Pub Date : 2024-04-04DOI: 10.1016/j.hermed.2024.100879
Seema B.A. Salman , Ayat A. Alrasheid
Introduction
Herbal medication has a long history of use in Sudan for various illnesses. The Corona-19 virus (COVID-19), a disease that affects the respiratory system, is the cause of the most recent global pandemic. Since there is no cure, some individuals in the Sudanese population have chosen to use herbal medication to prevent and treat symptoms of COVID-19. This study aims to assess the use of herbal medications among the Sudanese population in Khartoum for the prevention and treatment of COVID-19.
Methods
A descriptive, community-based, cross-sectional online survey was conducted on Sudanese adults over the age of 18 from June 2021 to August 2021.
Results
A total of 1012 participants from seven different localities in the state of Khartoum were included. Of the participants, 66.4% were female and 33.6% were male. Among them, 53.8% admitted to using herbal medication to prevent COVID-19. The most commonly used herbal medications for COVID-19 symptoms were Quarad (22.4%), Citrus (20.1%), Ginger (15.7%), and Black seed (11.7%). The majority of participants who contracted COVID-19 believed that herbal medication helped with the symptoms (68.4%), followed by those who thought it might have helped (28.4%). Family and friends were the main sources of knowledge about herbs. A significant association was found between the use of herbal medication and the female gender and middle-aged groups.
Conclusion
Herbal medication was commonly used in Khartoum during the pandemic.Health authorities should consider the effectiveness of herbal medication in the prevention and treatment of COVID-19.
{"title":"Exploring the efficacy of herbal medicine in the treatment and prevention of COVID-19: a study on the Sudanese population in Khartoum state","authors":"Seema B.A. Salman , Ayat A. Alrasheid","doi":"10.1016/j.hermed.2024.100879","DOIUrl":"10.1016/j.hermed.2024.100879","url":null,"abstract":"<div><h3>Introduction</h3><p>Herbal medication has a long history of use in Sudan for various illnesses. The Corona-19 virus (COVID-19), a disease that affects the respiratory system, is the cause of the most recent global pandemic. Since there is no cure, some individuals in the Sudanese population have chosen to use herbal medication to prevent and treat symptoms of COVID-19. This study aims to assess the use of herbal medications among the Sudanese population in Khartoum for the prevention and treatment of COVID-19.</p></div><div><h3>Methods</h3><p>A descriptive, community-based, cross-sectional online survey was conducted on Sudanese adults over the age of 18 from June 2021 to August 2021.</p></div><div><h3>Results</h3><p>A total of 1012 participants from seven different localities in the state of Khartoum were included. Of the participants, 66.4% were female and 33.6% were male. Among them, 53.8% admitted to using herbal medication to prevent COVID-19. The most commonly used herbal medications for COVID-19 symptoms were Quarad (22.4%), Citrus (20.1%), Ginger (15.7%), and Black seed (11.7%). The majority of participants who contracted COVID-19 believed that herbal medication helped with the symptoms (68.4%), followed by those who thought it might have helped (28.4%). Family and friends were the main sources of knowledge about herbs. A significant association was found between the use of herbal medication and the female gender and middle-aged groups.</p></div><div><h3>Conclusion</h3><p>Herbal medication was commonly used in Khartoum during the pandemic.Health authorities should consider the effectiveness of herbal medication in the prevention and treatment of COVID-19.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100879"},"PeriodicalIF":2.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to assess the effect of Citrus aurantium L. flower on the distance between two cycles, physical activity, days of bleeding, and intensity of dysmenorrhoea (primary objectives), and complications of interventions or adverse effects (secondary purpose).
Methods
This double-blind, randomised controlled clinical trial was conducted on 105 girls (15–20 years old) with primary dysmenorrhoea. In the intervention cycles, from the first to the third day, participants received 250 mg C. aurantium flower hydro-alcoholic extract capsule, Mefenamic acid (MA) capsule, or placebo three times a day based on the study groups.
Results
The results showed that the severity of dysmenorrhoea in the groups consuming C. aurantiumflower and MA was significantly lower than that before the intervention and compared to the placebo group (P< 0.001), which this reduction in the severity of pain in the C. aurantium flower group was also significantly higher than that of the MA group (P< 0.001) at the first and second days.
Conclusion
C. aurantium flower had higher efficacy and satisfaction rate and lower side effects in reducing the severity of primary dysmenorrhoea compared to MA.
