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Understanding COVID-19: comparison of spatio-temporal analysis methods used to study epidemic spread patterns in the United States. 了解COVID-19:用于研究美国流行病传播模式的时空分析方法的比较。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1200
Chunhui Liu, Xiaodi Su, Zhaoxuan Dong, Xingyu Liu, Chunxia Qiu

This article examines three spatiotemporal methods used for analyzing of infectious diseases, with a focus on COVID-19 in the United States. The methods considered include inverse distance weighting (IDW) interpolation, retrospective spatiotemporal scan statistics and Bayesian spatiotemporal models. The study covers a 12-month period from May 2020 to April 2021, including monthly data from 49 states or regions in the United States. The results show that the spread of COVID-19 pandemic increased rapidly to a high value in winter of 2020, followed by a brief decline that later reverted into another increase. Spatially, the COVID-19 epidemic in the United States exhibited a multi-centre, rapid spread character, with clustering areas represented by states such as New York, North Dakota, Texas and California. By demonstrating the applicability and limitations of different analytical tools in investigating the spatiotemporal dynamics of disease outbreaks, this study contributes to the broader field of epidemiology and helps improve strategies for responding to future major public health events.

本文考察了用于分析传染病的三种时空方法,重点介绍了美国的COVID-19。考虑的方法包括逆距离加权插值、回顾性时空扫描统计和贝叶斯时空模型。该研究涵盖了从2020年5月到2021年4月的12个月,包括美国49个州或地区的月度数据。结果表明,2019冠状病毒病大流行传播在2020年冬季迅速上升至高位,随后短暂下降,随后又转为上升。从空间上看,美国新冠肺炎疫情呈现多中心、快速传播特征,以纽约州、北达科他州、德克萨斯州和加利福尼亚州为集聚区。通过展示不同分析工具在调查疾病暴发时空动态中的适用性和局限性,本研究有助于拓宽流行病学领域,并有助于改进应对未来重大公共卫生事件的策略。
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引用次数: 0
A spatiotemporal analysis of the social determinants of health for COVID-19. COVID-19健康社会决定因素时空分析
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1153
Claire Bonzani, Peter Scull, Daisaku Yamamoto

This research aims to uncover how the association between social determinants of health and COVID-19 cases and fatality rate have changed across time and space. To begin to understand these associations and show the benefits of analysing temporal and spatial variations in COVID-19, we utilized Geographically Weighted Regression (GWR). The results emphasize the advantages for using GWR in data with a spatial component, while showing the changing spatiotemporal magnitude of association between a given social determinant and cases or fatalities. While previous research has demonstrated the merits of GWR for spatial epidemiology, our study fills a gap in the literature, by examining a suite of variables across time to reveal how the pandemic unfolded across the US at a county-level spatial scale. The results speak to the importance of understanding the local effects that a social determinant may have on populations at the county level. From a public health perspective, these results can be used for an understanding of the disproportionate disease burden felt by different populations, while upholding and building upon trends observed in epidemiological literature.

这项研究旨在揭示健康的社会决定因素与COVID-19病例和死亡率之间的关系如何随着时间和空间的变化而变化。为了开始了解这些关联并展示分析COVID-19时空变化的好处,我们使用了地理加权回归(GWR)。研究结果强调了在具有空间成分的数据中使用GWR的优势,同时显示了给定社会决定因素与病例或死亡之间不断变化的时空关联程度。虽然以前的研究已经证明了GWR在空间流行病学方面的优点,但我们的研究填补了文献中的空白,通过研究一系列随时间变化的变量,揭示了疫情在美国县级空间尺度上的发展情况。研究结果表明,了解一个社会决定因素可能对县一级人口产生的局部影响是非常重要的。从公共卫生的角度来看,这些结果可用于了解不同人群所感受到的不成比例的疾病负担,同时支持和发展流行病学文献中观察到的趋势。
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引用次数: 0
Prediction of dengue cases using the attention-based long short-term memory (LSTM) approach. 利用基于注意的长短期记忆方法预测登革热病例。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1176
Mokhalad A Majeed, Helmi Z M Shafri, Aimrun Wayayok, Zed Zulkafli

