Neuroscience and Biobehavioral Reviews最新文献_第4页

A systematic review on the association between executive function and emotional regulation in autism, ADHD, and autism/ADHD 自闭症、ADHD及自闭症/ADHD患者执行功能与情绪调节关系的系统综述

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-22 DOI: 10.1016/j.neubiorev.2026.106570

Marta Pozo-Rodríguez , Sara Cruz , Sabela Conde-Pumpido-Zubizarreta , Angel Carracedo , María Tubío-Fungueiriño , Montse Fernández-Prieto

Executive function (EF) and emotion regulation (ER) have been proposed as transdiagnostic factors that contribute to the socio-emotional and behavioural difficulties observed in neurodevelopmental disorders, particularly autism and attention deficit/hyperactivity disorder (ADHD). Investigating potential differences in the association between EF and ER in autism, ADHD and autism/ADHD co-occurrence could be an important avenue to inform possible differential diagnosis. In this study, we present a systematic review examining the associations between EF and ER in autism, ADHD, and autism/ADHD. PubMed, Web of Science, PsycInfo, and Scopus datasets were searched for empirical articles, published between January 2013 and October 2024. Twenty-two articles were included. Of these, four analysed the relationship between EF and ER in autism, 16 in ADHD and two in autism/ADHD, demonstrating a clear focus on the study of these dimensions in ADHD over the past decade. Although age (i.e., children versus adults) and methodological (i.e., task-based versus report-based measures) differences may contribute to the variability of findings, the overall evidence suggests an association between EF difficulties and emotional dysregulation across conditions. Further research comparing autism, ADHD and autism/ADHD individuals is needed to draw clearer conclusions about how the association between EF and ER differs across these neurodevelopmental disorders, to inform more accurate diagnosis.

执行功能（EF）和情绪调节（ER）被认为是导致神经发育障碍，特别是自闭症和注意缺陷多动障碍（ADHD）中观察到的社会情绪和行为困难的跨诊断因素。研究EF和ER在自闭症、ADHD和自闭症/ADHD共发中的潜在差异可能是告知可能的鉴别诊断的重要途径。在这项研究中，我们对自闭症、ADHD和自闭症/ADHD中EF和ER之间的关系进行了系统的回顾。在PubMed、Web of Science、PsycInfo和Scopus数据集上搜索了2013年1月至2024年10月之间发表的实证文章。共纳入22篇文章。其中，4项研究分析了自闭症患者的EF和ER之间的关系，16项研究分析了ADHD， 2项研究分析了自闭症/ADHD，这表明在过去十年中，对ADHD这些维度的研究得到了明确的关注。尽管年龄（即儿童与成人）和方法（即基于任务的与基于报告的测量）的差异可能导致结果的差异，但总体证据表明，EF困难与各种情况下的情绪失调之间存在关联。需要进一步的研究来比较自闭症、多动症和自闭症/多动症个体，以得出更明确的结论，了解EF和ER在这些神经发育障碍之间的关系是如何不同的，从而为更准确的诊断提供信息。

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引用次数: 0

miRNA-206 in muscle and central nervous system crosstalk during exercise: A double-edged sword with therapeutic potential 运动中miRNA-206在相声肌和中枢神经系统病理生理中的作用：一把具有治疗潜力的双刃剑。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-20 DOI: 10.1016/j.neubiorev.2026.106569

Amir Mohammad Malvandi , Laura Gerosa , Paola Maroni , Maria Emanuela Orlando , Abbas Mohammadipour , Giovanni Lombardi

Physical activity triggers complex molecular responses in skeletal muscle, with increasing evidence showing systemic signaling roles for muscle-derived microRNAs (myomiRs). Among these, miR-206 has attracted attention for its dual function: promoting muscle regeneration but potentially harming the central nervous system (CNS). This review examines how miR-206 expression is regulated during exercise and its effects on muscle biology—such as fiber-type specification, mitochondrial changes, and neuromuscular junction (NMJ) repair. It also explores the paradoxical effects of high miR-206 levels in the CNS, where it targets brain-derived neurotrophic factor (BDNF), reducing neuroplasticity and increasing vulnerability to neuropsychiatric and neurodegenerative diseases. The review highlights disease-specific aspects, showing miR-206 as harmful in Alzheimer’s, stroke, and depression, but potentially protective in amyotrophic lateral sclerosis (ALS). We discuss its potential as a biomarker and therapeutic target, stressing tissue-specific regulation approaches. Overall, miR-206 plays a key role in muscle–brain communication, with important implications for exercise, aging, and CNS disorders.

