Neuroscience and Biobehavioral Reviews最新文献_第5页

Your brain on nature: A scoping review of the neuroscience of nature exposure 你的大脑在自然：自然暴露的神经科学的范围审查。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-15 DOI: 10.1016/j.neubiorev.2026.106565

Constanza Baquedano , Antonia Olguí , Luis Sebastian Contreras-Huerta , Fernando E. Rosas , Mar Estarellas

The relationship between natural environments and human cognition has gathered increasing attention across disciplines, including neuroscience, environmental psychology, and public health. An expanding body of empirical evidence supports the notion that exposure to nature consistently promotes psychological and physiological well-being. However, our understanding of the neural mechanisms underlying these benefits remains limited. This scoping review synthesizes experimental findings from neuroimaging studies that have examined the effects of natural stimuli on brain function and cognitive-affective processing. Across real-world settings, controlled laboratory environments, and virtual reality, convergent neuroimaging findings from EEG, fMRI, fNIRS, and structural MRI indicate that exposure to natural stimuli is reliably associated with (i) acute reductions in activity within stress-related and self-referential circuits, (ii) shifts toward alpha/theta-dominated and more integrated large-scale network states consistent with attentional restoration, and (iii) longer-term macrostructural and white-matter advantages linked to cognition. While acknowledging heterogeneity, potential confounding, and predominantly correlational designs, these results are starting to delineate candidate neural mechanisms and moderators, which future research should test in preregistered, longitudinal, and mechanistic trials. These results highlight the potential role of natural environments for promoting mental health, with implications for neuroscience and public policy aimed at cultivating human well-being.

自然环境与人类认知之间的关系越来越受到各个学科的关注，包括神经科学、环境心理学和公共卫生。越来越多的经验证据支持这样一种观点，即接触自然始终能促进心理和生理健康。然而，我们对这些益处背后的神经机制的理解仍然有限。这篇综述综合了神经影像学研究的实验结果，这些研究检查了自然刺激对大脑功能和认知情感处理的影响。在现实世界环境、受控实验室环境和虚拟现实中，脑电图、功能磁共振成像、近红外光谱和结构磁共振成像的神经成像结果表明，暴露于自然刺激与(i)压力相关回路和自我参照回路内活动的急性减少可靠相关，（ii）转向以α / θ为主导的、更综合的大规模网络状态，与注意力恢复一致。（三）与认知相关的长期宏观结构和白质优势。在承认异质性、潜在的混淆和主要的相关设计的同时，这些结果开始描绘候选的神经机制和调节因子，未来的研究应该在预注册、纵向和机制试验中进行测试。这些结果突出了自然环境在促进心理健康方面的潜在作用，对旨在促进人类福祉的神经科学和公共政策具有启示意义。

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引用次数: 0

Interoception and allostatic load after stroke: A scoping review 脑卒中后的内感受和适应负荷：范围综述。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-15 DOI: 10.1016/j.neubiorev.2026.106555

Paul M. Jenkinson , Gerardo Salvato , Michela Bassolino , Maddalena Beccherle , Greta Vianello , Aikaterini Fotopoulou , Gabriella Bottini , Valentina Moro

Physiological regulation is critical for survival. Interoception (the ability to sense internal body state) is a key mechanism by which allostasis (the proactive adjustment of physiological systems) is achieved to maintain physiological stability. Because of the crucial role of the central nervous system in these functions, studying the effects of brain damage can enhance knowledge of these processes. This scoping review synthesises empirical evidence on how stroke affects interoceptive functions and allostatic load (the long-term “cost” to the body of maintaining the internal milieu), and whether these disruptions relate to stroke outcomes, recovery, and specific neural substrates. We reviewed 39 studies examining interoceptive abilities or allostatic load in stroke patients. Only one study assessed allostatic load directly, highlighting a major gap in the literature. Results indicate that stroke frequently impairs interoception across multiple domains, including cardiac and respiratory awareness, affective touch, temperature perception, hunger, and fatigue. These impairments are often linked to poorer functional outcomes, including reduced recovery, cognitive dysfunction, and altered body awareness. Insular and somatosensory lesions were most commonly associated with interoceptive deficits, though lesion mapping was inconsistently reported. Findings from a single study suggest that allostatic load may exacerbate post-stroke cognitive decline and health disparities, particularly in high-risk populations. We conclude that stroke disrupts internal bodily regulation in ways that likely affect recovery trajectories, yet systematic research into the interoceptive and allostatic consequences of stroke is nascent. Future research should prioritise mechanistic studies, standardised assessments, and targeted interventions to address interoception-related physiological dysregulation in stroke rehabilitation.

