Journal of Herbal Medicine最新文献_第5页

Ganduqing Granules for Treatment of the Common Cold: A Randomised Controlled Trial 肝毒清颗粒治疗普通感冒的随机对照试验

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1016/j.hermed.2025.101051

Jing Guo , Fei Wang , Huaqin Cao , Yilan Wang , Wenfeng Hao , Wenyuan Li

Introduction

The common cold poses significant health concerns, particularly for individuals with weakened immune systems. This study evaluates the efficacy and safety of Ganduqing granules (GG), a proprietary Chinese medicine, in treating cold symptoms among susceptible population.

Methods

Participants aged 18–70, who experienced more than four colds annually, with symptom onset within 48 hours, and who had received no prior treatment were included. They were randomly assigned to GG group or placebo group and were evaluated at baseline and follow-up. The participants and investigators were double-blinded. The primary outcome was the overall symptom recovery time. Other outcomes included individual symptom recovery, clinical remission rates, immune cell percentages, cytokine levels, and oxidative stress markers.

Results

A total of 120 participants were enroled and evenly divided into two groups. The full analysis set included 118 participants, and the per protocol set included 108 participants. The mean time to overall symptom recovery in the Ganduqing group (60 cases) was 84.93 ± 25.95 hours, and that in the placebo group (58 cases) was 96.19 ± 20.50 hours; the former was significantly shorter than the latter by 11.26 hours (95% CI: −19.69 to −2.84, P = 0.009). By day three, the GG group showed markedly higher recovery rates compared to the control group, with a relative risk of 2.11 (95% CI: 1.14–3.90). Immune cells and cytokine analyses suggested immunomodulatory effects.

Conclusions

GG effectively shortens the duration of cold symptoms, possibly by modulating the immune system and reducing inflammation.

普通感冒引起严重的健康问题，特别是对免疫系统较弱的人。本研究评价中药甘毒清颗粒治疗感冒易感人群感冒症状的疗效和安全性。研究对象年龄在18-70岁之间，每年感冒4次以上，在48 小时内出现症状，且未接受过任何治疗。随机分为GG组和安慰剂组，分别在基线和随访时进行评估。参与者和调查人员是双盲的。主要观察指标为总体症状恢复时间。其他结果包括个体症状恢复、临床缓解率、免疫细胞百分比、细胞因子水平和氧化应激标志物。结果共入组120人，平均分为两组。完整的分析集包括118名参与者，每个方案集包括108名参与者。甘度清组（60例）平均症状恢复时间为84.93 ± 25.95 小时，安慰剂组（58例）平均症状恢复时间为96.19 ± 20.50 小时；前者明显短于后者11.26 小时（95% CI:−19.69 ~−2.84,P = 0.009）。到第三天，GG组的恢复率明显高于对照组，相对危险度为2.11 （95% CI: 1.14-3.90）。免疫细胞和细胞因子分析提示免疫调节作用。结论甘露可有效缩短感冒症状持续时间，可能与调节免疫系统、减轻炎症有关。

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引用次数: 0

Ethnobotanical review of antidiarrhoeal medicinal plants used in the KwaZulu-Natal Province, South Africa 南非夸祖鲁-纳塔尔省使用的抗腹泻药用植物的民族植物学综述

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1016/j.hermed.2025.101072

Siyanda Mhlongo , Annah Moteetee , Fidele Tugizimana , Saheed Sabiu

Introduction

Diarrhoea remains a major public health challenge in sub-Saharan Africa, particularly among children under five. In the KwaZulu-Natal Province, South Africa, traditional medicine is widely used to treat diarrhoeal diseases. Although several plants are used in the province to treat diarrhoea, no comprehensive review synthesising the available literature has been published to date. Therefore, this study aimed to undertake a systematic review of the ethnobotanical knowledge on medicinal plants used traditionally to manage diarrhoea in the KwaZulu-Natal Province.

Methods

The preferred reporting items for systematic reviews and meta-analyses guidelines were followed. Relevant English-language studies published up to January 2023 were retrieved from PubMed, ScienceDirect, Web of Science, Scopus, and Google Scholar. Theses and dissertations were accessed from the University of Johannesburg repository.

