Pub Date : 2023-10-13DOI: 10.2174/0122103155253664231010070548
Li De Su, Bater Hurile, Lumen Chao, Chula San, Yu Dong, leng Amgu, Jianhui Hao, Xin Li
Objective: This study aimed to investigate the antipyretic and anti-inflammatory effects and mechanisms of Sanchen Pediatric antipyretic Paste (SPAP). background: Fever is regarded as a physiological defense phenomenon of the body against diseases to a certain extent, and it can prevent the risk of infection. However, if fever goes beyond a certain range or a high fever status lasts for a long time, it can not only reduce the immunity of human body, but also cause serious damage to various organs and tissues. Especially for infants and young children, the disease develops rapidly, which is easy to induce convulsions and even cause irreversible harm. Western medicine has a quick antipyretic effect, but it has certain side effects on children, especially infants.According to the clinical theory of traditional Mongolian medicine, Sanchen Pill is effective in treating infantile febrile diseases with low side effects. In this study, Sanchen Pill was modified into gel paste with high compliance for children and named as Sanchen Pediatric antipyretic paste (SPAP). Methods: Rats were randomly divided into 7 groups: negative control group, positive control group, positive treatment group, SPAP high-dose, medium-dose and low-dose groups, and blank substrate group. Except normal control group, rats in other groups were subcutaneously injected with 10% dry yeast suspension (10mL/kg) on the back to establish a fever model, and the normal group was given the same volume of saline. At the 4 h and 7 h after modeling, each treatment group was subjected to corresponding SPAP intervention. Anal temperature was measured every one hour after modeling for 10 consecutive times. The average temperature-rise curve, maximum temperature and body temperature response index (TRI) were calculated to evaluate the efficacy of SPAP. After the last temperature measurement, abdominal aortic blood was collected, and serum was separated from blood. The levels of IL-6, TNF-α and CRP in serum were determined by enzyme-linked immunosorbent assay. Results: The body temperature of the positive control group was significantly increased (p < 0.01) 4 hours after model establishment, and that of the SPAP groups significantly decreased (p < 0.01) after 5 hours of the model establishment. The levels of Serum IL-6, TNF-α and CRP were significantly decreased (p < 0.01) in a dose-dependent manner. Conclusion: SPAP has an obvious antipyretic effect on fever caused by dry yeast in rats. One of its antipyretic mechanisms may be associated with inhibiting inflammatory reactions by reducing the production or accelerating the degradation of endogenous thermogenic cytokines, such as IL-6, TNF- α, and CRP. result: The body temperature of the positive control group was significantly increased (p < 0.01) 4 hours after model establishment, and that of the SPAP groups were significantly decreased (p < 0.01) after 5 hours of model establishment, the levels of Serum IL-6, TNF-α and CRP were signi
{"title":"Antipyretic and Anti-inflammatory Effects of Sanchen Pediatric Antipyretic Paste","authors":"Li De Su, Bater Hurile, Lumen Chao, Chula San, Yu Dong, leng Amgu, Jianhui Hao, Xin Li","doi":"10.2174/0122103155253664231010070548","DOIUrl":"https://doi.org/10.2174/0122103155253664231010070548","url":null,"abstract":"Objective: This study aimed to investigate the antipyretic and anti-inflammatory effects and mechanisms of Sanchen Pediatric antipyretic Paste (SPAP). background: Fever is regarded as a physiological defense phenomenon of the body against diseases to a certain extent, and it can prevent the risk of infection. However, if fever goes beyond a certain range or a high fever status lasts for a long time, it can not only reduce the immunity of human body, but also cause serious damage to various organs and tissues. Especially for infants and young children, the disease develops rapidly, which is easy to induce convulsions and even cause irreversible