Journal of Herbal Medicine最新文献_第4页

Efficacy of aromatherapy for reducing nausea and vomiting of pregnancy: a systematic review and meta-analysis 芳香疗法减轻妊娠期恶心呕吐的疗效：一项系统综述和荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-09-17 DOI: 10.1016/j.hermed.2025.101056

Farzaneh Safajou , Marzieh Bagherinia , Kowsar Qaderi , Arezoo Haseli , Fereshteh Yazdani , Mohaddese Mortezapoor

Background

Nausea and vomiting of pregnancy (NVP) affect pregnant women's quality of life. Despite the availability of pharmacological therapeutics, many prefer non-pharmacological methods such as aromatherapy. This study systematically reviews the effectiveness of aromatherapy in reducing NVP.

Method

Articles were searched from the Cochrane Library, ClinicalTrials.gov, SCOPUS, Web of Science, PubMed, Embase, and ProQuest databases without restrictions on language or publication date, up to November 2024. All controlled clinical trials on aromatherapy's effect on reducing NVP were included. A meta-analysis with random-effects reported standardised mean differences (SMD) and 95% confidence intervals. Heterogeneity was assessed with the Cochrane Q test and I² statistic.

Results

Ten studies that met the inclusion criteria were included, and nine were used for meta-analysis. The results showed that aromatherapy significantly reduces the severity of NVP [SMD = −0.65 (95% CI: −1.08 to −0.21) and (I² = 82.78%, P = 0.00)]. Subgroup analysis based on nausea and vomiting assessment instrument, aromatherapy type, and intervention duration showed that used the Rhodes scale to measure NVP, the mean difference between the aromatherapy group and the control group was statistically significant [MD = −4.11 (95% CI: −7.23 to −0.99)]. Lavender aromatherapy had the greatest effect in reducing NVP [SMD = −1.28 (95% CI: −2.45 to −0.11)]. Shorter aromatherapy (3–4 days) was more effective than a 7-day one in reducing NVP. [SMD = −0.73 (95% CI: −1.27 to −0.19)]. No publication bias was indicated (P = 0.576).

Conclusion

This meta-analysis supports the efficacy of aromatherapy as a non-pharmacological method for reducing NVP.

妊娠期恶心呕吐（NVP）影响孕妇的生活质量。尽管有药物治疗方法，但许多人更喜欢非药物方法，如芳香疗法。本研究系统回顾了芳香疗法降低NVP的有效性。方法从Cochrane Library、ClinicalTrials.gov、SCOPUS、Web of Science、PubMed、Embase和ProQuest数据库中检索文章，不受语言和出版日期的限制，截止到2024年11月。所有关于芳香疗法降低NVP效果的对照临床试验均被纳入。随机效应荟萃分析报告了标准化平均差异（SMD）和95%置信区间。采用Cochrane Q检验和I²统计量评估异质性。结果纳入符合纳入标准的10项研究，其中9项用于meta分析。结果显示，芳香疗法可显著降低NVP的严重程度[SMD = - 0.65 （95% CI: - 1.08 ~ - 0.21）和（I2 = 82.78%, P = 0.00）]。基于恶心呕吐评估工具、芳香疗法类型和干预时间的亚组分析显示，使用Rhodes量表测量NVP，芳香疗法组与对照组的平均差异有统计学意义[MD = - 4.11 (95% CI: - 7.23 ~ - 0.99)]。薰衣草芳香疗法在降低NVP方面效果最大[SMD = - 1.28 (95% CI: - 2.45至- 0.11)]。较短的芳香疗法（3-4天）在降低NVP方面比7天更有效。[SMD = - 0.73 (95% CI: - 1.27 ~ - 0.19)]。未发现发表偏倚（P = 0.576）。结论本荟萃分析支持芳香疗法作为一种非药物方法降低NVP的有效性。

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引用次数: 0

Network pharmacology-based analysis of Cornus officinalis for anti-osteoporosis property and experimental validation of its active component beta-sitosterol 基于网络药理学的山茱萸抗骨质疏松性分析及其有效成分-谷甾醇的实验验证

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-10-25 DOI: 10.1016/j.hermed.2025.101070

Xiaoming Gao , Chao Lin , Weimin Ren , Yanming Hao , Yiran Lu , Guoning Zhang , Nuo Chen , Qingsong Zou , Xiaoxiao Li , Qian Cheng

Introduction

Cornus officinalis is a commonly used herbal for osteoporosis. We aimed to explore the potential mechanism of Cornus officinalis in the treatment of postmenopausal osteoporosis using network pharmacology.