生理调节对生存至关重要。内感受（感知身体内部状态的能力）是实现异稳态（生理系统的主动调节）以维持生理稳定的关键机制。由于中枢神经系统在这些功能中起着至关重要的作用，研究脑损伤的影响可以增强对这些过程的认识。这篇综述综合了中风如何影响内感受功能和适应负荷（维持体内环境的长期“成本”）的经验证据，以及这些破坏是否与中风结局、恢复和特定的神经基质有关。我们回顾了39项关于脑卒中患者内感受能力或适应负荷的研究。只有一项研究直接评估了适应负荷，这突出了文献中的一个主要空白。结果表明，中风经常损害多个领域的内感受，包括心脏和呼吸意识、情感触摸、温度感知、饥饿和疲劳。这些损伤通常与较差的功能结果有关，包括恢复能力降低、认知功能障碍和身体意识改变。岛和体感觉病变最常与内感受性缺陷相关，尽管病变定位报道不一致。一项研究结果表明，适应负荷可能加剧脑卒中后认知能力下降和健康差异，特别是在高危人群中。我们得出的结论是，中风以可能影响恢复轨迹的方式扰乱身体内部调节，但对中风的内感受性和适应性后果的系统研究尚不成熟。未来的研究应优先考虑机制研究、标准化评估和有针对性的干预措施，以解决卒中康复中与内感受相关的生理失调。协议注册：开放科学框架https://osf.io/qmd4b。

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引用次数: 0

Insights into the role of the mechanosensitive Piezo1 channel and signaling mechanisms in CNS functions and diseases 机械敏感的Piezo1通道和信号传导机制在中枢神经系统功能和疾病中的作用。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-14 DOI: 10.1016/j.neubiorev.2026.106562

Mo Zhang , Yingying Ge , Zuo Wang , Hui Li , Guilin Wang , Yue Zhang , Xia Wang , Huifang Hou , Li Meng , Linyu Wei , Dongli Meng , Lu Wang , Hai-Yan Sheng , Yaling Yin , Sharifah Alawieyah Syed Mortadza , Sebastien Roger , Jing Li , Feng Ren , Lin-Hua Jiang

The mechanosensitive Piezo1 channel is widely distributed in the central nervous system (CNS), expressed by neurons, astrocytes, oligodendrocytes, microglia, neural stem and progenitor cells, retinal ganglion and photoreceptor cells and, moreover, neurovascular and lymphatic endothelial cells, implicating an important role for the Piezo1 channel in the CNS physiology and disease. Indeed, recent studies have disclosed that the Piezo1 channel plays a vital part in mediating or modulating numerous CNS functions, ranging from brain development, synapse function, neurogenesis, axonal (re)generation, axonal pathfinding, astrocyte-neuron communication, axonal myelination, immune response, brain vasculature modelling to cerebrospinal fluid drainage. There is also increasing evidence to indicate critical engagement of the Piezo1 channel in the pathogenesis and progression of multiple debilitating CNS conditions, exemplified by spinal cord injury, stroke and related ischemia/reperfusion brain damage, neurodegenerative diseases, and age-related macular degeneration. Here, we provide a comprehensive overview of the current understanding and highlight the unanswered questions regarding the roles and mechanisms of the Piezo1 channel in CNS functions and diseases, presenting the Piezo1 channel as an attractive therapeutic target to intervene CNS damage and diseases.