harm. Western medicine has a quick antipyretic effect, but it has certain side effects on children, especially infants.According to the clinical theory of traditional Mongolian medicine, Sanchen Pill is effective in treating infantile febrile diseases with low side effects. In this study, Sanchen Pill was modified into gel paste with high compliance for children and named as Sanchen Pediatric antipyretic paste (SPAP). Methods: Rats were randomly divided into 7 groups: negative control group, positive control group, positive treatment group, SPAP high-dose, medium-dose and low-dose groups, and blank substrate group. Except normal control group, rats in other groups were subcutaneously injected with 10% dry yeast suspension (10mL/kg) on the back to establish a fever model, and the normal group was given the same volume of saline. At the 4 h and 7 h after modeling, each treatment group was subjected to corresponding SPAP intervention. Anal temperature was measured every one hour after modeling for 10 consecutive times. The average temperature-rise curve, maximum temperature and body temperature response index (TRI) were calculated to evaluate the efficacy of SPAP. After the last temperature measurement, abdominal aortic blood was collected, and serum was separated from blood. The levels of IL-6, TNF-α and CRP in serum were determined by enzyme-linked immunosorbent assay. Results: The body temperature of the positive control group was significantly increased (p < 0.01) 4 hours after model establishment, and that of the SPAP groups significantly decreased (p < 0.01) after 5 hours of the model establishment. The levels of Serum IL-6, TNF-α and CRP were significantly decreased (p < 0.01) in a dose-dependent manner. Conclusion: SPAP has an obvious antipyretic effect on fever caused by dry yeast in rats. One of its antipyretic mechanisms may be associated with inhibiting inflammatory reactions by reducing the production or accelerating the degradation of endogenous thermogenic cytokines, such as IL-6, TNF- α, and CRP. result: The body temperature of the positive control group was significantly increased (p &lt; 0.01) 4 hours after model establishment, and that of the SPAP groups were significantly decreased (p &lt; 0.01) after 5 hours of model establishment, the levels of Serum IL-6, TNF-α and CRP were signi","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135922776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.2174/0122103155257513231006050509
Ali Sharifi-Rigi, Esfandiar Heidarian, Fatemeh Zal
Background: The pesticide paraquat is hazardous to both humans and animals. Lung damage is a common complication of paraquat poisoning. Objective: This research analyzes the preventive properties of Origanum vulgare leaf extract against paraquat-induced acute pulmonary toxicity and oxidative stress. Methods: In this experiment, the rats were assigned to five distinct groups. Group 1 served as the control, group 2 got only 25 mg/kg bw paraquat, and groups 3, 4, and 5 received paraquat and Origanum vulgare leaf extract at dosages of 200, 400, and 800 mg/kg bw, respectively. In rats, inflammation- related indicators and oxidative stress were analyzed after therapy. Results: Compared with the control group, the levels of the serum PC, MDA, and inflammatory markers such as TNF-α, IL-6, and IL-1β remarkably rose (p < 0.05) and the pulmonary contents of the SOD, CAT, and vitamin C greatly decreased (p < 0.05) in the paraquat-only group. Origanum vulgare leaf extract administration after paraquat exposure resulted in a substantial increase in lung SOD, CAT, and vitamin C levels as well as a significant reduction in MDA, PC, and lung inflammatory markers (TNF-α, IL-6, and IL-1β) gene expression relative to the paraquat-only group. Conclusion: Origanum vulgare leaf extract might be supplied to lessen the toxicity of paraquat, based on the findings of this research, which indicated that Origanum vulgare leaf extract has antioxidant- enhancing properties and can improve the antioxidant defense system. other: Ethic number: IR. SKUMS. REC. 1395. 151.
