Journal of Herbal Medicine最新文献_第7页

Unravelling the Anti-inflammatory Potential of Mitragyna parvifolia: A Mechanistic and Data-Driven Approach to Herbal Medicine 揭示小叶密天竺的抗炎潜力：一种机制和数据驱动的草药方法

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-07-03 DOI: 10.1016/j.hermed.2025.101038

Sukanya Pote , Preeti Salve , Sachin Gudasi , Shailendra Gurav

Introduction

Inflammation is a protective physiological response, but its chronic manifestation leads to adverse health outcomes. Current anti-inflammatory treatments often have significant side effects, necessitating safer alternatives. Mitragyna parvifolia, a medicinal plant, has demonstrated anti-inflammatory potential, though its mechanisms remain underexplored. The current study was designed to explore the anti-inflammatory mechanisms of M parvifolia, emphasising its potential as therapeutic agent for inflammatory diseases.

Methods

This study employed in silico approaches, including network pharmacology, molecular docking, and molecular dynamic simulations, to identify interactions between M parvifolia phytocompounds and inflammatory targets. Experimental validation was conducted using supercritical CO₂ leaf extract, evaluated for cytotoxicity, protein denaturation, COX-2 inhibition, and HRBC membrane stabilisation and phytochemical profiling using LC-QTOF-MS analysis.

Results

Thirteen phytocompounds of M parvifolia were found to modulate 97 inflammatory targets, significantly impacting Interleukin-17 and TNF signalling pathways. Molecular docking revealed strong binding of compounds to key targets, including MMP9 and PTGS2, with the MMP9-Corynan-17-ol complex showing the highest stability in simulations. LC-QTOF-MS analysis identified 10 major bioactive constituents, supporting in silico predictions. Experimental assays confirmed low cytotoxicity (>90% cell viability) and demonstrated potent anti-inflammatory effects: 73.71% ± 1.5% inhibition of COX-2 activity, 73.9% ± 0.4% inhibition of protein denaturation, and 75.5% ± 0.83% HRBC membrane stabilisation at maximum concentrations.

Conclusions

M parvifolia exhibits significant anti-inflammatory properties through modulation of key pathways and targets, combined with strong experimental validation of its efficacy and safety. These findings position M parvifolia as a promising candidate for developing natural, safer anti-inflammatory therapies.

炎症是一种保护性生理反应，但其慢性表现会导致不良的健康结果。目前的抗炎治疗通常有明显的副作用，需要更安全的替代品。药用植物米特拉古纳（Mitragyna parvifolia）已显示出抗炎潜力，但其机制仍未得到充分探索。本研究旨在探讨小叶草的抗炎机制，强调其作为炎症性疾病治疗剂的潜力。方法采用网络药理学、分子对接、分子动力学模拟等方法，研究细叶草化合物与炎症靶点的相互作用。实验验证使用超临界CO2叶提取物，评估细胞毒性，蛋白质变性，COX-2抑制和HRBC膜稳定性，并使用LC-QTOF-MS分析植物化学谱。结果发现13种植物化合物可调节97个炎症靶点，显著影响白细胞介素-17和TNF信号通路。分子对接揭示了化合物与关键靶点的强结合，包括MMP9和PTGS2，其中MMP9- coryan -17-ol复合物在模拟中表现出最高的稳定性。LC-QTOF-MS分析鉴定出10种主要生物活性成分，支持计算机预测。实验分析证实了低细胞毒性（>；90%细胞活力）和有效的抗炎作用：在最大浓度下，COX-2活性抑制73.71% ± 1.5%，蛋白变性抑制73.9% ± 0.4%，HRBC膜稳定75.5% ± 0.83%。结论小檗通过调节关键通路和靶点具有明显的抗炎作用，其有效性和安全性得到了有力的实验验证。这些发现使细小分枝杆菌成为开发天然、更安全的抗炎疗法的有希望的候选者。

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引用次数: 0

Green Synthesis of Silver Nanoparticles Using Mangifera indica Leaves and Their Antibacterial Efficacy Against Multidrug-Resistant Bacteria 芒果叶绿色合成纳米银及其对多重耐药菌的抗菌作用

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-07-03 DOI: 10.1016/j.hermed.2025.101039

