Journal of Herbal Medicine最新文献

{"title":"General Physicians’ Attitude and Decision-Making Towards Herbal Medicines Prescription: A Scenario-Based Cross-Sectional Study in Hamadan, Iran","authors":"R. Abedi ,&nbsp;S. Moradkhani ,&nbsp;G. Afsharmanesh ,&nbsp;M. Rangchian","doi":"10.1016/j.hermed.2024.100844","DOIUrl":"10.1016/j.hermed.2024.100844","url":null,"abstract":"<div><h3>Introduction</h3><p>Although general physicians (<strong>GPs</strong>) considerably affect herbal medicines (<strong>HMs</strong>) consumption, there is not enough insight into their attitude and behaviour towards prescribing HMs. This study investigated the GPs’ attitudes towards HMs, the relationship between their attitude and the general preference for HMs, and the effect of the following variables on their prescription decisions for HMs: (1) GP’s experience regarding the effectiveness of that HM, (2) access to the side effects information, (3) patient's payment capacity, and (4) patient’s attitude towards HMs.</p></div><div><h3>Methods</h3><p>A survey was conducted in Hamadan, Iran. GPs’ demographics, attitude, and decision towards prescribing HMs were asked. Data analysis included descriptive statistics, Kruskal-Wallis, logistic regression, and correlation.</p></div><div><h3>Results</h3><p>SSixty GPs’ data were analyzed. Their attitude was not very positive; only 16.6% often or always preferred HMs. The likelihood of prescribing HMs was increased by positive experiences with effectiveness (OR=11.2, <em>p</em>-value=0.000, CI: 5.2-24.4) and access to side effects information (OR=6.9, <em>p</em>-value=0.000, CI: 3.5-13.9). Affordability problems reduced the chance of HM prescription for mild (OR=1.8, <em>p</em>-value=0.012, CI: 1.1–2.9) and severe problems (OR=6.9, <em>p</em>-value=0.000, CI: 3.6–13.3). Patient’s positive opinion about HMs increased the probability of HMs prescription compared to neutral (OR=2.6, <em>p</em>-value= 0.002, CI: 1.4 – 4.8) and negative opinion (OR=9.4, <em>p</em>-value=0.000, CI: 4.1–21.3). No significant influence was observed for GP’s sex, age and experience. The model correctly predicted 80.89% of stated decisionss.</p></div><div><h3>Conclusions</h3><p>Enhancement of GPs and patients’ trust in HMs’ effectiveness and safety and improve these products’ affordability is suggested to increase HMs’ prescription by GPs.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139409609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cycloisolongifolene-8,9-Dehydro-9-Formyl Inhibits Lipoxygenase and Might Play a Role in the Wound-Healing Property of Clerodendrum infortunatum and Tagetes erecta","authors":"Bhavana Sampath Kumar,&nbsp;Sandra Ravi M,&nbsp;Junaiha Kapoor,&nbsp;Atheene Joy,&nbsp;Elcey C. Daniel,&nbsp;Shinomol George K,&nbsp;Deepu Joy Parayil,&nbsp;Dileep Francis","doi":"10.1016/j.hermed.2023.100843","DOIUrl":"10.1016/j.hermed.2023.100843","url":null,"abstract":"<div><h3>Introduction</h3><p><span><em>Clerodendrum</em><em> infortunatum</em></span>, and <span><em>Tagetes erecta</em></span><span>, are frequently used in traditional medicinal systems like Ayurveda and Unani for their medicinal properties. This study explores their wound-healing potential.</span></p></div><div><h3>Methods</h3><p>Ethanol extracts were obtained from <em>C infortunatum</em> leaves and <em>T erecta</em><span> flowers and subjected to qualitative phytochemical<span> analyses. . The antioxidant properties were assessed through 2,2-diphenyl-picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) assays, both individually and combined. Cytotoxicity was tested using the MTT assay. An i</span></span><em>n vitro</em><span> lipoxygenase (</span><strong>LOX)</strong><span><span> inhibition assay was used to evaluate anti-inflammatory activity. Extracts were further fractionated using silica gel<span> column chromatography and assayed for LOX-inibition. Metabolite profiling of the active fractions were performed using GC-MS. </span></span>Molecular docking was employed to study the interactions of the identified metabolites with LOX.