Journal of Herbal Medicine最新文献_第4页

Shenmai injection in treating chemotherapy-related cardiotoxicity of breast cancer: a systematic review and meta-analysis 神麦注射液治疗乳腺癌化疗相关心脏毒性：系统综述和荟萃分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-17 DOI: 10.1016/j.hermed.2024.100936

Ming Feng , Hong Huang , Chang Yao

Objective

Shenmai injection (SMI) is an established treatment for cardiac diseases, and we performed to evaluate the efficacy of SMI combined with chemotherapy drugs for the treatment of chemotherapy-induced cardiotoxicity.

Methods

The primary outcome was abnormal electrocardiogram (ECG), left ventricular ejection fraction (LVEF) and E/A. The secondary outcomes included myocardial injury biomarkers (creatine kinase [CK], creatine kinase MB [CK-MB], and cardiac troponin I [cTnI]) and lipid peroxide markers (superoxide dismutase [SOD], glutathione [GSH], and malondialdehyde [MAD]).

Results

Studies indicated that SMI combined with chemotherapy drugs has advantages over chemotherapy drugs alone in reducing the incidence of abnormal ECG (ST-T: RR = 0.613, 95% CI [0.437, 0.862], P = 0.005; extrasystole: RR = 0.527, 95% CI [0.349, 0.798], P = 0.002). Myocardial injury biomarkers in the experimental group were lower than those in the control group (CK: SMD = –2.614, 95% CI [–3.156, –2.071], P = 0.000; CK-MB: SMD = –6.882, 95% CI [–8.982, –4.782], P = 0.000; cTnI: SMD = –3.610, 95% CI [–4.949, –2.271], P = 0.000). Ultrasonic cardiogram analysis showed that the experimental group had a higher LVEF and E/A than the control group (LVEF: SMD = 1.572, 95% CI [1.176, 1.969], P = 0.000; E/A: SMD = 0.280, 95% CI [0.153, 0.407], P = 0.000). Lipid peroxide meta-analysis showed that the experimental group had higher SOD and GSH levels (SOD: weighted mean difference (WMD) = 39.783, 95% CI (32.524, 47.042), P = 0.000; GSH: WMD = 32.960, 95% CI [26.055, 39.865], P = 0.000), and lower malondialdehyde (MDA) (WMD = –4.962, 95% CI [–6.041, –3.883], P = 0.000).

Conclusion

SMI is effective in reducing cardiac injury and the incidence of cardiotoxicity.

方法主要结果是心电图（ECG）异常、左室射血分数（LVEF）和E/A。次要结果包括心肌损伤生物标志物（肌酸激酶[CK]、肌酸激酶MB[CK-MB]和心肌肌钙蛋白I[cTnI]）和过氧化脂质标志物（超氧化物歧化酶[SOD]、谷胱甘肽[GSH]和丙二醛[MAD]）。结果研究表明，SMI联合化疗药物在降低异常心电图（ST-T：RR=0.613，95% CI [0.437，0.862]，P=0.005；期外收缩：RR=0.527，95% CI [0.349，0.798]，P=0.002）。实验组心肌损伤生物标志物低于对照组（CK：SMD = -2.614，95% CI [-3.156，-2.071]，P = 0.000；CK-MB：SMD = -6.882，95% CI [-8.982，-4.782]，P = 0.000；cTnI：SMD = -3.610，95% CI [-4.949，-2.271]，P = 0.000）。超声心动图分析显示，实验组的 LVEF 和 E/A 均高于对照组（LVEF：SMD=1.572，95% CI [1.176，1.969]，P=0.000；E/A：SMD=0.280，95% CI [0.153，0.407]，P=0.000）。过氧化脂质荟萃分析表明，实验组的 SOD 和 GSH 水平更高（SOD：加权平均差（WMD）= 39.783，95% CI [32.524，47.042]，P = 0.000；GSH：WMD = 32.960，95% CI [26.结论SMI能有效降低心脏损伤和心脏毒性的发生率。

{"title":"Shenmai injection in treating chemotherapy-related cardiotoxicity of breast cancer: a systematic review and meta-analysis","authors":"Ming Feng , Hong Huang , Chang Yao","doi":"10.1016/j.hermed.2024.100936","DOIUrl":"10.1016/j.hermed.2024.100936","url":null,"abstract":"<div><h3>Objective</h3><div>Shenmai injection (SMI) is an established treatment for cardiac diseases, and we performed to evaluate the efficacy of SMI combined with chemotherapy drugs for the treatment of chemotherapy-induced cardiotoxicity.</div></div><div><h3>Methods</h3><div>The primary outcome was abnormal electrocardiogram (ECG), left ventricular ejection fraction (LVEF) and E/A. The secondary outcomes included myocardial injury biomarkers (creatine kinase [CK], creatine kinase MB [CK-MB], and cardiac troponin I [cTnI]) and lipid peroxide markers (superoxide dismutase [SOD], glutathione [GSH], and malondialdehyde [MAD]).</div></div><div><h3>Results</h3><div>Studies indicated that SMI combined with chemotherapy drugs has advantages over chemotherapy drugs alone in reducing the incidence of abnormal ECG (ST-T: RR = 0.613, 95% CI [0.437, 0.862], <em>P</em> = 0.005; extrasystole: RR = 0.527, 95% CI [0.349, 0.798], <em>P</em> = 0.002). Myocardial injury biomarkers in the experimental group were lower than those in the control group (CK: SMD = –2.614, 95% CI [–3.156, –2.071], <em>P</em> = 0.000; CK-MB: SMD = –6.882, 95% CI [–8.982, –4.782], <em>P</em> = 0.000; cTnI: SMD = –3.610, 95% CI [–4.949, –2.271], <em>P</em> = 0.000). Ultrasonic cardiogram analysis showed that the experimental group had a higher LVEF and E/A than the control group (LVEF: SMD = 1.572, 95% CI [1.176, 1.969], <em>P</em> = 0.000; E/A: SMD = 0.280, 95% CI [0.153, 0.407], <em>P</em> = 0.000). Lipid peroxide meta-analysis showed that the experimental group had higher SOD and GSH levels (SOD: weighted mean difference (WMD) = 39.783, 95% CI (32.524, 47.042), <em>P</em> = 0.000; GSH: WMD = 32.960, 95% CI [26.055, 39.865], <em>P</em> = 0.000), and lower malondialdehyde (MDA) (WMD = –4.962, 95% CI [–6.041, –3.883], <em>P</em> = 0.000).</div></div><div><h3>Conclusion</h3><div>SMI is effective in reducing cardiac injury and the incidence of cardiotoxicity.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100936"},"PeriodicalIF":2.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological applications of Urtica dioica: a comprehensive review of its traditional use and modern scientific evidence 荨麻的药理应用：对其传统用途和现代科学依据的全面回顾

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-12 DOI: 10.1016/j.hermed.2024.100935

Md Alimoddin , S. Jayakumari , Butool Fatima , Nadeem Hasan , Sadat Ali , Farheen Sami , Md Sajid Ali , Rajesh Sreedharan Nair , Mohammed Tahir Ansari

Introduction

This review article provides a comprehensive overview of the phytochemical constituents, traditional uses, and pharmacological applications of Urtica dioica (UD), commonly known as stinging nettle.

