Journal of Herbal Medicine最新文献_第6页

A review article on the antimicrobial and antioxidant essential oils of aromatic plants in Ethiopia 关于埃塞俄比亚芳香植物抗菌和抗氧化精油的综述文章

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-26 DOI: 10.1016/j.hermed.2024.100948

Destaw Damtie

Introduction

Ethiopia has eight vegetation types across altitudes (< 400 - 4533 m). Consequently, it is biologically rich (> 6500–7000 plant species) with 12–19% endemicity. While medicinal plant knowledge in Ethiopia is partially documented, much remains unexplored. This study reviews the essential oils (EOs) of aromatic plants in Ethiopia, known for their antimicrobial and antioxidant properties.

Methods

From November to December 2022, we retrieved 28 studies from PubMed/Medline, Science Direct, SciVerse, Web of Science, and Google Scholar using boolean operators and terms such as ‘essential oil,’ ‘biological activities,’ ‘bioactivy,’ ‘antioxidant activities,’ ‘antibacterial activities,’ ‘antifungal activities,’ ‘antimicrobial activities,’ and ‘Ethiopia.’

Results

Promising antibacterial EOs include Mentha aquatica, Apium leptophyllum, Citrus reticulata, Mentha arvensis, Mentha longifolia, Mentha piperita, Mentha spicata, Olea europaea, Otostegia integrifolia, Phytolacca dodecandra, Plectranthus marrubatus, Salvia nilotica, Salvia officinalis, and Salvia schimperi (MICs < 0.005 to 0.064 mg/mL). For antifungal activity, notable EOs include Acokanthera schimperi, Cinnamomum zeylanicum, C. reticulata, C. reticulata, O. europaea, O. integrifolia, P. dodecandra, P. marrubatus, Satureja paradoxa, and Thymus schimperi (MICs < 1 mg/mL). Antioxidant essential oils were those of Artemisia absinthium L., Artemisia abyssinica, Artemisia afra, Coriandrum sativum, Curcuma domestica, Juniperus procera, Lippia adoensis, Ocimum basilicum, O. europaea, Rosmarinus officinalis, S. officinalis, Satureja abyssinica, and S. paradoxa. The IC₅₀ of all these essential oils was < 0.05 mg/mL.

Conclusion

The present review identified the EOs of many Ethiopian aromatic plants with promising antimicrobial and antioxidant activities that demand more enquiry for preclinical testing, and eventually, clinical applications.

导言埃塞俄比亚有八种植被类型，分布在海拔（400 - 4533 米）不同的地区。因此，埃塞俄比亚拥有丰富的生物资源（6500-7000 种植物），12%-19% 为地方特有物种。虽然埃塞俄比亚的药用植物知识已有部分记载，但仍有许多尚未开发。本研究综述了埃塞俄比亚芳香植物的精油（EOs），这些植物以其抗菌和抗氧化特性而闻名。方法从 2022 年 11 月到 12 月，我们使用布尔运算符和 "精油"、"生物活性"、"生物活性"、"抗氧化活性"、"抗菌活性"、"抗真菌活性"、"抗微生物活性 "和 "埃塞俄比亚 "等术语，从 PubMed/Medline、Science Direct、SciVerse、Web of Science 和 Google Scholar 检索到 28 项研究。'结果具有抗菌活性的环氧乙烷包括：水生薄荷（Mentha aquatica）、芹菜（Apium leptophyllum）、网纹柑（Citrus reticulata）、艾叶薄荷（Mentha arvensis）、长叶薄荷（Mentha longifolia）、胡椒薄荷（Mentha piperita）、辣薄荷（Mentha spicata）、油橄榄（Olea europaea）、集成牡丹（Otostegia integrifolia）、十二芒草（Phytolacca dodecandra）、马鲁巴草（Plectranthus marrubatus）、丹参（Salvia nilotica）、丹参（Salvia officinalis）和丹参（Salvia schimperi）（MICs < 0.005 至 0.064 毫克/毫升）。在抗真菌活性方面，值得注意的 EO 包括 Acokanthera schimperi、Cinnamomum zeylanicum、C. reticulata、C. reticulata、O. europaea、O. integrifolia、P. dodecandra、P. marrubatus、Satureja paradoxa 和 Thymus schimperi（MICs < 1 mg/mL）。抗氧化精油是苦艾蒿、阿比西尼亚蒿、阿弗拉蒿、芫荽、莪术、杜松、椴树、罗勒草、欧芹、玫瑰麝香、S. officinalis、阿比西尼亚和 S. paradoxa 的精油。所有这些精油的 IC50 值为 0.05 毫克/毫升。结论本综述确定了许多埃塞俄比亚芳香植物的环氧乙烷，它们具有良好的抗菌和抗氧化活性，需要进行更多的临床前测试研究，并最终应用于临床。

{"title":"A review article on the antimicrobial and antioxidant essential oils of aromatic plants in Ethiopia","authors":"Destaw Damtie","doi":"10.1016/j.hermed.2024.100948","DOIUrl":"10.1016/j.hermed.2024.100948","url":null,"abstract":"<div><h3>Introduction</h3><div>Ethiopia has eight vegetation types across altitudes (< 400 - 4533 m). Consequently, it is biologically rich (> 6500–7000 plant species) with 12–19% endemicity. While medicinal plant knowledge in Ethiopia is partially documented, much remains unexplored. This study reviews the essential oils (EOs) of aromatic plants in Ethiopia, known for their antimicrobial and antioxidant properties.</div></div><div><h3>Methods</h3><div>From November to December 2022, we retrieved 28 studies from PubMed/Medline, Science Direct, SciVerse, Web of Science, and Google Scholar using boolean operators and terms such as ‘essential oil,’ ‘biological activities,’ ‘bioactivy,’ ‘antioxidant activities,’ ‘antibacterial activities,’ ‘antifungal activities,’ ‘antimicrobial activities,’ and ‘Ethiopia.’</div></div><div><h3>Results</h3><div>Promising antibacterial EOs include <em>Mentha aquatica</em>, <em>Apium leptophyllum</em>, <em>Citrus reticulata</em>, <em>Mentha arvensis</em>, <em>Mentha longifolia, Mentha piperita, Mentha spicata, Olea europaea</em>, <em>Otostegia integrifolia, Phytolacca dodecandra</em>, <em>Plectranthus marrubatus</em>, <em>Salvia nilotica</em>, <em>Salvia officinalis</em>, and <em>Salvia schimperi</em> (MICs < 0.005 to 0.064 mg/mL). For antifungal activity, notable EOs include <em>Acokanthera schimperi, Cinnamomum zeylanicum, C. reticulata, C. reticulata, O. europaea, O. integrifolia, P. dodecandra, P. marrubatus, Satureja paradoxa,</em> and <em>Thymus schimperi</em> (MICs < 1 mg/mL). Antioxidant essential oils were those of <em>Artemisia absinthium</em> L., <em>Artemisia abyssinica</em>, <em>Artemisia afra, Coriandrum sativum, Curcuma domestica, Juniperus procera</em>, <em>Lippia adoensis</em>, <em>Ocimum basilicum</em>, <em>O. europaea</em>, <em>Rosmarinus officinalis</em>, <em>S. officinalis</em>, <em>Satureja abyssinica</em>, and <em>S. paradoxa.</em> The IC<sub>50</sub> of all these essential oils was < 0.05 mg/mL.</div></div><div><h3>Conclusion</h3><div>The present review identified the EOs of many Ethiopian aromatic plants with promising antimicrobial and antioxidant activities that demand more enquiry for preclinical testing, and eventually, clinical applications.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100948"},"PeriodicalIF":2.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of Lippia multiflora in the management of stage I hypertension: outcomes of a randomised controlled trial 多花菩提子治疗 I 期高血压的安全性和疗效：随机对照试验的结果