Methods

The active ingredients and targets of Cornus officinalis were screened from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and Uniprot database, and the predictive targets of postmenopausal osteoporosis were screened through the GeneCards database. The intersected targets of Cornus officinalis and disease were then obtained. Cytoscape 3.7.2 software was used to construct a traditional Chinese medicine-component-disease-target regulatory network. The DAVID database was used to analyze the gene ontology (GO) enrichment and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway annotation. The effect and mechanism of potential active ingredients of Cornus officinalis on postmenopausal osteoporosis were verified by cell experiments in vitro.

Results

Twelve active ingredients of Cornus officinalis and 30 effective targets in the treatment of postmenopausal osteoporosis were screened out. Among them, PTGS2, PTGS1 and ADRB2 might play a crucial role. Experiments have shown that beta-sitosterol increases the expression levels of OPN and RUNX2 in bone marrow mesenchymal stem cells. PTGS2 and TNF-α are two of the 30 potential target genes, and beta-sitosterol can decrease the expression of PTGS2 and TNF-α. Additionally, beta-sitosterol can increase the activity of alkaline phosphatase (ALP) and mineralisation in bone marrow mesenchymal stem cells (BMSCs).

Conclusion

The mechanism by which Cornus officinalis treats postmenopausal osteoporosis may involve active ingredients like beta-sitosterol acting on PTGS2 and TNF-α. The results of this study provide a theoretical basis for further research into the complex anti-osteoporosis mechanisms of Cornus officinalis.

山茱萸是治疗骨质疏松症的常用草药。我们旨在利用网络药理学方法探讨山茱萸治疗绝经后骨质疏松的潜在机制。方法从中药系统药理学（TCMSP）数据库和Uniprot数据库中筛选山茱萸的有效成分和靶点，通过GeneCards数据库筛选山茱萸对绝经后骨质疏松症的预测靶点。得到山茱萸与病害的交叉靶点。采用Cytoscape 3.7.2软件构建中药-成分-疾病靶点调控网络。使用DAVID数据库分析基因本体（GO）富集和京都基因与基因组百科全书（KEGG）通路注释。通过体外细胞实验验证山茱萸潜在有效成分对绝经后骨质疏松症的作用及机制。结果筛选出山茱萸12种有效成分和30个治疗绝经后骨质疏松症的有效靶点。其中，PTGS2、PTGS1和ADRB2可能起着至关重要的作用。实验表明-谷甾醇可增加骨髓间充质干细胞中OPN和RUNX2的表达水平。PTGS2和TNF-α是30个潜在靶基因中的两个，β -谷甾醇可以降低PTGS2和TNF-α的表达。此外，β -谷甾醇可以增加骨髓间充质干细胞（BMSCs）碱性磷酸酶（ALP）的活性和矿化。结论山茱萸治疗绝经后骨质疏松的机制可能与β -谷甾醇等有效成分对PTGS2和TNF-α的作用有关。本研究结果为进一步研究山茱萸复杂的抗骨质疏松机制提供了理论基础。

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引用次数: 0

GC-MS based comparative phytochemical profiling with anti-acne and antidermatophytic activities of commercial and organic tea tree oils 基于GC-MS的商业茶树油和有机茶树油抗痤疮和抗皮肤真菌活性的比较植物化学分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-10-14 DOI: 10.1016/j.hermed.2025.101064

Sultan Pekacar , Imge Ece Göçmen İlhan , Mine Kürkçüoğlu , Berrin Özçelik , Didem Deliorman Orhan

Introduction

Tea tree oil (TTO), mainly derived from Melaleuca alternifolia, is widely used in herbal medicine for its antimicrobial effects, particularly in treating acne and dermatophytic infections. With increasing clinical use, ensuring TTO quality is essential for efficacy and safety. This study aimed to evaluate the quality and antimicrobial, anti-acne, and antidermatophytic activities of commercially available TTO.

Methods

Twelve commercial TTO obtained from pharmacies, herbal stores, and health product retailers, along with one organic pure TTO reference, were analyzed following the European Pharmacopoeia 8.0 monograph criteria. Quality assessments included visual inspection, solubility and staining tests, thin-layer chromatography, and gas chromatography-mass spectrometry (GC-MS). Antimicrobial activities were tested against Cutibacterium acnes ATCC 6919 and dermatophyte strains Trichophyton rubrum RSKK 486, Epidermophyton floccosum RSKK 3027, and Microsporum gypseum NCPF 580 using standard microbiological methods.

Results

Only the organic TTO complied with the compositional requirements of the European Pharmacopoeia (EP) monograph, based on GC-MS analysis. Commercial samples showed significant deviations in chemical composition and physicochemical properties, exhibiting markedly lower antimicrobial and antidermatophytic activities compared to the organic reference.

