Pub Date : 2022-12-08DOI: 10.2174/2210315513666221208154957
B. P. Kamdem, Eutrophe Le Doux Kamto, Désiré Soh, D. E. Pegnyemb, Stéphane Zingué, H. K. Paumo, L. Katata-Seru, Aboubakar Abou, Montsho Maiyane Rosinah, J. Mbah, F. Boyom
Native to the Southern Mediterranean region, Laurus nobilis L. (Family Lauraceae) is an evergreen shrub or tree found in warm climate regions with high rainfall. The leaves and essential oil of this plant have been widely used as condiments, spices, and flavoring agents in the culinary and food industries. The whole plant is also used for the traditional treatment of various diseases, including cough, asthma, hemorrhoids, rheumatic pain, diarrhea, intestinal, and cardiac diseases. Previous phytochemical investigation of this plant demonstrated the presence of a variety of secondary metabolites, especially terpenoids. The present study aims to critically analyze comprehensive literature on the pharmacological activity and mechanisms of action of terpenoids from Laurus nobilis L. The available information on the pharmacological activity of terpenoids from L. nobilis L. was obtained from textbooks, theses, as well as published articles through a variety of libraries and electronic databases. The present study demonstrated that L. nobilis is rich in terpenoids, with more than 200 entities identified in reported studies. Terpenoids from L. nobilis have shown a wide range of pharmacological activities, including anti-inflammatory, antidiabetic, antifungal, antibacterial, immunomodulatory, anticonvulsant, antioxidant and cytotoxic activities. The mechanisms of action of most of these terpenoids included the imbalance of the ionic permeability of the cell membrane (anti-inflammatory and antimicrobial activities), modulation of the effects of gamma-aminobutyric acid (GABA)nergic neurotransmission (anticonvulsant activity), and the inhibition of inflammatory responses, prevention of metastasis, and induction of apoptosis (cytotoxic effect), among others. Referring to in vitro studies, terpenoids of L. nobilis L. have shown a variety of biological activities. However, more cytotoxic and in vivo studies and detailed mechanisms of action of the bioactive terpenoids are recommended.
Laurus nobilis L.（樟科）原产于地中海南部地区，是一种常绿灌木或树木，分布在气候温暖、降雨量大的地区。这种植物的叶子和精油在烹饪和食品工业中被广泛用作调味品、香料和调味剂。整株植物还用于各种疾病的传统治疗，包括咳嗽、哮喘、痔疮、风湿性疼痛、腹泻、肠道和心脏病。先前对该植物的植物化学研究表明，该植物存在多种次生代谢产物，尤其是萜类化合物。本研究旨在批判性地分析关于月桂萜类化合物药理活性和作用机制的综合文献。有关月桂萜类物质药理活性的现有信息来自教科书、论文以及通过各种图书馆和电子数据库发表的文章。本研究表明，锦葵富含萜类化合物，在已报道的研究中鉴定了200多个实体。诺比尔乳杆菌的萜类化合物具有广泛的药理活性，包括抗炎、抗糖尿病、抗真菌、抗菌、免疫调节、抗惊厥、抗氧化和细胞毒性活性。这些萜类化合物的作用机制包括细胞膜离子渗透性的失衡（抗炎和抗菌活性）、调节γ-氨基丁酸（GABA）能神经传递的作用（抗惊厥活性）以及抑制炎症反应、预防转移、，以及诱导细胞凋亡（细胞毒性作用）等。根据体外研究，锦葵的萜类化合物显示出多种生物活性。然而，建议对生物活性萜类化合物进行更多的细胞毒性和体内研究以及详细的作用机制。
{"title":"Pharmacological activity and mechanisms of action of terpenoids from Laurus nobilis L","authors":"B. P. Kamdem, Eutrophe Le Doux Kamto, Désiré Soh, D. E. Pegnyemb, Stéphane Zingué, H. K. Paumo, L. Katata-Seru, Aboubakar Abou, Montsho Maiyane Rosinah, J. Mbah, F. Boyom","doi":"10.2174/2210315513666221208154957","DOIUrl":"https://doi.org/10.2174/2210315513666221208154957","url":null,"abstract":"\u0000\u0000Native to the Southern Mediterranean region, Laurus nobilis L. (Family Lauraceae) is an evergreen shrub or tree found in warm climate regions with high rainfall. The leaves and essential oil of this plant have been widely used as condiments, spices, and flavoring agents in the culinary and food industries. The whole plant is also used for the traditional treatment of various diseases, including cough, asthma, hemorrhoids, rheumatic pain, diarrhea, intestinal, and cardiac diseases. Previous phytochemical investigation of this plant demonstrated the presence of a variety of secondary metabolites, especially terpenoids.