Journal of Herbal Medicine最新文献

{"title":"Chemical analysis and bioactivity evaluation of Citrus limon leaves volatile oil from Palestine: investigating phytochemical, anti-inflammatory, antimicrobial, and cytotoxic properties","authors":"Nidal Jaradat ,&nbsp;Mohammed Hawash ,&nbsp;Murad Abualhasan ,&nbsp;Nawaf Al-Maharik ,&nbsp;Mohammad Qadi ,&nbsp;Raneen Qabaha ,&nbsp;Khariya Amarneh ,&nbsp;Aya Qabaha ,&nbsp;Sama’ Qassarwi ,&nbsp;Linda Issa ,&nbsp;Trobjon Makhkamov ,&nbsp;Nilufar Ergasheva ,&nbsp;Abdumurod Sattarov","doi":"10.1016/j.hermed.2024.100954","DOIUrl":"10.1016/j.hermed.2024.100954","url":null,"abstract":"<div><h3>Introduction</h3><div>Scientists consider repurposing discarded waste into valuable resources for the pharmaceutical, cosmetic, and food flavoring manufacturing industries a challenge to generate new revenue streams, lower production costs, and reduce waste. Therefore, the current study aimed to identify <em>Citrus limon</em> leaf volatile oil (VO) constituents from Palestine and assess its in vitro antimicrobial, anti-inflammatory, and cytotoxic properties.</div></div><div><h3>Methods</h3><div>The components of the VO were analyzed using Gas Chromatography/Mass Spectrometry (GC/MS). The antimicrobial activity of VO was assessed using a microdilution technique. The cyclooxygenases (COX-1 and COX-2) assay was utilized to assess the anti-inflammatory effect. An aqueous one solution cell proliferation (MTS) assay was employed to determine the cytotoxic effect of the VO.</div></div><div><h3>Results</h3><div>Thirty-six molecules were identified in the oil, and geranial, neral, and limonene are the most abundant molecules, comprising 31.06%, 23.98%, and 14.32%, respectively. The antimicrobial results showed that the VO has notable inhibition against <em>Proteus vulgaris,</em> Methicillin-resistant <em>Staphylococcus aureus</em>, and <em>Candida albicans</em>. The COX IC₅₀ calculations revealed that it has high potency against COX-2 IC₅₀ <!-->=<!--> <!-->9.32<!--> <!-->±<!--> <!-->0.88<!--> <!-->µg/ml. The most potent cytotoxic effect of <em>C. limon</em> VO was noticed against MCF-7, with an IC₅₀ dose of 162.90<!--> <!-->±<!--> <!-->1.85 mg/ml.</div></div><div><h3>Conclusion</h3><div>The GC-MS analyses revealed that geranial, neral, and limonene are the predominant compounds in the VO of <em>C. limon</em> leaves from Palestine. The biological test results demonstrated that the VO has potential inhibitory actions against some cancer cells, bacterial and fungal species, and COX-2 enzyme, suggesting it may be a viable choice for treating or preventing microbial infections, cancer, and inflammatory illnesses.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100954"},"PeriodicalIF":2.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity of Lannea coromandelica on B16F10 melanoma cell line: an in vitro and molecular docking approach","authors":"Prakash I. Nargatti ,&nbsp;Kiran A. Wadkar","doi":"10.1016/j.hermed.2024.100958","DOIUrl":"10.1016/j.hermed.2024.100958","url":null,"abstract":"<div><h3>Introduction</h3><div>Phytochemical screening was conducted on various bark extracts of <em>Lannea coromandelica</em> to assess their anticancer property against the B16F10 melanoma cell line. The phytoconstituents that were previously identified were utilized in molecular docking studies against the human tyrosinase related protein 1 (TYRP1) as a target receptor in order to provide more evidence for anticancer property.</div></div><div><h3>Methods</h3><div>Bark powder was extracted by maceration method using distilled water and soxhlet extraction using ethanol. The preliminary phytochemical evaluation and determination of total phenolic and flavonoid content of both extracts were conducted using biochemical assays. The present study investigated the possible anticancer effects of ethanol and aqueous extracts on the B16F10 melanoma cell line using the 3-4,5-dimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide (MTT) assay and 4,6-diamidino-2-phenylindole (DAPI) labeling techniques. The present study employed molecular docking techniques to assess the binding interactions between phytoconstituents and the TYRP1 protein, utilizing AutoDock Vina module of PyRx 0.8 software.