Methodology

An extensive literature search was conducted to identify 278 relevant articles. After eliminating 38 duplicates, we thoroughly analysed the remaining 240 articles by examining their titles and abstracts. Finally, 126 articles were selected for inclusion in this comprehensive study on UD.

Discussion

This review explores the plant identifiable characteristics, geographical distribution and taxonomic classification. The phytochemicals found in plants include sterols, fatty acids, alkaloids, terpenoids, flavonoids, lignans, and essential oils, all of which contribute to their medicinal and therapeutic properties. It exhibits a broad range of pharmacological activities including anti-inflammatory, hypoglycaemic, antiurolithiatic, neuroprotective, antioxidant, antimicrobial, antiproliferative, and anticancer effects. UD leaves contain high levels of antioxidants, which may be useful for the treatment of breast cancer by inducing apoptosis. UD extracts exert a protective function by regulating blood glucose levels and β-cell activity, exhibiting insulin-like effects. It also inhibits pro-inflammatory pathways and demonstrates hepatoprotective properties following hepatectomy. UD extract inhibits the proliferation and migration of cancer cells and displays antiviral activity against rotavirus and feline immunodeficiency virus. Furthermore, UD is effective in treating chronic conditions, such as prostatitis, dandruff, and osteoarthritis, thereby reducing the need for conventional medications.

Conclusion

The diverse uses and biological properties of UD make it a subject of interest for future research.

引言这篇综述文章全面概述了荨麻（俗称刺荨麻）的植物化学成分、传统用途和药理应用。方法通过广泛的文献检索，我们找到了 278 篇相关文章。在剔除了 38 篇重复文章后，我们对剩余的 240 篇文章的标题和摘要进行了深入分析。讨论本综述探讨了植物的可识别特征、地理分布和分类学分类。植物中的植物化学物质包括甾醇、脂肪酸、生物碱、萜类化合物、黄酮类化合物、木脂素和精油，所有这些物质都有助于提高植物的药用和治疗特性。它具有广泛的药理活性，包括抗炎、降血糖、抗尿酸盐、神经保护、抗氧化、抗菌、抗增殖和抗癌作用。UD 叶子含有大量抗氧化剂，可通过诱导细胞凋亡治疗乳腺癌。UD 提取物通过调节血糖水平和 β 细胞活性发挥保护功能，具有类似胰岛素的作用。它还能抑制促炎途径，并在肝切除术后显示出保护肝脏的特性。UD 提取物能抑制癌细胞的增殖和迁移，并对轮状病毒和猫免疫缺陷病毒具有抗病毒活性。此外，UD 还能有效治疗慢性疾病，如前列腺炎、头皮屑和骨关节炎，从而减少对传统药物的需求。

{"title":"Pharmacological applications of Urtica dioica: a comprehensive review of its traditional use and modern scientific evidence","authors":"Md Alimoddin , S. Jayakumari , Butool Fatima , Nadeem Hasan , Sadat Ali , Farheen Sami , Md Sajid Ali , Rajesh Sreedharan Nair , Mohammed Tahir Ansari","doi":"10.1016/j.hermed.2024.100935","DOIUrl":"10.1016/j.hermed.2024.100935","url":null,"abstract":"<div><h3>Introduction</h3><div>This review article provides a comprehensive overview of the phytochemical constituents, traditional uses, and pharmacological applications of <em>Urtica dioica</em> (UD), commonly known as stinging nettle.</div></div><div><h3>Methodology</h3><div>An extensive literature search was conducted to identify 278 relevant articles. After eliminating 38 duplicates, we thoroughly analysed the remaining 240 articles by examining their titles and abstracts. Finally, 126 articles were selected for inclusion in this comprehensive study on UD.</div></div><div><h3>Discussion</h3><div>This review explores the plant identifiable characteristics, geographical distribution and taxonomic classification. The phytochemicals found in plants include sterols, fatty acids, alkaloids, terpenoids, flavonoids, lignans, and essential oils, all of which contribute to their medicinal and therapeutic properties. It exhibits a broad range of pharmacological activities including anti-inflammatory, hypoglycaemic, antiurolithiatic, neuroprotective, antioxidant, antimicrobial, antiproliferative, and anticancer effects. UD leaves contain high levels of antioxidants, which may be useful for the treatment of breast cancer by inducing apoptosis. UD extracts <em>exert</em> a protective function by regulating blood glucose levels and β-cell activity, exhibiting insulin-like effects. It also inhibits pro-inflammatory pathways and demonstrates hepatoprotective properties following hepatectomy. UD extract inhibits the proliferation and migration of cancer cells and displays antiviral activity against rotavirus and feline immunodeficiency virus. Furthermore, UD is effective in treating chronic conditions, such as prostatitis, dandruff, and osteoarthritis, thereby reducing the need for conventional medications.</div></div><div><h3>Conclusion</h3><div>The diverse uses and biological properties of UD make it a subject of interest for future research.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100935"},"PeriodicalIF":2.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustained use of antimutagenic bioactives having affinity with DNA minor groove could prevent in vitro neoplastic induction 持续使用与 DNA 小沟亲和的抗突变生物活性物质可防止体外肿瘤诱导

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-11 DOI: 10.1016/j.hermed.2024.100939

Jyoti Tripathi , Surbhi Wadhawan , Sumit Gupta , Satyendra Gautam

Introduction

Studies on the antimutagenic and anti-neoplastic effect of dietary ingredients can be useful in developing nutraceuticals for preventing neoplastic induction. In the current study the query whether food rich in antimutagenic potential equally suppress the neoplastic induction, was addressed, with potential mechanism of action.

Methods

The antimutagenic activity was evaluated using the TK6 gene mutation assay, assessing the reduction in ethyl methanesulfonate (EMS)-induced mutation in presence of vegetable extracts. The anti-⁠neoplastic activity was assessed using the C3H/⁠10T1/⁠2 cell transformation assay, quantifying the inhibition of anchorage-independent growth and type III foci formation. The prominent compounds in the vegetable extract were characterised using gas chromatography-⁠mass spectrometry (GC-⁠MS), and their interactions with DNA were predicted using molecular docking.