Results

From 65 eligible studies, 67 medicinal plants from 33 families were recorded. Asteraceae and Fabaceae were the most represented families (13.43% each). Trees dominated growth forms (42.11%), while leaves (24.78%) and bark (23.89%) were the most used plant parts. Decoctions (76.12%) and infusions (20.89%) were the primary preparation methods, with oral and enema routes as the main administration modes.

Conclusions

This review provides the first province-specific ethnobotanical synthesis of antidiarrhoeal medicinal plants in KwaZulu-Natal. The findings offer a foundation for pharmacological validation, inform conservation efforts, and support the integration of traditional knowledge into evidence-based healthcare strategies.

腹泻仍然是撒哈拉以南非洲的一项重大公共卫生挑战，特别是在五岁以下儿童中。在南非夸祖鲁-纳塔尔省，传统医学被广泛用于治疗腹泻病。虽然该省有几种植物用于治疗腹泻，但迄今为止尚未发表综合现有文献的综合评论。因此，本研究旨在对夸祖鲁-纳塔尔省传统上用于治疗腹泻的药用植物的民族植物学知识进行系统审查。方法采用系统评价和meta分析指南的首选报告项目。截至2023年1月发表的相关英文研究检索自PubMed、ScienceDirect、Web of Science、Scopus和谷歌Scholar。论文和学位论文可从约翰内斯堡大学的知识库访问。结果从符合条件的65项研究中，共记录到33科67种药用植物。以菊科和豆科最具代表性，各占13.43%。以乔木为主（42.11%），以叶（24.78%）和树皮（23.89%）为主。以煎煮（76.12%）和输液（20.89%）为主，口服和灌肠为主要给药方式。结论本综述首次在夸祖鲁-纳塔尔省提供了具有省特异性的抗腹泻药用植物的民族植物学合成。这些发现为药理学验证提供了基础，为保护工作提供了信息，并支持将传统知识整合到循证医疗保健策略中。

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引用次数: 0

Cocrystal of flavonoids as potential phyto-therapeutic agents against SARS-CoV-2: a scoping review 类黄酮共晶作为抗SARS-CoV-2的潜在植物治疗剂：范围综述

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.hermed.2025.101057

Bonta Ramesh Kumar, Kottur Mohan Kumar, Saikat Sen, Srinivas Oruganti

Background

Natural products have gained popularity over the last two decades due to their remarkable pharmacological properties, which include anti-cancer, antiviral, anti-inflammatory, and antibacterial effects. These characteristics make them naturally existing potential candidates for the creation of novel medications. Flavonoids, a well-known family of secondary metabolites, have shown antiviral efficacy against SARS-CoV-2. Since these natural bioactives have a low solubility in aqueous medium, their bioavailability studies are however severely impeded.

Objective

The study focuses on the co-crystallisation process, a cutting-edge and promising strategy for enhancing the bioavailability of weakly water-soluble pharmaceuticals, such as flavonoids. The review examines flavonoids, their function against SARS-CoV-2, and their antiviral potential, as well as cocrystals, recent cocrystal production methods, flavonoid cocrystals developed to date, and the possibilities of developing flavonoid cocrystals to combat SARS-CoV-2 infection.

Methods

PubMed, Scopus database, Web of Science, and Google Scholar were accessed for the literature search. The data was compiled based on the abstract, titles, and relevance of work.

Results

The expository review of the literature indicated that numerous cocrystals of flavonoids have been developed to address challenges related to their bioavailability. These developed cocrystals have better physicochemical features and pharmacological activity.

Conclusion

Cocrystals containing antiviral flavonoids may be a promising strategy for treating viral illnesses, with a high success rate as observed in preliminary studies. The authors believe that by producing flavonoid cocrystals utilising innovative techniques, flavonoid solubility and absorption rates can be improved.

