A. Lachyan, V. Singh, Swati Verma, Debashish Paramanick
Many people who have recovered from coronavirus disease 2019 (COVID-19) have recently been diagnosed with black fungus – or mucormycosis – disease. Rhino-orbital mucormycosis is becoming more common in people with COVID-19, particularly in India. On its own, diabetes mellitus is a risk factor for severe COVID-19 and mucormycosis. The goal of this study is to conduct a review of the literature to determine the features of patients with mucormycosis and COVID-19. Increased mucormycosis in India appears to be the result of an unholy trifecta of diabetes (high hereditary incidence), corticosteroid overuse (increased blood glucose and opportunistic fungal infection), and COVID-19 (cytokine storm, lymphopenia, and endothelial damage). To limit the incidence of deadly mucormycosis, all efforts should be made to maintain optimum hyperglycemia, and only prudent evidence-based use of corticosteroids in patients with COVID-19 is advocated. In this review, we emphasize knowledge on diagnosis and therapy regarding black fungal mucormycosis, which is accompanied by post-SARS-CoV-2.
{"title":"A short review on black fungal mucormycosis accompanied by Post-SARS-CoV-2","authors":"A. Lachyan, V. Singh, Swati Verma, Debashish Paramanick","doi":"10.4103/jss.jss_86_21","DOIUrl":"https://doi.org/10.4103/jss.jss_86_21","url":null,"abstract":"Many people who have recovered from coronavirus disease 2019 (COVID-19) have recently been diagnosed with black fungus – or mucormycosis – disease. Rhino-orbital mucormycosis is becoming more common in people with COVID-19, particularly in India. On its own, diabetes mellitus is a risk factor for severe COVID-19 and mucormycosis. The goal of this study is to conduct a review of the literature to determine the features of patients with mucormycosis and COVID-19. Increased mucormycosis in India appears to be the result of an unholy trifecta of diabetes (high hereditary incidence), corticosteroid overuse (increased blood glucose and opportunistic fungal infection), and COVID-19 (cytokine storm, lymphopenia, and endothelial damage). To limit the incidence of deadly mucormycosis, all efforts should be made to maintain optimum hyperglycemia, and only prudent evidence-based use of corticosteroids in patients with COVID-19 is advocated. In this review, we emphasize knowledge on diagnosis and therapy regarding black fungal mucormycosis, which is accompanied by post-SARS-CoV-2.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"139 - 146"},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48474750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Prasad, J. Sankar, D. Govindan, K. Priyadharsini
Background: Postoperative pain and its management are a budding specialty in the medical field. The additions of adjuvants to local anesthetics were one of the effective methods to improve postoperative analgesia in terms of duration and profile. The study was done primarily to assess the duration of analgesia in terms of pain score and total analgesic requirement among fentanyl and clonidine. Materials and Methods: The study was a double-blinded randomized control trial among 72 pediatric subjects where the subjects were randomly allocated into: Fentanyl group: received 0.75 ml/kg ropivacaine 0.2% along with fentanyl 1 μg/kg, clonidine group received 0.75 ml/kg ropivacaine 0.2% along with clonidine 1 μg/kg and ropivacaine alone group received 0.75 ml/kg 0.2% ropivacaine alone. Pain was assessed by objective pain scale score and Ramsay Sedation Scale was used to assess postoperative sedation. The data were entered into Microsoft Excel and analyzed using SPSS 16. Results: Clonidine group showed bradycardia and hypotension intraoperatively and postoperatively as compared to the other groups (P < 0.05). Both the fentanyl and clonidine group showed increased sedation (3.13 [0.34] vs. 2.13 [0.54] and 1.96 [0.36]) longer duration of analgesia (15.50 [1.35], 11.67 [3.71] and 9.17 [1.86]) and lesser pain score compared to the placebo group (P < 0.05). Among the groups, clonidine showed a better profile. Conclusion: The study concluded that both fentanyl and clonidine as an adjuvant to ropivacaine showed longer duration of analgesia with increased sedation score and lesser pain score. Clonidine showed a better profile in terms of duration of analgesia, pain, and sedation.
