Neuroscience and Biobehavioral Reviews最新文献_第3页

Gray matter atrophy and structural connectivity in Posterior Cortical Atrophy: A voxel-based meta-analysis 脑后皮质萎缩中的灰质萎缩和结构连接：基于体素的荟萃分析。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-28 DOI: 10.1016/j.neubiorev.2026.106554

Daniele Licciardo , Chiara Matti , Alberto Benelli , Valeria Isella , Ildebrando Appollonio , Emiliano Santarnecchi

Posterior Cortical Atrophy (PCA) is a neurodegenerative syndrome most commonly associated with Alzheimer’s disease, characterized by progressive visuospatial and visuoperceptual decline. Although voxel-based morphometry studies have described gray matter loss in PCA, a comprehensive and updated coordinate-based meta-analysis is still missing, and associated structural connectivity alterations remain unclear. We conducted a systematic review and meta-analysis of whole-brain voxel-based morphometry studies comparing patients with PCA and healthy controls (PROSPERO ID: CRD420251010673). Analyses were performed using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) with family-wise error correction, and meta-regressions assessed the impact of demographic and clinical variables. To investigate structural connectivity, deterministic tractography was carried out on a normative diffusion MRI template, using meta-analytic gray matter clusters as seeds. Eighteen studies were included (339 PCA; 577 healthy controls). The meta-analysis revealed consistent bilateral gray matter atrophy in the lateral occipital cortex, inferior parietal lobule, precuneus, and ventral occipitotemporal regions. Meta-regression highlighted an interaction between age and disease duration, associated with atrophy in the left superior temporal gyrus and right thalamus. Tractography demonstrated that affected clusters were embedded within major long-range pathways, including the superior and inferior longitudinal fasciculi, vertical occipital fasciculi, and parietal aslant tract. Regression-derived clusters additionally mapped onto the arcuate fasciculus, frontal aslant tract, and superior thalamic radiations. This is the first systematic review and voxel-based meta-analysis of PCA conducted after the establishment of consensus diagnostic criteria, providing a statistically robust characterization of gray and white matter alterations and identifying potential imaging biomarkers for diagnosis and treatment.

后皮质萎缩（PCA）是一种最常与阿尔茨海默病相关的神经退行性综合征，其特征是进行性视觉空间和视觉感觉衰退。尽管基于体素的形态测量学研究已经描述了PCA中的灰质损失，但基于坐标的综合和更新的元分析仍然缺失，相关的结构连接改变仍然不清楚。我们对基于全脑体素的形态学研究进行了系统回顾和荟萃分析，比较了PCA患者和健康对照（PROSPERO ID: CRD420251010673）。采用基于种子的受试者图像排列映射（SDM-PSI）进行分析，并进行家庭误差校正，并进行meta回归评估人口统计学和临床变量的影响。为了研究结构连通性，在规范的扩散MRI模板上进行了确定性神经束造影，使用元分析灰质簇作为种子。纳入18项研究（339例PCA， 577例健康对照）。荟萃分析显示，双侧枕侧皮质、下顶叶、楔前叶和枕颞腹侧灰质萎缩一致。荟萃回归强调了年龄和疾病持续时间之间的相互作用，与左侧颞上回和右侧丘脑的萎缩有关。神经束造影显示，受影响的神经簇位于主要的远程神经通路内，包括上、下纵束、垂枕束和顶骨斜束。回归衍生的簇还映射到弓状束、额斜束和丘脑上辐射。这是建立共识诊断标准后首次对PCA进行系统回顾和基于体素的荟萃分析，提供了统计上可靠的灰质和白质改变特征，并确定了诊断和治疗的潜在成像生物标志物。

{"title":"Gray matter atrophy and structural connectivity in Posterior Cortical Atrophy: A voxel-based meta-analysis","authors":"Daniele Licciardo , Chiara Matti , Alberto Benelli , Valeria Isella , Ildebrando Appollonio , Emiliano Santarnecchi","doi":"10.1016/j.neubiorev.2026.106554","DOIUrl":"10.1016/j.neubiorev.2026.106554","url":null,"abstract":"<div><div>Posterior Cortical Atrophy (PCA) is a neurodegenerative syndrome most commonly associated with Alzheimer’s disease, characterized by progressive visuospatial and visuoperceptual decline. Although voxel-based morphometry studies have described gray matter loss in PCA, a comprehensive and updated coordinate-based meta-analysis is still missing, and associated structural connectivity alterations remain unclear. We conducted a systematic review and meta-analysis of whole-brain voxel-based morphometry studies comparing patients with PCA and healthy controls (PROSPERO ID: CRD420251010673). Analyses were performed using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) with family-wise error correction, and meta-regressions assessed the impact of demographic and clinical variables. To investigate structural connectivity, deterministic tractography was carried out on a normative diffusion MRI template, using meta-analytic gray matter clusters as seeds. Eighteen studies were included (339 PCA; 577 healthy controls). The meta-analysis revealed consistent bilateral gray matter atrophy in the lateral occipital cortex, inferior parietal lobule, precuneus, and ventral occipitotemporal regions. Meta-regression highlighted an interaction between age and disease duration, associated with atrophy in the left superior temporal gyrus and right thalamus. Tractography demonstrated that affected clusters were embedded within major long-range pathways, including the superior and inferior longitudinal fasciculi, vertical occipital fasciculi, and parietal aslant tract. Regression-derived clusters additionally mapped onto the arcuate fasciculus, frontal aslant tract, and superior thalamic radiations. This is the first systematic review and voxel-based meta-analysis of PCA conducted after the establishment of consensus diagnostic criteria, providing a statistically robust characterization of gray and white matter alterations and identifying potential imaging biomarkers for diagnosis and treatment.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106554"},"PeriodicalIF":7.9,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological substrates of structure-function coupling in brain networks 脑网络结构-功能耦合的生物学基础。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-27 DOI: 10.1016/j.neubiorev.2026.106581