机械敏感的Piezo1通道广泛分布于中枢神经系统（CNS），神经元、星形胶质细胞、少突胶质细胞、小胶质细胞、神经干和祖细胞、视网膜神经节和光感受器细胞以及神经血管和淋巴内皮细胞均有表达，提示Piezo1通道在中枢神经系统生理和疾病中具有重要作用。事实上，最近的研究表明，Piezo1通道在介导或调节许多中枢神经系统功能中起着至关重要的作用，包括大脑发育、突触功能、神经发生、轴突（再生）产生、轴突寻径、星形细胞-神经元通讯、轴突髓鞘形成、免疫反应、脑血管建模和脑脊液引流。也有越来越多的证据表明，Piezo1通道在多种衰弱性中枢神经系统疾病的发病和进展中起着关键作用，例如脊髓损伤、中风和相关的缺血/再灌注脑损伤、神经退行性疾病和年龄相关性黄斑变性。在这里，我们全面概述了目前的理解，并强调了关于Piezo1通道在中枢神经系统功能和疾病中的作用和机制的未解决的问题，提出了Piezo1通道作为干预中枢神经系统损伤和疾病的有吸引力的治疗靶点。

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引用次数: 0

Spatial memory tasks in aged animals: Overcoming methodological challenges 老年动物的空间记忆任务：克服方法上的挑战

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-10 DOI: 10.1016/j.neubiorev.2026.106553

Lisa Bevilacqua , Giovanni Lai , Belinda Giorgetti , Davide Perini , Serena Marcozzi , Giorgia Bigossi , Maria Elisa Giuliani , Marco Malavolta , Marta Balietti

Memory declines in healthy aging, although deficits are heterogeneous. Implicit, procedural, and semantic memory, for example, are relatively preserved, whereas spatial abilities are particularly vulnerable. This vulnerability may reflect changes in the mechanisms underlying spatial navigation. Older adults tend to show impairments in allocentric processing, which encodes object-to-object relationships and environmental features, while relying more on egocentric, route-based strategies. Rodent studies are essential for investigating these changes. However, standard behavioral paradigms developed for young or adult animals may yield misleading or non-translatable results if applied without adaptation to aged mice and rats. This review focuses on four spatial memory tasks: the Morris water maze, the Barnes maze, the object location, and the spontaneous location recognition. These tests primarily rely on allocentric strategies and are sensitive to age-related alterations in the hippocampal-entorhinal cortex, the neural substrate for forming allocentric cognitive maps. The review highlights age-related characteristics, such as reduced physical fitness, sensory decline, and hormonal alterations, that require specific adjustments to experimental protocols, and outlines methodological considerations for adapting procedures, selecting additional assessments, and applying scoring systems in an unbiased manner. An exploratory survey of the literature is also presented to assess how frequently such adaptations are reported. Overall, the synthesis underscores the importance of methodological refinement for improving the validity and translational relevance of aging research.

在健康的衰老过程中，记忆力会下降，尽管记忆力下降的情况各不相同。例如，内隐记忆、程序记忆和语义记忆相对保存，而空间记忆尤其脆弱。这种脆弱性可能反映了空间导航机制的变化。老年人倾向于表现出异心加工的缺陷，这种加工编码对象与对象之间的关系和环境特征，而更多地依赖于以自我为中心的、基于路线的策略。啮齿动物研究对于调查这些变化至关重要。然而，为年轻或成年动物开发的标准行为范式如果不适应老年小鼠和大鼠，可能会产生误导性或不可翻译的结果。本文综述了Morris水迷宫、Barnes迷宫、物体定位和自发位置识别四种空间记忆任务。这些测试主要依赖于异位中心策略，并且对海马-内嗅皮层（形成异位中心认知地图的神经基质）中与年龄相关的变化很敏感。这篇综述强调了与年龄相关的特征，如身体素质下降、感觉下降和激素改变，这些特征需要对实验方案进行具体调整，并概述了调整程序、选择额外评估和以公正的方式应用评分系统的方法学考虑。还提出了一项探索性文献调查，以评估这种适应的报道频率。总的来说，综合强调了改进方法对提高老龄化研究的有效性和翻译相关性的重要性。

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引用次数: 0

The role of astrocytic ephrins and Eph receptors in astrocyte function, synaptic plasticity, and memory formation 星形胶质细胞ephrin和Eph受体在星形胶质细胞功能、突触可塑性和记忆形成中的作用。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-09 DOI: 10.1016/j.neubiorev.2026.106552

Raphael Lamprecht

Astrocytes play essential roles in brain functions, including regulating neurotransmitter reuptake, modulating synaptic activity through gliotransmission and signaling molecules, supporting neuronal metabolism, and influencing neuronal morphology. Astrocytes can modulate specific neuronal circuits, respond to environmental changes, and exhibit computational capabilities. Through these processes, astrocytes contribute to neuronal plasticity and memory formation. Among the key regulators of astrocytic function are Eph receptors and their interacting ephrin proteins. Eph receptors and ephrins control critical astrocytic processes and directly influence neuronal functions, including transmission and morphology. These effects include regulating glutamate transmission by controlling synaptic glutamate levels and d-serine-dependent modulation of glutamate receptors, as well as shaping dendritic spine morphology and affecting the number of synapses. Through these mechanisms, astrocytic Eph receptors and ephrins modulate synaptic plasticity and are central regulators of long-term memory formation.

