Neuroscience and Biobehavioral Reviews最新文献_第4页

The impact of socio-environmental factors on brain structure over the early life course of preterm-born individuals - A systematic review

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-12 DOI: 10.1016/j.neubiorev.2025.106061

Taylor Barda , Benita Schmitz-Koep , Aurore Menegaux , Peter Bartmann , Dieter Wolke , Christian Sorg , Dennis M Hedderich

Background

Approximately 11 % of births worldwide are preterm (<37 weeks). While research traditionally focuses on complications of prematurity and brain development, the role of socio-environmental factors has received less attention. Recent studies indicate these factors significantly influence neurocognitive outcomes and brain development, beyond prematurity alone. This review examines the impact of socio-environmental factors on brain structure and function in preterm-born individuals from birth to early adulthood.

Method

We conducted searches in PubMed, Embase, and Web of Science for studies up to August 28th, 2024, examining socio-environmental effects on brain structure or function in preterm-born individuals using magnetic resonance imaging. From 891 articles screened, 23 met the inclusion criteria.

Results

Socio-environmental factors, including socioeconomic status, prenatal conditions, hospital environment, and early life experiences, notably affect brain structures in preterm-born individuals. Key impacts were found in limbic and associative cortices (e.g., cingulate gyrus, parieto-temporal cortices), white matter tracts involved in executive functioning (e.g., superior longitudinal fasciculus, cingulum), and overall brain volume. Most studies focused on infancy, with 18 of 23 presenting data from the first year of life.

Conclusion

Socio-environmental factors are associated with changes in grey and white matter in the brain, especially in the limbic system and associative areas. These findings underscore the influence of early environments on preterm-born brain development, but long-term impacts remain unclear due to limited data beyond infancy.

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引用次数: 0

Causal relationship between B vitamins and neuropsychiatric disorders: A systematic review and meta-analysis

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-12 DOI: 10.1016/j.neubiorev.2025.106068

Mengfei Ye , Xiaopeng Yang , Junwei Yan , Yiying Yao , Hongran Lv , Zihan Yue , Xiuqin Lin , Chao Qian , Zheng Liu

Recently, there has been an increasing interest in how diet and nutrition influence both physical and mental health. Numerous studies have highlighted the potential role of B vitamins in neuropsychiatric disorders (NPDs), yet the exact causal relationship between these nutrients and NPDs remains unclear. In our Mendelian randomization (MR) meta-analysis, we examined the links between B vitamins (VB6, VB12, and folate) and NPDs, utilizing data from previous MR studies, the UK Biobank, and FinnGen databases. Our MR analysis revealed a complex, multifaceted association: VB6 appears to protect against Alzheimer's disease (AD) but may increase the risk for conditions such as major depressive disorder and post-traumatic stress disorder. VB12 seems protective against autism spectrum disorder (ASD) but may heighten the risk for bipolar disorder (BD). Folate has shown protective effects against AD and intellectual disability (ID). The meta-analysis suggests that B vitamins may protect against certain disorders like AD and Parkinson’s disease, but they might also be risk factors for anxiety and other psychiatric conditions. Further subgroup analysis indicates that VB6 protects against epilepsy and schizophrenia but increases the risk of mania; VB12 protects against ID and ASD but raises the risk of schizophrenia and BD; folate protects against schizophrenia, AD, and ID. These findings reveal the intricate influence of B vitamins on mental health, emphasizing that different B vitamins have distinct impacts on various NPDs. This complexity underscores the importance of personalized supplementation in developing future therapeutic approaches for NPDs.

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引用次数: 0

An item-level systematic review of the presentation of ADHD in females

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-12 DOI: 10.1016/j.neubiorev.2025.106064

Tamara Williams , Louise Horstmann , Laiba Kayani , Annabelle Xiao Hui Lim , Abigail Russell , Tamsin Ford , Ann John , Kapil Sayal , Anita Thapar , Kate Langley , Joanna Martin

Previous studies examining sex differences in attention deficit hyperactivity disorder (ADHD) have primarily examined total or subscale scores. This systematic review aimed to examine which symptoms contribute to the female presentation of ADHD at an item-level. Six research literature databases were searched for studies comparing ADHD symptoms and their impact at an item-level in females with ADHD compared with: 1) males with ADHD and 2) females without ADHD. Thirteen studies were included. In childhood, females were more likely to display the symptoms ‘fails to sustain attention in tasks’ and ‘often easily distracted’, whereas males were more likely to display the symptoms ‘often fidgets’, ‘difficulty remaining seated when required’, ‘runs/climbs in situations when inappropriate’, ‘always on the go’, ‘often noisy in playing’, ‘difficulty waiting turn’, ‘often blurts out answers’ and ‘often interrupts others’. In adulthood, females were more likely to endorse the symptoms ‘easily distracted’, ‘difficulty organising tasks’, ‘blurts out answers’ and ‘talks excessively’, as well as to report mind wandering and adverse home impacts. Females with ADHD differ in their symptom profile to males with ADHD, highlighting the need for future research to identify and characterise symptoms typical of female ADHD.