在过去的二十年中，天然产品因其显著的药理特性而受到欢迎，包括抗癌、抗病毒、抗炎和抗菌作用。这些特征使它们自然成为创造新型药物的潜在候选者。类黄酮是一种众所周知的次生代谢物家族，已显示出对SARS-CoV-2的抗病毒作用。由于这些天然生物活性物质在水介质中的溶解度较低，因此它们的生物利用度研究受到严重阻碍。目的研究提高弱水溶性药物（如黄酮类化合物）生物利用度的一种前沿和有前途的共结晶方法。本文综述了类黄酮及其抗SARS-CoV-2的功能和抗病毒潜力，以及共晶、最近的共晶生产方法、迄今为止开发的类黄酮共晶，以及开发抗SARS-CoV-2感染的类黄酮共晶的可能性。方法使用spubmed、Scopus数据库、Web of Science和谷歌Scholar进行文献检索。数据是根据论文摘要、标题和相关性进行整理的。结果通过对相关文献的综述，发现了大量的类黄酮共晶，以解决其生物利用度方面的问题。这些发育的共晶具有较好的理化特性和药理活性。结论含有抗病毒类黄酮的共晶可能是治疗病毒性疾病的一种有前景的策略，初步研究表明其成功率较高。作者认为，利用创新技术制备类黄酮共晶可以提高类黄酮的溶解度和吸收率。

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引用次数: 0

Combination therapy of Qi Huang Tong Mi soft capsule and probiotics enhances clinical outcomes in severe acute pancreatitis 芪黄通糜软胶囊联合益生菌治疗重症急性胰腺炎疗效观察

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1016/j.hermed.2025.101044

Huicong Ma , Feng Cheng , Zhaohui Du , Zhaoyang Du , Hongchang Zhao , Zhaolei Qiu

Introduction

Severe acute pancreatitis (SAP) involves systemic inflammation and intestinal barrier dysfunction. This study aimed to assess the efficacy of Qi Huang Tong Mi soft capsules combined with gut probiotics in the treatment of SAP.

Methods

A total of 120 SAP patients were randomised into four groups: the experimental group (Qi Huang Tong Mi + probiotics + standard care), Qi Huang group, probiotics group, and control group. Treatments lasted 14 days. Inflammatory markers, intestinal barrier indicators, and clinical outcomes were evaluated on days 7 and 14.

Results

The experimental group demonstrated the highest efficacy rate (96.67%), with significant reductions in C-reactive protein (CRP), IL-6, IL-8, TNF-α, procalcitonin (PCT), alone with improved gut barrier function. Faster symptom relief, shorter hospital stays, and fewer complications were observed (P < 0.05).

Conclusions

Qi Huang Tong Mi combined with probiotics effectively and safely reduces inflammation, restores intestinal barrier function, and improves clinical outcomes in SAP patients.

重症急性胰腺炎（SAP）包括全身性炎症和肠屏障功能障碍。方法将120例SAP患者随机分为实验组（芪黄通糜+益生菌+标准治疗）、芪黄组、益生菌组和对照组。治疗持续14天。在第7天和第14天评估炎症标志物、肠道屏障指标和临床结果。结果实验组有效率最高（96.67%），c -反应蛋白（CRP）、IL-6、IL-8、TNF-α、降钙素原（PCT）均显著降低，同时肠道屏障功能改善。患者症状缓解快，住院时间短，并发症少（P < 0.05）。结论芪黄通糜联合益生菌可有效、安全地减轻SAP患者炎症反应，恢复肠道屏障功能，改善临床预后。

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引用次数: 0

Potential Protective Effects of Quercetin on Acute Kidney Injury: An Integrated Study of Network Pharmacology, GEO Database, and Experimental Validation 槲皮素对急性肾损伤的潜在保护作用：网络药理学、GEO数据库和实验验证的综合研究

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1016/j.hermed.2025.101049

Yuanyuan Jiang , Yihan Lai , Guihua Zeng , Chengsheng Liu , Jian Ruan , Guoqing Wu

Introduction

This study explored the active components and mechanisms of Cistanche deserticola Ma (CH) in treating acute kidney injury (AKI) using network pharmacology, GEO data, and experimental validation.

