Journal of Herbal Medicine最新文献_第10页

Ethnomedicinal Plants Used for Skin Care in Sirmour District of Himachal Pradesh (India) 喜马偕尔邦Sirmour地区用于皮肤护理的民族药用植物（印度）

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-26 DOI: 10.1016/j.hermed.2025.101004

Parul Singhal , Preeti Dobhal

Introduction

The study aimed to explore the Indigenous knowledge regarding the utilisation of medicinal plants for curing skin diseases in rural pockets of Sirmour district of Himachal Pradesh as the study area was unexplored till date. The main purpose of the study is to unfold the asset of traditional medicinal plants and make it accessible to others for further usage.

Methods

Facts on ethnomedicinal plants were recorded after the intensive field visits and surveys of 390 households of 69 villages using semistructured interviews and group discussions by standard questionnaires. All the collected data were analysed by informant consensus factor, fidelity level, use value, and relative frequency citation.

Results

The current research reported 73 ethnomedicinal plants of 39 families being utilised in skin cure. Maximum used method of preparation includes poultice (44.16%) while the utmost plants are used for curing injuries, cuts, and wounds (27%). The highest informant consensus factor value 0.93 was reported for ringworm disease. The highest fidelity level was reported for Euphorbia hirta (77.63%). In the study, 18 plants for curing skin ailments were reported for the first time.

Conclusions

These findings indicate that utilisation of Indigenous traditional herbal medicine is a well-established practice in Sirmour district to explore the original vicinity. However, plants were reported to be used unsustainably. The observation generated by this research creates scientific curiosity regarding further studies to assess the efficacy with modern assays, which will provide substantive benefits to society.

该研究旨在探索关于利用药用植物治疗喜马偕尔邦Sirmour地区农村地区皮肤病的土著知识，因为该研究地区迄今尚未开发。本研究的主要目的是揭示传统药用植物的价值，并使其可供他人进一步利用。方法采用半结构化访谈法和标准问卷小组讨论法，对69个村390户居民进行深入的实地调查和调查，记录民族药材的情况。对收集到的所有数据进行信息者共识因子、保真度、使用价值和相对被引频次分析。结果本研究报道了39科73种民族药用植物用于皮肤治疗。最常用的制备方法是膏药（44.16%），而最常用的植物是用于治疗受伤、割伤和伤口（27%）。据报道，癣病的最高知情者共识因子值为0.93。大戟（Euphorbia hirta）保真度最高（77.63%）。在这项研究中，首次报道了18种治疗皮肤病的植物。结论利用土着传统草药是西摩地区探索原始地区的一种行之有效的做法。然而，据报道，植物的使用是不可持续的。这项研究产生的观察结果引起了科学好奇心，人们对进一步研究以现代分析方法评估其功效产生了好奇心，这将为社会带来实质性的好处。

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引用次数: 0

An updated review on ethnobotanical insights, phytochemistry and pharmacological potentials of Homalomena aromatica Schott.: an important medicinal aromatic plant 香茉莉民族植物学、植物化学和药理潜力的最新研究进展。重要的药用芳香植物

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1016/j.hermed.2025.100995

Raghu Tamang , Tanmita Gupta , Twahira Begum , Mohan Lal

Introduction

Homalomena aromatica Schott., a member of Araceae family, is considered pivotal in both medicinal and aromatic purposes used by aromatic and perfumery industries throughout world. In the present review we have highlighted the ethnobotany, phytochemistry as well as biological activities with future pharmacological aspects of this medicinal species.

Methods

An extensive literature review was searched from Google Scholar, PubChem, Sciencedirect, Wiley online library and followed the PRISMA (2020) guidelines. The key words searched include H. aromatica, essential oil, pharmacological properties, biological activity and ethnobotany.

Results

H. aromatica essential oil contains many important chemical constituents which includes linalool followed by terpinene-4 ol, α-terpinol, γ-terpine, α-cadinol, τ-cadinol, spathulenol, geraniol, nerol, etc. The residual material remaining after extracting essential oil finds extensive use in the production of incense (dhup). In addition to its aromatic qualities, the plant harbours medicinal attributes beneficial for treating a myriad of ailments. The rhizomes and leaves are frequently employed to alleviate pain and combat skin infections. Furthermore, the plant boasts diverse pharmacological properties including antispasmodic, antifungal, analgesic, antidepressant, sedative, anti-inflammatory activities.

