Neuroscience and Biobehavioral Reviews最新文献_第3页

Looking out for danger: Theoretical and empirical issues in translating human attention bias tasks to assess animal affective states 警惕危险：将人类注意力偏差任务转化为评估动物情感状态的理论和实证问题。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105980

Sarah Kappel , Sarah Collins , Michael Mendl , Carole Fureix

Understanding animal emotional (affective) state is highly relevant to various disciplines (e.g., animal welfare, neuroscience, comparative psychology), and has been significantly advanced by translating affect-induced cognitive bias paradigms rooted in human psychology to non-human animal studies. Attention bias (i.e., preferential attention allocation, AB) tests are increasingly used as more practical substitutes to commonly used judgement bias tests. Yet, evidence that AB reflects affective valence in animals is still limited. We review in-depth the concept of attention and AB described in humans and discuss utilising human-derived AB paradigms for measuring animal affective states. We describe key concepts and functions of attention in humans, before concentrating on the relationship between AB to threat detection and human anxiety. We critically review animal AB studies, discuss methodological discrepancies in such studies, and highlight the need for further experimental refinements. This includes identifying appropriate species-specific test designs and stimuli, modes of presentation (e.g., real-life vs. artificial stimuli), and consideration of subject-related factors (e.g., personality, age). We conclude that experimental limitations currently hamper the validity of AB as a proxy of animal affect and hope that the knowledge gaps highlighted in our review will encourage further research.

了解动物的情绪（情感）状态与各学科（如动物福利、神经科学、比较心理学）密切相关，通过将植根于人类心理学的情感诱导认知偏差范式转化为非人类动物研究，动物的情绪（情感）状态得到了极大的改善。注意力偏差（即优先注意力分配，AB）测试越来越多地被用来替代常用的判断偏差测试。然而，AB 反映动物情感价位的证据仍然有限。我们深入回顾了人类的注意和AB概念，并讨论了如何利用源自人类的AB范式来测量动物的情感状态。在集中讨论 AB 与威胁检测和人类焦虑之间的关系之前，我们描述了人类注意力的关键概念和功能。我们认真回顾了动物 AB 研究，讨论了此类研究在方法上的差异，并强调了进一步完善实验的必要性。这包括确定适当的特定物种测试设计和刺激物、呈现模式（如真实生活与人工刺激物），以及考虑受试者相关因素（如性格、年龄）。我们的结论是，实验的局限性目前阻碍了 AB 作为动物情感替代物的有效性，希望我们在综述中强调的知识差距能鼓励进一步的研究。

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引用次数: 0

Prolactin in sleep and EEG regulation: New mechanisms and sleep-related brain targets complement classical data 催乳素在睡眠和脑电图调节中的作用：新机制和与睡眠相关的大脑靶点对经典数据的补充。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.106000

Attila Tóth , Árpád Dobolyi

The role of prolactin in sleep regulation has been the subject of extensive research over the past 50 years, resulting in the identification of multiple, disparate functions for the hormone. Prolactin demonstrated a characteristic circadian release pattern with elevation during dark and diminution during light. High prolactin levels were linked to non-rapid eye movement sleep and electroencephalogram delta activity in humans. Conversely, hyperprolactinemia showed strong correlation with REM sleep in rodent studies. Prolactin may be implicated in the alterations in female sleep patterns observed during the reproductive cycle, it may play a role in the REM sleep enhancement following stress and in sleep-related immunological processes. In conclusion, prolactin appears to have a sleep-promoting role, particularly during the dark phase. However, it does not appear to play a central and coherent role in sleep regulation, as observed in some neuropeptides such as orexin. Conversely, its principal function may be to facilitate situational, yet adaptive, changes in sleep patterns in response to challenging physiological phases, such as those associated with stress, immunological challenges, or the reproductive cycle. Neuronal substrates for prolactin-mediated sleep effects remain unknown; however, recent rodent sleep studies may provide insights into the potential sites of these effects.