目的 本研究旨在评估枳壳花对两个周期之间的距离、体力活动、出血天数和痛经强度（主要目的）以及干预并发症或不良反应（次要目的）的影响。方法 本双盲随机对照临床试验的对象是105名患有原发性痛经的女孩（15-20岁）。在干预周期内，从第一天到第三天，参与者根据研究组每天三次服用 250 毫克枳壳花水醇提取物胶囊、甲氰咪胍（MA）胶囊或安慰剂。结果结果显示，服用枳壳花和甲氰咪胍组的痛经严重程度明显低于干预前和安慰剂组（P< 0.结论与 MA 相比，枳实花在降低原发性痛经严重程度方面具有更高的疗效和满意度，副作用更低。
{"title":"The effect of Citrus aurantium L. flower extract on the severity of primary dysmenorrhoea: a double-blind, randomised, controlled clinical trial","authors":"Farkhondeh Aboualsoltani , Parvin Bastani , Laleh Khodaie , Seyyed Mohammad Bagher Fazljou , Hanieh Salehi-Pourmehr","doi":"10.1016/j.hermed.2024.100878","DOIUrl":"10.1016/j.hermed.2024.100878","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to assess the effect of <em>Citrus aurantium</em> L. flower on the distance between two cycles, physical activity, days of bleeding, and intensity of dysmenorrhoea (primary objectives), and complications of interventions or adverse effects (secondary purpose).</p></div><div><h3>Methods</h3><p>This double-blind, randomised controlled clinical trial was conducted on 105 girls (15–20 years old) with primary dysmenorrhoea. In the intervention cycles, from the first to the third day, participants received 250 mg <em>C. aurantium</em> flower hydro-alcoholic extract capsule, Mefenamic acid (MA) capsule, or placebo three times a day based on the study groups.</p></div><div><h3>Results</h3><p>The results showed that the severity of dysmenorrhoea in the groups consuming <em>C. aurantium</em>flower and MA was significantly lower than that before the intervention and compared to the placebo group (<em>P</em>< 0.001), which this reduction in the severity of pain in the <em>C. aurantium</em> flower group was also significantly higher than that of the MA group (<em>P</em>< 0.001) at the first and second days.</p></div><div><h3>Conclusion</h3><p><em>C. aurantium</em> flower had higher efficacy and satisfaction rate and lower side effects in reducing the severity of primary dysmenorrhoea compared to MA.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100878"},"PeriodicalIF":2.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study was designed to investigate the effects of Saffron supplementation on liver FibroScan test, liver enzymes, lipid profile, total and direct bilirubin, glycemic profile, and blood pressure in non-alcoholic fatty liver disease (NAFLD) patients. The researchers hypothesised that supplementation with Saffron could further improve the efficacy of lifestyle modifications in managing NAFLD.
Methods
This randomised, double-blind, placebo-controlled trial was conducted on 76 NAFLD patients, whose age range was from 18 to 65. All of them were given a specified weight loss diet and a physical activity programme. They were randomly assigned into two groups to intake 100 mg of a Saffron-coated tablet (n = 38) or a placebo tablet (n = 38) for 12 weeks. Liver FibroScan test, liver enzymes (as primary outcome), lipid profile, total and direct bilirubin, fasting blood sugar (FBS), insulin, insulin resistance (homoeostasis model assessment-insulin resistance), insulin sensitivity (quantitative insulin sensitivity check index), blood pressure, dietary intake, and physical activity were measured at baseline and also after 12 weeks. Both the participants and the dietitians were blindly assigned to the groups. Statistical analysis was carried out using SPSS software version 22.
Results
Finally, 36 patients completed the study, and 38 patients were included in the intention-to-treat analysis. Accordingly, Saffron supplementation reduced steatosis score (P > 0.001), steatosis percent (P > 0.001), steatosis stage (P > 0.001), total cholesterol (P = 0.001), triacylglycerol (P > 0.001), low-density lipoprotein (P = 0.005), and FBS (P = 0.009) more than placebo. There was no significant difference in liver fibrosis, aminotransferase (−1.33 IU/L, 95% CI = −5.10, 2.43, P = 0.482), aminotransferase (−0.20 IU/L, 95% CI = −2.94, 2.52, P = 0.880), γ-glutamyltransferase, insulin, homoeostasis model assessment-insulin resistance, and quantitative insulin sensitivity check indexes, total and direct bilirubin, and blood pressure between the two groups (P > 0.05).
Conclusions
Overall, the 12-week consumption of 100 mg Saffron, along with lifestyle modification, compared with placebo, had insignificant reducing effects on liver steatosis score, steatosis percent, steatosis stage, total cholesterol, triacylglycerol, low-density lipoprotein, and FBS among NAFLD patients. Saffron may exert considerable beneficial consequences that need further assessment in future clinical trials.