</div></div><div><h3>Results</h3><div>The phytochemical analysis found flavonoids, steroids, terpenoids, tannins, phenolic compounds, saponins, anthraquinones, cardiac glycosides, and proteins. Ethanolic extract shown preferential cytotoxicity to B16F0 melanoma cell line <em>in-vitro</em> (IC₅₀ <!-->=<!--> <!-->9.69<!--> <!-->±<!--> <!-->0.68<!--> <!-->μg/ml), while aqueous extract exhibited IC₅₀ <!-->=<!--> <!-->75.49<!--> <!-->±<!--> <!-->5.95<!--> <!-->μg/ml. DAPI staining showed that treated cells had altered nucleus morphology, including apoptotic bodies. According to molecular docking investigations, Quercetin has the highest binding affinity (−9.6 Kcal/mol), followed by Catechin and Myricadiol.</div></div><div><h3>Conclusion</h3><div>The current investigation has determined that <em>L. coromandelica</em> exhibits cytotoxic characteristic, as evidenced by the utilization of computer aided drug design models and <em>in-vitro</em> experimentation.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100958"},"PeriodicalIF":2.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical-Chemical Characterisation and Biological Activities of the Essential Oil of Lippia alba (Mill) NE Br Ex Britton Obtained in Ecuador","authors":"C. Tubay-Bermùdez ,&nbsp;C.A. Neves ,&nbsp;A.A. Dueñas-Rivadeneira ,&nbsp;A.M. Peña ,&nbsp;L.A.Z. Mendoza ,&nbsp;K.R. Escobar ,&nbsp;D.M. Rivas-Navia ,&nbsp;N.R. Maddela","doi":"10.1016/j.hermed.2024.100951","DOIUrl":"10.1016/j.hermed.2024.100951","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Lippia alba</em> is a wild semishrubby species that grows in countries like Ecuador, its extracts have significant bioactive compounds. However, the antioxidant and antimicrobial properties of <em>L alba</em> essential oil (<strong>EO</strong>) have not been given importance in this region. The present study aimed to evaluate the physicochemical characteristics of the extracts and biological activities of <em>L alba</em> EO.</div></div><div><h3>Methods</h3><div>A unifactorial design was used, and physicochemical variables (pH, density, and refractive index) and antioxidant and antimicrobial capacities were explored using standard methods. Fractions of <em>L alba</em> EO were analysed by gas chromatography-mass spectroscopy.</div></div><div><h3>Results</h3><div>The density, pH, refractive index, and phenolic content of <em>L alba</em> EO were found to be 0.95 g/ml, 5.5, 1.51, and 918 mg/l, respectively. An antioxidant activity of 23.08 mg/l was observed by the 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulphonic) method, while 14.81 mg/l was observed by the ferric reducing antioxidant power method. Essential oil of <em>L alba</em> has presented a greater antimicrobial activity against different Gram-negative than Gram-positive bacteria. Essential oil of <em>L alba</em> showed an inhibitory zone of 56.7 and 9.7 mm against <em>Photobacterium damselae</em> sub sp. <em>piscicida</em> DSM 22834 and <em>Bacillus subtilis</em> ATCC 6633, respectively.</div></div><div><h3>Conclusions</h3><div>The results of the present investigation clearly indicated that the EO of <em>L alba</em> has potential antioxidant and antimicrobial activities <em>in vitro</em> analysis, which are important indications that this extract can be applied in different industries, such as pharmaceutical industry, food industry, and others.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100951"},"PeriodicalIF":2.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baccharis dracunculifolia DC. A Review of Research Advances From 2004 to 2024, With New Micromorphology and Essential Oil Investigations","authors":"Lorene Armstrong ,&nbsp;Paola Aparecida Raeski ,&nbsp;Valter Paes de Almeida ,&nbsp;Manuel Minteguiaga ,&nbsp;Andressa Novatski ,&nbsp;Vijayasankar Raman ,&nbsp;Arquimedes Gasparotto Junior ,&nbsp;C. Benjamin Naman ,&nbsp;Jane Manfron","doi":"10.1016/j.hermed.2024.100952","DOIUrl":"10.1016/j.hermed.2024.100952","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Baccharis dracunculifolia</em> DC. (Asteraceae)<em>,</em> called alecrim-do-campo, vassoura, or vassourinha, is the precursor of green propolis that is used in traditional medicine for treating conditions such as dyspepsia, fatigue, inflammation, mild fever, and high blood pressure. This study aimed to summarise botanical, chemical, pharmacologic, and toxicologic reports about <em>B. dracunculifolia</em> and contribute new information on its anatomy and essential oil composition.