Conclusion

This study shows only the organic TTO fulfilled ISO standards and EP compositional requirements, with notably higher antimicrobial activity against dermatophytes and C. acnes. These findings reveal concerns about the quality and potential adulteration of commercial TTO products. Ensuring product authenticity and adherence to standards is critical for their safe and effective use in managing acne and dermatophytosis. Strengthened quality control and regulatory measures are necessary to protect public health and support therapeutic applications.

茶树油（TTO）主要来源于互花千层树，因其抗菌作用而被广泛用于草药中，特别是治疗痤疮和皮肤真菌感染。随着临床应用的增加，确保TTO质量对疗效和安全性至关重要。本研究旨在评价市售白托的质量及其抗菌、抗痤疮和抗皮肤真菌活性。方法采用欧洲药典8.0专著标准，对从药店、草药商店和保健品零售商处获得的12种市售TTO及1种有机纯TTO对照品进行分析。质量评估包括目视检查、溶解度和染色试验、薄层色谱和气相色谱-质谱（GC-MS）。采用标准微生物学方法对痤疮角质杆菌ATCC 6919、红毛癣菌RSKK 486、絮状表皮菌RSKK 3027、石膏小孢子菌NCPF 580进行抑菌活性测定。结果经气相色谱-质谱分析，只有有机TTO符合欧洲药典（EP）各论的成分要求。商业样品在化学成分和理化性质上表现出明显的差异，与有机参比相比，抗菌和抗皮肤病活性明显较低。结论有机TTO符合ISO标准和EP成分要求，对皮肤癣菌和痤疮菌具有较高的抑菌活性。这些发现揭示了对商业TTO产品的质量和潜在掺假的担忧。确保产品的真实性和遵守标准是至关重要的，他们的安全和有效的使用管理痤疮和皮肤癣。必须加强质量控制和监管措施，以保护公众健康和支持治疗应用。

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引用次数: 0

Green synthesis of Betula pendula Roth. mediated silver nanoparticles and their cytotoxic effect on MCF-7 and MCF-12A cell lines 白桦的绿色合成。介导的银纳米颗粒及其对MCF-7和MCF-12A细胞系的细胞毒性作用

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.hermed.2025.101068

Nurgül KOÇAK , Ramazan CEYLAN , Emine ARSLAN , Büşra ÖZÇAY EKŞİ , Gözde KOYGUN

Introduction

Breast cancer is the most common type of cancer among women, and despite the current therapeutics, patient survival remains unsatisfactory. Furthermore, due to the side effects of these traditional treatments (such as surgery, chemotherapy, and radiotherapy), there is an urgent need for innovative strategies in the treatment of breast cancer. Green-synthesised nanoparticles (NPs) are among the most promising new approaches. Therefore, in this study, we aimed to describe the biofabrication of silver nanoparticles (AgNPs) using Betula pendula Roth leaf extract (Bp.E) and evaluate their selective biological effects on MCF-7 and MCF-12A cell lines.

Methods

The purity, size, and shape of biosynthesized AgNPs with Bp.E were characterised using Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), and X-ray diffraction (XRD). The selective anticancer potential of AgNPs was detected using the XTT assay.

Results

The anticancer activity of nanoparticles containing aromatic (CC, –CH) and plant-derived phenolic –OH groups and characterised as having a spherical structure with an average size of 32 nm was evaluated by the XTT method. The synthesised AgNPs exhibited a higher cytotoxic effect on MCF-7 than Bp.E. Furthermore, the synthesised AgNPs were determined to show selective cytotoxic activity against cancer cells compared to healthy cells.

Conclusion

In conclusion, the synthesised AgNPs represent a cost-effective and environmentally friendly biomaterial candidate, with clear potential for evaluation as an anticancer agent. Moreover, the findings will highlight further studies using various cancer cell lines and in vivo models of the therapeutic potential and safety of this biomaterial.

乳腺癌是女性中最常见的癌症类型，尽管目前的治疗方法，患者的生存率仍然令人不满意。此外，由于这些传统治疗方法（如手术、化疗和放疗）的副作用，迫切需要创新的乳腺癌治疗策略。绿色合成纳米颗粒（NPs）是最有前途的新方法之一。因此，在本研究中，我们旨在描述用白桦叶提取物（Bp.E）生物制备银纳米粒子（AgNPs），并评估其对MCF-7和MCF-12A细胞系的选择性生物学效应。方法测定Bp生物合成AgNPs的纯度、大小和形状。利用傅里叶变换红外光谱（FTIR）、透射电子显微镜（TEM）和x射线衍射（XRD）对E进行了表征。采用XTT法检测AgNPs的选择性抗癌潜力。结果采用XTT法对含有芳香（CC, -CH）和植物源性酚-OH基团的球形纳米粒子的抗癌活性进行了评价，纳米粒子的平均尺寸为32 nm。合成的AgNPs对MCF-7的细胞毒作用高于bp - e。此外，与健康细胞相比，合成的AgNPs显示出对癌细胞的选择性细胞毒活性。综上所述，合成的AgNPs是一种具有成本效益和环境友好的候选生物材料，具有明确的抗癌潜力。此外，该研究结果将强调使用各种癌细胞系和体内模型进一步研究这种生物材料的治疗潜力和安全性。