Methods

Active compounds and targets of CH were identified from TCMSP, SwissTargetPrediction, and Herb databases. AKI-related genes were sourced from GeneCards, OMIM, and GEO. A protein-protein interaction network of overlapping targets was constructed via STRING, with key nodes ranked using CytoNCA. Gene ontology/Kyoto Encyclopaedia of Genes and Genomes enrichment was performed in R, and a target-pathway network was built in Cytoscape. Molecular docking was conducted with Discovery Studio and visualised in Pymol. In vitro assays, including MTT, flow cytometry, and Western blotting, validated quercetin’s effects on lipopolysaccharides-induced human renal tubular epithelial cell injury.

Results

Five active CH compounds and 397 potential targets were identified, with 221 overlapping AKI targets. Core targets included TP53, IL-6, AKT1, EGFR, TNF, and SRC. Enrichment analysis highlighted the PI3K/AKT pathway, apoptotic regulation, and xenobiotic response. Quercetin showed strong binding to core targets and reduced apoptosis via PI3K/AKT inhibition in vitro.

Conclusions

CH may protect against AKI through PI3K/AKT pathway modulation, supporting its therapeutic potential.

本研究通过网络药理学、GEO数据和实验验证，探讨肉苁蓉（chstanche deserticola Ma， CH）治疗急性肾损伤（acute kidney injury， AKI）的有效成分及其作用机制。方法从TCMSP数据库、SwissTargetPrediction数据库和Herb数据库中鉴定其活性成分和靶点。aki相关基因来源于GeneCards、OMIM和GEO。通过STRING构建重叠靶点的蛋白-蛋白相互作用网络，使用CytoNCA对关键节点进行排序。基因本体/京都基因和基因组百科全书富集在R中进行，目标通路网络在Cytoscape中构建。通过Discovery Studio进行分子对接，并在Pymol中进行可视化。体外实验，包括MTT、流式细胞术和Western blotting，验证了槲皮素对脂多糖诱导的人肾小管上皮细胞损伤的作用。结果共鉴定出5个活性CH化合物和397个潜在靶点，其中221个与AKI靶点重叠。核心靶点包括TP53、IL-6、AKT1、EGFR、TNF和SRC。富集分析强调了PI3K/AKT通路、凋亡调控和异种生物反应。槲皮素显示出与核心靶点的强结合，并通过体外抑制PI3K/AKT减少细胞凋亡。结论sch可能通过调节PI3K/AKT通路对AKI有保护作用，支持其治疗潜力。

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引用次数: 0

Chinese herbal medicine for urticaria: a systematic review and meta-analysis of 26 randomised controlled trials 中药治疗荨麻疹：26项随机对照试验的系统回顾和荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1016/j.hermed.2025.101046

Shasha Jiang , Xiaojie Ding , Mi Zhou , Ruiping Wang , Yi Yan , Bin Li , Le Kuai , Yong Xiang

Objective

To assess the clinical efficacy and safety of Chinese herbal medicine (CHM) in the treatment of urticaria.

Methods

A search was conducted in the databases of Wanfang, China National Knowledge Infrastructure, VIP, Embase, China Biomedical Literature Database, Cochrane Library, PubMed, and Web of Science until February 2024 for randomised controlled trials (RCTs) involving the use of CHM for the treatment of urticaria. Two researchers independently conducted a literature search and data extraction, and conducted a methodological quality assessment of the included studies using the Cochrane Bias Assessment Tool. They also conducted a meta-analysis using the RevMan5.3 software.

Results

A total of 26 literatures were included (19 of which were related to chronic urticaria), involving 2 608 patients (patients with chronic urticaria accounted for approximately 78.0%). The meta-analysis results showed that in the treatment of urticaria, CHM was more effective than Western medicine (P < 0.00001), had a lower recurrence rate (P < 0.00001), and had a lower incidence of adverse reactions (P < 0.00001). Subgroup analysis showed that the therapeutic effect of traditional Chinese medicine was significantly advantageous in patients with chronic urticaria (RR = 1.23, 95% CI, 1.11–1.37).

