Aside from typical motor symptoms, impulse control issues related to engaging in actions or decision-making can manifest in Parkinson’s disease (PD). The lack of direct comparisons between impulsive action and impulsive choice domains hinders a comprehensive understanding of impaired impulse control in this population. Therefore, the current review integrates findings across behavioural measures of impulsive action and choice in PD samples, both on and off dopaminergic medication. The qualitative review of studies revealed a distinction between the two impulsivity domains in the context of PD. While impulsive action impairments present in early, non-medicated PD and persist throughout the disease, impulsive choice deficits may only emerge after time on medication. Research on impulsive choice, especially in non-medicated PD, is limited, and the impact of medication status and disease progression on both domains remains inconclusive. We recommend that future studies integrate impulsive action and choice task types within the same sample and employ longitudinal designs to monitor how disease progression and corresponding medication changes affect impulse control over time.
{"title":"Impulse control in Parkinson’s disease: Distinct effects between action and choice","authors":"Aliya C.M. Warden , Craig McAllister , Marit F.L. Ruitenberg , Hayley J. MacDonald","doi":"10.1016/j.neubiorev.2025.106026","DOIUrl":"10.1016/j.neubiorev.2025.106026","url":null,"abstract":"<div><div>Aside from typical motor symptoms, impulse control issues related to engaging in actions or decision-making can manifest in Parkinson’s disease (PD). The lack of direct comparisons between impulsive action and impulsive choice domains hinders a comprehensive understanding of impaired impulse control in this population. Therefore, the current review integrates findings across behavioural measures of impulsive action and choice in PD samples, both on and off dopaminergic medication. The qualitative review of studies revealed a distinction between the two impulsivity domains in the context of PD. While impulsive action impairments present in early, non-medicated PD and persist throughout the disease, impulsive choice deficits may only emerge after time on medication. Research on impulsive choice, especially in non-medicated PD, is limited, and the impact of medication status and disease progression on both domains remains inconclusive. We recommend that future studies integrate impulsive action and choice task types within the same sample and employ longitudinal designs to monitor how disease progression and corresponding medication changes affect impulse control over time.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106026"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.neubiorev.2025.106034
Sami George Sabbah , Georg Northoff
Accurate and early diagnosis of Depression and Anxiety is met with the challenge of comorbid presentations and the neglect of the basic disturbances of self in current diagnostic criteria. Here, we review studies employing functional magnetic resonance imaging (fMRI) with self-based tasks in major depressive disorder (MDD) and anxiety disorders (AD) to determine the transdiagnostic and differential-diagnostic applicability of neural markers related to the self. This systematic review identified three main findings: (I) Large-scale brain-wide changes related to self-dysfunction overlap significantly between MDD and AD. (II) Regional changes are unspecific to tasks and stimuli confirming their specificity to the self as distinguished from other cognitive functions. (III) MDD affects regions related to emotional-cognitive processing like the anterior cingulate cortex, while AD involves prefrontal and insular regions associated with interoceptive and emotional-cognitive regulation. Our systematic review shows the utility of the self as a transdiagnostic marker that exhibits neural topographic similarities across the diagnostic boundaries of MDD and AD. More fine-grained regional differences between MDD and AD can be found within their underlying large scale neural similarities, allowing for their differential-diagnostic specification. In conclusion, we demonstrate the relevance of the self as both a transdiagnostic and differential diagnostic neural marker in MDD and AD.