Conclusion

This review offers a summary of the chemical composition and pharmacological applications of H. aromatica. Additionally, it sheds light on the plant's ethnobotanical uses, economic prospects, and potential avenues for future research in its diverse pharmacological applications.

【导语】香茄。作为天南星科的一员，它被认为是世界各地芳香和香料工业的药用和芳香用途的关键。在本综述中，我们重点介绍了该药用物种的民族植物学、植物化学以及生物活性与未来药理学方面的研究进展。方法根据PRISMA（2020）指南，从谷歌Scholar、PubChem、Sciencedirect、Wiley在线图书馆中检索大量文献。检索到的关键词包括胡麻、挥发油、药理特性、生物活性和民族植物学。芳香树精油含有多种重要的化学成分，依次为芳樟醇、松油烯-4醇、α-松油醇、γ-松油醇、α-二醇、τ-二醇、鸡皮酚、香叶醇、薄荷醇等。提取精油后剩下的残余物质广泛用于制作香（dhup）。除了芳香外，这种植物还具有治疗多种疾病的药用价值。根茎和叶子经常被用来减轻疼痛和对抗皮肤感染。此外，该植物具有多种药理特性，包括抗痉挛，抗真菌，镇痛，抗抑郁，镇静，抗炎活性。结论综述了香茅属植物的化学成分及药理应用。此外，它还揭示了该植物的民族植物学用途，经济前景以及未来研究其多种药理应用的潜在途径。

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引用次数: 0

Natural Products in Leukaemia Research: A Bibliometric Review 白血病研究中的天然产物：文献计量学综述

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1016/j.hermed.2025.100993

Siddig Ibrahim Abdelwahab , Manal Mohamed Elhassan Taha , Syam Mohan

Introduction

This study evaluated the available literature concerning the diverse aspects of natural product activity against leukaemia.

Methods

Bibliometric data were obtained from the Scopus bibliographic database through search phrases developed from the MeSH database. Statistical analysis of the data was performed via Bibliometerix and VOSviewer. The search query was constructed on the basis of MeSH terms (D010936, D064209, and D007938) for the major topics. The data were further examined via bibliometric software tools such as Bibliometerix and VOSviewer.

Results

This bibliometric assessment covered original scientific articles from 1961 to 2023 in 1 039 journals and 4 704 documents with positive trends, which suggested a polynomial regression fit of the data (R² = 0.9346). The most active researcher is T. Efferth (Germany). The most advanced, cited, and collaborative nation is the United States. The key themes identified include ‘apoptosis,’ ‘cancer,’ ‘cytotoxicity,’ ‘HL-60 cells,’ and ‘Bcl-2.’ Thematic evolution reveals a shift toward emerging areas such as ‘molecular docking’ and ‘network pharmacology.’

Conclusions

These findings provide critical insights into research trends and highlight the evolving focus within leukaemia-related natural product studies, offering directions for future advancements.

本研究评估了有关天然产物抗白血病活性的各个方面的现有文献。方法文献计量学数据从Scopus书目数据库中通过MeSH数据库开发的检索词获得。通过Bibliometerix和VOSviewer对数据进行统计分析。基于主要主题的MeSH术语（D010936、D064209和D007938）构建搜索查询。通过Bibliometerix和VOSviewer等文献计量软件工具进一步检查数据。结果本文献计量学评价涵盖1961 ~ 2023年1 039种期刊的原创科学论文和4 704篇正趋势文献，数据符合多项式回归拟合（R² = 0.9346）。最活跃的研究者是T. Efferth（德国）。最先进、被引用最多、最合作的国家是美国。确定的关键主题包括“细胞凋亡”、“癌症”、“细胞毒性”、“HL-60细胞”和“Bcl-2”。主题进化揭示了向“分子对接”和“网络药理学”等新兴领域的转变。这些发现为研究趋势提供了重要的见解，并突出了白血病相关天然产物研究的发展重点，为未来的发展提供了方向。