星形胶质细胞在脑功能中发挥重要作用，包括调节神经递质再摄取，通过胶质传递和信号分子调节突触活动，支持神经元代谢，影响神经元形态。星形胶质细胞可以调节特定的神经元回路，对环境变化作出反应，并表现出计算能力。通过这些过程，星形胶质细胞有助于神经元的可塑性和记忆的形成。星形胶质细胞功能的关键调节因子是Eph受体及其相互作用的ephrin蛋白。Eph受体和ephrin控制星形胶质细胞的关键过程，并直接影响神经元的功能，包括传递和形态。这些作用包括通过控制突触谷氨酸水平和谷氨酸受体的d-丝氨酸依赖性调节来调节谷氨酸传递，以及塑造树突棘形态和影响突触数量。通过这些机制，星形细胞Eph受体和ephrin调节突触可塑性，是长期记忆形成的主要调节因子。

{"title":"The role of astrocytic ephrins and Eph receptors in astrocyte function, synaptic plasticity, and memory formation","authors":"Raphael Lamprecht","doi":"10.1016/j.neubiorev.2026.106552","DOIUrl":"10.1016/j.neubiorev.2026.106552","url":null,"abstract":"<div><div>Astrocytes play essential roles in brain functions, including regulating neurotransmitter reuptake, modulating synaptic activity through gliotransmission and signaling molecules, supporting neuronal metabolism, and influencing neuronal morphology. Astrocytes can modulate specific neuronal circuits, respond to environmental changes, and exhibit computational capabilities. Through these processes, astrocytes contribute to neuronal plasticity and memory formation. Among the key regulators of astrocytic function are Eph receptors and their interacting ephrin proteins. Eph receptors and ephrins control critical astrocytic processes and directly influence neuronal functions, including transmission and morphology. These effects include regulating glutamate transmission by controlling synaptic glutamate levels and <span>d</span>-serine-dependent modulation of glutamate receptors, as well as shaping dendritic spine morphology and affecting the number of synapses. Through these mechanisms, astrocytic Eph receptors and ephrins modulate synaptic plasticity and are central regulators of long-term memory formation.</div></div>","PeriodicalId":56105,"journal":{"name":"Neuroscience and Biobehavioral Reviews","volume":"183 ","pages":"Article 106552"},"PeriodicalIF":7.9,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired theory of mind in Parkinson’s disease: A systematic review of etiological debates 帕金森病的心智理论受损：对病因学争论的系统回顾

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-08 DOI: 10.1016/j.neubiorev.2026.106551

Jiong Liu , Patrice Fort , Lili Chen , Jian-Sheng Lin

Impairment of theory of mind (ToM)—the ability to attribute mental states to others—has been identified as a non-motor feature of Parkinson’s disease (PD), potentially undermining social functioning and quality of life. A central controversy concerns whether ToM deficits arise directly from PD neuropathology or are secondary to general cognitive impairment, with growing evidence pointing to the latter. This systematic review examined 14 studies employing designs that allow stronger causal inference—including regression, between-group, and experimental paradigms—to assess the dependence or independence of ToM deficits in PD relative to cognitive impairment. Overall, ToM performance showed a robust dependence on cognitive abilities across studies: patients with cognitive impairment consistently performed worse on ToM tasks than cognitively preserved patients, while results comparing preserved patients to healthy controls were mixed. Moreover, ToM performance improved in PD patients following general cognitive training or when tasks minimized executive function demands, though the validity of such modified tasks is debated. These findings suggest that impaired ToM performance in PD largely reflects general cognitive dysfunction rather than a primary social-cognitive deficit. However, whether an intact intrinsic capacity for mental state inference persists in PD remains unresolved. Further high-quality studies are needed to clarify this relationship and to inform targeted interventions as well as theoretical insights into ToM itself.