</span></p></div><div><h3>Results</h3><p>The plant extracts exhibited substantial scavenging activity (76–80% in the DPPH assay). FRAP values were 415.31 µg ascorbic acid/g DW for <em>C infortunatum</em> and 1185.86 µg ascorbic acid/g DW for <em>T erecta</em>. The extracts and fractions showed moderate cytotoxicity, with the highest non-toxic concentration being 25 µg/mL. LOX inhibition was 54% for <em>C infortunatum</em>, and 56% for <em>T erecta</em><span>, comparable to vanillin (55%). Purified fractions achieved 70% (</span><em>C infortunatum</em>) and 76% (<em>T erecta</em>) inhibition. Proliferation assays revealed significant wound-healing activities of 76% (<em>C infortunatum)</em> and 90% (<em>T erecta</em>) at 25 µg/mL, compared to the control (50%). GC-MS identified the key metabolite, cycloisolongifolene-8,9-dehydro-9-formyl, in both fractions. Molecular docking provided mechanistic insights into LOX inhibition.</p></div><div><h3>Conclusions</h3><p><em>C infortunatum</em> (leaf) and <em>T erecta</em> (flower) extracts possess remarkable wound-healing potential. The identified metabolite, cycloisolongifolene-8,9-dehydro-9-formyl, likely contributes to wound healing. The findings highlight the therapeutic potential of the plant extracts in wound management and warrant further investigation into the active principle/s involved in the mechanism.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139094305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective, Controlled, Pilot Study of Personalised Add-on Ayurveda Treatment in High-Risk Type II Diabetes COVID-19 Patients","authors":"Somit Kumar ,&nbsp;Sujith Subash Eranezhath ,&nbsp;Vinod Kumar Vishwanathan ,&nbsp;Mitravinda Sai Kakarla ,&nbsp;Chaithanya Chenthamarakshan ,&nbsp;Lakshmiprabha Selvaraj ,&nbsp;Balagopal Satheeshan ,&nbsp;Indulal Unniappan ,&nbsp;Balaji Purushotham ,&nbsp;Valdis Pīrāgs ,&nbsp;Daniel Furst","doi":"10.1016/j.hermed.2023.100836","DOIUrl":"10.1016/j.hermed.2023.100836","url":null,"abstract":"<div><h3>Introduction</h3><p>In hospitalised mild to moderate COVID-19 patients with pre-existing type 2 diabetes, we evaluated the efficacy of add-on customised Ayurveda intervention as compared to standard of care (<strong>SOC</strong>) in ameliorating symptoms, avoiding the need for ICU admission and ventilator support plus bringing down interleukin-6 (<strong>IL-6</strong>), and C-reactive protein (<strong>CRP</strong>) over 15 days.</p></div><div><h3>Methods</h3><p>In this quasi-experimental trial, 24 participants per arm diagnosed with COVID-19 by RT-PCR, aged 18–75 years, fulfilling the inclusion/exclusion criteria, were inducted. The subjects were allocated, depending on their own voluntary choice, to SOC plus Ayurveda (group 1) or SOC alone (group 2) for 15 days. The analyses used the Cochran-Mantel-Haenszel test, multivariate ANOVA plus within-group repeated measures ANOVA, and Cochran’s Q test.</p></div><div><h3>Results</h3><p>Of the 13 symptoms, cough (<em>P</em> = 0.04), general weakness (<em>P</em> = 0.02), and sore throat (<em>P</em> = 0.02) were statistically significantly different across the groups, with group I (add-on) improving better than group II (SOC). IL-6 dropped rapidly in group 1 by 7 days (<em>P</em> = 0.006) group 2 caught up by day 15 (<em>P</em> = 0.001). CRP improved slower than IL-6. The time to maximum change was not statistically different for IL-6 and CRP between the groups at day 15. There were no differences in random blood sugar and adverse events to Ayurveda-added SOC group.</p></div><div><h3>Conclusions</h3><p>In this quasi-experimental cough, weakness, and sore throat improved more in the add-on Ayurveda than in the SOC. IL-6 concentrations are declining more rapidly in the add-on Ayurveda. Clinical and laboratory adverse events suggested no additional toxicity of add-on Ayurveda treatments. This study supports the need for a randomised, double-blind trial.