{"title":"The Effects of Saffron (Crocus sativus L) Supplementation on Cardiovascular Risk Factors, Liver Steatosis, and Fibrosis in Patients With Non-alcoholic Fatty Liver Disease: A Randomised, Double-Blind, Placebo-Controlled Study","authors":"Reyhane Sadat Mirnasrollahi Parsa , Naheed Aryaeian , Marjan Mokhtare , Farnaz Kavianipour , Leila Janani , Shahram Agah , Nariman Moradi","doi":"10.1016/j.hermed.2024.100877","DOIUrl":"10.1016/j.hermed.2024.100877","url":null,"abstract":"<div><h3>Introduction</h3><p>This study was designed to investigate the effects of Saffron supplementation on liver FibroScan test, liver enzymes, lipid profile, total and direct bilirubin, glycemic profile, and blood pressure in non-alcoholic fatty liver disease (<strong>NAFLD</strong>) patients. The researchers hypothesised that supplementation with Saffron could further improve the efficacy of lifestyle modifications in managing NAFLD.</p></div><div><h3>Methods</h3><p>This randomised, double-blind, placebo-controlled trial was conducted on 76 NAFLD patients, whose age range was from 18 to 65. All of them were given a specified weight loss diet and a physical activity programme. They were randomly assigned into two groups to intake 100 mg of a Saffron-coated tablet (n = 38) or a placebo tablet (n = 38) for 12 weeks. Liver FibroScan test, liver enzymes (as primary outcome), lipid profile, total and direct bilirubin, fasting blood sugar (<strong>FBS</strong>), insulin, insulin resistance (homoeostasis model assessment-insulin resistance), insulin sensitivity (quantitative insulin sensitivity check index), blood pressure, dietary intake, and physical activity were measured at baseline and also after 12 weeks. Both the participants and the dietitians were blindly assigned to the groups. Statistical analysis was carried out using SPSS software version 22.</p></div><div><h3>Results</h3><p>Finally, 36 patients completed the study, and 38 patients were included in the intention-to-treat analysis. Accordingly, Saffron supplementation reduced steatosis score (<em>P</em> > 0.001), steatosis percent (<em>P</em> > 0.001), steatosis stage (<em>P</em> > 0.001), total cholesterol (<em>P</em> = 0.001), triacylglycerol (<em>P</em> > 0.001), low<em>-</em>density lipoprotein (<em>P</em> = 0.005), and FBS (<em>P</em> = 0.009) more than placebo. There was no significant difference in liver fibrosis, aminotransferase (−1.33 IU/L, 95% CI = −5.10, 2.43, <em>P</em> = 0.482), aminotransferase (−0.20 IU/L, 95% CI = −2.94, 2.52, <em>P</em> = 0.880), γ-glutamyltransferase, insulin, homoeostasis model assessment-insulin resistance, and quantitative insulin sensitivity check indexes, total and direct bilirubin, and blood pressure between the two groups (<em>P</em> > 0.05).</p></div><div><h3>Conclusions</h3><p>Overall, the 12-week consumption of 100 mg Saffron, along with lifestyle modification, compared with placebo, had insignificant reducing effects on liver steatosis score, steatosis percent, steatosis stage, total cholesterol, triacylglycerol, low<em>-</em>density lipoprotein, and FBS among NAFLD patients. Saffron may exert considerable beneficial consequences that need further assessment in future clinical trials.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100877"},"PeriodicalIF":2.3,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.1016/j.hermed.2024.100875
M.G. Manzione , R. Kumar , S. Harilal , P. Mishra , K.A. Youb , P.V.T. Fokou , R. Pezzani
Introduction
Rosa canina L. is a plant of the Rosaceae family commonly known for being the ancestor of cultivated roses. It is frequently found as a wild plant in almost all the temperate areas of the Northern hemisphere, and it is used in numerous traditional medicines. R canina is used for respiratory problems, gastrointestinal diseases, kidney stones, hypertension and diabetes, osteoarthritis, and muscle and osteoarticular pain.
Methods
A literature search was performed using specific search terms, such as rose, Rosa canina, rose hip, rosehip, dog rose, wild rose, ethnopharmacology, traditional use, antioxidant, anti-inflammatory, cancer, anticancer, cytotoxicity, antiproliferative, and apoptosis. Studies on ethnotraditional and pharmacological values were retrieved as well as on isolated compounds or specific extracts on R canina.
Results
The use of R canina is based on the phytochemical profile, rich in phenolic compounds and ascorbic acid, which guarantee remarkable anti-inflammatory and antioxidant properties. Tables on phytochemical composition, phenolics and steroids, volatile compounds, and representative studies on the pharmacological activities related to cancer of R canina were reported.
Conclusions
This review analyses the phytotherapeutic properties of R canina with a specific emphasis on the anticancer effect in preclinical models, while exploring the mechanisms of action of its phytochemical compounds. In addition, this work paves the way for the exploration of the potential benefits of this plant in human oncology.