\u0000\u0000\u0000\u0000The present study aims to critically analyze comprehensive literature on the pharmacological activity and mechanisms of action of terpenoids from Laurus nobilis L.\u0000\u0000\u0000\u0000The available information on the pharmacological activity of terpenoids from L. nobilis L. was obtained from textbooks, theses, as well as published articles through a variety of libraries and electronic databases.\u0000\u0000\u0000\u0000The present study demonstrated that L. nobilis is rich in terpenoids, with more than 200 entities identified in reported studies. Terpenoids from L. nobilis have shown a wide range of pharmacological activities, including anti-inflammatory, antidiabetic, antifungal, antibacterial, immunomodulatory, anticonvulsant, antioxidant and cytotoxic activities. The mechanisms of action of most of these terpenoids included the imbalance of the ionic permeability of the cell membrane (anti-inflammatory and antimicrobial activities), modulation of the effects of gamma-aminobutyric acid (GABA)nergic neurotransmission (anticonvulsant activity), and the inhibition of inflammatory responses, prevention of metastasis, and induction of apoptosis (cytotoxic effect), among others.\u0000\u0000\u0000\u0000Referring to in vitro studies, terpenoids of L. nobilis L. have shown a variety of biological activities. However, more cytotoxic and in vivo studies and detailed mechanisms of action of the bioactive terpenoids are recommended.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44453924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-25DOI: 10.2174/2210315513666221125142944
Huseyin Aksit, Erdem Ozan, R. Erenler
Natural products have been used commonly in the pharmaceutical industry as well as traditional medicine due to their bioactive contents. The objective of this study is to isolate the polymethoxy flavones (PMFs) and evaluate the antiproliferative activity. The PMFs were extracted from Mentha dumetorum with boiling hot water and then partitioned with hexane and the extract was subjected to chromatographic techniques such as Sephadex LH-20, silica gel, and preparative TLC, and HPLC to isolate the compounds. The structures of isolated compounds were elucidated by spectroscopic techniques such as 1H-NMR, 13C-NMR, LC-TOF-MS, and UV-Vis. The anti-cancer effects of isolated compounds were evaluated using a real-time cell analyzer–single plate (RTCA-SP) instrument against HeLa and HT29 cell lines. The isolated PMFs were identified as xanthomicrol (1), 5-hydroxy-6,7,8,4'-tetrametoxy flavanone (2), 5-desmetil sinensetin (3), 5-demetil nobiletin (4), gardenin B (5), 5-hydroxy-6,7,8,3',4'-penta methoxy flavanone (6) and 5-hydroxy-6,7,4'-trimethoxy flavone (7). Compounds 2 and 5 were found to be the most active against both cell lines. The isolated compounds as well as the plant extract of Mentha dumetorum could be promising agents for the drug development process, especially drugs for cancer treatment. Moreover, isolation methods were developed for the corresponding compounds.