Panagiotis Fotiadis , Amy F.T. Arnsten , Linden Parkes , Theodore D. Satterthwaite , Russell T. Shinohara , Dani S. Bassett

In this review, we draw insight from the fields of neurobiology and computational neuroscience to address a fundamental question: Why does the correlation between structural and functional connectivity vary across the human cortex? We begin by summarizing empirical studies that reveal the heterogeneous expression of structure-function coupling across brain regions and among individuals. We then identify potential biological factors that mediate this variability, focusing on the roles of evolution, myeloarchitecture, cytoarchitecture, and neuromodulation in sculpting the dynamic and diverse structure-function landscape of the human cortex. We next turn to computational modeling to deepen our understanding of the relationship between a system’s structural architecture and functional expression. We investigate biologically inspired computational models that map structure to function in human brain networks, paying special attention to studies that simulate external perturbations and structural lesions, and discuss the insights these approaches offer into the causal mechanisms governing the heterogeneous interplay between structural and functional connectivity. We close with a discussion of future directions, emphasizing efforts to bridge neurobiology and computational modeling to design biologically accurate, individualized models of the human brain. In particular, we highlight the potential of multi-layered networks informed by individual-specific microstructural and neuromodulatory gradients and governed by non-linear dynamics as a particularly fruitful direction. Such personalized models accounting for the synergistic effects of biological gradients could be experimentally validated to assess their predictive efficacy, ultimately bringing us one step closer to non-invasive, connectome-based clinical treatments tailored to the individual.

在这篇综述中，我们借鉴了神经生物学和计算神经科学领域的见解，以解决一个基本问题：为什么结构和功能连接之间的相关性在人类皮层中有所不同？我们首先总结了揭示结构-功能耦合在大脑区域和个体之间异质表达的实证研究。然后，我们确定了介导这种变异性的潜在生物因素，重点关注进化、骨髓结构、细胞结构和神经调节在塑造人类皮层动态和多样化结构-功能景观中的作用。接下来，我们转向计算建模，以加深我们对系统结构架构和功能表达之间关系的理解。我们研究了生物学启发的计算模型，这些模型将人类大脑网络的结构映射到功能，特别关注模拟外部扰动和结构病变的研究，并讨论了这些方法对控制结构和功能连接之间异质性相互作用的因果机制的见解。最后，我们讨论了未来的发展方向，强调了神经生物学和计算建模之间的桥梁，以设计生物学上准确的、个性化的人类大脑模型。特别是，我们强调了由个体特异性微观结构和神经调节梯度以及非线性动力学控制的多层网络的潜力，这是一个特别富有成果的方向。这种考虑生物梯度协同效应的个性化模型可以通过实验验证来评估其预测效果，最终使我们更接近为个体量身定制的无创、基于连接体的临床治疗。

{"title":"Biological substrates of structure-function coupling in brain networks","authors":"Panagiotis Fotiadis , Amy F.T. Arnsten , Linden Parkes , Theodore D. Satterthwaite , Russell T. Shinohara , Dani S. Bassett","doi":"10.1016/j.neubiorev.2026.106581","DOIUrl":"10.1016/j.neubiorev.2026.106581","url":null,"abstract":"<div><div>In this review, we draw insight from the fields of neurobiology and computational neuroscience to address a fundamental question: Why does the correlation between structural and functional connectivity vary across the human cortex? We begin by summarizing empirical studies that reveal the heterogeneous expression of structure-function coupling across brain regions and among individuals. We then identify potential biological factors that mediate this variability, focusing on the roles of evolution, myeloarchitecture, cytoarchitecture, and neuromodulation in sculpting the dynamic and diverse structure-function landscape of the human cortex. We next turn to computational modeling to deepen our understanding of the relationship between a system’s structural architecture and functional expression. We investigate biologically inspired computational models that map structure to function in human brain networks, paying special attention to studies that simulate external perturbations and structural lesions, and discuss the insights these approaches offer into the causal mechanisms governing the heterogeneous interplay between structural and functional connectivity. We close with a discussion of future directions, emphasizing efforts to bridge neurobiology and computational modeling to design biologically accurate, individualized models of the human brain. In particular, we highlight the potential of multi-layered networks informed by individual-specific microstructural and neuromodulatory gradients and governed by non-linear dynamics as a particularly fruitful direction. Such personalized models accounting for the synergistic effects of biological gradients could be experimentally validated to assess their predictive efficacy, ultimately bringing us one step closer to non-invasive, connectome-based clinical treatments tailored to the individual.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"184 ","pages":"Article 106581"},"PeriodicalIF":7.9,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurocircuitry of gait: Brainstem integration of rhythmicity and goal-directed behavior in normal and pathological states 步态的神经回路：正常和病理状态下节律性和目标导向行为的脑干整合。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-27 DOI: 10.1016/j.neubiorev.2026.106577

Nahal Farhani , Tony Szturm , Douglas E. Hobson

This review explores the pivotal role of the brainstem in regulating gait, highlighting its function in modulating the balance between rhythmic motor patterns and goal-directed behaviors. Gait is a voluntary motor behavior that involves the continuous interplay of rhythmic motor control and higher-order cognitive processes. Key brainstem structures, including the pedunculopontine nucleus (PPN), dorsal raphe nucleus (DRN), and gigantocellular nucleus (GiN), integrate sensory inputs, motivational states, and contextual cues to modulate locomotion. These nuclei maintain efficient motor adaptation and conserve cognitive resources by coordinating brainstem and spinal cord circuitry (i.e., central pattern generators) which “automate” the control of muscles that produce the rhythmical locomotor behaviors. While this review primarily focuses on these three key nuclei, it also briefly discusses additional brainstem structures involved in gait and postural control, such as the vestibular nuclei, red nucleus, and inferior olive. Disruptions in the brainstem networks due to neurodegenerative diseases like Parkinson’s disease and aging impair the ability to adjust the level of cognitive control required for gait, necessitating increased cognitive effort for motor and balance regulation. By presenting a hierarchical model of gait control, this review provides insight into the dynamic interplay between brainstem, spinal pattern generators, and cortical systems in locomotion control.