体力活动触发骨骼肌中复杂的分子反应，越来越多的证据表明肌肉来源的microRNAs （myomir）具有系统信号作用。其中，miR-206因其双重功能引起了人们的关注：促进肌肉再生，但可能损害中枢神经系统（CNS）。本文综述了miR-206在运动过程中的表达调控及其对肌肉生物学的影响，如纤维类型规范、线粒体变化和神经肌肉连接（NMJ）修复。它还探讨了高水平miR-206在中枢神经系统中的矛盾效应，在中枢神经系统中，miR-206靶向脑源性神经营养因子（BDNF），降低神经可塑性，增加对神经精神和神经退行性疾病的易感性。该综述强调了疾病特异性方面，显示miR-206在阿尔茨海默病、中风和抑郁症中有害，但在肌萎缩侧索硬化症（ALS）中可能具有保护作用。我们讨论其作为生物标志物和治疗靶点的潜力，强调组织特异性调节方法。总之，miR-206在肌脑通讯中起关键作用，对运动、衰老和中枢神经系统疾病具有重要意义。

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引用次数: 0

The involvement of endogenous brain rhythms in speech processing 内源性脑节律在言语处理中的作用。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-20 DOI: 10.1016/j.neubiorev.2026.106568

Tanja Atanasova , Joachim Gross , Johanna M. Rimmele , Anne Keitel

Endogenous brain rhythms are at the core of oscillation-based neurobiological theories of speech. These brain rhythms have been proposed to play a crucial role in speech segmentation, attention allocation, and the temporal and spectral processes involved in speech perception. Despite the strong theoretical foundations of oscillatory models, direct empirical evidence for their involvement in speech processing remains limited, partly due to the challenge of distinguishing endogenous rhythms from responses to external stimuli. We review prominent oscillation-based theories (dynamic attending, active sensing, asymmetric sampling in time, and segmentation theories) and the supporting empirical evidence from electrophysiological and brain stimulation studies. Finally, we suggest potential directions for future research that could clarify the contributions of endogenous rhythms to speech processing.

内源性脑节律是基于振荡的言语神经生物学理论的核心。这些脑节律在语音分割、注意力分配以及语音感知的时间和频谱过程中起着至关重要的作用。尽管振荡模型具有强大的理论基础，但它们参与语音处理的直接经验证据仍然有限，部分原因是区分内源性节律与外部刺激反应的挑战。我们回顾了著名的基于振荡的理论（动态参与、主动感知、不对称采样和分割理论）以及来自电生理和脑刺激研究的支持经验证据。最后，我们提出了未来研究的潜在方向，以阐明内源性节律对语音处理的贡献。

引用次数: 0

Exploring neurodiversity through an intersectional lens 通过交叉透镜探索神经多样性。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-19 DOI: 10.1016/j.neubiorev.2026.106567

Sarah Laxhmi Chellappa

引用次数: 0

Oxytocin’s impact on the social brain: Individual differences and context shape a core amygdala-mediated mechanism 催产素对社会脑的影响：个体差异和背景形成核心杏仁核介导的机制。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-17 DOI: 10.1016/j.neubiorev.2026.106566

I.Lam Leong, Xinze Wang, Haiyan Wu

Introduction

Research on the effects of intranasal oxytocin (IN-OXT) on social behavior has often yielded contradictory results, likely due to variability in sample characteristics and research methodologies. To understand oxytocin’s influence on neurophysiology and the associated social behaviors, this review synthesizes findings from the past decade on oxytocin’s impact on brain physiology, mainly measured by functional magnetic resonance imaging (fMRI) Blood Oxygenation Level Dependent (BOLD) signals. This includes studies on resting-state connectivity, task-based functional connectivity during social cognition tasks.