Mohammed Alissa

The rise of multidrug-resistant bacteria presents a critical challenge to healthcare, prompting the need for alternative antimicrobial strategies. This study explores the potential of Mangifera indica (mango leaves) combined with silver nanoparticles (AgNPs) as a solution due to their bioactive properties. Phytochemical screening confirmed the presence of key bioactive compounds, including terpenoids, steroids, phenols, flavonoids, tannins, and biomolecules such as magniferin and benzoquinone di-tert-butyl derivative. Silver nanoparticles were synthesised using both aqueous and ethanolic extracts, with the antibacterial efficacy tested against methicillin-resistant Escherichia coli, oxacillin-resistant Klebsiella spp, methicillin-resistant Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus. The ethanolic extract demonstrated superior antibacterial activity, with inhibition zones of 19.7 mm against E coli, 26.8 mm against Klebsiella spp, 22.9 mm against P aeruginosa, and 24.1 mm against S aureus at 100 mg/ml. The ethanolic extract also exhibited lower minimum inhibitory concentration and minimum bactericidal concentration values, indicating greater potency compared to the aqueous extract. These results align with previous research, where plant-derived AgNPs, particularly from ethanolic extracts, have shown stronger antimicrobial activity due to better solubility of bioactive compounds. Overall, M indica extracts synthesised with AgNPs, especially using ethanol, offer significant potential in combating multidrug-resistant bacteria and provide an eco-friendly alternative to traditional antibiotics. Further research into clinical applications is recommended.

耐多药细菌的增加对卫生保健提出了严峻的挑战，促使需要替代抗微生物策略。由于其生物活性特性，本研究探索了芒果叶与银纳米粒子（AgNPs）结合作为一种解决方案的潜力。植物化学筛选证实了关键生物活性化合物的存在，包括萜类、类固醇、酚类、黄酮类、单宁和生物分子，如magnifin和苯醌二叔丁基衍生物。利用水萃取物和乙醇萃取物合成了纳米银，并对耐甲氧西林的大肠杆菌、耐氧西林的克雷伯氏菌、耐甲氧西林的铜绿假单胞菌和耐甲氧西林的金黄色葡萄球菌进行了抗菌效果测试。乙醇提取物表现出优异的抑菌活性，对大肠杆菌的抑菌带为19.7 mm，对克雷伯氏菌的抑菌带为26.8 mm，对铜绿假单胞菌的抑菌带为22.9 mm，对金黄色葡萄球菌的抑菌带为24.1 mm，浓度为100 mg/ml。乙醇提取物也表现出较低的最低抑菌浓度和最低杀菌浓度值，表明与水提取物相比，乙醇提取物的效力更强。这些结果与先前的研究相一致，其中植物衍生的AgNPs，特别是来自乙醇提取物的AgNPs，由于生物活性化合物的溶解度更好而显示出更强的抗菌活性。总的来说，用AgNPs合成的籼稻提取物，特别是用乙醇合成的籼稻提取物，在对抗多药耐药细菌方面具有巨大的潜力，并为传统抗生素提供了一种环保的替代品。建议进一步研究其临床应用。

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引用次数: 0

Guava (Psidium guajava) leverages platelets in dengue haemorrhagic fever in Indonesia: Bayesian and Frequentist ANCOVA recovered meta-analyses 番石榴（Psidium guajava）在印度尼西亚登革热出血热中利用血小板：Bayesian和Frequentist ANCOVA恢复荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-07-02 DOI: 10.1016/j.hermed.2025.101037

Jonathan, Theodorus Samuel Rahardja, Dede Fatmawati, Maudy Rahmi, Indah Ridhoila

Background

Tropical countries with humid climates and large populations, such as Indonesia, have a high prevalence of dengue haemorrhagic fever (DHF). The symptoms can range from mild fever to shock or even death. Spontaneous bleeding due to thrombocytopenia is one such example. Therefore, restoring thrombocyte levels is a key factor in DHF recovery. Contradictory evidence exists regarding the effects of guava (Psidium guajava) on thrombocytes in patients with DHF. In this study, we resolved this debate using Frequentist and Bayesian meta-analyses.

Methods

A comprehensive systematic review and meta-analysis of 972 articles from six databases, one registry, and a citation search from conception to 2024 identified seven studies after rigorous inclusion-exclusion filtration. All studies passed the quality assessment using the Risk of Bias 2 tool, Newcastle Ottawa Scale, and the risk of bias in non-randomised studies of interventions. Statistical analysis was performed using R version 4.4.2, analysis of covariance recovered effect size, Bayesmeta, and Metafor packages. Additionally, the authors used a DOI plot and the Luis Furuya-Kanamori index to assess publication bias.

Results

The current meta-analysis included seven studies with 234 subjects for the pre- and post-difference in platelet count with a control group contrast. Guava adequately increased the platelet count in DHF patients (63.21 [57.20–69.26] x 10³) in both adult and paediatric patients.