This research proposes a 'temporal attention' addition for long-short term memory (LSTM) models for dengue prediction. The number of monthly dengue cases was collected for each of five Malaysian states i.e. Selangor, Kelantan, Johor, Pulau Pinang, and Melaka from 2011 to 2016. Climatic, demographic, geographic and temporal attributes were used as covariates. The proposed LSTM models with temporal attention was compared with several benchmark models including a linear support vector machine (LSVM), a radial basis function support vector machine (RBFSVM), a decision tree (DT), a shallow neural network (SANN) and a deep neural network (D-ANN). In addition, experiments were conducted to analyze the impact of look-back settings on each model performance. The results showed that the attention LSTM (A-LSTM) model performed best, with the stacked, attention LSTM (SA-LSTM) one in second place. The LSTM and stacked LSTM (S-LSTM) models performed almost identically but with the accuracy improved by the attention mechanism was added. Indeed, they were both found to be superior to the benchmark models mentioned above. The best results were obtained when all attributes were included in the model. The four models (LSTM, S-LSTM, A-LSTM and SA-LSTM) were able to accurately predict dengue presence 1-6 months ahead. Our findings provide a more accurate dengue prediction model than previously used, with the prospect of also applying this approach in other geographic areas.

这项研究为登革热预测的长短期记忆(LSTM)模型增加了“时间注意”。2011年至2016年,收集了马来西亚五个州(雪兰莪州、吉兰丹州、柔佛州、槟榔岛州和马六甲州)的每月登革热病例数。使用气候、人口、地理和时间属性作为协变量。将该模型与线性支持向量机(LSVM)、径向基函数支持向量机(RBFSVM)、决策树(DT)、浅神经网络(SANN)和深度神经网络(D-ANN)等基准模型进行了比较。此外,通过实验分析了回溯设置对各模型性能的影响。结果表明,注意LSTM (A-LSTM)模型表现最好,其次是堆叠的注意LSTM (SA-LSTM)模型。LSTM和堆叠LSTM (S-LSTM)模型的准确率基本一致,但由于加入了注意机制而提高了准确率。事实上,它们都优于上面提到的基准模型。当模型中包含所有属性时,得到的结果最好。4个模型(LSTM、S-LSTM、A-LSTM和SA-LSTM)能够提前1-6个月准确预测登革热的存在。我们的发现提供了一种比以前使用的更准确的登革热预测模型,并有望将这种方法应用于其他地理区域。
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引用次数: 1
A geospatial study of the coverage of catheterization laboratory facilities (cath labs) and the travel time required to reach them in East Java, Indonesia. 对印度尼西亚东爪哇导尿实验室设施(导管室)的覆盖范围和到达这些设施所需的旅行时间的地理空间研究。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1164
Andrianto Andrianto, Farizal Rizky Muharram, Chaq El Chaq Zamzam Multazam, Wigaviola Socha, Doni Firman, Ahmad Chusnu Romdhoni, Senitza Anisa Salsabilla

Coronary heart disease is a non-communicable disease whose treatment is closely related to infrastructure, such as diagnostic imaging equipment visualizing arteries and chambers of the heart (cath lab) and infrastructure that supports access to healthcare. This research is intended as a preliminary geospatial study to carry out initial measurements of health facility coverage at the regional level, survey available supporting data and provide input on problems in future research. Data on cath lab presence was gathered through direct survey, while population data was taken from an open-source geospatial system. The cath lab service coverage was obtained by analysis based on a Geographical Information System (GIS) specific tool to evaluate travel time from the sub-district centre to the nearest cath lab facility. The number of cath labs in East Java has increased from 16 to 33 in the last six years and the 1-hour access time increased from 24.2% to 53.8%. However, accessibility remains a problem as16.5% of the total population of East Java cannot access a cath lab even within 2 hours. Thus, additional cath lab facilities are required to provide ideal healthcare coverage. Geospatial analysis is the tool to determine the optimal cath lab distribution.