{"title":"Protective Effects of Hydroalcoholic Leaf Extract of Origanum Vulgare against Paraquat-induced Lung Toxicity in Rats: The Role of the Inflammation-related Markers and Oxidative Stress","authors":"Ali Sharifi-Rigi, Esfandiar Heidarian, Fatemeh Zal","doi":"10.2174/0122103155257513231006050509","DOIUrl":"https://doi.org/10.2174/0122103155257513231006050509","url":null,"abstract":"Background: The pesticide paraquat is hazardous to both humans and animals. Lung damage is a common complication of paraquat poisoning. Objective: This research analyzes the preventive properties of Origanum vulgare leaf extract against paraquat-induced acute pulmonary toxicity and oxidative stress. Methods: In this experiment, the rats were assigned to five distinct groups. Group 1 served as the control, group 2 got only 25 mg/kg bw paraquat, and groups 3, 4, and 5 received paraquat and Origanum vulgare leaf extract at dosages of 200, 400, and 800 mg/kg bw, respectively. In rats, inflammation- related indicators and oxidative stress were analyzed after therapy. Results: Compared with the control group, the levels of the serum PC, MDA, and inflammatory markers such as TNF-α, IL-6, and IL-1β remarkably rose (p < 0.05) and the pulmonary contents of the SOD, CAT, and vitamin C greatly decreased (p < 0.05) in the paraquat-only group. Origanum vulgare leaf extract administration after paraquat exposure resulted in a substantial increase in lung SOD, CAT, and vitamin C levels as well as a significant reduction in MDA, PC, and lung inflammatory markers (TNF-α, IL-6, and IL-1β) gene expression relative to the paraquat-only group. Conclusion: Origanum vulgare leaf extract might be supplied to lessen the toxicity of paraquat, based on the findings of this research, which indicated that Origanum vulgare leaf extract has antioxidant- enhancing properties and can improve the antioxidant defense system. other: Ethic number: IR. SKUMS. REC. 1395. 151.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136058491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.2174/0122103155271537231006074854
Khushbu Yadav, Anjna Rani, Kamal Dua
Background: Depression is a psychiatric and mood disorder that impacts a person's mental health and behavior and is frequently linked to suicide. As per the World Health Organization's estimate, depressive disorder will be the main cause of mental disorders by the year 2030, and it has a huge impact on the burden of disease in the world. To treat depression, there are pharmacological and nonpharmacological therapy alternatives. With little to no consideration of other neurochemicals altered in depression, most antidepressant preparations are based on the monoamines, neuroendocrine, and neuro-inflammation concepts. Objective: The present study aims to provide comprehensive data related to depression, the factors associated, the mechanism involved, herbal plants effective for managing depression, and novel formulations along with patents and clinical trials. Methods: A thorough assessment of herbs and novel formulations that have been proven effective in treating depression was conducted. After extensive review, the present study includes a mechanism of action of herbal plants showing antidepressant effects, novel formulations, patents, and clinical trials related to depression. Results: Numerous studies reported that diverse herbal plants have been found to have a positive effect on depression management, such as Panax ginseng, Melissa officinalis, Piper methysticum, Schinus molle L, Kielmeyera coriacea Mart, Elaeocarpus ganitrus, Hypericum perforatum, Lavandula angustifolia Mill, Crocus Sativus L. Conclusion: Herbal plant research could help establish the potential of isolated compounds from plants with medicinal properties for managing depressive illnesses.
{"title":"Potential Herbal Remedies for Treatment of Depression: A Mini Review","authors":"Khushbu Yadav, Anjna Rani, Kamal Dua","doi":"10.2174/0122103155271537231006074854","DOIUrl":"https://doi.org/10.2174/0122103155271537231006074854","url":null,"abstract":"Background: Depression is a psychiatric and mood disorder that impacts a person's mental health and behavior and is frequently linked to suicide. As per the World Health Organization's estimate, depressive disorder will be the main cause of mental disorders by the year 2030, and it has a huge impact on the burden of disease in the world. To treat depression, there are pharmacological and nonpharmacological therapy alternatives. With little to no consideration of other neurochemicals altered in depression, most antidepressant preparations are based on the monoamines, neuroendocrine, and neuro-inflammation concepts. Objective: The present study aims to provide comprehensive data related to depression, the factors associated, the mechanism involved, herbal plants effective for managing depression, and novel formulations along with patents and clinical trials. Methods: A thorough assessment of herbs and novel formulations that have been proven effective in treating depression was conducted. After extensive review, the present study includes a mechanism of action of herbal plants showing antidepressant effects, novel formulations, patents, and clinical trials related to depression. Results: Numerous studies reported that diverse herbal plants have been found to have a positive effect on depression management, such as Panax ginseng, Melissa officinalis, Piper methysticum, Schinus molle L, Kielmeyera coriacea Mart, Elaeocarpus ganitrus, Hypericum perforatum, Lavandula angustifolia Mill, Crocus Sativus L. Conclusion: Herbal plant research could help establish the potential of isolated compounds from plants with medicinal properties for managing depressive illnesses.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136058493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-12DOI: 10.2174/0122103155272968231003030032