Results

Among the vegetable extracts, garlic exhibited the most potent antimutagenic and anti-neoplastic effects, followed by spinach and beans. Garlic extract exhibited significantly high antimutagenic potential (59 ± 3%), and anti-neoplastic activity in the terms of inhibition of anchorage independence (65 ± 3%) and inhibition of type III foci formation (90 ± 5%). GC-MS analysis of garlic extract identified abundant organosulphur compounds, terpenes, and terpenoids. Molecular docking studies suggested that these compounds bind to the DNA minor groove with binding energies ranging from −⁠4.3 to −⁠7.21 kcal mol^-⁠1.

Discussion

The antimutagenic and antineoplastic activities showed a positive correlation (r = 0.92–0.93), where garlic extract showed the highest potential. The DNA binding properties of the prominent compounds in garlic extract suggests a potential mechanism of action involving interference with carcinogen activity and subsequent prevention of gene dysregulation.

导言研究膳食成分的抗突变和抗肿瘤作用有助于开发预防肿瘤诱导的营养保健品。本研究探讨了富含抗突变潜能的食物是否同样能抑制肿瘤诱导的问题，以及潜在的作用机制。抗肿瘤活性采用 C3H/10T1/2 细胞转化试验进行评估，对锚定依赖性生长和 III 型病灶形成的抑制作用进行量化。利用气相色谱-质谱法（GC-MS）对蔬菜提取物中的主要化合物进行了表征，并利用分子对接法预测了它们与 DNA 的相互作用。大蒜提取物具有明显的高抗突变潜能（59 ± 3%），在抑制锚定独立性（65 ± 3%）和抑制 III 型病灶形成（90 ± 5%）方面具有抗肿瘤活性。大蒜提取物的气相色谱-质谱分析鉴定出了丰富的有机硫化合物、萜烯和萜类化合物。分子对接研究表明，这些化合物与 DNA 小沟的结合能为 -4.3 至 -7.21 kcal mol-1。讨论抗突变活性和抗肿瘤活性呈正相关（r = 0.92-0.93），其中大蒜提取物的潜力最大。大蒜提取物中主要化合物的 DNA 结合特性表明，其潜在的作用机制包括干扰致癌物质的活性，进而防止基因失调。

{"title":"Sustained use of antimutagenic bioactives having affinity with DNA minor groove could prevent in vitro neoplastic induction","authors":"Jyoti Tripathi , Surbhi Wadhawan , Sumit Gupta , Satyendra Gautam","doi":"10.1016/j.hermed.2024.100939","DOIUrl":"10.1016/j.hermed.2024.100939","url":null,"abstract":"<div><h3>Introduction</h3><div>Studies on the antimutagenic and anti-neoplastic effect of dietary ingredients can be useful in developing nutraceuticals for preventing neoplastic induction. In the current study the query whether food rich in antimutagenic potential equally suppress the neoplastic induction, was addressed, with potential mechanism of action.</div></div><div><h3>Methods</h3><div>The antimutagenic activity was evaluated using the TK6 gene mutation assay, assessing the reduction in ethyl methanesulfonate (EMS)-induced mutation in presence of vegetable extracts. The anti-⁠neoplastic activity was assessed using the C3H/⁠10T1/⁠2 cell transformation assay, quantifying the inhibition of anchorage-independent growth and type III foci formation. The prominent compounds in the vegetable extract were characterised using gas chromatography-⁠mass spectrometry (GC-⁠MS), and their interactions with DNA were predicted using molecular docking.</div></div><div><h3>Results</h3><div>Among the vegetable extracts, garlic exhibited the most potent antimutagenic and anti-neoplastic effects, followed by spinach and beans. Garlic extract exhibited significantly high antimutagenic potential (59±3%), and anti-neoplastic activity in the terms of inhibition of anchorage independence (65±3%) and inhibition of type III foci formation (90±5%). GC-MS analysis of garlic extract identified abundant organosulphur compounds, terpenes, and terpenoids. Molecular docking studies suggested that these compounds bind to the DNA minor groove with binding energies ranging from −⁠4.3 to −⁠7.21 kcal mol<sup>-⁠1</sup>.</div></div><div><h3>Discussion</h3><div>The antimutagenic and antineoplastic activities showed a positive correlation (<em>r</em>  <!-->0.92–0.93), where garlic extract showed the highest potential. The DNA binding properties of the prominent compounds in garlic extract suggests a potential mechanism of action involving interference with carcinogen activity and subsequent prevention of gene dysregulation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100939"},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combating paediatric pneumonia: the dynamic duo of cinnamon-clove steam and physiotherapy 防治小儿肺炎：肉桂丁香蒸汽和物理疗法的活力组合

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-11 DOI: 10.1016/j.hermed.2024.100938

Arslan Iftikhar, Mehlaqa Waseem, Haseeb Anwar

Introduction

Paediatric community-acquired pneumonia (CAP) is a prevailing respiratory infection that impacts children in non-medical settings, giving rise to substantial morbidity and mortality, especially in less developed areas. The current study was aimed at finding a holistic approach for improving the management and treatment of paediatric CAP. For that purpose, a comparative interventional study was conducted to investigate the effectiveness of chest physiotherapy (CPT) combining with Cinnamon varum and Syzygium aromaticum steam therapy in paediatric CAP.

Methods

A total of 60 paediatric patient hospitalised with CAP were assessed. The study included both male and female participants aged between three and 14 years. The study was conducted at Children Hospital and Institute of Child Health in Faisalabad, Pakistan. The subjects were divided into three equal groups: group 1 received CPT, group 2 underwent CPT accompanied with nebulization, and group 3 received CPT along with steam therapy using C. varum and S. aromaticum. Each participant received the assigned therapy twice a day for seven consecutive days. The study was approved and registered by Ethics Review Committee, Government College University, Faisalabad, Pakistan (Reference number GCUF/ERC/214).

Results

Among the three groups studied, those who received the combined therapy exhibited improved outcome by improving the complete blood count (CBC), spirometer index, arterial blood gases (ABGs) and Systolic blood pressure, Multilobar infiltrates, Albumin, Respiratory rate, Tachycardia, Confusion, Oxygen and pH severity score for pneumonia.

Conclusions

The antimicrobial, anti-inflammatory and mucolytic properties of cinnamon and clove, along with the positive effects of CPT, resulted in reduced lung inflammation, enhanced respiratory performance, and improved vital signs.