这篇综述探讨了脑干在调节步态中的关键作用，强调了它在调节节律运动模式和目标导向行为之间的平衡中的功能。步态是一种自发的运动行为，涉及节律性运动控制和高阶认知过程的持续相互作用。关键的脑干结构，包括桥脚核（PPN）、中缝背核（DRN）和巨细胞核（GiN），整合感觉输入、动机状态和情境线索来调节运动。这些核通过协调脑干和脊髓回路（即中枢模式发生器）来保持有效的运动适应和保护认知资源，从而“自动”控制产生有节奏运动行为的肌肉。虽然这篇综述主要关注这三个关键核，但它也简要讨论了涉及步态和姿势控制的其他脑干结构，如前庭核、红核和下橄榄核。帕金森氏症等神经退行性疾病和衰老导致脑干网络中断，损害了调节步态所需的认知控制水平的能力，需要增加运动和平衡调节的认知努力。通过提出步态控制的层次模型，本综述提供了脑干、脊髓模式发生器和皮层系统在运动控制中的动态相互作用的见解。

{"title":"Neurocircuitry of gait: Brainstem integration of rhythmicity and goal-directed behavior in normal and pathological states","authors":"Nahal Farhani , Tony Szturm , Douglas E. Hobson","doi":"10.1016/j.neubiorev.2026.106577","DOIUrl":"10.1016/j.neubiorev.2026.106577","url":null,"abstract":"<div><div>This review explores the pivotal role of the brainstem in regulating gait, highlighting its function in modulating the balance between rhythmic motor patterns and goal-directed behaviors. Gait is a voluntary motor behavior that involves the continuous interplay of rhythmic motor control and higher-order cognitive processes. Key brainstem structures, including the pedunculopontine nucleus (PPN), dorsal raphe nucleus (DRN), and gigantocellular nucleus (GiN), integrate sensory inputs, motivational states, and contextual cues to modulate locomotion. These nuclei maintain efficient motor adaptation and conserve cognitive resources by coordinating brainstem and spinal cord circuitry (i.e., central pattern generators) which “automate” the control of muscles that produce the rhythmical locomotor behaviors. While this review primarily focuses on these three key nuclei, it also briefly discusses additional brainstem structures involved in gait and postural control, such as the vestibular nuclei, red nucleus, and inferior olive. Disruptions in the brainstem networks due to neurodegenerative diseases like Parkinson’s disease and aging impair the ability to adjust the level of cognitive control required for gait, necessitating increased cognitive effort for motor and balance regulation. By presenting a hierarchical model of gait control, this review provides insight into the dynamic interplay between brainstem, spinal pattern generators, and cortical systems in locomotion control.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106577"},"PeriodicalIF":7.9,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsic brain activity and multiscale mechanisms of auditory verbal hallucinations in schizophrenia: A systematic review and meta-analysis 精神分裂症患者听觉言语幻觉的内在脑活动和多尺度机制：系统回顾和荟萃分析。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-26 DOI: 10.1016/j.neubiorev.2026.106579

Yuanjun Xie , Tian Zhang , Anping Ouyang , Guan Muzhen , Xinxin Lin , Lingling Wang , Xuqian Diao , Yijun Li , Wei He , Qianqian Dong , Ling-li Zeng , Chenxi Li , Huaning Wang , Peng Fang

Auditory verbal hallucinations (AVH) represent one of the most debilitating symptoms in schizophrenia. The amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF), derived from resting-state fMRI, serve as robust metrics for intrinsic brain activity; however, the network-level architecture and biological substrates underlying AVH-related ALFF/fALFF alternations have not yet been systematically elucidated. In this study, we conducted a comprehensive systematic review and meta-analysis of ALFF/fALFF studies in schizophrenia patients with AVH, integrating neurochemical mapping and transcriptomic annotation to provide a multilevel mechanistic perspective. Across studies, AVH were consistently associated with increased intrinsic activity in auditory and language networks, reward and motivation circuits, and executive control regions, along with decreased activity within sensorimotor network, whereas alternations within default mode network regions were more heterogeneous. Meta-analysis further highlighted the involvement of thalamic-frontal circuitry in distinguishing AVH patients from non-AVH patients. Spatial correlation analysis demonstrated significant coupling between AVH-related functional changes and the normaltive distribution of key neurotransmitter systems, including the cannabinoid (CB1), dopaminergic (D2), noradrenergic (NAT), and metabotropic glutamate (mGluR5) . Gene enrichment analysis additionally revealed that implicated regions were transcriptionally characterized by biological pathways related to neurodevelopment, neural circuit formation, and regulation of neural excitability. By integrating these convergent results, we propose a systems-level model in which early genetic and neurodevelopmental vulnerabilities interacts with ongoing neurotransmitter dysregulation and large-scale network dysfunction, ultimately driving the emergence and persistence of AVH in schizophrenia. These findings underscore the importance of multidimensional biomarkers and may inform the development of precision interventions targeting hallucinations in schizophrenia.