{"title":"Isolation, characterization, and antiproliferative activity of polymethoxy flavones from Mentha dumetorum","authors":"Huseyin Aksit, Erdem Ozan, R. Erenler","doi":"10.2174/2210315513666221125142944","DOIUrl":"https://doi.org/10.2174/2210315513666221125142944","url":null,"abstract":"\u0000\u0000Natural products have been used commonly in the pharmaceutical industry as well as traditional medicine due to their bioactive contents.\u0000\u0000\u0000\u0000The objective of this study is to isolate the polymethoxy flavones (PMFs) and evaluate the antiproliferative activity.\u0000\u0000\u0000\u0000The PMFs were extracted from Mentha dumetorum with boiling hot water and then partitioned with hexane and the extract was subjected to chromatographic techniques such as Sephadex LH-20, silica gel, and preparative TLC, and HPLC to isolate the compounds. The structures of isolated compounds were elucidated by spectroscopic techniques such as 1H-NMR, 13C-NMR, LC-TOF-MS, and UV-Vis. The anti-cancer effects of isolated compounds were evaluated using a real-time cell analyzer–single plate (RTCA-SP) instrument against HeLa and HT29 cell lines.\u0000\u0000\u0000\u0000The isolated PMFs were identified as xanthomicrol (1), 5-hydroxy-6,7,8,4'-tetrametoxy flavanone (2), 5-desmetil sinensetin (3), 5-demetil nobiletin (4), gardenin B (5), 5-hydroxy-6,7,8,3',4'-penta methoxy flavanone (6) and 5-hydroxy-6,7,4'-trimethoxy flavone (7). Compounds 2 and 5 were found to be the most active against both cell lines.\u0000\u0000\u0000\u0000The isolated compounds as well as the plant extract of Mentha dumetorum could be promising agents for the drug development process, especially drugs for cancer treatment. Moreover, isolation methods were developed for the corresponding compounds.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47107438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-14DOI: 10.2174/2210315513666221114112253
S. Abu Bakar, K. Chin, N. Zainal, S. Sam
Zika virus (ZIKV) infection is a public health concern and currently there is no specific therapeutic or approved vaccine. Resveratrol (RESV), a natural antiviral compound, has been shown to possess antiviral properties against ZIKV and other viral infections, but the mechanisms of action against ZIKV remain unknown. This study aimed to investigate the role of the high mobility group box 1 protein (HMGB1) in the underlying anti-ZIKV mechanisms of RESV. HMGB1 protein expression and ZIKV replication in both the RESV-treated wild-type (WT) and HMGB1-knockdown (shHMGB1) Huh7 cells were analyzed using ELISA, immunofluorescence assay, immunoblot assay, focus-forming assay and qRT-PCR. HMGB1’s role was explored by evaluating the changes in the type-1 interferon (IFN) response genes using the qRT-PCR and immunoblot assays. The treatment of the ZIKV-infected WT Huh7 cells with RESV significantly reduced ZIKV titers by >90% (P < 0.001) at 48 and 72 hr pi in a dose-dependent manner and inhibited ZIKV-induced HMGB1 translocation (P < 0.001), resulting in nuclear HMGB1 accumulation. Compared to the WT Huh7 cells and shHMGB1 Huh7 cells without RESV treatment showed a significant increase in the infectious virus titers and RNA with a maximum rise of 74% (P < 0.001) and 65% (P < 0.01), respectively. RESV treatment of the ZIKV-infected WT Huh7 cells significantly increased the MxA (one of the classical interferon-stimulated genes, ISGs) and IFN-β levels (p < 0.05). The treatment of the infected shHMGB1 Huh7 cells with RESV showed a less effective antiviral response (P > 0.05) and did not cause changes in the expressions of MxA and IFN-β. RESV possesses therapeutic activity against ZIKV infection and the mechanism of action is mainly attributed to HMGB1 nuclear retention, which could upregulate the type-1 IFN and ISGs. -