导言小儿社区获得性肺炎（CAP）是一种普遍存在的呼吸道感染，影响着非医疗环境中的儿童，导致大量的发病率和死亡率，尤其是在欠发达地区。本研究旨在寻找一种全面的方法来改善儿科 CAP 的管理和治疗。为此，本研究进行了一项比较性干预研究，以探讨胸部物理疗法（CPT）与肉桂蒸气疗法和芳香茜草蒸气疗法相结合对儿科 CAP 的疗效。研究对象包括 3 至 14 岁的男性和女性。研究在巴基斯坦费萨拉巴德的儿童医院和儿童健康研究所进行。受试者被平均分为三组：第一组接受 CPT，第二组在接受 CPT 的同时进行雾化治疗，第三组在接受 CPT 的同时使用香附子和芳香草进行蒸汽治疗。每位受试者每天接受两次指定疗法，连续七天。结果在所研究的三组患者中，接受联合疗法的患者的治疗效果有所改善，全血细胞计数（CBC）、肺活量指数、动脉血气（ABGs）和收缩压、多叶浸润、白蛋白、呼吸频率、心动过速、意识模糊、氧气和肺炎的 pH 值都有所改善。结论肉桂和丁香的抗菌、抗炎和粘液溶解特性以及 CPT 的积极作用可减轻肺部炎症，增强呼吸功能，改善生命体征。

{"title":"Combating paediatric pneumonia: the dynamic duo of cinnamon-clove steam and physiotherapy","authors":"Arslan Iftikhar, Mehlaqa Waseem, Haseeb Anwar","doi":"10.1016/j.hermed.2024.100938","DOIUrl":"10.1016/j.hermed.2024.100938","url":null,"abstract":"<div><h3>Introduction</h3><div>Paediatric community-acquired pneumonia (CAP) is a prevailing respiratory infection that impacts children in non-medical settings, giving rise to substantial morbidity and mortality, especially in less developed areas. The current study was aimed at finding a holistic approach for improving the management and treatment of paediatric CAP. For that purpose, a comparative interventional study was conducted to investigate the effectiveness of chest physiotherapy (CPT) combining with <em>Cinnamon varum</em> and <em>Syzygium aromaticum</em> steam therapy in paediatric CAP.</div></div><div><h3>Methods</h3><div>A total of 60 paediatric patient hospitalised with CAP were assessed. The study included both male and female participants aged between three and 14 years. The study was conducted at Children Hospital and Institute of Child Health in Faisalabad, Pakistan. The subjects were divided into three equal groups: group 1 received CPT, group 2 underwent CPT accompanied with nebulization, and group 3 received CPT along with steam therapy using <em>C. varum</em> and <em>S. aromaticum</em>. Each participant received the assigned therapy twice a day for seven consecutive days. The study was approved and registered by Ethics Review Committee, Government College University, Faisalabad, Pakistan (Reference number GCUF/ERC/214).</div></div><div><h3>Results</h3><div>Among the three groups studied, those who received the combined therapy exhibited improved outcome by improving the complete blood count (CBC), spirometer index, arterial blood gases (ABGs) and Systolic blood pressure, Multilobar infiltrates, Albumin, Respiratory rate, Tachycardia, Confusion, Oxygen and pH severity score for pneumonia.</div></div><div><h3>Conclusions</h3><div>The antimicrobial, anti-inflammatory and mucolytic properties of cinnamon and clove, along with the positive effects of CPT, resulted in reduced lung inflammation, enhanced respiratory performance, and improved vital signs.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100938"},"PeriodicalIF":2.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Human Papilloma Virus-Related Cervical and Gynaecological Pathogenesis Using Herbal Medicine, Meta Analysis 利用中草药治疗人乳头瘤病毒相关宫颈和妇科疾病的发病机制，Meta 分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-03 DOI: 10.1016/j.hermed.2024.100933

L. Qiao , X. Fan , Y. Xiao , J. Liang

Introduction

Human papillomavirus (HPV) is a major cause of cervical cancer, particularly types 16 and 18, which are responsible for 70% of cases. The current study’s main aim is to evaluate the impact of using herbal medicine extract for the management of HPV-related cervical and gynaecological pathogenesis.

Methods

A systematic literature was accomplished and 2007 patients with HPV-related diseases were recruited to the current studies; 1 089 of them were treated with herbal extracted products, and 918 were control groups. The inclusion criteria of the current study recruited only randomised clinical trials with a comparison-based design.

Results

Using herbal extracts for the treatment of HPV-related pathogenesis showed a significant improvement in short- and long-term using several plant-based preparations. Improved parameters were the rate of HPV clearance (P < 0.001), rate of cervical intraepithelial neoplasia (P < 0.001), and adverse events (P > 0.05). In contrast to the significant difference between the intervention group and control regarding efficacy-related parameters, there were no significant differences regarding adverse events occurrence rate. The heterogeneity of different model levels was assessed by I² and ranged from 0% to 86.6%.

Conclusions

Using herbal medicine for the management of HPV-related cervical pathogenesis showed a beneficial impact regarding the clearance rate of high-risk HPV and a higher rate of cervical intraepithelial neoplasia regression. In addition, herbal medicines showed high safety rates compared to control.

导言人类乳头瘤病毒（HPV）是宫颈癌的主要病因，尤其是16型和18型，占70%。本研究的主要目的是评估使用中草药提取物治疗与 HPV 相关的宫颈癌和妇科疾病发病机制的影响。方法通过系统性文献研究，本研究招募了 2007 名患有 HPV 相关疾病的患者，其中 1 089 人接受了中草药提取物治疗，918 人为对照组。本研究的纳入标准仅包括基于比较设计的随机临床试验。结果使用草药提取物治疗人乳头瘤病毒相关疾病的发病机制显示，使用几种植物制剂在短期和长期治疗中均有显著改善。改善的参数包括 HPV 清除率（P< 0.001）、宫颈上皮内瘤变率（P< 0.001）和不良反应（P> 0.05）。干预组与对照组在疗效相关参数方面存在显著差异，而在不良事件发生率方面则无显著差异。结论使用中药治疗与HPV相关的宫颈发病机制，对高危HPV的清除率和更高的宫颈上皮内瘤变消退率产生了有益的影响。此外，与对照组相比，中药显示出较高的安全性。