在过去的50年里，催乳素在睡眠调节中的作用一直是广泛研究的主题，结果发现了这种激素的多种不同功能。泌乳素表现出一种特殊的昼夜节律释放模式，在黑暗时升高，在光照时降低。高催乳素水平与人类非快速眼动睡眠和脑电图δ波活动有关。相反，在啮齿动物的研究中，高催乳素血症与快速眼动睡眠有很强的相关性。催乳素可能与生殖周期中女性睡眠模式的改变有关，它可能在应激后快速眼动睡眠的增强和睡眠相关的免疫过程中发挥作用。总之，催乳素似乎有促进睡眠的作用，尤其是在黑暗阶段。然而，它似乎并没有在睡眠调节中发挥核心和连贯的作用，就像在一些神经肽如食欲素中观察到的那样。相反，它的主要功能可能是促进情境，但适应性，睡眠模式的变化，以应对具有挑战性的生理阶段，如与压力，免疫挑战或生殖周期相关的阶段。催乳素介导的睡眠效应的神经元底物尚不清楚；然而，最近的啮齿动物睡眠研究可能为这些影响的潜在部位提供见解。

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引用次数: 0

Alterations in resting-state EEG functional connectivity in patients with major depressive disorder receiving electroconvulsive therapy: A systematic review 接受电休克治疗的重度抑郁症患者静息状态脑电图功能连通性的改变：一项系统综述。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106017

Sarah Ulrich , Else Schneider , Gunnar Deuring , Saskia Erni , Magdalena Ridder , Jan Sarlon , Annette B. Brühl

Electroconvulsive therapy (ECT) is highly efficacious for the treatment of major depressive disorder (MDD), but its mechanisms still require clarification. Even though depression is associated with alterations in functional connectivity (FC), EEG studies investigating effects of ECT on FC have not been systematically reviewed. Understanding these effects may help to identify the role of functional brain circuits in depression and its remission. This systematic review aimed to synthesize EEG studies investigating FC changes in ECT-treated patients with depression. A systematic literature search was conducted following PRISMA guidelines. Peer-reviewed studies on pre-to post-ECT resting-state EEG FC changes in adult patients with MDD were included. Three of 143 studies were included, of which two reported reduced FC in the alpha and beta frequency bands and increased theta band FC in patients with ECT-treated MDD. Changes in alpha band FC were associated with treatment outcomes. Patients with MDD exhibit increased electrophysiological resting-state alpha band FC, particularly frontally, compared with healthy subjects. Thus, ECT-induced decrease might indicate a trend toward normalization of oscillatory brain rhythms. As brain oscillations have been proposed to be involved in neuronal synchronization, which is important for communication between networks, the potential restoration in patients with depression and the association of FC changes with clinical improvement may indicate a potential mechanism of action of ECT. Understanding ECT’s underlying mechanisms might ultimately enable treatment optimization, thus enhancing patient care. However, the number of studies is limited, with low-to-moderate EEG study quality, small sample sizes, and different electrophysiological FC measures.

电痉挛疗法（ECT）对重度抑郁症（MDD）的治疗非常有效，但其机制尚不清楚。尽管抑郁症与功能连通性（FC）的改变有关，但调查ECT对FC影响的脑电图研究尚未得到系统的回顾。了解这些影响可能有助于确定功能性脑回路在抑郁症及其缓解中的作用。本系统综述旨在综合研究ect治疗抑郁症患者FC变化的脑电图研究。按照PRISMA指南进行了系统的文献检索。同行评议的研究纳入了成年重度抑郁症患者ect前后静息状态脑电图FC变化。143项研究中有3项被纳入，其中2项报告了ect治疗的MDD患者α和β频带FC降低，θ频带FC增加。α带FC的变化与治疗结果相关。与健康受试者相比，重度抑郁症患者表现出更高的电生理静息状态α带FC，尤其是额叶。因此，ect诱导的减少可能表明振荡脑节律趋于正常化的趋势。由于脑振荡被认为参与神经元同步，而神经元同步对于神经网络之间的交流是重要的，抑郁症患者的电位恢复以及FC变化与临床改善的关联可能提示ECT的潜在作用机制。了解ECT的潜在机制可能最终使治疗优化，从而加强患者护理。然而，研究数量有限，脑电图研究质量低至中等，样本量小，电生理FC测量不同。

