Neuroscience and Biobehavioral Reviews最新文献

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Shared molecular signature in Alzheimer's disease and schizophrenia: A systematic review of the reelin signaling pathway

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106032

Ana Isabel Valderrama-Mantilla , Celia Martín-Cuevas , Ana Gómez-Garrido , Cristina Morente-Montilla , Benedicto Crespo-Facorro , Susana García-Cerro

The Reelin signaling pathway, particularly the RELN-APOER2-DAB1 complex, has emerged as a key contributor to the neuropathology of Alzheimer’s disease (AD) and Schizophrenia (SZ). Despite being distinct clinical conditions, these disorders exhibit similar patterns of cognitive decline, including early disruptions in synaptic function and memory impairments. Notably, individuals with SZ have a 2–4 fold increased risk of developing AD or other dementias, highlighting potential shared molecular mechanisms, and positioning Reelin as a pivotal link between them. This systematic review explores the role of Reelin and its signaling components across these disorders. In AD, Reelin disruption correlates with hallmark features such as Tau hyperphosphorylation, amyloid-beta accumulation, and cognitive deficits. In SZ, alterations in Reelin signaling, including epigenetic modifications affecting RELN expression, are linked to disruptions in neuronal development and synaptic plasticity, particularly in the parietal and prefrontal cortices. Additionally, genomic studies reveal specific RELN variants and allelic imbalances that may influence disease severity and treatment response in SZ, suggesting RELN’s role as a potential biomarker for therapeutic outcomes. Region-specific Reelin alterations in both AD and SZ suggest differing impacts yet underscore a potential common molecular origin. Our findings highlight the Reelin pathway as a molecular convergence point, warranting further investigation as a therapeutic and diagnostic target for AD, SZ, and potentially other neuropsychiatric disorders. The interplay between genetic and epigenetic regulation of RELN may provide novel insights into neurodegeneration, with implications for personalized intervention strategies in AD and SZ.

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引用次数: 0

Play makes us human. Commentary on adult and juvenile play in humans and other primates 游戏使我们成为人类。人类和其他灵长类动物的成年和少年游戏评述》。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105981

Peter Gray

引用次数: 0

Electrophysiological insights into Alzheimer's disease: A review of human and animal studies 阿尔茨海默病的电生理学研究：人类和动物研究综述。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105987

Kirsten N. Calvin-Dunn , Adam Mcneela , A. Leisgang Osse , G. Bhasin , M. Ridenour , J.W. Kinney , J.M. Hyman

This review highlights the crucial role of neuroelectrophysiology in illuminating the mechanisms underlying Alzheimer's disease (AD) pathogenesis and progression, emphasizing its potential to inform the development of effective treatments. Electrophysiological techniques provide unparalleled precision in exploring the intricate networks affected by AD, offering insights into the synaptic dysfunction, network alterations, and oscillatory abnormalities that characterize the disease. We discuss a range of electrophysiological methods, from non-invasive clinical techniques like electroencephalography and magnetoencephalography to invasive recordings in animal models. By drawing on findings from these studies, we demonstrate how electrophysiological research has deepened our understanding of AD-related network disruptions, paving the way for targeted therapeutic interventions. Moreover, we underscore the potential of electrophysiological modalities to play a pivotal role in evaluating treatment efficacy. Integrating electrophysiological data with clinical neuroimaging and longitudinal studies holds promise for a more comprehensive understanding of AD, enabling early detection and the development of personalized treatment strategies. This expanded research landscape offers new avenues for unraveling the complexities of AD and advancing therapeutic approaches.

这篇综述强调了神经电生理学在阐明阿尔茨海默病（AD）发病和进展机制中的重要作用，强调了其为开发有效治疗提供信息的潜力。电生理技术在探索阿尔茨海默病影响的复杂网络方面提供了无与伦比的精确度，提供了对该疾病特征的突触功能障碍、网络改变和振荡异常的见解。我们讨论了一系列电生理方法，从非侵入性临床技术如脑电图和脑磁图到动物模型的侵入性记录。通过借鉴这些研究的结果，我们展示了电生理学研究如何加深了我们对ad相关网络中断的理解，为有针对性的治疗干预铺平了道路。此外，我们强调电生理模式在评估治疗效果方面发挥关键作用的潜力。将电生理数据与临床神经影像学和纵向研究相结合，有望更全面地了解阿尔茨海默病，从而实现早期发现和个性化治疗策略的发展。这一扩展的研究领域为揭示阿尔茨海默病的复杂性和推进治疗方法提供了新的途径。