听觉言语幻觉（AVH）是精神分裂症中最令人衰弱的症状之一。低频波动幅度（ALFF）和分数ALFF (fALFF)，来自静息状态的功能磁共振成像，作为内在大脑活动的稳健指标；然而，avh相关的ALFF/fALFF变化的网络级结构和生物底物尚未被系统地阐明。在这项研究中，我们对精神分裂症合并AVH患者的ALFF/fALFF研究进行了全面的系统回顾和荟萃分析，结合神经化学作图和转录组注释，提供了一个多层次的机制视角。在所有研究中，AVH始终与听觉和语言网络、奖励和动机回路以及执行控制区域的内在活动增加有关，同时与感觉运动网络的活动减少有关，而默认模式网络区域的变化则更为异质性。meta分析进一步强调了丘脑-额叶回路在区分AVH患者和非AVH患者中的作用。空间相关分析表明，avh相关的功能变化与大麻素（CB1）、多巴胺能（D2）、去甲肾上腺素能（NAT）和代谢性谷氨酸（mGluR5）等关键神经递质系统的正态分布存在显著耦合。基因富集分析还揭示了与神经发育、神经回路形成和神经兴奋性调节相关的生物学通路的转录特征。通过整合这些结果，我们提出了一个系统级模型，其中早期遗传和神经发育脆弱性与持续的神经递质失调和大规模网络功能障碍相互作用，最终驱动精神分裂症AVH的出现和持续。这些发现强调了多维生物标志物的重要性，并可能为发展针对精神分裂症幻觉的精确干预提供信息。

{"title":"Intrinsic brain activity and multiscale mechanisms of auditory verbal hallucinations in schizophrenia: A systematic review and meta-analysis","authors":"Yuanjun Xie , Tian Zhang , Anping Ouyang , Guan Muzhen , Xinxin Lin , Lingling Wang , Xuqian Diao , Yijun Li , Wei He , Qianqian Dong , Ling-li Zeng , Chenxi Li , Huaning Wang , Peng Fang","doi":"10.1016/j.neubiorev.2026.106579","DOIUrl":"10.1016/j.neubiorev.2026.106579","url":null,"abstract":"<div><div>Auditory verbal hallucinations (AVH) represent one of the most debilitating symptoms in schizophrenia. The amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF), derived from resting-state fMRI, serve as robust metrics for intrinsic brain activity; however, the network-level architecture and biological substrates underlying AVH-related ALFF/fALFF alternations have not yet been systematically elucidated. In this study, we conducted a comprehensive systematic review and meta-analysis of ALFF/fALFF studies in schizophrenia patients with AVH, integrating neurochemical mapping and transcriptomic annotation to provide a multilevel mechanistic perspective. Across studies, AVH were consistently associated with increased intrinsic activity in auditory and language networks, reward and motivation circuits, and executive control regions, along with decreased activity within sensorimotor network, whereas alternations within default mode network regions were more heterogeneous. Meta-analysis further highlighted the involvement of thalamic-frontal circuitry in distinguishing AVH patients from non-AVH patients. Spatial correlation analysis demonstrated significant coupling between AVH-related functional changes and the normaltive distribution of key neurotransmitter systems, including the cannabinoid (CB1), dopaminergic (D2), noradrenergic (NAT), and metabotropic glutamate (mGluR5) . Gene enrichment analysis additionally revealed that implicated regions were transcriptionally characterized by biological pathways related to neurodevelopment, neural circuit formation, and regulation of neural excitability. By integrating these convergent results, we propose a systems-level model in which early genetic and neurodevelopmental vulnerabilities interacts with ongoing neurotransmitter dysregulation and large-scale network dysfunction, ultimately driving the emergence and persistence of AVH in schizophrenia. These findings underscore the importance of multidimensional biomarkers and may inform the development of precision interventions targeting hallucinations in schizophrenia.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106579"},"PeriodicalIF":7.9,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antithrombotic agents in the treatment of severe mental illness: A systematic review and meta-analysis of randomized controlled trials 抗血栓药物治疗严重精神疾病：随机对照试验的系统回顾和荟萃分析。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-25 DOI: 10.1016/j.neubiorev.2026.106574

Caroline Fussing Bruun , Mette Ungermann Fredskild , Maria Faurholt-Jepsen , Maj Vinberg , Lars Vedel Kessing , Klaus Munkholm

Evidence suggests shared pathophysiologic mechanisms between severe mental illness (SMI) and cardiovascular disease (CVD). Drugs used for CVD, such as antithrombotic agents (ATAs), may therefore be repurposed for the treatment of SMI. We conducted the first systematic review and meta-analysis (PROSPERO registration CRD42024524420) of ATAs for SMI and reported results according to PRISMA guidelines. We searched MEDLINE, Embase, and PsycINFO (October 10, 2024) and performed random-effects meta-analysis. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool, and the certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework. Primary outcomes were symptom severity, risk of recurrence, and tolerability. We included 12 randomized trials investigating aspirin, cilostazol, and dipyridamole in a total of 742 patients with schizophrenia, major depression, and bipolar disorder. Results showed that ATA treatment may reduce depressive symptoms in patients with SMI (SMD −0.62; 95 % CI −1.11 to −0.13; 8 studies; very low-certainty evidence). Based on studies with low risk of bias, ATA treatment may reduce PANSS total score compared with placebo (SMD −0.57; 95 % CI −0.86 to −0.28; 3 studies; very low-certainty evidence). Tolerability of ATAs may not differ from placebo (RR 0.89; 95 % CI 0.57–1.40; 9 studies; very low-certainty evidence). Given the low certainty of the evidence, effect estimates should be interpreted with caution. The therapeutic potential of ATAs in SMI remains uncertain. Well-powered RCTs investigating clinically relevant outcomes in clearly defined populations are needed.

有证据表明，严重精神疾病（SMI）和心血管疾病（CVD）之间存在共同的病理生理机制。因此，用于心血管疾病的药物，如抗血栓药物（ATAs），可能会被重新用于治疗重度精神分裂症。我们对治疗SMI的ATAs进行了首次系统评价和荟萃分析（PROSPERO注册CRD42024524420），并根据PRISMA指南报告了结果。我们检索MEDLINE、Embase和PsycINFO（2024年10月10日），并进行随机效应荟萃分析。使用Cochrane Risk of bias 2工具评估偏倚风险，使用分级推荐、评估、发展和评价（GRADE）框架评估证据的确定性。主要结局是症状严重程度、复发风险和耐受性。我们纳入了12项随机试验，研究了742例精神分裂症、重度抑郁症和双相情感障碍患者的阿司匹林、西洛他唑和双嘧达莫。结果显示，ATA治疗可减轻重度精神分裂症患者的抑郁症状（SMD -0.62; 95% CI -1.11至-0.13；8项研究；极低确定性证据）。基于低偏倚风险的研究，与安慰剂相比，ATA治疗可能降低PANSS总分（SMD -0.57; 95% CI -0.86至-0.28；3项研究；极低确定性证据）。ATAs的耐受性可能与安慰剂没有差异（RR 0.89; 95% CI 0.57 - 1.40； 9项研究；极低确定性证据）。鉴于证据的低确定性，应谨慎解释效果估计。ATAs治疗重度精神分裂症的潜力仍不确定。需要在明确定义的人群中调查临床相关结果的可靠随机对照试验。