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-25 DOI: 10.1016/j.hermed.2024.100947

Ama Kyeraa Thomford , Kwesi Prah Thomford , Andrews Ebo Tetteh , Rosemary Sorkpor , Joseph Yorke

Introduction

Hypertension is a growing public health problem in the developing world. The chronic nature of the disease has been a driver for the use of traditional medicines. Clinical validation of such products for their safety and efficacy is thus of public health importance. We report on the clinical safety and effectiveness of a Lippia multiflora-based herbal antihypertensive (LMT-19).

Methods

A randomised controlled study was conducted among 80 volunteers clinically diagnosed, per the WHO criteria, with stage I hypertension. Participants received either an aqueous infusion of LMT-19 plus a standard lifestyle and dietary recommendation based on a Dietary Approaches to Stop Hypertension (DASH) diet or the lifestyle and dietary recommendation alone.

Results

The use of LMT-19 resulted in a significant decline of blood pressure over a 60-day period. Diastolic blood pressure in the LMT-19 group was found to be significantly lower compared to the control (mean diff: 8.25 (±1.50); P ≤ 0.001). Systolic blood pressure was also significantly better compared to the control group (mean diff: 12.70 ± 2.02; P ≤ 0.001). The product was also well tolerated as no adverse drug reactions were also recorded during the study.

Conclusion

These outcomes suggest LMT-19 as a potential alternative remedy for management of stage I hypertension.

Clinical trial registration

Pan-African Clinical Trial Registry, PACTR202107733803271.

导言高血压是发展中国家日益严重的公共卫生问题。这种疾病的慢性性质推动了传统药物的使用。因此，对此类产品的安全性和有效性进行临床验证具有重要的公共卫生意义。我们报告了以多花菩提草为基础的草药降压药（LMT-19）的临床安全性和有效性。方法在 80 名根据世界卫生组织标准临床诊断为 I 期高血压的志愿者中进行了随机对照研究。参加者接受了 LMT-19 的水溶液注射，同时还接受了基于饮食疗法（DASH）的标准生活方式和饮食建议，或者只接受了生活方式和饮食建议。与对照组相比，LMT-19 组的舒张压明显降低（平均差值为 8.25（±1.50））：8.25 (±1.50); P ≤ 0.001).收缩压也明显优于对照组（平均差：12.70 ± 2.02；P ≤ 0.001）。结论这些结果表明，LMT-19 是治疗 I 期高血压的潜在替代药物。临床试验注册泛非临床试验注册中心，PACTR202107733803271。

{"title":"Safety and efficacy of Lippia multiflora in the management of stage I hypertension: outcomes of a randomised controlled trial","authors":"Ama Kyeraa Thomford , Kwesi Prah Thomford , Andrews Ebo Tetteh , Rosemary Sorkpor , Joseph Yorke","doi":"10.1016/j.hermed.2024.100947","DOIUrl":"10.1016/j.hermed.2024.100947","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertension is a growing public health problem in the developing world. The chronic nature of the disease has been a driver for the use of traditional medicines. Clinical validation of such products for their safety and efficacy is thus of public health importance. We report on the clinical safety and effectiveness of a <em>Lippia multiflora-</em>based herbal antihypertensive <em>(LMT-19)</em>.</div></div><div><h3>Methods</h3><div>A randomised controlled study was conducted among 80 volunteers clinically diagnosed, per the WHO criteria, with stage I hypertension. Participants received either an aqueous infusion of <em>LMT-19</em> plus a standard lifestyle and dietary recommendation based on a Dietary Approaches to Stop Hypertension (DASH) diet or the lifestyle and dietary recommendation alone.</div></div><div><h3>Results</h3><div>The use of <em>LMT-19</em> resulted in a significant decline of blood pressure over a 60-day period. Diastolic blood pressure in the <em>LMT-19</em> group was found to be significantly lower compared to the control (<em>mean diff</em>: 8.25 (±1.50); <em>P</em> ≤ 0.001). Systolic blood pressure was also significantly better compared to the control group (<em>mean diff:</em> 12.70 ± 2.02; <em>P</em> ≤ 0.001). The product was also well tolerated as no adverse drug reactions were also recorded during the study.</div></div><div><h3>Conclusion</h3><div>These outcomes suggest <em>LMT-19</em> as a potential alternative remedy for management of stage I hypertension.</div></div><div><h3>Clinical trial registration</h3><div>Pan-African Clinical Trial Registry, PACTR202107733803271.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100947"},"PeriodicalIF":2.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of compound xueshuantong capsule in reducing cardiovascular diseases and associated ophthalmic complications: a multi-centre retrospective study 复方雪莲通胶囊对减少心血管疾病及相关眼科并发症的疗效：一项多中心回顾性研究

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-20 DOI: 10.1016/j.hermed.2024.100943

Boshi Liu , Min Zhu , Fei Gao , Shaolin Du , Minyu Chen , Shuo Chen , Richeng Yu , Long Pang , Juping Liu , Xiaorong Li

Introduction

This study aims to explore the effectiveness and value of compound xueshuantong capsule (CXC) in the treatment of diseases by evaluating its potential to reduce cardiovascular diseases (CVDs) and ophthalmic complications.

Methods

A total of 5 104 patients with fundus vascular diseases including retinal artery occlusion (RAO), retinal vein occlusion (RVO), diabetic retinopathy (DR), hypertensive retinopathy, periphlebitis of retina, age-related macular degeneration (AMD), central serous chorioretinopathy (CSC), and anterior ischaemic optic neuropathy (AION) were enroled across seven hospitals from 2002 to 2022. All participants were randomised categorised into two groups: CXC combination group (CXC alone or combined with hypoglycemic, lipid-lowering, or anti-hypertensive drugs, and other microcirculation and fundus angiopathy medications), and non-CXC group (only taking the above-mentioned medicines).

Results

Kaplan-Meier curves illustrated a lower incidence of cardio-cerebrovascular events and ophthalmic complications in CXC group compared with other group at a significant difference observed. Further stratification revealed a decreased risk of ophthalmic complications in CXC group, and supported by multivariate analysis through adjusting for baseline confounding factors.

Discussion/Conclusions

Our findings further confirmed the potential value of CXC in treating cardio-cerebrovascular diseases and associated ophthalmic complications, and accompanying with less side effects at the same time.

