Pub Date : 2023-05-16DOI: 10.2174/2210315513666230516120756
P. Wal, A. Wal, M. Singh, Arpit Gupta, Shruti Rathore, Rupali Rupasmita Rout
The pumpkin, a very well-edible plant that is a member of the Cucurbitaceae family, has long been utilised as a functional food and an herbal remedy. Pumpkins include a wealth of phytoestrogens, unsaturated fatty acids, and vitamin E in their seeds that may have medicinal, nutritional, and cosmetic benefits. In recent years, knowledge of the nutritional benefits and medicinal uses of pumpkin seeds has grown significantly. An abundant source of nutrients and a well-known multipurpose food, pumpkin has recently given scientists fresh insights. Primary and secondary metabolites, such as carbohydrates, proteins, monounsaturated fatty acids, poly saturated fatty acids, carotenoids, tocopherols, tryptophan, delta-7-sterols, & numerous other phytochemicals, are abundant in the pumpkin fruit, including the meat, seed, and peel. In this review, the nutraceutical importance of pumpkin's seed anti-diabetic, hypoglycemic, cardiovascular preventive and anti-cancer effects are explored along with the nutraceutical effects of anti-depressants, anti-helminthic and anti-oxidants effects are involved. A comprehensive analysis of the literature search was conducted. A number of databases have been searched using the common terms "pumpkin,", "pumpkin seeds", "cucurbita,", "functional food", "phenolic compounds", "minerals,", and "phytochemicals" using PubMed and Google Scholar as search engines. The content was based on information from publications like Bentham Science, Elsevier, Taylor & Francis, Nature, Plos One, etc. We have focused on the review and research papers published between 2000 and 2023. Meanwhile, some research gaps on the biological activities of pumpkin seeds and their potential as a functional food element have been discovered in the current literature. The pharmacokinetics of Pumpkin seeds bioactives and the characterization and identification of functional molecules have received very little attention in the literature. It is necessary to conduct more studies to connect the pharmacodynamics and pharmacokinetics of Pumpkin seeds. The therapeutic benefits of pumpkin seeds & the potential disease-preventing mechanisms are updated in this review article, also on the chemical make-up, nutritional value, phytochemical research, pharmacological characteristics, bioavailability, food use, & industrial applications of pumpkin.
{"title":"Pumpkin Seeds (Cucurbita Sp.) As A Nutraceutical Used In Various Lifestyle Disorders","authors":"P. Wal, A. Wal, M. Singh, Arpit Gupta, Shruti Rathore, Rupali Rupasmita Rout","doi":"10.2174/2210315513666230516120756","DOIUrl":"https://doi.org/10.2174/2210315513666230516120756","url":null,"abstract":"\u0000\u0000The pumpkin, a very well-edible plant that is a member of the Cucurbitaceae family, has long been utilised as a functional food and an herbal remedy. Pumpkins include a wealth of phytoestrogens, unsaturated fatty acids, and vitamin E in their seeds that may have medicinal, nutritional, and cosmetic benefits. In recent years, knowledge of the nutritional benefits and medicinal uses of pumpkin seeds has grown significantly. An abundant source of nutrients and a well-known multipurpose food, pumpkin has recently given scientists fresh insights. Primary and secondary metabolites, such as carbohydrates, proteins, monounsaturated fatty acids, poly saturated fatty acids, carotenoids, tocopherols, tryptophan, delta-7-sterols, & numerous other phytochemicals, are abundant in the pumpkin fruit, including the meat, seed, and peel.\u0000\u0000\u0000\u0000In this review, the nutraceutical importance of pumpkin's seed anti-diabetic, hypoglycemic, cardiovascular preventive and anti-cancer effects are explored along with the nutraceutical effects of anti-depressants, anti-helminthic and anti-oxidants effects are involved.\u0000\u0000\u0000\u0000A comprehensive analysis of the literature search was conducted. A number of databases have been searched using the common terms \"pumpkin,\", \"pumpkin seeds\", \"cucurbita,\", \"functional food\", \"phenolic compounds\", \"minerals,\", and \"phytochemicals\" using PubMed and Google Scholar as search engines. The content was based on information from publications like Bentham Science, Elsevier, Taylor & Francis, Nature, Plos One, etc. We have focused on the review and research papers published between 2000 and 2023.