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引用次数: 0

Social cognition in autism and ADHD 自闭症和多动症的社会认知。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106022

Sven Bölte

Social cognition is a crucial capacity for social functioning. The last decades have seen a plethora of social cognition research in neurodevelopmental conditions, foremost autism and, to a lesser extent, ADHD, both characterized by social challenges. Social cognition is a multifaceted construct comprising various overlapping subdomains, such as Theory of Mind/mentalizing, emotion recognition, and social perception. Mechanisms underpinning social cognition are complex, including implicit and explicit, cognitive and affective, and hyper- and hypo-social information processing. This review explores the intricacies of social cognition in the context of autism and ADHD. Research indicates altered performance on social cognition tests in autism, compared to neurotypical groups, with social cognition alterations having a small but robust effect on the defining features of autism. The nature of such alterations in autism appears primarily in relation to implicit processing. ADHD groups show intermediate social cognition performance, appearing to be influenced by executive function difficulties. Social cognition varies with intellectual and verbal abilities and seems to improve with age in autism and ADHD. Social skills interventions in autism, and stimulant medication in ADHD have been shown to improve social cognition test performance, while mentalizing training effects in autism are less conclusive. A limitation of the field is that social cognition constructs and tests are not well delineated. Further, most research has been embedded in a nativist approach rather than a constructivist approach. The former has been questioned for ignoring environmental contributions, especially the dimension of mutual miscommunication between neurodivergent and neurotypical individuals.

社会认知是社会功能的一项重要能力。在过去的几十年里，我们看到了大量的神经发育条件下的社会认知研究，最重要的是自闭症，以及较小程度上的多动症，两者都以社会挑战为特征。社会认知是一个多层面的结构，包括心理理论/心理化、情感识别和社会感知等多个重叠的子领域。社会认知的机制是复杂的，包括内隐和外显、认知和情感、超社会和准社会信息加工。这篇综述探讨了自闭症和多动症背景下社会认知的复杂性。研究表明，与神经正常组相比，自闭症患者在社会认知测试中的表现有所改变，社会认知的改变对自闭症的定义特征有很小但很明显的影响。自闭症中这种改变的本质主要与内隐加工有关。ADHD组表现出中等的社会认知表现，似乎受到执行功能困难的影响。社会认知随着智力和语言能力的变化而变化，自闭症和多动症患者的社会认知似乎随着年龄的增长而提高。自闭症患者的社会技能干预和多动症患者的兴奋剂药物已被证明可以提高社会认知测试的表现，而自闭症患者的心智化训练效果则不那么确凿。该领域的一个局限性是社会认知结构和测试没有很好地描述。此外，大多数研究都采用了本土主义的方法，而不是建构主义的方法。前者因忽视了环境因素而受到质疑，尤其是神经分化个体和神经典型个体之间的相互误解。

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引用次数: 0

Plexins: Navigating through the neural regulation and brain pathology 丛神经：通过神经调节和脑病理导航。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105999

Ariba Khan , Poonam Sharma , Sarthak Dahiya , Bhupesh Sharma

Plexins are a family of transmembrane receptors known for their diverse roles in neural development, axon guidance, neuronal migration, synaptogenesis, and circuit formation. Semaphorins are a class of secreted and membrane proteins that act as primary ligands for plexin receptors. Semaphorins play a crucial role in central nervous system (CNS) development by regulating processes such as axonal growth, neuronal positioning, and synaptic connectivity. Various types of semaphorins like sema3A, sema4A, sema4C, sema4D, and many more have a crucial role in developing brain diseases. Likewise, various evidence suggests that plexin receptors are of four types: plexin A, plexin B, plexin C, and plexin D. Plexins have emerged as crucial regulators of neurogenesis and neuronal development and connectivity. When bound to semaphorins, these receptors trigger two major networking cascades, namely Rho and Ras GTPase networks. Dysregulation of plexin networking has been implicated in a myriad of brain disorders, including autism spectrum disorder (ASD), Schizophrenia, Alzheimer's disease (AD), Parkinson's disease (PD), and many more. This review synthesizes findings from molecular, cellular, and animal model studies to elucidate the mechanisms by which plexins contribute to the pathogenesis of various brain diseases.

