Journal of Herbal Medicine最新文献

Introduction

Lung cancer has one of the highest death rates in the world. modern medicine is the main treatment, but it has many side effects. Scholars have turned their attention to botanical drugs. It is found that in addition to treating lung cancer, it can also reduce side effects, improve the immunity of patients and the quality of lives of patients.

Methods

We searched journal papers from the Web of Science database dated from January 2002 to March 2023 in the field of botanical drugs treating lung cancer, we used Cite Space, VOS viewer, Pajet analysis software to analyze publication, author, institution, country, keyword, keyword cluster, journals of co-citation analysis, burst keyword, and drew visual maps.

Results

814 articles were obtained,Liu Liang published the most papers in the field, Shanghai University of Traditional Chinese Medicine was an important scientific research institution, and it had more cooperation with other institutions. China had the largest number of publications. The research content mainly focused on lung cancer, apoptosis, traditional Chinese medicine, Chinese herb medicine, efficacy, chemotherapy, signalling pathways, mechanisms, and in vitro. Ten significant clusters were generated by keyword cluster analysis. The Journal Of Ethnopharmacology (929 citations) and Cancer Research (683 citations) were excellent journals in the JCR1 region. The top 18 burst keywords showed the hot research issues in the past more than 20 years.

Conclusion

The research is still in initial stage. This paper shows the current situation, research progress, and hotspots of the field with the help of visual maps.

Introduction

Spices, derived from plant products, contain distinct aromatic substances that enhance the ,flavour, taste, and overall quality of food. The rich diversity in flora, fauna, and culture in the Northeastern states of India is reflective of unique food habits. In addition to utilising wild edible plants in their cuisine, these communities incorporate certain plant species for food preservation and flavour enhancement in traditional food preparation.

Methods

This review aims to shed light on the often-overlooked anticancer properties of locally available spice plants. The focus is on identifying bioactive compounds within these plants that contribute to their potential health benefits. The study assesses the anticancer activities of crude extracts and bio-active compounds obtained from 17 spices against various types of cancer.

Results

Among 34 bioactive compounds from spices, 2-methoxycinnamaldehyde, thymoquinone, piperine and Isoegomaketone exhibit the highest anticancer activity. The primary mechanisms underlying the anticancer activities of these spices involve inducing apoptosis, inhibiting proliferation and metastasis, and modulating the expression of apoptotic genes, proteins, and associated pathways. Notably, specific bioactive compounds have yet to be reported for Pimpinella anisum L, Persicaria odorata (Lour) Sojak, Zanthoxylum acanthopodium DC, and Zanthoxylum armatum DC.

Conclusions

This comprehensive review contributes valuable insights for the identification and standardisation of active plant-based pharmaceutical ingredients with promising anticancer potentials.

Introduction

Traditionally, gastrodin extracted from Rhizoma Gastrodiae has been used to treat various neurological diseases. The objective of this systematic review with meta-analysis is to evaluate the potential benefits of gastrodin as an adjuvant therapy for the treatment of acute stroke.

Methods

Relevant literature from multiple medical databases was searched until October 12, 2023, to identify randomised controlled trials investigating the use of gastrodin as an adjuvant therapy for acute stroke treatment. The total response rate and marked improvement rate were defined as >18% and >45% improvement in National Institutes of Health Stroke Scale score, respectively.

Results

A total of 12 randomised controlled trials, including 1 174 stroke patients, were identified. Compared to conventional treatment alone, the combination of gastrodin and conventional treatment significantly improved the total response rate (risk ratio 1.24; 95% CI 1.15–1.34) and marked improvement rate (risk ratio 1.37; 95% CI 1.18–1.59). Adjuvant treatment with gastrodin also resulted in a reduction in the National Institutes of Health Stroke Scale score (weighted mean difference [WMD] −3.08 points; 95% CI −3.75 to −2.41), haematoma volume (WMD −3.57 cm³; 95% CI −4.26 to −2.87), and blood neuron-specific enolase level (WMD −3.81 μg/l; 95% CI −6.21 to −1.41), as well as an increase in blood brain-derived neurotrophic factor level (WMD 0.81 ng/ml; 95% CI 0.50–1.12).