冠心病是一种非传染性疾病,其治疗与基础设施密切相关,例如显示动脉和心室的诊断成像设备(导管实验室)和支持获得医疗保健的基础设施。这项研究旨在作为一项初步的地理空间研究,对区域一级的卫生设施覆盖率进行初步测量,调查现有的支持数据,并就今后研究中的问题提供投入。导管室存在的数据通过直接调查收集,而人口数据来自开源地理空间系统。通过基于地理信息系统(GIS)特定工具的分析,评估从街道中心到最近的导管室设施的旅行时间,获得了导管室服务覆盖率。在过去6年中,东爪哇的导管室数量从16个增加到33个,1小时访问时间从24.2%增加到53.8%。然而,无障碍仍然是一个问题,因为东爪哇总人口的16.5%无法在2小时内进入导管室。因此,需要额外的导管室设施来提供理想的医疗保险。地理空间分析是确定最佳导管室分布的工具。
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引用次数: 0
Spatial autocorrelation and heterogenicity of demographic and healthcare factors in the five waves of COVID-19 epidemic in Thailand. 泰国五波新冠肺炎疫情中人口与卫生保健因素的空间自相关及异质性
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1183
Ei Sandar U, Wongsa Laohasiriwong, Kittipong Sornlorm

A study of 2,569,617 Thailand citizens diagnosed with COVID-19 from January 2020 to March 2022 was conducted with the aim of identifying the spatial distribution pattern of incidence rate of COVID-19 during its five main waves in all 77 provinces of the country. Wave 4 had the highest incidence rate (9,007 cases per 100,000) followed by the Wave 5, with 8,460 cases per 100,000. We also determined the spatial autocorrelation between a set of five demographic and health care factors and the spread of the infection within the provinces using Local Indicators of Spatial Association (LISA) and univariate and bivariate analysis with Moran's I. The spatial autocorrelation between the variables examined and the incidence rates was particularly strong during the waves 3-5. All findings confirmed the existence of spatial autocorrelation and heterogenicity of COVID-19 with the distribution of cases with respect to one or several of the five factors examined. The study identified significant spatial autocorrelation with regard to the COVID-19 incidence rate with these variables in all five waves. Depending on which province that was investigated, strong spatial autocorrelation of the High-High pattern was observed in 3 to 9 clusters and of the Low-Low pattern in 4 to 17 clusters, whereas negative spatial autocorrelation was observed in 1 to 9 clusters of the High-Low pattern and in 1 to 6 clusters of Low-High pattern. These spatial data should support stakeholders and policymakers in their efforts to prevent, control, monitor and evaluate the multidimensional determinants of the COVID-19 pandemic.

对2020年1月至2022年3月期间诊断为COVID-19的2,569,617名泰国公民进行了一项研究,目的是确定该国所有77个省份COVID-19在其五个主要波浪期间发病率的空间分布格局。第4波发病率最高(每10万人中有9,007例),其次是第5波,每10万人中有8,460例。我们还利用地方空间关联指标(Local Indicators of spatial Association, LISA)和Moran's i的单变量和双变量分析,确定了5个人口和卫生保健因素与省内感染传播之间的空间自相关性。所有研究结果都证实了COVID-19与病例分布之间存在空间自相关性和异质性,这与所检查的五个因素中的一个或几个因素有关。该研究发现,在所有五波中,这些变量与COVID-19发病率存在显著的空间自相关性。在不同省份,3 ~ 9个“高-高”区和4 ~ 17个“低-低”区存在强空间自相关,1 ~ 9个“高-低”区和1 ~ 6个“低-高”区存在负空间自相关。这些空间数据应支持利益攸关方和决策者努力预防、控制、监测和评估COVID-19大流行的多维决定因素。
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引用次数: 2
Dynamic effect of economic growth on the persistence of suicide rates. 经济增长对自杀率持续性的动态影响。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1201
Tzu-Yi Yang, Yu-Tai Yang, Ssu-Han Chen, Yu-Ting Lan, Chia-Jui Peng