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引用次数: 0

Evaluating the Therapeutic Efficacy of Habb-e-Ghafis in Non-alcoholic Fatty Liver Disease, a Randomised, Single-Blind, Standard-Controlled Trial 评价Habb-e-Ghafis治疗非酒精性脂肪肝的疗效，一项随机、单盲、标准对照试验

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI: 10.1016/j.hermed.2024.100986

Nida Mehraj, Zaffar Hussain, Atiba Jan, Zarfah Fida

Introduction

Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder. Its emergence as a major health challenge has prompted a re-evaluation of therapeutic approaches, particularly considering the limitations associated with prevailing conventional treatments. It was hypothesized that Habb-e-Ghafis may exhibit therapeutic properties capable of ameliorating the pathological processes associated with NAFLD. The aim of the study was to evaluate the safety and efficacy of Habb-e-Ghafis in the treatment of non-alcoholic fatty liver disease.

Methods

This was a single-blind, randomised, standard-controlled clinical study. The study involved 44 non-alcoholic fatty liver disease patients, with 42 completing the trial. The study was approved by the Institutional Ethics Committee (IEC No.: RRIUMSGR/ MD-2019/CT/HG/NAFLD) on November 26, 2021, and registered with the Clinical Trials Registry-India (CTRI/2022/01/039497) on January 17, 2022. Patient recruitment commenced in March 2022 at RRIUM Hospital. The test group (22 patients) received Habb-e-Ghafis (3 pills, thrice daily) for 45 days, while the control group (22 patients) received Vitamin E (400 mg twice daily).

Results

Our study revealed the remarkable effectiveness of Habb-e-Ghafis in alleviating subjective symptoms. It significantly reduced liver span as quantified by Ultrasonography when compared to the standard medication. Concerning lipid profiles, the experimental drug notably reduced triglycerides and very low-density lipoprotein levels in comparison to the standard drug. Other lipid parameters showed similar effects in both treatment groups.

Conclusions

The results of this study suggest that Habb-e-Ghafis is more effective than the standard drug Vitamin E at reducing both subjective and objective parameters.

非酒精性脂肪性肝病（NAFLD）是一种常见的代谢紊乱。它作为一项重大健康挑战的出现促使人们重新评估治疗方法，特别是考虑到普遍的传统治疗方法的局限性。假设Habb-e-Ghafis可能表现出能够改善与NAFLD相关的病理过程的治疗特性。该研究的目的是评估Habb-e-Ghafis治疗非酒精性脂肪性肝病的安全性和有效性。方法本研究为单盲、随机、标准对照临床研究。这项研究涉及44名非酒精性脂肪肝患者，其中42人完成了试验。该研究已获机构伦理委员会（IEC No. 518）批准。： RRIUMSGR/ MD-2019/CT/HG/NAFLD)于2021年11月26日发布，并于2022年1月17日在印度临床试验注册中心（CTRI/2022/01/039497）注册。RRIUM医院于2022年3月开始招募患者。试验组（22例）服用Habb-e-Ghafis（3片，每日3次），连续45天，对照组（22例）服用维生素E （400 mg，每日2次）。结果Habb-e-Ghafis在缓解主观症状方面有显著效果。与标准药物相比，它显着减少了超声图像量化的肝跨度。关于脂质谱，与标准药物相比，实验药物显著降低了甘油三酯和极低密度脂蛋白水平。其他脂质参数在两个治疗组中表现出相似的效果。结论Habb-e-Ghafis在降低主客观参数方面均优于标准药物维生素E。

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引用次数: 0

Urtica dioica for benign prostatic hyperplasia 雄蕊荨麻疹为良性前列腺增生

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1016/j.hermed.2025.100996

Pawel Posadzki , Chuenjid Kongkaew , Edzard Ernst

Introduction

As of 2019, globally, there were 94 million prevalent cases of benign prostatic hyperplasia. This systematic review evaluates the effectiveness of Urtica dioica as a treatment of benign prostatic hyperplasia (BPH).