丛蛋白是一个跨膜受体家族，在神经发育、轴突引导、神经元迁移、突触发生和电路形成中发挥着不同的作用。信号蛋白是一类分泌蛋白和膜蛋白，作为丛蛋白受体的初级配体。信号蛋白通过调节轴突生长、神经元定位和突触连接等过程在中枢神经系统（CNS）的发育中起着至关重要的作用。各种类型的信号蛋白，如sema3A、sema4A、sema4C、sema4D等，在脑部疾病的发生中起着至关重要的作用。同样，各种证据表明丛蛋白受体有四种类型：丛蛋白A、丛蛋白B、丛蛋白C和丛蛋白d。丛蛋白已成为神经发生、神经元发育和连通性的重要调节因子。当与信号蛋白结合时，这些受体触发两个主要的网络级联反应，即Rho和Ras GTPase网络。神经丛蛋白网络失调与许多脑部疾病有关，包括自闭症谱系障碍（ASD）、精神分裂症、阿尔茨海默病（AD）、帕金森病（PD）等等。本文综合了分子、细胞和动物模型研究的结果，阐明了丛蛋白参与各种脑部疾病发病的机制。

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引用次数: 0

Group-to-individual generalizability and individual-level inferences in cognitive neuroscience

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106024

Matthew Mattoni , Aaron J. Fisher , Kathleen M. Gates , Jason Chein , Thomas M. Olino

Much of cognitive neuroscience research is focused on group-averages and interindividual brain-behavior associations. However, many theories core to the goal of cognitive neuroscience, such as hypothesized neural mechanisms for a behavior, are inherently based on intraindividual processes. To accommodate this mismatch between study design and theory, research frequently relies on an implicit assumption that group-level, between-person inferences extend to individual-level, within-person processes. The assumption of group-to-individual generalizability, formally referred to as ergodicity, requires that a process be both homogenous within a population and stationary within individuals over time. Our goal in this review is to assess this assumption and provide an accessible introduction to idiographic science (study of the individual) for the cognitive neuroscientist, ultimately laying a foundation for increased focus on the study of intraindividual processes. We first review the history of idiographic science in psychology to connect this longstanding literature with recent individual-level research goals in cognitive neuroscience. We then consider two requirements of group-to-individual generalizability, pattern homogeneity and stationarity, and suggest that most processes in cognitive neuroscience do not meet these assumptions. Consequently, interindividual findings are inappropriate for the intraindividual inferences that many theories are based on. To address this challenge, we suggest precision imaging as an ideal path forward for intraindividual study and present a research framework for complementary interindividual and intraindividual study.

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引用次数: 0

Fear and safety learning in anxiety- and stress-related disorders: An updated meta-analysis 焦虑和压力相关障碍的恐惧和安全学习：一项更新的荟萃分析。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105983

Franziska M. Kausche , Hannes P. Carsten , Kim M. Sobania , Anja Riesel

Fear learning processes are believed to play a crucial role in the development and maintenance of anxiety and stress-related disorders. To integrate results across different studies, we conducted a systematic meta-analysis following PRISMA guidelines to examine differences in fear conditioning during fear acquisition, extinction, and extinction recall between individuals with anxiety-related or stress-related disorders and healthy participants. This analysis updates the work of Duits et al. (2015) while also refining distinctions between physiological and behavioral outcomes and examining extinction recall. Our meta-analysis encompasses 77 studies published from 1986 to 2022, involving 2052 patients with anxiety disorders, obsessive-compulsive disorder, or post-traumatic stress disorder, and 3258 healthy controls. The results indicate significant differences in fear acquisition, extinction, and recall between the two groups. Specifically, during acquisition patients exhibited heightened physiological and behavioral responses to the CS- and reported increased affect ratings for the CS+ . During extinction and extinction recall, patients continue to show heightened threat expectancy and negative affect ratings towards the CS- and increased affect ratings towards the CS+ . No differences were found in CS+ /CS- differentiation between groups. These findings imply that individuals with anxiety and stress-related disorders may exhibit amplified responses to safety cues and stronger reactions to threat cues during fear conditioning, lasting through extinction and extinction recall. These changes may lead to increased sensitivity in detecting fear and slower extinction process, resulting in more enduring anxiety responses. We discuss these results in the context of existing literature on fear and safety learning and consider potential underlying mechanisms.