引言本研究旨在通过评估复方雪莲通胶囊（CXC）在减少心血管疾病（CVDs）和眼科并发症方面的潜力，探讨其在疾病治疗中的有效性和价值。方法从 2002 年到 2022 年，七家医院共招募了 5 104 名眼底血管疾病患者，包括视网膜动脉闭塞 (RAO)、视网膜静脉闭塞 (RVO)、糖尿病视网膜病变 (DR)、高血压视网膜病变、视网膜周围静脉炎、老年性黄斑变性 (AMD)、中心性浆液性脉络膜视网膜病变 (CSC) 和前部缺血性视神经病变 (AION)。所有参与者被随机分为两组：结果卡普兰-梅耶曲线显示，CXC 组与其他组相比，心脑血管事件和眼科并发症的发生率较低，差异显著。讨论/结论我们的研究结果进一步证实了 CXC 在治疗心脑血管疾病和相关眼科并发症方面的潜在价值，同时副作用较小。

{"title":"Efficacy of compound xueshuantong capsule in reducing cardiovascular diseases and associated ophthalmic complications: a multi-centre retrospective study","authors":"Boshi Liu , Min Zhu , Fei Gao , Shaolin Du , Minyu Chen , Shuo Chen , Richeng Yu , Long Pang , Juping Liu , Xiaorong Li","doi":"10.1016/j.hermed.2024.100943","DOIUrl":"10.1016/j.hermed.2024.100943","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to explore the effectiveness and value of compound xueshuantong capsule (CXC) in the treatment of diseases by evaluating its potential to reduce cardiovascular diseases (CVDs) and ophthalmic complications.</div></div><div><h3>Methods</h3><div>A total of 5104 patients with fundus vascular diseases including retinal artery occlusion (RAO), retinal vein occlusion (RVO), diabetic retinopathy (DR), hypertensive retinopathy, periphlebitis of retina, age-related macular degeneration (AMD), central serous chorioretinopathy (CSC), and anterior ischaemic optic neuropathy (AION) were enroled across seven hospitals from 2002 to 2022. All participants were randomised categorised into two groups: CXC combination group (CXC alone or combined with hypoglycemic, lipid-lowering, or anti-hypertensive drugs, and other microcirculation and fundus angiopathy medications), and non-CXC group (only taking the above-mentioned medicines).</div></div><div><h3>Results</h3><div>Kaplan-Meier curves illustrated a lower incidence of cardio-cerebrovascular events and ophthalmic complications in CXC group compared with other group at a significant difference observed. Further stratification revealed a decreased risk of ophthalmic complications in CXC group, and supported by multivariate analysis through adjusting for baseline confounding factors.</div></div><div><h3>Discussion/Conclusions</h3><div>Our findings further confirmed the potential value of CXC in treating cardio-cerebrovascular diseases and associated ophthalmic complications, and accompanying with less side effects at the same time.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100943"},"PeriodicalIF":2.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemocompatibility and hemorheological activity of aqueous extracts from Phyllanthus sellowianus: effects on in vitro glycated erythrocytes 黄连水提取物的血液相容性和血液流变学活性：对体外糖化红细胞的影响

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-19 DOI: 10.1016/j.hermed.2024.100945

Hermano Mascaro Grosso , Patricia Buszniez , Bibiana D. Riquelme

Introduction

Phyllanthus sellowianus (Klotzsch) Müll Arg. is an Argentinian and Brazilian native plant used to treat diabetes. In vascular diseases like diabetes, erythrocytes form anomalous aggregates resistant to dissociation, associated with high glucose levels. This work aims to evaluate the hemocompatibility and hemorheological activity of aqueous extracts from P. sellowianus and its anti-diabetic activity using in vitro glycated erythrocytes as occur by hyperglycemia.

Methods

For this work, P. sellowianus specimens were collected on the Nogoyá River coast, Argentina, and morphoanatomical identified. Infusion, maceration, digestion, and cooking extracts were prepared with collected leaves and bark using saline as solvent. The osmolality and pH of the extracts were adjusted to an adequate interaction with human cells. Red blood cells (RBCs) from healthy donors (n=3) were used and incubated with glucose solution for in vitro simulation of the hyperglycemia effects. RBCs were incubated with the aqueous extracts to assess their hemocompatibility. Also, glycated RBCs were incubated with the extracts to analyze their anti-diabetic properties. Erythrocyte Rheometer and Optical Chip Aggregameter were used for the hemorheological evaluation.

Results

Assays with the different P. sellowianus extracts modified the viscoelasticity and aggregation of RBCs. Moreover, in some cases, P. sellowianus extracts reversed the in vitro glycation effect and hemorheological parameters got nearer control values.

Conclusion

These results would be helpful for the development of pharmaceutical formulations using this species or its phytocomponents. They also give relevant information to understand the action mechanisms through which these extracts or their components can be used as anti-diabetics in Phytomedicine.

导言Phyllanthus sellowianus (Klotzsch) Müll Arg.是一种阿根廷和巴西本地植物，用于治疗糖尿病。在糖尿病等血管疾病中，红细胞会形成异常聚集，无法解离，这与高血糖水平有关。本研究旨在评估黄皮属植物水提取物的血液相容性和血液流变学活性，以及利用高血糖引起的体外糖化红细胞评估其抗糖尿病活性。以生理盐水为溶剂，对采集的树叶和树皮进行浸泡、浸渍、消化和烹饪提取。萃取物的渗透压和 pH 值经过调整，以便与人体细胞充分互动。使用健康捐献者（n=3）的红细胞（RBCs）并与葡萄糖溶液培养，以体外模拟高血糖效应。将红细胞与水提取物培养，以评估其血液相容性。此外，还将糖化的红细胞与提取物培养，以分析它们的抗糖尿病特性。红细胞流变仪和光学芯片聚集仪用于血液流变学评估。此外，在某些情况下，黄皮提取物逆转了体外糖化效应，血液流变学参数接近控制值。这些结果还提供了相关信息，有助于了解这些提取物或其成分在植物药中用作抗糖尿病药物的作用机制。

{"title":"Hemocompatibility and hemorheological activity of aqueous extracts from Phyllanthus sellowianus: effects on in vitro glycated erythrocytes","authors":"Hermano Mascaro Grosso , Patricia Buszniez , Bibiana D. Riquelme","doi":"10.1016/j.hermed.2024.100945","DOIUrl":"10.1016/j.hermed.2024.100945","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Phyllanthus sellowianus</em> (Klotzsch) Müll Arg. is an Argentinian and Brazilian native plant used to treat diabetes. In vascular diseases like diabetes, erythrocytes form anomalous aggregates resistant to dissociation, associated with high glucose levels. This work aims to evaluate the hemocompatibility and hemorheological activity of aqueous extracts from <em>P. sellowianus</em> and its anti-diabetic activity using <em>in vitro</em> glycated erythrocytes as occur by hyperglycemia.</div></div><div><h3>Methods</h3><div>For this work, <em>P. sellowianus</em> specimens were collected on the Nogoyá River coast, Argentina, and morphoanatomical identified. Infusion, maceration, digestion, and cooking extracts were prepared with collected leaves and bark using saline as solvent. The osmolality and pH of the extracts were adjusted to an adequate interaction with human cells. Red blood cells (RBCs) from healthy donors (n=3) were used and incubated with glucose solution for <em>in vitro</em> simulation of the hyperglycemia effects. RBCs were incubated with the aqueous extracts to assess their hemocompatibility. Also, glycated RBCs were incubated with the extracts to analyze their anti-diabetic properties. Erythrocyte Rheometer and Optical Chip Aggregameter were used for the hemorheological evaluation.</div></div><div><h3>Results</h3><div>Assays with the different <em>P. sellowianus</em> extracts modified the viscoelasticity and aggregation of RBCs. Moreover, in some cases, <em>P. sellowianus</em> extracts reversed the <em>in vitro</em> glycation effect and hemorheological parameters got nearer control values.</div></div><div><h3>Conclusion</h3><div>These results would be helpful for the development of pharmaceutical formulations using this species or its phytocomponents. They also give relevant information to understand the action mechanisms through which these extracts or their components can be used as anti-diabetics in Phytomedicine.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100945"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of herbal medicine in relieving complications related to cancer treatments: an evidence-based systematic review 草药对缓解癌症治疗并发症的作用：循证系统综述