{"title":"Antithrombotic agents in the treatment of severe mental illness: A systematic review and meta-analysis of randomized controlled trials","authors":"Caroline Fussing Bruun , Mette Ungermann Fredskild , Maria Faurholt-Jepsen , Maj Vinberg , Lars Vedel Kessing , Klaus Munkholm","doi":"10.1016/j.neubiorev.2026.106574","DOIUrl":"10.1016/j.neubiorev.2026.106574","url":null,"abstract":"<div><div>Evidence suggests shared pathophysiologic mechanisms between severe mental illness (SMI) and cardiovascular disease (CVD). Drugs used for CVD, such as antithrombotic agents (ATAs), may therefore be repurposed for the treatment of SMI. We conducted the first systematic review and meta-analysis (PROSPERO registration CRD42024524420) of ATAs for SMI and reported results according to PRISMA guidelines. We searched MEDLINE, Embase, and PsycINFO (October 10, 2024) and performed random-effects meta-analysis. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool, and the certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework. Primary outcomes were symptom severity, risk of recurrence, and tolerability. We included 12 randomized trials investigating aspirin, cilostazol, and dipyridamole in a total of 742 patients with schizophrenia, major depression, and bipolar disorder. Results showed that ATA treatment may reduce depressive symptoms in patients with SMI (SMD −0.62; 95 % CI −1.11 to −0.13; 8 studies; very low-certainty evidence). Based on studies with low risk of bias, ATA treatment may reduce PANSS total score compared with placebo (SMD −0.57; 95 % CI −0.86 to −0.28; 3 studies; very low-certainty evidence). Tolerability of ATAs may not differ from placebo (RR 0.89; 95 % CI 0.57–1.40; 9 studies; very low-certainty evidence). Given the low certainty of the evidence, effect estimates should be interpreted with caution. The therapeutic potential of ATAs in SMI remains uncertain. Well-powered RCTs investigating clinically relevant outcomes in clearly defined populations are needed.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106574"},"PeriodicalIF":7.9,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146067881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain correlates of psychological trauma in chronic pain: A systematic review 慢性疼痛患者的心理创伤与大脑相关：系统综述。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-25 DOI: 10.1016/j.neubiorev.2026.106576

Tong En Lim , Eilish Fitzpatrick , Saurab Sharma , Nell Norman-Nott , Negin Hesam-Shariati , James H. McAuley , Aidan G. Cashin , Sylvia M. Gustin , Yann Quidé

Exposure to traumatic events is a risk factor for the development and maintenance of chronic pain. Similar morphological and functional brain alterations, including cognitive deficits, have been reported in studies of chronic pain and trauma. However, the brain changes associated with trauma exposure in chronic pain remain poorly understood. To understand this relationship, literature searches were conducted in three electronic databases. Eligible studies were observational and included adults with chronic pain, reported changes in brain morphology or function associated with trauma exposure in childhood or adulthood. Pairs of independent reviewers screened titles/abstracts and full-texts, and extracted data. Risk of bias was assessed using the Newcastle-Ottawa Scale and certainty of evidence was assessed using GRADE. Thirteen studies were included. Exposure to childhood adversity (n = 7; very low certainty evidence) was associated with morphological and functional alterations of the anterior cingulate cortex, superior frontal gyrus, hippocampus, insula, and regions pertaining to the broader salience network. Trauma exposure in adulthood (n = 6; very low certainty evidence) was associated with morphological and functional alterations in the hippocampus, insula, anterior/middle/posterior cingulate cortex and superior temporal gyrus. Trauma-related impairments in language, memory and overall cognitive functioning were reported in individuals with chronic pain exposed to either childhood or adulthood adverse experiences. The results indicated evidence for brain alterations associated with trauma exposure in people with chronic pain. Aberrant structure and activity in the salience and default mode networks may represent markers of later development of chronic pain post-trauma, pointing to the potential use of network-focused and emotion-targeted interventions.

暴露于创伤性事件是发展和维持慢性疼痛的危险因素。在慢性疼痛和创伤的研究中也有类似的脑形态和功能改变，包括认知缺陷。然而，与慢性疼痛创伤暴露相关的大脑变化仍然知之甚少。为了了解这种关系，我们在三个电子数据库中进行了文献检索。符合条件的研究是观察性的，包括患有慢性疼痛的成年人，报告的脑形态或功能变化与儿童或成年期创伤暴露有关。对独立审稿人筛选标题/摘要和全文，并提取数据。使用纽卡斯尔-渥太华量表评估偏倚风险，使用GRADE评估证据的确定性。纳入了13项研究。暴露于童年逆境（n=7；非常低确定性证据）与前扣带皮层、额上回、海马体、脑岛和与更广泛的突出网络相关的区域的形态和功能改变有关。成年期创伤暴露（n=6；极低确定性证据）与海马、岛、前/中/后扣带皮层和颞上回的形态和功能改变有关。据报道，患有慢性疼痛的人在童年或成年时期经历过不良经历，他们的语言、记忆和整体认知功能都会受到创伤相关的损害。研究结果表明，慢性疼痛患者的大脑变化与创伤暴露有关。突出和默认模式网络中的异常结构和活动可能代表创伤后慢性疼痛后期发展的标志，指出网络聚焦和情绪定向干预的潜在用途。