{"title":"The self in depression and anxiety as a transdiagnostic and differential-diagnostic neural marker: A systematic review","authors":"Sami George Sabbah , Georg Northoff","doi":"10.1016/j.neubiorev.2025.106034","DOIUrl":"10.1016/j.neubiorev.2025.106034","url":null,"abstract":"<div><div>Accurate and early diagnosis of Depression and Anxiety is met with the challenge of comorbid presentations and the neglect of the basic disturbances of self in current diagnostic criteria. Here, we review studies employing functional magnetic resonance imaging (fMRI) with self-based tasks in major depressive disorder (MDD) and anxiety disorders (AD) to determine the transdiagnostic and differential-diagnostic applicability of neural markers related to the self. This systematic review identified three main findings: (I) Large-scale brain-wide changes related to self-dysfunction overlap significantly between MDD and AD. (II) Regional changes are unspecific to tasks and stimuli confirming their specificity to the self as distinguished from other cognitive functions. (III) MDD affects regions related to emotional-cognitive processing like the anterior cingulate cortex, while AD involves prefrontal and insular regions associated with interoceptive and emotional-cognitive regulation. Our systematic review shows the utility of the self as a transdiagnostic marker that exhibits neural topographic similarities across the diagnostic boundaries of MDD and AD. More fine-grained regional differences between MDD and AD can be found within their underlying large scale neural similarities, allowing for their differential-diagnostic specification. In conclusion, we demonstrate the relevance of the self as both a transdiagnostic and differential diagnostic neural marker in MDD and AD.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106034"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.neubiorev.2025.106030
Luca Steardo Jr. , Martina D’Angelo , Francesco Monaco , Valeria Di Stefano , Luca Steardo
Bipolar disorder (BD) is characterized by a complex constellation of emotional, cognitive, and psychomotor disturbances, each deeply intertwined with underlying dysfunctions in large-scale brain networks and neurotransmitter systems. This manuscript integrates recent advances in neuroimaging, neuromodulation, and pharmacological research to provide a comprehensive view of BD’s pathophysiology, emphasizing the role of network-specific dysfunctions and their clinical manifestations. We explore how dysregulation within the fronto-limbic network, particularly involving the prefrontal cortex (PFC) and amygdala, underpins the emotional instability that defines both manic and depressive episodes. Additionally, impairments in the central executive network (CEN) and default mode network (DMN) are linked to cognitive deficits, with hyperactivity in the DMN driving rumination and cognitive inflexibility, while CEN underactivity contributes to attentional lapses and impaired executive function. Psychomotor symptoms, which oscillate between hyperactivity in mania and retardation in depression, are closely associated with imbalances in neurotransmitter systems, particularly dopamine and serotonin, within the basal ganglia-thalamo-cortical motor pathway. Recent studies indicate that these psychomotor disturbances are further exacerbated by disruptions in network connectivity, leading to impairments in both motor control and emotional regulation. Emerging therapeutic strategies are discussed, with a focus on neuromodulation techniques such as transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS), which show promise in restoring balance within these critical networks. Furthermore, pharmacological interventions that modulate synaptic functioning and neuronal plasticity offer potential for addressing both the emotional and motor symptoms of BD. This manuscript underscores the need for an integrative treatment approach that simultaneously targets neural circuits and neurotransmitter systems to address the full spectrum of symptoms in BD. Drawing on recent advancements in neurobiological models and therapeutic frameworks, this proposal outlines a pathway for the development of precision-tailored interventions. These approaches are designed to optimize cognitive, emotional, and psychomotor outcomes, ultimately striving to elevate the quality of life for individuals living with bipolar disorder (BD), while remaining firmly grounded in the latest empirical evidence and theoretical insights.
{"title":"Decoding neural circuit dysregulation in bipolar disorder: Toward an advanced paradigm for multidimensional cognitive, emotional, and psychomotor treatment","authors":"Luca Steardo Jr. , Martina D’Angelo , Francesco Monaco , Valeria Di Stefano , Luca Steardo","doi":"10.1016/j.neubiorev.2025.106030","DOIUrl":"10.1016/j.neubiorev.2025.106030","url":null,"abstract":"<div><div>Bipolar disorder (BD) is characterized by a complex constellation of emotional, cognitive, and psychomotor disturbances, each deeply intertwined with underlying dysfunctions in large-scale brain networks and neurotransmitter systems. This manuscript integrates recent advances in neuroimaging, neuromodulation, and pharmacological research to provide a comprehensive view of BD’s pathophysiology, emphasizing the role of network-specific dysfunctions and their clinical manifestations. We explore how dysregulation within the fronto-limbic network, particularly involving the prefrontal cortex (PFC) and amygdala, underpins the emotional instability that defines both manic and depressive episodes. Additionally, impairments in the central executive network (CEN) and default mode network (DMN) are linked to cognitive deficits, with