{"title":"Management of Human Papilloma Virus-Related Cervical and Gynaecological Pathogenesis Using Herbal Medicine, Meta Analysis","authors":"L. Qiao , X. Fan , Y. Xiao , J. Liang","doi":"10.1016/j.hermed.2024.100933","DOIUrl":"10.1016/j.hermed.2024.100933","url":null,"abstract":"<div><h3>Introduction</h3><p>Human papillomavirus (<strong>HPV</strong>) is a major cause of cervical cancer, particularly types 16 and 18, which are responsible for 70% of cases. The current study’s main aim is to evaluate the impact of using herbal medicine extract for the management of HPV-related cervical and gynaecological pathogenesis.</p></div><div><h3>Methods</h3><p>A systematic literature was accomplished and 2007 patients with HPV-related diseases were recruited to the current studies; 1 089 of them were treated with herbal extracted products, and 918 were control groups. The inclusion criteria of the current study recruited only randomised clinical trials with a comparison-based design.</p></div><div><h3>Results</h3><p>Using herbal extracts for the treatment of HPV-related pathogenesis showed a significant improvement in short- and long-term using several plant-based preparations. Improved parameters were the rate of HPV clearance (<em>P</em> < 0.001), rate of cervical intraepithelial neoplasia (<em>P</em> < 0.001), and adverse events (<em>P</em> > 0.05). In contrast to the significant difference between the intervention group and control regarding efficacy-related parameters, there were no significant differences regarding adverse events occurrence rate<strong>.</strong> The heterogeneity of different model levels was assessed by I<sup>2</sup> and ranged from 0% to 86.6%.</p></div><div><h3>Conclusions</h3><p>Using herbal medicine for the management of HPV-related cervical pathogenesis showed a beneficial impact regarding the clearance rate of high-risk HPV and a higher rate of cervical intraepithelial neoplasia regression. In addition, herbal medicines showed high safety rates compared to control.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100933"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Mechanism of Wenhua Decoction in the Treatment of Non–Small Cell Lung Cancer by Network Pharmacology and Molecular Dynamics Simulation 通过网络药理学和分子动力学模拟研究温化水煎剂治疗非小细胞肺癌的机制

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-03 DOI: 10.1016/j.hermed.2024.100934

D. Wei

Introduction

Network pharmacology approaches were applied to reveal the mechanism of Wenhua Decoction in non–small cell lung cancer (NSCLC) treatment.

Methods

Effective chemical constituents and targets of Wenhua Decoction were collected by database, and differentially expressed genes of NSCLC were screened. Restart random walk analysis for protein-protein interaction network was conducted using the intersected genes of differentially expressed genes and target genes in NSCLC as seeds. The top 50 genes in affinity coefficient were used to construct the drug-active constituent-gene interaction network. Molecular docking and molecular dynamic analyses were conducted for core targets and corresponding active constituents in the network. Quercetin content was determined by HPLC. Quantitative real time polymerase chain reaction (qRT-PCR) was performed to assess CDK1 expression in A549 cells. The effects of Wenhua Decoction on the cell cycle were evaluated in sh-CDK1 cells. Cellular thermal shift assay was utilised to examine the binding status between CDK1 and its target quercetin.

Results

The drug-active constituent-gene interaction network demonstrated that CDK1 was at the core of the network. Quercetin could bind to CDK1 stably while causing no significant changes in protein conformation. Wenhua Decoction treatment significantly reduced CDK1 expression and blocked transition of cancer cells from the G1 to the S phase. The quercetin content was 16.0 μg/g. Furthermore, cellular thermal shift assay experiment showed a high binding affinity between CDK1 and quercetin present in the Wenhua Decoction.

Conclusions

This study revealed potential targets, active constituents, and mechanism of Wenhua Decoction in treating NSCLC, providing a reference for clinical treatment of NSCLC with Wenhua Decoction.

方法通过数据库收集文华煎剂的有效化学成分和靶点，筛选NSCLC的差异表达基因。以NSCLC差异表达基因和靶基因的交叉基因为种子，重新开始随机游走分析蛋白-蛋白相互作用网络。亲和力系数排名前50的基因被用于构建药物活性成分-基因相互作用网络。对网络中的核心靶点和相应的活性成分进行分子对接和分子动力学分析。槲皮素含量通过高效液相色谱法测定。定量实时聚合酶链反应（qRT-PCR）评估了CDK1在A549细胞中的表达。在 sh-CDK1 细胞中评估了文花煎对细胞周期的影响。结果药物活性成分-基因相互作用网络显示，CDK1是该网络的核心。槲皮素能与CDK1稳定结合，但不会引起蛋白质构象的显著变化。文华煎剂能明显降低 CDK1 的表达，阻止癌细胞从 G1 期向 S 期转化。槲皮素含量为 16.0 μg/g。结论本研究揭示了文华水煎液治疗NSCLC的潜在靶点、活性成分和作用机制，为文华水煎液治疗NSCLC的临床应用提供了参考。

{"title":"The Mechanism of Wenhua Decoction in the Treatment of Non–Small Cell Lung Cancer by Network Pharmacology and Molecular Dynamics Simulation","authors":"D. Wei","doi":"10.1016/j.hermed.2024.100934","DOIUrl":"10.1016/j.hermed.2024.100934","url":null,"abstract":"<div><h3>Introduction</h3><div>Network pharmacology approaches were applied to reveal the mechanism of Wenhua Decoction in non–small cell lung cancer (<strong>NSCLC</strong>) treatment.</div></div><div><h3>Methods</h3><div>Effective chemical constituents and targets of Wenhua Decoction were collected by database, and differentially expressed genes of NSCLC were screened. Restart random walk analysis for protein-protein interaction network was conducted using the intersected genes of differentially expressed genes and target genes in NSCLC as seeds. The top 50 genes in affinity coefficient were used to construct the drug-active constituent-gene interaction network. Molecular docking and molecular dynamic analyses were conducted for core targets and corresponding active constituents in the network. Quercetin content was determined by HPLC. Quantitative real time polymerase chain reaction (qRT-PCR) was performed to assess CDK1 expression in A549 cells. The effects of Wenhua Decoction on the cell cycle were evaluated in sh-CDK1 cells. Cellular thermal shift assay was utilised to examine the binding status between CDK1 and its target quercetin.</div></div><div><h3>Results</h3><div>The drug-active constituent-gene interaction network demonstrated that CDK1 was at the core of the network. Quercetin could bind to CDK1 stably while causing no significant changes in protein conformation. Wenhua Decoction treatment significantly reduced CDK1 expression and blocked transition of cancer cells from the G1 to the S phase. The quercetin content was 16.0 μg/g. Furthermore, cellular thermal shift assay experiment showed a high binding affinity between CDK1 and quercetin present in the Wenhua Decoction.</div></div><div><h3>Conclusions</h3><div>This study revealed potential targets, active constituents, and mechanism of Wenhua Decoction in treating NSCLC, providing a reference for clinical treatment of NSCLC with Wenhua Decoction.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100934"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the immunomodulatory effects of polysaccharides in the management of inflammatory bowel disease: a review 探讨多糖在治疗炎症性肠病中的免疫调节作用：综述

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-03 DOI: 10.1016/j.hermed.2024.100932

Madhu Bala Durairajan, Parimelazhagan Thangaraj

Introduction

This study highlights the diverse roles of polysaccharides in health, focusing on their potential applications in inflammatory bowel disease. Polysaccharides are complex biopolymers consisting of bonded monosaccharides that possess branching or linear forms.