Pratiksha Sharma, Varinder Singh, Ashish Baldi
Abstract: Metabolic syndrome (MS) represents a complex cluster of medical conditions with profound implications for global public health. This constellation of disorders substantially increases the susceptibility to type 2 diabetes, obesity, thrombosis, cardiovascular disease, and hyperlipidemia. The drugs currently prescribed for managing MS offer limited efficacy, likely due to their limited scope of action. Owing to their restricted mechanisms of action, these medications often lead to significant side effects such as weight gain, bone marrow impairment, Raynaud's phenomenon, galactorrhea, and others. Consequently, these adverse effects contribute to poor patient adherence and restrict the overall effectiveness of the treatment. Thus, developing new therapeutic strategies for managing MS is certainly required. Recent investigations have been concentrated on formulating strategies that combine conventional synthetic drugs with herbal medicines (which act via multiple targets), aiming to enhance treatment efficacy and enhance patient adherence in the management of MS. This concept of combining synthetic and herbal drugs is termed ‘Allo-polyherbal’ and has been shown to improve the efficacy of synthetic drugs and reduction of adverse effects. The present review uncovers the concept of Allo-polyherbal and reveals the potential benefits of using Allopolyherbal in managing diabetes, cardiovascular, hypertension, hyperlipidemia, obesity, and thrombosis leading to MS.
{"title":"Allo-polyherbal Approaches for Managing Metabolic Syndrome: A Narrative Review","authors":"Pratiksha Sharma, Varinder Singh, Ashish Baldi","doi":"10.2174/0122103155272968231003030032","DOIUrl":"https://doi.org/10.2174/0122103155272968231003030032","url":null,"abstract":"Abstract: Metabolic syndrome (MS) represents a complex cluster of medical conditions with profound implications for global public health. This constellation of disorders substantially increases the susceptibility to type 2 diabetes, obesity, thrombosis, cardiovascular disease, and hyperlipidemia. The drugs currently prescribed for managing MS offer limited efficacy, likely due to their limited scope of action. Owing to their restricted mechanisms of action, these medications often lead to significant side effects such as weight gain, bone marrow impairment, Raynaud's phenomenon, galactorrhea, and others. Consequently, these adverse effects contribute to poor patient adherence and restrict the overall effectiveness of the treatment. Thus, developing new therapeutic strategies for managing MS is certainly required. Recent investigations have been concentrated on formulating strategies that combine conventional synthetic drugs with herbal medicines (which act via multiple targets), aiming to enhance treatment efficacy and enhance patient adherence in the management of MS. This concept of combining synthetic and herbal drugs is termed ‘Allo-polyherbal’ and has been shown to improve the efficacy of synthetic drugs and reduction of adverse effects. The present review uncovers the concept of Allo-polyherbal and reveals the potential benefits of using Allopolyherbal in managing diabetes, cardiovascular, hypertension, hyperlipidemia, obesity, and thrombosis leading to MS.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136015157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: Sophora japonica, a species of Sophora, one of the prominent genera, belongs to the family Fabaceae, native to China, which is commonly known as a pagoda tree. Sophora, includes nearly 52 species, nineteen varieties and many of these species have been used in traditional Chinese medicine to cure various ailments. This review compiles its ethnomedical uses, diverse phytochemicals reported from the various parts of S. japonica, and their pharmacological effects to elucidate its therapeutic potential against a wide range of diseases. Traditionally it is used to treat various hematic disorders such as hypertension, hemorrhoids, hemorrhage, hematuria, hematochezia, dysentery, arteriosclerosis, etc. Moreover, each and every part of this plant, including the flowers, buds, leaves, bark, fruits, seeds, pericarp, stems, and roots are used as medicine, particularly in China, Japan, Korea, and Asia. Chinese Pharmacopoeia and European Pharmacopoeia describe the utility of this plant since ancient times. The enhanced use of S. japonica in Chinese medicine resulted in the exploration of various phytochemicals and their pharmacological properties includes in vitro, in vivo, and clinical studies. It is enchanted with steroids, phospholipids, flavonoids, isoflavonoids, alkaloids, triterpenes, and other phenolic compounds that are characterized by therapeutic activities such as anti-oxidant, anticancer, anti-asthmatic, anti-neoplastic, antimicrobial, antiviral, antidote, anti-pyretic, cardiotonic, anti-inflammatory, diuretic, anti-platelet, anti-hyperglycemic, immunomodulatory, anti-diabetic, estrogenic and anti-osteoporotic activity in post-menopausal women etc. and this is also used as a remedy for skin diseases like eczema, colpitis and psoriasis. Despite its health benefits, supplementary data is still required in order to bridge the gaps and ensure the possible safety profile by conducting clinical studies for its therapeutic applications as a natural and eminent safe drug.