Conclusion

In this study, the treatment of urticaria with CHM proves superior to that with Western medicine and is of greater safety.

目的评价中药治疗荨麻疹的临床疗效和安全性。方法检索万方、中国国家知识基础设施、VIP、Embase、中国生物医学文献数据库、Cochrane图书馆、PubMed和Web of Science数据库，检索截至2024年2月涉及中草药治疗荨麻疹的随机对照试验（RCTs）。两位研究人员独立进行了文献检索和数据提取，并使用Cochrane偏倚评估工具对纳入的研究进行了方法学质量评估。他们还使用RevMan5.3软件进行了荟萃分析。结果共纳入26篇文献（其中与慢性荨麻疹相关的文献19篇），涉及2 608例患者（慢性荨麻疹患者约占78.0%）。荟萃分析结果显示，中药治疗荨麻疹的疗效优于西药（P < 0.00001），复发率更低（P < 0.00001），不良反应发生率更低（P < 0.00001）。亚组分析显示，中药治疗慢性荨麻疹疗效显著优势（RR = 1.23, 95% CI, 1.11-1.37）。结论中药治疗荨麻疹优于西药治疗，安全性更高。

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引用次数: 0

Cross-cultural comparison of antidiabetic medicinal plants used in Algeria and Morocco 阿尔及利亚和摩洛哥抗糖尿病药用植物的跨文化比较

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-01 Epub Date: 2025-07-16 DOI: 10.1016/j.hermed.2025.101043

Sarra Maamri , Mourad Djeziri , Souhila Mendil , Lydia Terfi

Introduction

Diabetes is a chronic endocrine disease of global concern. The aim of this study is to provide a comparative analysis of ethnomedical practice used for diabetes management in Algeria and Morocco, offering a scientific basis for the development of alternative therapies and innovative drug discovery.

Methods

Ethnomedical information was normalised from quantitative ethnobotanical studies. Principal component analysis (PCA) was used to compare regional data, complemented by hierarchical ascending classification (HAC) to identify similarity in plant use, plant parts, and preparation methods.

Results

A total of 225 species (68 families) in Algeria and 222 species (64 families) in Morocco were identified, with 95 species common to both countries (around 30%). PCA revealed interregional variabilities of 42.60% (Algeria) and 43.43% (Morocco). HAC subdivided the heterogeneous dataset into homogeneous groups based on plant usage, plant parts, and preparation modes. These groupings reflect both a shared ethnomedicinal heritage and region-specific adaptations, highlighting the balance between redundancy and divergence within the phytotherapeutic practice, which underpins its stability and therapeutic diversity.

Conclusion

This study demonstrates that ethnobotanical knowledge is a dynamic and valuable resource, transcending cultural boundaries and providing a robust foundation for the discovery of novel antidiabetic formulations. The nuanced balance between common frameworks and unique phytotherapeutic specificities supports the development of complementary or synergistic therapies.

糖尿病是一种全球关注的慢性内分泌疾病。本研究的目的是对阿尔及利亚和摩洛哥用于糖尿病管理的民族医学实践进行比较分析，为开发替代疗法和创新药物提供科学依据。方法将定量民族植物学研究的民族医学信息归一化。采用主成分分析（PCA）对区域数据进行比较，并辅以层次上升分类（HAC）来确定植物用途、植物部位和制备方法的相似性。结果阿尔及利亚共鉴定出68科225种，摩洛哥共鉴定出64科222种，其中两国共有95种（约占30%）。主成分分析显示阿尔及利亚和摩洛哥的区域间变异率分别为42.60%和43.43%。HAC根据植物用途、植物部位和制备方式将异构数据集细分为同质组。这些分组既反映了共同的民族医学遗产，也反映了特定区域的适应性，突出了植物治疗实践中冗余和差异之间的平衡，从而巩固了其稳定性和治疗多样性。结论民族植物学知识是一种动态的、有价值的资源，它超越了文化界限，为发现新的抗糖尿病配方提供了坚实的基础。共同框架和独特植物治疗特异性之间的微妙平衡支持了互补或协同疗法的发展。