Positive and negative economic growth is closely related to the suicide rate. To answer the question whether economic development has a dynamic impact on this rate, we used a panel smooth transition autoregressive model to evaluate the threshold effect of economic growth rate on the persistence of suicide. The research period was from 1994 to 2020, and the results show that the suicide rate had a persistent effect, which varied over time depending on the transition variable within different threshold intervals. However, the persistent effect was manifested in different degrees with the change in the economic growth rate and as the lag period of the suicide rate increased, the effect of the influence gradually decreased. We investigated different lag periods and noted that the impact on the suicide rate was the strongest in the first year after an economic change and then reduced to be only marginal after three years. This means that the growth momentum of the suicide rate within the first two years after a change in the economic growth rate, should be included in policy considerations of how to prevent suicides.

经济的正负增长与自杀率密切相关。为了回答经济发展是否对自杀持续率有动态影响的问题,我们使用面板平滑过渡自回归模型来评估经济增长率对自杀持续率的阈值效应。研究时间为1994年至2020年,结果表明自杀率具有持续性影响,且随时间的变化取决于不同阈值区间内的过渡变量。然而,随着经济增长率的变化,这种持续效应不同程度地表现出来,随着自杀率滞后期的增加,其影响效果逐渐减弱。我们调查了不同的滞后期,并注意到对自杀率的影响在经济变化后的第一年是最强的,然后在三年后减少到只有边际。这意味着,在经济增长率发生变化后的前两年内,自杀率的增长势头,应纳入如何预防自杀的政策考虑。
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引用次数: 0
Spatial and temporal clustering analysis of pulmonary tuberculosis and its associated risk factors in southwest China. 西南地区肺结核及其相关危险因素时空聚类分析
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1169
Jianjiao Wang, Xiaoning Liu, Zhengchao Jing, Jiawai Yang

Pulmonary tuberculosis (PTB) remains a serious public health problem, especially in areas of developing countries. This study aimed to explore the spatial-temporal clusters and associated risk factors of PTB in south-western China. Space-time scan statistics were used to explore the spatial and temporal distribution characteristics of PTB. We collected data on PTB, population, geographic information and possible influencing factors (average temperature, average rainfall, average altitude, planting area of crops and population density) from 11 towns in Mengzi, a prefecture-level city in China, between 1 January 2015 and 31 December 2019. A total of 901 reported PTB cases were collected in the study area and a spatial lag model was conducted to analyse the association between these variables and the PTB incidence. Kulldorff's scan results identified two significant space-time clusters, with the most likely cluster (RR = 2.24, p < 0.001) mainly located in northeastern Mengzi involving five towns in the time frame June 2017 - November 2019. A secondary cluster (RR = 2.09, p < 0.05) was located in southern Mengzi, covering two towns and persisting from July 2017 to December 2019. The results of the spatial lag model showed that average rainfall was associated with PTB incidence. Precautions and protective measures should be strengthened in high-risk areas to avoid spread of the disease.