\u0000\u0000\u0000\u0000Meanwhile, some research gaps on the biological activities of pumpkin seeds and their potential as a functional food element have been discovered in the current literature. The pharmacokinetics of Pumpkin seeds bioactives and the characterization and identification of functional molecules have received very little attention in the literature. It is necessary to conduct more studies to connect the pharmacodynamics and pharmacokinetics of Pumpkin seeds.\u0000\u0000\u0000\u0000The therapeutic benefits of pumpkin seeds & the potential disease-preventing mechanisms are updated in this review article, also on the chemical make-up, nutritional value, phytochemical research, pharmacological characteristics, bioavailability, food use, & industrial applications of pumpkin.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45049945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-15DOI: 10.2174/2210315513666230515143651
N. Desai, V. Suvarna, Niserga Sawant
Unconjugated nanoparticles used in the treatment of cancer and various metabolic and neurodegenerative disorders exhibit extended blood circulation time, inhibition of enzymatic degradation, and increased chemical stability of the encapsulated therapeutic molecules. However, the unconjugated nanoparticles often show off-target effects and lack of specificity, which limit their applications in the healthcare system. Curcumin, a polyphenolic compound known for its proficiency to scavenge reactive oxygen species attributed to antioxidant activity and anticancer effects associated with mitochondrial dysfunction, is one of the most effective therapeutic agents. Therefore, with respect to chemotherapeutic strategies, the development of mitochondrial targeting curcumin nanoparticles for target-specific drug delivery has been extensively studied. The present review has focused on diverse curcumin-loaded nanoparticles targeting mitochondria along with their improved delivery potential, enhanced localization and biodistribution profile.
{"title":"Curcumin-conjugated Nanoparticles: An Approach to Target Mitochondria","authors":"N. Desai, V. Suvarna, Niserga Sawant","doi":"10.2174/2210315513666230515143651","DOIUrl":"https://doi.org/10.2174/2210315513666230515143651","url":null,"abstract":"\u0000\u0000Unconjugated nanoparticles used in the treatment of cancer and various metabolic and neurodegenerative disorders exhibit extended blood circulation time, inhibition of enzymatic degradation, and increased chemical stability of the encapsulated therapeutic molecules. However, the unconjugated nanoparticles often show off-target effects and lack of specificity, which limit their applications in the healthcare system.\u0000\u0000\u0000\u0000Curcumin, a polyphenolic compound known for its proficiency to scavenge reactive oxygen species attributed to antioxidant activity and anticancer effects associated with mitochondrial dysfunction, is one of the most effective therapeutic agents. Therefore, with respect to chemotherapeutic strategies, the development of mitochondrial targeting curcumin nanoparticles for target-specific drug delivery has been extensively studied.\u0000\u0000\u0000\u0000The present review has focused on diverse curcumin-loaded nanoparticles targeting mitochondria along with their improved delivery potential, enhanced localization and biodistribution profile.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41657449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.2174/2210315513666230510123728
J. Ombito, Gomotsang Bojase
The genus Securidaca (Polygalaceae) comprises 49 taxonomically accepted species distributed in Asia and Africa. The roots, barks, and leaves of Securidaca species are famous for medicinal purposes, especially in Africa and Asia. In this paper, we review the xanthones isolated from S. inappendiculata and S. longepedunculata, the two main species that have been investigated and the bioactivities of these compounds to evaluate the traditional use of these plant species and future development. The references regarding Securidaca species were retrieved from Scopus, Web of Science, PubMed, ScienceDirect, Google Scholar, and SciFinder between 1990 and 2022. Chemical structures of more than 70 xanthones isolated mainly from the stems and roots of S. inappendiculata and S. longepedunculata are presented. These xanthones might be responsible for the ethnomedicinal uses reported in the literature based on the exhibited biological properties such as cytotoxic, antidiabetic, antiviral, and erectile dysfunction of these compounds. Reviewing the research progress made on the isolated xanthones from the genus Securidaca lays a foundation for the future utilization and development of this genus.