{"title":"A Comprehensive Review on Sophora japonica: Ethnomedicinal, Phytochemistry & Pharmacological Aspects","authors":"Srivalli Susmitha Ghatti, Machiraju Garaga, Arnab Chatterjee, Sravani Thimmannagari, Sree Ramya Cherupalli, Nagarajappa Shivaprasad Hebbani, Madhu Krishnamani, Gaurav Soni","doi":"10.2174/0122103155271056230927105208","DOIUrl":"https://doi.org/10.2174/0122103155271056230927105208","url":null,"abstract":"Abstract: Sophora japonica, a species of Sophora, one of the prominent genera, belongs to the family Fabaceae, native to China, which is commonly known as a pagoda tree. Sophora, includes nearly 52 species, nineteen varieties and many of these species have been used in traditional Chinese medicine to cure various ailments. This review compiles its ethnomedical uses, diverse phytochemicals reported from the various parts of S. japonica, and their pharmacological effects to elucidate its therapeutic potential against a wide range of diseases. Traditionally it is used to treat various hematic disorders such as hypertension, hemorrhoids, hemorrhage, hematuria, hematochezia, dysentery, arteriosclerosis, etc. Moreover, each and every part of this plant, including the flowers, buds, leaves, bark, fruits, seeds, pericarp, stems, and roots are used as medicine, particularly in China, Japan, Korea, and Asia. Chinese Pharmacopoeia and European Pharmacopoeia describe the utility of this plant since ancient times. The enhanced use of S. japonica in Chinese medicine resulted in the exploration of various phytochemicals and their pharmacological properties includes in vitro, in vivo, and clinical studies. It is enchanted with steroids, phospholipids, flavonoids, isoflavonoids, alkaloids, triterpenes, and other phenolic compounds that are characterized by therapeutic activities such as anti-oxidant, anticancer, anti-asthmatic, anti-neoplastic, antimicrobial, antiviral, antidote, anti-pyretic, cardiotonic, anti-inflammatory, diuretic, anti-platelet, anti-hyperglycemic, immunomodulatory, anti-diabetic, estrogenic and anti-osteoporotic activity in post-menopausal women etc. and this is also used as a remedy for skin diseases like eczema, colpitis and psoriasis. Despite its health benefits, supplementary data is still required in order to bridge the gaps and ensure the possible safety profile by conducting clinical studies for its therapeutic applications as a natural and eminent safe drug.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136360129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-08DOI: 10.2174/0122103155262670230926120458
Kamran Ansari, Ujjwal Gupta, Antra Sinha, Ankit Sharma, Kalpana Rahate
Osthole is a coumarin derived natural compound which is an essential ingredient of Traditional Chinese Medicine (TMC) which is widely distributed in nature in plants like Cnidium monnieri (L) Cusson and Angelica pubescens. Current study presents a critical review on description of pharmacological importance of osthole, which is reported to exhibit anticancer, antioxidant, osteogenic, hepatoprotective, neuroprotective, cardiovascular protective, antimicrobial, immuno-modulatory and inflammatory activities. Till date, the reports include pharmacological properties, brief chemistry or on advanced methods to explore osthole content in variety of plants. Present review seeks to highlight the sources, biosynthesis, extraction methods, pharmacological properties of the molecule and its derivatives. A brief discussion on patents recently published and granted on the molecule has also been highlighted. Thus the overview of the literature presents the analysis about future possible modalities of the research on this molecule.