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2210803323002142/pdfft?md5=bb8795c8ac75b936f49e979c16531263&pid=1-s2.0-S2210803323002142-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leishmanicidal Activity of Moringa oleifera (L.) Leaf Protein Extract on the Indian Strain of Leishmania donovani: An In Vitro Study","authors":"P. Devgupta,&nbsp;P.K. Pramanik,&nbsp;D Roy Chowdhury,&nbsp;P. Ghosh,&nbsp;T. Chakraborti","doi":"10.1016/j.hermed.2023.100832","DOIUrl":"10.1016/j.hermed.2023.100832","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Recurring incidents of drug resistance and the health hazards associated with the chemotherapeutic treatment<span> of visceral leishmaniasis necessitate the search for safer yet equally effective biologically available alternate therapeutics. Plant products are being emphasised in this regard. Thus, </span></span><span><em>Moringa oleifera</em></span> leaf was chosen here, and an <em>in vitro</em> study was undertaken to determine its antileishmanial activity against visceral leishmaniasis.</p></div><div><h3>Methods</h3><p>The protein in <em>M. oleifera</em> leaf extract (<strong>Mo-EX</strong><span><span>) was identified by denaturing polyacrylamide gel electrophoresis. The antipromastigote activity and cytotoxicity of the proteinaceous Mo-EX were determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Phase contrast microscopy<span> and scanning electron microscopy analyses confirmed the morphological alterations of the </span></span>promastigotes<span>. The anti-amastigote activity of Mo-EX was determined by microscopic intracellular counting. Apoptosis<span>, reactive oxygen species (</span></span></span><strong>ROS</strong><span><span>) generation, and thiol depletion were assessed by flow cytometric analysis, and nitric oxide production was determined by </span>colorimetric assays.</span></p></div><div><h3>Results</h3><p><em>M. oleifera</em> leaf extract displayed 50% inhibitory concentration valuesagainst <span><em>Leishmania donovani</em></span> promastigotes and intracellular amastigotes of 11.85 ± 0.08 and 8.86 ± 0.03 μg/ml, respectively, with a 50% lethal concentration in RAW 264.7 macrophages of 2 036.25 ± 0.04 μg/ml. Mo-EX reduced thiol production, significantly increased ROS generation, and induced apoptosis in <em>L. donovani</em> promastigotes while altering their morphology. Mo-EX evoked ROS and nitric oxide generation in parasite-infected host cells <span><em>ex vivo</em></span>.</p></div><div><h3>Conclusions</h3><p>The findings of the present study elucidate the leishmanicidal activity of protein-rich Mo-EX in <em>L. donovani</em> (MHOM/IN/1983/AG83) promastigotes and amastigotes, and Mo-EX was found to be moderately safe in RAW 264.7 host macrophages <em>in vitro.</em></p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the efficacy of Achyranthes aspera gel with tetracycline fibres in managing periodontitis: a single-blind, randomised clinical study","authors":"Tania D’cruz ,&nbsp;Vandana Panda ,&nbsp;Mala Dixit ,&nbsp;Geetika Prabhakar ,&nbsp;Nikita Patil","doi":"10.1016/j.hermed.2023.100842","DOIUrl":"10.1016/j.hermed.2023.100842","url":null,"abstract":"<div><h3>Introduction</h3><p>The present study formulates, evaluates, and compares a gel made from <span><em>Achyranthes aspera</em></span><span><span> root extract (AAE) with tetracycline fibers for its protective effect </span>in patients<span> suffering from chronic periodontitis.</span></span></p></div><div><h3>Methods</h3><p>The AAE gel was evaluated for various physicochemical parameters, <em>in vitro</em><span><span> permeability, and stability, and the active phytoconstituent rutin<span> was quantified in AAE by high performance thin layer chromatography (HPTLC). Patients (20-60 years) suffering from chronic </span></span>periodontitis<span> with a probing pocket depth (PPD) of 5-7 mm and no systemic diseases<span><span> were divided into 2 groups (20 each) and treated with scaling and root planing (SRP) followed by subgingival placement of the herbal gel or tetracycline fibers (standard). </span>Plaque Index<span> (PI), Gingival Index (GI), Pocket Probing Depth (PPD), and Clinical Attachment Level (CAL) were recorded at baseline and after 3 months. The student’s t-test was used for statistical analysis.