Methods

Following the PRISMA guidelines, we reviewed 27 studies sourced from Embase, Medline, and APA PsycINFO. Key characteristics of each study were summarized, including sample size, subject demographics, oxytocin dosage and administration duration, BOLD signal processing and analytical methods, social behavior assessments, and the primary fMRI and behavioral outcomes related to oxytocin’s effects.

Results

During resting-state, IN-OXT predominantly modulates the amygdala, precuneus and insula, influencing the functional organization of large- scale networks such as the default mode network and the salience network. Task-based fMRI studies revealed that oxytocin exerted stress-regulatory and context- dependent neurobehavioral effects through amygdala-centered activity, with direction and magnitude varying according to individual traits, sex, and dosage.

Discussion

We further discussed factors that influence IN-OXT’s effects on social behaviours. Future research should integrate molecular and neuromodulatory techniques, recruit more diverse samples, and employ ecologically valid paradigms such as hyperscanning to capture real-world social interaction dynamics.

关于鼻内催产素（in - oxt）对社会行为影响的研究经常产生相互矛盾的结果，可能是由于样本特征和研究方法的差异。为了了解催产素对神经生理和相关社会行为的影响，本综述综合了近十年来关于催产素对脑生理影响的研究成果，主要是通过功能磁共振成像（fMRI）血氧水平依赖（BOLD）信号来测量的。这包括静息状态连通性、基于任务的功能连通性在社会认知任务中的研究。方法：遵循PRISMA指南，我们回顾了来自Embase、Medline和APA PsycINFO的27项研究。总结了每项研究的关键特征，包括样本量、受试者人口统计、催产素剂量和给药时间、BOLD信号处理和分析方法、社会行为评估以及与催产素作用相关的主要功能磁共振成像和行为结果。结果：在静息状态下，IN-OXT主要调控杏仁核、楔前叶和脑岛，影响默认模式网络和显著性网络等大型网络的功能组织。任务型fMRI研究显示，催产素通过以杏仁核为中心的活动发挥压力调节和环境依赖的神经行为作用，其方向和大小根据个体特征、性别和剂量而变化。讨论：我们进一步讨论了影响IN-OXT对社会行为影响的因素。未来的研究应该整合分子和神经调节技术，招募更多不同的样本，并采用生态有效的范式，如超扫描来捕捉现实世界的社会互动动态。

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引用次数: 0

Your brain on nature: A scoping review of the neuroscience of nature exposure 你的大脑在自然：自然暴露的神经科学的范围审查。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-15 DOI: 10.1016/j.neubiorev.2026.106565

Constanza Baquedano , Antonia Olguí , Luis Sebastian Contreras-Huerta , Fernando E. Rosas , Mar Estarellas

The relationship between natural environments and human cognition has gathered increasing attention across disciplines, including neuroscience, environmental psychology, and public health. An expanding body of empirical evidence supports the notion that exposure to nature consistently promotes psychological and physiological well-being. However, our understanding of the neural mechanisms underlying these benefits remains limited. This scoping review synthesizes experimental findings from neuroimaging studies that have examined the effects of natural stimuli on brain function and cognitive-affective processing. Across real-world settings, controlled laboratory environments, and virtual reality, convergent neuroimaging findings from EEG, fMRI, fNIRS, and structural MRI indicate that exposure to natural stimuli is reliably associated with (i) acute reductions in activity within stress-related and self-referential circuits, (ii) shifts toward alpha/theta-dominated and more integrated large-scale network states consistent with attentional restoration, and (iii) longer-term macrostructural and white-matter advantages linked to cognition. While acknowledging heterogeneity, potential confounding, and predominantly correlational designs, these results are starting to delineate candidate neural mechanisms and moderators, which future research should test in preregistered, longitudinal, and mechanistic trials. These results highlight the potential role of natural environments for promoting mental health, with implications for neuroscience and public policy aimed at cultivating human well-being.