{"title":"Brain correlates of psychological trauma in chronic pain: A systematic review","authors":"Tong En Lim , Eilish Fitzpatrick , Saurab Sharma , Nell Norman-Nott , Negin Hesam-Shariati , James H. McAuley , Aidan G. Cashin , Sylvia M. Gustin , Yann Quidé","doi":"10.1016/j.neubiorev.2026.106576","DOIUrl":"10.1016/j.neubiorev.2026.106576","url":null,"abstract":"<div><div>Exposure to traumatic events is a risk factor for the development and maintenance of chronic pain. Similar morphological and functional brain alterations, including cognitive deficits, have been reported in studies of chronic pain and trauma. However, the brain changes associated with trauma exposure in chronic pain remain poorly understood. To understand this relationship, literature searches were conducted in three electronic databases. Eligible studies were observational and included adults with chronic pain, reported changes in brain morphology or function associated with trauma exposure in childhood or adulthood. Pairs of independent reviewers screened titles/abstracts and full-texts, and extracted data. Risk of bias was assessed using the Newcastle-Ottawa Scale and certainty of evidence was assessed using GRADE. Thirteen studies were included. Exposure to childhood adversity (n = 7; very low certainty evidence) was associated with morphological and functional alterations of the anterior cingulate cortex, superior frontal gyrus, hippocampus, insula, and regions pertaining to the broader salience network. Trauma exposure in adulthood (n = 6; very low certainty evidence) was associated with morphological and functional alterations in the hippocampus, insula, anterior/middle/posterior cingulate cortex and superior temporal gyrus. Trauma-related impairments in language, memory and overall cognitive functioning were reported in individuals with chronic pain exposed to either childhood or adulthood adverse experiences. The results indicated evidence for brain alterations associated with trauma exposure in people with chronic pain. Aberrant structure and activity in the salience and default mode networks may represent markers of later development of chronic pain post-trauma, pointing to the potential use of network-focused and emotion-targeted interventions.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106576"},"PeriodicalIF":7.9,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146067924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological moderators of psilocybin-assisted therapy in depression: A systematic review and meta-analysis 抑郁症裸盖菇素辅助治疗的方法学调节因素：系统回顾和荟萃分析。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-24 DOI: 10.1016/j.neubiorev.2026.106573

Omer A. Syed , Benjamin Tsang , Sean M. Nestor , Nir Lipsman , Muhammad Ishrat Husain , Fahad Alam , Peter Giacobbe

Psilocybin-assisted therapy (PAT) is an emerging intervention for depression. Though several clinical trials report promising results for PAT in treating depression, there remains a need for consensus on optimal methodologies and standardization of PAT protocols. The objective of this review was to assess the efficacy of PAT in treating depressive symptoms and to systematically examine the influence of methodological moderators underlying antidepressant responses. We searched the electronic databases of PubMed, MEDLINE, PsychInfo and Embase for randomized-controlled trials (RCTs) using PAT as a treatment intervention for major depressive disorder. The primary outcomes were standardized mean difference (SMD) of change in depressive symptoms pre- versus post-treatment sessions, and the difference in antidepressant treatment effects among various PAT methodologies in a subgroup analysis. Seven RCTs involving 522 participants were analyzed. The overall random effects model found PAT to have a large and significant antidepressant effect. The subgroup analyses found larger effects, albeit non-significant differences in subgroup heterogeneity, associated with studies that administered psilocybin in bodyweight-adjusted doses and provided longer preparation, dosing, and integration sessions and provided non-manualized psychotherapy. This study presents the first systematic examination of PAT methodologies influencing antidepressant effects and provides preliminary insights for clinicians in designing future PAT protocols for depression.

裸盖菇素辅助治疗（PAT）是一种新兴的抑郁症干预手段。尽管一些临床试验报告了PAT治疗抑郁症的有希望的结果，但仍需要对最佳方法和PAT协议的标准化达成共识。本综述的目的是评估PAT治疗抑郁症状的疗效，并系统地检查方法学调节因子对抗抑郁反应的影响。我们检索了PubMed、MEDLINE、PsychInfo和Embase的电子数据库，寻找使用PAT作为重度抑郁症治疗干预措施的随机对照试验（RCTs）。在亚组分析中，主要结果是治疗前后抑郁症状变化的标准化平均差异（SMD），以及不同PAT方法之间抗抑郁治疗效果的差异。共分析了7项随机对照试验，涉及522名受试者。整体随机效应模型发现PAT具有较大且显著的抗抑郁作用。亚组分析发现了更大的影响，尽管亚组异质性无显著差异，与以体重调整剂量给予裸盖菇素并提供更长的准备、给药和非人工心理治疗整合疗程的研究相关。本研究首次对影响抗抑郁药物效果的PAT方法进行了系统检查，并为临床医生设计未来抑郁症的PAT方案提供了初步见解。

{"title":"Methodological moderators of psilocybin-assisted therapy in depression: A systematic review and meta-analysis","authors":"Omer A. Syed , Benjamin Tsang , Sean M. Nestor , Nir Lipsman , Muhammad Ishrat Husain , Fahad Alam , Peter Giacobbe","doi":"10.1016/j.neubiorev.2026.106573","DOIUrl":"10.1016/j.neubiorev.2026.106573","url":null,"abstract":"<div><div>Psilocybin-assisted therapy (PAT) is an emerging intervention for depression. Though several clinical trials report promising results for PAT in treating depression, there remains a need for consensus on optimal methodologies and standardization of PAT protocols. The objective of this review was to assess the efficacy of PAT in treating depressive symptoms and to systematically examine the influence of methodological moderators underlying antidepressant responses. We searched the electronic databases of PubMed, MEDLINE, PsychInfo and Embase for randomized-controlled trials (RCTs) using PAT as a treatment intervention for major depressive disorder. The primary outcomes were standardized mean difference (SMD) of change in depressive symptoms pre- versus post-treatment sessions, and the difference in antidepressant treatment effects among various PAT methodologies in a subgroup analysis. Seven RCTs involving 522 participants were analyzed. The overall random effects model found PAT to have a large and significant antidepressant effect. The subgroup analyses found larger effects, albeit non-significant differences in subgroup heterogeneity, associated with studies that administered psilocybin in bodyweight-adjusted doses and provided longer preparation, dosing, and integration sessions and provided non-manualized psychotherapy. This study presents the first systematic examination of PAT methodologies influencing antidepressant effects and provides preliminary insights for clinicians in designing future PAT protocols for depression.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106573"},"PeriodicalIF":7.9,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146054527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural mechanisms underlying orofacial prosocial behavior in rodents 啮齿动物口面亲社会行为的神经机制。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-23 DOI: 10.1016/j.neubiorev.2026.106572