{"title":"Resveratrol treatment-induced nuclear HMGB1 retention is critical for inducing host interferon responses against Zika virus","authors":"S. Abu Bakar, K. Chin, N. Zainal, S. Sam","doi":"10.2174/2210315513666221114112253","DOIUrl":"https://doi.org/10.2174/2210315513666221114112253","url":null,"abstract":"\u0000\u0000Zika virus (ZIKV) infection is a public health concern and currently there is no specific therapeutic or approved vaccine. Resveratrol (RESV), a natural antiviral compound, has been shown to possess antiviral properties against ZIKV and other viral infections, but the mechanisms of action against ZIKV remain unknown.\u0000\u0000\u0000\u0000This study aimed to investigate the role of the high mobility group box 1 protein (HMGB1) in the underlying anti-ZIKV mechanisms of RESV.\u0000\u0000\u0000\u0000HMGB1 protein expression and ZIKV replication in both the RESV-treated wild-type (WT) and HMGB1-knockdown (shHMGB1) Huh7 cells were analyzed using ELISA, immunofluorescence assay, immunoblot assay, focus-forming assay and qRT-PCR. HMGB1’s role was explored by evaluating the changes in the type-1 interferon (IFN) response genes using the qRT-PCR and immunoblot assays.\u0000\u0000\u0000\u0000The treatment of the ZIKV-infected WT Huh7 cells with RESV significantly reduced ZIKV titers by >90% (P < 0.001) at 48 and 72 hr pi in a dose-dependent manner and inhibited ZIKV-induced HMGB1 translocation (P < 0.001), resulting in nuclear HMGB1 accumulation. Compared to the WT Huh7 cells and shHMGB1 Huh7 cells without RESV treatment showed a significant increase in the infectious virus titers and RNA with a maximum rise of 74% (P < 0.001) and 65% (P < 0.01), respectively. RESV treatment of the ZIKV-infected WT Huh7 cells significantly increased the MxA (one of the classical interferon-stimulated genes, ISGs) and IFN-β levels (p < 0.05). The treatment of the infected shHMGB1 Huh7 cells with RESV showed a less effective antiviral response (P > 0.05) and did not cause changes in the expressions of MxA and IFN-β.\u0000\u0000\u0000\u0000RESV possesses therapeutic activity against ZIKV infection and the mechanism of action is mainly attributed to HMGB1 nuclear retention, which could upregulate the type-1 IFN and ISGs.\u0000\u0000\u0000\u0000-\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45213581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-04DOI: 10.2174/2210315513666221104154116
Han-Seung Shin, Yong-Yeon Kim
Sandwich enzyme-linked immunosorbent assay (ELISA) to quantify monoclonal antibody (B[a]P-13) Only a few studies have focused on the analysis using specific antibodies in the sandwich ELISA method to each B[a]P in herbal medicine products. In contrast to the sandwich ELISA method, many competitive ELISA methods using specific antibodies such as benzo[a]pyrene monoclonal antibody (B[a]P-13) and a goat anti-mouse IgG (H+L) cross-adsorbed secondary antibody, horseradish peroxidase (HRP) were developed. The objective of this study was to develop and validate the method for the response of the benzo[a]pyrene monoclonal antibody (B[a]P-13) and goat anti-mouse IgG (H+L) cross-adsorbed secondary antibody (HRP) to prepare the immunogen and its application to detect the benzo[a]pyrene in various herbal medicine products. This research method includes preparation of B[a]P-protein conjugates, sampling and extraction procedure for herbal medicines, sandwich ELISA procedure, evaluation of cross-reactivity for determination, matrix effect of the organic solvents, correlation of benzo[a]pyrene detection ELISA compared to HPLC-FLD in herbal medicine products. The sandwich ELISA method for B[a]P was validated in linearity (R2 > 0.99), the limit of detection (LOD) (0.080.19 μg/kg) and limit of quantification (LOQ) (0.240.57 μg/kg), accuracy (95.58117.06 %), and precision (3.8010.26 %). The cross-reactivity (CR) was found for B[a]P (100%), CHR (39%), B[b]F (27%), and B[a]A (41%). As a solvent, acetonitrile (MeCN) was used to express the normalized sandwich ELISA calibration curves with benzo[a]pyrene monoclonal antibody (B[a]P-13). The antigen-antibody binding in sandwich ELISA was decreased about 10 times with increasing the salt content (0.0060.18 mol/L phosphate to 20400 mmol/L). The pH range from 6 to 9 was not considered to affect the performance of the sandwich ELISA. Correlation of B[a]P detection in herbal medicines with ELISA compared to HPLC-FLD expressed good correlation (R2 = 0.991) and the slope of the graph for the ELISA (B[a]P-equivalents μg/kg) value divided by the HPLC-FLD (B[a]P μg/kg) value was 0.7292. Therefore, sandwich ELISA method using benzo[a]pyrene monoclonal antibody (B[a]P-13) could be an alternative screening method for detection of B[a]P in herbal medicine products.