{"title":"Efficacy of fentanyl versus clonidine as an adjuvant to ropivacaine compared to ropivacaine for postoperative analgesia in caudal block for infraumblical pediatric surgeries: A prospective double-blinded randomized control study","authors":"T. Prasad, J. Sankar, D. Govindan, K. Priyadharsini","doi":"10.4103/jss.jss_192_22","DOIUrl":"https://doi.org/10.4103/jss.jss_192_22","url":null,"abstract":"Background: Postoperative pain and its management are a budding specialty in the medical field. The additions of adjuvants to local anesthetics were one of the effective methods to improve postoperative analgesia in terms of duration and profile. The study was done primarily to assess the duration of analgesia in terms of pain score and total analgesic requirement among fentanyl and clonidine. Materials and Methods: The study was a double-blinded randomized control trial among 72 pediatric subjects where the subjects were randomly allocated into: Fentanyl group: received 0.75 ml/kg ropivacaine 0.2% along with fentanyl 1 μg/kg, clonidine group received 0.75 ml/kg ropivacaine 0.2% along with clonidine 1 μg/kg and ropivacaine alone group received 0.75 ml/kg 0.2% ropivacaine alone. Pain was assessed by objective pain scale score and Ramsay Sedation Scale was used to assess postoperative sedation. The data were entered into Microsoft Excel and analyzed using SPSS 16. Results: Clonidine group showed bradycardia and hypotension intraoperatively and postoperatively as compared to the other groups (P < 0.05). Both the fentanyl and clonidine group showed increased sedation (3.13 [0.34] vs. 2.13 [0.54] and 1.96 [0.36]) longer duration of analgesia (15.50 [1.35], 11.67 [3.71] and 9.17 [1.86]) and lesser pain score compared to the placebo group (P < 0.05). Among the groups, clonidine showed a better profile. Conclusion: The study concluded that both fentanyl and clonidine as an adjuvant to ropivacaine showed longer duration of analgesia with increased sedation score and lesser pain score. Clonidine showed a better profile in terms of duration of analgesia, pain, and sedation.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"226 - 234"},"PeriodicalIF":0.3,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44296363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prabhakar Adake, Mahalaxmi S. Petimani, K. Gourav, A. Balakrishna
Objectives: The objective of this study is to assess and correlate adverse drug events following coronavirus disease (COVID) vaccination with blood group and dietary style. Methodology: This is a cross-sectional study carried out from May 2021 to July 2021. A prevalidated Google questionnaire containing demographic details, dietary style, blood group, preexisting diseases, and adverse events of the COVID vaccine was circulated to all health-care professionals of our institution through mail/WhatsApp. Informed consent was obtained (in Google Forms) from all the participants after describing the purpose of the study and the assurance to maintain anonymity and confidentiality. A total of 102 responses were collected, out of which 100 (n = 100) responses were analyzed and interpreted (two responses were excluded since participants are not vaccinated). The descriptive statistical method is applied for the assessment of adverse events. The Chi-square test is applied to assess the correlation between adverse events with blood group and dietary style. P < 0.05 is considered statistically significant. Results: The majority of the participants had comorbidities (80%) and were not infected with COVID (90%) before vaccination. Pain at the injection site is very frequently experienced followed by body aches, fatigue, fever, and weakness of the arm. The Chi-square correlation test showed that nonvegetarians had a significantly higher incidence of pain at the injection site compared to vegetarians [χ2 = 7.799, P < 0.004]. However, the study did not find a significant association between other adverse events with blood group and dietary style of the participants (P > 0.05). Conclusion: The present study concludes that study participants experienced minor adverse events following Covishield and Covaxin; pain at the injection site, myalgia, and fever are more frequent. Moreover, there is a higher incidence of injection site pain in nonvegetarians compared to vegetarians. However, there is no significant association between other adverse events with blood group and dietary style of the participants.