Methods

MEDLINE, Embase, CINAHL, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science and ClinicalTrials.gov were searched from databases inceptions to February 2024. Randomized clinical trials (RCTs) investigating Urtica dioica (with or without usual care) for treating BPH in human subjects were considered. The GRADE approach was used to evaluate the certainty of evidence.

Results

Six RCTs with a total of 1210 patients met the inclusion criteria. Risk of bias of the included studies was mostly unclear or high. Meta-analyses showed that, compared with controls (placebo, usual care), Urtica dioica improved slightly BPH symptoms measured with the International Prostate Symptom Score (IPSS) at follow-ups of up to 12 months (standardized mean difference [SMD] -2.06, 95% confidence intervals [CI] [-3.22, -0.91] very low certainty evidence), reduced prostate specific antigen (PSA) levels (mean difference [MD] -0.37 ng/ml, 95% CI [-0.50, -0.23] low certainty evidence) but the interventions had little effect on quality of life (SMD -0.59, 95% CI [-1.57, 0.38] very low certainty evidence). The main reasons for downgrading the evidence were study limitations, inconsistency, and imprecision. All six studies reported adverse-effects; stating that none had occurred.

Conclusions

There is some promising evidence to support the effectiveness of Urtica in reducing the symptoms of BPH. Future, larger and more rigorous studies might reduce the existing uncertainties.

截至2019年，全球共有9400万例良性前列腺增生。本系统综述评估了杜鹃花作为治疗良性前列腺增生（BPH）的有效性。方法检索medline、Embase、CINAHL、Cochrane Central Register of Controlled Trials （Central）、Web of Science和ClinicalTrials.gov数据库，检索时间从数据库建立到2024年2月。随机临床试验（rct）调查荨麻疹（有或没有常规护理）治疗BPH的人类受试者。GRADE方法用于评估证据的确定性。结果6项rct共1210例患者符合纳入标准。纳入研究的偏倚风险大多不明确或较高。荟萃分析显示，与对照组（安慰剂，常规护理）相比，在长达12个月的随访中，用国际前列腺症状评分（IPSS）测量的前列腺增生症状略有改善（标准化平均差[SMD] -2.06, 95%可信区间[CI][-3.22, -0.91]非常低的确定性证据），降低前列腺特异性抗原（PSA）水平(平均差[MD] -0.37 ng/ml, 95% CI [-0.50，-0.23]低确定性证据)，但干预措施对生活质量几乎没有影响（SMD -0.59, 95% CI[-1.57, 0.38]非常低确定性证据）。证据降级的主要原因是研究局限性、不一致和不精确。所有六项研究都报告了不良反应；说明没有发生任何事情。结论本品在减轻前列腺增生症状方面有一定的疗效。未来，更大规模和更严格的研究可能会减少现有的不确定性。

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引用次数: 0

Traditional herbal practices associated with malaria and symptoms: Mishmi tribe cohort study from Arunachal Pradesh, Northeast India 与疟疾和症状相关的传统草药疗法：印度东北部阿鲁纳恰尔邦米什米部落队列研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI: 10.1016/j.hermed.2025.101002

Simi Talukdar

Introduction

The Miju-Mishmi tribe of Lohit district, Arunachal Pradesh has a long-standing tradition of utilising herbal remedies for treating various ailments, including malaria. This study aimed to explore the antimalarial plants traditionally utilised by the Miju-Mishmi tribe, their preparation methods, and the biological significance of these remedies through phytopharmacological analysis.

Methods

The three villages of Karhe, Ziro Basti and Telluliang in Arunachal Pradesh were selected as study sites which spanned from April 2020 to July 2021. A group of people, including knowledgeable elders, traditional healers, herb vendors, and patients, who had been treated, were interviewed using semi-structured interviews and focus groups. In order to measure the efficacy and popularity of medicinal plants, ethnobotanical indices were computed. These included Fidelity Level, Preference Ranking, Use Value, Informant Consensus Factor, and Formulation Score.