{"title":"Sandwich enzyme-linked immunosorbent assay (ELISA) to quantify monoclonal antibody (B[a]P-13) for herbal medicine products","authors":"Han-Seung Shin, Yong-Yeon Kim","doi":"10.2174/2210315513666221104154116","DOIUrl":"https://doi.org/10.2174/2210315513666221104154116","url":null,"abstract":"\u0000\u0000Sandwich enzyme-linked immunosorbent assay (ELISA) to quantify monoclonal antibody (B[a]P-13)\u0000\u0000\u0000\u0000Only a few studies have focused on the analysis using specific antibodies in the sandwich ELISA method to each B[a]P in herbal medicine products. In contrast to the sandwich ELISA method, many competitive ELISA methods using specific antibodies such as benzo[a]pyrene monoclonal antibody (B[a]P-13) and a goat anti-mouse IgG (H+L) cross-adsorbed secondary antibody, horseradish peroxidase (HRP) were developed.\u0000\u0000\u0000\u0000The objective of this study was to develop and validate the method for the response of the benzo[a]pyrene monoclonal antibody (B[a]P-13) and goat anti-mouse IgG (H+L) cross-adsorbed secondary antibody (HRP) to prepare the immunogen and its application to detect the benzo[a]pyrene in various herbal medicine products.\u0000\u0000\u0000\u0000This research method includes preparation of B[a]P-protein conjugates, sampling and extraction procedure for herbal medicines, sandwich ELISA procedure, evaluation of cross-reactivity for determination, matrix effect of the organic solvents, correlation of benzo[a]pyrene detection ELISA compared to HPLC-FLD in herbal medicine products.\u0000\u0000\u0000\u0000The sandwich ELISA method for B[a]P was validated in linearity (R2 > 0.99), the limit of detection (LOD) (0.080.19 μg/kg) and limit of quantification (LOQ) (0.240.57 μg/kg), accuracy (95.58117.06 %), and precision (3.8010.26 %). The cross-reactivity (CR) was found for B[a]P (100%), CHR (39%), B[b]F (27%), and B[a]A (41%). As a solvent, acetonitrile (MeCN) was used to express the normalized sandwich ELISA calibration curves with benzo[a]pyrene monoclonal antibody (B[a]P-13). The antigen-antibody binding in sandwich ELISA was decreased about 10 times with increasing the salt content (0.0060.18 mol/L phosphate to 20400 mmol/L). The pH range from 6 to 9 was not considered to affect the performance of the sandwich ELISA. Correlation of B[a]P detection in herbal medicines with ELISA compared to HPLC-FLD expressed good correlation (R2 = 0.991) and the slope of the graph for the ELISA (B[a]P-equivalents μg/kg) value divided by the HPLC-FLD (B[a]P μg/kg) value was 0.7292.\u0000\u0000\u0000\u0000Therefore, sandwich ELISA method using benzo[a]pyrene monoclonal antibody (B[a]P-13) could be an alternative screening method for detection of B[a]P in herbal medicine products.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44422067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-12DOI: 10.2174/2210315513666221012102746
Akanksha Pandey, P. Sharma, R. Malviya, K. Rahate
Pectins are polysaccharides that have a sequence that is similar to that of plant cell membranes that are predominantly made up of galacturonic acid units, and their concentration, morphology, and molecular mass vary. Tissue engineering is a multidisciplinary field that examines natural replacement for the injured tissue to heal or preserve its function and it involves the use of scaffolds, cells, and biomolecules. Biocompatible, biodegradable, and permeable scaffolds are required. The goal of the study is to find the potential of pectin/pectin derivative scaffolds for tissue engineering applications.