Conclusion

We summarise the role of guava in enhancing platelet counts in Indonesia. Guava fruit should be considered a complementary treatment alongside standard medicine for treating adult Indonesian patients with DHF in healthcare facilities and homes.

气候潮湿、人口众多的热带国家，如印度尼西亚，登革热出血热（DHF）的流行率很高。症状从轻度发烧到休克甚至死亡。血小板减少症引起的自发性出血就是这样一个例子。因此，恢复血小板水平是DHF恢复的关键因素。关于番石榴（Psidium guajava）对DHF患者血小板的影响，存在相互矛盾的证据。在本研究中，我们使用频率分析和贝叶斯元分析解决了这一争论。方法对来自6个数据库、1个注册库和引文检索的972篇文章进行综合系统评价和meta分析，经过严格的纳入排除过滤，筛选出7篇研究。所有研究均通过了使用偏倚风险2工具、纽卡斯尔渥太华量表和干预措施的非随机研究的偏倚风险的质量评估。采用R 4.4.2进行统计分析，协方差分析恢复效应大小，Bayesmeta和Metafor软件包。此外，作者使用DOI图和Luis Furuya-Kanamori指数来评估发表偏倚。目前的荟萃分析包括7项研究，共234名受试者，与对照组相比，血小板计数前后的差异。番石榴可充分提高成人和儿童DHF患者的血小板计数（63.21 [57.20-69.26]× 103）。结论总结了番石榴在印度尼西亚提高血小板计数的作用。番石榴应被视为在卫生保健机构和家庭中治疗印度尼西亚成年登革出血热患者的补充药物。

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引用次数: 0

Essential oil of Cleome coluteoides (Boiss.): phytochemical constituents, antioxidant, antimicrobial, antiproliferative, anti-inflammatory, enzymatic inhibition, and xanthine oxidase inhibitory properties 丁香精油（Boiss.）：植物化学成分，抗氧化，抗菌，抗增殖，抗炎，酶抑制和黄嘌呤氧化酶抑制特性

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-09 DOI: 10.1016/j.hermed.2025.101036

Majid Sharifi-Rad , Jibanjyoti Panda , Yugal Kishore Mohanta , Pawel Pohl , Gokhan Zengin , Mark G. Moloney

Introduction

Plant based natural products are well known for their therapeutic potential as they are used to treat many diseases, but these plants need to be validated through the scientific study. Therefore, the present investigation was carried out to evaluate the usefulness of the bioactive compounds present in the essential oils of the Cleome coluteoides.

Methods

Different parts of the plant, including leaves, flowers, fruits, stems and roots, were used to extract the essential oils. The chemical composition of essential oils was analysed by gas-chromatography mass spectrometry (GC-MS). Their antimicrobial properties were evaluated against several human pathogens (three fungi and four bacteria). The enzyme inhibition activity (α-amylase, tyrosinase, butyrylcholinesterase, acetylcholinesterase inhibitory tests) of the essential oils was evaluated, along with, their antioxidant activity (DPPH, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) tests), xanthine oxidase inhibitory activity, antiproliferative activity (against MCF-7 and Hep-G2), anti-arthritic activity (protein denature assay), and anti-inflammatory activity.

Results

Phytol, sclareol, 7-α-hydroxy manool, and piperitone were found to be the main compounds of the studied essential oils. Notable antibacterial, antifungal, enzyme inhibition, antioxidant, xanthine oxidase inhibitory, antiproliferative, anti-arthritic, and inflammatory activities were found form the essential oils. The best activity was found in the case of the essential oils made from leaves.

Discussion/Conclusions

These potential biological activities along with the chemical constitutes present in the essential oils of C. coluteoides can make them potentially utilisable in different biomedical and therapeutic applications in the future. Additionally, the studied plant and their essential oils can serve as a natural remedy for a variety of lifestyle diseases.