{"title":"Osthole: A Medicinally Privileged Natural Compound with its Therapeutic Potential","authors":"Kamran Ansari, Ujjwal Gupta, Antra Sinha, Ankit Sharma, Kalpana Rahate","doi":"10.2174/0122103155262670230926120458","DOIUrl":"https://doi.org/10.2174/0122103155262670230926120458","url":null,"abstract":"Osthole is a coumarin derived natural compound which is an essential ingredient of Traditional Chinese Medicine (TMC) which is widely distributed in nature in plants like Cnidium monnieri (L) Cusson and Angelica pubescens. Current study presents a critical review on description of pharmacological importance of osthole, which is reported to exhibit anticancer, antioxidant, osteogenic, hepatoprotective, neuroprotective, cardiovascular protective, antimicrobial, immuno-modulatory and inflammatory activities. Till date, the reports include pharmacological properties, brief chemistry or on advanced methods to explore osthole content in variety of plants. Present review seeks to highlight the sources, biosynthesis, extraction methods, pharmacological properties of the molecule and its derivatives. A brief discussion on patents recently published and granted on the molecule has also been highlighted. Thus the overview of the literature presents the analysis about future possible modalities of the research on this molecule.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135198114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-05DOI: 10.2174/0122103155251390230927064442
Rui Han, Anand Gaurav, Chun Wai Mai, Vertika Gautam, Akowuah Gabriel Akyirem
Abstract: Phosphodiesterases (PDEs) function to hydrolyze intracellular cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), regulating a variety of intracellular signal transduction and physiological activities. PDEs can be divided into 11 families (PDE1~11) and the diversity and complex expression of PDE family genes suggest that different subtypes may have different mechanisms. PDEs are involved in various disease pathologies such as inflammation, asthma, depression, and erectile dysfunction and are thus targets of interest for several drug discovery campaigns. Natural products have always been an important source of bioactive compounds for drug discovery, over the years several natural compounds have shown potential as inhibitors of PDEs. In this article, phosphodiesterase inhibitors of natural origin have been reviewed with emphasis on their chemistry and biological activities.
{"title":"Phosphodiesterase Inhibitors of Natural Origin","authors":"Rui Han, Anand Gaurav, Chun Wai Mai, Vertika Gautam, Akowuah Gabriel Akyirem","doi":"10.2174/0122103155251390230927064442","DOIUrl":"https://doi.org/10.2174/0122103155251390230927064442","url":null,"abstract":"Abstract: Phosphodiesterases (PDEs) function to hydrolyze intracellular cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), regulating a variety of intracellular signal transduction and physiological activities. PDEs can be divided into 11 families (PDE1~11) and the diversity and complex expression of PDE family genes suggest that different subtypes may have different mechanisms. PDEs are involved in various disease pathologies such as inflammation, asthma, depression, and erectile dysfunction and are thus targets of interest for several drug discovery campaigns. Natural products have always been an important source of bioactive compounds for drug discovery, over the years several natural compounds have shown potential as inhibitors of PDEs. In this article, phosphodiesterase inhibitors of natural origin have been reviewed with emphasis on their chemistry and biological activities.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135546203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.2174/0122103155276658230928094402
Manisha Parthasarathy, Vijayadharsini Seenivasan, Sangeetha Nithiyanandam, Ramkumar Katturajan, Deepak Haraganahalli Bhasakarmurthy, Raja Ganesan, Abilash Valsala Gopalakrishnan, Sheikh F. Ahmad, Sabina Evan Prince
Background:: Methotrexate (MTX) is a widely used medication for treating various conditions, including skin infections, inflammatory diseases, autoimmune disorders, and malignancies. However, prolonged and extreme use of MTX can lead to detrimental effects on multiple organs. Green Chiretta (GC) is a traditional medicinal plant known for its anti-inflammatory, antioxidant, and immunostimulatory properties. Objective:: The objective of this study is to examine the antioxidant potential of GC through in-vitro analysis and to assess the potential protective effects of aqueous leaf extracts of GC against MTXinduced cardiac and spleen toxicity. Methods:: In-vitro antioxidant activity was assessed by measuring total phenolic content, DPPH, catalase and peroxidase activity. We divided rats into five groups (n=6), and after the study, rats were euthanized and the levels of antioxidants (SOD, CAT & GSH) and lipid peroxidase (MDA), as well as histopathology modification of the heart and spleen tissues were examined. Results:: Our study's findings highlight the superiority of the aqueous GC extract's antioxidant capacity relative to other solvents (ethanol and methanol). Moreover, the aqueous GC extract's administration to rats yielded significant progress in antioxidant levels (Superoxide dismutase, catalase, glutathione), a reduction in lipid peroxidation (MDA), and the restoration of cardiac and spleen histoarchitecture against MTX-induced toxicity. These results collectively emphasize the extract's potential as a valuable therapeutic option against oxidative stress and tissue damage. Conclusion:: The present study revealed that the aqueous GC extract demonstrated its protective efficacy against MTX-induced cardio and spleen toxicity in Wistar albino rats conclusion: The present study revealed that the aqueous GC extract demonstrated its protective efficacy against MTX-induced cardio and spleen toxicity in Wistar albino rats.
