Journal of Herbal Medicine最新文献_第3页

Saffron and immune regulation: influence on inflammatory biomarkers and gene expression in rheumatoid arthritis 藏红花与免疫调节：对类风湿关节炎炎症生物标志物和基因表达的影响

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-10-15 DOI: 10.1016/j.hermed.2025.101065

Mahsa Hadidi , Naheed Aryaeian , Mahdi Mahmoudi , Jamileh Abolghasemi , Zahra Hamidi , Mehrnaz Morvaridi , Masoumeh Akhlaghi

Introduction

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterised by persistent joint inflammation and progressive damage, largely mediated by pro-inflammatory cytokines. Saffron (Crocus sativus), a medicinal plant rich in bioactive compounds, has shown anti-inflammatory and immunomodulatory properties in preclinical studies. This trial aimed to evaluate the effects of saffron supplementation on inflammatory markers and immune-related gene expression in patients with active RA.

Methods

In this randomised, double-blind, placebo-controlled trial, 72 adult patients aged 18–65 years with active RA were assigned to receive either 100 mg/d of saffron powder (n = 36) or a matched placebo (n = 36) for 12 weeks. Clinical assessments, cytokine measurements (IL-17, IL-4), and quantitative gene expression analyses (FoxP3, RORγt, NF-κB, T-bet) were conducted at baseline and post-intervention.

Results

Saffron supplementation significantly reduced Patient Global Assessment (PGA) scores (P < 0.001) and IL-17 levels (P = 0.002) compared to placebo, while IL-4 levels remained unchanged (P = 0.610). Gene expression analysis revealed a significant upregulation of FoxP3 and downregulation of RORγt, NF-κB, and T-bet in the saffron group (P < 0.05).

Conclusion

Saffron supplementation may offer therapeutic benefits in RA by modulating key inflammatory pathways and enhancing regulatory immune responses. These findings support the potential of saffron as a complementary approach in RA management. Further studies are warranted to validate these results and elucidate underlying mechanisms.

Trial registration

IRCT, IRCT201707309472N15. Registered October 15, 2017, https://irct.behdasht.gov.ir/trial/10062.

类风湿性关节炎（RA）是一种慢性自身免疫性疾病，其特征是持续的关节炎症和进行性损伤，主要由促炎细胞因子介导。藏红花（Crocus sativus）是一种富含生物活性化合物的药用植物，在临床前研究中显示出抗炎和免疫调节的特性。本试验旨在评估补充藏红花对活动性RA患者炎症标志物和免疫相关基因表达的影响。在这项随机、双盲、安慰剂对照试验中，72名18-65岁的活动性RA成年患者被分配接受100 mg/d的藏红花粉（n = 36）或匹配的安慰剂（n = 36），为期12周。在基线和干预后进行临床评估、细胞因子测量（IL-17、IL-4）和定量基因表达分析（FoxP3、RORγt、NF-κB、T-bet）。结果与安慰剂相比，补充affron显著降低了患者总体评估（PGA）评分（P < 0.001）和IL-17水平（P = 0.002），而IL-4水平保持不变（P = 0.610）。基因表达分析显示，藏红花组FoxP3显著上调，rorγ - t、NF-κB、T-bet下调（P < 0.05）。结论补充藏红花可能通过调节关键的炎症通路和增强调节性免疫反应来治疗RA。这些发现支持藏红花作为RA管理的补充方法的潜力。需要进一步的研究来验证这些结果并阐明潜在的机制。试验注册号：irct， IRCT201707309472N15。2017年10月15日注册，https://irct.behdasht.gov.ir/trial/10062。

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引用次数: 0

GC-MS based comparative phytochemical profiling with anti-acne and antidermatophytic activities of commercial and organic tea tree oils 基于GC-MS的商业茶树油和有机茶树油抗痤疮和抗皮肤真菌活性的比较植物化学分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-10-14 DOI: 10.1016/j.hermed.2025.101064

Sultan Pekacar , Imge Ece Göçmen İlhan , Mine Kürkçüoğlu , Berrin Özçelik , Didem Deliorman Orhan

Introduction

Tea tree oil (TTO), mainly derived from Melaleuca alternifolia, is widely used in herbal medicine for its antimicrobial effects, particularly in treating acne and dermatophytic infections. With increasing clinical use, ensuring TTO quality is essential for efficacy and safety. This study aimed to evaluate the quality and antimicrobial, anti-acne, and antidermatophytic activities of commercially available TTO.

Methods

Twelve commercial TTO obtained from pharmacies, herbal stores, and health product retailers, along with one organic pure TTO reference, were analyzed following the European Pharmacopoeia 8.0 monograph criteria. Quality assessments included visual inspection, solubility and staining tests, thin-layer chromatography, and gas chromatography-mass spectrometry (GC-MS). Antimicrobial activities were tested against Cutibacterium acnes ATCC 6919 and dermatophyte strains Trichophyton rubrum RSKK 486, Epidermophyton floccosum RSKK 3027, and Microsporum gypseum NCPF 580 using standard microbiological methods.