Results and discussion

A total of 79 medicinal plants from 50 families and 71 genera, with 24 plants being newly identified for their antimalarial properties. Predominantly, leaves (30.38%) of herbaceous species (48.10%) were commonly used, with direct oral consumption being the highest preferred mode of administration (83.54%), primarily through extraction (25.81%) and decoction (22.58%). Notably, Aconitum heterophyllum demonstrated the highest fidelity value (≥80%), while Coptis teeta exhibited the highest Preference Ranking (≥65%). The Use Value index ranged from 0.07 to 0.87. Qualitative phytochemical profiling of selected plants confirmed their therapeutic efficacy against malaria.

Lohit地区的Miju-Mishmi部落**有使用草药治疗包括疟疾在内的各种疾病的悠久传统。本研究旨在通过植物药理学分析，探索Miju-Mishmi部落传统使用的抗疟植物及其制备方法，以及这些药物的生物学意义。方法于2020年4月至2021年7月，选择**省Karhe、Ziro Basti和tell梁3个村作为研究地点。一群人，包括知识渊博的长者、传统治疗师、草药供应商和接受过治疗的病人，使用半结构化访谈和焦点小组进行了采访。为了衡量药用植物的功效和普及程度，计算了民族植物学指数。这些指标包括保真度水平、偏好等级、使用价值、知情者共识因子和表述得分。结果与讨论共获得50科71属79种药用植物，其中新鉴定抗疟植物24种。以草本植物叶（30.38%）为主（48.10%），直接口服给药比例最高（83.54%），其次为提取（25.81%）和煎煮（22.58%）。其中，乌头（Aconitum heterophyllum）保真度最高（≥80%），黄连（Coptis teeta）最高（≥65%）。使用价值指数范围为0.07 ~ 0.87。所选植物的定性植物化学分析证实了它们对疟疾的治疗效果。

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引用次数: 0

Survey Exploration of Some Plants Used in Managing Hypertension in the North Central States of Nigeria 尼日利亚中北部各州用于治疗高血压的一些植物的调查探索

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1016/j.hermed.2025.100994

Otaru Audu Isah , MacDonald Idu , Ogunma Benjamin Gabriel

Introduction

This study entails surveying and documenting information on the traditional management of hypertension using medicinal plants among people in the North Central States of Nigeria.

Methods

Ethnomedicinal survey was conducted across the region using questionnaires, tape recorders and interpreters. Questionnaires were administered to 180 respondents in 200 locations. The generic and family names of each plant species were documented following authentication.

Results

Seventy-two (72) medicinal plant species belonging to 65 genera and 45 families were cited from 180 respondents of which 107 were traditional healers. Respondents reported that inheritance (104 informants) and apprenticeship (56 informants) were the two modes of indigenous knowledge acquisition. The frequency of use of each plant species as a folkloric antihypertensive agent revealed that Anacardium occidentale has the lowest use value and fidelity level (0.57, 14.29), while Moringa oleifera has the highest use value and fidelity level (0.95, 90.00), respectively. The family Rubiaceae has the highest representation of plant species (7.04%). Most plants were wild (46.48%), and herbs had the most significant representation (42.25%). The preferred mode of administration of traditional medicine was oral, and the dosage regimen was 30 ml three times daily. Most of the respondents were aged between 41 and 50.

Conclusions

This study documents antihypertensive plants used among the indigenous communities within the North Central States of Nigeria. The unevaluated plants may be a viable reservoir of alternative sources of antihypertensive drug development.

本研究需要调查和记录尼日利亚中北部各州人们使用药用植物进行高血压传统管理的信息。方法采用问卷调查、录音、口译等方式进行全国医学调查。对200个地点的180名受访者进行了问卷调查。每个植物物种的属名和科名在鉴定后被记录下来。结果180名调查对象共被引用药用植物72种，隶属于45科65属，其中传统治疗师107人。受访者报告说，继承（104名被调查者）和学徒（56名被调查者）是土著知识获取的两种模式。各植物作为民间降压药的使用频次显示，西部木的使用价值和忠实度最低（0.57,14.29），辣木的使用价值和忠实度最高（0.95,90.00）。茜草科植物的代表性最高（7.04%）。植物以野生植物为主（46.48%），草本植物最具代表性（42.25%）。中药首选给药方式为口服，给药方案为30 ml，每日3次。大多数受访者的年龄在41岁至50岁之间。结论：本研究记录了尼日利亚中北部各州土著社区中使用的抗高血压植物。未评估的植物可能是抗高血压药物开发的替代来源的可行水库。