肺结核仍然是一个严重的公共卫生问题,特别是在发展中国家的一些地区。本研究旨在探讨中国西南地区肺结核的时空分布特征及其相关危险因素。采用时空扫描统计方法探讨PTB的时空分布特征。在2015年1月1日至2019年12月31日期间,我们收集了中国蒙自市11个镇的肺结核、人口、地理信息和可能的影响因素(平均温度、平均降雨量、平均海拔、作物种植面积和人口密度)数据。收集研究区901例PTB报告病例,采用空间滞后模型分析这些变量与PTB发病率之间的关系。Kulldorff的扫描结果确定了两个显著的时空集群,其中最可能的集群(RR = 2.24, p < 0.001)主要位于蒙自东北部,涉及2017年6月至2019年11月期间的五个城镇。第二个聚集区(RR = 2.09, p < 0.05)位于蒙自南部,覆盖两个镇,持续时间为2017年7月至2019年12月。空间滞后模型结果表明,平均降雨量与肺结核发病率相关。高危地区应加强预防和防护措施,避免疫情传播。
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引用次数: 0
Spatial analysis of the relationship between out-of-pocket expenditure and socioeconomic status in South Korea. 韩国自费支出与社会经济地位关系的空间分析。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1175
Young-Gyu Kwon, Man-Kyu Choi

The rapid increase in out-of-pocket expenditures regressively raises the issue of equity in medical access opportunities according to income class and negatively affects public health. Factors related to out-of-pocket expenses have been analyzed in previous studies using an ordinary regression model (Ordinary Least Squares [OLS]). However, as OLS assumes equal error variance, it does not consider spatial variation due to spatial heterogeneity and dependence. Accordingly, this study presents a spatial analysis of outpatient out-of-pocket expenses from 2015 to 2020, targeting 237 local governments nationwide, excluding islands and island regions. R (version 4.1.1) was used for statistical analysis, and QGIS (version 3.10.9), GWR4 (version 4.0.9), and Geoda (version 1.20.0.10) were used for the spatial analysis. As a result, in OLS, it was found that the aging rate and number of general hospitals, clinics, public health centers, and beds had a positive (+) significant effect on outpatient out-of-pocket expenses. The Geographically Weighted Regression (GWR) suggests regional differences exist concerning out-of-pocket payments. As a result of comparing the OLS and GWR models through the Adj. R² and Akaike's Information Criterion indices, the GWR model showed a higher fit. This study provides public health professionals and policymakers with insights that could inform effective regional strategies for appropriate out-of-pocket cost management.

自付支出的迅速增加,逐渐引起了按收入阶层公平获得医疗机会的问题,并对公共卫生产生负面影响。之前的研究使用普通回归模型(普通最小二乘法[OLS])分析了与自付费用相关的因素。然而,由于OLS假设误差方差相等,因此没有考虑空间异质性和依赖性带来的空间变异。据此,本研究对2015 - 2020年全国237个地方政府(不包括岛屿和岛屿地区)的门诊自付费用进行了空间分析。采用R(版本4.1.1)进行统计分析,采用QGIS(版本3.10.9)、GWR4(版本4.0.9)、Geoda(版本1.20.0.10)进行空间分析。结果发现,在OLS中,综合医院、诊所、公共卫生中心和床位的老龄化率和数量对门诊自付费用有正(+)显著影响。地理加权回归(GWR)表明,自费支付存在地区差异。通过Adj. R²和赤池信息准则指标对OLS模型和GWR模型进行比较,GWR模型具有较高的拟合性。这项研究为公共卫生专业人员和政策制定者提供了见解,可以为适当的自付费用管理的有效区域战略提供信息。
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引用次数: 0
Spatial analysis of antimicrobial resistance in the environment. A systematic review. 环境中抗菌素耐药性的空间分析。系统回顾。
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1168
Patrick Spets, Karin Ebert, Patrik Dinnétz

Antimicrobial resistance (AMR) is a global major health concern. Spatial analysis is considered an invaluable method in health studies. Therefore, we explored the usage of spatial analysis in Geographic Information Systems (GIS) in studies on AMR in the environment. This systematic review is based on database searches, a content analysis, ranking of the included studies according to the preference ranking organization method for enrichment evaluations (PROMETHEE) and estimation of data points per km2. Initial database searches resulted in 524 records after removal of duplicates. After the last stage of full text screening, 13 greatly heterogeneous articles with diverse study origins, methods and design remained. In the majority of studies, the data density was considerably less than one sampling site per km2 but exceeded 1,000 sites per km2 in one study. The results of the content analysis and ranking showed a variation between studies that primarily used spatial analysis and those that used spatial analysis as a sec ondary method. We identified two distinct groups of GIS methods. The first was focused on sample collection and laboratory testing, with GIS as supporting method. The second group used overlay analysis as the primary method to combine datasets in a map. In one case, both methods were combined. The low number of articles that met our inclusion criteria highlights a research gap. Based on the findings of this study we encourage application of GIS to its full potential in studies of AMR in the environment.