恐惧学习过程被认为在焦虑和压力相关疾病的发展和维持中起着至关重要的作用。为了整合不同研究的结果，我们根据PRISMA指南进行了系统的荟萃分析，以检查焦虑相关或压力相关障碍个体与健康参与者在恐惧习得、消退和消退回忆期间的恐惧条件反射的差异。该分析更新了Duits等人（2015）的工作，同时也细化了生理和行为结果之间的区别，并检查了灭绝回忆。我们的荟萃分析包括从1986年到2022年发表的77项研究，涉及2052名患有焦虑症、强迫症或创伤后应激障碍的患者，以及3258名健康对照。结果表明，两组在恐惧习得、消退和回忆方面存在显著差异。具体来说，在习得过程中，患者对CS-表现出更高的生理和行为反应，并报告了CS+的影响评级增加。在消退和消退回忆过程中，患者继续表现出更高的威胁预期和对CS-的负面影响评分，以及对CS+的负面影响评分。各组间CS+/CS-分化无差异。这些发现表明，焦虑和压力相关障碍的个体在恐惧条件反射过程中可能对安全线索表现出放大的反应，对威胁线索表现出更强的反应，并持续到消退和消退回忆。这些变化可能导致检测恐惧的敏感性增加，消除过程减慢，从而导致更持久的焦虑反应。我们在现有的关于恐惧和安全学习的文献背景下讨论这些结果，并考虑潜在的潜在机制。

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引用次数: 0

Could sleep be a brain/cognitive/neural reserve-builder factor? A systematic review on the cognitive effects of sleep modulation in animal models 睡眠可能是大脑/认知/神经储备的构建因素吗？睡眠调节对动物认知影响的系统综述。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106015

Francesca Balsamo , Debora Meneo , Erica Berretta , Chiara Baglioni , Francesca Gelfo

The brain/cognitive/neural reserve concept suggests that lifelong experiences, from early life through adulthood, make the brain more resilient to neuronal damage. Modifiable lifestyle factors, such as sleep, can support the development and enhance such a reserve, helping to counteract age- or disease-related brain changes and their impact on cognition. Sleep plays a crucial role in cognitive functioning, and disruptions or disorders may increase neurodegenerative risks. This systematic review aims to explore how functional and disturbed sleep impacts cognitive functions and neuromorphological mechanisms in rodents, aiming to better understand its role in brain/cognitive/neural reserve development. This systematic review, registered on PROSPERO (ID: CRD42023423901) and conducted according to PRISMA-P guidelines, searched PubMed, Scopus, Web of Science, and Embase databases for studies up to June 2022, with terms related to sleep, rodents, and cognitive functions. Of the 28,666 articles identified, 142 met the inclusion criteria. Main results showed significant cognitive decline after sleep deprivation, especially in memory performance. These findings supports the importance of sleep as a critical factor in modulating brain/cognitive/neural reserve.

大脑/认知/神经储备概念表明，从早期生活到成年的终身经历，使大脑更能适应神经元损伤。可改变的生活方式因素，如睡眠，可以支持这种储备的发展和增强，有助于抵消与年龄或疾病相关的大脑变化及其对认知的影响。睡眠在认知功能中起着至关重要的作用，睡眠中断或紊乱可能会增加神经退行性疾病的风险。本文旨在探讨功能性睡眠和睡眠障碍如何影响啮齿动物的认知功能和神经形态学机制，以更好地了解其在脑/认知/神经储备发育中的作用。该系统综述在PROSPERO （ID: CRD42023423901）上注册，并根据PRISMA-P指南进行，检索了PubMed、Scopus、Web of Science和Embase数据库，检索了截至2022年6月的与睡眠、啮齿动物和认知功能相关的研究。在确定的28,666篇文章中，有142篇符合纳入标准。主要结果显示，睡眠剥夺后认知能力明显下降，尤其是记忆能力下降。这些发现支持了睡眠作为调节大脑/认知/神经储备的关键因素的重要性。