hyperactivity in the DMN driving rumination and cognitive inflexibility, while CEN underactivity contributes to attentional lapses and impaired executive function. Psychomotor symptoms, which oscillate between hyperactivity in mania and retardation in depression, are closely associated with imbalances in neurotransmitter systems, particularly dopamine and serotonin, within the basal ganglia-thalamo-cortical motor pathway. Recent studies indicate that these psychomotor disturbances are further exacerbated by disruptions in network connectivity, leading to impairments in both motor control and emotional regulation. Emerging therapeutic strategies are discussed, with a focus on neuromodulation techniques such as transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS), which show promise in restoring balance within these critical networks. Furthermore, pharmacological interventions that modulate synaptic functioning and neuronal plasticity offer potential for addressing both the emotional and motor symptoms of BD. This manuscript underscores the need for an integrative treatment approach that simultaneously targets neural circuits and neurotransmitter systems to address the full spectrum of symptoms in BD. Drawing on recent advancements in neurobiological models and therapeutic frameworks, this proposal outlines a pathway for the development of precision-tailored interventions. These approaches are designed to optimize cognitive, emotional, and psychomotor outcomes, ultimately striving to elevate the quality of life for individuals living with bipolar disorder (BD), while remaining firmly grounded in the latest empirical evidence and theoretical insights.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106030"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.neubiorev.2024.105985
Patrick Anselme
Incentive salience theory both explains the directional component of motivation (in terms of cue attraction or “wanting”) and its energetic component, as a function of the strength of cue attraction. This theory characterizes cue- and reward-triggered approach behavior. But it does not tell us how behavior can show enhanced vigor under reward uncertainty, when cues are inconsistent or resources hidden. Reinforcement theory is also ineffective in explaining enhanced vigor in case reward expectation is low or nil. This paper provides a neurobehavioral interpretation of effort in situations of adversity (which always include some uncertainty about outcomes) that is complementary to the attribution of incentive salience to environmental cues. It is argued that manageable environmental challenges activate an unconscious process of self-determination to achieve “wanted” actions. This unconscious process is referred to as incentive effort, which involves the hypothalamo-pituitary-adrenal (HPA) axis, noradrenaline, as well as striatal dopamine. Concretely, HPA-induced dopamine release would have the function to make effort—or effortful actions—“wanted” in a challenging context, in which the environmental cues are poorly predictive of reward—i.e., unattractive. Stress would only emerge in the presence of unmanageable challenges. It is hypothesized that incentive effort is the core psychological basis of will—and is, for this reason, termed “willing.”
{"title":"Unconscious will as a neurobehavioral mechanism against adversity","authors":"Patrick Anselme","doi":"10.1016/j.neubiorev.2024.105985","DOIUrl":"10.1016/j.neubiorev.2024.105985","url":null,"abstract":"<div><div>Incentive salience theory both explains the directional component of motivation (in terms of cue attraction or “wanting”) and its energetic component, as a function of the strength of cue attraction. This theory characterizes cue- and reward-triggered approach behavior. But it does not tell us how behavior can show enhanced vigor under reward uncertainty, when cues are inconsistent or resources hidden. Reinforcement theory is also ineffective in explaining enhanced vigor in case reward expectation is low or nil. This paper provides a neurobehavioral interpretation of effort in situations of adversity (which always include some uncertainty about outcomes) that is complementary to the attribution of incentive salience to environmental cues. It is argued that manageable environmental challenges activate an unconscious process of self-determination to achieve “wanted” actions. This unconscious process is referred to as incentive effort, which involves the hypothalamo-pituitary-adrenal (HPA) axis, noradrenaline, as well as striatal dopamine. Concretely, HPA-induced dopamine release would have the function to make effort—or effortful actions—“wanted” in a challenging context, in which the environmental cues are poorly predictive of reward—i.e., unattractive. Stress would only emerge in the presence of unmanageable challenges. It is hypothesized that incentive effort is the core psychological basis of will—and is, for this reason, termed “willing.”</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105985"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.neubiorev.2025.106018
Jesper Mulder , Mirte Boelens , Laura A. van der Velde , Michelle Brust , Jessica C. Kiefte-de Jong
Background
Interoception, the perception of the internal state of the body, offers an underrepresented and intriguing potential avenue for altering lifestyle-related behaviors. Interoception is intrinsically related to maintaining homeostasis and the flexible allostatic regulation of complex demands. Internal bodily states may also be influenced by lifestyle factors and related problems. This systematic review aimed to provide insight into the current state of evidence about the role of interoception in lifestyle factors.