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-19 DOI: 10.1016/j.hermed.2024.100944

Hamed Delam , Zahra Moradi Kouchi , Hamed Safari

Introduction

Today, cancer patients suffer from acute or chronic complications related to these treatments due to the use of common cancer treatments, including chemotherapy and radiation therapy. Some people use complementary medicine such as herbal medicine to reduce or eliminate these side effects. Therefore, the current study was designed with the aim of determining the effects of herbal medicines on complications related to cancer treatments in 2023.

Methods

This study is an evidence-based systematic review designed in 2023. Studies of randomised controlled trials that were published in four reliable databases PubMed/Medline, Scopus, ISI and Google Scholar were selected for review. Finally, 43 articles were selected for final review and data extraction. The herbal medicines considered for the present study included Senna, ginger, lavender, chamomile, ginseng, mint, Rikkunshito, Aloe vera and ginseng.

Results

The results of most of the trials showed the favourable effects of herbal medicines in reducing the complications associated with cancer treatments. Also, no serious side effects were reported after taking this class of drugs. Although a large number of people use complementary treatments, especially medicinal plants, and know it as a safe treatment, but patients and medical staff have little information about the effect of medicinal plants on the symptoms of diseases. This situation can lead to improper use of herbal medicines.

Conclusions

In general, the results of the study showed that medicinal plants as a complementary treatment can have a positive effect on the improvement of symptoms and complications related to cancer treatments. Clinicians can suggest the use of medicinal plants along with other standard drugs or even alone to patients and reduce the side effects and costs of patients to a great extent.

导言如今，由于使用化疗和放疗等常见的癌症治疗方法，癌症患者会出现与这些治疗方法相关的急性或慢性并发症。一些人使用草药等辅助药物来减轻或消除这些副作用。因此，本研究旨在确定草药对 2023 年癌症治疗相关并发症的影响。我们选择了发表在 PubMed/Medline、Scopus、ISI 和 Google Scholar 四个可靠数据库中的随机对照试验研究进行综述。最后，选出 43 篇文章进行最终审查和数据提取。本研究中考虑的草药包括番泻叶、生姜、薰衣草、甘菊、人参、薄荷、利君度、芦荟和人参。此外，服用这类药物后没有出现严重副作用的报告。虽然很多人使用辅助疗法，尤其是药用植物，并知道这是一种安全的治疗方法，但病人和医务人员对药用植物对疾病症状的影响了解甚少。结论总体而言，研究结果表明，药用植物作为一种辅助治疗手段，对改善癌症治疗相关症状和并发症有积极作用。临床医生可以建议患者在使用其他标准药物的同时使用药用植物，甚至单独使用，从而在很大程度上减少副作用，降低患者的治疗费用。

{"title":"The effect of herbal medicine in relieving complications related to cancer treatments: an evidence-based systematic review","authors":"Hamed Delam , Zahra Moradi Kouchi , Hamed Safari","doi":"10.1016/j.hermed.2024.100944","DOIUrl":"10.1016/j.hermed.2024.100944","url":null,"abstract":"<div><h3>Introduction</h3><div>Today, cancer patients suffer from acute or chronic complications related to these treatments due to the use of common cancer treatments, including chemotherapy and radiation therapy. Some people use complementary medicine such as herbal medicine to reduce or eliminate these side effects. Therefore, the current study was designed with the aim of determining the effects of herbal medicines on complications related to cancer treatments in 2023.</div></div><div><h3>Methods</h3><div>This study is an evidence-based systematic review designed in 2023. Studies of randomised controlled trials that were published in four reliable databases PubMed/Medline, Scopus, ISI and Google Scholar were selected for review. Finally, 43 articles were selected for final review and data extraction. The herbal medicines considered for the present study included Senna, ginger, lavender, chamomile, ginseng, mint, Rikkunshito, Aloe vera and ginseng.</div></div><div><h3>Results</h3><div>The results of most of the trials showed the favourable effects of herbal medicines in reducing the complications associated with cancer treatments. Also, no serious side effects were reported after taking this class of drugs. Although a large number of people use complementary treatments, especially medicinal plants, and know it as a safe treatment, but patients and medical staff have little information about the effect of medicinal plants on the symptoms of diseases. This situation can lead to improper use of herbal medicines.</div></div><div><h3>Conclusions</h3><div>In general, the results of the study showed that medicinal plants as a complementary treatment can have a positive effect on the improvement of symptoms and complications related to cancer treatments. Clinicians can suggest the use of medicinal plants along with other standard drugs or even alone to patients and reduce the side effects and costs of patients to a great extent.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100944"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double-Blind, Randomised, Placebo-Controlled Study Evaluating the Efficacy of an Early Treatment Using Herbal Supplement in the Prevention of Post-traumatic Stress Disorder in the Emergency Department (PHYTéS Study) 双盲、随机、安慰剂对照研究：评估在急诊科使用草药补充剂预防创伤后应激障碍的早期治疗效果（PHYTéS 研究）

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-19 DOI: 10.1016/j.hermed.2024.100946

R. Boukef , I. Trabelsi , R. Youssef , H. Yaakoubi , A. Sekma , R. Jaballah , K.B. Ali , H. Ben Salah , S. Mabsout , F. Boukadida , Z. Dhifaoui , F. Graa , S. Nouira , L. Boukadida , A. Zorgati

Introduction

Post-traumatic stress disorder (PTSD) poses a major challenge to mental health. Current treatments primarily address PTSD symptoms after their onset, and there is a critical need for effective early intervention strategies. While several studies have explored various therapies, including pharmacological and psychotherapeutic approaches, there is a notable gap in research regarding preventive interventions. This study investigates the efficacy of Aleozen®, a herbal supplement, in preventing PTSD among high-risk individuals. Aleozen® contains a blend of plant extracts such as Griffonia simplicifolia, Rhodiola rosea, Gentiana lutea, Crataegus oxyacantha, Eschscholtzia californica, and Melissa officinalis, which have shown promise in mitigating stress and anxiety.

Methods

In a randomized controlled trial, high-risk participants who experienced recent trauma were administered Aleozen® or a placebo over a 12-week period. Participants were assessed using standardized PTSD symptom scales and physiological markers of stress at baseline, mid-point, and end of the study. The primary outcome was the reduction in PTSD symptoms compared to the placebo group.