</span></span></span></span></p></div><div><h3>Results</h3><p><span>The AAE gel was found to be stable for 2 months, and the content of rutin was found to be 0.76µg in 100mg of AAE. A significant reduction in the periodontal disease parameters was observed in the standard and gel-treated groups between their baseline and 3-month interval values. The herbal gel </span>treatment was comparable to tetracycline treatment in significantly attenuating the periodontitis-elevated PI, GI PPD, and CAL levels.</p></div><div><h3>Conclusion</h3><p>The amelioration of periodontitis and gingival inflammation by the AAE gel may be attributed to the potent antioxidant and anti-inflammatory activity of its phytoconstituents. AAE gel may thus be used as a safe adjunct to SRP in chronic periodontitis. CTRI/2018/09/015621 [Registered on: 06/09/2018]</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138820970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical research hotspots and trends of atherosclerosis treatment with traditional Chinese medicine preparations","authors":"Jingyi Li,&nbsp;Jiao Wu,&nbsp;Xiaohu Xue,&nbsp;Jianhe Fang,&nbsp;Jingjing Li,&nbsp;Meiying Ao","doi":"10.1016/j.hermed.2023.100839","DOIUrl":"10.1016/j.hermed.2023.100839","url":null,"abstract":"<div><h3>Introduction</h3><p><span>While traditional Chinese medicine (TCM) has proved to be effective in treating </span>atherosclerosis<span> (AS), further analyses of the current research trends and treatment quality are essential. Based on data and visualisation analyses, this study aimed to explore the research hotspots and trends of AS treatment with TCM.</span></p></div><div><h3>Methods</h3><p>Relevant literature was searched using the evidence-based strategy system. Visual cluster analysis, association rule analysis, and study quality evaluation were performed using VOSviewer, IBM SPSS Statistics 23, Cochrane Risk Bias Assessment Scale, and Modified Jadad Scale.</p></div><div><h3>Results</h3><p>A total of 334 eligible papers were included. Over the past decade, the number of annual publications in this field has substantially increased, with a shift towards combining Chinese and Western medicine and using standardised and detailed outcome indicators. The frequently used herbs have warm or cold nature, sweet or bitter flavour, and belong to the liver, lung, or spleen channel. <span><em>Salvia miltiorrhiza</em></span> Bunge (Danshen) - <span><em>Astragalus</em><em> mongholicus</em></span> Bunge (Huangqi) + <em>Conioselinum anthriscoides</em> 'Chuanxiong' (Chuanxiong) was the most commonly used combination, while <span><em>Carthamus tinctorius</em></span> L. (Honghua) - <em>Prunus persica</em> (L.) Batsch (Taoren) + Chuanxiong was associated with the highest confidence. The protocols of studies with a high risk of bias lacked standardisation, and the administration protocols of different clinical studies that used the same TCM preparations showed significant diversification. Despite this, the literature quality has shown pronounced growth in recent years.</p></div><div><h3>Conclusions</h3><p>Clinical research on AS prevention and treatment using TCM preparations is popular and follows TCM pathology theory; however, the overall research quality needs further improvement.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138993938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Lantana camara Ethanolic Leaf Extract on Survival and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cell Line","authors":"A. Pal ,&nbsp;S. Sanyal ,&nbsp;S. Das,&nbsp;T.K. Sengupta","doi":"10.1016/j.hermed.2023.100837","DOIUrl":"10.1016/j.hermed.2023.100837","url":null,"abstract":"<div><h3>Introduction</h3><p>Breast cancer is a leading cause of cancer-related death worldwide. <span><em>Lantana camara</em></span><span><span> has been reported to cure a number of ailments, with few studies showing its cytotoxic effects on breast </span>cancer cells. However, the impact of </span><em>L. camara</em> on triple-negative breast cancer cells is largely obscure to date. The present study investigated the effect of ethanolic extract of <em>L. camara</em> leaves on the triple-negative breast cancer cell line, MDA-MB-231.