{"title":"Green synthesis of Betula pendula Roth. mediated silver nanoparticles and their cytotoxic effect on MCF-7 and MCF-12A cell lines","authors":"Nurgül KOÇAK , Ramazan CEYLAN , Emine ARSLAN , Büşra ÖZÇAY EKŞİ , Gözde KOYGUN","doi":"10.1016/j.hermed.2025.101068","DOIUrl":"10.1016/j.hermed.2025.101068","url":null,"abstract":"<div><h3>Introduction</h3><div>Breast cancer is the most common type of cancer among women, and despite the current therapeutics, patient survival remains unsatisfactory. Furthermore, due to the side effects of these traditional treatments (such as surgery, chemotherapy, and radiotherapy), there is an urgent need for innovative strategies in the treatment of breast cancer. Green-synthesised nanoparticles (NPs) are among the most promising new approaches. Therefore, in this study, we aimed to describe the biofabrication of silver nanoparticles (AgNPs) using <em>Betula pendula</em> Roth leaf extract (Bp.E) and evaluate their selective biological effects on MCF-7 and MCF-12A cell lines.</div></div><div><h3>Methods</h3><div>The purity, size, and shape of biosynthesized AgNPs with Bp.E were characterised using Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), and X-ray diffraction (XRD). The selective anticancer potential of AgNPs was detected using the XTT assay.</div></div><div><h3>Results</h3><div>The anticancer activity of nanoparticles containing aromatic (C<img>C, –CH) and plant-derived phenolic –OH groups and characterised as having a spherical structure with an average size of 32 nm was evaluated by the XTT method. The synthesised AgNPs exhibited a higher cytotoxic effect on MCF-7 than Bp.E. Furthermore, the synthesised AgNPs were determined to show selective cytotoxic activity against cancer cells compared to healthy cells.</div></div><div><h3>Conclusion</h3><div>In conclusion, the synthesised AgNPs represent a cost-effective and environmentally friendly biomaterial candidate, with clear potential for evaluation as an anticancer agent. Moreover, the findings will highlight further studies using various cancer cell lines and <em>in vivo</em> models of the therapeutic potential and safety of this biomaterial.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"54 ","pages":"Article 101068"},"PeriodicalIF":1.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solanum nigrum berries HPLC fraction: compounds identification, ADMET analysis, and docking with MecA-PBP2 transpeptidase of methicillin-resistant Staphylococci 茄黑莓高效液相色谱：化合物鉴定、ADMET分析及与耐甲氧西林葡萄球菌MecA-PBP2转肽酶对接

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.hermed.2025.101066

Hina Hameed , Hazir Rahman , Tabassum Tabassum , Saghir Ahmad , Abdul Tawab , Khalid J. Alzahrani , Khalaf F. Alsharif , Fuad M. Alzahrani

Introduction

Plants have an important role in therapeutic medicines due to the presence of metabolites. Gradient high-performance liquid chromatography (HPLC) fractions of Solanum nigrum berry ethanol extracts were evaluated against methicillin-resistant Staphylococcus epidermidis (MRSE) and methicillin-resistant Staphylococcus aureus (MRSA) for potential druggable molecules.

Methods

Solanum nigrum berry ethanol extracts and HPLC fractions were processed for electrospray ionization mass spectrometry, ADMET, and docking analysis.

Results

Ethanol extracts of Solanum nigrum exhibited anti-MRSA and anti-MRSE activity. The active extracts were further subjected to gradient HPLC. Among the collected HPLC fractions (n = 37), F3 of the ethanol extract showed inhibitory activity against MRSA (15 ± 0.152 mm) and MRSE (17 ± 0.404 mm) and was processed for electrospray ionization mass spectrometry. Seven compounds, including meglutol, quinic acid, D-gluconic acid, malic acid, cis-4-coumeric acid, chlorogenic acid, and hexose polymer, were identified. The meglutol, quinic acid, and D-gluconic acid were for the first time reported in Solanum nigrum. ADMET analysis revealed meglutol, quinic acid, and D-gluconic acid as highly water-soluble molecules along with feasible pharmacokinetics and drug-likeness characteristics. Molecular docking showed that meglutol formed an association via THR-600, LYS-406, ASN-464, and quinic acid with ILE-427, GLY-429, and D-gluconic acid with GLU-447, THR-600, TYR-446 residues of MecA-PBP2 transpeptidase of MRSA and MRSE.