Results

Participants receiving Aleozen® exhibited a statistically significant reduction in PTSD symptom severity compared to the placebo group. The mean reduction in PTSD symptom scores was 35% in the Aleozen® group versus 12% in the placebo group (p < 0.01). Additionally, Aleozen® was associated with improvements in secondary outcomes, including reduced anxiety and better sleep quality. There were no significant adverse effects reported, suggesting that Aleozen® is both effective and well-tolerated.

Conclusions

This study demonstrates that Aleozen® significantly reduces PTSD symptoms and related distress in high-risk individuals when administered early after trauma.

Clinical registration Number

It was recorded in the ClinicalTrials.gov register (NCT03724448) on June 26, 2018.

导言创伤后应激障碍（PTSD）对心理健康构成了重大挑战。目前的治疗方法主要针对创伤后应激障碍发病后的症状，因此亟需有效的早期干预策略。虽然已有多项研究探讨了包括药物和心理治疗方法在内的各种疗法，但有关预防性干预措施的研究却存在明显空白。本研究调查了草药补充剂 Aleozen® 对高危人群预防创伤后应激障碍的功效。Aleozen® 包含多种植物提取物，如 Griffonia simplicifolia、Rhodiola rosea、Gentiana lutea、Crataegus oxyacantha、Eschscholtzia californica 和 Melissa officinalis。在基线、中期和研究结束时，使用标准化创伤后应激障碍症状量表和压力生理指标对参与者进行评估。主要结果是与安慰剂组相比，创伤后应激障碍症状有所减轻。结果与安慰剂组相比，接受 Aleozen® 治疗的参与者的创伤后应激障碍症状严重程度在统计学上有显著降低。Aleozen®组的创伤后应激障碍症状评分平均降低了35%，而安慰剂组仅降低了12%（p < 0.01）。此外，Aleozen®还改善了次要结果，包括减轻焦虑和提高睡眠质量。没有报告明显的不良反应，表明Aleozen®既有效又耐受性良好。结论本研究表明，创伤后早期给药Aleozen®可显著减轻高危人群的创伤后应激障碍症状和相关困扰。临床注册号于2018年6月26日在ClinicalTrials.gov注册中心（NCT03724448）登记。

{"title":"Double-Blind, Randomised, Placebo-Controlled Study Evaluating the Efficacy of an Early Treatment Using Herbal Supplement in the Prevention of Post-traumatic Stress Disorder in the Emergency Department (PHYTéS Study)","authors":"R. Boukef , I. Trabelsi , R. Youssef , H. Yaakoubi , A. Sekma , R. Jaballah , K.B. Ali , H. Ben Salah , S. Mabsout , F. Boukadida , Z. Dhifaoui , F. Graa , S. Nouira , L. Boukadida , A. Zorgati","doi":"10.1016/j.hermed.2024.100946","DOIUrl":"10.1016/j.hermed.2024.100946","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-traumatic stress disorder (PTSD) poses a major challenge to mental health. Current treatments primarily address PTSD symptoms after their onset, and there is a critical need for effective early intervention strategies. While several studies have explored various therapies, including pharmacological and psychotherapeutic approaches, there is a notable gap in research regarding preventive interventions. This study investigates the efficacy of Aleozen®, a herbal supplement, in preventing PTSD among high-risk individuals. Aleozen® contains a blend of plant extracts such as Griffonia simplicifolia, Rhodiola rosea, Gentiana lutea, Crataegus oxyacantha, Eschscholtzia californica, and Melissa officinalis, which have shown promise in mitigating stress and anxiety.</div></div><div><h3>Methods</h3><div>In a randomized controlled trial, high-risk participants who experienced recent trauma were administered Aleozen® or a placebo over a 12-week period. Participants were assessed using standardized PTSD symptom scales and physiological markers of stress at baseline, mid-point, and end of the study. The primary outcome was the reduction in PTSD symptoms compared to the placebo group.</div></div><div><h3>Results</h3><div>Participants receiving Aleozen® exhibited a statistically significant reduction in PTSD symptom severity compared to the placebo group. The mean reduction in PTSD symptom scores was 35% in the Aleozen® group versus 12% in the placebo group (p < 0.01). Additionally, Aleozen® was associated with improvements in secondary outcomes, including reduced anxiety and better sleep quality. There were no significant adverse effects reported, suggesting that Aleozen® is both effective and well-tolerated.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that Aleozen® significantly reduces PTSD symptoms and related distress in high-risk individuals when administered early after trauma.</div></div><div><h3>Clinical registration Number</h3><div>It was recorded in the ClinicalTrials.gov register (NCT03724448) on June 26, 2018.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100946"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial activity and molecular docking analysis of Salsola kali: investigating potent biological interactions and chemical composition Salsola kali 的抗菌活性和分子对接分析：研究有效的生物相互作用和化学成分

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-19 DOI: 10.1016/j.hermed.2024.100942

Erdi Can Aytar , Betül Aydın , Emine Incilay Torunoğlu , Alper Durmaz

Introduction

This study investigates the antioxidant, phenolic, and antimicrobial properties of Salsola kali and examines the molecular binding interactions of its biologically active compounds with various proteins.

Methods

Ethanol extract from the aerial parts of Salsola kali was analyzed for DPPH free radical scavenging activity, iron chelating activity, total phenolic content, and total flavonoid content. Antimicrobial activity was tested against several bacterial strains, and the active components of the extract were identified through chemical analysis. Molecular docking studies assessed the binding interactions of these compounds with different protein targets.

Results

The ethanol extract exhibited strong antioxidant activity, with a DPPH IC₅₀ value of 0.12 ± 0.02 μg/mL and an iron chelating IC₅₀ value of 3.96 ± 0.19 mg/ml. The total phenolic content was measured at 153.61 ± 5.41 mg GAE/g extract, while the total flavonoid content was 303.25 ± 12.68 mg QE/g extract. Significant antimicrobial activity was observed against E. coli (MIC = 25 μg/ml) and S. aureus (MIC = 6.25 μg/ml). The analysis identified 15 biologically active compounds, with 2-methoxy-1,3-dioxolane and Nonane, 3-methyl-5-propyl as the most abundant. Molecular docking studies revealed strong binding affinities with various proteins, with binding energies ranging from -4.9 to -6.7 kcal/mol.

Conclusion

The phenolic and flavonoid content of S. kali indicates significant antioxidant and antimicrobial activities. The identified compounds show promising binding interactions with proteins, suggesting potential pharmacological applications.