</div></div><div><h3>Methods</h3><div>This study reviewed international databases, querying keywords related to traditional use, phytochemicals, biological activities (excluding animal studies), nanotechnology, clinical trials, and toxicity. New contributions regarding micromorphology of leaves and stems were analysed by light and scanning electron microscopy, and crystals were observed by polarised microscopy, energy dispersive X-ray, and Raman spectroscopies. Essential oils and hydrolates were generated from distinct sites and analysed using gas chromatography/mass spectrometry.</div></div><div><h3>Results</h3><div>Botanical, chemical, pharmacologic, and toxicologic studies of <em>B. dracunculifolia</em> are reviewed herein along with this plant’s use in nano- and biotechnological applications. Major compounds present in the essential oils and volatile extracts of <em>B. dracunculifolia</em> include monoterpenes and sesquiterpenes, while the organic extracts are rich in phenolics (flavonoids, caffeoylquinic, and prenylated acids) and terpenoids (diterpenoids and triterpenoids).</div></div><div><h3>Conclusions</h3><div>Previously reported chemical and pharmacologic studies of <em>B. dracunculifolia</em> provided solid information about the pharmacologic effects of this medicinal plant and the green propolis produced from it. New information reported here on the micromorphology and phytochemistry (essential oil and hydrolate composition) of <em>B</em>. <em>dracunculifolia</em> can be used to facilitate the identification of this plant in comparison to other related species and for quality control.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100952"},"PeriodicalIF":2.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Control Method (UPLC-PDA) of Ajuga parviflora Benth. and Its Antiadipogenic Effect on Differentiated Preadipocytes","authors":"Vandana Kumari ,&nbsp;Abhishek Goel ,&nbsp;Dinesh Kumar ,&nbsp;Yogendra Padwad ,&nbsp;Dinesh Kumar","doi":"10.1016/j.hermed.2024.100950","DOIUrl":"10.1016/j.hermed.2024.100950","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Ajuga parviflora</em> is traditionally used for fever, diabetes, and digestive problems. Currently, Ultraperformance liquid chromatography-Photodiode array (UPLC-PDA) method to determine ajugasterone C, cyasterone, and vanillic acid in <em>A. parviflora</em> was focused to develop and validate a method for quality control perspective. Further, the evaluation of antiadipogenic and antidiabetic potential of <em>A. parviflora</em> was also targeted.</div></div><div><h3>Methods</h3><div>UPLC-PDA method was developed and validated for targeted compounds as per International Council on Harmonisation guidelines. The validated method was used to determine marker compounds in <em>A. parviflora</em> extracts (Ethanol: EtOH, 50% EtOH, and water; leaves and roots). Further, UPLC-ELSD was used to determine free sugars in samples. Moreover, the antiadipogenic effect of <em>A. parviflora</em> extracts was examined on 3T3-L1 murine preadipocytes cell line. Cells were subjected to various dosages of leaves and root extracts, and the extent of lipid accumulation was evaluated. Furthermore, cells were treated with different extracts prior to hydrogen peroxide exposure, and then the effects of <em>A. parviflora</em> treatments on oxidative stress, cell survival, and insulin sensitisation were assessed.</div></div><div><h3>Results</h3><div>The validated UPLC-PDA method was found reproducible to determine ajugasterone C, cyasterone, and vanillic acid. These compounds were found in all the samples. Biologically, leaves and roots extract of <em>A. parviflora</em> drastically suppressed adipogenesis by lowering intracellular lipid accumulation in dose-dependent manner. They improved insulin sensitivity by promoting glucose uptake and protected cellular health from oxidative damage by reducing reactive oxygen species generation and reversing apoptosis.