基于植物的天然产物以其治疗潜力而闻名，因为它们被用于治疗许多疾病，但这些植物需要通过科学研究来验证。因此，本研究是为了评价其精油中存在的生物活性化合物的有效性。方法采用叶、花、果、茎、根等不同部位提取挥发油。采用气相色谱-质谱法（GC-MS）分析了精油的化学成分。它们对几种人类病原体（三种真菌和四种细菌）的抗菌性能进行了评估。评估了精油的酶抑制活性（α-淀粉酶、酪氨酸酶、丁基胆碱酯酶、乙酰胆碱酯酶抑制试验），以及抗氧化活性（DPPH、2,2'-氮化-二（3-乙基苯并噻唑啉-6-磺酸）试验）、黄嘌呤氧化酶抑制活性、抗增殖活性（抗MCF-7和Hep-G2）、抗关节炎活性（蛋白质变性试验）和抗炎活性。结果所研究精油的主要成分为叶醇、香核醇、7-α-羟基醇和胡椒酮。该精油具有显著的抗菌、抗真菌、酶抑制、抗氧化、黄嘌呤氧化酶抑制、抗增殖、抗关节炎和炎症活性。从树叶中提取的精油的活性最高。讨论/结论这些潜在的生物活性及其所含的化学成分使其在未来的生物医学和治疗领域具有潜在的应用价值。此外，所研究的植物及其精油可以作为各种生活方式疾病的自然疗法。

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引用次数: 0

Targeting NAFLD and NASH with Tinospora crispa: insights from network pharmacology and molecular dynamics 用crispa Tinospora靶向NAFLD和NASH：来自网络药理学和分子动力学的见解

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-06 DOI: 10.1016/j.hermed.2025.101035

Shuvam Sar , Nurul Hassan Mondal , Tanmoy Banerjee , Amit Kumar Halder , Nilanjan Ghosh

Introduction

Tinospora crispa (TC), also known as ‘Petawali,’ is an Indian medicinal plant renowned in folk medicine and Ayurveda for its extensive therapeutic properties. Despite its known benefits, the hepatoprotective potential of TC, particularly against Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), remains unexplored scientifically. This study aims to identify phytocompounds in TC that may be effective against NAFLD/NASH-related targets and elucidate their mechanisms of action.

Method

We utilised fingerprint-based similarity search analyses to predict targets for each phytocompound. Network pharmacology, facilitated by ‘Cytoscape’ and its ‘Cytohubba’ plugins, was employed to establish connections between specific phytocompounds of TC and potential targets of NAFLD. Molecular docking followed by MM/GB(PB)SA scoring analyses were performed with these phytochemicals against a range of crystal structures and homology models of biological target proteins. Around 500 ns molecular dynamics simulations were conducted for the selected biological targets and docked phytoconstituents to understand dynamic behaviours of the complexes.

Result

Molecular docking and MM/GB(PB)SA scoring revealed that 3′-O-methylluteolin, diosmetin, genkwanin, and luteolin may show promising activity whereas molecular dynamics simulation highlighted that 3′-O-methylluteolin might be the most suitable phytochemical for NAFLD treatment.

Conclusion

Overall, these four compounds may modulate key proteins such as CYP3A4, MMP1, PPARδ, PPARγ, AKT1, CYP1A2, and STAT3. This study provides a scientific basis for the potential use of TC in managing NAFLD and NASH, encouraging further research and development in this domain.

tinospora crispa (TC)，也被称为“Petawali”，是一种印度药用植物，因其广泛的治疗特性而在民间医学和阿育吠陀中享有盛誉。尽管有已知的益处，但TC的肝保护潜力，特别是对非酒精性脂肪性肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）的保护潜力仍未得到科学探索。本研究旨在鉴定TC中可能对NAFLD/ nash相关靶点有效的植物化合物，并阐明其作用机制。方法采用基于指纹图谱的相似度搜索分析方法预测各植物化合物的靶点。网络药理学，通过‘ Cytoscape ’及其‘ Cytohubba ’插件，建立了TC特定植物化合物与NAFLD潜在靶点之间的联系。对这些植物化学物质进行分子对接，然后进行MM/GB(PB)SA评分分析，与一系列生物靶蛋白的晶体结构和同源性模型进行比较。对选定的生物靶点和对接的植物成分进行了约500 ns的分子动力学模拟，以了解配合物的动力学行为。结果分子对接和MM/GB(PB)SA评分显示，3′- o -甲基木犀草素、洋芋素、根宽素和木犀草素可能具有良好的活性，而分子动力学模拟显示，3′- o -甲基木犀草素可能是治疗NAFLD最合适的植物化学物质。综上所述，这4种化合物可能调控CYP3A4、MMP1、PPARδ、PPARγ、AKT1、CYP1A2和STAT3等关键蛋白。本研究为TC在NAFLD和NASH治疗中的潜在应用提供了科学依据，鼓励了该领域的进一步研究和发展。

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引用次数: 0

Comparative evaluation of the clinical efficacy of triple therapy and the addition use of TCM in treating Helicobacter pylori-associated gastritis 三联疗法与中药加用治疗幽门螺杆菌相关性胃炎的临床疗效比较

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-06-02 DOI: 10.1016/j.hermed.2025.101034

Mengli Xiao , Liying Zhang , Beihua Zhang , Liqun Bian , Zhenhua Li , Junxiang Li , Wei Wei , Min Liu , Li Liu , Chuijie Wang , Shaohong Shi , Jinkang Xu , Sheng Xie , Hong Shen , Qiang Yang , Guangjun Yan , Mingqi Wen , Fang Lu , Xudong Tang

Introduction

Traditional Chinese Medicine (TCM) has been found to be effective in the treatment of Helicobacter pylori (H. pylori). However, the quality of evidence is limited and there are few studies on TCM of H. pylori. This trials aimed to examine whether additional use of TCM can lead to better efficacy in the eradication rate of H. pylori.