心理理论（ToM）的损伤——将精神状态归因于他人的能力——已被确定为帕金森病（PD）的非运动特征，潜在地破坏社会功能和生活质量。一个核心的争论是关于汤姆神经功能障碍是直接由PD神经病理引起还是继发于一般认知障碍，越来越多的证据指向后者。本系统综述检查了14项研究，这些研究采用了更强的因果推理设计，包括回归、组间和实验范式，以评估PD中ToM缺陷与认知障碍的依赖性或独立性。总体而言，在所有研究中，认知障碍患者的表现对认知能力有很强的依赖性：认知障碍患者在认知障碍任务中的表现始终比认知障碍患者差，而将认知障碍患者与健康对照组进行比较的结果则好坏参半。此外，PD患者在接受一般认知训练或当任务最小化执行功能需求时，ToM表现得到改善，尽管这种修改后的任务的有效性存在争议。这些发现表明，PD患者的ToM表现受损在很大程度上反映了一般的认知功能障碍，而不是主要的社会认知缺陷。然而，PD是否具有完整的内在心理状态推断能力仍未得到解决。需要进一步的高质量研究来澄清这种关系，并为有针对性的干预措施以及对ToM本身的理论见解提供信息。

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引用次数: 0

A systematic review of pharmacological effects on human aversive memory 对人类厌恶记忆药理作用的系统综述。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-07 DOI: 10.1016/j.neubiorev.2026.106548

Yanfang Xia , Boris B. Quednow , Dominik R. Bach

A large body of work has investigated the effect of various pharmacological compounds on aversive memory formation, retrieval, and modification in humans. A broad overview across signalling pathways and memory models is currently lacking. Here, we systematically review publications that tested the impact of acute pharmacological interventions on aversive memory in healthy humans, following PRISMA-2020. We identified 215 candidate compounds from 17 systems and searched PubMed, Web of Science and Scopus, until 14 June 2024. We identified 100 publications with 36 compounds targeting 13 systems. Three compounds were used by the majority of studies: hydrocortisone (n = 25), propranolol (n = 19), and D-cycloserine (n = 8), while many of the remaining 33 compounds were investigated in single studies only. We summarise the effect of each investigated compound across memory models, according to the targeted memory stage. Solid evidence emerges for an impact of propranolol on reconsolidation, and weak evidence for an impact of propranolol, 3,4-methylenedioxymethamphetamine (MDMA), benzodiazepines, yohimbine, reboxetine, and D-cycloserine on aversive memory encoding/consolidation, and valproic acid on extinction encoding/consolidation. Furthermore, 15 compounds showed significant effects in individual studies with no published replication attempts to date. We discuss potential research directions and suggest steps for greater comparability of findings between compounds, memory models, and laboratories.

大量的工作已经研究了各种药理学化合物对人类厌恶记忆形成、恢复和修改的影响。目前缺乏对信号通路和记忆模型的广泛概述。在此，我们系统地回顾了在PRISMA-2020之后测试急性药物干预对健康人厌恶记忆影响的出版物。截至2024年6月14日，我们从17个体系中鉴定出215个候选化合物，并检索了Pubmed， Web of Science和Scopus。我们鉴定了100份出版物，其中36种化合物靶向13个系统。大多数研究使用了三种化合物：氢化可的松（n=25），普萘洛尔（n=19）和d -环丝氨酸（n=8），而其余33种化合物中的许多仅在单一研究中进行了研究。根据目标记忆阶段，我们总结了每个研究化合物在记忆模型中的作用。有确凿的证据表明心得安对再巩固有影响，而心得安、3,4-亚甲基二氧基甲基苯丙胺（MDMA）、苯二氮卓类药物、育亨宾、瑞波西汀和d -环丝氨酸对厌恶记忆编码/巩固和丙戊酸对消退编码/巩固有影响的证据较弱。此外，15种化合物在个别研究中显示出显著的效果，迄今为止没有发表的复制尝试。我们讨论了潜在的研究方向，并提出了提高化合物、记忆模型和实验室之间研究结果可比性的步骤。