导言玫瑰（Rosa canina L.）是一种蔷薇科植物，因其是栽培玫瑰的祖先而闻名。在北半球几乎所有的温带地区，它都是常见的野生植物，并被用于多种传统医药中。方法使用特定的检索词进行文献检索，如玫瑰、蔷薇、玫瑰果、玫瑰臀、狗蔷薇、野蔷薇、民族药理学、传统用途、抗氧化剂、抗炎、癌症、抗癌、细胞毒性、抗增殖和细胞凋亡。结果 犬齿金雀花的使用基于其植物化学成分，富含酚类化合物和抗坏血酸，具有显著的抗炎和抗氧化特性。本综述分析了 R canina 的植物治疗特性，特别强调了其在临床前模型中的抗癌效果，同时探讨了其植物化学成分的作用机制。此外，这项工作还为探索这种植物在人类肿瘤学中的潜在益处铺平了道路。
{"title":"Rosa canina and Cancer: Which Evidence?","authors":"M.G. Manzione , R. Kumar , S. Harilal , P. Mishra , K.A. Youb , P.V.T. Fokou , R. Pezzani","doi":"10.1016/j.hermed.2024.100875","DOIUrl":"https://doi.org/10.1016/j.hermed.2024.100875","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Rosa canina</em> L. is a plant of the Rosaceae family commonly known for being the ancestor of cultivated roses. It is frequently found as a wild plant in almost all the temperate areas of the Northern hemisphere, and it is used in numerous traditional medicines. <em>R canina</em> is used for respiratory problems, gastrointestinal diseases, kidney stones, hypertension and diabetes, osteoarthritis, and muscle and osteoarticular pain.</p></div><div><h3>Methods</h3><p>A literature search was performed using specific search terms, such as rose, <em>Rosa canina</em>, rose hip, rosehip, dog rose, wild rose, ethnopharmacology, traditional use, antioxidant, anti-inflammatory, cancer, anticancer, cytotoxicity, antiproliferative, and apoptosis. Studies on ethnotraditional and pharmacological values were retrieved as well as on isolated compounds or specific extracts on <em>R canina</em>.</p></div><div><h3>Results</h3><p>The use of <em>R canina</em> is based on the phytochemical profile, rich in phenolic compounds and ascorbic acid, which guarantee remarkable anti-inflammatory and antioxidant properties. Tables on phytochemical composition, phenolics and steroids, volatile compounds, and representative studies on the pharmacological activities related to cancer of <em>R canina</em> were reported.</p></div><div><h3>Conclusions</h3><p>This review analyses the phytotherapeutic properties of <em>R canina</em> with a specific emphasis on the anticancer effect in preclinical models, while exploring the mechanisms of action of its phytochemical compounds. In addition, this work paves the way for the exploration of the potential benefits of this plant in human oncology.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100875"},"PeriodicalIF":2.3,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.1016/j.hermed.2024.100876
Doris Kumadoh , Hilda Amekyeh , Mary-Ann Archer , Michael O. Kyene , Genevieve N. Yeboah , Henry Brew-Daniels , Ofosua Adi-Dako , Christina Osei-Asare , Emmanuel Adase , Alfred A. Appiah
Introduction
There are no strict pH standards for herbal formulations; however, pH can affect the characteristics of drugs and herbal formulations. In this study, the pHs of different herbal formulations produced in the past two batch years at the Centre for Plant Medicine Research (Mampong-Akuapem, Ghana) were analysed. We aimed to evaluate pH consistency among the formulations and suggest suitable pH ranges for the different product classes.
Methods
The formulations analysed were 17 decoctions, three ointments, and nine powders. Suitable ointment and powder samples were prepared before pH was measured, whereas decoctions were analysed directly.
Results
We found that 93.1% of the preparations had average pH < 7 over the two years. The pH values for the decoctions, ointments, and powders were 3.507−6.755, 5.153−5.700, and 5.413−10.719, respectively. Differences in pH over the two production years were not statistically significant for all the powder and ointment formulations as well as for majority of the decoctions (82.4%). This indicates pH consistency for approximately 90% of the products, possibly pointing to consistencies in plant material compositions, formulation conditions, and process parameters.
Conclusions
From our data and reported literature, we recommend that the labels of oral herbal preparations with pH < 5.5 should include an instruction to dilute the product before intake, or to drink water or rinse the mouth after intake to prevent enamel erosion. Decoctions may also be taken after food. Additionally, pH ranges of 4.6−7.0 and 4.0−6.0 may be suitable for rectal and topical herbal formulations, respectively.
{"title":"Determination of consistency in pH of some commercial herbal formulations in Ghana","authors":"Doris Kumadoh , Hilda Amekyeh , Mary-Ann Archer , Michael O. Kyene , Genevieve N. Yeboah , Henry Brew-Daniels , Ofosua Adi-Dako , Christina Osei-Asare , Emmanuel Adase , Alfred A. Appiah","doi":"10.1016/j.hermed.2024.100876","DOIUrl":"10.1016/j.hermed.2024.100876","url":null,"abstract":"<div><h3>Introduction</h3><p>There are no strict pH standards for herbal formulations; however, pH can affect the characteristics of drugs and herbal formulations. In this study, the pHs of different herbal formulations produced in the past two batch years at the Centre for Plant Medicine Research (Mampong-Akuapem, Ghana) were analysed. We aimed to evaluate pH consistency among the formulations and suggest suitable pH ranges for the different product classes.</p></div><div><h3>Methods</h3><p>The formulations analysed were 17 decoctions, three ointments, and nine powders. Suitable ointment and powder samples were prepared before pH was measured, whereas decoctions were analysed directly.</p></div><div><h3>Results</h3><p>We found that 93.1% of the preparations had average pH < 7 over the two years. The pH values for the decoctions, ointments, and powders were 3.507−6.755, 5.153−5.700, and 5.413−10.719, respectively. Differences in pH over the two production years were not statistically significant for all the powder and ointment formulations as well as for majority of the decoctions (82.4%). This indicates pH consistency for approximately 90% of the products, possibly pointing to consistencies in plant material compositions, formulation conditions, and process parameters.</p></div><div><h3>Conclusions</h3><p>From our data and reported literature, we recommend that the labels of oral herbal preparations with pH < 5.5 should include an instruction to dilute the product before intake, or to drink water or rinse the mouth after intake to prevent enamel erosion. Decoctions may also be taken after food. Additionally, pH ranges of 4.6−7.0 and 4.0−6.0 may be suitable for rectal and topical herbal formulations, respectively.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100876"},"PeriodicalIF":2.3,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-29DOI: 10.1016/j.hermed.2024.100863
Caio Fábio Schlechta Portella , Igor De Azevedo Silva , Ricardo Santos Simões , Ricardo Ghelman , Edmund Chada Baracat , José Maria Soares Júnior , Isabel Cristina Esposito Sorpreso
Introduction
Climacteric syndrome, marking the end of a woman's reproductive years, is accompanied by a host of physical and emotional symptoms that significantly impact her quality of life. There is a growing demand for safe and effective complementary treatments due necessity of another treatment options to meet clinical needs and women's choice. This has led to a surge of interest in medicinal plants and herbal formulations, with traditional uses across cultures and emerging scientific evidence suggesting potential benefits.