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引用次数: 0

How does neurochemistry affect attachment styles in humans? The role of oxytocin and the endogenous opioid system in sociotropy and autonomy – A systematic review 神经化学如何影响人类的依恋类型？催产素和内源性阿片系统在社会向性和自主性中的作用——系统综述。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105994

Anita Snowdon-Farrell , Chiara Attal , Naghmeh Nikkheslat , Carmine Pariante , Allan H. Young , Roland Zahn

Oxytocin was hypothesised to play a critical role in forming and maintaining secure attachments, shown to confer resilience against affective disorders. The endogenous opioid system has also emerged as a key player in attachment dynamics. In this pre-registered systematic review, we investigated whether individual differences in the functioning of these neurochemical systems are related to attachment styles, following PRISMA guidelines. As predicted, individuals with higher oxytocin function exhibited more secure attachment styles (p = .006, n = 12 studies) and less insecure attachment styles (p = .021, n = 16 studies). Contrary to our hypothesis, we found no association of endogenous opioid function with insecure (p = 0.549, n = 11 studies) or secure attachment styles (p = .065, n = 11 studies). The lack of association between endogenous mu-opioid function and attachment styles remains inconclusive due to inconsistencies in the neurochemical measurements and lack of eligible studies. Therefore, further investigations into the role of the endogenous opioid system in attachment styles are needed. Our findings corroborate the hypothesis that individual differences in oxytocin function relate to differences in attachment styles.

据推测，催产素在形成和维持安全依恋中起着关键作用，显示出对情感障碍的恢复能力。内源性阿片系统也在依恋动力学中扮演着关键角色。在这篇预先注册的系统综述中，我们调查了这些神经化学系统功能的个体差异是否与依恋类型有关，遵循PRISMA指南。正如预测的那样，催产素功能较高的个体表现出更安全的依恋类型(p=。006, n=12项研究)和较少的不安全依恋类型(p=。021, n=16项研究)。与我们的假设相反，我们发现内源性阿片功能与不安全（p=0.549, n=11项研究）或安全依恋风格（p=0.549）没有关联。065, n=11研究)。由于神经化学测量的不一致和缺乏合格的研究，内源性mu-阿片功能和依恋类型之间缺乏关联仍然是不确定的。因此，需要进一步研究内源性阿片系统在依恋类型中的作用。我们的研究结果证实了催产素功能的个体差异与依恋类型的差异有关的假设。

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引用次数: 0

Olfactory testing in infants with perinatal asphyxia: Enhancing encephalopathy risk stratification for future health outcomes

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106029

Serafina Perrone , Virginia Beretta , Maria Luisa Tataranno , Sidhartha Tan , Zhongjie Shi , Elena Scarpa , Valentina Dell’Orto , Sebastiano Ravenda , Chiara Petrolini , Maria Maddalena Brambilla , Paola Palanza , Eloisa Gitto , Francesco Nonnis-Marzano

Perinatal asphyxia (PA) is a leading cause of neonatal morbidity and mortality, often resulting in long-term neurodevelopmental challenges. Despite advancements in perinatal care, predicting long-term outcomes remains difficult. Early diagnosis is essential for timely interventions to reduce brain injury, with tools such as Magnetic Resonance Imaging, brain ultrasound, and emerging biomarkers playing a possible key role. Olfaction, one of the earliest senses to develop, may provide valuable insights into long-term neurodevelopmental outcomes following PA due to its intricate neural connections with regions responsible for memory, emotion, and homeostasis. Newborns demonstrate early olfactory abilities, such as recognizing maternal odors, which are vital for bonding, feeding, and emotional regulation. These responses are processed by a network of brain regions, including the olfactory bulb (OB), piriform cortex, amygdala, and orbitofrontal cortex. Hypoxic injury to these regions, particularly the OB, may disrupt olfactory processing in infants with PA, potentially affecting their cognitive and social development. Investigating the relationship between olfactory system development and perinatal brain injury could lead to innovative diagnostic and therapeutic approaches. Further research, including clinical and animal studies, is necessary to fully explore the potential of olfactory assessments in predicting outcomes after PA. This educational review explores and discusses the potential of olfaction as a predictor of long-term outcomes and a tool for risk stratification following PA, opening new pathways for interventions and improved care.