自然环境与人类认知之间的关系越来越受到各个学科的关注，包括神经科学、环境心理学和公共卫生。越来越多的经验证据支持这样一种观点，即接触自然始终能促进心理和生理健康。然而，我们对这些益处背后的神经机制的理解仍然有限。这篇综述综合了神经影像学研究的实验结果，这些研究检查了自然刺激对大脑功能和认知情感处理的影响。在现实世界环境、受控实验室环境和虚拟现实中，脑电图、功能磁共振成像、近红外光谱和结构磁共振成像的神经成像结果表明，暴露于自然刺激与(i)压力相关回路和自我参照回路内活动的急性减少可靠相关，（ii）转向以α / θ为主导的、更综合的大规模网络状态，与注意力恢复一致。（三）与认知相关的长期宏观结构和白质优势。在承认异质性、潜在的混淆和主要的相关设计的同时，这些结果开始描绘候选的神经机制和调节因子，未来的研究应该在预注册、纵向和机制试验中进行测试。这些结果突出了自然环境在促进心理健康方面的潜在作用，对旨在促进人类福祉的神经科学和公共政策具有启示意义。

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引用次数: 0

Interoception and allostatic load after stroke: A scoping review 脑卒中后的内感受和适应负荷：范围综述。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-15 DOI: 10.1016/j.neubiorev.2026.106555

Paul M. Jenkinson , Gerardo Salvato , Michela Bassolino , Maddalena Beccherle , Greta Vianello , Aikaterini Fotopoulou , Gabriella Bottini , Valentina Moro

Physiological regulation is critical for survival. Interoception (the ability to sense internal body state) is a key mechanism by which allostasis (the proactive adjustment of physiological systems) is achieved to maintain physiological stability. Because of the crucial role of the central nervous system in these functions, studying the effects of brain damage can enhance knowledge of these processes. This scoping review synthesises empirical evidence on how stroke affects interoceptive functions and allostatic load (the long-term “cost” to the body of maintaining the internal milieu), and whether these disruptions relate to stroke outcomes, recovery, and specific neural substrates. We reviewed 39 studies examining interoceptive abilities or allostatic load in stroke patients. Only one study assessed allostatic load directly, highlighting a major gap in the literature. Results indicate that stroke frequently impairs interoception across multiple domains, including cardiac and respiratory awareness, affective touch, temperature perception, hunger, and fatigue. These impairments are often linked to poorer functional outcomes, including reduced recovery, cognitive dysfunction, and altered body awareness. Insular and somatosensory lesions were most commonly associated with interoceptive deficits, though lesion mapping was inconsistently reported. Findings from a single study suggest that allostatic load may exacerbate post-stroke cognitive decline and health disparities, particularly in high-risk populations. We conclude that stroke disrupts internal bodily regulation in ways that likely affect recovery trajectories, yet systematic research into the interoceptive and allostatic consequences of stroke is nascent. Future research should prioritise mechanistic studies, standardised assessments, and targeted interventions to address interoception-related physiological dysregulation in stroke rehabilitation.

生理调节对生存至关重要。内感受（感知身体内部状态的能力）是实现异稳态（生理系统的主动调节）以维持生理稳定的关键机制。由于中枢神经系统在这些功能中起着至关重要的作用，研究脑损伤的影响可以增强对这些过程的认识。这篇综述综合了中风如何影响内感受功能和适应负荷（维持体内环境的长期“成本”）的经验证据，以及这些破坏是否与中风结局、恢复和特定的神经基质有关。我们回顾了39项关于脑卒中患者内感受能力或适应负荷的研究。只有一项研究直接评估了适应负荷，这突出了文献中的一个主要空白。结果表明，中风经常损害多个领域的内感受，包括心脏和呼吸意识、情感触摸、温度感知、饥饿和疲劳。这些损伤通常与较差的功能结果有关，包括恢复能力降低、认知功能障碍和身体意识改变。岛和体感觉病变最常与内感受性缺陷相关，尽管病变定位报道不一致。一项研究结果表明，适应负荷可能加剧脑卒中后认知能力下降和健康差异，特别是在高危人群中。我们得出的结论是，中风以可能影响恢复轨迹的方式扰乱身体内部调节，但对中风的内感受性和适应性后果的系统研究尚不成熟。未来的研究应优先考虑机制研究、标准化评估和有针对性的干预措施，以解决卒中康复中与内感受相关的生理失调。协议注册：开放科学框架https://osf.io/qmd4b。