Objective

As potential natural antioxidants and diabetes ameliorators, the study aimed on exploring the therapeutic applications of polysaccharides, particularly focusing its role in the treatment of inflammatory bowel disease.

Sources of evidence

Electronic bibliographic databases like PUBMED and Google Scholar were used to find relevant peer-reviewed studies in English from 2008 to 2024. Finally, 51 studies were included in the analysis.

Results

In inflammatory bowel disease, which is marked by mucosal inflammation and gut microbial dysbiosis, the interaction of genetics, environment, and gut microbiota highlights the significance of comprehending and treating dysbiosis for mucosal immunological health. Through their modulation of intestinal flora, the immune system, and inflammatory cytokines, polysaccharides significantly impact ulcerative colitis and Crohn’s disease. The intricate involvement of Toll-like receptors and downstream signalling pathways, including MAPK, GPCR, JAK-STAT and NF-κB, presents therapeutic opportunities for mitigating IBD complexities and restoring immune homoeostasis.

Conclusion

Polysaccharides demonstrate multifaceted benefits including anti-inflammatory, antioxidative, and immunomodulatory effects. By regulating cytokine signalling and supporting gut health, polysaccharides present promising avenues for developing therapeutics targeting inflammatory conditions, particularly inflammatory bowel diseases.

引言本研究强调了多糖在健康方面的多种作用，重点是多糖在炎症性肠病中的潜在应用。多糖是一种复杂的生物聚合物，由具有分支或线性形式的键合单糖组成。作为潜在的天然抗氧化剂和糖尿病改善剂，本研究旨在探索多糖的治疗应用，尤其关注其在治疗炎症性肠病方面的作用。结果在以粘膜炎症和肠道微生物菌群失调为特征的炎症性肠病中，遗传、环境和肠道微生物菌群的相互作用凸显了理解和治疗菌群失调对粘膜免疫健康的重要意义。多糖通过调节肠道菌群、免疫系统和炎症细胞因子，对溃疡性结肠炎和克罗恩病产生重大影响。Toll 样受体和下游信号通路（包括 MAPK、GPCR、JAK-STAT 和 NF-κB）的复杂参与为减轻 IBD 的复杂性和恢复免疫平衡提供了治疗机会。通过调节细胞因子信号和支持肠道健康，多糖为开发针对炎症（尤其是炎症性肠病）的疗法提供了前景广阔的途径。

{"title":"Exploring the immunomodulatory effects of polysaccharides in the management of inflammatory bowel disease: a review","authors":"Madhu Bala Durairajan, Parimelazhagan Thangaraj","doi":"10.1016/j.hermed.2024.100932","DOIUrl":"10.1016/j.hermed.2024.100932","url":null,"abstract":"<div><h3>Introduction</h3><p>This study highlights the diverse roles of polysaccharides in health, focusing on their potential applications in inflammatory bowel disease. Polysaccharides are complex biopolymers consisting of bonded monosaccharides that possess branching or linear forms.</p></div><div><h3>Objective</h3><p>As potential natural antioxidants and diabetes ameliorators, the study aimed on exploring the therapeutic applications of polysaccharides, particularly focusing its role in the treatment of inflammatory bowel disease.</p></div><div><h3>Sources of evidence</h3><p>Electronic bibliographic databases like PUBMED and Google Scholar were used to find relevant peer-reviewed studies in English from 2008 to 2024. Finally, 51 studies were included in the analysis.</p></div><div><h3>Results</h3><p>In inflammatory bowel disease, which is marked by mucosal inflammation and gut microbial dysbiosis, the interaction of genetics, environment, and gut microbiota highlights the significance of comprehending and treating dysbiosis for mucosal immunological health. Through their modulation of intestinal flora, the immune system, and inflammatory cytokines, polysaccharides significantly impact ulcerative colitis and Crohn’s disease. The intricate involvement of Toll-like receptors and downstream signalling pathways, including MAPK, GPCR, JAK-STAT and NF-κB, presents therapeutic opportunities for mitigating IBD complexities and restoring immune homoeostasis.</p></div><div><h3>Conclusion</h3><p>Polysaccharides demonstrate multifaceted benefits including anti-inflammatory, antioxidative, and immunomodulatory effects. By regulating cytokine signalling and supporting gut health, polysaccharides present promising avenues for developing therapeutics targeting inflammatory conditions, particularly inflammatory bowel diseases.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100932"},"PeriodicalIF":2.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential use of plant-based therapeutics for the management of SARS-COV2 infection in diabetes mellitus – a review 利用植物疗法治疗糖尿病患者 SARS-COV2 感染的可能性综述

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.hermed.2024.100923

Neha Deora , Krishnan Venkatraman

Introduction

The COVID-19 pandemic observed during 2019–2021 challenged healthcare systems, making the infection a global public health emergency. Diabetes emerged rapidly as a major comorbidity for COVID-19 severity, increasing the risk of negative outcomes in diabetics if infected with COVID-19. The pandemic has prompted extensive research into potential therapies, including the investigation of natural products as repurposing drugs. They have unrivalled benefits, including a wealth of experience, diverse biological activity, and unique diversity.

Objective

This updated review aims to emphasise on some of the plants and their metabolites that are known to offer therapeutic benefits against diabetes mellitus towards increased inflammation, blood coagulation and vascular complications and can be used as potential adjuvant therapy in diabetics with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods

The reported literature was sourced from PubMed, Science Direct, Google Scholar, Web of Science, Scopus, Clinical Trials.gov, and Wiley online library with a focus on peer-reviewed English-language publications that exclusively addressed type 2 diabetes and COVID-19 interaction, clinical implications, and the anti-diabetic effects of natural products and traditional medicine.

Conclusion

The anti-inflammatory, immunomodulatory, anticoagulant and endothelial nitric oxide synthase (eNOS) modulating potential of several of these plants laid down a strong rationale for their use in developing therapies against SARS-CoV-2 infection, and may represent a beneficial contributory step in the management of COVID-19 in diabetics.