Results

Only the organic TTO complied with the compositional requirements of the European Pharmacopoeia (EP) monograph, based on GC-MS analysis. Commercial samples showed significant deviations in chemical composition and physicochemical properties, exhibiting markedly lower antimicrobial and antidermatophytic activities compared to the organic reference.

Conclusion

This study shows only the organic TTO fulfilled ISO standards and EP compositional requirements, with notably higher antimicrobial activity against dermatophytes and C. acnes. These findings reveal concerns about the quality and potential adulteration of commercial TTO products. Ensuring product authenticity and adherence to standards is critical for their safe and effective use in managing acne and dermatophytosis. Strengthened quality control and regulatory measures are necessary to protect public health and support therapeutic applications.

茶树油（TTO）主要来源于互花千层树，因其抗菌作用而被广泛用于草药中，特别是治疗痤疮和皮肤真菌感染。随着临床应用的增加，确保TTO质量对疗效和安全性至关重要。本研究旨在评价市售白托的质量及其抗菌、抗痤疮和抗皮肤真菌活性。方法采用欧洲药典8.0专著标准，对从药店、草药商店和保健品零售商处获得的12种市售TTO及1种有机纯TTO对照品进行分析。质量评估包括目视检查、溶解度和染色试验、薄层色谱和气相色谱-质谱（GC-MS）。采用标准微生物学方法对痤疮角质杆菌ATCC 6919、红毛癣菌RSKK 486、絮状表皮菌RSKK 3027、石膏小孢子菌NCPF 580进行抑菌活性测定。结果经气相色谱-质谱分析，只有有机TTO符合欧洲药典（EP）各论的成分要求。商业样品在化学成分和理化性质上表现出明显的差异，与有机参比相比，抗菌和抗皮肤病活性明显较低。结论有机TTO符合ISO标准和EP成分要求，对皮肤癣菌和痤疮菌具有较高的抑菌活性。这些发现揭示了对商业TTO产品的质量和潜在掺假的担忧。确保产品的真实性和遵守标准是至关重要的，他们的安全和有效的使用管理痤疮和皮肤癣。必须加强质量控制和监管措施，以保护公众健康和支持治疗应用。

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引用次数: 0

Phytochemical constituents, and antioxidant, antidiabetic and anti-inflammatory activities of the extracts from Pandanus amaryllifolius Roxb. 香豆提取物的植物化学成分及抗氧化、抗糖尿病和抗炎活性研究。

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-25 DOI: 10.1016/j.hermed.2025.101062

Nopparat Buddhakala , Butsara Yongkhamcha

Introduction

This study was aimed to determine phytochemical constituents, and antioxidant, antidiabetic and anti-inflammatory activities of the leaf extracts from Pandanus amaryllifolius and verify whether extracting solvents and concentrations, and age of leaves influence phytochemicals and activities of the extracts.

Methods

Mature leaves were extracted with 50% or 95% ethanol. Young, medium, and mature leaves were extracted with 80 °C or 100 °C distilled water. Liquid Chromatography-Mass Spectroscopy (LC-MS) and phytochemical screening, evaluation of total phenolic content (TPC) and total flavonoid content (TFC) along with 2,2-diphenyl-1-picrylhydrazyl (radical scavenging assay) (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (radical cation assay) (ABTS) and ferric reducing antioxidant power (FRAP) assays, α-glucosidase and α-amylase assays, and Griess assay were employed for determination of phytochemical constituents, antioxidant, antidiabetic and anti-inflammatory activities, respectively.

Results

LC-MS analysis revealed 61 compounds in 50% ethanol extract and 94 compounds in the 95% ethanol extract. Quercetin 3-galactoside was the most predominant compound in the 50% ethanol extract, and saponarin in the 95% ethanol extract. The 95% ethanol extract possessed higher antioxidant, antidiabetic and anti-inflammatory activities than the 50% ethanol extract. The water extracts contained phenolics, flavonoids, terpenoids, and saponins. The mature leaves extracted with 80 °C water exhibited the highest antidiabetic activity, in comparing to others.

Conclusions

The extracting solvents and concentrations as well as the leaf ages significantly influence the phytochemical constituents and the antioxidant, antidiabetic and anti-inflammatory activities of the extracts. The findings support the potential development of P. amaryllifolius extracts as functional ingredients for managing diseases related to oxidative stress, diabetes, and inflammation.