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引用次数: 0

Vertical and horizontal space-valence associations: A meta-analysis

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-12 DOI: 10.1016/j.neubiorev.2025.106054

Jan Pohl , Alex Miklashevsky

Previous research found associations between lower vs. upper space and negative vs. positive stimuli correspondingly (vertical Space-Valence Associations, SVAs) and between the left vs. right side and negative vs. positive stimuli correspondingly (horizontal SVAs). We conducted a comprehensive meta-analysis of SVAs for both dimensions in behavioral studies. We tested the robustness of SVAs and examined factors potentially modulating them: participants’ culture, handedness, gender, age, the exact valence domain under study, the experimental task, type of stimuli, publication year, and statistics used. Articles were extracted from Web of Science, PubMed, and ScienceDirect in February 2021. Overall, 91 articles with 199 experiments and 21,951 participants were included in the final analysis.

We found robust evidence of SVAs in vertical (r = .440, k = 111 experiments) and horizontal dimensions (r = .310; k = 88 experiments), with little evidence for literature biases. The distribution of effect sizes was highly heterogeneous, even after subgroup analyses, which indicates unidentified factors varying across studies. Experiments on vertical SVAs explicitly asking participants to evaluate valence showed larger effect sizes than experiments where valence remained task-irrelevant. There was a robust effect of handedness on horizontal SVAs: Participants associated positive stimuli with the side of their dominant hand. There was also some evidence of cultural influences on the horizontal SVAs.

Overall, our meta-analysis revealed a hierarchy of factors modulating activation of SVAs, which includes both situated and embodied factors. It is, therefore, essential to focus on specific concept categories and contexts rather than consider abstract concepts in general.

Public significance statement

This meta-analysis revealed medium effects of space-valence associations: Upper/right space is associated with positive and lower/right space with negative concepts. On the vertical dimension, this effect is modulated by valence being task-relevant, e.g., directly asking people about valence results in stronger associations. For the horizontal dimension, left-handers robustly showed a reversed effect (i.e., left is good); horizontal space-valence associations might be even stronger in non-Western countries.

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引用次数: 0

Inflammatory markers associated with electroconvulsive therapy response in patients with depression: A meta-analysis

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-10 DOI: 10.1016/j.neubiorev.2025.106060

Annelies Dellink , Gertjan Vanderhaegen , Violette Coppens , Karen M. Ryan , Declan M. McLoughlin , Jennifer Kruse , Eric van Exel , Linda van Diermen , Jean-Baptiste Belge , Tore Ivar Malmei Aarsland , Manuel Morrens

Electroconvulsive therapy (ECT) is an effective intervention for severe unipolar and bipolar depression, yet its drawbacks often lead to its underutilization. Accurate prediction of ECT outcomes is crucial for optimizing patient care and increasing remission rates. This study synthesized existing evidence on the relationship between baseline inflammatory markers and ECT outcomes. Additionally, we explored whether changes in these markers during ECT correlated with symptom improvement. A correlation meta-analysis was conducted according to the PRISMA statement, including a total of fourteen studies (n = 556 patients). The analyses revealed that higher baseline CRP and IL-6 levels were significantly associated with greater depressive symptom reduction post-ECT. Additionally, our findings suggested that increases in kynurenine metabolites and IL-8 during treatment correlated with improved depressive symptoms, offering insights into the mechanistic aspects of depression and ECT. In conclusion, peripheral inflammation in depression, as measured by CRP and IL-6, is associated with better ECT outcomes and may guide treatment stratification. Further research on a broader range of cytokines and kynurenine metabolites is needed to confirm these findings.