Conclusions

Gastrodin, when used as an adjuvant therapy, may yield additional beneficial effects in patients with acute stroke. However, future high-quality trials are necessary to further support this evidence.

Introduction

This single-arm pilot study aimed to investigate the effects of a 1-month Xiao-Yao-San (XYS) treatment with on objective and subjective sleep parameters among insomnia patients with and without moderate-to-severe obstructive sleep apnea (OSA)

Methods

This single-arm pre-post study included fourteen participants (average age, 48.2±15.5 years). All participants received XYS (3 g × 3 times/day, after meals) for 28 days. Among them, 7 participants had an apnea-hypopnea index (AHI) ≥15 events/hour and were classified as having moderate-to-severe OSA, while 7 patients had an AHI <15 events/hour Polysomnography was performed to evaluate the AHI, sleep stage, sleep efficiency, and sleep latency at the beginning and after 28 days of usage. Subjective questionnaires were also administered, including the Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS-A and HADS-D), and Epworth Sleepiness Scale (ESS). The Wilcoxon test was used to compare the pre-treatment and post-treatment differences

Results

Our 14 insomnia participants, with an average AHI of 21.2 events/hour at baseline who were taking XYS, exhibited a statistically significant reduction in PSQI scores (reduction of −3.0; P = 0.002) compared with the corresponding baseline values. The objective sleep evaluations did not show differences between participants with or without moderate-to-severe OSA after receiving XYS treatment. For subjective sleep parameters, only participants without moderate-to-severe OSA exhibited statistically significant improvements in sleep quality (PSQI score pretest/posttest: 10.0±3.5/7.0±3.5; P = 0.012).

Conclusions

XYS treatment may significantly improve sleep quality in participants without moderate-to-severe OSA. Further studies with larger sample sizes and longer durations are needed.

Introduction

Urinary tract infections (UTIs) are one of the most common bacterial infections accompanied by inflammation in any part of the urinary system. Antibiotics are the gold standard for UTI treatment; however, herbal products are also administered. The study aimed to assess patients' attitudes and opinions regarding the use and effectiveness of antibiotics and herbal products for the treatment of UTIs.

Methods

A quantitative, non-experimental study was conducted using an online survey in the Republic of Serbia in 2021 and 2022.

Results

The study comprised 393 respondents, with average age of 34.66 years and most respondents being women (91.9%). According to the personal assessment, slightly less than half of the respondents (46.1%) classified UTI symptoms as severe. Respondents predominantly treated UTI symptoms with herbal products combined with antibiotics (52.2%) or herbal products alone (26.6%). The most frequently used antibiotics were ciprofloxacin (20.9%), cephalexin (16.9%), and sulfamethoxazole/trimethoprim (15.4%). As many as 74.3% of respondents used herbal teas. The most used herbal products contained bearberry leaf (Uvae ursi folium) (52.1%), parsley leaf/root (Petroselini foium/radix) (15.1%), and cranberry fruit (Vaccinii macrocarpi fructus) (12.6%). Self-assessment of the effectiveness of UTI treatment with antibiotics and herbal products was high.

Conclusion

The antibiotics used to treat UTIs did not align with the guidelines of the European Association of Urologists. Further, the use of herbal products was frequently observed. Therefore, community pharmacists, who serve as the most accessible healthcare professionals with competent knowledge about herbal products, should adequately inform patients about potential therapeutic options for UTI.

Introduction

The use of herbal medicine during pregnancy is common in developing countries. Studies evaluating such use are sparse in southern Nigeria. This study sought to assess the attributes and determinants of herbal medicine use among pregnant women attending antenatal clinics at three hospitals in Uyo, Nigeria.

Methods

This was a cross-sectional survey of 650 eligible pregnant women between December 2022 and February 2023. At their antenatal appointments, participants were given a 14-item questionnaire to complete while they waited to see a doctor. Data were analyzed with SPSS version 25.0, with P < 0.05 indicating statistical significance.

Results

The prevalence of herbal medicine use in the current and previous pregnancies was 19.4% and 35.3%, respectively. The most commonly used herbal medicines were fluted pumpkin leaves (21.8%), ginger (20.5%), and mixture herbal product (16.7%). The use of such medicines was highest in the first trimester (59.4%), mostly to relieve nausea and vomiting (58.0%) and to reduce swelling of the legs (53.3%). Herbal medicine use was significantly (P < 0.05) associated with age, education, employment, number of children, whether the current pregnancy was the first, and having used herbal medicine during a previous pregnancy. Most users (63.7%) never disclosed such use to their doctor.