</div></div><div><h3>Conclusions</h3><div>Findings suggested that ethanol extract of leaves exhibited potent antiadipogenic properties and UPLC-PDA will be a reproducible method to assess quality of <em>A. parviflora</em> and its derived products.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100950"},"PeriodicalIF":2.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition and antimicrobial activity of Plinia rivularis essential oil against multidrug-resistant bacteria","authors":"Gabriela Moessa Louro ,&nbsp;Eduardo João Coutinho ,&nbsp;Maiara Viviane Oliveira dos Santos ,&nbsp;Marcia Soares Mattos Vaz ,&nbsp;Marcia Regina Pereira Cabral ,&nbsp;Michele Castro de Paula ,&nbsp;Simone Simionatto ,&nbsp;Cláudia Andrea Lima Cardoso ,&nbsp;Euclésio Simionatto","doi":"10.1016/j.hermed.2024.100949","DOIUrl":"10.1016/j.hermed.2024.100949","url":null,"abstract":"<div><h3>Introduction</h3><div>The increasingly common occurrences of multidrug-resistant bacteria represent a global health threat and the discovery of new alternative remedies is necessary. The use of essential oils (EOs) in the treatment of many pathogenic bacteria is promising and several examples have already been highlighted regarding their inhibitory action. Among the botanical families, Myrtaceae stands out for presenting important species that supply bioactive products.</div></div><div><h3>Methods</h3><div>In this work we investigate the chemical composition of <em>Plinia rivularis</em> (Myrtaceae) leaf EO and its antibacterial activity against resistant and non-resistant bacteria. The EO was obtained by two methods, hydrodistillation and steam distillation. Gas chromatography-flame ionization detector (GC-FID), gas chromatograph-mass spectrometry (GC-MS), nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FTIR) were the techniques used in the EO chemical characterization.</div></div><div><h3>Results</h3><div>The EOs were obtained with yields of 0.37 and 0.16% by hydrodistillation and steam distillation methods, respectively. The analyzes revealed the EOs chemical profile showing the compounds 2H-benzocyclohepten-2-one,3,4,4a,5,6,7,8,9-octahydro-4a-methyl (synonym: 4a-methyl-3,4,4a,5,6,7,8,9-octahydro-2H-benzo[7]annulen-2-one), rosifoliol, β-eudesmol and the diterpene kaurene as main constituents. Through preparative thin-layer chromatography (PTLC), it was possible to obtain the diterpene kaurene with a content of 91%, which was also characterized by NMR. The minimum inhibitory concentrations of EO against bacteria ranged from 0.56 to 2.25 mg.ml⁻¹ and 2.25–36 mg.ml⁻¹ for sensitive and resistant bacteria, respectively. Also, EO showed synergistic activity with amikacin and cefotaxime against carbapenem-resistant <em>Pseudomonas aeruginosa</em> (KPC).</div></div><div><h3>Conclusions</h3><div>This is the first report on the chemical composition of <em>P. rivularis</em> EO. Comparison of extraction methods showed variation in yields and small changes in component content. The EO demonstrated activity against resistant and non-resistant bacteria. In addition, the synergistic effect of EO against resistant bacteria may be explored in future studies.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100949"},"PeriodicalIF":2.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review article on the antimicrobial and antioxidant essential oils of aromatic plants in Ethiopia","authors":"Destaw Damtie","doi":"10.1016/j.hermed.2024.100948","DOIUrl":"10.1016/j.hermed.2024.100948","url":null,"abstract":"<div><h3>Introduction</h3><div>Ethiopia has eight vegetation types across altitudes (&lt; 400 - 4533 m). Consequently, it is biologically rich (&gt; 6500–7000 plant species) with 12–19% endemicity. While medicinal plant knowledge in Ethiopia is partially documented, much remains unexplored. This study reviews the essential oils (EOs) of aromatic plants in Ethiopia, known for their antimicrobial and antioxidant properties.</div></div><div><h3>Methods</h3><div>From November to December 2022, we retrieved 28 studies from PubMed/Medline, Science Direct, SciVerse, Web of Science, and Google Scholar using boolean operators and terms such as ‘essential oil,’ ‘biological activities,’ ‘bioactivy,’ ‘antioxidant activities,’ ‘antibacterial activities,’ ‘antifungal activities,’ ‘antimicrobial activities,’ and ‘Ethiopia.’