery bypass graft (CABG) is extensively used to treat patients with heart problems. As it is a major surgery involving the thoracic cavity, lung function may be compromised postoperatively. Pulmonary dysfunction following CABG is inevitable. Chest physiotherapy (CPT) is a treatment to prevent postoperative pulmonary complications. Flutter is a form of positive expiratory pressure device in combination with high-frequency oscillation; it gives independence to patients and is easy to use for airway clearance. Aim: To study the effect of flutter along with conventional CPT on peak expiratory flow rate (PEFR) among CABG patients. Methodology: Twenty-seven CABG patients were selected through simple random sampling and assigned into two groups. Group 1 consisting of 13 patients was treated with conventional CPT, whereas Group 2 consisting of 14 patients was treated with flutter along conventional CPT. Pre- and post-physiotherapy PEFR was noted. Results: The data were analyzed using a paired and unpaired t-test, and there was significant improvement seen in Group 2 as compared to Group 1 (P < 0.001). Conclusion: Flutter device should be amalgamated as a routine practice along with other CPT techniques in CABG patients which can have positive results in airway clearance and thereby improving PEFR.
背景:冠状动脉搭桥术(CABG)广泛用于治疗心脏病患者。由于这是一项涉及胸腔的大手术,术后肺功能可能会受损。冠状动脉旁路移植术后的肺功能障碍是不可避免的。胸部理疗(CPT)是一种预防术后肺部并发症的治疗方法。Flutter是一种与高频振荡相结合的呼气正压装置;它为患者提供了独立性,并且易于用于气道清除。目的:研究扑动联合常规CPT对CABG患者呼气峰流速(PEFR)的影响。方法:通过简单随机抽样选择27名冠状动脉搭桥术患者,并将其分为两组。由13名患者组成的第1组接受了常规CPT治疗,而由14名患者构成的第2组接受了传统CPT的扑动治疗。注意物理治疗前后的PEFR。结果:使用配对和非配对t检验对数据进行分析,与第1组相比,第2组有显著改善(P<0.001)。
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引用次数: 0
A study to assess the effectiveness of audiovisual education on mirror therapy exercises among hospitalized stroke patients at a tertiary care hospital of south indian town 一项评估在南印度镇一家三级保健医院住院的中风患者中进行镜像治疗练习的视听教育效果的研究
IF 0.3 Pub Date : 2023-05-01 DOI: 10.4103/jss.jss_168_22
D. Ramaswamy, S. Parimala
Background: Hemiplegia, which means paralysis of one side of the body, is one of the most common and debilitating effects of a stroke. Stroke is a leading cause of permanent disability in adults. It is estimated that there will be 23 million new cases of strokes and 8 million stroke deaths in 2030. Mirror therapy (MT), in addition to a traditional rehabilitation program, was found to be useful in terms of motor recovery and upper limb function. Materials and Methods: The current study aimed at assessing the effect of audiovisual education on MT exercises among the hospitalized stroke patients. A quasi-experimental design was adopted in this study, where the audiovisual education was given to the experimental group, whereas routine treatment was given to the control group. Results: The result shows that in the experimental group, the majority (40%; n = 6) of the patients belonged to the age group of 61–70 years, whereas in the control group, majority (33.3%; n = 5) of the patients belonged to the age group of 51–60 years and 61–70 years. Majority (60%) of the patients in this study were male. Conclusion: MT exercises were found to be an effective, low-cost, and nonpharmacological method of lowering pain in stroke patients in the hospital.
背景:偏瘫是指身体一侧瘫痪,是中风最常见和最使人衰弱的影响之一。中风是导致成年人永久残疾的主要原因。据估计,到2030年,将有2300万新的中风病例和800万中风死亡病例。除了传统的康复计划外,镜像疗法(MT)在运动恢复和上肢功能方面也很有用。材料和方法:本研究旨在评估视听教育对住院脑卒中患者MT运动的影响。本研究采用准实验设计,实验组接受视听教育,对照组接受常规治疗。结果:实验组中,大多数(40%;n=6)患者属于61-70岁年龄组,而对照组中,大部分(33.3%;n=5)患者属于51-60岁和61-700岁年龄组。本研究中的大多数(60%)患者为男性。结论:MT运动是一种有效、低成本、非药物的降低脑卒中患者疼痛的方法。
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引用次数: 0
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