Methods
A systematic overview was conducted in 2022 across five electronic databases, adhering to the standards and PRISMA guidelines. Eligibility evaluation and methodological quality assessment of studies were performed by independent reviewers using the AMSTAR2 tool.
Results
The review identified 51 medicinal plants and herbal formulations in 57 systematic reviews. Soy isoflavones, red clover extract, Hypericum perforatum preparations, black cohosh extract, and Chinese herbal medicine formulations demonstrated potential efficacy in managing climacteric symptoms.
Discussion/Conclusions
This study underscores the potential of medicinal plants and herbal formulations in managing climacteric syndrome symptoms. Notably, soy isoflavones, red clover extract, and black cohosh extract exhibited promising results. However, the current evidence base is variable, underlining the need for rigorous, well-designed research to substantiate these findings. Additionally, the intriguing results related to the reduction of sexual symptoms by Maca and Tribulus terrestris, and the potential therapeutic benefits of botanicals such as evening primrose, fenugreek, vitex, and cannabis, call for deeper investigation. This comprehensive overview serves to guide future research directions and inform clinical practice in this burgeoning field.
{"title":"An overview of systematic reviews of medicinal plants and herbal formulations for the treatment of climacteric symptoms","authors":"Caio Fábio Schlechta Portella , Igor De Azevedo Silva , Ricardo Santos Simões , Ricardo Ghelman , Edmund Chada Baracat , José Maria Soares Júnior , Isabel Cristina Esposito Sorpreso","doi":"10.1016/j.hermed.2024.100863","DOIUrl":"10.1016/j.hermed.2024.100863","url":null,"abstract":"<div><h3>Introduction</h3><p>Climacteric syndrome, marking the end of a woman's reproductive years, is accompanied by a host of physical and emotional symptoms that significantly impact her quality of life. There is a growing demand for safe and effective complementary treatments due necessity of another treatment options to meet clinical needs and women's choice. This has led to a surge of interest in medicinal plants and herbal formulations, with traditional uses across cultures and emerging scientific evidence suggesting potential benefits.</p></div><div><h3>Methods</h3><p>A systematic overview was conducted in 2022 across five electronic databases, adhering to the standards and PRISMA guidelines. Eligibility evaluation and methodological quality assessment of studies were performed by independent reviewers using the AMSTAR2 tool.</p></div><div><h3>Results</h3><p>The review identified 51 medicinal plants and herbal formulations in 57 systematic reviews. Soy isoflavones, red clover extract, <em>Hypericum perforatum</em> preparations, black cohosh extract, and Chinese herbal medicine formulations demonstrated potential efficacy in managing climacteric symptoms.</p></div><div><h3>Discussion/Conclusions</h3><p>This study underscores the potential of medicinal plants and herbal formulations in managing climacteric syndrome symptoms. Notably, soy isoflavones, red clover extract, and black cohosh extract exhibited promising results. However, the current evidence base is variable, underlining the need for rigorous, well-designed research to substantiate these findings. Additionally, the intriguing results related to the reduction of sexual symptoms by Maca and <em>Tribulus terrestris</em>, and the potential therapeutic benefits of botanicals such as evening primrose, fenugreek, vitex, and cannabis, call for deeper investigation. This comprehensive overview serves to guide future research directions and inform clinical practice in this burgeoning field.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100863"},"PeriodicalIF":2.3,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.1016/j.hermed.2024.100871
Adil Hussain
Introduction
Asteraceae is the largest flowering plant family with ∼19 11 genera and ∼32 913 species worldwide used in medicine and diet.
Methods
Data on Asteraceae flora was assembled from Google Scholar, PubMed, Medline, SciELO, Science Direct, Web of Science, books, and dissertations using specific keywords.