引言本研究调查了 Salsola kali 的抗氧化、酚类和抗菌特性，并研究了其生物活性化合物与各种蛋白质的分子结合相互作用。方法分析了 Salsola kali 气生部分的乙醇提取物的 DPPH 自由基清除活性、铁螯合活性、总酚含量和总黄酮含量。对几种细菌菌株进行了抗菌活性测试，并通过化学分析确定了提取物的活性成分。分子对接研究评估了这些化合物与不同蛋白质靶点的结合相互作用。结果乙醇提取物具有很强的抗氧化活性，DPPH IC50 值为 0.12 ± 0.02 μg/mL，铁螯合 IC50 值为 3.96 ± 0.19 mg/ml。总酚含量为 153.61 ± 5.41 毫克 GAE/克提取物，总黄酮含量为 303.25 ± 12.68 毫克 QE/克提取物。对大肠杆菌（MIC = 25 μg/ml）和金黄色葡萄球菌（MIC = 6.25 μg/ml）具有显著的抗菌活性。分析确定了 15 种具有生物活性的化合物，其中以 2-甲氧基-1,3-二氧戊环和 3-甲基-5-丙基壬烷含量最高。分子对接研究显示，这些化合物与各种蛋白质的结合亲和力很强，结合能在 -4.9 至 -6.7 kcal/mol 之间。鉴定出的化合物与蛋白质的结合相互作用前景广阔，具有潜在的药理应用价值。

{"title":"Antimicrobial activity and molecular docking analysis of Salsola kali: investigating potent biological interactions and chemical composition","authors":"Erdi Can Aytar , Betül Aydın , Emine Incilay Torunoğlu , Alper Durmaz","doi":"10.1016/j.hermed.2024.100942","DOIUrl":"10.1016/j.hermed.2024.100942","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigates the antioxidant, phenolic, and antimicrobial properties of Salsola kali and examines the molecular binding interactions of its biologically active compounds with various proteins.</div></div><div><h3>Methods</h3><div>Ethanol extract from the aerial parts of <em>Salsola kali</em> was analyzed for DPPH free radical scavenging activity, iron chelating activity, total phenolic content, and total flavonoid content. Antimicrobial activity was tested against several bacterial strains, and the active components of the extract were identified through chemical analysis. Molecular docking studies assessed the binding interactions of these compounds with different protein targets.</div></div><div><h3>Results</h3><div>The ethanol extract exhibited strong antioxidant activity, with a DPPH IC<sub>50</sub> value of 0.12 ± 0.02 μg/mL and an iron chelating IC<sub>50</sub> value of 3.96 ± 0.19 mg/ml. The total phenolic content was measured at 153.61 ± 5.41 mg GAE/g extract, while the total flavonoid content was 303.25 ± 12.68 mg QE/g extract. Significant antimicrobial activity was observed against <em>E. coli</em> (MIC = 25 μg/ml) and <em>S. aureus</em> (MIC = 6.25 μg/ml). The analysis identified 15 biologically active compounds, with 2-methoxy-1,3-dioxolane and Nonane, 3-methyl-5-propyl as the most abundant. Molecular docking studies revealed strong binding affinities with various proteins, with binding energies ranging from -4.9 to -6.7 kcal/mol.</div></div><div><h3>Conclusion</h3><div>The phenolic and flavonoid content of <em>S. kali</em> indicates significant antioxidant and antimicrobial activities. The identified compounds show promising binding interactions with proteins, suggesting potential pharmacological applications.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100942"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential cytotoxic effects of Garcinia mangostana pericarp extract on leukaemic versus normal human cell lines: insights into selective anticancer activity 芒果果皮提取物对白血病细胞系和正常人细胞系的不同细胞毒性作用：对选择性抗癌活性的认识

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-18 DOI: 10.1016/j.hermed.2024.100937

Sabrina D. Zeppa , Matteo Micucci , Fabio Ferrini , Anna M. Gioacchini , Giovanni Piccoli , Lucia Potenza , Alessia Bartolacci , Giosuè Annibalini , Asher A. Rehman , Cinzia Calcabrini , Vilberto Stocchi , Piero Sestili

Introduction

Garcinia mangostana L. is widely recognised for its traditional medicinal uses and growing relevance in the nutraceutical sector. This research endeavour is designed to scrutinise the phytochemical composition and cytotoxic effects of an alcoholic extract derived from the pericarps of G. mangostana (ME) on leukaemic cell lines.

Methods

G. mangostana L. pericarps were subjected to ethanol extraction, and subsequent compound identification was conducted via Capillary Liquid Chromatography-Electrospray Ionisation-Quadrupole Time-of-Flight Tandem Mass Spectrometry (CapLC-ESI-QTOF-MS/MS). In parallel, the extract was fractionated through High-Performance Liquid Chromatography (HPLC). Furthermore, U937, Jurkat and normal human umbilical vein endothelial cell (HUVEC) lines were exposed to varying concentrations of the extract to assess cell proliferation, viability, cytotoxicity, and apoptotic DNA damage.

Results

Investigations confirmed the presence of various xanthones, including β-mangostin, α-mangostin, and garcinone E. Significantly, ME displayed pronounced cytotoxic effects specifically on leukaemic cells, distinguishing its impact on malignant cells as opposed to non-malignant ones, and facilitated apoptotic DNA fragmentation. Moreover, the whole extract consistently displayed greater cytotoxicity compared to individual fractions.

Conclusion

According to the results obtained ME selective cytotoxicity against cancer cell lines and greater biological activity than the single compounds in the extract. These findings underscore ME's potential in cancer prevention, complementing dietary strategies ahead of pharmaceutical interventions.

引言藤黄属植物（Garcinia mangostana L.）因其传统的药用价值和在营养保健领域日益增长的相关性而得到广泛认可。本研究旨在仔细研究从芒果树果皮（ME）中提取的酒精提取物的植物化学成分和对白血病细胞系的细胞毒性作用。方法对芒果树果皮进行乙醇提取，然后通过毛细管液相色谱-电喷雾离子化-四极杆飞行时间串联质谱法（CapLC-ESI-QTOF-MS/MS）进行化合物鉴定。同时，提取物还通过高效液相色谱法（HPLC）进行了分馏。此外，将 U937、Jurkat 和正常人脐静脉内皮细胞 (HUVEC) 株暴露于不同浓度的提取物中，以评估细胞增殖、活力、细胞毒性和凋亡 DNA 损伤。值得注意的是，ME 对白血病细胞有明显的细胞毒性作用，对恶性细胞的影响有别于对非恶性细胞的影响，并能促进 DNA 的凋亡破碎。此外，与单个馏分相比，整个提取物始终显示出更强的细胞毒性。这些发现凸显了 ME 在预防癌症方面的潜力，在药物干预之前对饮食策略进行了补充。