{"title":"Pectin/ Pectin Derivatives as Potential Scaffolds for the Tissue Engineering Applications","authors":"Akanksha Pandey, P. Sharma, R. Malviya, K. Rahate","doi":"10.2174/2210315513666221012102746","DOIUrl":"https://doi.org/10.2174/2210315513666221012102746","url":null,"abstract":"\u0000\u0000Pectins are polysaccharides that have a sequence that is similar to that of plant cell membranes that are predominantly made up of galacturonic acid units, and their concentration, morphology, and molecular mass vary. Tissue engineering is a multidisciplinary field that examines natural replacement for the injured tissue to heal or preserve its function and it involves the use of scaffolds, cells, and biomolecules. Biocompatible, biodegradable, and permeable scaffolds are required. The goal of the study is to find the potential of pectin/pectin derivative scaffolds for tissue engineering applications.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47567401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-05DOI: 10.2174/2210315513666221005093047
Mahdi Barazesh, Morteza Akhzari, S. Mohammadi, S. Jalili, Karim Noorizadeh
Nigella sativa L. (Ranunculaceae) is one of the most widely used traditional therapeutic plants. It possesses important classes of bioactive compounds among which thymoquinone as the major bioactive component of the essential oil has attracted noteworthy attention due to its active role in treating a various range of disorders. N. sativa can induce a wide range of pharmacological functions including anti-oxidative stress responses, antidiabetic, anticancer, cell apoptosis and increase membrane permeability, immunomodulatory, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilatory, hepato-protective, renal protective, gastro-protective, and antioxidant properties. The seeds of N. sativa , commonly known as black seed or black cumin, show many potential pharmacological roles and are utilized in folk (herbal) medicine all over the world for the treatment and prevention of a various range of diseases and conditions including asthma, cancers, inflammatory situations, type 2 diabetes mellitus disorders, bacterial and viral infections, and dyslipidemia. This review outlines the main pharmacological properties of N. sativa and its components due to their potential wide applications for a large variety of human diseases. The seeds constitute both fixed and essential oils, proteins, alkaloids and saponin. Much of the biological function of the seeds has been demonstrated to be due to thymoquinone. Beneficial influences of the seeds application and thymoquinone might be contributed to their cytoprotective and antioxidant functions, and to their effect on immune response and some inflammatory mediators.
{"title":"Nigella sativa, a Jack of all trades plant in medicine: Pharmacological aspects in diseases treatment and prevention","authors":"Mahdi Barazesh, Morteza Akhzari, S. Mohammadi, S. Jalili, Karim Noorizadeh","doi":"10.2174/2210315513666221005093047","DOIUrl":"https://doi.org/10.2174/2210315513666221005093047","url":null,"abstract":"\u0000\u0000Nigella sativa L. (Ranunculaceae) is one of the most widely used traditional therapeutic plants. It possesses important classes of bioactive compounds among which thymoquinone as the major bioactive component of the essential oil has attracted noteworthy attention due to its active role in treating a various range of disorders. N. sativa can induce a wide range of pharmacological\u0000functions including anti-oxidative stress responses, antidiabetic, anticancer, cell apoptosis and increase membrane permeability, immunomodulatory, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilatory, hepato-protective, renal protective, gastro-protective, and antioxidant properties. The seeds of N. sativa , commonly known as black seed or black cumin, show many potential pharmacological roles and are utilized in folk (herbal) medicine all over the world for the treatment and prevention of a various range of diseases and conditions including asthma, cancers, inflammatory situations, type 2 diabetes mellitus disorders, bacterial and viral infections, and dyslipidemia. This review outlines the main pharmacological properties of N. sativa and its components due to their potential wide applications for a large variety of human diseases. The seeds constitute both fixed and essential oils, proteins, alkaloids and saponin. Much of the biological function of the seeds has been demonstrated to be due to thymoquinone. Beneficial influences of the seeds application and thymoquinone might be contributed to their cytoprotective and antioxidant functions, and to their effect on immune response and some inflammatory mediators.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42316159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-03DOI: 10.2174/2210315513666221003120940
L. Payahoo, S. Ebrahimpour-Koujan, Y. Khajebishak, Kamran Roudini, Nima Baziar, Samaneh Shabani