{"title":"Assessment and Correlation of Adverse Events Following Coronavirus Disease Vaccination with Blood Group and Dietary Style","authors":"Prabhakar Adake, Mahalaxmi S. Petimani, K. Gourav, A. Balakrishna","doi":"10.4103/jss.jss_159_22","DOIUrl":"https://doi.org/10.4103/jss.jss_159_22","url":null,"abstract":"Objectives: The objective of this study is to assess and correlate adverse drug events following coronavirus disease (COVID) vaccination with blood group and dietary style. Methodology: This is a cross-sectional study carried out from May 2021 to July 2021. A prevalidated Google questionnaire containing demographic details, dietary style, blood group, preexisting diseases, and adverse events of the COVID vaccine was circulated to all health-care professionals of our institution through mail/WhatsApp. Informed consent was obtained (in Google Forms) from all the participants after describing the purpose of the study and the assurance to maintain anonymity and confidentiality. A total of 102 responses were collected, out of which 100 (n = 100) responses were analyzed and interpreted (two responses were excluded since participants are not vaccinated). The descriptive statistical method is applied for the assessment of adverse events. The Chi-square test is applied to assess the correlation between adverse events with blood group and dietary style. P < 0.05 is considered statistically significant. Results: The majority of the participants had comorbidities (80%) and were not infected with COVID (90%) before vaccination. Pain at the injection site is very frequently experienced followed by body aches, fatigue, fever, and weakness of the arm. The Chi-square correlation test showed that nonvegetarians had a significantly higher incidence of pain at the injection site compared to vegetarians [χ2 = 7.799, P < 0.004]. However, the study did not find a significant association between other adverse events with blood group and dietary style of the participants (P > 0.05). Conclusion: The present study concludes that study participants experienced minor adverse events following Covishield and Covaxin; pain at the injection site, myalgia, and fever are more frequent. Moreover, there is a higher incidence of injection site pain in nonvegetarians compared to vegetarians. However, there is no significant association between other adverse events with blood group and dietary style of the participants.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"61 - 65"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43628438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The best oils for cooking","authors":"Anita Teli","doi":"10.4103/jss.jss_103_22","DOIUrl":"https://doi.org/10.4103/jss.jss_103_22","url":null,"abstract":"","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"134 - 135"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46779955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kudachi, A. Hogade, S. Koppad, R. Mudhol, S. Javali
Objective: Preventive/regular health checkups have gained prominence over the past decade due to lifestyle-associated risks. The association of physical health checkups and mental health with “well-being,” remains unclear. Most of the time less attention is given to psychological health and its importance in physical health and disease. Patients with chronic illness may encounter irreversible changes in health status and may lead to mortality. This is closely related to psychological distress and approximately 6%–34% of the patients with chronic illness developed depression. The objective of the present study is to find the correlation between the psychological well-being and chronic disease of people attending the executive health checkup. Materials and Methods: A cross-sectional study was conducted in tertiary care hospital at Belagavi. The study enrolled 768 individuals based on 52% prevalence of hypertension reporting for an executive health checkup and evaluated their demographic profile and adapted “The Scales of Psychological Well-Being” SPARQ tool of (18 items) questionnaire. Results: The mean age of the participants was 67.06 ± 32.94 years and a M: F ratio was 2:1. Multiple linear regression equation of psychological wellbeing of patients (Y) in terms of parameters of chronic diseases was found to be under psychological wellbeing (Y) =331.1862-0.1378 BMI-0.0368SBP-0.7161DBP-0.2030 FBS + 0.2727 PPBS-30.8144 HBA1C-0.0682 cholesterol. Conclusions: There is a significant and negative relationship between psychological well-being with parameters of chronic diseases.
{"title":"Correlation between psychological well-being of people with chronic diseases in executive health checkup","authors":"A. Kudachi, A. Hogade, S. Koppad, R. Mudhol, S. Javali","doi":"10.4103/jss.jss_124_22","DOIUrl":"https://doi.org/10.4103/jss.jss_124_22","url":null,"abstract":"Objective: Preventive/regular health checkups have gained prominence over the past decade due to lifestyle-associated risks. The association of physical health checkups and mental health with “well-being,” remains unclear. Most of the time less attention is given to psychological health and its importance in physical health and disease. Patients with chronic illness may encounter irreversible changes in health status and may lead to mortality. This is closely related to psychological distress and approximately 6%–34% of the patients with chronic illness developed depression. The objective of the present study is to find the correlation between the psychological well-being and chronic disease of people attending the executive health checkup. Materials and Methods: A cross-sectional study was conducted in tertiary care hospital at Belagavi. The study enrolled 768 individuals based on 52% prevalence of hypertension reporting for an executive health checkup and evaluated their demographic profile and adapted “The Scales of Psychological Well-Being” SPARQ tool of (18 items) questionnaire. Results: The mean age of the participants was 67.06 ± 32.94 years and a M: F ratio was 2:1. Multiple linear regression equation of psychological wellbeing of patients (Y) in terms of parameters of chronic diseases was found to be under psychological wellbeing (Y) =331.1862-0.1378 BMI-0.0368SBP-0.7161DBP-0.2030 FBS + 0.2727 PPBS-30.8144 HBA1C-0.0682 cholesterol. Conclusions: There is a significant and negative relationship between psychological well-being with parameters of chronic diseases.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"102 - 107"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49281431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three-dose COVID-19 Vaccine for hemodialysis patient: Expected usefulness","authors":"B. Joob, V. Wiwanitkit","doi":"10.4103/jss.jss_161_21","DOIUrl":"https://doi.org/10.4103/jss.jss_161_21","url":null,"abstract":"","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"133 - 133"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41375850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pearl Konikkara, B. Sahoo, Debkumar Pal, M. Taywade
The major purpose of posting MBBS students in community medicine is to understand the ground realities of different existing problems leading to the disease. The students chalk out possible solutions using the available resources and transform the solution to an intervention explicitly designed for the family or individual. Family Health Advisory Services provides a platform to learn the above intent, make family visits in the community, reach a community diagnosis associated with various prevailing and contributing factors, and finally formulate a structured and specific elucidation to root out the disease or health condition. The village visit during the posting in the department of community medicine is crucial for making the preventive and promotive steps before the arrival of ill-health conditions. It also thrills the motive of different schemes and programs by state and central government in their approach and consequence if appropriately and adequately implemented in the anticipated circumstance and situation. The current article explores how a student utilizes community posting to go deep into a family's running and prevailing problems, identify the responsible and probable causes, and find a feasible and possible solution concerning the family's affordability, accessibility, and acceptability.