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引用次数: 0

Principles governing the effects of sensory loss on human abilities: An integrative review 控制感觉丧失对人类能力影响的原则：综合综述。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105986

Andrew J. Kolarik , Brian C.J. Moore

Blindness or deafness can significantly influence sensory abilities in intact modalities, affecting communication, orientation and navigation. Explanations for why certain abilities are enhanced and others degraded include: crossmodal cortical reorganization enhances abilities by providing additional neural processing resources; and sensory processing is impaired for tasks where calibration from the normally intact sense is required for good performance. However, these explanations are often specific to tasks or modalities, not accounting for why task-dependent enhancement or degradation are observed. This paper investigates whether sensory systems operate according to a theoretical framework comprising seven general principles (the perceptual restructuring hypothesis) spanning the various modalities. These principles predict whether an ability will be enhanced or degraded following sensory loss. Evidence from a wide range of studies is discussed, to assess the validity of the principles across different combinations of impaired sensory modalities (deafness or blindness) and intact modalities (vision, audition, touch, olfaction). It is concluded that sensory systems do operate broadly according to the principles of the framework, but with some exceptions.

失明或耳聋会严重影响完整形态下的感觉能力，影响沟通、定向和导航。对于为什么某些能力增强而另一些能力退化的解释包括：跨模态皮层重组通过提供额外的神经处理资源来增强能力；在需要从正常完整的感觉中进行校准以获得良好表现的任务中，感觉处理受到损害。然而，这些解释通常是针对任务或模式的，而不是解释为什么会观察到任务相关的增强或退化。本文研究了感觉系统是否根据一个理论框架运作，该框架包括七个一般原则（感知重构假说），跨越各种模式。这些原则预测了一种能力在失去感觉后是会增强还是会退化。本文讨论了来自广泛研究的证据，以评估这些原则在受损感觉模式（耳聋或失明）和完整感觉模式（视觉、听觉、触觉、嗅觉）的不同组合中的有效性。结论是，感觉系统确实根据框架的原则广泛地运作，但也有一些例外。

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引用次数: 0

From feeling chilly to burning up: How thermal signals shape the physiological state of the body and impact physical, emotional, and social well-being 从感觉寒冷到燃烧：热信号如何塑造身体的生理状态，并影响身体，情感和社会福祉。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105992

Alisha Vabba , Marina Scattolin , Giuseppina Porciello , Maria Serena Panasiti , Salvatore Maria Aglioti

This review examines the role of thermal interoception—awareness of body temperature—in shaping physiological states and its impact on physical, emotional, and social well-being. We describe the neural pathways and mechanisms involved in thermal processing and environmental heat exchange and how thermal interoception influences both autonomic and behavioral responses, contributing to survival and homeostasis. Additionally, the review highlights the significance of thermal signals and thermoregulation in determining higher-order cognitive and emotional functions, such as regulating sleep patterns and activity levels, monitoring physical well-being, regulating emotions, and even social interactions. We describe the existing instruments for assessing body temperature and thermal awareness and call for further research to investigate the role of thermal interoception in emotional and social domains. We also discuss potential therapeutic applications, particularly in the context of psychosomatic and neurological disorders characterized by emotional dysregulation, disrupted sleep and mood patterns, social difficulties, and alterations in self-consciousness.

这篇综述探讨了热内感受（体温感知）在形成生理状态中的作用及其对身体、情绪和社会福祉的影响。我们描述了涉及热处理和环境热交换的神经通路和机制，以及热内感受如何影响自主和行为反应，促进生存和体内平衡。此外，该综述强调了热信号和体温调节在决定高阶认知和情感功能方面的重要性，例如调节睡眠模式和活动水平，监测身体健康，调节情绪，甚至社会互动。我们描述了现有的评估体温和热意识的工具，并呼吁进一步研究热内感受在情绪和社会领域的作用。我们还讨论了潜在的治疗应用，特别是在以情绪失调、睡眠和情绪模式中断、社交困难和自我意识改变为特征的心身和神经疾病的背景下。

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引用次数: 0