Methods
Studies from three databases (PubMed, Embase, and Web of Science) were screened for eligibility based on two inclusion criteria: 1) at least one measure of interoception (e.g., interoceptive accuracy, attention, or awareness), and 2) at least one measure of a lifestyle factor (i.e., alcohol consumption, cognitive leisure and relaxation activities, eating behavior, exercise, sleep, or smoking). Risk of bias was assessed using an adjusted quality score checklist, consisting of five items related to study design, population size, exposure measurement, outcome measurement, and adjustment for confounders.
Results
The review included 73 studies. Out of the included studies, 51 measured interoceptive accuracy and 36 measured interoceptive attention. Six studies quantified interoceptive awareness. In terms of lifestyle factors, 26 studies on cognitive leisure and relaxation activities, 19 studies on eating behavior, 12 studies focused on alcohol consumption, 10 studies on exercise, five studies on smoking, and four studies on sleep were identified. Findings show positive relations between interoceptive domains and cognitive leisure and relaxation activities, eating behavior, and exercise. Conversely, the consumption of alcohol is negatively related to interoceptive domains. Studies in the smoking and sleep lifestyle factors were sparse and of varying methodological quality.
Discussion
The findings of this review show that interoceptive domains are associated with various lifestyle factors, but the quality of the evidence is limited. Future longitudinal studies with more objective measures of interoception are needed in order to better understand the interrelations between interoception and lifestyle factors.
{"title":"The role of interoception in lifestyle factors: A systematic review","authors":"Jesper Mulder , Mirte Boelens , Laura A. van der Velde , Michelle Brust , Jessica C. Kiefte-de Jong","doi":"10.1016/j.neubiorev.2025.106018","DOIUrl":"10.1016/j.neubiorev.2025.106018","url":null,"abstract":"<div><h3>Background</h3><div>Interoception, the perception of the internal state of the body, offers an underrepresented and intriguing potential avenue for altering lifestyle-related behaviors. Interoception is intrinsically related to maintaining homeostasis and the flexible allostatic regulation of complex demands. Internal bodily states may also be influenced by lifestyle factors and related problems. This systematic review aimed to provide insight into the current state of evidence about the role of interoception in lifestyle factors.</div></div><div><h3>Methods</h3><div>Studies from three databases (PubMed, Embase, and Web of Science) were screened for eligibility based on two inclusion criteria: 1) at least one measure of interoception (e.g., interoceptive accuracy, attention, or awareness), and 2) at least one measure of a lifestyle factor (i.e., alcohol consumption, cognitive leisure and relaxation activities, eating behavior, exercise, sleep, or smoking). Risk of bias was assessed using an adjusted quality score checklist, consisting of five items related to study design, population size, exposure measurement, outcome measurement, and adjustment for confounders.</div></div><div><h3>Results</h3><div>The review included 73 studies. Out of the included studies, 51 measured interoceptive accuracy and 36 measured interoceptive attention. Six studies quantified interoceptive awareness. In terms of lifestyle factors, 26 studies on cognitive leisure and relaxation activities, 19 studies on eating behavior, 12 studies focused on alcohol consumption, 10 studies on exercise, five studies on smoking, and four studies on sleep were identified. Findings show positive relations between interoceptive domains and cognitive leisure and relaxation activities, eating behavior, and exercise. Conversely, the consumption of alcohol is negatively related to interoceptive domains. Studies in the smoking and sleep lifestyle factors were sparse and of varying methodological quality.</div></div><div><h3>Discussion</h3><div>The findings of this review show that interoceptive domains are associated with various lifestyle factors, but the quality of the evidence is limited. Future longitudinal studies with more objective measures of interoception are needed in order to better understand the interrelations between interoception and lifestyle factors.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106018"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The rising prevalence of treatment-resistant neuropsychiatric disorders underscores the need for innovative and effective treatment strategies. The gut microbiota (GM) plays a pivotal role in the progression of these diseases, influencing the brain and mental health through the gut-brain axis (GBA). The vagus nerve plays a significant role in the GBA, making it a key area of focus for potential novel therapeutic interventions. Vagus nerve stimulation (VNS) was introduced and approved as a treatment for refractory forms of some neuropsychological disorders, such as depression and epilepsy. Considering its impact on several brain regions that play a vital part in mood, motivation, affection, and cognitive function, the VNS has shown significant therapeutic potential for treating a variety of neuropsychiatric disorders. Using VNS to target the bidirectional communication pathways linking the GM and the VN could present an exciting and novel approach to treating neuropsychological disorders. Imbalances in the GM, such as dysbiosis, can impair the communication pathways between the gut and the brain, contributing to the development of neuropsychological disorders. VNS shows potential for modulating these interconnected systems, helping to restore balance. Interestingly, the composition of the GM may also influence the effectiveness of VNS, as it has the potential to modify the brain's response to this therapeutic approach. This study provides a comprehensive analysis of a relatively unexplored but noteworthy interaction between VNS and GM in the treatment of neuropsychiatric disorders. In addition, we discussed the mechanisms, therapeutic potential, and clinical implications of VNS on the GBA across neuropsychiatric disorders.