Methods

This study consisted of a multicenter randomized controlled trial and a nonrandomized cohort. Subjects from TCM hospitals were allocated to a treatment group that received triple therapy or a combination group that received triple therapy combined with 2 weeks of herbal bulk or 2 weeks of herbal soup or 4 weeks of herbal soup. Patients in western hospitals received triple therapy (non-randomized control group). The eradication rate of H. pylori, the recurrence rate, the TCM symptom score, the patient-reported outcome scale (PRO), and safety indicators were observed and compared.

Results

960 patients screened, 768 were randomly assigned to the randomized treatment group, and 192 were assigned to the non-randomized group. No difference in the H. pylori eradication rate between the combination group compared with triple therapy (P > 0.05). Significant improvements were observed in TCM symptom scores, the quality of life in the combination group (P < 0.05). Moreover, it had a lower incidence of adverse reactions and rates of H. pylori recurrence (P < 0.05).

Conclusion

The additional use of TCM in triple therapy improves the quality of life, reduces adverse effects, and recurrence rates.

中药（TCM）已被发现对治疗幽门螺杆菌（H. pylori）有效。然而，证据质量有限，关于幽门螺杆菌的中医研究很少。本试验旨在检验额外使用中药是否能提高幽门螺杆菌的根除率。方法本研究由多中心随机对照试验和非随机队列组成。将来自中医院的受试者分为三联治疗组和联合治疗组，分别采用三联治疗加2周药汤或2周药汤或4周药汤治疗。西方医院患者采用三联疗法（非随机对照组）。观察并比较两组幽门螺杆菌根除率、复发率、中医症状评分、患者报告结局量表（PRO）及安全性指标。结果960例患者中，768例随机分为随机治疗组，192例随机分为非随机组。联合治疗组与三联治疗组幽门螺杆菌根除率无差异(P >；0.05)。联合用药组患者中医症状评分、生活质量均有显著改善(P <；0.05)。而且不良反应发生率和幽门螺杆菌复发率较低(P <；0.05)。结论在三联疗法中加用中药可提高患者的生活质量，减少不良反应，降低复发率。

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引用次数: 0

Exploring antiepileptic phytochemicals of Ferula assafoetida and underlying molecular mechanism using a combined approach of network pharmacology and molecular docking 运用网络药理学与分子对接相结合的方法探索阿魏抗癫痫植物化学成分及其分子机制

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-05-29 DOI: 10.1016/j.hermed.2025.101033

Naman Kapoor , Harsh Kashyap , Deepak Ganjewala , Hina Bansal

Introduction

Epilepsy is a prevalent and devastating neurological disorder that affects 1–2% of the global population particularly in low- and middle-income countries. There is a growing interest in exploring plant-based alternative therapies for epilepsy as none of the available anti-epileptic drugs provide complete prevention. This study aimed to investigate the bioactive compounds from Ferula assafoetida using computational approach to assess their potential antiepileptic activity and elucidate the mechanisms involved.

Methods

First, phytochemical data was extracted from IMPPAT database and mapped with PubChem. Then obtained their absorption and distribution patterns using SwissADME. Therapeutic targets associated with epilepsy were recognised using Swiss Target Prediction and GeneCards database. The target-network was constructed and performed topological, gene ontology and pathway enrichment analysis. Finally, molecular docking was performed.

Results

Three key bioactive constituents ferocolicin, luteolin, and farnesiferol with potential anti-epileptic activities were identified. These compounds influenced epileptogenesis by targeting proteins GABRA1, GABRA5, GRIN2B, MTOR, PTPRB, and CHRNA4. Molecular docking revealed stable binding of key constituents with three target proteins related to epileptogenesis. The order of binding affinities of the top three compounds to their respective targets was ferocolicin > farnesiferol > luteolin. This suggested a potentially higher therapeutic efficacy and target specificity of these compounds as compared to standard, valproic acid.