本研究旨在测定香豆叶提取物的植物化学成分、抗氧化、抗糖尿病和抗炎活性，并验证提取溶剂、提取浓度和叶龄对其植物化学成分和活性的影响。方法用50%或95%乙醇提取成熟叶。幼叶、中叶和成熟叶分别用80°C或100°C的蒸馏水提取。采用液相色谱-质谱（LC-MS）和植物化学筛选，评价总酚含量（TPC）和总黄酮含量（TFC），并采用2,2-二苯基-1-picrylhydrazyl（自由基清除试验）（DPPH）、2,2 ' -氮基-双（3-乙基苯并噻唑-6-磺酸）（自由基阳离子试验）（ABTS）和铁还原抗氧化能力（FRAP）试验、α-葡萄糖苷酶和α-淀粉酶试验以及Griess试验测定植物化学成分、抗氧化剂、分别具有抗糖尿病和抗炎活性。结果从50%乙醇提取物中分离出61种化合物，从95%乙醇提取物中分离出94种化合物。槲皮素3-半乳糖苷在50%乙醇提取物中含量最高，皂苷在95%乙醇提取物中含量最高。95%乙醇提取物比50%乙醇提取物具有更高的抗氧化、抗糖尿病和抗炎活性。水提取物含有酚类、黄酮类、萜类和皂苷。80°C水浸提的成熟叶抗糖尿病活性最高。结论提取溶剂、提取浓度、叶龄对黄芪提取物的化学成分及抗氧化、抗糖尿病、抗炎活性均有显著影响。这些发现支持了amaryllifolius提取物作为治疗氧化应激、糖尿病和炎症相关疾病的功能成分的潜在开发。

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引用次数: 0

Investigation of the action mechanism of Madhumega kudineer formulation against diabetic nephropathy by network pharmacology, molecular docking and dynamics strategies 从网络药理学、分子对接和动力学等方面探讨苦参素制剂对糖尿病肾病的作用机制

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-22 DOI: 10.1016/j.hermed.2025.101061

Bhuvana K. , Revathy Praba L. , Jayanth Jeevanandam , Esackimuthu P. , Srikanth Raghavendran , Saraswathi N.T.

Introduction

Diabetic nephropathy (DN), a microvascular complication of diabetes leads to chronic kidney disease and end stage kidney disease. In this study, we aim to elucidate the major pathways and key targets involved in the therapeutic effect of Madhumega kudineer (MK-polyherbal formulation), used in the treatment of DN by network pharmacology.

Methods

The common gene-targets corresponding to MK-phytochemicals and DN were used for phytochemical-target network construction, gene-ontology enrichment, KEGG pathway enrichment and protein–protein interaction (PPI) network. The major cellular pathways and the key-targets involved were further identified by KEGG enrichment. The interaction of identified key-targets with phytochemicals was investigated by in silico methods of molecular docking, molecular dynamics simulation and MM-PBSA.

Results

From the PPI network of common gene-targets, 23 core-targets with degree above mean (>83) were shortlisted and their KEGG pathway enrichment revealed AGE-RAGE complications, TNF signalling and IL-17 signalling to be the top pathways. From the cross-section of the above pathways, the key-targets identified includes AKT1, TNF-α and IL6. Based on the highest binding affinity, the key-target and the corresponding MK-phytochemical complex were AKT1-quercetin, TNF-α-andrographolide and IL6-andrographolide. Molecular dynamic simulations evaluated the conformational stability of these complexes. MM-PBSA binding energy calculations revealed that van der Waals interactions predominantly drive the binding of MK phytochemicals to AKT1, TNF-α and IL6, with energy contributions from the hydrophobic residues in their binding regions.

Conclusion

Our in-silico analysis suggests that the phytochemicals of Madhumega kudineer combats diabetic nephropathy by targeting AKT1, TNF-α and IL6 involved in inflammatory pathways.

糖尿病肾病（DN）是糖尿病的微血管并发症，可导致慢性肾脏疾病和终末期肾脏疾病。在本研究中，我们旨在通过网络药理学阐明Madhumega kudineer （mk -多草药制剂）治疗DN的主要通路和关键靶点。方法利用mk -植物化学物质和DN对应的共同基因靶点构建植物化学靶点网络、基因本体富集、KEGG通路富集和蛋白-蛋白相互作用（PPI）网络。通过KEGG富集进一步鉴定了主要的细胞通路和涉及的关键靶点。采用分子对接、分子动力学模拟和MM-PBSA等方法研究了鉴定出的关键靶点与植物化学物质的相互作用。结果从常见基因靶点的PPI网络中，筛选出23个程度高于平均值的核心靶点（>83），其KEGG通路富集显示AGE-RAGE并发症、TNF信号和IL-17信号是最重要的通路。从上述途径的横截面来看，鉴定出的关键靶点包括AKT1、TNF-α和il - 6。基于最高的结合亲和力，关键靶点和相应的mk -植物化学复合物是akt1 -槲皮素、TNF-α-穿心莲内酯和il6 -穿心莲内酯。分子动力学模拟评价了这些配合物的构象稳定性。MM-PBSA结合能计算显示，van der Waals相互作用主要驱动MK植物化学物质与AKT1、TNF-α和il - 6的结合，其结合区域的疏水残基提供能量。结论我们的计算机分析表明，Madhumega kudineer的植物化学物质通过靶向参与炎症通路的AKT1、TNF-α和il - 6来对抗糖尿病肾病。