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引用次数: 0

Efficacy and safety of Chinese herbal medicines in reducing serum uric acid levels: a systematic review and meta-analysis 中药降低血清尿酸水平的有效性和安全性：一项系统评价和荟萃分析

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1016/j.hermed.2025.101041

Zhuanzhuan Li , Yingmei Fu , Caiyun Zhou , Xin Wang , Weihong Cong , Shanqiong Xu , Yuqing Ye , Bingbing Fan , Fang Ma

Background

Hyperuricemia (HUA), a metabolic disorder resulting from abnormalities in purine metabolism or impaired renal uric acid excretion, has shown a rising global prevalence. Although Chinese herbal medicine (CHM) exhibits therapeutic potential for HUA, strong evidence supporting its efficacy and safety remains limited.

Objective

This study aimed to systematically evaluate the efficacy and safety of oral CHM in lowering serum uric acid (SUA) levels.

Methods

Randomised controlled trials (RCTs) published between January 2013 and February 2024 were retrieved from PubMed, Embase, Cochrane Library, Web of Science, CNKI, CBM, and Wanfang databases. Meta-analyses were performed using Review Manager 5.4, along with sensitivity analyses, meta-regression, and subgroup analyses to explore heterogeneity. Study quality was assessed using the Cochrane Risk of Bias tool.

Results

A total of 53 RCTs involving 5 176 patients were included. CHM monotherapy or CHM combined with Western medicine (WM) significantly reduced SUA levels compared to WM alone (MD = −45.28, 95% CI: −55.06 to −35.50, P < 0.0001). Adverse events occurred in 8.79% of patients receiving CHM or CHM + WM, significantly lower than in the WM control group (RR = 0.63, 95% CI: 0.48–0.83, P = 0.0009).

Conclusion

Oral CHM shows significant efficacy and a favourable safety profile in reducing SUA levels, representing a promising alternative for HUA management. However, these findings require confirmation through large-scale, high-quality RCTs due to heterogeneity and methodological limitations in existing studies.

高尿酸血症（HUA）是一种由嘌呤代谢异常或肾脏尿酸排泄受损引起的代谢性疾病，在全球范围内的患病率正在上升。尽管中草药（CHM）显示出治疗HUA的潜力，但支持其有效性和安全性的有力证据仍然有限。目的系统评价口服中药降低血清尿酸（SUA）水平的疗效和安全性。方法从PubMed、Embase、Cochrane Library、Web of Science、CNKI、CBM和万方数据库中检索2013年1月至2024年2月发表的随机对照试验（RCTs）。使用Review Manager 5.4进行meta分析，同时进行敏感性分析、meta回归和亚组分析，以探索异质性。使用Cochrane偏倚风险工具评估研究质量。结果共纳入53项rct， 5 176例患者。与单用中西医结合（WM）相比，中西医单药治疗或中西医结合（WM）显著降低SUA水平（MD = - 45.28, 95% CI: - 55.06 ~ - 35.50, P < 0.0001）。CHM组或CHM + WM组不良事件发生率为8.79%，显著低于WM对照组（RR = 0.63, 95% CI: 0.48 ~ 0.83, P = 0.0009）。结论口服中草药在降低SUA水平方面具有显著的疗效和良好的安全性，是治疗HUA的一种有希望的替代方法。然而，由于现有研究的异质性和方法学局限性，这些发现需要通过大规模、高质量的随机对照试验来证实。

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引用次数: 0

Ethnopharmacological survey of medicinal plants used in the treatment of female infertility in two localities of Melong subdivision-Cameroon 喀麦隆梅龙分区两个地区治疗女性不育症药用植物的民族药理学调查

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-01 Epub Date: 2025-07-11 DOI: 10.1016/j.hermed.2025.101042

Rose Winny Ebong Eyango , Landry Lienou Lienou , Marie Stephanie Chekem Goka , Richard Tagne Simo , Fabrice Fabien Dongmo Dongho , Leonce Martin Tchiffo Noubosse , Rosalie Anne Ngono Ngane , Bruno Phélix Telefo

Introduction

The scarcity of conventional infertility treatments and the erosion of traditional medicinal knowledge pose significant challenges. This study aims to document and preserve herbal remedies of Moungo’s division against female infertility, leveraging the rich heritage of ancestral healing practices.