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引用次数: 0

Anticariogenic efficacy of Indian Costus mouthwash in children 木香漱口水对儿童的抗癌作用

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1016/j.hermed.2025.100997

Ghada Salem , Maryam ElMansy , Eman Allam , Asem Anter , Rehab Abdelmonem , Mohamed Rashed

Introduction

Herbal mouthwashes have become more popular in recent years as a countermeasure to the side effects of conventional mouthwashes. The aim of this study was to investigate the anti-bacterial effect of different concentrations of newly formulated Indian Costus mouthwash against Streptococcus mutans bacteria (S. mutans).

Methods

A total of 75 children (6–13 years old) were randomly divided into five groups (n = 15) according to the type and concentration of the mouthwash as follows: group 1: negative control, tap water; group 2: positive control, chlorhexidine; group 3: 5% Indian Costus; group 4: 10% Indian Costus; group 5: 15% Indian Costus. Patients were instructed to rinse with 5 ml of the given mouthwash twice per day for 1 week. Non-stimulated saliva sample was collected before (baseline) and after 1 week of using the mouthwash. Microbiological examination was performed to assess S. mutans count in all samples. One-way ANOVA followed by Tukey post hoc test were used for statistical analysis and the significance level was set at P ≤ 0.05.

Results

Statistically significant differences were detected between baseline and post-rinse counts in all groups except for the negative control samples. The highest mean percentage of bacterial reduction was detected in group 5 (Costus 15%), whereas the lowest mean percentage of bacterial reduction was seen in group 1 (negative control, tap water).

Conclusions

This study offers preliminary evidence supporting the significant antimicrobial efficacy of Indian Costus extract mouthwash against S. mutans, a key biofilm-forming bacterium in the oral cavity.

草药漱口水近年来越来越受欢迎，作为一种对抗传统漱口水副作用的对策。本研究的目的是研究不同浓度的新配制木香漱口水对变形链球菌（S. mutans）的抗菌作用。方法将75名6 ~ 13岁儿童按漱口水种类及浓度随机分为5组（n = 15）： 1组：阴性对照，自来水；第二组：阳性对照，氯己定；第三组：5%印第安木香；第4组：10%印度木香；第5组：15%印度香树。患者被指示用5 ml给定的漱口水冲洗，每天两次，持续一周。在使用漱口水前（基线）和1周后收集非刺激唾液样本。进行微生物学检查以评估所有样品中的变形链球菌计数。采用单因素方差分析加Tukey事后检验进行统计学分析，显著性水平P≤0.05。结果除阴性对照外，各组的基线计数与冲洗后计数均有统计学差异。5组平均细菌减少率最高（Costus 15%），而1组（阴性对照，自来水）平均细菌减少率最低。结论木香树提取物漱口水对口腔内一种重要的生物膜形成细菌变形链球菌具有显著的抗菌作用。

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引用次数: 0

Efficacy of traditional Chinese medicine combined with conventional western medicine on metabolic syndrome: a Bayesian network meta-analysis 中西医结合治疗代谢综合征疗效的贝叶斯网络meta分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1016/j.hermed.2025.100998

Yi Zhang, Yixuan Fang, Nannan Xing, Pengling Ge

Introduction

Metabolic syndrome (MetS) is a cluster of multiple risk factors. The combination of traditional Chinese medicine (TCM) and conventional western medicine (CWM) shows promise in treating MetS. However, the effectiveness of different integrated treatments combining TCM and CWM for MetS remains a subject of ongoing debate.

Methods

PubMed, Cochrane Library, Embase, Web of Science, and four Chinese databases were searched. We evaluated the risk of bias and quality in the included studies, and performed a Bayesian multiple network meta-analysis.