{"title":"Investigation of the action mechanism of Madhumega kudineer formulation against diabetic nephropathy by network pharmacology, molecular docking and dynamics strategies","authors":"Bhuvana K. , Revathy Praba L. , Jayanth Jeevanandam , Esackimuthu P. , Srikanth Raghavendran , Saraswathi N.T.","doi":"10.1016/j.hermed.2025.101061","DOIUrl":"10.1016/j.hermed.2025.101061","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetic nephropathy (DN), a microvascular complication of diabetes leads to chronic kidney disease and end stage kidney disease. In this study, we aim to elucidate the major pathways and key targets involved in the therapeutic effect of Madhumega kudineer (MK-polyherbal formulation), used in the treatment of DN by network pharmacology.</div></div><div><h3>Methods</h3><div>The common gene-targets corresponding to MK-phytochemicals and DN were used for phytochemical-target network construction, gene-ontology enrichment, KEGG pathway enrichment and protein–protein interaction (PPI) network. The major cellular pathways and the key-targets involved were further identified by KEGG enrichment. The interaction of identified key-targets with phytochemicals was investigated by <em>in silico</em> methods of molecular docking, molecular dynamics simulation and MM-PBSA.</div></div><div><h3>Results</h3><div>From the PPI network of common gene-targets, 23 core-targets with degree above mean (>83) were shortlisted and their KEGG pathway enrichment revealed AGE-RAGE complications, TNF signalling and IL-17 signalling to be the top pathways. From the cross-section of the above pathways, the key-targets identified includes AKT1, TNF-α and IL6. Based on the highest binding affinity, the key-target and the corresponding MK-phytochemical complex were AKT1-quercetin, TNF-α-andrographolide and IL6-andrographolide. Molecular dynamic simulations evaluated the conformational stability of these complexes. MM-PBSA binding energy calculations revealed that van der Waals interactions predominantly drive the binding of MK phytochemicals to AKT1, TNF-α and IL6, with energy contributions from the hydrophobic residues in their binding regions.</div></div><div><h3>Conclusion</h3><div>Our <em>in-silico</em> analysis suggests that the phytochemicals of Madhumega kudineer combats diabetic nephropathy by targeting AKT1, TNF-α and IL6 involved in inflammatory pathways.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"54 ","pages":"Article 101061"},"PeriodicalIF":1.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial and antifungal effect of Salvadora persica L. root extract, essential oil, and nanoemulsion 木香根提取物、精油和纳米乳的抑菌抑菌作用

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-19 DOI: 10.1016/j.hermed.2025.101058

Mehrdad Yazdi , Javad Akhtari , Ali Davoodi , Iman Haghani , Zahra Kiadehi , Hamid Reza Goli

Introduction

Due to increasing antimicrobial resistance rates, this study aimed to evaluate the antibacterial and antifungal effect of the alcoholic extract, essential oil, and nanoemulsion prepared from Salvadora persica L. root.

Methods

Alcoholic extract of S. persica root and its essential oil were prepared by percolation and distillation methods, respectively. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) of the antimicrobials were determined against clinically significant bacteria and fungi.

Results

The alcoholic extract with a concentration of 6.25% inhibited Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Meanwhile, the essential oil had a better inhibitory effect on Staphylococcus aureus, Enterococcus faecalis, and Streptococcus mutans. Also, nanoemulsion was able to inhibit most Gram-negative bacteria (0.09%). The minimum bactericidal concentration of the extract was not appropriate, but the essential oil was able to kill the tested Gram-positive bacteria (12.5%). Also, nanoemulsion was able to kill Gram-negative bacteria (0.39%), except P. aeruginosa. Candida albicans and Aspergillus fumigatus were the most sensitive fungi to root extract, while the essential oil was able to inhibit all fungi (1.56%). Nanoemulsion was also able to inhibit all fungi (0.09%), except Aspergillus niger. In addition, the antifungal compounds showed a low minimum fungicidal concentration.

Conclusion

The nanoemulsion prepared from the S. persica root had more pronounced antibacterial and antifungal effects than the alcoholic extract and essential oil. However, these agents may be effective as adjuvants in the prevention or treatment of infections.