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引用次数: 0

Insights into the role of the mechanosensitive Piezo1 channel and signaling mechanisms in CNS functions and diseases 机械敏感的Piezo1通道和信号传导机制在中枢神经系统功能和疾病中的作用。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-14 DOI: 10.1016/j.neubiorev.2026.106562

Mo Zhang , Yingying Ge , Zuo Wang , Hui Li , Guilin Wang , Yue Zhang , Xia Wang , Huifang Hou , Li Meng , Linyu Wei , Dongli Meng , Lu Wang , Hai-Yan Sheng , Yaling Yin , Sharifah Alawieyah Syed Mortadza , Sebastien Roger , Jing Li , Feng Ren , Lin-Hua Jiang

The mechanosensitive Piezo1 channel is widely distributed in the central nervous system (CNS), expressed by neurons, astrocytes, oligodendrocytes, microglia, neural stem and progenitor cells, retinal ganglion and photoreceptor cells and, moreover, neurovascular and lymphatic endothelial cells, implicating an important role for the Piezo1 channel in the CNS physiology and disease. Indeed, recent studies have disclosed that the Piezo1 channel plays a vital part in mediating or modulating numerous CNS functions, ranging from brain development, synapse function, neurogenesis, axonal (re)generation, axonal pathfinding, astrocyte-neuron communication, axonal myelination, immune response, brain vasculature modelling to cerebrospinal fluid drainage. There is also increasing evidence to indicate critical engagement of the Piezo1 channel in the pathogenesis and progression of multiple debilitating CNS conditions, exemplified by spinal cord injury, stroke and related ischemia/reperfusion brain damage, neurodegenerative diseases, and age-related macular degeneration. Here, we provide a comprehensive overview of the current understanding and highlight the unanswered questions regarding the roles and mechanisms of the Piezo1 channel in CNS functions and diseases, presenting the Piezo1 channel as an attractive therapeutic target to intervene CNS damage and diseases.

机械敏感的Piezo1通道广泛分布于中枢神经系统（CNS），神经元、星形胶质细胞、少突胶质细胞、小胶质细胞、神经干和祖细胞、视网膜神经节和光感受器细胞以及神经血管和淋巴内皮细胞均有表达，提示Piezo1通道在中枢神经系统生理和疾病中具有重要作用。事实上，最近的研究表明，Piezo1通道在介导或调节许多中枢神经系统功能中起着至关重要的作用，包括大脑发育、突触功能、神经发生、轴突（再生）产生、轴突寻径、星形细胞-神经元通讯、轴突髓鞘形成、免疫反应、脑血管建模和脑脊液引流。也有越来越多的证据表明，Piezo1通道在多种衰弱性中枢神经系统疾病的发病和进展中起着关键作用，例如脊髓损伤、中风和相关的缺血/再灌注脑损伤、神经退行性疾病和年龄相关性黄斑变性。在这里，我们全面概述了目前的理解，并强调了关于Piezo1通道在中枢神经系统功能和疾病中的作用和机制的未解决的问题，提出了Piezo1通道作为干预中枢神经系统损伤和疾病的有吸引力的治疗靶点。

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引用次数: 0

Spatial memory tasks in aged animals: Overcoming methodological challenges 老年动物的空间记忆任务：克服方法上的挑战

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-10 DOI: 10.1016/j.neubiorev.2026.106553

Lisa Bevilacqua , Giovanni Lai , Belinda Giorgetti , Davide Perini , Serena Marcozzi , Giorgia Bigossi , Maria Elisa Giuliani , Marco Malavolta , Marta Balietti