导言2019-2021年期间观察到的COVID-19大流行对医疗保健系统提出了挑战，使该感染成为全球公共卫生紧急事件。糖尿病迅速成为 COVID-19 严重程度的主要合并症，增加了糖尿病患者感染 COVID-19 后出现不良后果的风险。这一流行病促使人们对潜在疗法进行广泛研究，包括将天然产品作为再利用药物进行研究。本最新综述旨在强调一些植物及其代谢物对糖尿病患者的炎症加重、血液凝固和血管并发症有治疗作用，并可用作严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）感染糖尿病患者的潜在辅助疗法。方法所报道的文献来自 PubMed、Science Direct、Google Scholar、Web of Science、Scopus、Clinical Trials.gov 和 Wiley 在线图书馆，重点是经同行评审、专门论述 2 型糖尿病与 COVID-19 的相互作用、临床意义以及天然产品和传统药物的抗糖尿病作用的英文出版物。结论其中几种植物具有抗炎、免疫调节、抗凝血和调节血管内皮一氧化氮合酶（eNOS）的潜力，这为将它们用于开发抗 SARS-CoV-2 感染的疗法提供了强有力的依据，并可能为糖尿病患者治疗 COVID-19 迈出有益的一步。

{"title":"Potential use of plant-based therapeutics for the management of SARS-COV2 infection in diabetes mellitus – a review","authors":"Neha Deora , Krishnan Venkatraman","doi":"10.1016/j.hermed.2024.100923","DOIUrl":"10.1016/j.hermed.2024.100923","url":null,"abstract":"<div><h3>Introduction</h3><p>The COVID-19 pandemic observed during 2019–2021 challenged healthcare systems, making the infection a global public health emergency. Diabetes emerged rapidly as a major comorbidity for COVID-19 severity, increasing the risk of negative outcomes in diabetics if infected with COVID-19. The pandemic has prompted extensive research into potential therapies, including the investigation of natural products as repurposing drugs. They have unrivalled benefits, including a wealth of experience, diverse biological activity, and unique diversity.</p></div><div><h3>Objective</h3><p>This updated review aims to emphasise on some of the plants and their metabolites that are known to offer therapeutic benefits against diabetes mellitus towards increased inflammation, blood coagulation and vascular complications and can be used as potential adjuvant therapy in diabetics with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.</p></div><div><h3><strong>Methods</strong></h3><p>The reported literature was sourced from PubMed, Science Direct, Google Scholar, Web of Science, Scopus, Clinical Trials.gov, and Wiley online library with a focus on peer-reviewed English-language publications that exclusively addressed type 2 diabetes and COVID-19 interaction, clinical implications, and the anti-diabetic effects of natural products and traditional medicine.</p></div><div><h3>Conclusion</h3><p>The anti-inflammatory, immunomodulatory, anticoagulant and endothelial nitric oxide synthase (eNOS) modulating potential of several of these plants laid down a strong rationale for their use in developing therapies against SARS-CoV-2 infection, and may represent a beneficial contributory step in the management of COVID-19 in diabetics.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"47 ","pages":"Article 100923"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Activity and Phytochemistry of Psidium guajava Essential Oil From Palestine: Targeting Oral Microbial Strains 巴勒斯坦番石榴精油的抗菌活性和植物化学：针对口腔微生物菌株

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.hermed.2024.100928

M. Qadi , N. Jaradat , N. Al-Maharik , M. Abdalrazeq , N. Massad , S. Rabaya , M. Batanjeh , H. Tomeh

Introduction

The prevalence of oral diseases has been rising, presenting a significant challenge exacerbated by the increasing resistance of bacteria due to the inappropriate use of antibiotics. Given the typical financial challenges encountered in developing nations, there is an urgent requirement for alternative approaches and materials to address and manage these diseases. This study aims to investigate the chemical composition and antimicrobial properties of Psidium guajava leaf essential oil (PGL-EO) against specific oral bacterial species.

Methods

The extraction of PGL-EO was conducted using a Clevenger apparatus, and the chemical composition of PGL-EO was determined using gas chromatography-mass spectrometry (GC-MS) analysis. Various microbial strains from the American Type Culture Collection (ATCC) and clinically obtained oral strains were selected, and the antibacterial activity was assessed using the microdilution broth technique.

Results

The GC-MS analysis indicated the existence of 28 chemicals in PGL-EO, representing 97.76% of the total oil composition. The primary constituents found in this material consisted of l-limonene (31.70%), caryophyllene (27.31%), and caryophyllene oxide (6.90%). In addition, the major phytochemical class was sesquiterpene hydrocarbons (42.35%), followed by monoterpene hydrocarbons (32.30%) and oxygenated sesquiterpenoids (21.51%). PGL-EO exhibited remarkable antimicrobial efficacy against Streptococcus mutans, Streptococcus mitis, Streptococcus sanguinis, Enterococcus faecalis, Lactobacillus acidophilus, and Candida albicans..

Conclusions

The findings of this study strongly suggest that PGL-EO holds potential as an effective anti-plaque and anticary agent. Furthermore, the results obtained in this study consider PGL-EO a promising anticandidal agent in that it can contribute to treating and preventing oral diseases.

导言口腔疾病的发病率一直在上升，由于抗生素的不当使用，细菌的抗药性不断增强，这加剧了口腔疾病的严重性。鉴于发展中国家面临的典型财政挑战，迫切需要替代方法和材料来应对和管理这些疾病。本研究旨在调查番石榴叶精油（PGL-EO）的化学成分和对特定口腔细菌种类的抗菌特性。方法使用 Clevenger 仪器提取 PGL-EO，并使用气相色谱-质谱分析法（GC-MS）测定 PGL-EO 的化学成分。结果气相色谱-质谱分析表明，PGL-EO 中含有 28 种化学物质，占油总成分的 97.76%。其中的主要成分包括柠檬烯（31.70%）、叶黄素（27.31%）和氧化叶黄素（6.90%）。此外，主要的植物化学成分是倍半萜碳氢化合物（42.35%），其次是单萜碳氢化合物（32.30%）和含氧倍半萜类化合物（21.51%）。PGL-EO 对变异链球菌、肝炎链球菌、血链球菌、粪肠球菌、嗜酸乳杆菌和白色念珠菌具有显著的抗菌效果。此外，本研究的结果还认为 PGL-EO 是一种很有前途的抗念珠菌剂，有助于治疗和预防口腔疾病。