{"title":"Vagus nerve stimulation and gut microbiota interactions: A novel therapeutic avenue for neuropsychiatric disorders","authors":"Navid Faraji , Bahareh Payami , Negar Ebadpour , Ali Gorji","doi":"10.1016/j.neubiorev.2024.105990","DOIUrl":"10.1016/j.neubiorev.2024.105990","url":null,"abstract":"<div><div>The rising prevalence of treatment-resistant neuropsychiatric disorders underscores the need for innovative and effective treatment strategies. The gut microbiota (GM) plays a pivotal role in the progression of these diseases, influencing the brain and mental health through the gut-brain axis (GBA). The vagus nerve plays a significant role in the GBA, making it a key area of focus for potential novel therapeutic interventions. Vagus nerve stimulation (VNS) was introduced and approved as a treatment for refractory forms of some neuropsychological disorders, such as depression and epilepsy. Considering its impact on several brain regions that play a vital part in mood, motivation, affection, and cognitive function, the VNS has shown significant therapeutic potential for treating a variety of neuropsychiatric disorders. Using VNS to target the bidirectional communication pathways linking the GM and the VN could present an exciting and novel approach to treating neuropsychological disorders. Imbalances in the GM, such as dysbiosis, can impair the communication pathways between the gut and the brain, contributing to the development of neuropsychological disorders. VNS shows potential for modulating these interconnected systems, helping to restore balance. Interestingly, the composition of the GM may also influence the effectiveness of VNS, as it has the potential to modify the brain's response to this therapeutic approach. This study provides a comprehensive analysis of a relatively unexplored but noteworthy interaction between VNS and GM in the treatment of neuropsychiatric disorders. In addition, we discussed the mechanisms, therapeutic potential, and clinical implications of VNS on the GBA across neuropsychiatric disorders.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105990"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.neubiorev.2024.105995
Eleanor Nuzum , Radvile Medeisyte , Roopal Desai , Anastasia Tsipa , Caroline Fearn , Aphrodite Eshetu , Georgina Charlesworth , Gavin R. Stewart , Sebastian J. Crutch , Céline El Baou , Suman Kurana , Emilie V. Brotherhood , Katie Flanagan , Alberto Salmoiraghi , Amy Kerti , Joshua Stott , Amber John
Aims
Recent research has highlighted a link between dementia and increased risk of suicidal ideation, suicide attempts and suicide deaths. Understanding the relative risk of suicide between subtypes of dementia is important for services to offer appropriate intervention.
Method
We searched five databases from inception to July 2023 for peer-reviewed publications reporting suicidal ideation, suicide attempt or death by suicide for at least two dementia subtypes. Meta-analyses compared suicidality between subtypes of dementia with Alzheimer’s Disease (AD).
Results
From 4983 studies identified, 12 met inclusion criteria. Pooling data, people with Vascular Dementia were significantly more likely to experience suicidal ideation (OR= 2.02 [95 % CI= 1.06;3.8]) and attempt suicide (OR=1.94 [95 % CI= 1.28;2.94]) than people with AD, but not die by suicide (OR= 1.05 [95 % CI= 0.69;1.59]). People with Dementia with Lewy Bodies were significantly more likely to report suicidal ideation (OR= 1.56 [95 % CI= 1.09;2.23]) than AD but not attempt suicide (OR= 1.12 [95 % CI= 0.83;1.50]). People with Frontotemporal Dementia were significantly more likely to attempt suicide (OR= 2.42 [95 % CI= 1.02;5.72]) than people with AD but not report suicidal ideation (OR= 1.67 [95 % CI= 0.34;8.33]). People with Mixed Dementia were significantly more likely to attempt suicide (OR= 2.83 [95 % CI= 1.52;5.27]) than people with AD but not report suicidal ideation (OR = 1.65 [95 % CI= 0.5;5.46]).