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引用次数: 0

Efficacy of non-invasive brain stimulation in treatment-resistant schizophrenia: A systematic review and network meta-analysis 非侵入性脑刺激治疗难治性精神分裂症的疗效：系统回顾和网络荟萃分析

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-07 DOI: 10.1016/j.neubiorev.2026.106549

Harry Kam Hung Tsui , Vincent Law , Charmaine Tsz Wing Wong , Wing Tse , Hiu Ching Lim , Ciren Zhuoma , Kelvin O. Lim , Georg S. Kranz , Sherry Kit Wa Chan

About one-third of patients with schizophrenia are classified as treatment-resistant schizophrenia (TRS) experiencing persistent symptoms despite adequate antipsychotic trials. Non-invasive brain stimulation (NIBS) emerged as a promising alternative treatment for TRS, yet its comparative efficacy remains unclear. We conducted a systematic review and network meta-analysis (NMA) to investigate the efficacy of NIBS for TRS patients (PROSPERO: CRD42023442563). Randomized trials comparing NIBS with sham or other active interventions in TRS patients were included. NMA with frequentist random-effects models was conducted, with subgroup and sensitivity analyses. Primary outcomes were changes in positive symptoms, auditory hallucinations, negative symptoms, and overall symptoms, calculated using standardized mean differences (SMD). From 1586 studies, 55 studies with 33 NIBS modalities and 1981 TRS patients were included. Low-frequency repetitive transcranial magnetic stimulation over the left temporoparietal junction (LF-rTMS-LTPJ) and neuronavigated continuous theta burst stimulation targeting the left temporoparietal cortex (cTBS-LTPC) significantly improved positive symptoms and auditory hallucinations compared to sham. LF-rTMS-LTPJ showed robust effects on auditory hallucinations (SMD = −0.784, 95 % CI = −1.202 to −0.366). Multiple NIBS modalities significantly improved negative and overall symptoms, with neuronavigated cTBS-LTPC and neuronavigated intermittent theta burst stimulation targeting the left dorsolateral prefrontal cortex showing superior efficacy than others. All modalities were acceptable. No publication bias and inconsistency were detected, whereas studies on positive symptoms and auditory hallucinations were high in heterogeneity with low confidence in evidence. LF-rTMS-LTPJ demonstrates consistent efficacy for auditory hallucinations in TRS and can be recommended for clinical practice. Other NIBS interventions, particularly neuronavigated cTBS-LTPC, show promise but require further validation through large-scale trials with personalized approaches to optimize treatment outcomes.

大约三分之一的精神分裂症患者被归类为难治性精神分裂症（TRS），尽管进行了充分的抗精神病药物试验，但症状仍持续存在。非侵入性脑刺激（NIBS）成为TRS的一种有希望的替代治疗方法，但其相对疗效尚不清楚。我们进行了系统评价和网络荟萃分析（NMA）来研究NIBS对TRS患者的疗效（PROSPERO: CRD42023442563）。纳入了比较NIBS与假干预或其他积极干预治疗TRS患者的随机试验。采用频率随机效应模型进行NMA，并进行亚组分析和敏感性分析。主要结局是阳性症状、幻听、阴性症状和总体症状的变化，使用标准化平均差异（SMD）计算。从1586项研究中，纳入了55项研究，33项NIBS模式和1981例TRS患者。与假手术相比，低频重复经颅磁刺激（LF-rTMS-LTPJ）和神经导航连续θ波脉冲刺激（cTBS-LTPC）可显著改善阳性症状和幻听。LF-rTMS-LTPJ对幻听效果显著（SMD = - 0.784, 95 % CI = - 1.202 ~ - 0.366）。多种NIBS治疗方式显著改善阴性症状和整体症状，神经导航cTBS-LTPC和针对左背外侧前额叶皮层的神经导航间歇性θ波爆发刺激效果优于其他治疗方式。所有方式都是可以接受的。未发现发表偏倚和不一致，而对阳性症状和幻听的研究异质性高，证据置信度低。LF-rTMS-LTPJ对TRS中的幻听有一致的疗效，可推荐用于临床实践。其他NIBS干预措施，特别是神经导航cTBS-LTPC，显示出希望，但需要通过大规模试验和个性化方法进一步验证，以优化治疗结果。