Conclusion

F. assafoetida could be utilised in the treatment of epilepsy by modulating epileptogenesis pathways. The study endorsed the importance of the efficacy of multicomponent, multi-target compound therapies decoding new therapeutic targets for epilepsy and related conditions.

癫痫是一种普遍存在的破坏性神经系统疾病，影响全球1-2%的人口，特别是在低收入和中等收入国家。由于没有一种可用的抗癫痫药物能完全预防癫痫，人们对探索基于植物的癫痫替代疗法的兴趣日益浓厚。本研究旨在利用计算方法研究阿魏的生物活性成分，评估其潜在的抗癫痫活性，并阐明其作用机制。方法首先从IMPPAT数据库中提取植物化学数据，并利用PubChem软件进行制图。然后用SwissADME获得了它们的吸收和分布模式。使用Swiss Target Prediction和GeneCards数据库识别与癫痫相关的治疗靶点。构建目标网络并进行拓扑分析、基因本体分析和途径富集分析。最后进行分子对接。结果鉴定出三种具有抗癫痫活性的关键生物活性成分铁霉素、木犀草素和法尼铁酚。这些化合物通过靶向GABRA1、GABRA5、GRIN2B、MTOR、PTPRB和CHRNA4蛋白影响癫痫发生。分子对接揭示了关键成分与癫痫发生相关的三种靶蛋白的稳定结合。前三位化合物与各自靶标的结合亲和力依次为：铁霉素；farnesiferol祝辞毛地黄黄酮。这表明与标准丙戊酸相比，这些化合物可能具有更高的治疗效果和靶向特异性。刺麻可通过调节癫痫发生途径用于治疗癫痫。该研究认可了多组分、多靶点复合疗法对癫痫及相关疾病的新治疗靶点的重要性。

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引用次数: 0

Piper betel L. Leaf Extract Lozenges for Preventing Dental Caries for Children 槟榔叶提取物预防儿童龋齿含片

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-05-24 DOI: 10.1016/j.hermed.2025.101032

Desy Nawangsari , Tatiana Siregar , Ikhwan Yuda Kusuma

Introduction

Dental caries in children remains a significant public health concern, primarily caused by plaque-forming bacteria such as Streptococcus mutans. Effective antimicrobial alternatives from natural sources are increasingly explored to address this issue.

Methods

This study evaluated the antibacterial activity of Piper betel L. (PB) leaf extract against Streptococcus mutans using the agar diffusion method. PB extract was obtained via ethanol maceration and formulated into lozenges with varying binder types and concentrations. The formulations were assessed for inhibition zone diameter and key physical parameters such as tablet uniformity, friability, hardness, and disintegration time.

Results

Piper betel L. extract demonstrated strong antibacterial activity, with the 7.5% concentration yielding an inhibition zone of 22.76 mm, comparable to that of 10%. Lozenges containing 7.5% PB extract exhibited acceptable physicochemical properties across all formulations, with disintegration times under 9 minutes, friability below 0.1%, and tablet hardness ranging from 48.67 to 77.09 N.

Conclusions

Piper betel L. leaf extract formulated as lozenges demonstrates significant antimicrobial potential for preventing dental caries, supported by effective inhibition of Streptococcus mutans and acceptable pharmaceutical properties.

儿童龋齿仍然是一个重大的公共卫生问题，主要由菌斑形成细菌如变形链球菌引起。人们越来越多地探索天然来源的有效抗菌替代品来解决这一问题。方法采用琼脂扩散法研究槟榔叶提取物对变形链球菌的抑菌活性。通过乙醇浸渍得到PB提取物，并配制成不同粘结剂类型和浓度的含片。考察了各配方的缓蚀带直径、均匀性、脆性、硬度、崩解时间等关键物理参数。结果槟榔提取物具有较强的抑菌活性，7.5%浓度的抑菌带为22.76 mm，与10%浓度的抑菌带相当。含7.5% PB提取物的含片在所有配方中均表现出可接受的理化性质，崩解时间在9 分钟以下，脆度在0.1%以下，片剂硬度在48.67 ~ 77.09 N之间。结论槟榔叶提取物作为含片具有明显的抗龋作用，对变形链球菌有较好的抑制作用，具有良好的药理作用。

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引用次数: 0

TCM formulas for strengthening the spleen, tonifying Qi, and supplementing the marrow in the treatment of MG: A network meta-analysis 健脾益气益髓治疗MG的中药方剂：网络荟萃分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-05-22 DOI: 10.1016/j.hermed.2025.101030