</div></div><div><h3>Results</h3><div>Promising antibacterial EOs include <em>Mentha aquatica</em>, <em>Apium leptophyllum</em>, <em>Citrus reticulata</em>, <em>Mentha arvensis</em>, <em>Mentha longifolia, Mentha piperita, Mentha spicata, Olea europaea</em>, <em>Otostegia integrifolia, Phytolacca dodecandra</em>, <em>Plectranthus marrubatus</em>, <em>Salvia nilotica</em>, <em>Salvia officinalis</em>, and <em>Salvia schimperi</em> (MICs &lt; 0.005 to 0.064 mg/mL). For antifungal activity, notable EOs include <em>Acokanthera schimperi, Cinnamomum zeylanicum, C. reticulata, C. reticulata, O. europaea, O. integrifolia, P. dodecandra, P. marrubatus, Satureja paradoxa,</em> and <em>Thymus schimperi</em> (MICs &lt; 1 mg/mL). Antioxidant essential oils were those of <em>Artemisia absinthium</em> L., <em>Artemisia abyssinica</em>, <em>Artemisia afra, Coriandrum sativum, Curcuma domestica, Juniperus procera</em>, <em>Lippia adoensis</em>, <em>Ocimum basilicum</em>, <em>O. europaea</em>, <em>Rosmarinus officinalis</em>, <em>S. officinalis</em>, <em>Satureja abyssinica</em>, and <em>S. paradoxa.</em> The IC₅₀ of all these essential oils was &lt; 0.05 mg/mL.</div></div><div><h3>Conclusion</h3><div>The present review identified the EOs of many Ethiopian aromatic plants with promising antimicrobial and antioxidant activities that demand more enquiry for preclinical testing, and eventually, clinical applications.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100948"},"PeriodicalIF":2.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of Lippia multiflora in the management of stage I hypertension: outcomes of a randomised controlled trial","authors":"Ama Kyeraa Thomford ,&nbsp;Kwesi Prah Thomford ,&nbsp;Andrews Ebo Tetteh ,&nbsp;Rosemary Sorkpor ,&nbsp;Joseph Yorke","doi":"10.1016/j.hermed.2024.100947","DOIUrl":"10.1016/j.hermed.2024.100947","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertension is a growing public health problem in the developing world. The chronic nature of the disease has been a driver for the use of traditional medicines. Clinical validation of such products for their safety and efficacy is thus of public health importance. We report on the clinical safety and effectiveness of a <em>Lippia multiflora-</em>based herbal antihypertensive <em>(LMT-19)</em>.</div></div><div><h3>Methods</h3><div>A randomised controlled study was conducted among 80 volunteers clinically diagnosed, per the WHO criteria, with stage I hypertension. Participants received either an aqueous infusion of <em>LMT-19</em> plus a standard lifestyle and dietary recommendation based on a Dietary Approaches to Stop Hypertension (DASH) diet or the lifestyle and dietary recommendation alone.</div></div><div><h3>Results</h3><div>The use of <em>LMT-19</em> resulted in a significant decline of blood pressure over a 60-day period. Diastolic blood pressure in the <em>LMT-19</em> group was found to be significantly lower compared to the control (<em>mean diff</em>: 8.25 (±1.50); <em>P</em> ≤ 0.001). Systolic blood pressure was also significantly better compared to the control group (<em>mean diff:</em> 12.70 ± 2.02; <em>P</em> ≤ 0.001). The product was also well tolerated as no adverse drug reactions were also recorded during the study.</div></div><div><h3>Conclusion</h3><div>These outcomes suggest <em>LMT-19</em> as a potential alternative remedy for management of stage I hypertension.</div></div><div><h3>Clinical trial registration</h3><div>Pan-African Clinical Trial Registry, PACTR202107733803271.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100947"},"PeriodicalIF":2.2,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of compound xueshuantong capsule in reducing cardiovascular diseases and associated ophthalmic complications: a multi-centre retrospective study","authors":"Boshi Liu ,&nbsp;Min Zhu ,&nbsp;Fei Gao ,&nbsp;Shaolin Du ,&nbsp;Minyu Chen ,&nbsp;Shuo Chen ,&nbsp;Richeng Yu ,&nbsp;Long Pang ,&nbsp;Juping Liu ,&nbsp;Xiaorong Li","doi":"10.1016/j.hermed.2024.100943","DOIUrl":"10.1016/j.hermed.2024.100943","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to explore the effectiveness and value of compound xueshuantong capsule (CXC) in the treatment of diseases by evaluating its potential to reduce cardiovascular diseases (CVDs) and ophthalmic complications.