Results

We included 30 randomised controlled trials. Meta-analysis based on Bayesian network demonstrated that the combination of Dachaihu decoction and CWM exhibited the most excellent clinical treatment efficacy on MetS. The combination of HuanglianWendan decoction + Dachaihu decoction and CWM demonstrated the most favourable impact on improving patient body mass index (BMI); the combination of Gegen Qinlian decoction + Pingwei San and CWM exhibited a significant effect in reducing patient waist circumference; among various treatment measures, Wuling San combined with CWM had been proven to be more effective in enhancing high-density lipoprotein cholesterol (HDL-c) levels in patients.

Conclusion

The combination of TCM and CWM exhibits a pronounced therapeutic efficacy in the management of MetS, surpassing the use of CWM alone. This study identified the optimal intervention strategies for different outcome indicators by combining TCM and CWM in a comprehensive manner. However, due to the limitations of this study, more high-quality studies are needed to provide robust evidence in the future.

代谢综合征（MetS）是多种危险因素的集合。中医与西医结合治疗代谢代谢综合征（MetS）具有广阔的前景。然而，中西医结合治疗MetS的不同综合治疗方法的有效性仍然是一个持续争论的主题。方法检索spubmed、Cochrane Library、Embase、Web of Science及4个中文数据库。我们评估了纳入研究的偏倚风险和质量，并进行了贝叶斯多网络meta分析。结果纳入30项随机对照试验。基于贝叶斯网络的meta分析显示，大柴胡汤联合水杨汤治疗MetS的临床疗效最优。黄连文丹汤+大柴胡汤与CWM联合用药对改善患者体质指数（BMI）的效果最为有利；葛根芩连汤+平胃散联合中药减腰围效果显著；在多种治疗措施中，五灵散联合CWM对提高患者高密度脂蛋白胆固醇（HDL-c）水平更为有效。结论中西医结合治疗MetS疗效显著，优于单用中药。本研究通过中西医结合的综合方法，确定了针对不同结局指标的最佳干预策略。然而，由于本研究的局限性，未来需要更多高质量的研究来提供有力的证据。

{"title":"Efficacy of traditional Chinese medicine combined with conventional western medicine on metabolic syndrome: a Bayesian network meta-analysis","authors":"Yi Zhang, Yixuan Fang, Nannan Xing, Pengling Ge","doi":"10.1016/j.hermed.2025.100998","DOIUrl":"10.1016/j.hermed.2025.100998","url":null,"abstract":"<div><h3>Introduction</h3><div>Metabolic syndrome (MetS) is a cluster of multiple risk factors. The combination of traditional Chinese medicine (TCM) and conventional western medicine (CWM) shows promise in treating MetS. However, the effectiveness of different integrated treatments combining TCM and CWM for MetS remains a subject of ongoing debate.</div></div><div><h3>Methods</h3><div>PubMed, Cochrane Library, Embase, Web of Science, and four Chinese databases were searched. We evaluated the risk of bias and quality in the included studies, and performed a Bayesian multiple network meta-analysis.</div></div><div><h3>Results</h3><div>We included 30 randomised controlled trials. Meta-analysis based on Bayesian network demonstrated that the combination of Dachaihu decoction and CWM exhibited the most excellent clinical treatment efficacy on MetS. The combination of HuanglianWendan decoction + Dachaihu decoction and CWM demonstrated the most favourable impact on improving patient body mass index (BMI); the combination of Gegen Qinlian decoction + Pingwei San and CWM exhibited a significant effect in reducing patient waist circumference; among various treatment measures, Wuling San combined with CWM had been proven to be more effective in enhancing high-density lipoprotein cholesterol (HDL-c) levels in patients.</div></div><div><h3>Conclusion</h3><div>The combination of TCM and CWM exhibits a pronounced therapeutic efficacy in the management of MetS, surpassing the use of CWM alone. This study identified the optimal intervention strategies for different outcome indicators by combining TCM and CWM in a comprehensive manner. However, due to the limitations of this study, more high-quality studies are needed to provide robust evidence in the future.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"50 ","pages":"Article 100998"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of milk thistle (Silybum marianum) phytochemicals as curative agents of retinoblastoma using in-silico approach 水飞蓟（Silybum marianum）植物化学物质在视网膜母细胞瘤治疗中的应用