Chang Guan , Jian Wang , Peng Xu

Introduction

Myasthenia gravis is an autoimmune disease that primarily affects the acetylcholine receptors on the postsynaptic membrane at the neuromuscular junction. Traditional Chinese medicine (TCM) TSQNM formulas have been widely utilized in clinical practice and have shown effectiveness in treating Myasthenia gravis. There is a broad spectrum of TCM formulas with varying effectiveness, but there is a lack of direct comparative evidence between them. Bayesian network meta-analysis was utilized to evaluate the clinical efficacy and safety of TCM formulations that focus on spleen tonification, qi enhancement, and marrow nourishment (referred to as TSQNM) for treating myasthenia gravis. The results are anticipated to provide valuable insights into the treatment of myasthenia gravis.

Methods

Pertinent randomized controlled trials were retrieved from databases from the inception of the databases to October 17, 2023. The quality of studies was assessed using the risk of bias assessment tool developed by the Cochrane Collaboration. It was also preregistered in PROSPERO (ID: CRD42023482260). Network meta-analysis was conducted using STATA16 and R4.2.3.

Results

Twenty studies were included, involving 1 473 participants, with 739 cases in the experimental group and 734 cases in the control group. These studies examined the effectiveness of eight TCM formulas.

Conclusions

Combining conventional Western medicine treatment with TSQNM formulas has been shown to provide superior therapeutic effects for patients with myasthenia gravis, compared to using prescription drugs alone. Notably, when Buzhong Yiqi Decoction is combined with conventional Western medicine treatment, it has shown remarkable efficacy in reducing hormone-induced obesity and gastrointestinal tract discomfort.

重症肌无力是一种自身免疫性疾病，主要影响神经肌肉连接处突触后膜上的乙酰胆碱受体。中药复方TSQNM在治疗重症肌无力方面已被广泛应用于临床，并显示出良好的疗效。中药方剂种类繁多，疗效各异，但缺乏它们之间的直接比较证据。采用贝叶斯网络meta分析评价健脾益气益髓中药方剂（简称TSQNM）治疗重症肌无力的临床疗效和安全性。该结果有望为重症肌无力的治疗提供有价值的见解。方法从数据库建立至2023年10月17日的随机对照试验中检索。使用Cochrane Collaboration开发的偏倚风险评估工具评估研究的质量。它还在PROSPERO （ID: CRD42023482260）中进行了预注册。采用STATA16和R4.2.3进行网络meta分析。结果共纳入20项研究，共纳入受试者1 473例，其中实验组739例，对照组734例。这些研究检验了八种中药方剂的有效性。结论传统西药联合中药复方对重症肌无力患者的治疗效果优于单用处方药。值得注意的是，补中益气汤与西医常规治疗相结合，对减轻激素性肥胖和胃肠道不适有显著疗效。

{"title":"TCM formulas for strengthening the spleen, tonifying Qi, and supplementing the marrow in the treatment of MG: A network meta-analysis","authors":"Chang Guan , Jian Wang , Peng Xu","doi":"10.1016/j.hermed.2025.101030","DOIUrl":"10.1016/j.hermed.2025.101030","url":null,"abstract":"<div><h3>Introduction</h3><div>Myasthenia gravis is an autoimmune disease that primarily affects the acetylcholine receptors on the postsynaptic membrane at the neuromuscular junction. Traditional Chinese medicine (<strong>TCM</strong>) TSQNM formulas have been widely utilized in clinical practice and have shown effectiveness in treating Myasthenia gravis. There is a broad spectrum of TCM formulas with varying effectiveness, but there is a lack of direct comparative evidence between them. Bayesian network meta-analysis was utilized to evaluate the clinical efficacy and safety of TCM formulations that focus on spleen tonification, qi enhancement, and marrow nourishment (referred to as TSQNM) for treating myasthenia gravis. The results are anticipated to provide valuable insights into the treatment of myasthenia gravis.</div></div><div><h3>Methods</h3><div>Pertinent randomized controlled trials were retrieved from databases from the inception of the databases to October 17, 2023. The quality of studies was assessed using the risk of bias assessment tool developed by the Cochrane Collaboration. It was also preregistered in PROSPERO (ID: CRD42023482260). Network meta-analysis was conducted using STATA16 and R4.2.3.</div></div><div><h3>Results</h3><div>Twenty studies were included, involving 1 473 participants, with 739 cases in the experimental group and 734 cases in the control group. These studies examined the effectiveness of eight TCM formulas.</div></div><div><h3>Conclusions</h3><div>Combining conventional Western medicine treatment with TSQNM formulas has been shown to provide superior therapeutic effects for patients with myasthenia gravis, compared to using prescription drugs alone. Notably, when Buzhong Yiqi Decoction is combined with conventional Western medicine treatment, it has shown remarkable efficacy in reducing hormone-induced obesity and gastrointestinal tract discomfort.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"52 ","pages":"Article 101030"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of traditional Chinese medicine fumigation plus Yang-He decoction for patients with ankylosing spondylitis: systematic review and network meta-analysis 中药熏洗加养和汤治疗强直性脊柱炎的疗效：系统评价与网络meta分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-05-22 DOI: 10.1016/j.hermed.2025.101031