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引用次数: 0

Corrigendum to “Emotion Regulation: From neural circuits to a transdiagnostic perspective” [Neurosci. Biobehav. Rev. (2025) 168:105960] 情绪调节：从神经回路到跨诊断视角" [Neurosci. Biobehav. Rev. (2025) 168:105960] 的更正。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105998

Carmen Morawetz , Florian J. Hemetsberger , Angela R. Laird , Nils Kohn

引用次数: 0

Corrigendum to “The neural correlates of physical exercise-induced general cognitive gains: A systematic review and meta-analysis of functional magnetic resonance imaging studies” [Neurosci. Biobehav. Rev. 169 (2025) 106008]

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106025

Geng Li , Haishuo Xia , Gesi Teng , Antao Chen

引用次数: 0

Mitochondrial transplantation in brain disorders: Achievements, methods, and challenges 线粒体移植治疗脑部疾病：成就、方法和挑战。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2024.105971

Aurélien Riou , Aline Broeglin , Amandine Grimm

Mitochondrial transplantation is a new treatment strategy aimed at repairing cellular damage by introducing healthy mitochondria into injured cells. The approach shows promise in protecting brain function in various neurological disorders such as traumatic brain injury/ischemia, neurodegenerative diseases, cognitive disorders, and cancer. These conditions are often characterized by mitochondrial dysfunction, leading to impaired energy production and neuronal death. The review highlights promising preclinical studies where mitochondrial transplantation has been shown to restore mitochondrial function, reduce inflammation, and improve cognitive and motor functions in several animal models. It also addresses significant challenges that must be overcome before this therapy can be clinically applied. Current efforts to overcome these challenges, including advancements in isolation techniques, cryopreservation methods, finding an appropriate mitochondria source, and potential delivery routes, are discussed. Considering the rising incidence of neurological disorders and the limited effectiveness of current treatments, this review offers a comprehensive overview of the current state of mitochondrial transplantation research and critically assesses the remaining obstacles. It provides valuable insights that could steer future studies and potentially lead to more effective treatments for various brain disorders.

线粒体移植是一种新的治疗策略，旨在通过将健康的线粒体引入损伤细胞来修复细胞损伤。该方法有望保护各种神经系统疾病的脑功能，如创伤性脑损伤/缺血、神经退行性疾病、认知障碍和癌症。这些疾病通常以线粒体功能障碍为特征，导致能量产生受损和神经元死亡。这篇综述强调了有前景的临床前研究，在一些动物模型中，线粒体移植已被证明可以恢复线粒体功能，减少炎症，改善认知和运动功能。它还解决了该疗法在临床应用之前必须克服的重大挑战。目前克服这些挑战的努力，包括分离技术的进步，低温保存方法，寻找合适的线粒体来源，以及潜在的递送途径，讨论。考虑到神经系统疾病发病率的上升和目前治疗方法的有限有效性，本综述对线粒体移植研究的现状进行了全面概述，并对剩余的障碍进行了批判性评估。它提供了有价值的见解，可以指导未来的研究，并可能导致更有效的治疗各种脑部疾病。

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引用次数: 0

Increased atherogenicity in mood disorders: a systematic review, meta-analysis and meta-regression 情绪障碍的动脉粥样硬化性增加：系统回顾、荟萃分析和荟萃回归。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106005

Ketsupar Jirakran , Abbas F. Almulla , Thapanee Jaipinta , Asara Vasupanrajit , Priabprat Jansem , Chavit Tunvirachaisakul , Elizabet Dzhambazova , Drozdstoj St. Stoyanov , Michael Maes

Background

Major depressive disorder (MDD) and bipolar disorder (BD) often coexist with metabolic syndrome. Both are linked to increased atherogenicity and a higher risk of cardiovascular diseases. Nevertheless, a comprehensive analysis of key atherogenic biomarkers in MDD/BD is still lacking.

Objectives

This meta-analysis evaluates the relationship between atherogenic indices and MDD/BD, while identifying the most effective atherogenic biomarker.

Methods

This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched electronic databases, including PubMed, Google Scholar, and Web of Science, for articles published up to August 1, 2024.

Results

We included 85 eligible studies (14 on BD and 71 on MDD), covering 70,856 participants: 18,738 patients and 52,118 healthy controls. MDD/BD patients showed significant increases (p < 0.001) in the Castelli Risk Index 2 (CRI2), Atherogenic Index of Plasma (AIP), and (triglyceride or TG + low-density lipoprotein + very low-density lipoprotein)/(high-density lipoprotein cholesterol or HDL + Apolipoprotein A or ApoA) ratio, but not CRI1 and ApoB/ApoA ratio. Significant lower HDL and lecithin: cholesterol acyltransferase activity, and higher TG levels were observed in MDD/BD patients compared with controls. There were no significant differences between MDD and BD patients. Most included studies lacked the most essential information on the inclusion and exclusion of important confounders.