凤仙花属(凤仙花科)共有49种，分布在亚洲和非洲。Securidaca的根、树皮和叶子以药用而闻名，特别是在非洲和亚洲。本文综述了近年来研究的两种主要植物荆芥和长柄荆芥中所分离到的山酮类化合物及其生物活性，并对其传统用途和未来开发前景进行了展望。检索了1990 ~ 2022年Scopus、Web of Science、PubMed、ScienceDirect、b谷歌Scholar和SciFinder中有关Securidaca的文献。本文报道了主要从无尾草和长柄草的茎和根中分离得到的70多种山酮类化合物的化学结构。根据这些化合物所显示的生物学特性，如细胞毒性、抗糖尿病、抗病毒和勃起功能障碍，这些山酮可能是文献中报道的民族医学用途的原因。综述了国内外对山仙子山酮类分离物的研究进展，为山仙子山酮的进一步开发利用奠定了基础。
{"title":"Xanthones from Securidaca inappendiculata and Securidaca longepedunculata: Chemistry and Biological Activity","authors":"J. Ombito, Gomotsang Bojase","doi":"10.2174/2210315513666230510123728","DOIUrl":"https://doi.org/10.2174/2210315513666230510123728","url":null,"abstract":"\u0000\u0000The genus Securidaca (Polygalaceae) comprises 49 taxonomically accepted species distributed in Asia and Africa. The roots, barks, and leaves of Securidaca species are famous for medicinal purposes, especially in Africa and Asia. In this paper, we review the xanthones isolated from S. inappendiculata and S. longepedunculata, the two main species that have been investigated and the bioactivities of these compounds to evaluate the traditional use of these plant species and future development. The references regarding Securidaca species were retrieved from Scopus, Web of Science, PubMed, ScienceDirect, Google Scholar, and SciFinder between 1990 and 2022. Chemical structures of more than 70 xanthones isolated mainly from the stems and roots of S. inappendiculata and S. longepedunculata are presented. These xanthones might be responsible for the ethnomedicinal uses reported in the literature based on the exhibited biological properties such as cytotoxic, antidiabetic, antiviral, and erectile dysfunction of these compounds. Reviewing the research progress made on the isolated xanthones from the genus Securidaca lays a foundation for the future utilization and development of this genus.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44410720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-02DOI: 10.2174/2210315513666230502104141
M. Bajpai, Aastha Sharma, Keshav Bansal
Polycystic ovary syndrome (PCOS/PCOD) indicates a common, multifactorial endocrine condition marked by polycystic ovaries, chronic anovulation, and hyperandrogenism, resulting in asymmetric menstrual periods, hirsutism, acne, and infertility. Standard treatment for PCOS is often accompanied by adverse effects, and is ineffective in certain situations, refutation-based medical guidance accented an integrative progress. Furthermore, women suffering from PCOS may benefit from alternative treatments. Herbal treatment includes herbs that have a phytoestrogenic and non-estrogenic nature, including Mentha spicata, Panax ginseng, Glycyrrhiza glabra, Aloe barbadensis, Cinnamomum zeylanicum, Matricaria chamomilla, Trigonella foenum-graecum, Linum usitatissimum, and Zingiber officinale, which are effective and safe. This review focuses on the reproductive endocrine effects of phytomedicine as a choice treatment so as to PCOD and accompanying oligo/amenorrhoea, acne, hirsutism, and infertility.
{"title":"The Role of Different Medicinal Herbs in Treatment of Polycystic Ovary\u0000Syndrome: A Review","authors":"M. Bajpai, Aastha Sharma, Keshav Bansal","doi":"10.2174/2210315513666230502104141","DOIUrl":"https://doi.org/10.2174/2210315513666230502104141","url":null,"abstract":"\u0000\u0000Polycystic ovary syndrome (PCOS/PCOD) indicates a common, multifactorial endocrine condition\u0000marked by polycystic ovaries, chronic anovulation, and hyperandrogenism, resulting in asymmetric\u0000menstrual periods, hirsutism, acne, and infertility. Standard treatment for PCOS is often accompanied by\u0000adverse effects, and is ineffective in certain situations, refutation-based medical guidance accented an\u0000integrative progress. Furthermore, women suffering from PCOS may benefit from alternative treatments.\u0000Herbal treatment includes herbs that have a phytoestrogenic and non-estrogenic nature, including Mentha\u0000spicata, Panax ginseng, Glycyrrhiza glabra, Aloe barbadensis, Cinnamomum zeylanicum, Matricaria\u0000chamomilla, Trigonella foenum-graecum, Linum usitatissimum, and Zingiber officinale, which are effective\u0000and safe. This review focuses on the reproductive endocrine effects of phytomedicine as a choice\u0000treatment so as to PCOD and accompanying oligo/amenorrhoea, acne, hirsutism, and infertility.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46904555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.2174/2210315513666230428113918
M. Ahadi, P. Astaraki
Herbal medicines have long been used in therapeutic medicine owing to their minimal side effects. However, contamination, inadequate purification, and adulteration can lead to adverse outcomes upon intake. Several forensic case studies have reported that these compounds can be overdosed, leading to serious effects and death. Furthermore, their interactions with pharmacological agents are poorly studied. In forensic settings, mass spectrometry along with liquid chromatography is the most practiced method to detect and quantity these agents.