摘要：由于鼠尾草根的耐药率越来越高，本研究旨在评价鼠尾草根酒精提取物、精油和纳米乳的抗菌和抗真菌作用。方法采用浸透法和蒸馏法分别制备茴香根乙醇提取物和挥发油。测定抗菌药物对临床重要细菌和真菌的最小抑菌浓度（MIC）、最小杀菌浓度（MBC）和最小杀真菌浓度（MFC）。结果6.25%浓度的醇提物对铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌、变形杆菌均有抑制作用。同时，精油对金黄色葡萄球菌、粪肠球菌、变形链球菌均有较好的抑制作用。纳米乳对革兰氏阴性菌的抑制率为0.09%。精油对革兰氏阳性菌（12.5%）有一定的杀灭作用。除铜绿假单胞菌外，纳米乳对革兰氏阴性菌（0.39%）均有杀伤作用。根提取物对白色念珠菌和烟曲霉最敏感，对所有真菌均有抑制作用（1.56%）。纳米乳对除黑曲霉外的所有真菌均有抑制作用（0.09%）。此外，抗真菌化合物表现出较低的最低杀真菌浓度。结论木香根纳米乳的抑菌抑菌作用明显优于醇提物和挥发油。然而，这些药物在预防或治疗感染时可能作为佐剂有效。

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引用次数: 0

Ayurvedic management of adverse effects of antitubercular treatment: a case report 阿育吠陀治疗抗结核治疗不良反应1例报告

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-18 DOI: 10.1016/j.hermed.2025.101060

Amit Nakanekar , Yogita Pole , Payal Rathod , Shivray Amrit Patil , Manjiri Palnitkar

Background

Tuberculosis is a worldwide public health problem. Antitubercular regimens are widely used against it; however, antitubercular Therapy causes various adverse effects. Primarily, pyrazinamide and ethambutol cause Hyperuricemia, and uricosuric medicines are used to manage it, but they also have many adverse effects. This case report highlights the importance of Ayurvedic treatment in managing Hyperuricemia induced by antitubercular treatment.

Case presentation

A 24-year-old female patient with a known case of pulmonary tuberculosis on antitubercular treatment came for a follow-up of Antitubercular Therapy with complaints of bilateral shoulder joint pain, B/L Ankle joint pain, elbow joint pain, non-pitting edema over Ankle joint (Lt > Rt) and shoulder joint, difficulty in walking, redness over Ankle region, weakness, loss of appetite, burning sensation since 1–2 weeks. The patient was managed with oral Ayurvedic medicines and five sessions of Siravedha (∼Therapeutic bloodletting) without stopping conventional antitubercular treatment. The progressive improvement in Hyperuricemia induced by antitubercular Therapy was observed, with reduced swelling of joints, joint pain, and burning sensation. Uric acid was lowered from 8 to 3.1 mg/dl in 30 days.

Conclusion

This case study focuses on the effect of the Ayurvedic treatment approach on controlling the adverse impacts of antitubercular Therapy. The role of Ayurveda in the management of adverse effects of antitubercular drugs (ATDs) is sporadic and primarily limited. As a worldwide public health crisis, it is highly recommended to carry out further clinical trials on Tuberculosis patients using Ayurvedic drugs and therapeutic regimens.

结核病是一个全球性的公共卫生问题。抗结核药物被广泛用于治疗结核病；然而，抗结核治疗引起各种不良反应。首先，吡嗪酰胺和乙胺丁醇引起高尿酸血症，尿毒学药物用于控制它，但它们也有许多副作用。本病例报告强调了阿育吠陀治疗在管理抗结核治疗引起的高尿酸血症中的重要性。1例24岁女性患者，已知结核结核患者，接受抗结核治疗，自1-2周以来，主诉双侧肩关节疼痛，B/L踝关节疼痛，肘关节疼痛，踝关节（Lt > Rt）及肩关节非麻点性水肿，行走困难，踝关节区域发红，虚弱，食欲不振，灼烧感。患者在不停止常规抗结核治疗的情况下接受口服阿育吠陀药物和5次Siravedha（治疗性放血）治疗。观察到抗结核治疗引起的高尿酸血症的进行性改善，关节肿胀，关节疼痛和烧灼感减轻。尿酸在30天内从8 mg/dl降至3.1 mg/dl。结论本案例研究的重点是阿育吠陀治疗方法对控制抗结核治疗不良反应的作用。阿育吠陀在抗结核药物（ATDs）不良反应管理中的作用是零星的，主要是有限的。作为一个全球性的公共卫生危机，强烈建议对使用阿育吠陀药物和治疗方案的结核病患者进行进一步的临床试验。

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引用次数: 0

Efficacy and safety of traditional Chinese medicine for post-infectious cough compared to placebo: a systematic review and meta-analysis 与安慰剂相比，中药治疗感染性咳嗽的疗效和安全性：一项系统综述和荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-18 DOI: 10.1016/j.hermed.2025.101059

Xinyi Zhang , Xin Jin , Jianning Guo , Hongchun Zhang

Introduction

Post-infectious cough (PIC) is a common form of cough with a high incidence rate, accounting for approximately 48.4% of subacute cough cases. Currently, there is no conclusive evidence indicating that pharmacological treatments exert a significant therapeutic effect on PIC, and standardised treatment protocols have yet to be established. This study aims to evaluate the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of PIC, providing a reference for clinical practice.