</div></div><div><h3>Methods</h3><div>A total of 5<!--> <!-->104 patients with fundus vascular diseases including retinal artery occlusion (RAO), retinal vein occlusion (RVO), diabetic retinopathy (DR), hypertensive retinopathy, periphlebitis of retina, age-related macular degeneration (AMD), central serous chorioretinopathy (CSC), and anterior ischaemic optic neuropathy (AION) were enroled across seven hospitals from 2002 to 2022. All participants were randomised categorised into two groups: CXC combination group (CXC alone or combined with hypoglycemic, lipid-lowering, or anti-hypertensive drugs, and other microcirculation and fundus angiopathy medications), and non-CXC group (only taking the above-mentioned medicines).</div></div><div><h3>Results</h3><div>Kaplan-Meier curves illustrated a lower incidence of cardio-cerebrovascular events and ophthalmic complications in CXC group compared with other group at a significant difference observed. Further stratification revealed a decreased risk of ophthalmic complications in CXC group, and supported by multivariate analysis through adjusting for baseline confounding factors.</div></div><div><h3>Discussion/Conclusions</h3><div>Our findings further confirmed the potential value of CXC in treating cardio-cerebrovascular diseases and associated ophthalmic complications, and accompanying with less side effects at the same time.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100943"},"PeriodicalIF":2.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemocompatibility and hemorheological activity of aqueous extracts from Phyllanthus sellowianus: effects on in vitro glycated erythrocytes","authors":"Hermano Mascaro Grosso ,&nbsp;Patricia Buszniez ,&nbsp;Bibiana D. Riquelme","doi":"10.1016/j.hermed.2024.100945","DOIUrl":"10.1016/j.hermed.2024.100945","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Phyllanthus sellowianus</em> (Klotzsch) Müll Arg. is an Argentinian and Brazilian native plant used to treat diabetes. In vascular diseases like diabetes, erythrocytes form anomalous aggregates resistant to dissociation, associated with high glucose levels. This work aims to evaluate the hemocompatibility and hemorheological activity of aqueous extracts from <em>P. sellowianus</em> and its anti-diabetic activity using <em>in vitro</em> glycated erythrocytes as occur by hyperglycemia.</div></div><div><h3>Methods</h3><div>For this work, <em>P. sellowianus</em> specimens were collected on the Nogoyá River coast, Argentina, and morphoanatomical identified. Infusion, maceration, digestion, and cooking extracts were prepared with collected leaves and bark using saline as solvent. The osmolality and pH of the extracts were adjusted to an adequate interaction with human cells. Red blood cells (RBCs) from healthy donors (n=3) were used and incubated with glucose solution for <em>in vitro</em> simulation of the hyperglycemia effects. RBCs were incubated with the aqueous extracts to assess their hemocompatibility. Also, glycated RBCs were incubated with the extracts to analyze their anti-diabetic properties. Erythrocyte Rheometer and Optical Chip Aggregameter were used for the hemorheological evaluation.</div></div><div><h3>Results</h3><div>Assays with the different <em>P. sellowianus</em> extracts modified the viscoelasticity and aggregation of RBCs. Moreover, in some cases, <em>P. sellowianus</em> extracts reversed the <em>in vitro</em> glycation effect and hemorheological parameters got nearer control values.</div></div><div><h3>Conclusion</h3><div>These results would be helpful for the development of pharmaceutical formulations using this species or its phytocomponents. They also give relevant information to understand the action mechanisms through which these extracts or their components can be used as anti-diabetics in Phytomedicine.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"48 ","pages":"Article 100945"},"PeriodicalIF":2.2,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}