Conclusion

Solanum nigrum berries ethanol fraction (F3) exhibited anti-MRSA and anti-MRSE activity. Three compounds, including meglutol, quinic acid, and D-gluconic acid, displayed likely druggable characteristics and putative MecA-PBP2 inhibitors of MRSA and MRSE. Further validation of the identified compounds may help to characterise these compounds as therapeutic molecules.

植物由于其代谢产物的存在而在治疗药物中起着重要的作用。采用梯度高效液相色谱法（HPLC）评价了茄黑莓乙醇提取物的抗甲氧西林耐药表皮葡萄球菌（MRSE）和耐甲氧西林金黄色葡萄球菌（MRSA）的潜在药物分子。方法采用电喷雾质谱、ADMET、对接分析等方法对黑荆果乙醇提取物和高效液相色谱组分进行处理。结果龙葵乙醇提取物具有抗mrsa和抗mrse活性。对活性提取物进行梯度高效液相色谱分析。所得高效液相色谱（n = 37）中，乙醇提取物F3对MRSA（15±0.152 mm）和MRSE（17±0.404 mm）具有抑制活性，并进行电喷雾电离质谱分析。共鉴定出葡萄糖醇、奎宁酸、d -葡萄糖酸、苹果酸、顺式-4-香丁酸、绿原酸和己糖聚合物等7个化合物。葡萄糖醇、奎宁酸和d -葡萄糖酸均为首次在茄属植物中报道。ADMET分析显示葡萄糖醇、奎宁酸和d -葡萄糖酸是高水溶性分子，具有可行的药代动力学和药物相似特性。分子对接表明，meglutol通过THR-600、LYS-406、ASN-464和奎宁酸与ILE-427、GLY-429、d -葡萄糖酸与MRSA和MRSE的MecA-PBP2转肽酶的GLU-447、THR-600、TYR-446残基形成关联。结论茄果乙醇提取物（F3）具有抗mrsa和抗mrse活性。三种化合物，包括葡萄糖醇、奎宁酸和d -葡萄糖酸，显示出可能的药物特性和假定的MRSA和MRSE的MecA-PBP2抑制剂。进一步验证所鉴定的化合物可能有助于将这些化合物表征为治疗分子。

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引用次数: 0

Phytochemical constituents, and antioxidant, antidiabetic and anti-inflammatory activities of the extracts from Pandanus amaryllifolius Roxb. 香豆提取物的植物化学成分及抗氧化、抗糖尿病和抗炎活性研究。

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1016/j.hermed.2025.101062

Nopparat Buddhakala , Butsara Yongkhamcha

Introduction

This study was aimed to determine phytochemical constituents, and antioxidant, antidiabetic and anti-inflammatory activities of the leaf extracts from Pandanus amaryllifolius and verify whether extracting solvents and concentrations, and age of leaves influence phytochemicals and activities of the extracts.

Methods

Mature leaves were extracted with 50% or 95% ethanol. Young, medium, and mature leaves were extracted with 80 °C or 100 °C distilled water. Liquid Chromatography-Mass Spectroscopy (LC-MS) and phytochemical screening, evaluation of total phenolic content (TPC) and total flavonoid content (TFC) along with 2,2-diphenyl-1-picrylhydrazyl (radical scavenging assay) (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (radical cation assay) (ABTS) and ferric reducing antioxidant power (FRAP) assays, α-glucosidase and α-amylase assays, and Griess assay were employed for determination of phytochemical constituents, antioxidant, antidiabetic and anti-inflammatory activities, respectively.

Results

LC-MS analysis revealed 61 compounds in 50% ethanol extract and 94 compounds in the 95% ethanol extract. Quercetin 3-galactoside was the most predominant compound in the 50% ethanol extract, and saponarin in the 95% ethanol extract. The 95% ethanol extract possessed higher antioxidant, antidiabetic and anti-inflammatory activities than the 50% ethanol extract. The water extracts contained phenolics, flavonoids, terpenoids, and saponins. The mature leaves extracted with 80 °C water exhibited the highest antidiabetic activity, in comparing to others.

Conclusions

The extracting solvents and concentrations as well as the leaf ages significantly influence the phytochemical constituents and the antioxidant, antidiabetic and anti-inflammatory activities of the extracts. The findings support the potential development of P. amaryllifolius extracts as functional ingredients for managing diseases related to oxidative stress, diabetes, and inflammation.