Methods

A comprehensive search was conducted across multiple databases. Randomised controlled trials (RCTs) investigating TCM interventions for PIC were retrieved, with the search covering all publications up to February 6, 2025. Risk of bias was assessed using the Cochrane Risk of Bias tool and meta-analysis was conducted using RevMan 5.4 software.

Results

A total of nine articles were included, comprising seven RCTs. The meta-analysis demonstrated that TCM was significantly more effective than placebo in reducing cough symptom scores, alleviating cough severity, lowering TCM syndrome scores, improving cough relief rate and resolution rate, and enhancing clinical efficacy rate. Moreover, no serious adverse events were reported. TCM may also contribute to shortening the time to cough relief and resolution. However, no statistically significant differences were observed in terms of quality of life improvement or recurrence rates of cough.

Conclusion

Compared with placebo, TCM treatment for PIC demonstrates superior clinical efficacy, improving cough symptoms and shortening the disease course, with good safety profiles.

感染后咳嗽（PIC）是一种常见的咳嗽形式，发病率高，约占亚急性咳嗽病例的48.4%。目前，没有确凿的证据表明药物治疗对PIC有显著的治疗效果，标准化的治疗方案尚未建立。本研究旨在评价中药治疗PIC的疗效和安全性，为临床实践提供参考。方法在多个数据库中进行综合检索。检索调查中药干预PIC的随机对照试验（RCTs），检索涵盖截至2025年2月6日的所有出版物。采用Cochrane风险偏倚工具评估偏倚风险，采用RevMan 5.4软件进行meta分析。结果共纳入9篇文章，包括7篇rct。meta分析显示，中药在降低咳嗽症状评分、减轻咳嗽严重程度、降低中医证候评分、提高咳嗽缓解率和治愈率、提高临床有效率等方面均显著优于安慰剂。此外，没有严重不良事件的报道。中医也有助于缩短咳嗽缓解和消退的时间。然而，在生活质量改善和咳嗽复发率方面，没有观察到统计学上的显著差异。结论中药治疗PIC临床疗效优于安慰剂，可改善咳嗽症状，缩短病程，且安全性较好。

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引用次数: 0

Cocrystal of flavonoids as potential phyto-therapeutic agents against SARS-CoV-2: a scoping review 类黄酮共晶作为抗SARS-CoV-2的潜在植物治疗剂：范围综述

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-18 DOI: 10.1016/j.hermed.2025.101057

Bonta Ramesh Kumar, Kottur Mohan Kumar, Saikat Sen, Srinivas Oruganti

Background

Natural products have gained popularity over the last two decades due to their remarkable pharmacological properties, which include anti-cancer, antiviral, anti-inflammatory, and antibacterial effects. These characteristics make them naturally existing potential candidates for the creation of novel medications. Flavonoids, a well-known family of secondary metabolites, have shown antiviral efficacy against SARS-CoV-2. Since these natural bioactives have a low solubility in aqueous medium, their bioavailability studies are however severely impeded.

Objective

The study focuses on the co-crystallisation process, a cutting-edge and promising strategy for enhancing the bioavailability of weakly water-soluble pharmaceuticals, such as flavonoids. The review examines flavonoids, their function against SARS-CoV-2, and their antiviral potential, as well as cocrystals, recent cocrystal production methods, flavonoid cocrystals developed to date, and the possibilities of developing flavonoid cocrystals to combat SARS-CoV-2 infection.

Methods

PubMed, Scopus database, Web of Science, and Google Scholar were accessed for the literature search. The data was compiled based on the abstract, titles, and relevance of work.

Results

The expository review of the literature indicated that numerous cocrystals of flavonoids have been developed to address challenges related to their bioavailability. These developed cocrystals have better physicochemical features and pharmacological activity.

Conclusion

Cocrystals containing antiviral flavonoids may be a promising strategy for treating viral illnesses, with a high success rate as observed in preliminary studies. The authors believe that by producing flavonoid cocrystals utilising innovative techniques, flavonoid solubility and absorption rates can be improved.

在过去的二十年中，天然产品因其显著的药理特性而受到欢迎，包括抗癌、抗病毒、抗炎和抗菌作用。这些特征使它们自然成为创造新型药物的潜在候选者。类黄酮是一种众所周知的次生代谢物家族，已显示出对SARS-CoV-2的抗病毒作用。由于这些天然生物活性物质在水介质中的溶解度较低，因此它们的生物利用度研究受到严重阻碍。目的研究提高弱水溶性药物（如黄酮类化合物）生物利用度的一种前沿和有前途的共结晶方法。本文综述了类黄酮及其抗SARS-CoV-2的功能和抗病毒潜力，以及共晶、最近的共晶生产方法、迄今为止开发的类黄酮共晶，以及开发抗SARS-CoV-2感染的类黄酮共晶的可能性。方法使用spubmed、Scopus数据库、Web of Science和谷歌Scholar进行文献检索。数据是根据论文摘要、标题和相关性进行整理的。结果通过对相关文献的综述，发现了大量的类黄酮共晶，以解决其生物利用度方面的问题。这些发育的共晶具有较好的理化特性和药理活性。结论含有抗病毒类黄酮的共晶可能是治疗病毒性疾病的一种有前景的策略，初步研究表明其成功率较高。作者认为，利用创新技术制备类黄酮共晶可以提高类黄酮的溶解度和吸收率。