{"title":"Theory and practice of learning through the family adaptation and field visits in medical school: A reflective perspective","authors":"Pearl Konikkara, B. Sahoo, Debkumar Pal, M. Taywade","doi":"10.4103/jss.jss_198_22","DOIUrl":"https://doi.org/10.4103/jss.jss_198_22","url":null,"abstract":"The major purpose of posting MBBS students in community medicine is to understand the ground realities of different existing problems leading to the disease. The students chalk out possible solutions using the available resources and transform the solution to an intervention explicitly designed for the family or individual. Family Health Advisory Services provides a platform to learn the above intent, make family visits in the community, reach a community diagnosis associated with various prevailing and contributing factors, and finally formulate a structured and specific elucidation to root out the disease or health condition. The village visit during the posting in the department of community medicine is crucial for making the preventive and promotive steps before the arrival of ill-health conditions. It also thrills the motive of different schemes and programs by state and central government in their approach and consequence if appropriately and adequately implemented in the anticipated circumstance and situation. The current article explores how a student utilizes community posting to go deep into a family's running and prevailing problems, identify the responsible and probable causes, and find a feasible and possible solution concerning the family's affordability, accessibility, and acceptability.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"125 - 128"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46605633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The process of medical education delivery has evolved constantly considering the rapid progress in the field of medical sciences, and the varied roles expected of a health-care professional. The current review has been done to explore the role of virtual reality in medical education, and to identify the potential challenges and the suggestions that can aid in the successful introduction of the same in the undergraduate teaching period. An extensive search of all materials related to the topic was carried out in the PubMed search engine, and a total of 23 articles were selected based on their suitability with the current review objectives and analyzed. Keywords used in the search include virtual reality and medical education in the title alone only. Virtual reality is a kind of dynamic and adaptive learning and has been associated with multiple benefits that extend much beyond what is being offered by conventional teaching. Regardless of the multiple benefits, we must realize that it should be used to keep the intended learning outcomes in mind, so as to ensure that it can be integrated into the curriculum effectively. In conclusion, the tool of virtual reality has all the potential to transform medical education delivery in the coming days. Since virtual reality advocates principles of adult learning and gives them a platform to apply their knowledge to practice and subsequently improve on, it is quite necessary that all the medical colleges look to introduce the same within their setup and integrate it with conventional learning.
{"title":"Virtual reality in medical institutions: Innovative tool to strengthen the process of delivery of medical education","authors":"S. Shrivastava, P. Shrivastava","doi":"10.4103/jss.jss_159_21","DOIUrl":"https://doi.org/10.4103/jss.jss_159_21","url":null,"abstract":"The process of medical education delivery has evolved constantly considering the rapid progress in the field of medical sciences, and the varied roles expected of a health-care professional. The current review has been done to explore the role of virtual reality in medical education, and to identify the potential challenges and the suggestions that can aid in the successful introduction of the same in the undergraduate teaching period. An extensive search of all materials related to the topic was carried out in the PubMed search engine, and a total of 23 articles were selected based on their suitability with the current review objectives and analyzed. Keywords used in the search include virtual reality and medical education in the title alone only. Virtual reality is a kind of dynamic and adaptive learning and has been associated with multiple benefits that extend much beyond what is being offered by conventional teaching. Regardless of the multiple benefits, we must realize that it should be used to keep the intended learning outcomes in mind, so as to ensure that it can be integrated into the curriculum effectively. In conclusion, the tool of virtual reality has all the potential to transform medical education delivery in the coming days. Since virtual reality advocates principles of adult learning and gives them a platform to apply their knowledge to practice and subsequently improve on, it is quite necessary that all the medical colleges look to introduce the same within their setup and integrate it with conventional learning.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"23 - 27"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42441131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patient-reported outcome measures (PROMs) are increasingly being used in the field of physiotherapy. In India, they are primarily used to determine clinical improvement in patients following intervention or for clinical audit purposes. However, clinical, academic, and research professionals' understanding of the construct, development, and psychometric validation of PROMs are uncertain, on the darker side, and unclear. As a result, this state could potentially lead to significant constraints in practice in terms of proper PROM selection, application, and administration. Furthermore, the lack of availability of PROMs in the patients' native language may necessitate a cross-cultural approach.