Conclusions
Further research is needed to understand what underlies the increased risks of suicidal ideation and suicide attempts for rarer subtypes.
{"title":"Dementia subtypes and suicidality: A systematic review and meta-analysis","authors":"Eleanor Nuzum , Radvile Medeisyte , Roopal Desai , Anastasia Tsipa , Caroline Fearn , Aphrodite Eshetu , Georgina Charlesworth , Gavin R. Stewart , Sebastian J. Crutch , Céline El Baou , Suman Kurana , Emilie V. Brotherhood , Katie Flanagan , Alberto Salmoiraghi , Amy Kerti , Joshua Stott , Amber John","doi":"10.1016/j.neubiorev.2024.105995","DOIUrl":"10.1016/j.neubiorev.2024.105995","url":null,"abstract":"<div><h3>Aims</h3><div>Recent research has highlighted a link between dementia and increased risk of suicidal ideation, suicide attempts and suicide deaths. Understanding the relative risk of suicide between subtypes of dementia is important for services to offer appropriate intervention.</div></div><div><h3>Method</h3><div>We searched five databases from inception to July 2023 for peer-reviewed publications reporting suicidal ideation, suicide attempt or death by suicide for at least two dementia subtypes. Meta-analyses compared suicidality between subtypes of dementia with Alzheimer’s Disease (AD).</div></div><div><h3>Results</h3><div>From 4983 studies identified, 12 met inclusion criteria. Pooling data, people with Vascular Dementia were significantly more likely to experience suicidal ideation (OR= 2.02 [95 % CI= 1.06;3.8]) and attempt suicide (OR=1.94 [95 % CI= 1.28;2.94]) than people with AD, but not die by suicide (OR= 1.05 [95 % CI= 0.69;1.59]). People with Dementia with Lewy Bodies were significantly more likely to report suicidal ideation (OR= 1.56 [95 % CI= 1.09;2.23]) than AD but not attempt suicide (OR= 1.12 [95 % CI= 0.83;1.50]). People with Frontotemporal Dementia were significantly more likely to attempt suicide (OR= 2.42 [95 % CI= 1.02;5.72]) than people with AD but not report suicidal ideation (OR= 1.67 [95 % CI= 0.34;8.33]). People with Mixed Dementia were significantly more likely to attempt suicide (OR= 2.83 [95 % CI= 1.52;5.27]) than people with AD but not report suicidal ideation (OR = 1.65 [95 % CI= 0.5;5.46]).</div></div><div><h3>Conclusions</h3><div>Further research is needed to understand what underlies the increased risks of suicidal ideation and suicide attempts for rarer subtypes.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105995"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predictive coding for social perception: Complex interactions across space and time","authors":"Kirsten Rittershofer , Quirin Gehmacher , Clare Press","doi":"10.1016/j.neubiorev.2024.105993","DOIUrl":"10.1016/j.neubiorev.2024.105993","url":null,"abstract":"","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 105993"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.neubiorev.2024.105988
Gustavo Deco , Yonatan Sanz Perl , Katarina Jerotic , Anira Escrichs , Morten L. Kringelbach
Turbulence is a universal principle for fast energy and information transfer. Moving beyond the turbulence of fluid dynamics, turbulence has recently been demonstrated in brain dynamics. Importantly, turbulence can be expressed as the rich variability across spacetime of the local levels of synchronisation of coupled brain signals. In fact, the optimal mixing properties of turbulence is what allows for efficient transfer of energy/information over space and time in the brain. This is especially important for survival given the need to overcome the inherent slowness in neural dynamics. Here, we review the research showing that the turbulence offers a convenient framework for describing brain dynamics and that the scale-free nature of turbulence, reflected in power-laws, provides the necessary mechanisms for time-critical information transfer in the brain. Whole-brain modelling of turbulence as coupled-oscillators has been shown to provide precise signatures of many different brain states. The levels of turbulence change in disease, and careful research of the vortex space could potentially help discover new avenues for a better understanding of this breakdown and offer better control of these highly non-linear, non-equilibrium states. Overall, the framework of the turbulent brain is a highly fertile, fast developing field with great potential.