{"title":"Inflammatory markers associated with electroconvulsive therapy response in patients with depression: A meta-analysis","authors":"Annelies Dellink , Gertjan Vanderhaegen , Violette Coppens , Karen M. Ryan , Declan M. McLoughlin , Jennifer Kruse , Eric van Exel , Linda van Diermen , Jean-Baptiste Belge , Tore Ivar Malmei Aarsland , Manuel Morrens","doi":"10.1016/j.neubiorev.2025.106060","DOIUrl":"10.1016/j.neubiorev.2025.106060","url":null,"abstract":"<div><div>Electroconvulsive therapy (ECT) is an effective intervention for severe unipolar and bipolar depression, yet its drawbacks often lead to its underutilization. Accurate prediction of ECT outcomes is crucial for optimizing patient care and increasing remission rates. This study synthesized existing evidence on the relationship between baseline inflammatory markers and ECT outcomes. Additionally, we explored whether changes in these markers during ECT correlated with symptom improvement. A correlation meta-analysis was conducted according to the PRISMA statement, including a total of fourteen studies (n = 556 patients). The analyses revealed that higher baseline CRP and IL-6 levels were significantly associated with greater depressive symptom reduction post-ECT. Additionally, our findings suggested that increases in kynurenine metabolites and IL-8 during treatment correlated with improved depressive symptoms, offering insights into the mechanistic aspects of depression and ECT. In conclusion, peripheral inflammation in depression, as measured by CRP and IL-6, is associated with better ECT outcomes and may guide treatment stratification. Further research on a broader range of cytokines and kynurenine metabolites is needed to confirm these findings.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106060"},"PeriodicalIF":7.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unpacking the complexities of consciousness: Theories and reflections

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-08 DOI: 10.1016/j.neubiorev.2025.106053

Liad Mudrik , Melanie Boly , Stanislas Dehaene , Stephen M. Fleming , Victor Lamme , Anil Seth , Lucia Melloni

As the field of consciousness science matures, the research agenda has expanded from an initial focus on the neural correlates of consciousness, to developing and testing theories of consciousness. Several theories have been put forward, each aiming to elucidate the relationship between consciousness and brain function. However, there is an ongoing, intense debate regarding whether these theories examine the same phenomenon. And, despite ongoing research efforts, it seems like the field has so far failed to converge around any single theory, and instead exhibits significant polarization. To advance this discussion, proponents of five prominent theories of consciousness—Global Neuronal Workspace Theory (GNWT), Higher-Order Theories (HOT), Integrated Information Theory (IIT), Recurrent Processing Theory (RPT), and Predictive Processing (PP)—engaged in a public debate in 2022, as part of the annual meeting of the Association for the Scientific Study of Consciousness (ASSC). They were invited to clarify the explananda of their theories, articulate the core mechanisms underpinning the corresponding explanations, and outline their foundational premises. This was followed by an open discussion that delved into the testability of these theories, potential evidence that could refute them, and areas of consensus and disagreement. Most importantly, the debate demonstrated that at this stage, there is more controversy than agreement between the theories, pertaining to the most basic questions of what consciousness is, how to identify conscious states, and what is required from any theory of consciousness. Addressing these core questions is crucial for advancing the field towards a deeper understanding and comparison of competing theories.

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引用次数: 0

Developing zebrafish models of Notch-related CNS pathologies

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-08 DOI: 10.1016/j.neubiorev.2025.106059

Natalia Erofeeva , David S. Galstyan , Longen Yang , Tatiana Strekalova , Lee Wei Lim , Murilo S. de Abreu , Nikita I. Golushko , Adam Michael Stewart , Allan V. Kalueff

Notch signaling is an evolutionarily conserved cellular pathway that regulates various stem cell functions, including fate determination, differentiation, proliferation, and apoptosis. This crucial signaling mechanism also plays an important role in the brain, regulating neurogenesis, cell differentiation, and homeostasis, whereas disrupted Notch signaling is linked to various neurodegenerative diseases and brain cancers. Here, we review the central nervous system (CNS) pathologies associated with aberrant Notch signaling, and summarize the available experimental (animal) models used to study these pathologies, with a special focus on zebrafish (Danio rerio). As genetic, pharmacological, and behavioral models in zebrafish have significantly advanced our understanding of Notch-related CNS disorders, future research is expected to further link Notch signaling to brain disorders and, eventually, lead to their more specific and targeted therapeuties.