{"title":"Potential disorders caused by traditional herbal medicines based on forensic case studies","authors":"M. Ahadi, P. Astaraki","doi":"10.2174/2210315513666230428113918","DOIUrl":"https://doi.org/10.2174/2210315513666230428113918","url":null,"abstract":"\u0000\u0000Herbal medicines have long been used in therapeutic medicine owing to their minimal side\u0000effects. However, contamination, inadequate purification, and adulteration can lead to adverse outcomes\u0000upon intake. Several forensic case studies have reported that these compounds can be overdosed, leading\u0000to serious effects and death. Furthermore, their interactions with pharmacological agents are poorly studied. In forensic settings, mass spectrometry along with liquid chromatography is the most practiced method to detect and quantity these agents.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42759593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-28DOI: 10.2174/2210315513666230428113707
T. Duminis
Natural polymers, such as chitosan (CH) and gelatine (GE), have a wide range of uses in biological environments. This is primarily attributed to their biocompatibility and the body’s recognition of them being as “self” as opposed to “foreign”. These polymers provide a dynamic and cell-friendly interaction environment which is a crucial factor for tissue repair and regeneration. Bone regeneration is a highly intricate multistep process involving a plethora of biomolecules, signalling pathways, and stages in cellular activity. Critically-sized bone defects do not regenerate without an implant due to the cessation of the cellular stimulus associated with new bone formation. Therefore, natural polymers have been combined with bioactive glasses (BGs) to provide a biocompatible delivery matrix and to stimulate bone formation via the release of osteogenic ions from the BG particles. The addition of BG particles in natural polymers has been shown not only to result in an osteogenic response at a cellular level but also result in per se formation of hydroxyapatite (HA) on implant surfaces and regeneration of new bone in vivo. This review discusses the recent trends over the last decade in this field, keeping a focus on the chemistry and properties of CH and GE composites containing a bioactive glass additive.
{"title":"Natural Polymers with Bioactive Glass Additives for Bone Regeneration: Chemistry and Trends","authors":"T. Duminis","doi":"10.2174/2210315513666230428113707","DOIUrl":"https://doi.org/10.2174/2210315513666230428113707","url":null,"abstract":"\u0000\u0000Natural polymers, such as chitosan (CH) and gelatine (GE), have a wide range of uses in biological environments. This is primarily attributed to their biocompatibility and the body’s recognition of\u0000them being as “self” as opposed to “foreign”. These polymers provide a dynamic and cell-friendly interaction environment which is a crucial factor for tissue repair and regeneration. Bone regeneration is a\u0000highly intricate multistep process involving a plethora of biomolecules, signalling pathways, and stages in\u0000cellular activity. Critically-sized bone defects do not regenerate without an implant due to the cessation of\u0000the cellular stimulus associated with new bone formation. Therefore, natural polymers have been combined with bioactive glasses (BGs) to provide a biocompatible delivery matrix and to stimulate bone formation via the release of osteogenic ions from the BG particles. The addition of BG particles in natural\u0000polymers has been shown not only to result in an osteogenic response at a cellular level but also result in\u0000per se formation of hydroxyapatite (HA) on implant surfaces and regeneration of new bone in vivo. This\u0000review discusses the recent trends over the last decade in this field, keeping a focus on the chemistry and\u0000properties of CH and GE composites containing a bioactive glass additive.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48077971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-27DOI: 10.2174/2210315513666230427153251
B. Semwal, A. Hussain, Sonia Singh