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Pub Date : 2025-02-01DOI: 10.1016/j.neubiorev.2025.106002
Samara Helena da Silva , Matheus Ribeiro Felippin , Letícia de Oliveira Medeiros , Cecília Hedin-Pereira , Anaelli Aparecida Nogueira-Campos
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder mainly defined by impairments in communication and socialization. Although motor symptoms are not typically considered central to the disease, their high frequency and early onset have been recurrently reported in the literature. Therefore, this scoping review provides a broad description of these motor impairments across all ages, as well as a discussion of their relevance and relation to other clinical aspects of ASD. The scientific search was carried out in Scopus, Pubmed, Embase, and Web of Science databases. Nineteen studies were selected after applying the eligibility criteria. The studies analyzed 784 participants diagnosed with ASD compared to 540 controls. Motor function was assessed by means of varied kinds of scales and questionnaires. The main motor domains evaluated included features of fine and gross motor skills, manual dexterity, coordination/motor control/praxis, balance, running speed/agility, strength, gait, whole-body movements, aiming and catching (ball skills), and repetitive movements. Motor impairments are consistently observed in ASD from the first years of life, persisting into adulthood. It includes a significant deficit in performance of manual, posture, strength, and gait behavior/skills. The deficits described in ASD comprised impairments in fine and gross motor skills, lower balance, lower cadence, and greater variation of gait control, as well as weakness among other features that leads this population to move in an adaptive way affecting their interactions in real life.
自闭症谱系障碍（Autism Spectrum Disorder， ASD）是一种以沟通和社交障碍为主要特征的神经发育障碍。虽然运动症状通常不被认为是疾病的中心，但它们的高频率和早发性在文献中已经反复报道。因此，本综述对所有年龄段的这些运动障碍进行了广泛的描述，并讨论了它们与ASD其他临床方面的相关性和关系。科学检索在Scopus、Pubmed、Embase和Web of Science数据库中进行。在应用资格标准后选择了19项研究。研究分析了784名被诊断为ASD的参与者和540名对照组。采用各种量表和问卷对运动功能进行评估。评估的主要运动领域包括精细和大运动技能、手灵巧性、协调/运动控制/实践、平衡、跑步速度/敏捷性、力量、步态、全身运动、瞄准和接球（球技能）以及重复运动的特征。运动障碍在ASD患者中从出生的头几年就一直存在，一直持续到成年。它包括手部、姿势、力量和步态行为/技能方面的显著缺陷。ASD描述的缺陷包括精细和大运动技能的损伤，较低的平衡，较低的节奏，步态控制的较大变化，以及导致该人群以适应性方式移动的其他特征的弱点，影响他们在现实生活中的互动。
{"title":"A scoping review of the motor impairments in autism spectrum disorder","authors":"Samara Helena da Silva , Matheus Ribeiro Felippin , Letícia de Oliveira Medeiros , Cecília Hedin-Pereira , Anaelli Aparecida Nogueira-Campos","doi":"10.1016/j.neubiorev.2025.106002","DOIUrl":"10.1016/j.neubiorev.2025.106002","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder mainly defined by impairments in communication and socialization. Although motor symptoms are not typically considered central to the disease, their high frequency and early onset have been recurrently reported in the literature. Therefore, this scoping review provides a broad description of these motor impairments across all ages, as well as a discussion of their relevance and relation to other clinical aspects of ASD. The scientific search was carried out in Scopus, Pubmed, Embase, and Web of Science databases. Nineteen studies were selected after applying the eligibility criteria. The studies analyzed 784 participants diagnosed with ASD compared to 540 controls. Motor function was assessed by means of varied kinds of scales and questionnaires. The main motor domains evaluated included features of fine and gross motor skills, manual dexterity, coordination/motor control/praxis, balance, running speed/agility, strength, gait, whole-body movements, aiming and catching (ball skills), and repetitive movements. Motor impairments are consistently observed in ASD from the first years of life, persisting into adulthood. It includes a significant deficit in performance of manual, posture, strength, and gait behavior/skills. The deficits described in ASD comprised impairments in fine and gross motor skills, lower balance, lower cadence, and greater variation of gait control, as well as weakness among other features that leads this population to move in an adaptive way affecting their interactions in real life.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"169 ","pages":"Article 106002"},"PeriodicalIF":7.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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