Methods

An ethnopharmacological survey was conducted on twenty traditional healers in Mbouroukou and Mouanguel, localities of the Melong sub-division (Littoral-Cameroon). A structured questionnaire collected data on plant-based treatments, supplemented by a comprehensive literature review on the botanical and therapeutic properties of these plants.

Results

The survey identified 50 plant species belonging to 35 families, utilised in 31 recipes. The majority of these recipes (19) combined multiple plants, while 12 were single-plant preparations. The Leaf was the most commonly used plant part (37.15%), with decoction being the primary preparation method (55.20%). Water was the mostly used solvent (75.85%) and treatments were predominantly administered via the anal route (54.84%), with dosages ranging from one to twelve purge bulbs per day over various treatment durations. Notably, Solanum aculeastrum, Musa parasidiaca, Ageratum conyzoides, and Commelina benghalensis were the plants most frequently mentioned by the interviewees.

Conclusion

The study reveals a rich diversity of therapeutic knowledge among traditional healers in Melong subdivision for treating female infertility. Acknowledging and integrating this ethnobotanical knowledge is essential for the conservation of medicinal plant species and the optimisation of therapeutic interventions aimed at improving women's reproductive health outcomes.

传统不孕症治疗的稀缺和传统医学知识的侵蚀构成了重大挑战。本研究旨在记录和保存蒙戈师治疗女性不孕症的草药，利用丰富的祖先治疗实践遗产。方法对喀麦隆沿海梅龙分区Mbouroukou和Mouanguel地区20名传统医师进行民族药理学调查。一份结构化的调查问卷收集了基于植物的治疗数据，并辅以对这些植物的植物学和治疗特性的全面文献综述。结果共鉴定出35科50种植物，应用于31种配方中。这些配方中大多数（19个）组合了多株植物，而12个是单株植物制剂。叶是最常用的植物部位（37.15%），汤剂是主要的制备方法（55.20%）。水是最常用的溶剂（75.85%），治疗主要通过肛门途径进行（54.84%），在不同的治疗持续时间内，每天的剂量从1到12个清洗球不等。值得注意的是，被采访者提到最多的植物是龙葵（Solanum acleastrum）、寄生木（Musa parasidiaca）、鹰嘴藤（Ageratum conyzoides）和板栗（Commelina benghalensis）。结论梅龙分区传统医师对女性不孕症的治疗知识具有丰富的多样性。承认和整合这种民族植物学知识对于保护药用植物物种和优化旨在改善妇女生殖健康结果的治疗干预措施至关重要。

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引用次数: 0

Ethnobotanical study of plants used in treating skin ailments and dermato-cosmetics among population of Sidi Kacem, Northeast of Morocco 摩洛哥东北部Sidi Kacem人群中用于治疗皮肤病和皮肤化妆品的植物的民族植物学研究

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine

Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1016/j.hermed.2025.101045

Mostafa El Khomsi , Anouar Hmamou , Nor El houda Tahiri , Najoua Soulo , Meryem Doubi , Driss Hmouni

Introduction

To address the threat of the disappearance of oral knowledge of traditional medicinal and cosmetic plants, an ethnobotanical study of plants used in treating skin diseases and dermato-cosmetics was carried out in the Sidi Kacem region.

Methods

A total of 530 local residents took part in the study. The method adopted was based on semi-structured interviews with open-ended questions. The data collected were analysed using basic statistical tools and quantitative indices such as use value of botanical family (FUV), species use value (SUV), Fidelity level (FL), informant agreement ratio (IAR) and part of the plant value (PPV).