本研究旨在测定香豆叶提取物的植物化学成分、抗氧化、抗糖尿病和抗炎活性，并验证提取溶剂、提取浓度和叶龄对其植物化学成分和活性的影响。方法用50%或95%乙醇提取成熟叶。幼叶、中叶和成熟叶分别用80°C或100°C的蒸馏水提取。采用液相色谱-质谱（LC-MS）和植物化学筛选，评价总酚含量（TPC）和总黄酮含量（TFC），并采用2,2-二苯基-1-picrylhydrazyl（自由基清除试验）（DPPH）、2,2 ' -氮基-双（3-乙基苯并噻唑-6-磺酸）（自由基阳离子试验）（ABTS）和铁还原抗氧化能力（FRAP）试验、α-葡萄糖苷酶和α-淀粉酶试验以及Griess试验测定植物化学成分、抗氧化剂、分别具有抗糖尿病和抗炎活性。结果从50%乙醇提取物中分离出61种化合物，从95%乙醇提取物中分离出94种化合物。槲皮素3-半乳糖苷在50%乙醇提取物中含量最高，皂苷在95%乙醇提取物中含量最高。95%乙醇提取物比50%乙醇提取物具有更高的抗氧化、抗糖尿病和抗炎活性。水提取物含有酚类、黄酮类、萜类和皂苷。80°C水浸提的成熟叶抗糖尿病活性最高。结论提取溶剂、提取浓度、叶龄对黄芪提取物的化学成分及抗氧化、抗糖尿病、抗炎活性均有显著影响。这些发现支持了amaryllifolius提取物作为治疗氧化应激、糖尿病和炎症相关疾病的功能成分的潜在开发。

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引用次数: 0

Efficacy of combined Chinese and Western medicine in the treatment of hypothyroidism: a systematic review and network meta-analysis 中西医结合治疗甲状腺功能减退的疗效：系统评价和网络荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-09-09 DOI: 10.1016/j.hermed.2025.101055

Ma Yixuan , Yang Wenhui , Wang Huizhen , Zhai Mingming

Objective

To systematically evaluate combined Chinese and Western medicine for hypothyroidism, provide a reference for clinical treatment, and promote integrative medicine development in hypothyroidism treatment.

Methods

Randomised controlled trials (RCTs) of combined Chinese and Western medicine for the treatment of hypothyroidism were searched from CNKI, WanFang, SinoMed, PubMed, Web of Science, Cochrane Library, etc., from database inception to April 2024. Additionally, Network Meta-analysis was performed using Stata 17.

Results

A total of 59 papers involving 24 Traditional Chinese Medicine (TCM) interventions were included. Zhenqi Fuzheng capsules combined with conventional western medicines had significantly improved the total clinical effectiveness rate and free thyroxine (FT4); Xiaoying decoction combined with conventional western medicines had significantly reduced thyroid-stimulating hormone (TSH); acupuncture combined with conventional western medicines had significantly improved free triiodothyronine (FT3); Jianggui Yiying Prescription combined with Yougui pills combined with conventional western medicines had significantly reduced thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb); Yougui pills combined with conventional western medicines had significantly reduced triglyceride (TG); Zhenwu decoction combined with conventional western medicines had significantly raised high-density lipoprotein cholesterol (HDL-C), reduced total cholesterol (TC)/low-density lipoprotein cholesterol (LDL-C), and lowered TCMSS (Traditional Chinese Medicine Syndrome Score).The incidence rates and types of adverse reactions varied among different intervention measures.

Conclusion

Combined Chinese and Western medicine showed greater efficacy than Western medicine alone for hypothyroidism. Optimal regimens vary by clinical condition, and patients should select treatments accordingly. However, conclusions require further validation due to limited literature quality and quantity.

目的系统评价中西医结合治疗甲状腺功能减退的疗效，为临床治疗提供参考，促进中西医结合治疗甲状腺功能减退的发展。方法检索中国知网、万方、中国医学信息网、PubMed、Web of Science、Cochrane Library等数据库自建库至2024年4月期间中西医结合治疗甲状腺功能减退症的随机对照试验（RCTs）。此外，使用Stata 17进行网络meta分析。结果共纳入59篇文献，涉及24项中医干预措施。贞芪扶正胶囊联合常规西药可显著提高临床总有效率和游离甲状腺素（FT4）；小影汤联合常规西药可显著降低促甲状腺激素（TSH）；针刺联合西药治疗显著提高游离三碘甲状腺原氨酸（FT3）；姜桂益应方联合右桂丸联合常规西药可显著降低甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TGAb）；油桂丸联合常规西药可显著降低甘油三酯（TG）；真武汤联合西药治疗可显著提高高密度脂蛋白胆固醇（HDL-C），降低总胆固醇(TC)/低密度脂蛋白胆固醇（LDL-C），降低中医证候评分（TCMSS）。不同干预措施的不良反应发生率和类型不同。结论中西医结合治疗甲状腺功能减退的疗效优于单用西药。最佳方案因临床情况而异，患者应据此选择治疗方案。然而，由于文献质量和数量有限，结论需要进一步验证。