Ji Wang , Mengbing Huang , Ziyun Ni , Zhi Zhang , Peng Cao

Social behavior is a highly complex process that requires appropriate response to social cues and is fundamental to the survival, reproduction, and well-being. Orofacial behavior, which refers to the dynamic movements and configurations of the mouth, lips, and jaw, is an evolutionarily conserved behavior present in both humans and animals. Rodents engage in a multitude of well-coordinated orofacial prosocial behaviors, such as vocalizing, sniffing, helping or rescuing, licking, and pup retrieval, which play critical roles in communication, emotion, and social affiliation. However, there still lack integrative frameworks that explain how these evolutionarily conserved motor actions are implemented at the neural circuit level and how they contribute to broader prosocial functions relevant to social behavior research and social deficits. In this review, we summarize recent advances in understanding the neural basis that trigger the expression of orofacial prosocial behavior in animal studies, particularly in rodents.

社会行为是一个高度复杂的过程，需要对社会暗示做出适当的反应，是生存、繁殖和幸福的基础。口面部行为是指嘴、嘴唇和下巴的动态运动和结构，是人类和动物都存在的一种进化保守行为。啮齿类动物参与了大量协调良好的口腔面部亲社会行为，如发声、嗅探、帮助或拯救、舔舐和幼仔找回，这些行为在交流、情感和社会关系中起着至关重要的作用。然而，目前仍然缺乏综合框架来解释这些进化上保守的运动动作是如何在神经回路水平上实现的，以及它们如何促进与社会行为研究和社会缺陷相关的更广泛的亲社会功能。在这篇综述中，我们总结了在动物研究中，特别是在啮齿动物中，对触发口面亲社会行为表达的神经基础的理解的最新进展。

引用次数: 0

Effectiveness of cognitive interventions in healthy aging: A systematic review and Bayesian meta-analysis 认知干预在健康老龄化中的有效性：一项系统综述和贝叶斯元分析。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-22 DOI: 10.1016/j.neubiorev.2026.106571

Sara Pegoraro , Laura Veronelli , Francesca Frisco , Elvira Brattico , Daniele Romano , Roberta Daini , Giorgia Tosi

The global increase of the aging population poses major public health challenges, particularly due to the rising prevalence of age-related diseases. Among these, dementia stands out as a condition with the most significant health, social, and economic impact. Primary prevention in healthy aging, thus far, represents the most effective strategy to address this issue, and cognitive interventions emerge as promising tools to enhance and preserve cognitive functions over time. This study aimed to provide a systematic review and meta-analysis of cognitive interventions in healthy older adults, assessing their effectiveness both on cognitive performance (i.e., global cognitive functioning and main cognitive domains), measured by neuropsychological tests, and psychological components (e.g., psychiatric symptoms, quality of life, reported cognitive complaints). The use of a multilevel Bayesian approach allowed us to enhance the reliability of our findings by accounting for data structure and variability across studies. A total of 51 studies were included in the systematic review, and 43 in the meta-analysis. The results indicated that, compared to control groups, cognitive interventions are more effective in improving overall cognition (0.26; 95 % CI [0.08, 0.44]). Evidence of effectiveness, albeit with smaller effect sizes, was also observed on specific cognitive domains. No effects emerged for psychological outcomes. Our findings underscore the relevance of cognitive interventions as an effective tool to promote cognitive health and prevent cognitive decline in the aging population. More research will be necessary to explore further the effectiveness of cognitive intervention on psychological components.

全球老龄化人口的增加对公共卫生构成了重大挑战，特别是由于与年龄有关的疾病的发病率不断上升。在这些疾病中，痴呆症是对健康、社会和经济影响最大的一种疾病。到目前为止，健康老龄化的初级预防是解决这一问题的最有效策略，认知干预是随着时间的推移增强和保持认知功能的有希望的工具。本研究旨在对健康老年人的认知干预进行系统回顾和荟萃分析，评估其在认知表现（即整体认知功能和主要认知领域）和心理成分（如精神症状、生活质量、报告的认知抱怨）方面的有效性。多层贝叶斯方法的使用使我们能够通过考虑数据结构和跨研究的可变性来提高我们发现的可靠性。系统综述共纳入51项研究，荟萃分析纳入43项研究。结果表明，与对照组相比，认知干预在改善整体认知方面更有效（0.26;95% CI[0.08, 0.44]）。尽管效果较小，但在特定的认知领域也观察到了有效性的证据。对心理结果没有影响。我们的研究结果强调了认知干预作为促进认知健康和预防老龄化人口认知能力下降的有效工具的相关性。需要更多的研究来进一步探索认知干预对心理成分的有效性。