Xuan Li , Peng Dai , Jing Mao , Jiewen Deng , Yunnan Li

Introduction

To compare and rank the therapeutic effects of traditional Chinese medicine fumigating (TCMF) plus Yang-He decoction (YHD), TCMF plus acupuncture, TCMF, YHD, acupuncture, and Western medicine (WM) in patients with ankylosing spondylitis (AS).

Methods

The PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang, and VIP electronic databases were searched for eligible randomised controlled trials (RCTs) from their inception until April 2023. The primary endpoint was the efficacy rate.

Results

Nineteen RCTs involving 1 432 AS patients were selected. The surface under the cumulative ranking (SUCRA) probabilities indicated TCMF plus acupuncture (SUCRA: 78%) and TCMF plus YHD (SUCRA: 71%) exhibited relatively better efficacy. TCMF plus WM versus WM yielded a lower Visual Analogue Scale (VAS) score (P = 0.043), shorter morning stiffness time (MST) (P = 0.002), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (P = 0.003). Moreover, YHD plus WM versus WM was associated with a lower VAS score (P < 0.001), finger-floor distance (P < 0.001), pillow-wall distance (PWD) (P = 0.001), Bath Ankylosing Spondylitis Functional Index (BASFI) (P = 0.001), erythrocyte sedimentation rate (P < 0.001), or C-reactive protein (CRP) (P < 0.001), elevated Schober test (P < 0.001), thoracic expansion (P < 0.001), spinal column activity (SCA) (P < 0.001), and shorter MST (P < 0.001). TCMF plus YHD versus WM achieved a lower VAS score (P = 0.002), BASDAI (P < 0.001), BASFI (P < 0.001) or CRP (P = 0.038), and elevated SCA (P = 0.002). TCMF plus acupuncture versus WM showed lower VAS score (P < 0.001) and BASFI (P < 0.001). Finally, TCMF plus acupuncture versus acupuncture showed lower PWD (P = 0.004) and CRP (P = 0.031).

Conclusion

TCMF plus acupuncture and TCMF plus YHD provided better therapeutic effects in patients with AS.

目的比较中药熏洗加养和汤、中药熏洗加针灸、中药熏洗加养和汤、针灸加西医治疗强直性脊柱炎（AS）的疗效并进行排序。方法检索PubMed、Embase、Cochrane图书馆、中国国家知识基础设施、万方和VIP电子数据库自成立至2023年4月的符合条件的随机对照试验（RCTs）。主要终点是有效率。结果共纳入19项随机对照试验，共纳入AS患者1 432例。表面下累积排序概率（SUCRA）显示，TCMF +针刺（SUCRA: 78%）和TCMF + YHD （SUCRA: 71%）的疗效相对更好。与WM相比，TCMF加WM的视觉模拟评分（VAS）较低（P = 0.043），晨僵时间（MST）较短（P = 0.002），浴强直性脊柱炎疾病活动指数（BASDAI）较短（P = 0.003）。此外，YHD + WM与WM相比与较低的VAS评分相关(P <；0.001)，指底距离(P <；0.001)，枕壁距离（PWD）（P = 0.001），浴缸强直性脊柱炎功能指数（BASFI）（P = 0.001），红细胞沉降率(P <；0.001)或c反应蛋白（CRP） (P <；0.001)， Schober检验升高(P <；0.001)，胸廓扩张(P <；0.001)，脊柱活动（SCA） (P <；0.001)， MST较短(P <；0.001)。TCMF + YHD与WM相比，VAS评分较低（P = 0.002）， BASDAI (P <；0.001), BASFI (P <；0.001)或CRP (P = 0.038)， SCA升高（P = 0.002）。中西医结合治疗与中西医结合治疗VAS评分较低(P <；0.001)和BASFI (P <；0.001)。最后，中西医结合针刺与针刺相比，PWD （P = 0.004）和CRP （P = 0.031）均较低。结论中药加针刺、中药加YHD治疗AS疗效较好。

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引用次数: 0