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引用次数: 0

Efficacy and safety of traditional Chinese medicine for post-infectious cough compared to placebo: a systematic review and meta-analysis 与安慰剂相比，中药治疗感染性咳嗽的疗效和安全性：一项系统综述和荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.hermed.2025.101059

Xinyi Zhang , Xin Jin , Jianning Guo , Hongchun Zhang

Introduction

Post-infectious cough (PIC) is a common form of cough with a high incidence rate, accounting for approximately 48.4% of subacute cough cases. Currently, there is no conclusive evidence indicating that pharmacological treatments exert a significant therapeutic effect on PIC, and standardised treatment protocols have yet to be established. This study aims to evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of PIC, providing a reference for clinical practice.

Methods

A comprehensive search was conducted across multiple databases. Randomised controlled trials (RCTs) investigating TCM interventions for PIC were retrieved, with the search covering all publications up to February 6, 2025. Risk of bias was assessed using the Cochrane Risk of Bias tool and meta-analysis was conducted using RevMan 5.4 software.

Results

A total of nine articles were included, comprising seven RCTs. The meta-analysis demonstrated that TCM was significantly more effective than placebo in reducing cough symptom scores, alleviating cough severity, lowering TCM syndrome scores, improving cough relief rate and resolution rate, and enhancing clinical efficacy rate. Moreover, no serious adverse events were reported. TCM may also contribute to shortening the time to cough relief and resolution. However, no statistically significant differences were observed in terms of quality of life improvement or recurrence rates of cough.

Conclusion

Compared with placebo, TCM treatment for PIC demonstrates superior clinical efficacy, improving cough symptoms and shortening the disease course, with good safety profiles.

感染后咳嗽（PIC）是一种常见的咳嗽形式，发病率高，约占亚急性咳嗽病例的48.4%。目前，没有确凿的证据表明药物治疗对PIC有显著的治疗效果，标准化的治疗方案尚未建立。本研究旨在评价中药治疗PIC的疗效和安全性，为临床实践提供参考。方法在多个数据库中进行综合检索。检索调查中药干预PIC的随机对照试验（RCTs），检索涵盖截至2025年2月6日的所有出版物。采用Cochrane风险偏倚工具评估偏倚风险，采用RevMan 5.4软件进行meta分析。结果共纳入9篇文章，包括7篇rct。meta分析显示，中药在降低咳嗽症状评分、减轻咳嗽严重程度、降低中医证候评分、提高咳嗽缓解率和治愈率、提高临床有效率等方面均显著优于安慰剂。此外，没有严重不良事件的报道。中医也有助于缩短咳嗽缓解和消退的时间。然而，在生活质量改善和咳嗽复发率方面，没有观察到统计学上的显著差异。结论中药治疗PIC临床疗效优于安慰剂，可改善咳嗽症状，缩短病程，且安全性较好。

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引用次数: 0

Antibacterial and antifungal effect of Salvadora persica L. root extract, essential oil, and nanoemulsion 木香根提取物、精油和纳米乳的抑菌抑菌作用

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.hermed.2025.101058

Mehrdad Yazdi , Javad Akhtari , Ali Davoodi , Iman Haghani , Zahra Kiadehi , Hamid Reza Goli

Introduction

Due to increasing antimicrobial resistance rates, this study aimed to evaluate the antibacterial and antifungal effect of the alcoholic extract, essential oil, and nanoemulsion prepared from Salvadora persica L. root.

Methods

Alcoholic extract of S. persica root and its essential oil were prepared by percolation and distillation methods, respectively. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) of the antimicrobials were determined against clinically significant bacteria and fungi.

Results

The alcoholic extract with a concentration of 6.25% inhibited Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Meanwhile, the essential oil had a better inhibitory effect on Staphylococcus aureus, Enterococcus faecalis, and Streptococcus mutans. Also, nanoemulsion was able to inhibit most Gram-negative bacteria (0.09%). The minimum bactericidal concentration of the extract was not appropriate, but the essential oil was able to kill the tested Gram-positive bacteria (12.5%). Also, nanoemulsion was able to kill Gram-negative bacteria (0.39%), except P. aeruginosa. Candida albicans and Aspergillus fumigatus were the most sensitive fungi to root extract, while the essential oil was able to inhibit all fungi (1.56%). Nanoemulsion was also able to inhibit all fungi (0.09%), except Aspergillus niger. In addition, the antifungal compounds showed a low minimum fungicidal concentration.

Conclusion

The nanoemulsion prepared from the S. persica root had more pronounced antibacterial and antifungal effects than the alcoholic extract and essential oil. However, these agents may be effective as adjuvants in the prevention or treatment of infections.