{"title":"Developing zebrafish models of Notch-related CNS pathologies","authors":"Natalia Erofeeva , David S. Galstyan , Longen Yang , Tatiana Strekalova , Lee Wei Lim , Murilo S. de Abreu , Nikita I. Golushko , Adam Michael Stewart , Allan V. Kalueff","doi":"10.1016/j.neubiorev.2025.106059","DOIUrl":"10.1016/j.neubiorev.2025.106059","url":null,"abstract":"<div><div>Notch signaling is an evolutionarily conserved cellular pathway that regulates various stem cell functions, including fate determination, differentiation, proliferation, and apoptosis. This crucial signaling mechanism also plays an important role in the brain, regulating neurogenesis, cell differentiation, and homeostasis, whereas disrupted Notch signaling is linked to various neurodegenerative diseases and brain cancers. Here, we review the central nervous system (CNS) pathologies associated with aberrant Notch signaling, and summarize the available experimental (animal) models used to study these pathologies, with a special focus on zebrafish (<em>Danio rerio</em>). As genetic, pharmacological, and behavioral models in zebrafish have significantly advanced our understanding of Notch-related CNS disorders, future research is expected to further link Notch signaling to brain disorders and, eventually, lead to their more specific and targeted therapeuties.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"170 ","pages":"Article 106059"},"PeriodicalIF":7.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpersonal synchronization: An overlooked factor in development, social cognition, and psychopathology

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-08 DOI: 10.1016/j.neubiorev.2025.106037

Jessica Fattal, Dan P. McAdams, Vijay A. Mittal

Intact social functioning relies on a combination of explicit and implicit behavioral, attentional, and interpersonal processes referred to as “social cognition”. Characterizing these interpersonal processes forms a critical underpinning to understanding and treating psychopathology, particularly in disorders where deficits in social functioning do not emerge as a secondary symptom but rather as an essential feature of the disorder. Two of such disorders are autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SZ). However, despite the substantial overlap in the features of social dysfunction between ASD and SZ, including social cognitive deficits in theory of mind, perspective-taking, and empathy, there is a limited understanding of the mechanisms underlying those shared deficits, and how to treat them. We suggest that disruptions of interpersonal functioning emerge over the course of development, and that interpersonal synchronization, a phenomenon in which behavioral and physiological cues align between interacting partners, forms a critical component of social cognition that underlies the disruption in social functioning in ASD and SZ. We present a conceptual review of typical and atypical development of social processes and highlight the role of interpersonal synchronization across the course of development. Then, we review the existing evidence suggesting impairments in both the intentional and spontaneous synchronization of interpersonal processes in ASD and SZ, as well as studies suggesting that interpersonal synchronization and clinical symptoms may be improved through body-oriented interventions within these disorders. Finally, we suggest potential mechanisms that may underpin typical and atypical development of interpersonal synchronization.

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引用次数: 0

The resurgence of synthetic cannabinoid receptor agonists as adulterants in the Era of Cannabis legalization: Lessons from prior epidemics and clinical implications

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-06 DOI: 10.1016/j.neubiorev.2025.106043

Austin T. Jones , Alaa Marwan Abu Taha , Grover P. Miller

Momentum towards legalization of medical and recreational cannabis drives a convergence between natural cannabinoids and their synthetic counterparts, creating new clinical challenges in a second wave of exposures. This review critically examines the emerging challenges posed by synthetic cannabinoid receptor agonists (SCRAs) and semi-synthetic cannabinoids, emphasizing their clinical implications. SCRAs are potent full agonist activity that have been identified as adulterants in several recreational substances, including cannabis and opioids. Adulteration often leads to unpredictable clinical outcomes and exacerbates the potential for drug interactions. Drawing parallels with other drug epidemics, this paper highlights the urgent need for clinical preparedness to address the nuanced presentations of cannabinoid toxicity, stressing the importance of patient history, physical examination, and judicious use of supportive laboratory tests. This review serves as a cautionary tale and call to action for researchers and policymakers. There is a clear need for robust quality control measures, enhanced public awareness campaigns, and development of evidence-based clinical guidelines to mitigate the health risks associated with intentional and unintentional use of synthetic cannabinoids.

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引用次数: 0

Temporal integration as an adaptive process in visual perception, attention, and working memory

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-06 DOI: 10.1016/j.neubiorev.2025.106041

Elkan G. Akyürek

I propose that temporal integration is ubiquitous in visual perception, because it serves an adaptive role. To support this idea, I draw together evidence from historically separated research fields that target different timescales. At one extreme, this concerns the detection and discrimination of successive stimuli within intervals of less than a quarter of a second. At an intermediate level, associated with attentional episodes, intervals between half a second up to a few seconds are considered. Finally, at the other extreme, this involves high-level, conceptual events across intervals of multiple seconds or even minutes. Across such varying intervals, the nature of temporal integration and the resultant perceptual events are clearly different. I nevertheless propose that temporal integration should be understood as a continuous process that serves a common adaptive goal: To maximize the amount of useful information, at minimal costs, tailored to the observer’s current needs and circumstances. Emerging from this viewpoint are several research directions that might be pursued on the topic of temporal integration, and on its consequences for perception and memory.

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引用次数: 0