{"title":"Cocrystal of flavonoids as potential phyto-therapeutic agents against SARS-CoV-2: a scoping review","authors":"Bonta Ramesh Kumar, Kottur Mohan Kumar, Saikat Sen, Srinivas Oruganti","doi":"10.1016/j.hermed.2025.101057","DOIUrl":"10.1016/j.hermed.2025.101057","url":null,"abstract":"<div><h3>Background</h3><div>Natural products have gained popularity over the last two decades due to their remarkable pharmacological properties, which include anti-cancer, antiviral, anti-inflammatory, and antibacterial effects. These characteristics make them naturally existing potential candidates for the creation of novel medications. Flavonoids, a well-known family of secondary metabolites, have shown antiviral efficacy against SARS-CoV-2. Since these natural bioactives have a low solubility in aqueous medium, their bioavailability studies are however severely impeded.</div></div><div><h3>Objective</h3><div>The study focuses on the co-crystallisation process, a cutting-edge and promising strategy for enhancing the bioavailability of weakly water-soluble pharmaceuticals, such as flavonoids. The review examines flavonoids, their function against SARS-CoV-2, and their antiviral potential, as well as cocrystals, recent cocrystal production methods, flavonoid cocrystals developed to date, and the possibilities of developing flavonoid cocrystals to combat SARS-CoV-2 infection.</div></div><div><h3>Methods</h3><div>PubMed, Scopus database, Web of Science, and Google Scholar were accessed for the literature search. The data was compiled based on the abstract, titles, and relevance of work.</div></div><div><h3>Results</h3><div>The expository review of the literature indicated that numerous cocrystals of flavonoids have been developed to address challenges related to their bioavailability. These developed cocrystals have better physicochemical features and pharmacological activity.</div></div><div><h3>Conclusion</h3><div>Cocrystals containing antiviral flavonoids may be a promising strategy for treating viral illnesses, with a high success rate as observed in preliminary studies. The authors believe that by producing flavonoid cocrystals utilising innovative techniques, flavonoid solubility and absorption rates can be improved.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"54 ","pages":"Article 101057"},"PeriodicalIF":1.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of aromatherapy for reducing nausea and vomiting of pregnancy: a systematic review and meta-analysis 芳香疗法减轻妊娠期恶心呕吐的疗效：一项系统综述和荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-17 DOI: 10.1016/j.hermed.2025.101056

Farzaneh Safajou , Marzieh Bagherinia , Kowsar Qaderi , Arezoo Haseli , Fereshteh Yazdani , Mohaddese Mortezapoor

Background

Nausea and vomiting of pregnancy (NVP) affect pregnant women's quality of life. Despite the availability of pharmacological therapeutics, many prefer non-pharmacological methods such as aromatherapy. This study systematically reviews the effectiveness of aromatherapy in reducing NVP.

Method

Articles were searched from the Cochrane Library, ClinicalTrials.gov, SCOPUS, Web of Science, PubMed, Embase, and ProQuest databases without restrictions on language or publication date, up to November 2024. All controlled clinical trials on aromatherapy's effect on reducing NVP were included. A meta-analysis with random-effects reported standardised mean differences (SMD) and 95% confidence intervals. Heterogeneity was assessed with the Cochrane Q test and I² statistic.

Results

Ten studies that met the inclusion criteria were included, and nine were used for meta-analysis. The results showed that aromatherapy significantly reduces the severity of NVP [SMD = −0.65 (95% CI: −1.08 to −0.21) and (I² = 82.78%, P = 0.00)]. Subgroup analysis based on nausea and vomiting assessment instrument, aromatherapy type, and intervention duration showed that used the Rhodes scale to measure NVP, the mean difference between the aromatherapy group and the control group was statistically significant [MD = −4.11 (95% CI: −7.23 to −0.99)]. Lavender aromatherapy had the greatest effect in reducing NVP [SMD = −1.28 (95% CI: −2.45 to −0.11)]. Shorter aromatherapy (3–4 days) was more effective than a 7-day one in reducing NVP. [SMD = −0.73 (95% CI: −1.27 to −0.19)]. No publication bias was indicated (P = 0.576).

Conclusion

This meta-analysis supports the efficacy of aromatherapy as a non-pharmacological method for reducing NVP.