Lithospermic acid is a phenylpropanoid oligomer isolated from an aqueous extract of dried roots of various Lamiaceae and Boraginaceae plants and used as a folk medicine to treat cardiovascular disease and to improve body functions. The manuscript has been written to provide valuable insights into naturally occurring phytocomponent, Lithospermic acid, and even explore its therapeutic potential. The data have been gathered from books and web sources, including Science Direct, Publons, Web of Science, and Scopus of the latest year. Lithospermic acid is a conjugate of rosmarinic and caffeic acid with a dihydro benzofuran nucleus and possesses a high antioxidant potential and prevents the production of superoxide radicals and lipid peroxidation and protects the tissue from deleterious effects of reactive oxygen species. In addition, it also possesses a wide range of pharmacological activities, including reducing atherosclerosis, anti-inflammatory, hepatoprotective, anti-viral, HIV-1 integrase, and hyaluronidase inhibition, aldose reductase inhibition and improvement in uremic symptoms guanidino succinic acid level. Due to its anti-HIV activity, LA has gained much attention among the scientific community. Moreover, it is widely distributed to all the peripheral tissue in rats, and its metabolites undergo enterohepatic circulation and are excreted through biliary excretion. In this review, we concluded LA with its phytochemistry, pharmacokinetics, and pharmacological activities
紫草酸是一种苯丙素低聚物，从各种兰科和琉璃苣科植物的干根的水提取物中分离出来，作为民间药物用于治疗心血管疾病和改善身体功能。该手稿的撰写是为了提供对天然存在的植物成分紫草酸的有价值的见解，甚至探索其治疗潜力。这些数据是从书籍和网络资源中收集的，包括Science Direct、Publons、web of Science和Scopus最近一年的数据。紫菀酸是迷迭香和咖啡酸与二氢苯并呋喃核的结合物，具有很高的抗氧化潜力，可防止超氧自由基和脂质过氧化的产生，并保护组织免受活性氧的有害影响。此外，它还具有广泛的药理活性，包括降低动脉粥样硬化、抗炎、保肝、抗病毒、抑制HIV-1整合酶以及抑制透明质酸酶、醛糖还原酶和改善尿毒症症状的胍丁二酸水平。由于其抗hiv的活性，LA受到了科学界的广泛关注。此外，它广泛分布于大鼠的所有外周组织，其代谢产物经肠肝循环并通过胆道排泄。本文对其植物化学、药代动力学和药理活性进行了综述
{"title":"An Overview on Naturally Occurring Phytoconstituent: Lithospermic acid","authors":"B. Semwal, A. Hussain, Sonia Singh","doi":"10.2174/2210315513666230427153251","DOIUrl":"https://doi.org/10.2174/2210315513666230427153251","url":null,"abstract":"\u0000\u0000Lithospermic acid is a phenylpropanoid oligomer isolated from an aqueous extract of dried roots of various Lamiaceae and Boraginaceae plants and used as a folk medicine to treat cardiovascular disease and to improve body functions.\u0000\u0000\u0000\u0000The manuscript has been written to provide valuable insights into naturally occurring phytocomponent, Lithospermic acid, and even explore its therapeutic potential.\u0000\u0000\u0000\u0000The data have been gathered from books and web sources, including Science Direct, Publons, Web of Science, and Scopus of the latest year.\u0000\u0000\u0000\u0000Lithospermic acid is a conjugate of rosmarinic and caffeic acid with a dihydro benzofuran nucleus and possesses a high antioxidant potential and prevents the production of superoxide radicals and lipid peroxidation and protects the tissue from deleterious effects of reactive oxygen species. In addition, it also possesses a wide range of pharmacological activities, including reducing atherosclerosis, anti-inflammatory, hepatoprotective, anti-viral, HIV-1 integrase, and hyaluronidase inhibition, aldose reductase inhibition and improvement in uremic symptoms guanidino succinic acid level. Due to its anti-HIV activity, LA has gained much attention among the scientific community. Moreover, it is widely distributed to all the peripheral tissue in rats, and its metabolites undergo enterohepatic circulation and are excreted through biliary excretion.\u0000\u0000\u0000\u0000In this review, we concluded LA with its phytochemistry, pharmacokinetics, and pharmacological activities\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46614650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.2174/2210315513666230418104500
Shikha Yadav, Javed Khan, Aftab Alam
Acute kidney injury is described as a loss of renal excretory function that occurs suddenly. AKI is one of several ailments grouped together as acute kidney diseases and disorders (AKD), in which progressive degradation of kidney function or persistent renal dysfunction is associated with irreversible loss of kidney cells and nephrons, potentially leading to chronic kidney disease (CKD). The prevalence and incidence of KDs are assessed in light of population disparities in the prevalence of risk factors such as diabetes, hypertension, and obesity. However, the presence of these associated illnesses does not fully explain the increased rate of progression of chronic renal disease in high-risk patients (CKD). The development of renal disease is accompanied by a decline in renal function, which eventually leads to renal failure. The current status of diagnostic testing does not allow for accurate early disease diagnosis, prognosis, or therapy efficacy monitoring. Despite significant advances in care and understanding of the causes of acute renal failure (ARF), many aspects of ARF