{"title":"Protective Effect of Green Chiretta (Andrographis paniculata) against Methotrexate-induced Cardio and Spleen Toxicity: In-vitro and In-vivo","authors":"Manisha Parthasarathy, Vijayadharsini Seenivasan, Sangeetha Nithiyanandam, Ramkumar Katturajan, Deepak Haraganahalli Bhasakarmurthy, Raja Ganesan, Abilash Valsala Gopalakrishnan, Sheikh F. Ahmad, Sabina Evan Prince","doi":"10.2174/0122103155276658230928094402","DOIUrl":"https://doi.org/10.2174/0122103155276658230928094402","url":null,"abstract":"Background:: Methotrexate (MTX) is a widely used medication for treating various conditions, including skin infections, inflammatory diseases, autoimmune disorders, and malignancies. However, prolonged and extreme use of MTX can lead to detrimental effects on multiple organs. Green Chiretta (GC) is a traditional medicinal plant known for its anti-inflammatory, antioxidant, and immunostimulatory properties. Objective:: The objective of this study is to examine the antioxidant potential of GC through in-vitro analysis and to assess the potential protective effects of aqueous leaf extracts of GC against MTXinduced cardiac and spleen toxicity. Methods:: In-vitro antioxidant activity was assessed by measuring total phenolic content, DPPH, catalase and peroxidase activity. We divided rats into five groups (n=6), and after the study, rats were euthanized and the levels of antioxidants (SOD, CAT & GSH) and lipid peroxidase (MDA), as well as histopathology modification of the heart and spleen tissues were examined. Results:: Our study's findings highlight the superiority of the aqueous GC extract's antioxidant capacity relative to other solvents (ethanol and methanol). Moreover, the aqueous GC extract's administration to rats yielded significant progress in antioxidant levels (Superoxide dismutase, catalase, glutathione), a reduction in lipid peroxidation (MDA), and the restoration of cardiac and spleen histoarchitecture against MTX-induced toxicity. These results collectively emphasize the extract's potential as a valuable therapeutic option against oxidative stress and tissue damage. Conclusion:: The present study revealed that the aqueous GC extract demonstrated its protective efficacy against MTX-induced cardio and spleen toxicity in Wistar albino rats conclusion: The present study revealed that the aqueous GC extract demonstrated its protective efficacy against MTX-induced cardio and spleen toxicity in Wistar albino rats.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135647356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-04DOI: 10.2174/0122103155273860230928071249
Sonia Singh, Arpit Shukla
Abstract: Piperine, an alkaloid from black pepper, has demonstrated diverse pharmacological properties and potential therapeutic applications. Piperine content varies with the pepper plant and ranges from 2 to 7.4% in black pepper. Piperine possesses remarkable biological properties, including antioxidant, anti-inflammatory, antibacterial, anticancer, neuroprotective, and hepatoprotective qualities. Its ability to affect numerous signaling pathways and biological targets implicated in disease development is responsible for these functions. Studies have shown piperine to have high antioxidant activity, which aids in reducing oxidative stress and preventing cellular damage. It has been established that its anti-inflammatory effects suppress the generation of pro-inflammatory mediators, thereby relieving inflammation-related diseases. This review emphasizes and examines piperine's medical and health-promoting benefits and proposed mechanisms of action in health promotion and illness prevention.