Memory declines in healthy aging, although deficits are heterogeneous. Implicit, procedural, and semantic memory, for example, are relatively preserved, whereas spatial abilities are particularly vulnerable. This vulnerability may reflect changes in the mechanisms underlying spatial navigation. Older adults tend to show impairments in allocentric processing, which encodes object-to-object relationships and environmental features, while relying more on egocentric, route-based strategies. Rodent studies are essential for investigating these changes. However, standard behavioral paradigms developed for young or adult animals may yield misleading or non-translatable results if applied without adaptation to aged mice and rats. This review focuses on four spatial memory tasks: the Morris water maze, the Barnes maze, the object location, and the spontaneous location recognition. These tests primarily rely on allocentric strategies and are sensitive to age-related alterations in the hippocampal-entorhinal cortex, the neural substrate for forming allocentric cognitive maps. The review highlights age-related characteristics, such as reduced physical fitness, sensory decline, and hormonal alterations, that require specific adjustments to experimental protocols, and outlines methodological considerations for adapting procedures, selecting additional assessments, and applying scoring systems in an unbiased manner. An exploratory survey of the literature is also presented to assess how frequently such adaptations are reported. Overall, the synthesis underscores the importance of methodological refinement for improving the validity and translational relevance of aging research.

在健康的衰老过程中，记忆力会下降，尽管记忆力下降的情况各不相同。例如，内隐记忆、程序记忆和语义记忆相对保存，而空间记忆尤其脆弱。这种脆弱性可能反映了空间导航机制的变化。老年人倾向于表现出异心加工的缺陷，这种加工编码对象与对象之间的关系和环境特征，而更多地依赖于以自我为中心的、基于路线的策略。啮齿动物研究对于调查这些变化至关重要。然而，为年轻或成年动物开发的标准行为范式如果不适应老年小鼠和大鼠，可能会产生误导性或不可翻译的结果。本文综述了Morris水迷宫、Barnes迷宫、物体定位和自发位置识别四种空间记忆任务。这些测试主要依赖于异位中心策略，并且对海马-内嗅皮层（形成异位中心认知地图的神经基质）中与年龄相关的变化很敏感。这篇综述强调了与年龄相关的特征，如身体素质下降、感觉下降和激素改变，这些特征需要对实验方案进行具体调整，并概述了调整程序、选择额外评估和以公正的方式应用评分系统的方法学考虑。还提出了一项探索性文献调查，以评估这种适应的报道频率。总的来说，综合强调了改进方法对提高老龄化研究的有效性和翻译相关性的重要性。

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引用次数: 0

The role of astrocytic ephrins and Eph receptors in astrocyte function, synaptic plasticity, and memory formation 星形胶质细胞ephrin和Eph受体在星形胶质细胞功能、突触可塑性和记忆形成中的作用。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-09 DOI: 10.1016/j.neubiorev.2026.106552

Raphael Lamprecht

Astrocytes play essential roles in brain functions, including regulating neurotransmitter reuptake, modulating synaptic activity through gliotransmission and signaling molecules, supporting neuronal metabolism, and influencing neuronal morphology. Astrocytes can modulate specific neuronal circuits, respond to environmental changes, and exhibit computational capabilities. Through these processes, astrocytes contribute to neuronal plasticity and memory formation. Among the key regulators of astrocytic function are Eph receptors and their interacting ephrin proteins. Eph receptors and ephrins control critical astrocytic processes and directly influence neuronal functions, including transmission and morphology. These effects include regulating glutamate transmission by controlling synaptic glutamate levels and d-serine-dependent modulation of glutamate receptors, as well as shaping dendritic spine morphology and affecting the number of synapses. Through these mechanisms, astrocytic Eph receptors and ephrins modulate synaptic plasticity and are central regulators of long-term memory formation.

星形胶质细胞在脑功能中发挥重要作用，包括调节神经递质再摄取，通过胶质传递和信号分子调节突触活动，支持神经元代谢，影响神经元形态。星形胶质细胞可以调节特定的神经元回路，对环境变化作出反应，并表现出计算能力。通过这些过程，星形胶质细胞有助于神经元的可塑性和记忆的形成。星形胶质细胞功能的关键调节因子是Eph受体及其相互作用的ephrin蛋白。Eph受体和ephrin控制星形胶质细胞的关键过程，并直接影响神经元的功能，包括传递和形态。这些作用包括通过控制突触谷氨酸水平和谷氨酸受体的d-丝氨酸依赖性调节来调节谷氨酸传递，以及塑造树突棘形态和影响突触数量。通过这些机制，星形细胞Eph受体和ephrin调节突触可塑性，是长期记忆形成的主要调节因子。

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引用次数: 0