</p></div><div><h3>Methods</h3><p><span>Cytotoxic effect of the extract on the cells was determined by cell survival assay. Cell-cycle phase distribution was analysed using flow cytometry. To study the effect on nuclear morphology, nuclear-stained cells were visualised using epifluorescence microscopy. The induction of </span>apoptosis<span> and generation of reactive oxygen species<span> were conducted using flow cytometry. Cellular migration was studied by performing wound healing assay. Real-time polymerase chain reaction was done to determine the mRNA levels of some key genes.</span></span></p></div><div><h3>Results</h3><p><em>L. camara</em> leaf extract induced cytomorphological changes and growth-inhibitory effect on MDA-MB-231 cells in a dose-dependent manner. The extract also induced G0/G1 cell-cycle arrest and nuclear condensation. Flow cytometry analysis confirmed cell death by apoptosis. <em>L. camara</em><span> leaf extract also reduced the migration of MDA-MB-231 cells. mRNA expression levels also supported the above observations.</span></p></div><div><h3>Conclusions</h3><p>This study demonstrates the efficacy of the extract to induce growth-inhibitory and antimigratory effects on MDA-MB-231 cells. Our results thus suggest that <em>L. camara</em> leaf extract can be considered as a potent source of chemotherapeutic agents for triple-negative breast cancer.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Scrophularia striata hydroalcoholic extract on differentiation of human adipose-derived mesenchymal stem cells into chondrocytes and osteocytes","authors":"Zahra Bagheri-Hosseinabadi ,&nbsp;Fatemeh Javani Jouni ,&nbsp;Jaber Zafari ,&nbsp;Saba Sadeghi ,&nbsp;Mitra Abbasifard","doi":"10.1016/j.hermed.2023.100841","DOIUrl":"10.1016/j.hermed.2023.100841","url":null,"abstract":"<div><h3>Introduction</h3><p><span><span>Osteoarthritis is a major type of </span>joint disease. Cell therapy is the main hopeful therapeutic method to treat this disorder. The aim of this study was to determine the effect of </span><span><em>Scrophularia</em><em> striata</em></span><span> hydroalcoholic extract on the differentiation of human adipose tissue-derived stem cells to chondrogenic and osteogenic cells a perspective for treatment of Osteoarthritis.</span></p></div><div><h3>Methods</h3><p>The hydroalcoholic extract of <em>S. striata</em> were prepared. The <em>S. striata</em><span><span> extract was standardised according to gallic acid<span> and querctin by HPLC<span><span>. Human adipose-derived mesenchymal stem cells (hADSCs) were cultured in DMEM/F12 complemented with 10% fetal bovine serum. After the identification of cells, </span>cell viability was measured by </span></span></span>MTT assays, 24 and 48 hours after treatment with different concentrations of plant extract. The expression pattern of special chondrogenic and osteogenic genes and stem cell markers was evaluated through real time-PCR.</span></p></div><div><h3>Results</h3><p>Our findings showed that the <em>S. striata</em> plant extract has the capability of reducing the viability of hADSCs cells at concentration of 800 and 1000 ug/ml after 24 and 48 hours. The dosage of <em>S. striata</em> that significantly induced hADSCs cell differentiation is IC25, and the IC50 for hADSCs was 865.0 and 642.9 µg/ml after 24 and 48 hours, respectively. The hydroalcoholic extract of the <em>S. striata</em><span> was standardised according to Gallic acid (0.33 mg gallic acid/g Extract) and Quercetin (2.81 mg quercetin/g Extract) compounds.</span></p></div><div><h3>Conclusion</h3><p>The results showed that in addition to exerting anti-inflammatory effects, <em>S. striata</em> can induce the orientation of hADSCs cells into osteogenic and chondrogenic cells.