{"title":"Therapeutic Potential of Piperine: A Comprehensive Review","authors":"Sonia Singh, Arpit Shukla","doi":"10.2174/0122103155273860230928071249","DOIUrl":"https://doi.org/10.2174/0122103155273860230928071249","url":null,"abstract":"Abstract: Piperine, an alkaloid from black pepper, has demonstrated diverse pharmacological properties and potential therapeutic applications. Piperine content varies with the pepper plant and ranges from 2 to 7.4% in black pepper. Piperine possesses remarkable biological properties, including antioxidant, anti-inflammatory, antibacterial, anticancer, neuroprotective, and hepatoprotective qualities. Its ability to affect numerous signaling pathways and biological targets implicated in disease development is responsible for these functions. Studies have shown piperine to have high antioxidant activity, which aids in reducing oxidative stress and preventing cellular damage. It has been established that its anti-inflammatory effects suppress the generation of pro-inflammatory mediators, thereby relieving inflammation-related diseases. This review emphasizes and examines piperine's medical and health-promoting benefits and proposed mechanisms of action in health promotion and illness prevention.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135647378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.2174/0122103155274328230926160728
Danmei Tian, Mei Chen, Wenjuan Ding, Jia Li, Shi Wu, Kui Hong, Jinshan Tang
Background: Marine fungi have been proven to be a new arsenal for the discovery of valuable secondary metabolites. background: Marine fungi have been proved to be new arsenal for discovery of valuable secondary metabolites. The discovery of new bioactive secondary metabolites from Aspergillus sp. still possesses vast potential. Method:: Here, a new cinnamate derivative, plicatin C (1), together with 18 known compounds, was isolated from the solid and liquid state fermentations of a mangrove-derived fungus Aspergillus terreus DM62. Their chemical structures were elucidated by extensive spectroscopic analyses and optical rotations. Subsequently, the α-glucosidase inhibitory activity of isolated compounds was assessed to investigate their hypoglycemic activity Result:: Results showed that compounds 3, 6, and 8-10 exhibited stronger α-glucosidase inhibitory activities than acarbose at 400 μM. Meanwhile, ATP-citrate lyase (ACL) inhibitory activity of the isolated compounds was evaluated, and butenolide 3, with an IC50 value of 21.5 μM, was discovered with significant ACL inhibitory activity for the first time. Conclusion:: This study not only discovered a new cinnamate derivative but also found butenolides with potent ACL inhibitory activity, which is favorable to clarify their pharmacological mechanism in the treatment of metabolic disease.
{"title":"Plicatin C: A New Cinnamate Derivative from Mangrove-derived Fungus Aspergillus terreus DM62","authors":"Danmei Tian, Mei Chen, Wenjuan Ding, Jia Li, Shi Wu, Kui Hong, Jinshan Tang","doi":"10.2174/0122103155274328230926160728","DOIUrl":"https://doi.org/10.2174/0122103155274328230926160728","url":null,"abstract":"Background: Marine fungi have been proven to be a new arsenal for the discovery of valuable secondary metabolites. background: Marine fungi have been proved to be new arsenal for discovery of valuable secondary metabolites. The discovery of new bioactive secondary metabolites from Aspergillus sp. still possesses vast potential. Method:: Here, a new cinnamate derivative, plicatin C (1), together with 18 known compounds, was isolated from the solid and liquid state fermentations of a mangrove-derived fungus Aspergillus terreus DM62. Their chemical structures were elucidated by extensive spectroscopic analyses and optical rotations. Subsequently, the α-glucosidase inhibitory activity of isolated compounds was assessed to investigate their hypoglycemic activity Result:: Results showed that compounds 3, 6, and 8-10 exhibited stronger α-glucosidase inhibitory activities than acarbose at 400 μM. Meanwhile, ATP-citrate lyase (ACL) inhibitory activity of the isolated compounds was evaluated, and butenolide 3, with an IC50 value of 21.5 μM, was discovered with significant ACL inhibitory activity for the first time. Conclusion:: This study not only discovered a new cinnamate derivative but also found butenolides with potent ACL inhibitory activity, which is favorable to clarify their pharmacological mechanism in the treatment of metabolic disease.","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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