Results
Overall, 198 species from 78 genera of Asteraceae with traditional uses have been reported in Pakistan with Artemisia (16.6%), Launea (4%), Sassurea (4%), Conyza (3.5%), Lactuca, and Taraxacum (3%) being widely used genera. Maximum studies were reported for Artemisia from Gilgit-Baltistan and Khyber Pakhtunkhwa (KPK) following Sonchus from Punjab, Taraxamum and Xanthium from KPK. Herb was the dominant life form (86.88%) following shrubs (9.59%) and subshrubs (3.53%). Highly used plant parts include whole plant (46.96%), leaves (46.46%), and flowers (23.23%) with 12 preparation methods including decoction (64.64%), powder (29.79%), and paste (25.25%) maximally consumed orally (55%). The ethnomedicinal uses of Asteraceae were reported against ∼126 diseases specifically against gastrointestinal problems (70 species), fever (63 species), and skin diseases (50 species).
Conclusions
The baseline data from Pakistan provide comprehensive indigenous knowledge about Asteracea species against different diseases. The documentation of ethnobotany of rare species from unexplored areas of Pakistan is recommended to avoid the loss of traditional knowledge. Further toxicologic evaluation of Asteraceae species with emphasis on heavy metals profile could be a possible research line.
{"title":"Potential Medicinal Uses of Plants From the Asteraceae (Compositae) Family in Pakistan: A Literature Review Based Meta-analysis","authors":"Adil Hussain","doi":"10.1016/j.hermed.2024.100871","DOIUrl":"10.1016/j.hermed.2024.100871","url":null,"abstract":"<div><h3>Introduction</h3><p>Asteraceae is the largest flowering plant family with ∼19 11 genera and ∼32 913 species worldwide used in medicine and diet.</p></div><div><h3>Methods</h3><p>Data on Asteraceae flora was assembled from Google Scholar, PubMed, Medline, SciELO, Science Direct, Web of Science, books, and dissertations using specific keywords.</p></div><div><h3>Results</h3><p>Overall, 198 species from 78 genera of Asteraceae with traditional uses have been reported in Pakistan with <em>Artemisia</em> (16.6%), <em>Launea</em> (4%), <em>Sassurea</em> (4%), <em>Conyza</em> (3.5%), <em>Lactuca</em>, and <em>Taraxacum</em> (3%) being widely used genera. Maximum studies were reported for <em>Artemisia</em> from Gilgit-Baltistan and Khyber Pakhtunkhwa (KPK) following <em>Sonchus</em> from Punjab, <em>Taraxamum</em> and <em>Xanthium</em> from KPK. Herb was the dominant life form (86.88%) following shrubs (9.59%) and subshrubs (3.53%). Highly used plant parts include whole plant (46.96%), leaves (46.46%), and flowers (23.23%) with 12 preparation methods including decoction (64.64%), powder (29.79%), and paste (25.25%) maximally consumed orally (55%). The ethnomedicinal uses of Asteraceae were reported against ∼126 diseases specifically against gastrointestinal problems (70 species), fever (63 species), and skin diseases (50 species).</p></div><div><h3>Conclusions</h3><p>The baseline data from Pakistan provide comprehensive indigenous knowledge about Asteracea species against different diseases. The documentation of ethnobotany of rare species from unexplored areas of Pakistan is recommended to avoid the loss of traditional knowledge. Further toxicologic evaluation of Asteraceae species with emphasis on heavy metals profile could be a possible research line.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100871"},"PeriodicalIF":2.3,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.1016/j.hermed.2024.100870
P. Meenaloshini , A. Thirumurugan , P.K. Mohan , T. Senthil Kumar
Introduction
Medical research on cancer treatment is getting worldwide attention in the present day. The usage of plant sources for cancer treatment is getting much consideration because of their low toxic nature, easy availability, and with fewer side effects. This study illustrates the anticancer potential of Crateva religiosa G. Forst. extract against human ovarian cancer cells (PA-1).
Methods
Cell viability was determined using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay, and acridine orange/ethidium bromide staining techniques were used to evaluate the cell death and anticancer activity. Additionally, antioxidant activities such as hydroxyl-radical scavenging, 2,2-diphenylpicrylhydrazyl, ferric reducing ability of plasma, and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate+ were carried out. Moreover, phytochemical profiling and their quantification were also performed.
Results
The hydroalcoholic bark extract of C. religiosa has a strong anticancer prospective against PA-1 with a half-inhibitory concentration value of 33.27 μg/ml. The antioxidant potential of the extract showed potent activity on various antioxidants. The phytochemical profiling of the extract showed the presence of various phytochemicals and the quantification indicated the presence of a total phenol content of 2.1 ± 0.09 mg Gallic acid equivalent/g, total flavonoid content of 1.706 ± 0.01 mg CE/g, total alkaloid content of 1.237 ± 0.03 mg AE/g, and total terpenoid content of 1.004 ± 0.06 mg UAE/g.
Conclusions
The current findings of the study suggest the role of C. religiosa bark against human ovarian cancer cells (PA-1) and could be a potential drug source for the discovery of anticancer agents.