remain controversial, confusing, and uncertain. Accurate information on the disease's prevalence, genesis, and clinical manifestations is required to successfully advocate for enough funding and resources to manage the disease. Herbal components for the treatment of a variety of kidney disorders, and the page includes a list of plants that are good for kidney treatment. This review focuses on several herbal products used to treat renal problems. It is clear from this study that medicinal plants play an important role in the fight against many different diseases. Several different plants and plant extracts have been shown to have beneficial effects in treating renal disease. These medications have great promise for use in treating kidney damage because of their nephroprotective, cytoprotective, immunomodulatory, antioxidant, anti-inflammatory, and reducing effects on oxidative stress, renal hypertension, and blood toxins such as urea, creatinine, and others. Therefore, India's traditional medicine offers a wide variety of medications that can be utilized in renal illnesses due to their effectiveness in both treating the ailment and restoring normal kidney function. Therefore, it is suggested that additional research be conducted to learn many aspects and mechanisms of medications.
{"title":"Herbal Components for the Treatment of Various Kidney Disorders","authors":"Shikha Yadav, Javed Khan, Aftab Alam","doi":"10.2174/2210315513666230418104500","DOIUrl":"https://doi.org/10.2174/2210315513666230418104500","url":null,"abstract":"\u0000\u0000Acute kidney injury is described as a loss of renal excretory function that occurs suddenly. AKI is one of several ailments grouped together as acute kidney diseases and disorders (AKD), in which progressive degradation of kidney function or persistent renal dysfunction is associated with irreversible loss of kidney cells and nephrons, potentially leading to chronic kidney disease (CKD). The prevalence and incidence of KDs are assessed in light of population disparities in the prevalence of risk factors such as diabetes, hypertension, and obesity. However, the presence of these associated illnesses does not fully explain the increased rate of progression of chronic renal disease in high-risk patients (CKD). The development of renal disease is accompanied by a decline in renal function, which eventually leads to renal failure. The current status of diagnostic testing does not allow for accurate early disease diagnosis, prognosis, or therapy efficacy monitoring. Despite significant advances in care and understanding of the causes of acute renal failure (ARF), many aspects of ARF remain controversial, confusing, and uncertain. Accurate information on the disease's prevalence, genesis, and clinical manifestations is required to successfully advocate for enough funding and resources to manage the disease. Herbal components for the treatment of a variety of kidney disorders, and the page includes a list of plants that are good for kidney treatment. This review focuses on several herbal products used to treat renal problems.\u0000\u0000\u0000\u0000It is clear from this study that medicinal plants play an important role in the fight against many different diseases. Several different plants and plant extracts have been shown to have beneficial effects in treating renal disease. These medications have great promise for use in treating kidney damage because of their nephroprotective, cytoprotective, immunomodulatory, antioxidant, anti-inflammatory, and reducing effects on oxidative stress, renal hypertension, and blood toxins such as urea, creatinine, and others. Therefore, India's traditional medicine offers a wide variety of medications that can be utilized in renal illnesses due to their effectiveness in both treating the ailment and restoring normal kidney function. Therefore, it is suggested that additional research be conducted to learn many aspects and mechanisms of medications.