{"title":"The cross-cultural adaptation process of a patient-reported outcome measure","authors":"T. Alagappan","doi":"10.4103/jss.jss_136_21","DOIUrl":"https://doi.org/10.4103/jss.jss_136_21","url":null,"abstract":"Patient-reported outcome measures (PROMs) are increasingly being used in the field of physiotherapy. In India, they are primarily used to determine clinical improvement in patients following intervention or for clinical audit purposes. However, clinical, academic, and research professionals' understanding of the construct, development, and psychometric validation of PROMs are uncertain, on the darker side, and unclear. As a result, this state could potentially lead to significant constraints in practice in terms of proper PROM selection, application, and administration. Furthermore, the lack of availability of PROMs in the patients' native language may necessitate a cross-cultural approach.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"13 - 18"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45622387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Modern anesthesia practice utilizes preemptive analgesia for providing pain relief postoperatively using oral drugs such as pregabalin and gabapentin which are otherwise used for chronic pain management. We aimed to determine which among the two is more proficient. Materials and Methods: This randomized double-blinded control study was done among 72 subjects undergoing lower abdominal surgeries under the subarachnoid block and they were randomly divided into three groups: Group 1 received a single dose of tablet pregabalin 150 mg orally, Group 2 received tablet gabapentin 600 mg orally, and Group 3 received placebo drug orally (tablet B-complex) 2 h before subarachnoid block. Pain scores, time of 1st rescue analgesic, total number of rescue analgesics, sedation score, and occurrence of side effects were also noted for 24 h. The data were analyzed using SPSS 16 with Chi-square/Fisher's exact test or analysis of variance/Kruskal–Wallis test. A statistically significant difference was considered when P < 0.05. Results: Pain scores were lesser in Group 1 and 2 except at 2nd h. Total rescue analgesic time among maximum subjects in Group 1 was 4 h 30 min, in Group 2 was 3 h 30 min and 4 h, whereas in Group 3 was 3 h (P < 0.001). The total dose of analgesics in the first 24 h was 2 doses in Group 1, 2 doses in Group 2, and 3 doses in Group 3 (P < 0.001). Sedation score was more on Group 1 and 2 in comparison to Group 3 with no side effects in all groups. Conclusions: We conclude that pregabalin to be the effective preemptive drug because of its lesser pain intensity scores and good sedation property.
{"title":"A randomized trial comparing the efficacy of oral preemptive pregabalin and gabapentin for postoperative analgesia","authors":"T. Prasad, Pavithra Prabu, K. Priyadharsini","doi":"10.4103/jss.jss_182_22","DOIUrl":"https://doi.org/10.4103/jss.jss_182_22","url":null,"abstract":"Background: Modern anesthesia practice utilizes preemptive analgesia for providing pain relief postoperatively using oral drugs such as pregabalin and gabapentin which are otherwise used for chronic pain management. We aimed to determine which among the two is more proficient. Materials and Methods: This randomized double-blinded control study was done among 72 subjects undergoing lower abdominal surgeries under the subarachnoid block and they were randomly divided into three groups: Group 1 received a single dose of tablet pregabalin 150 mg orally, Group 2 received tablet gabapentin 600 mg orally, and Group 3 received placebo drug orally (tablet B-complex) 2 h before subarachnoid block. Pain scores, time of 1st rescue analgesic, total number of rescue analgesics, sedation score, and occurrence of side effects were also noted for 24 h. The data were analyzed using SPSS 16 with Chi-square/Fisher's exact test or analysis of variance/Kruskal–Wallis test. A statistically significant difference was considered when P < 0.05. Results: Pain scores were lesser in Group 1 and 2 except at 2nd h. Total rescue analgesic time among maximum subjects in Group 1 was 4 h 30 min, in Group 2 was 3 h 30 min and 4 h, whereas in Group 3 was 3 h (P < 0.001). The total dose of analgesics in the first 24 h was 2 doses in Group 1, 2 doses in Group 2, and 3 doses in Group 3 (P < 0.001). Sedation score was more on Group 1 and 2 in comparison to Group 3 with no side effects in all groups. Conclusions: We conclude that pregabalin to be the effective preemptive drug because of its lesser pain intensity scores and good sedation property.","PeriodicalId":55681,"journal":{"name":"Journal of the Scientific Society","volume":"50 1","pages":"39 - 44"},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42809504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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