{"title":"Antimicrobial Activity and Phytochemistry of Psidium guajava Essential Oil From Palestine: Targeting Oral Microbial Strains","authors":"M. Qadi , N. Jaradat , N. Al-Maharik , M. Abdalrazeq , N. Massad , S. Rabaya , M. Batanjeh , H. Tomeh","doi":"10.1016/j.hermed.2024.100928","DOIUrl":"10.1016/j.hermed.2024.100928","url":null,"abstract":"<div><h3>Introduction</h3><p>The prevalence of oral diseases has been rising, presenting a significant challenge exacerbated by the increasing resistance of bacteria due to the inappropriate use of antibiotics. Given the typical financial challenges encountered in developing nations, there is an urgent requirement for alternative approaches and materials to address and manage these diseases. This study aims to investigate the chemical composition and antimicrobial properties of <em>Psidium guajava</em> leaf essential oil (PGL-EO) against specific oral bacterial species.</p></div><div><h3>Methods</h3><p>The extraction of PGL-EO was conducted using a Clevenger apparatus, and the chemical composition of PGL-EO was determined using gas chromatography-mass spectrometry (GC-MS) analysis. Various microbial strains from the American Type Culture Collection (ATCC) and clinically obtained oral strains were selected, and the antibacterial activity was assessed using the microdilution broth technique.</p></div><div><h3>Results</h3><p>The GC-MS analysis indicated the existence of 28 chemicals in PGL-EO, representing 97.76% of the total oil composition. The primary constituents found in this material consisted of l-limonene (31.70%), caryophyllene (27.31%), and caryophyllene oxide (6.90%). In addition, the major phytochemical class was sesquiterpene hydrocarbons (42.35%), followed by monoterpene hydrocarbons (32.30%) and oxygenated sesquiterpenoids (21.51%). PGL-EO exhibited remarkable antimicrobial efficacy against <em>Streptococcus mutans</em>, <em>Streptococcus mitis, Streptococcus sanguinis</em>, <em>Enterococcus faecalis, Lactobacillus acidophilus, and Candida albicans..</em></p></div><div><h3>Conclusions</h3><p>The findings of this study strongly suggest that PGL-EO holds potential as an effective anti-plaque and anticary agent. Furthermore, the results obtained in this study consider PGL-EO a promising anticandidal agent in that it can contribute to treating and preventing oral diseases.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"47 ","pages":"Article 100928"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

South African medicinal plants used for health conditions affecting males: an ethnobotanical review 南非用于治疗男性健康问题的药用植物：人种植物学综述

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.hermed.2024.100931

Mompati V. Chakale , Makhotso Lekhooa , Adeyemi O. Aremu

Introduction

Health issues affecting males remain a public health challenge due to the limited treatments and male health-seeking behaviour. In South Africa, local communities have relied on plant-based therapies to address health issues including those affecting males. This review explored the ethnobotanical and indigenous knowledge of plants used for managing male urogenital and sexual-reproductive conditions in South Africa, to establish the existing status and identify gaps for further research.

Methods

Following a systematic search, 51 eligible studies were extracted from electronic databases.

Results

A total of 337 plants belonging to 83 families were collated across seven provinces in South Africa. Fabaceae (37) and Asteraceae (37) were the most represented plant families. Hypoxis hemerocallidea Fisch., C.A.Mey. & Avé-Lall. (18 citations), and Entada elephantina (Burch.) S.A.O’Donnell & G.P.Lewis (synonym: Elephantorrhiza elephantina (Burch.) Skeels) (12 citations) were the commonly used plants. Roots (33.4%) and leaves (17%) were the most commonly used plant parts. Decoction (44%) and oral-based (53%) were the dominant preparation and administration method, respectively. The two major health conditions had 18 sub-categories as derived from the eligible studies. Particularly, aphrodisiac and erectile dysfunction were the most encountered conditions and were managed with 133 plants. Provinces such as the Northern Cape and North West had limited studies on plants used for male healthcare needs.

Conclusion

We highlighted the importance of plants in meeting the primary healthcare needs of males. This suggests the need to promote additional research into the cultural, therapeutic, and dynamic trends in the use of plants for meeting the healthcare needs of males, especially in rural areas.

导言：由于治疗方法有限和男性寻求健康的行为，影响男性的健康问题仍然是一项公共卫生挑战。在南非，当地社区依靠植物疗法来解决健康问题，包括影响男性的健康问题。本综述探讨了南非用于治疗男性泌尿生殖和性生殖疾病的植物的人种植物学和本土知识，以确定现有状况并找出有待进一步研究的差距。其中最多的植物科是豆科（37 种）和菊科（37 种）。Hypoxis hemerocallidea Fisch.(18次引用）和 Entada elephantina (Burch.) S.A.O'Donnell & G.P.Lewis （异名：Elephantorrhiza elephantina (Burch.) Skeels）（12次引用）是常用植物。根（33.4%）和叶（17%）是最常用的植物部分。煎煮（44%）和口服（53%）分别是最主要的制剂和给药方法。根据符合条件的研究，这两种主要的健康状况共有 18 个子类别。其中，壮阳药和勃起功能障碍是最常见的病症，共使用了 133 种植物进行治疗。结论我们强调了植物在满足男性初级保健需求方面的重要性。这表明有必要推动更多的研究，以了解使用植物满足男性保健需求的文化、治疗和动态趋势，尤其是在农村地区。

{"title":"South African medicinal plants used for health conditions affecting males: an ethnobotanical review","authors":"Mompati V. Chakale , Makhotso Lekhooa , Adeyemi O. Aremu","doi":"10.1016/j.hermed.2024.100931","DOIUrl":"10.1016/j.hermed.2024.100931","url":null,"abstract":"<div><h3>Introduction</h3><p>Health issues affecting males remain a public health challenge due to the limited treatments and male health-seeking behaviour. In South Africa, local communities have relied on plant-based therapies to address health issues including those affecting males. This review explored the ethnobotanical and indigenous knowledge of plants used for managing male urogenital and sexual-reproductive conditions in South Africa, to establish the existing status and identify gaps for further research.</p></div><div><h3>Methods</h3><p>Following a systematic search, 51 eligible studies were extracted from electronic databases.</p></div><div><h3>Results</h3><p>A total of 337 plants belonging to 83 families were collated across seven provinces in South Africa. Fabaceae (37) and Asteraceae (37) were the most represented plant families. <em>Hypoxis hemerocallidea</em> Fisch., C.A.Mey. & Avé-Lall. (18 citations), and <em>Entada elephantina</em> (Burch.) S.A.O’Donnell & G.P.Lewis (synonym: <em>Elephantorrhiza elephantina</em> (Burch.) Skeels) (12 citations) were the commonly used plants. Roots (33.4%) and leaves (17%) were the most commonly used plant parts. Decoction (44%) and oral-based (53%) were the dominant preparation and administration method, respectively. The two major health conditions had 18 sub-categories as derived from the eligible studies. Particularly, aphrodisiac and erectile dysfunction were the most encountered conditions and were managed with 133 plants. Provinces such as the Northern Cape and North West had limited studies on plants used for male healthcare needs.</p></div><div><h3>Conclusion</h3><p>We highlighted the importance of plants in meeting the primary healthcare needs of males. This suggests the need to promote additional research into the cultural, therapeutic, and dynamic trends in the use of plants for meeting the healthcare needs of males, especially in rural areas.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"47 ","pages":"Article 100931"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2210803324000885/pdfft?md5=821655e148a4e1cff4539cedf42777a1&pid=1-s2.0-S2210803324000885-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0