Results

A total of 84 plant species in 41 botanical families were recorded, with a marked predominance of the Lamiaceae family, represented by 11 species (FUV = 0,18). Among these plants, Rosmarinus officinalis L. has the highest use value (SUV = 0,63). In terms of conditions treated, cosmetic uses and viral infections have the highest index of informant agreement ratio (IAR = 0,97). The maximum fidelity level reached 100, indicating a high degree of consistency in plant use. Leaves are the most frequently used part (PPV = 0,478), while powder form is the most common method of preparing remedies.

Discussion/Conclusion

The survey highlighted the diversity of plant species and the strength of traditional knowledge associated with medicinal and cosmetic plants. Based on these results, the researchers encourage the scientific community to further investigate the phytochemical and pharmacological properties of local medicinal plants.

Data and model availability statement

The datasets used and/or analyzed during the current study are available in the manuscript.

为了解决传统药用和化妆品植物口头知识消失的威胁，在Sidi Kacem地区对用于治疗皮肤病和皮肤化妆品的植物进行了民族植物学研究。方法共有530名当地居民参与了研究。所采用的方法是基于带有开放式问题的半结构化访谈。采用植物科利用价值（FUV）、物种利用价值（SUV）、保真度水平（FL）、知情同意率（IAR）和部分植物价值（PPV）等基本统计工具和定量指标对收集到的数据进行分析。结果共记录到41科84种植物，其中Lamiaceae占优势，有11种（FUV = 0,18）。其中，利用价值最高的是迷迭香（Rosmarinus officinalis L.）（SUV = 0,63）。在治疗条件方面，化妆品使用和病毒感染具有最高的知情同意比指数（IAR = 0.97）。最高保真度达到100，表明植物使用的一致性很高。叶子是最常用的部分（PPV = 0,478），而粉末形式是制备补救措施的最常用方法。讨论/结论该调查突出了植物物种的多样性和药用和化妆品植物相关的传统知识的力量。基于这些结果，研究人员鼓励科学界进一步研究当地药用植物的植物化学和药理特性。数据和模型可用性声明当前研究中使用和/或分析的数据集可在手稿中获得。

{"title":"Ethnobotanical study of plants used in treating skin ailments and dermato-cosmetics among population of Sidi Kacem, Northeast of Morocco","authors":"Mostafa El Khomsi , Anouar Hmamou , Nor El houda Tahiri , Najoua Soulo , Meryem Doubi , Driss Hmouni","doi":"10.1016/j.hermed.2025.101045","DOIUrl":"10.1016/j.hermed.2025.101045","url":null,"abstract":"<div><h3>Introduction</h3><div>To address the threat of the disappearance of oral knowledge of traditional medicinal and cosmetic plants, an ethnobotanical study of plants used in treating skin diseases and dermato-cosmetics was carried out in the Sidi Kacem region.</div></div><div><h3>Methods</h3><div>A total of 530 local residents took part in the study. The method adopted was based on semi-structured interviews with open-ended questions. The data collected were analysed using basic statistical tools and quantitative indices such as use value of botanical family (FUV), species use value (SUV), Fidelity level (FL), informant agreement ratio (IAR) and part of the plant value (PPV).</div></div><div><h3>Results</h3><div>A total of 84 plant species in 41 botanical families were recorded, with a marked predominance of the Lamiaceae family, represented by 11 species (FUV = 0,18). Among these plants, <em>Rosmarinus officinalis</em> L. has the highest use value (SUV = 0,63). In terms of conditions treated, cosmetic uses and viral infections have the highest index of informant agreement ratio (IAR = 0,97). The maximum fidelity level reached 100, indicating a high degree of consistency in plant use. Leaves are the most frequently used part (PPV = 0,478), while powder form is the most common method of preparing remedies.</div></div><div><h3>Discussion/Conclusion</h3><div>The survey highlighted the diversity of plant species and the strength of traditional knowledge associated with medicinal and cosmetic plants. Based on these results, the researchers encourage the scientific community to further investigate the phytochemical and pharmacological properties of local medicinal plants.</div></div><div><h3>Data and model availability statement</h3><div>The datasets used and/or analyzed during the current study are available in the manuscript.</div></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"53 ","pages":"Article 101045"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0