Glioblastoma multiform (GBM) is a malignant subgroup of gliomas. Due to the natural resistance of GBM cells to radio-and chemotherapy usually, recurrence occurs 6-9 months after diagnosis. This paper reviewed the beneficial effects of Boswellic acid (BA) in adjacent therapy for GBM, based on its possible molecular mechanisms. In this review paper, all papers indexed in scientific databases, including PubMed, Scopus, Embase, Google Scholar, and Elsevier were searched during 2000 - 2021 using apoptosis, Boswellic acid, cancer, glioblastoma multiform, inflammation, oxidative stress as keywords. The most important compounds of BAs are alpha-boswellic acid, beta- boswellic acid, acetyl-beta- boswellic acid, acetyl-alpha- boswellic acid, and 11-keto-beta- boswellic acid (KBA). Anti-inflammation, reduction of the skin irritation, anti-tumor, anti-cancer, anxiolytic, and anti-phlogistic, are defined as the main properties of BAs. Boswellic acid is recognized as a chemopreventive agent. Boswellic acid exerts its effects mainly via various mechanisms such as induction of apoptosis and cytotoxic effects on malignant cells, activation of caspases, up-regulation of genes expression with potential anti-apoptotic and pro-survival properties, inhibition the signaling and activity pathway of nuclear factor-kappa B (NF-κB) and enhancing poly (ADP)-ribose polymerase (PARP) cleavage. Boswellic acid inhibits the signaling pathway of 5 and 12-lipoxygenase (5, 12 LOX), and cyclooxygenase-2 (COX-2) which are considered triggers in the production of inflammatory cytokines such as tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β). Future clinical trials are needed to identify the interaction between Boswellic acid and the severity of GBM and to define the safe dose and effective duration of supplementation.
{"title":"Chemotherapeutic effects of Boswellic Acid against human glioblastoma multiform: A comprehensive review","authors":"L. Payahoo, S. Ebrahimpour-Koujan, Y. Khajebishak, Kamran Roudini, Nima Baziar, Samaneh Shabani","doi":"10.2174/2210315513666221003120940","DOIUrl":"https://doi.org/10.2174/2210315513666221003120940","url":null,"abstract":"\u0000\u0000Glioblastoma multiform (GBM) is a malignant subgroup of gliomas. Due to the natural resistance of GBM cells to radio-and chemotherapy usually, recurrence occurs 6-9 months after diagnosis. This paper reviewed the beneficial effects of Boswellic acid (BA) in adjacent therapy for GBM, based on its possible molecular mechanisms.\u0000\u0000\u0000\u0000In this review paper, all papers indexed in scientific databases, including PubMed, Scopus, Embase, Google Scholar, and Elsevier were searched during 2000 - 2021 using apoptosis, Boswellic acid, cancer, glioblastoma multiform, inflammation, oxidative stress as keywords.\u0000\u0000\u0000\u0000The most important compounds of BAs are alpha-boswellic acid, beta- boswellic acid, acetyl-beta- boswellic acid, acetyl-alpha- boswellic acid, and 11-keto-beta- boswellic acid (KBA). Anti-inflammation, reduction of the skin irritation, anti-tumor, anti-cancer, anxiolytic, and anti-phlogistic, are defined as the main properties of BAs. Boswellic acid is recognized as a chemopreventive agent. Boswellic acid exerts its effects mainly via various mechanisms such as induction of apoptosis and cytotoxic effects on malignant cells, activation of caspases, up-regulation of genes expression with potential anti-apoptotic and pro-survival properties, inhibition the signaling and activity pathway of nuclear factor-kappa B (NF-κB) and enhancing poly (ADP)-ribose polymerase (PARP) cleavage. Boswellic acid inhibits the signaling pathway of 5 and 12-lipoxygenase (5, 12 LOX), and cyclooxygenase-2 (COX-2) which are considered triggers in the production of inflammatory cytokines such as tumor necrosis factor (TNF-α), and interleukin-1β (IL-1β).\u0000\u0000\u0000\u0000Future clinical trials are needed to identify the interaction between Boswellic acid and the severity of GBM and to define the safe dose and effective duration of supplementation.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47658123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-28DOI: 10.2174/2210315513666220928112238
Yen Yen Sally Rahayu
Due to its accuracy and expert-authenticated validation mechanism, DNA barcoding technology is advocated to be superior to existing methods of species identification. While DNA barcoding is generally viewed as valuable innovation in herbal materials authentication, the acceptability and accessibility issues pose a barrier to its uptake into the global herbal regulatory framework. We explore the current status of DNA barcoding technology for quality assurance of herbal materials/products (HM/P) and the challenges of its formal adoption into multi-level policy. We discuss the adulteration problem in the HM/P value chain, an overview of DNA barcoding technology features, and the current use of DNA barcoding from the perspective of four key stakeholders—epistemic group, international bodies, governments, and market agents—practice DNA barcoding technology in the HM/P value chain. The discussion also includes the status of DNA barcoding in the control system of HM/P in the US, EU, and China and some recommendations on how the application of DNA barcoding as quality control/assurance can be deployed in the HM/P value chain.