摘要：由于鼠尾草根的耐药率越来越高，本研究旨在评价鼠尾草根酒精提取物、精油和纳米乳的抗菌和抗真菌作用。方法采用浸透法和蒸馏法分别制备茴香根乙醇提取物和挥发油。测定抗菌药物对临床重要细菌和真菌的最小抑菌浓度（MIC）、最小杀菌浓度（MBC）和最小杀真菌浓度（MFC）。结果6.25%浓度的醇提物对铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌、变形杆菌均有抑制作用。同时，精油对金黄色葡萄球菌、粪肠球菌、变形链球菌均有较好的抑制作用。纳米乳对革兰氏阴性菌的抑制率为0.09%。精油对革兰氏阳性菌（12.5%）有一定的杀灭作用。除铜绿假单胞菌外，纳米乳对革兰氏阴性菌（0.39%）均有杀伤作用。根提取物对白色念珠菌和烟曲霉最敏感，对所有真菌均有抑制作用（1.56%）。纳米乳对除黑曲霉外的所有真菌均有抑制作用（0.09%）。此外，抗真菌化合物表现出较低的最低杀真菌浓度。结论木香根纳米乳的抑菌抑菌作用明显优于醇提物和挥发油。然而，这些药物在预防或治疗感染时可能作为佐剂有效。

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引用次数: 0

Comparative Effect of N-Acetylcysteine and Thyme Syrup on Arterial Blood Gases in Intubated ICU Patients: A Randomized Clinical Trial n -乙酰半胱氨酸与百里香糖浆对ICU插管患者动脉血气影响的随机临床试验

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-09-04 DOI: 10.1016/j.hermed.2025.101054

Mehdi Safarabadi , Hooman Mohammad Talebi , Mohammad Rostamkhani , Abolfazl Jokar , Masoud Etedali

Introduction

Tracheal intubation often causes mucus buildup, affecting arterial blood gas levels. N-acetylcysteine (NAC) is used to clear secretions. Also, thyme can alleviate respiratory symptoms. This study compares the effects of NAC and thyme extract on ABG levels in intubated intensive care unit (ICU) patients.

Methods

This randomized, double-blind clinical trial compared the effectiveness of herbal thyme syrup and intravenous NAC in 70 intubated patients in ICU. Participants were randomly assigned to receive either thyme syrup (2 g orally, twice daily for 5 days) or intravenous NAC. Both groups received standard airway secretion clearance techniques. Primary outcomes included ABG parameters (O₂, pH, HCO₃⁻, CO₂) and pulmonary secretion volume, recorded daily for 5 days. Statistical analysis was performed using SPSS v.22 with P < 0.05 considered significant.

Results

A total of 70 ICU patients were enrolled, with 35 patients in each treatment group. The Thyme group showed significantly higher oxygen levels (P < 0.001) and improved pH (P = 0.005) compared to the NAC group, while CO₂ levels were significantly lower in the Thyme group (P = 0.001). No significant differences were observed between the groups in terms of bicarbonate levels (P = 0.110). Exudate clearance did not show significant improvement in either group (P = 0.995). Baseline characteristics were balanced between the two groups, with no significant differences in age, gender, or smoking status.

Conclusions

Thyme concentrate may improve oxygenation, reduce CO2, and balance acid-base levels in ICU patients.

气管插管常引起粘液积聚，影响动脉血气水平。n -乙酰半胱氨酸（NAC）用于清除分泌物。此外，百里香还能缓解呼吸道症状。本研究比较了NAC和百里香提取物对插管重症监护病房（ICU）患者ABG水平的影响。方法本随机双盲临床试验比较中药百里香糖浆与静脉注射NAC对70例ICU插管患者的疗效。参与者被随机分配接受百里香糖浆（2 g口服，每天两次，连续5天）或静脉注射NAC。两组均采用标准气道分泌物清除技术。主要结果包括ABG参数（O₂，pH, HCO₃，CO₂）和肺分泌量，每天记录5天。采用SPSS v.22进行统计学分析，P值 <； 0.05为显著性。结果共纳入ICU患者70例，每个治疗组35例。与NAC组相比，百里香组显着提高了氧气水平（P <； 0.001），改善了pH值（P = 0.005），而CO₂水平在百里香组显着降低（P = 0.001）。两组间碳酸氢盐含量无显著差异（P = 0.110）。两组患者的渗出液清除率均无明显改善（P = 0.995）。基线特征在两组之间是平衡的，在年龄、性别或吸烟状况上没有显著差异。结论百里香浓缩液具有改善ICU患者氧合、降低CO2、平衡酸碱水平的作用。

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引用次数: 0