{"title":"In Vitro Anticancer Efficacy of Hydroalcoholic Extract From Crateva religiosa G. Forst. Bark on Human Ovarian Cancer Cells","authors":"P. Meenaloshini , A. Thirumurugan , P.K. Mohan , T. Senthil Kumar","doi":"10.1016/j.hermed.2024.100870","DOIUrl":"10.1016/j.hermed.2024.100870","url":null,"abstract":"<div><h3>Introduction</h3><p>Medical research on cancer treatment is getting worldwide attention in the present day. The usage of plant sources for cancer treatment is getting much consideration because of their low toxic nature, easy availability, and with fewer side effects. This study illustrates the anticancer potential of <em>Crateva religiosa</em> G. Forst. extract against human ovarian cancer cells (PA-1).</p></div><div><h3>Methods</h3><p>Cell viability was determined using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay, and acridine orange/ethidium bromide staining techniques were used to evaluate the cell death and anticancer activity. Additionally, antioxidant activities such as hydroxyl-radical scavenging, 2,2-diphenylpicrylhydrazyl, ferric reducing ability of plasma, and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate<sup>+</sup> were carried out. Moreover, phytochemical profiling and their quantification were also performed.</p></div><div><h3>Results</h3><p>The hydroalcoholic bark extract of <em>C. religiosa</em> has a strong anticancer prospective against PA-1 with a half-inhibitory concentration value of 33.27 μg/ml. The antioxidant potential of the extract showed potent activity on various antioxidants. The phytochemical profiling of the extract showed the presence of various phytochemicals and the quantification indicated the presence of a total phenol content of 2.1 ± 0.09 mg Gallic acid equivalent/g, total flavonoid content of 1.706 ± 0.01 mg CE/g, total alkaloid content of 1.237 ± 0.03 mg AE/g, and total terpenoid content of 1.004 ± 0.06 mg UAE/g.</p></div><div><h3>Conclusions</h3><p>The current findings of the study suggest the role of <em>C. religiosa</em> bark against human ovarian cancer cells (PA-1) and could be a potential drug source for the discovery of anticancer agents.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100870"},"PeriodicalIF":2.3,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.1016/j.hermed.2024.100874
Nursenem Karaca , Fatih Demirci
Introduction
The low water solubility, high volatility, and instability of essential oils limit the application of various formulations, which can be managed by essential oils nanoemulsions. In this present study, in vitro anti-inflammatory and anticholinesterase activities were evaluated by designing nanoemulsions of rosemary and coriander essential oils with their combinations.
Methods
The chemistry of Rosmarinus officinalis L. (Rosemary, Lamiaceae) and Coriandrum sativum L. (Coriander, Apiaceae) essential oils was confirmed by GC-FID and GC/MS methods. Oil-in-Water (O/W) emulsions of essential oils and their 1:1 (w:w) combination were prepared by water titration. The essential oil/tween 20 ratio of the emulsions were 1:9, 2:8, and 3:7 (w:w) respectively. Characterisation studies were performed by measuring the droplet size, polydispersity index (PDI), zeta potential, and viscosity of the emulsions. Also, resistance to centrifugation, freezing, and heating was determined as part of the stability tests. Anti-inflammatory effects of the essential oils and emulsions were determined by in vitro 5-Lipoxygenase (LOX) inhibition. In addition, in vitro Acetylcholinesterase and Butyrylcholinesterase (AChE and BuChE) effects were evaluated.
Results
The rosemary (1,8-cineole; 44.1%), coriander (linalool; 74.9%) essential oils, and their nanoemulsion formulations prepared were observed as stable. The anti-inflammatory activity of coriander essential oil was relatively increased by nanoemulsion preparations. However, there was no significant difference in the cholinesterase inhibition effects, when compared. To the best of our knowledge this is the first combination study of bioactivity evaluation of rosemary and coriander nanoemulsion preparations.
Conclusion
Rosemary and coriander essential oil nano emulsifications is a promising application for increasing stability and biological activity as well.