妊娠期恶心呕吐（NVP）影响孕妇的生活质量。尽管有药物治疗方法，但许多人更喜欢非药物方法，如芳香疗法。本研究系统回顾了芳香疗法降低NVP的有效性。方法从Cochrane Library、ClinicalTrials.gov、SCOPUS、Web of Science、PubMed、Embase和ProQuest数据库中检索文章，不受语言和出版日期的限制，截止到2024年11月。所有关于芳香疗法降低NVP效果的对照临床试验均被纳入。随机效应荟萃分析报告了标准化平均差异（SMD）和95%置信区间。采用Cochrane Q检验和I²统计量评估异质性。结果纳入符合纳入标准的10项研究，其中9项用于meta分析。结果显示，芳香疗法可显著降低NVP的严重程度[SMD = - 0.65 （95% CI: - 1.08 ~ - 0.21）和（I2 = 82.78%, P = 0.00）]。基于恶心呕吐评估工具、芳香疗法类型和干预时间的亚组分析显示，使用Rhodes量表测量NVP，芳香疗法组与对照组的平均差异有统计学意义[MD = - 4.11 (95% CI: - 7.23 ~ - 0.99)]。薰衣草芳香疗法在降低NVP方面效果最大[SMD = - 1.28 (95% CI: - 2.45至- 0.11)]。较短的芳香疗法（3-4天）在降低NVP方面比7天更有效。[SMD = - 0.73 (95% CI: - 1.27 ~ - 0.19)]。未发现发表偏倚（P = 0.576）。结论本荟萃分析支持芳香疗法作为一种非药物方法降低NVP的有效性。

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引用次数: 0

Efficacy of combined Chinese and Western medicine in the treatment of hypothyroidism: a systematic review and network meta-analysis 中西医结合治疗甲状腺功能减退的疗效：系统评价和网络荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-09 DOI: 10.1016/j.hermed.2025.101055

Ma Yixuan , Yang Wenhui , Wang Huizhen , Zhai Mingming

Objective

To systematically evaluate combined Chinese and Western medicine for hypothyroidism, provide a reference for clinical treatment, and promote integrative medicine development in hypothyroidism treatment.

Methods

Randomised controlled trials (RCTs) of combined Chinese and Western medicine for the treatment of hypothyroidism were searched from CNKI, WanFang, SinoMed, PubMed, Web of Science, Cochrane Library, etc., from database inception to April 2024. Additionally, Network Meta-analysis was performed using Stata 17.

Results

A total of 59 papers involving 24 Traditional Chinese Medicine (TCM) interventions were included. Zhenqi Fuzheng capsules combined with conventional western medicines had significantly improved the total clinical effectiveness rate and free thyroxine (FT4); Xiaoying decoction combined with conventional western medicines had significantly reduced thyroid-stimulating hormone (TSH); acupuncture combined with conventional western medicines had significantly improved free triiodothyronine (FT3); Jianggui Yiying Prescription combined with Yougui pills combined with conventional western medicines had significantly reduced thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb); Yougui pills combined with conventional western medicines had significantly reduced triglyceride (TG); Zhenwu decoction combined with conventional western medicines had significantly raised high-density lipoprotein cholesterol (HDL-C), reduced total cholesterol (TC)/low-density lipoprotein cholesterol (LDL-C), and lowered TCMSS (Traditional Chinese Medicine Syndrome Score).The incidence rates and types of adverse reactions varied among different intervention measures.

Conclusion

Combined Chinese and Western medicine showed greater efficacy than Western medicine alone for hypothyroidism. Optimal regimens vary by clinical condition, and patients should select treatments accordingly. However, conclusions require further validation due to limited literature quality and quantity.

目的系统评价中西医结合治疗甲状腺功能减退的疗效，为临床治疗提供参考，促进中西医结合治疗甲状腺功能减退的发展。方法检索中国知网、万方、中国医学信息网、PubMed、Web of Science、Cochrane Library等数据库自建库至2024年4月期间中西医结合治疗甲状腺功能减退症的随机对照试验（RCTs）。此外，使用Stata 17进行网络meta分析。结果共纳入59篇文献，涉及24项中医干预措施。贞芪扶正胶囊联合常规西药可显著提高临床总有效率和游离甲状腺素（FT4）；小影汤联合常规西药可显著降低促甲状腺激素（TSH）；针刺联合西药治疗显著提高游离三碘甲状腺原氨酸（FT3）；姜桂益应方联合右桂丸联合常规西药可显著降低甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TGAb）；油桂丸联合常规西药可显著降低甘油三酯（TG）；真武汤联合西药治疗可显著提高高密度脂蛋白胆固醇（HDL-C），降低总胆固醇(TC)/低密度脂蛋白胆固醇（LDL-C），降低中医证候评分（TCMSS）。不同干预措施的不良反应发生率和类型不同。结论中西医结合治疗甲状腺功能减退的疗效优于单用西药。最佳方案因临床情况而异，患者应据此选择治疗方案。然而，由于文献质量和数量有限，结论需要进一步验证。

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引用次数: 0