{"title":"Assessing Adoption of DNA Barcoding in Herbal Value Chain: A Multi-stakeholder Analysis","authors":"Yen Yen Sally Rahayu","doi":"10.2174/2210315513666220928112238","DOIUrl":"https://doi.org/10.2174/2210315513666220928112238","url":null,"abstract":"\u0000\u0000Due to its accuracy and expert-authenticated validation mechanism, DNA barcoding technology is advocated to be superior to existing methods of species identification. While DNA barcoding is generally viewed as valuable innovation in herbal materials authentication, the acceptability and accessibility issues pose a barrier to its uptake into the global herbal regulatory framework. We explore the current status of DNA barcoding technology for quality assurance of herbal materials/products (HM/P) and the challenges of its formal adoption into multi-level policy. We discuss the adulteration problem in the HM/P value chain, an overview of DNA barcoding technology features, and the current use of DNA barcoding from the perspective of four key stakeholders—epistemic group, international bodies, governments, and market agents—practice DNA barcoding technology in the HM/P value chain. The discussion also includes the status of DNA barcoding in the control system of HM/P in the US, EU, and China and some recommendations on how the application of DNA barcoding as quality control/assurance can be deployed in the HM/P value chain.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44988369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.2174/2210315512666220907150542
V. Narala, Madhavi Derangula, K. Ruhinaz, K. Panati, P. Subramani, V. R. A. Tatireddigari
Immunologists have long considered inflammation to be a two-edged sword. Short term inflammation can be beneficial but long term chronic inflammation is damaging. Obesity, type 2 diabetes (T2D), and cancer have recently been added to the never-ending list of inflammatory diseases. The nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR-γ) is involved in inflammation and obesity. Clinicians employed PPAR-γ agonists, both synthetic and natural, to treat disorders such as obesity and T2D without fully understanding the biochemical features and potential adverse effects. This is one of the reasons for the controversy surrounding the thiazolidinedione class of medicines, including rosiglitazone and pioglitazone.
{"title":"Natural product ligands of the peroxisome proliferator-activated receptor gamma as anti-inflammatory mediators","authors":"V. Narala, Madhavi Derangula, K. Ruhinaz, K. Panati, P. Subramani, V. R. A. Tatireddigari","doi":"10.2174/2210315512666220907150542","DOIUrl":"https://doi.org/10.2174/2210315512666220907150542","url":null,"abstract":"\u0000\u0000Immunologists have long considered inflammation to be a two-edged sword. Short term inflammation can be beneficial but long term chronic inflammation is damaging. Obesity, type 2 diabetes (T2D), and cancer have recently been added to the never-ending list of inflammatory diseases. The nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR-γ) is involved in inflammation and obesity. Clinicians employed PPAR-γ agonists, both synthetic and natural, to treat disorders such as obesity and T2D without fully understanding the biochemical features and potential adverse effects. This is one of the reasons for the controversy surrounding the thiazolidinedione class of medicines, including rosiglitazone and pioglitazone.\u0000","PeriodicalId":56153,"journal":{"name":"Natural Products Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45798591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：