{"title":"Differential cytotoxic effects of Garcinia mangostana pericarp extract on leukaemic versus normal human cell lines: insights into selective anticancer activity","authors":"Sabrina D. Zeppa , Matteo Micucci , Fabio Ferrini , Anna M. Gioacchini , Giovanni Piccoli , Lucia Potenza , Alessia Bartolacci , Giosuè Annibalini , Asher A. Rehman , Cinzia Calcabrini , Vilberto Stocchi , Piero Sestili","doi":"10.1016/j.hermed.2024.100937","DOIUrl":"10.1016/j.hermed.2024.100937","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Garcinia mangostana L.</em> is widely recognised for its traditional medicinal uses and growing relevance in the nutraceutical sector. This research endeavour is designed to scrutinise the phytochemical composition and cytotoxic effects of an alcoholic extract derived from the pericarps of <em>G. mangostana</em> (ME) on leukaemic cell lines.</div></div><div><h3>Methods</h3><div><em>G. mangostana</em> L. pericarps were subjected to ethanol extraction, and subsequent compound identification was conducted via Capillary Liquid Chromatography-Electrospray Ionisation-Quadrupole Time-of-Flight Tandem Mass Spectrometry (CapLC-ESI-QTOF-MS/MS). In parallel, the extract was fractionated through High-Performance Liquid Chromatography (HPLC). Furthermore, U937, Jurkat and normal human umbilical vein endothelial cell (HUVEC) lines were exposed to varying concentrations of the extract to assess cell proliferation, viability, cytotoxicity, and apoptotic DNA damage.</div></div><div><h3>Results</h3><div>Investigations confirmed the presence of various xanthones, including β-mangostin, α-mangostin, and garcinone E. Significantly, ME displayed pronounced cytotoxic effects specifically on leukaemic cells, distinguishing its impact on malignant cells as opposed to non-malignant ones, and facilitated apoptotic DNA fragmentation. Moreover, the whole extract consistently displayed greater cytotoxicity compared to individual fractions.</div></div><div><h3>Conclusion</h3><div>According to the results obtained ME selective cytotoxicity against cancer cell lines and greater biological activity than the single compounds in the extract. These findings underscore ME's potential in cancer prevention, complementing dietary strategies ahead of pharmaceutical interventions.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100937"},"PeriodicalIF":2.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidics assisted green synthesis of copper oxide nanoparticles from the aqueous leaf extract of Ipomoea quamoclit L. with its antimicrobial and antioxidant activity 微流控技术辅助从苕子叶水提取物中绿色合成氧化铜纳米颗粒及其抗菌和抗氧化活性

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-17 DOI: 10.1016/j.hermed.2024.100940

D. Joanna Magdalene, D. Muthuselvam

Introduction

Green nanosynthesis of medicinal plants are useful for the development of antibiotic agents. In this work, we have explored the antimicrobial and antioxidant activity of green synthesised copper oxide (CuO) nanoparticles (NPs) from tropical medicinal plant Ipomoea quamoclit L.

Methods

With the aid of microfluidic technology, a low-cost, polydimethylsiloxane (PDMS) lab-on-chip micromixer for green nanosynthesis of CuO nanoparticle using Ipomoea quamoclit is presented. The UV–Vis characteristics, Fourier Transform Infra-red (FTIR) spectrum, antimicrobial and antioxidant response using DPPH and hydrogen peroxide (H₂O₂) were reported. The antimicrobial efficacy of the synthesised CuO-NPs is tested against two-gram positive bacteria Staphylococcus aureus, Micrococcus luteus, two gram negative bacteria, Enterobacter cloacae, Klebsiella pneumoniae and two fungi species Candida albicans, Aspergillus niger.

Results

UV–Vis spectrum for the synthesised CuO-NPs showed the absorbance at 670 nm, scanning electron microscope (SEM) image analysis and dynamic light scattering (DLS) analysis confirmed the presence of spherical shaped nanoparticle sized between 65 and 94.5 nm. The presence of bioactive functional groups of N-H, C-H and C=0 stretching was identified using Fourier Transform Infrared spectroscopy (FTIR). The maximum mean zone of inhibition obtained was 10.45 ± 0.25 mm for fungi A. niger. The antioxidant activity using DPPH scavenging assay and hydrogen peroxide scavenging assay showed the IC₅₀ value 33.94 μg/ml and 42.54 μg/ml respectively.

Conclusions

The obtained results reveal the potential of CuO-NPs synthesised from I. quamoclit L. as a remarkable medicinal entity for wound healing, respiratory infection, fungal infection and urinary tract infection along with the improved antimicrobial and antioxidant activity.

导言药用植物的绿色纳米合成有助于抗生素制剂的开发。在这项工作中，我们探索了从热带药用植物 Ipomoea quamoclit L 中绿色合成的氧化铜（CuO）纳米粒子（NPs）的抗菌和抗氧化活性。方法借助微流控技术，介绍了一种利用 Ipomoea quamoclit 绿色合成 CuO 纳米粒子的低成本聚二甲基硅氧烷（PDMS）片上微混仪。报告了紫外-可见光特性、傅立叶变换红外光谱（FTIR）、使用 DPPH 和过氧化氢（H2O2）的抗菌和抗氧化反应。测试了合成的 CuO-NPs 对两种革兰氏阳性菌金黄色葡萄球菌、黄体小球菌，两种革兰氏阴性菌泄殖腔肠杆菌、肺炎克雷伯氏菌和两种真菌白色念珠菌、黑曲霉的抗菌效果。结果紫外可见光谱显示合成的 CuO-NPs 的吸光度为 670 纳米，扫描电子显微镜（SEM）图像分析和动态光散射（DLS）分析证实了球形纳米粒子的存在，其尺寸在 65 至 94.5 纳米之间。利用傅立叶变换红外光谱（FTIR）确定了 N-H、C-H 和 C=0 伸展的生物活性官能团的存在。对真菌 A. niger 的最大平均抑制面积为 10.45 ± 0.25 mm。利用 DPPH 清除测定和过氧化氢清除测定的抗氧化活性显示，IC50 值分别为 33.94 μg/ml 和 42.54 μg/ml。

{"title":"Microfluidics assisted green synthesis of copper oxide nanoparticles from the aqueous leaf extract of Ipomoea quamoclit L. with its antimicrobial and antioxidant activity","authors":"D. Joanna Magdalene, D. Muthuselvam","doi":"10.1016/j.hermed.2024.100940","DOIUrl":"10.1016/j.hermed.2024.100940","url":null,"abstract":"<div><h3>Introduction</h3><div>Green nanosynthesis of medicinal plants are useful for the development of antibiotic agents. In this work, we have explored the antimicrobial and antioxidant activity of green synthesised copper oxide (CuO) nanoparticles (NPs) from tropical medicinal plant <em>Ipomoea quamoclit</em> L.</div></div><div><h3>Methods</h3><div>With the aid of microfluidic technology, a low-cost, polydimethylsiloxane (PDMS) lab-on-chip micromixer for green nanosynthesis of CuO nanoparticle using <em>Ipomoea quamoclit</em> is presented. The UV–Vis characteristics, Fourier Transform Infra-red (FTIR) spectrum, antimicrobial and antioxidant response using DPPH and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) were reported. The antimicrobial efficacy of the synthesised CuO-NPs is tested against two-gram positive bacteria <em>Staphylococcus aureus, Micrococcus luteus,</em> two gram negative bacteria, <em>Enterobacter cloacae</em>, <em>Klebsiella pneumoniae</em> and two fungi species <em>Candida albicans</em>, <em>Aspergillus niger.</em></div></div><div><h3>Results</h3><div>UV–Vis spectrum for the synthesised CuO-NPs showed the absorbance at 670 nm, scanning electron microscope (SEM) image analysis and dynamic light scattering (DLS) analysis confirmed the presence of spherical shaped nanoparticle sized between 65 and 94.5 nm. The presence of bioactive functional groups of N-H, C-H and C=0 stretching was identified using Fourier Transform Infrared spectroscopy (FTIR). The maximum mean zone of inhibition obtained was 10.45±0.25 mm for fungi <em>A. niger</em>. The antioxidant activity using DPPH scavenging assay and hydrogen peroxide scavenging assay showed the IC<sub>50</sub> value 33.94 μg/ml and 42.54 μg/ml respectively.</div></div><div><h3>Conclusions</h3><div>The obtained results reveal the potential of CuO-NPs synthesised from <em>I. quamoclit</em> L. as a remarkable medicinal entity for wound healing, respiratory infection, fungal infection and urinary tract infection along with the improved antimicrobial and antioxidant activity.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100940"},"PeriodicalIF":2.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142419120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shenmai injection in treating chemotherapy-related cardiotoxicity of breast cancer: a systematic review and meta-analysis 神麦注射液治疗乳腺癌化疗相关心脏毒性：系统综述和荟萃分析