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引用次数: 0

Lonely minds in lonely bodies: Loneliness as insufficient psychological and neurophysiological self-other overlap 孤独的心灵在孤独的身体：孤独是心理上和神经生理上的自我-他者重叠不足

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-07 DOI: 10.1016/j.neubiorev.2026.106550

Ruofan Ma , Beier Yao

Loneliness affects the health and wellbeing of a substantial proportion of the global population, posing a major public health concern. Loneliness, despite being an emotional state experienced within oneself, represents a sense of isolation from other individuals beyond the self. Most contemporary psychological research on emotion, especially in adults, takes an individualistic approach and is limited in accounting for “other” minds when studying the mind of a “self.” On the other hand, studies of the neurophysiology of loneliness have mostly focused on presenting the biological correlates of loneliness, not accounting for the role of loneliness in representing pre-existing or anticipated biological needs. In this article, we review interdisciplinary research on self-other representation at levels of the mind, body, and brain. We propose neurophysiological mechanisms that support self-other overlap, guided by theories of allostatic-interoceptive self-regulation and situated in a predictive processing framework. These findings suggest that self-other representation in the body and brain may form a basis for social connection, and loneliness may be associated with insufficient self-other overlap. We discuss clinical implications of this model, especially in borderline personality disorder, and end with future theoretical and methodological considerations in advancing loneliness research.

孤独影响着全球很大一部分人口的健康和福祉，构成了一个重大的公共卫生问题。孤独，尽管是一种内心的情感状态，但它代表了一种超越自我的与他人的孤立感。大多数关于情感的当代心理学研究，尤其是对成年人的研究，都采取了一种个人主义的方法，在研究“自我”的思想时，在考虑“他人”的思想方面受到了限制。另一方面，对孤独的神经生理学研究主要集中在展示孤独的生物学相关性，而不是考虑孤独在代表预先存在或预期的生物需求方面的作用。在这篇文章中，我们回顾了在思想、身体和大脑层面上关于自我-他者表征的跨学科研究。我们提出了支持自我-他人重叠的神经生理机制，以异源静态-内感受性自我调节理论为指导，并位于预测加工框架中。这些发现表明，身体和大脑中的自我-他人表征可能构成了社会联系的基础，而孤独可能与自我-他人重叠不足有关。我们讨论了该模型的临床意义，特别是在边缘型人格障碍中，并以未来推进孤独研究的理论和方法考虑作为结束。

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引用次数: 0

Comorbidity of autism spectrum disorders and anxiety disorders: Insights from neuronal circuitry studies 自闭症谱系障碍和焦虑症的共病：来自神经回路研究的见解。

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2026-01-04 DOI: 10.1016/j.neubiorev.2026.106547

Jack F. Webster , Michael A. Cousin

Autism spectrum disorders are highly comorbid with anxiety disorders, with comorbid anxiety increasingly being recognised as a major cause of quality-of-life reduction for many individuals with an autism spectrum disorder. This comorbidity is underpinned by dysfunction in a group of core neural circuits which promotes the core symptomatology associated with these conditions. These circuits have been studied extensively in both humans and preclinical models, and in this review we provide an up-to-date summary of the primary circuits which control the behaviours associated with both autism spectrum disorders and anxiety disorders. These include the prefrontal cortical-amygdala circuit, the hippocampal formation, basal ganglia and the hypothalamus. We will also detail how dysfunction within these circuits converge to promote the phenotypes observed in these conditions. Finally, we propose a series of suggestions to resolve current controversies and advance knowledge towards establishing a circuit-level understanding of the relationship between these two disorders.

自闭症谱系障碍与焦虑症高度共病，而共病焦虑症日益被认为是许多自闭症谱系障碍患者生活质量下降的主要原因。这种合并症的基础是一组核心神经回路的功能障碍，这促进了与这些疾病相关的核心症状。这些回路已经在人类和临床前模型中进行了广泛的研究，在这篇综述中，我们提供了控制与自闭症谱系障碍和焦虑症相关行为的主要回路的最新总结。这些区域包括前额皮质-杏仁核回路、海马区、基底神经节和下丘脑。我们还将详细介绍这些电路中的功能障碍如何汇聚以促进在这些条件下观察到的表型。最后，我们提出了一系列建议，以解决当前的争议，并推进对这两种疾病之间关系的电路级理解。

引用次数: 0