{"title":"Effectiveness of cognitive interventions in healthy aging: A systematic review and Bayesian meta-analysis","authors":"Sara Pegoraro , Laura Veronelli , Francesca Frisco , Elvira Brattico , Daniele Romano , Roberta Daini , Giorgia Tosi","doi":"10.1016/j.neubiorev.2026.106571","DOIUrl":"10.1016/j.neubiorev.2026.106571","url":null,"abstract":"<div><div>The global increase of the aging population poses major public health challenges, particularly due to the rising prevalence of age-related diseases. Among these, dementia stands out as a condition with the most significant health, social, and economic impact. Primary prevention in healthy aging, thus far, represents the most effective strategy to address this issue, and cognitive interventions emerge as promising tools to enhance and preserve cognitive functions over time. This study aimed to provide a systematic review and meta-analysis of cognitive interventions in healthy older adults, assessing their effectiveness both on cognitive performance (i.e., global cognitive functioning and main cognitive domains), measured by neuropsychological tests, and psychological components (e.g., psychiatric symptoms, quality of life, reported cognitive complaints). The use of a multilevel Bayesian approach allowed us to enhance the reliability of our findings by accounting for data structure and variability across studies. A total of 51 studies were included in the systematic review, and 43 in the meta-analysis. The results indicated that, compared to control groups, cognitive interventions are more effective in improving overall cognition (0.26; 95 % CI [0.08, 0.44]). Evidence of effectiveness, albeit with smaller effect sizes, was also observed on specific cognitive domains. No effects emerged for psychological outcomes. Our findings underscore the relevance of cognitive interventions as an effective tool to promote cognitive health and prevent cognitive decline in the aging population. More research will be necessary to explore further the effectiveness of cognitive intervention on psychological components.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106571"},"PeriodicalIF":7.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review on the association between executive function and emotional regulation in autism, ADHD, and autism/ADHD 自闭症、ADHD及自闭症/ADHD患者执行功能与情绪调节关系的系统综述

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-22 DOI: 10.1016/j.neubiorev.2026.106570

Marta Pozo-Rodríguez , Sara Cruz , Sabela Conde-Pumpido-Zubizarreta , Angel Carracedo , María Tubío-Fungueiriño , Montse Fernández-Prieto

Executive function (EF) and emotion regulation (ER) have been proposed as transdiagnostic factors that contribute to the socio-emotional and behavioural difficulties observed in neurodevelopmental disorders, particularly autism and attention deficit/hyperactivity disorder (ADHD). Investigating potential differences in the association between EF and ER in autism, ADHD and autism/ADHD co-occurrence could be an important avenue to inform possible differential diagnosis. In this study, we present a systematic review examining the associations between EF and ER in autism, ADHD, and autism/ADHD. PubMed, Web of Science, PsycInfo, and Scopus datasets were searched for empirical articles, published between January 2013 and October 2024. Twenty-two articles were included. Of these, four analysed the relationship between EF and ER in autism, 16 in ADHD and two in autism/ADHD, demonstrating a clear focus on the study of these dimensions in ADHD over the past decade. Although age (i.e., children versus adults) and methodological (i.e., task-based versus report-based measures) differences may contribute to the variability of findings, the overall evidence suggests an association between EF difficulties and emotional dysregulation across conditions. Further research comparing autism, ADHD and autism/ADHD individuals is needed to draw clearer conclusions about how the association between EF and ER differs across these neurodevelopmental disorders, to inform more accurate diagnosis.

执行功能（EF）和情绪调节（ER）被认为是导致神经发育障碍，特别是自闭症和注意缺陷多动障碍（ADHD）中观察到的社会情绪和行为困难的跨诊断因素。研究EF和ER在自闭症、ADHD和自闭症/ADHD共发中的潜在差异可能是告知可能的鉴别诊断的重要途径。在这项研究中，我们对自闭症、ADHD和自闭症/ADHD中EF和ER之间的关系进行了系统的回顾。在PubMed、Web of Science、PsycInfo和Scopus数据集上搜索了2013年1月至2024年10月之间发表的实证文章。共纳入22篇文章。其中，4项研究分析了自闭症患者的EF和ER之间的关系，16项研究分析了ADHD， 2项研究分析了自闭症/ADHD，这表明在过去十年中，对ADHD这些维度的研究得到了明确的关注。尽管年龄（即儿童与成人）和方法（即基于任务的与基于报告的测量）的差异可能导致结果的差异，但总体证据表明，EF困难与各种情况下的情绪失调之间存在关联。需要进一步的研究来比较自闭症、多动症和自闭症/多动症个体，以得出更明确的结论，了解EF和ER在这些神经发育障碍之间的关系是如何不同的，从而为更准确的诊断提供信息。

{"title":"A systematic review on the association between executive function and emotional regulation in autism, ADHD, and autism/ADHD","authors":"Marta Pozo-Rodríguez , Sara Cruz , Sabela Conde-Pumpido-Zubizarreta , Angel Carracedo , María Tubío-Fungueiriño , Montse Fernández-Prieto","doi":"10.1016/j.neubiorev.2026.106570","DOIUrl":"10.1016/j.neubiorev.2026.106570","url":null,"abstract":"<div><div>Executive function (EF) and emotion regulation (ER) have been proposed as transdiagnostic factors that contribute to the socio-emotional and behavioural difficulties observed in neurodevelopmental disorders, particularly autism and attention deficit/hyperactivity disorder (ADHD). Investigating potential differences in the association between EF and ER in autism, ADHD and autism/ADHD co-occurrence could be an important avenue to inform possible differential diagnosis. In this study, we present a systematic review examining the associations between EF and ER in autism, ADHD, and autism/ADHD. PubMed, Web of Science, PsycInfo, and Scopus datasets were searched for empirical articles, published between January 2013 and October 2024. Twenty-two articles were included. Of these, four analysed the relationship between EF and ER in autism, 16 in ADHD and two in autism/ADHD, demonstrating a clear focus on the study of these dimensions in ADHD over the past decade. Although age (i.e., children versus adults) and methodological (i.e., task-based versus report-based measures) differences may contribute to the variability of findings, the overall evidence suggests an association between EF difficulties and emotional dysregulation across conditions. Further research comparing autism, ADHD and autism/ADHD individuals is needed to draw clearer conclusions about how the association between EF and ER differs across these neurodevelopmental disorders, to inform more accurate diagnosis.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106570"},"PeriodicalIF":7.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0