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42050827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since ancient times, traditional herbs have been widely used around the world for health promotion and therapy. Obesity is a complex metabolic disorder and is becoming a mammoth problem that adversely affects an individual’s quality of life. Conventional therapy for the management of obesity mainly involves the use of synthetic moiety and bariatric surgical procedures which has severe side effects and patient non-compliance. To circumvent these limitations, plant-derived medicines are utilized which are safe, effective, economic, and easily available. The advancement of nanotechnology enables the development of novel strategies that could potentiate the therapeutic efficacy of the phytoconstituents with minimal toxic effects and promotes the controlled release of the plant bioactive compounds. Moreover, great efforts have been made through targeted nanotechnology-based herbal treatment, where novel nanocarriers are employed as herbal drug delivery vehicles to improve the pharmacokinetics of anti-obesity drugs. The recent advancement in phytonanotechnology have opened an avenue to explore novel carriers to utilize bioactive compounds in biomedical and therapeutic applications. In the current review, an extensive search is conducted for the existing original research articles using databases i.e., Google Scholar, PubMed, ScienceDirect, Embase, Baidu, etc. Further, painstaking efforts are made to compile and update the novel herbal nanocarriers such as liposomes, solid lipid nanoparticles, etc. which are widely used for the treatment of obesity. This article portrays a comprehensive survey of the novel strategies employed by the innovators working exclusively on herbal drug delivery systems. The recent development of nanotechnology-based herbal drug delivery has a wide range of biomedical applications and has provided an unprecedented opportunity to improve the treatment of obesity and obesity-related comorbidities. Furthermore, the advancement of phytopharmacological science has led to several novel strategies with improved nanotherapeutics for the management of obesity. Scientific research is still being carried out in the field of nanotechnology for a better perspective on herbal drug delivery for obesity treatment over conventional therapy.
{"title":"A Review on Nanotechnology Mediated - Herbal Drug Delivery for the Treatment of Obesity","authors":"Dipthi Shree, Chinam Niranjan Patra, Biswa Mohan Sahoo","doi":"10.2174/2210315513666230412111914","DOIUrl":"https://doi.org/10.2174/2210315513666230412111914","url":null,"abstract":"\u0000\u0000Since ancient times, traditional herbs have been widely used around the world for health promotion and therapy. Obesity is a complex metabolic disorder and is becoming a mammoth problem that adversely affects an individual’s quality of life. Conventional therapy for the management of obesity mainly involves the use of synthetic moiety and bariatric surgical procedures which has severe side effects and patient non-compliance. To circumvent these limitations, plant-derived medicines are utilized which are safe, effective, economic, and easily available. The advancement of nanotechnology enables the development of novel strategies that could potentiate the therapeutic efficacy of the phytoconstituents with minimal toxic effects and promotes the controlled release of the plant bioactive compounds. Moreover, great efforts have been made through targeted nanotechnology-based herbal treatment, where novel nanocarriers are employed as herbal drug delivery vehicles to improve the pharmacokinetics of anti-obesity drugs.\u0000\u0000\u0000\u0000The recent advancement in phytonanotechnology have opened an avenue to explore novel carriers to utilize bioactive compounds in biomedical and therapeutic applications. In the current review, an extensive search is conducted for the existing original research articles using databases i.e., Google Scholar, PubMed, ScienceDirect, Embase, Baidu, etc. Further, painstaking efforts are made to compile and update the novel herbal nanocarriers such as liposomes, solid lipid nanoparticles, etc. which are widely used for the treatment of obesity. This article portrays a comprehensive survey of the novel strategies employed by the innovators working exclusively on herbal drug delivery systems.\u0000\u0000\u0000\u0000The recent development of nanotechnology-based herbal drug delivery has a wide range of biomedical applications and has provided an unprecedented opportunity to improve the treatment of obesity and obesity-related comorbidities. Furthermore, the advancement of phytopharmacological science has led to several novel strategies with improved nanotherapeutics for the management of obesity. Scientific research is still being carried out in the field of nanotechnology for a better perspective on herbal drug delivery for obesity treatment over conventional therapy.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49387461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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