IF 2.2 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2024-09-17 DOI: 10.1016/j.hermed.2024.100936

Ming Feng , Hong Huang , Chang Yao

Objective

Shenmai injection (SMI) is an established treatment for cardiac diseases, and we performed to evaluate the efficacy of SMI combined with chemotherapy drugs for the treatment of chemotherapy-induced cardiotoxicity.

Methods

The primary outcome was abnormal electrocardiogram (ECG), left ventricular ejection fraction (LVEF) and E/A. The secondary outcomes included myocardial injury biomarkers (creatine kinase [CK], creatine kinase MB [CK-MB], and cardiac troponin I [cTnI]) and lipid peroxide markers (superoxide dismutase [SOD], glutathione [GSH], and malondialdehyde [MAD]).

Results

Studies indicated that SMI combined with chemotherapy drugs has advantages over chemotherapy drugs alone in reducing the incidence of abnormal ECG (ST-T: RR = 0.613, 95% CI [0.437, 0.862], P = 0.005; extrasystole: RR = 0.527, 95% CI [0.349, 0.798], P = 0.002). Myocardial injury biomarkers in the experimental group were lower than those in the control group (CK: SMD = –2.614, 95% CI [–3.156, –2.071], P = 0.000; CK-MB: SMD = –6.882, 95% CI [–8.982, –4.782], P = 0.000; cTnI: SMD = –3.610, 95% CI [–4.949, –2.271], P = 0.000). Ultrasonic cardiogram analysis showed that the experimental group had a higher LVEF and E/A than the control group (LVEF: SMD = 1.572, 95% CI [1.176, 1.969], P = 0.000; E/A: SMD = 0.280, 95% CI [0.153, 0.407], P = 0.000). Lipid peroxide meta-analysis showed that the experimental group had higher SOD and GSH levels (SOD: weighted mean difference (WMD) = 39.783, 95% CI (32.524, 47.042), P = 0.000; GSH: WMD = 32.960, 95% CI [26.055, 39.865], P = 0.000), and lower malondialdehyde (MDA) (WMD = –4.962, 95% CI [–6.041, –3.883], P = 0.000).

Conclusion

SMI is effective in reducing cardiac injury and the incidence of cardiotoxicity.

方法主要结果是心电图（ECG）异常、左室射血分数（LVEF）和E/A。次要结果包括心肌损伤生物标志物（肌酸激酶[CK]、肌酸激酶MB[CK-MB]和心肌肌钙蛋白I[cTnI]）和过氧化脂质标志物（超氧化物歧化酶[SOD]、谷胱甘肽[GSH]和丙二醛[MAD]）。结果研究表明，SMI联合化疗药物在降低异常心电图（ST-T：RR=0.613，95% CI [0.437，0.862]，P=0.005；期外收缩：RR=0.527，95% CI [0.349，0.798]，P=0.002）。实验组心肌损伤生物标志物低于对照组（CK：SMD = -2.614，95% CI [-3.156，-2.071]，P = 0.000；CK-MB：SMD = -6.882，95% CI [-8.982，-4.782]，P = 0.000；cTnI：SMD = -3.610，95% CI [-4.949，-2.271]，P = 0.000）。超声心动图分析显示，实验组的 LVEF 和 E/A 均高于对照组（LVEF：SMD=1.572，95% CI [1.176，1.969]，P=0.000；E/A：SMD=0.280，95% CI [0.153，0.407]，P=0.000）。过氧化脂质荟萃分析表明，实验组的 SOD 和 GSH 水平更高（SOD：加权平均差（WMD）= 39.783，95% CI [32.524，47.042]，P = 0.000；GSH：WMD = 32.960，95% CI [26.结论SMI能有效降低心脏损伤和心脏毒性的发生率。

{"title":"Shenmai injection in treating chemotherapy-related cardiotoxicity of breast cancer: a systematic review and meta-analysis","authors":"Ming Feng , Hong Huang , Chang Yao","doi":"10.1016/j.hermed.2024.100936","DOIUrl":"10.1016/j.hermed.2024.100936","url":null,"abstract":"<div><h3>Objective</h3><div>Shenmai injection (SMI) is an established treatment for cardiac diseases, and we performed to evaluate the efficacy of SMI combined with chemotherapy drugs for the treatment of chemotherapy-induced cardiotoxicity.</div></div><div><h3>Methods</h3><div>The primary outcome was abnormal electrocardiogram (ECG), left ventricular ejection fraction (LVEF) and E/A. The secondary outcomes included myocardial injury biomarkers (creatine kinase [CK], creatine kinase MB [CK-MB], and cardiac troponin I [cTnI]) and lipid peroxide markers (superoxide dismutase [SOD], glutathione [GSH], and malondialdehyde [MAD]).</div></div><div><h3>Results</h3><div>Studies indicated that SMI combined with chemotherapy drugs has advantages over chemotherapy drugs alone in reducing the incidence of abnormal ECG (ST-T: RR = 0.613, 95% CI [0.437, 0.862], <em>P</em> = 0.005; extrasystole: RR = 0.527, 95% CI [0.349, 0.798], <em>P</em> = 0.002). Myocardial injury biomarkers in the experimental group were lower than those in the control group (CK: SMD = –2.614, 95% CI [–3.156, –2.071], <em>P</em> = 0.000; CK-MB: SMD = –6.882, 95% CI [–8.982, –4.782], <em>P</em> = 0.000; cTnI: SMD = –3.610, 95% CI [–4.949, –2.271], <em>P</em> = 0.000). Ultrasonic cardiogram analysis showed that the experimental group had a higher LVEF and E/A than the control group (LVEF: SMD = 1.572, 95% CI [1.176, 1.969], <em>P</em> = 0.000; E/A: SMD = 0.280, 95% CI [0.153, 0.407], <em>P</em> = 0.000). Lipid peroxide meta-analysis showed that the experimental group had higher SOD and GSH levels (SOD: weighted mean difference (WMD) = 39.783, 95% CI (32.524, 47.042), <em>P</em> = 0.000; GSH: WMD = 32.960, 95% CI [26.055, 39.865], <em>P</em> = 0.000), and lower malondialdehyde (MDA) (WMD = –4.962, 95% CI [–6.041, –3.883], <em>P</em> = 0.000).</div></div><div><h3>Conclusion</h3><div>SMI is effective in reducing cardiac injury and the incidence of cardiotoxicity.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100936"},"PeriodicalIF":2.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0