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1016/j.hermed.2025.100992

Ayesha Yasmin , Muhammad Naveed Shahid , Usman Arif , Adil Jamal

Introduction

Retinoblastoma is a malignant tumour that primarily affects children under the age of five. This cancer arises from retinoblasts, leading to a distinctive symptom known as leukocoria, which is a white reflection visible when light shines on the retina. Retinal cells proliferate uncontrollably as a result of mutations in the allele of the retinoblastoma gene (RB1) which indirectly cause overexpression of CDK4 and CDK6 proteins. Milk thistle has the ability to inhibit cancer cell growth, prevent angiogenesis, halt metastasis, induce apoptosis, and enhance effectiveness of chemotherapy and radiation treatments.

Methods

In this study, ligands were retrieved to investigate potential of milk thistle in treating retinoblastoma and it’s in silico interaction with CDK4, CDK6, and pRb proteins were assessed through molecular docking techniques. The drug-likeness of all ligands was assessed by Lipinski rule of five. The PyMOL program was used to convert PDB format of the CDK4, CDK6, and pRb receptors into PDBQT format, and to identify active sites on the proteins. The drug-ability, lead likeness, pharmacokinetics, and physicochemical properties of ligands were assessed using SwissADME.

Results

The drug-likeness of all ligands followed Lipinski's rule with no violations of any of the five parameters. The binding affinity of milk thistle ligands to CDK4, CDK6, and pRB proteins was found to be high ranging from −3 to −9.9 kcal/mol, suggesting the potential of milk thistle as a treatment for retinoblastoma. Milk thistle is a useful treatment option for cancer, because of its anti-proliferative, anti-angiogenisis, anti- metastasis and induce apoptosis properties. ADMET analysis provided insights into the oral bioavailability, pharmacokinetics, water solubility, and physicochemical properties of the ligands.

Conclusions

The findings indicated that phytochemicals derived from milk thistle hold promising potential as a therapeutic option for retinoblastoma due to its diverse mechanisms of action, positive safety profile, and prospective synergistic effects with conventional therapies.

视网膜母细胞瘤是一种主要影响5岁以下儿童的恶性肿瘤。这种癌症起源于视网膜母细胞，导致一种被称为白斑的独特症状，当光线照射在视网膜上时，可以看到白色的反射。视网膜母细胞瘤基因（RB1）的等位基因突变间接导致CDK4和CDK6蛋白的过度表达，导致视网膜细胞不受控制地增殖。水飞蓟具有抑制癌细胞生长、阻止血管生成、阻止转移、诱导细胞凋亡、提高化疗和放疗效果等作用。方法通过分子对接技术研究水飞蓟与CDK4、CDK6、pRb蛋白之间的相互作用，并利用配体研究水飞蓟对视网膜母细胞瘤的治疗作用。所有配体的药物相似性采用Lipinski五法则进行评价。利用PyMOL程序将CDK4、CDK6和pRb受体的PDB格式转化为PDBQT格式，并鉴定蛋白上的活性位点。采用SwissADME对配体的药力、铅相似度、药代动力学和理化性质进行了评价。结果所有配体的药物相似度均符合Lipinski规则，不违反5个参数。水飞蓟配体与CDK4、CDK6和pRB蛋白的结合亲和力在−3 ~−9.9 kcal/mol之间，表明水飞蓟具有治疗视网膜母细胞瘤的潜力。水飞蓟具有抗增殖、抗血管生成、抗转移和诱导细胞凋亡等特性，是治疗癌症的有效选择。ADMET分析提供了对配体的口服生物利用度、药代动力学、水溶性和物理化学性质的见解。结论水飞蓟植物化学物质具有多种作用机制、良好的安全性以及与常规疗法的协同效应，有望成为视网膜母细胞瘤的治疗选择。

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引用次数: 0