Conclusions

AIP is the most effective atherogenicity index for mood disorders. Regular lipid profiling and metabolic syndrome screening are crucial in MDD/BD. Early intervention with lipid-lowering therapies is recommended to prevent the worsening of atherogenicity and disease progression.

背景：重度抑郁障碍（MDD）和双相情感障碍（BD）常与代谢综合征共存。两者都与动脉粥样硬化性增加和心血管疾病风险增加有关。然而，对MDD/BD的关键动脉粥样硬化生物标志物的综合分析仍然缺乏。目的：本荟萃分析评估了动脉粥样硬化指标与MDD/BD之间的关系，同时确定了最有效的动脉粥样硬化生物标志物。方法：本研究遵循系统评价和荟萃分析指南的首选报告项目。我们检索了电子数据库，包括PubMed、b谷歌Scholar和Web of Science，检索了截止到2024年8月1日发表的文章。结果：我们纳入了85项符合条件的研究（14项双相障碍研究和71项重度抑郁症研究），涵盖70,856名参与者：18,738名患者和52,118名健康对照。MDD/BD患者的Castelli风险指数2 （CRI2）、血浆致动脉粥样硬化指数（AIP）和（甘油三酯或TG +低密度脂蛋白+极低密度脂蛋白）/（高密度脂蛋白胆固醇或HDL +载脂蛋白A或ApoA）比值显著升高（p < 0.001），但CRI1和ApoB/ApoA比值无显著升高。与对照组相比，MDD/BD患者的HDL和卵磷脂、胆固醇酰基转移酶活性显著降低，TG水平较高。MDD和BD患者之间无显著差异。大多数纳入的研究缺乏关于纳入和排除重要混杂因素的最基本信息。结论：AIP是诊断心境障碍最有效的动脉粥样硬化指数。定期的脂质分析和代谢综合征筛查对MDD/BD至关重要。建议采用降脂疗法进行早期干预，以防止动脉粥样硬化恶化和疾病进展。

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引用次数: 0

Levelling up the study of animal gameplay 升级动物玩法研究。

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews

Pub Date : 2025-02-01 DOI: 10.1016/j.neubiorev.2025.106016

Fay E. Clark

Play in humans and other animals is widespread and intuitive to recognise. Creative, unstructured play is difficult to quantify, but games direct play towards a specific goal and have defined rules, mechanics and rewards. To date, games have been under-utilised in human and animal behavioural neuroscience. This review evaluates evidence that animals can play human games, including game-theory contests, tangible games, and video games. Animals can be trained to play various human games with cognitive capacities such as role adoption, rule-following and performance monitoring. Animals can make irrational gameplay decisions that jeopardise rewards and have salient emotional responses to winning and losing. Games can advance the field of behavioural neuroscience in several ways. Cognitive tasks can become more engaging and ecologically relevant by adding game elements, known as gamification. Games can be used to induce and measure more naturalistic emotional responses to the process of overcoming (progression/regression) and end state (winning/losing) of cognitive challenges. There is also scope to target specific cognitive skill deficiencies in captive animals using games. However, a recent rapid increase in computerised testing environments raises an important ethical question about the boundary between games and reality for animals.

玩耍在人类和其他动物中很普遍，而且很容易识别。创造性的、非结构化的玩法很难量化，但游戏会引导玩家朝着特定目标前进，并拥有明确的规则、机制和奖励。到目前为止，游戏在人类和动物行为神经科学中的应用还不够充分。这篇综述评估了动物可以玩人类游戏的证据，包括博弈论竞赛、有形游戏和电子游戏。动物可以被训练来玩各种具有认知能力的人类游戏，如角色接受、规则遵循和表现监控。动物可能会做出非理性的游戏决策，危及奖励，并对输赢产生明显的情绪反应。游戏可以在几个方面推动行为神经科学领域的发展。通过添加游戏元素（游戏化），认知任务可以变得更具吸引力和生态相关性。游戏可以用来诱导和衡量对克服认知挑战过程（进展/倒退）和最终状态（胜利/失败）的更自然的情绪反应。游戏还可以针对圈养动物的特定认知技能缺陷。然而，最近计算机化测试环境的迅速增加引发了一个关于动物游戏与现实之间界限的重要伦理问题。

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