{"title":"In vitro cholinesterase, lipoxygenase inhibition evaluation of rosemary and coriander essential oil nanoemulsion and characterisation","authors":"Nursenem Karaca , Fatih Demirci","doi":"10.1016/j.hermed.2024.100874","DOIUrl":"10.1016/j.hermed.2024.100874","url":null,"abstract":"<div><h3>Introduction</h3><p>The low water solubility, high volatility, and instability of essential oils limit the application of various formulations, which can be managed by essential oils nanoemulsions. In this present study, <em>in vitro</em> anti-inflammatory and anticholinesterase activities were evaluated by designing nanoemulsions of rosemary and coriander essential oils with their combinations.</p></div><div><h3>Methods</h3><p>The chemistry of <em>Rosmarinus officinalis</em> L. (Rosemary, Lamiaceae) and <em>Coriandrum sativum</em> L. (Coriander, Apiaceae) essential oils was confirmed by GC-FID and GC/MS methods. Oil-in-Water (O/W) emulsions of essential oils and their 1:1 (w:w) combination were prepared by water titration. The essential oil/tween 20 ratio of the emulsions were 1:9, 2:8, and 3:7 (w:w) respectively. Characterisation studies were performed by measuring the droplet size, polydispersity index (PDI), zeta potential, and viscosity of the emulsions. Also, resistance to centrifugation, freezing, and heating was determined as part of the stability tests. Anti-inflammatory effects of the essential oils and emulsions were determined by <em>in vitro</em> 5-Lipoxygenase (LOX) inhibition. In addition, <em>in vitro</em> Acetylcholinesterase and Butyrylcholinesterase (AChE and BuChE) effects were evaluated.</p></div><div><h3>Results</h3><p>The rosemary (1,8-cineole; 44.1%), coriander (linalool; 74.9%) essential oils, and their nanoemulsion formulations prepared were observed as stable. The anti-inflammatory activity of coriander essential oil was relatively increased by nanoemulsion preparations. However, there was no significant difference in the cholinesterase inhibition effects, when compared. To the best of our knowledge this is the first combination study of bioactivity evaluation of rosemary and coriander nanoemulsion preparations.</p></div><div><h3>Conclusion</h3><p>Rosemary and coriander essential oil nano emulsifications is a promising application for increasing stability and biological activity as well.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100874"},"PeriodicalIF":2.3,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several studies have reported the ability of Bawang Dayak cream to inhibit Cutibacterium acnes, but the lack of specific formulations has led to its ineffectiveness. This is indicated by a smaller inhibition zone and the predominant scent of the plant. Therefore, this study aims to assess the physical characteristics and antibacterial activity of two modified formulations of Bawang Dayak anti-acne cream.
Methods
Two modified formulations of Bawang Dayak anti-acne cream were prepared, namely M1 (containing peppermint water) and M2 (comprising peppermint water, cinnamon extract, and honey). Each formulation had four concentrations: 5% (F1), 10% (F2), 15% (F3), and 20% (F4). The physical characteristics were then examined. The antibacterial activity test was carried out using the disc-diffusion method against acne-causing bacteria.
Results
The addition of peppermint water to the cream formula masked the odour of Bawang Dayak. All the formulas examined met the requirements of the homogeneity, pH, and spreadability tests. However, the adhesion test showed that only F2 and F4 of M2 met the requirement. The results also showed that M1 had better antibacterial activity compared to M2.
Conclusions
This study found that all the formulas observed passed the homogeneity, pH, and spreadability tests. Only F2 and F4 of M2 met the requirements of the adhesion tests. M1 exhibited superior antibacterial activity compared to the M2. F1 of M1 showed the highest antibacterial activity against Staphylococcus epidermidis. Further investigation was needed to evaluate the effectiveness of M2 against S. epidermidis and Staphylococcus aureus, as well as assess the stability.
{"title":"Formulation, physical characterization, and antibacterial activity of modifications of Bawang Dayak Eleutherine bulbosa (Mill.) Urb. anti-acne cream","authors":"Susi Novaryatiin, Rikha Nuramanah, Isnawati Isnawati, Selvia Susanti, Drenikha Sikhe Ryba Kanahuang, Syahrida Dian Ardhany","doi":"10.1016/j.hermed.2024.100869","DOIUrl":"10.1016/j.hermed.2024.100869","url":null,"abstract":"<div><h3>Introduction</h3><p>Several studies have reported the ability of Bawang Dayak cream to inhibit <em>Cutibacterium acnes</em>, but the lack of specific formulations has led to its ineffectiveness. This is indicated by a smaller inhibition zone and the predominant scent of the plant. Therefore, this study aims to assess the physical characteristics and antibacterial activity of two modified formulations of Bawang Dayak anti-acne cream.</p></div><div><h3>Methods</h3><p>Two modified formulations of Bawang Dayak anti-acne cream were prepared, namely M1 (containing peppermint water) and M2 (comprising peppermint water, cinnamon extract, and honey). Each formulation had four concentrations: 5% (F1), 10% (F2), 15% (F3), and 20% (F4). The physical characteristics were then examined. The antibacterial activity test was carried out using the disc-diffusion method against acne-causing bacteria.</p></div><div><h3>Results</h3><p>The addition of peppermint water to the cream formula masked the odour of Bawang Dayak. All the formulas examined met the requirements of the homogeneity, pH, and spreadability tests. However, the adhesion test showed that only F2 and F4 of M2 met the requirement. The results also showed that M1 had better antibacterial activity compared to M2.</p></div><div><h3>Conclusions</h3><p>This study found that all the formulas observed passed the homogeneity, pH, and spreadability tests. Only F2 and F4 of M2 met the requirements of the adhesion tests. M1 exhibited superior antibacterial activity compared to the M2. F1 of M1 showed the highest antibacterial activity against <em>Staphylococcus epidermidis.</em> Further investigation was needed to evaluate the effectiveness of M2 against <em>S. epidermidis</em> and <em>Staphylococcus aureus</em>, as well as assess the stability.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100869"},"PeriodicalIF":2.3,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140151378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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