Conclusions

The pregnant women surveyed frequently used herbal remedies during their pregnancies; such use was associated with most of the participants’ characteristics. Healthcare professionals should routinely inquire about herbal medicines pregnant patients may be taking in addition to conventional medications and pay closer attention to conditions that cause inconvenience to them.

Introduction

Primary dysmenorrhoea (PD) is a common problem among women in their reproductive years that can negatively impact their quality of life. The present systematic review aimed to summarise the reported experimental and semi-experimental studies on the effects of different methods of oral and topical ginger to treat PD.

Methods

A literature search was performed using various databases with no language restrictions; and without any time limitation, until May 2023. The inclusion criteria of the articles included all clinical trials and semi-experimental studies conducted on humans in which ginger was used alone or in combination with other methods for pain relief of dysmenorrhoea.

Results

The review of 60 eligible articles showed that ginger is more effective than placebo in relieving pain, and there was no significant difference between ginger and nonsteroidal anti-inflammatory drugs. Most studies showed that the effects of oral ginger in the treatment of PD are greater than other herbal medicines. Most of the studies that compared oral ginger with exercise and micronutrients (including vitamin E, vitamin D, and zinc sulphate) showed a similar or superior effect of ginger. All studies conducted on topical ginger demonstrated the greater effect of its use compared to other methods.

Conclusion

There is a promising paradigm of the effect of oral and topical ginger as a potentially effective treatment for pain relief in PD. However, due to the many shortcomings in the existing studies, the findings should be interpreted with caution and more high-quality studies seem to be necessary.

Introduction

Natural products have been indispensable since immemorial and still act as a supportive healer. Parasitic diseases are a significant hurdle for humans and are responsible for global morbidity and mass mortality. Due to the building up of resistance in parasites over existing drugs and the severe side effects of the drugs, there is an urgent need to explore various plant extracts to discover novel antiparasitic agents. This article deals with the pharmacological aspects of soybeans against Plasmodium falciparum, which causes many of the deadliest and most popular diseases, such as malaria.

Methods

The molecular basis for selective inhibition of soy phytoconstituents like beta-sitosterol, soya-saponin I, soya-saponin II, soya-saponin II methyl ester, dehydrosoyasaponin I, phytic acid, and tryptophyl leucine were evaluated using in silico molecular docking approaches and molecular dynamic simulations against the falcipain-2 (FP2) and phosphoethanolamine methyltransferase (PMT) of P. falciparum.

Results

The results indicated that tryptophyl leucine exhibited potential inhibitory action against both enzymes based on pharmacophore, molecular docking, simulations, root mean square deviation, root mean square fluctuations, absorption, distribution, metabolism, excretion, and toxicity analyses.

Conclusion

Medicinal plants represent a treasure for bioactive lead compounds and eventually provide scope for further identification and investigation of novel drug candidates which may be important in the design of selective PfPMT/PfFP-2 inhibitors as potential antimalarials.

The standardisation of herbal medicine dosages presents a formidable challenge, given the vast diversity of plant species and the inherent variability in their bioactive compounds. This paper explores the historical development of standardised dosages in Western herbal medicine, highlighting the contributions of Eclectic physicians, the role of the British Herbal Pharmacopoeia of 1983, and the influence of prominent figures such as Scudder and Lloyd. The paper also highlights the progress made by China and India to establish universal dosage guidelines. However, for African Traditional Medicine, determining herbal medicine dosages remains a challenge primarily due to the extensive array of indigenous healing practices, limited resources for clinical research, and the absence of well-documented traditional medical knowledge. To address this challenge, a comprehensive strategy is proposed that encourages collaboration between traditional healers and scientists, ethnopharmacological and ethnobotanical research, and supports culturally sensitive clinical trials. This holistic approach emphasises the fusion of age-old wisdom with cutting-edge science to ensure the safety and efficacy of herbal medicine, as well as bridge the global gap in herbal medicine dosages while respecting diverse indigenous healing traditions.