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138820966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of antidiabetic and antioxidant properties of fresh and freeze-dried Hellenia speciosa, Coccinia grandis and Gymnema sylvestre leaves","authors":"Maheshika Peries ,&nbsp;Seneveratne Navartne ,&nbsp;Kanchana Abeysekara ,&nbsp;Ranil Coorey ,&nbsp;Amila Henagamage ,&nbsp;Janaka Wijesinghe","doi":"10.1016/j.hermed.2023.100838","DOIUrl":"10.1016/j.hermed.2023.100838","url":null,"abstract":"<div><h3>Introduction</h3><p>The drying method can have an impact on the stability and composition of bioactive compounds in plant materials, as well as their therapeutic activities. This study aimed at evaluating the anti-glycation and antioxidant properties of freeze-dried and fresh leaves of selected ayurvedic medicinal plants.</p></div><div><h3>Methods</h3><p>Fresh and freeze-dried leaves of <span><em>Hellenia speciosa, </em><em>Gymnema sylvestre</em></span> and <span><em>Coccinia grandis</em></span><span> were extracted separately with 95% ethanol. The extracts were studied for their anti-glucosidase, antiglycation, glycation-reversing activities and uptake of glucose by yeast cells<span><span><span>. Antioxidant activities of extracts were evaluated using </span>ABTS and </span>DPPH<span> free radical scavenging activities.</span></span></span></p></div><div><h3>Results</h3><p>All extracts of the freeze-dried leaves showed significant (<em>P</em> &lt; 0.05) anti-glucosidase, antiglycation, and glycation-reversing activities than the fresh leaves of the same species. The freeze-dried leaf extract of <em>H. speciosa</em><span> demonstrated the highest antiglycation, anti-glucosidase, and glycation reversing activities among the plant species, with IC50 values of 100.76 ± 5.99 µg/ml, 28.11 ± 1.30 µg/ml and EC50 values of 147.24 ± 3.86 µg/ml, respectively. In addition to that, freeze-dried </span><em>H. speciosa</em> showed the maximum ABTS and DPPH free radical scavenging activity.</p></div><div><h3>Conclusions</h3><p>This study confirmed that freeze-dried leaves have promising anti-diabetic and antioxidant properties that can be used to develop herbal nutritional supplements<span><span> or functional foods for diabetes mellitus </span>treatment.</span></p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138821413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monograph on the Use of Herbs to Address Metabolic Syndrome","authors":"R. Lyons","doi":"10.1016/j.hermed.2023.100840","DOIUrl":"10.1016/j.hermed.2023.100840","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Metabolic syndrome is a collection of symptoms that have become an issue on a global scale. While </span>allopathic medicine can address the downstream symptoms, the metabolic pathways that are the root cause of the syndrome can be managed using herbs.</p></div><div><h3>Methods</h3><p>Criteria for the syndrome were set by the World Health Organization. Suggested herbs are taken from World Health Organization monographs, the British Pharmacopoeia, the United States Pharmacopoeia and the National Formulary, the Ayurvedic Pharmacopoeia, the Pharmacopoeia of the People's Republic of China, and the Japanese Pharmacopoeia. Herbs are cross-referenced with the primary literature when possible. Dietary recommendations and supplements are mentioned tangentially; however, they are not the intended focus of this monograph.</p></div><div><h3>Results</h3><p><span>Hyperglycemia is considered a principal component and driver of metabolic syndrome. Insulin resistance, glycolysis, and insulin production can all be affected by herbs. </span>Lipid metabolism occurs primarily in the liver; liver function can be enhanced using herbs. Inflammation caused by a hyperglycemic state can also be managed using herbs and reduced the progression of associated diseases. Since glycolysis and energy production occur in the mitochondria, supporting mitochondrial health with herbs is critical to positively affecting metabolic syndrome.</p></div><div><h3>Conclusions</h3><p>By using herbs to manage hyperglycemia, inflammation, liver congestion, and mitochondrial health, metabolic syndrome can be slowed, stopped, or even reversed.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}