抗菌素耐药性(AMR)是一个全球性的重大卫生问题。空间分析被认为是健康研究的宝贵方法。因此,我们探索了地理信息系统(GIS)空间分析在环境中抗菌素耐药性研究中的应用。该系统评价基于数据库搜索、内容分析、根据富集评价偏好排序组织方法(PROMETHEE)对纳入的研究进行排序和每平方公里数据点的估计。删除重复项后,初始数据库搜索得到524条记录。经过最后一阶段的全文筛选,仍有13篇研究来源、方法和设计差异很大的异质性文章。在大多数研究中,数据密度远远少于每平方公里一个采样点,但在一项研究中每平方公里超过1 000个采样点。内容分析和排名的结果显示,主要使用空间分析的研究与将空间分析作为次要方法的研究之间存在差异。我们确定了两组不同的GIS方法。第一个侧重于样本收集和实验室测试,以GIS作为辅助方法。第二组使用叠加分析作为在地图中组合数据集的主要方法。在一个案例中,两种方法结合在一起。符合我们纳入标准的文章数量少凸显了研究差距。基于这项研究的结果,我们鼓励GIS在环境抗菌素耐药性研究中充分发挥其潜力。
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引用次数: 0
Does mobility restriction significantly control infectious disease transmission? Accounting for non-stationarity in the impact of COVID-19 based on Bayesian spatially varying coefficient models. 限制行动是否能有效控制传染病的传播?基于贝叶斯空间变系数模型的新冠肺炎影响非平稳性分析
IF 1.7 4区 医学 Q4 HEALTH CARE SCIENCES & SERVICES Pub Date : 2023-05-25 DOI: 10.4081/gh.2023.1161
I Gede Nyoman Mindra Jaya, Anna Chadidjah, Farah Kristiani, Gumgum Darmawan, Jane Christine Princidy

COVID-19 is the most severe health crisis of the 21st century. COVID-19 presents a threat to almost all countries worldwide. The restriction of human mobility is one of the strategies used to control the transmission of COVID-19. However, it has yet to be determined how effective this restriction is in controlling the rise in COVID-19 cases, particularly in small areas. Using Facebook's mobility data, our study explores the impact of restricting human mobility on COVID-19 cases in several small districts in Jakarta, Indonesia. Our main contribution is showing how the restriction of human mobility data can give important information about how COVID-19 spreads in different small areas. We proposed modifying a global regression model into a local regression model by accounting for the spatial and temporal interdependence of COVID-19 transmission across space and time. We applied Bayesian hierarchical Poisson spatiotemporal models with spatially varying regression coefficients to account for non-stationarity in human mobility. We estimated the regression parameters using an Integrated Nested Laplace Approximation. We found that the local regression model with spatially varying regression coefficients outperforms the global regression model based on DIC, WAIC, MPL, and R2 criteria for model selection. In Jakarta's 44 districts, the impact of human mobility varies significantly. The impacts of human mobility on the log relative risk of COVID-19 range from -4.445 to 2.353. The prevention strategy involving the restriction of human mobility may be beneficial in some districts but ineffective in others. Therefore, a cost-effective strategy had to be adopted.

COVID-19是21世纪最严重的健康危机。COVID-19对全球几乎所有国家都构成威胁。限制人员流动是控制COVID-19传播的策略之一。然而,这一限制在控制COVID-19病例增加方面的效果如何,特别是在小地区,还有待确定。利用Facebook的流动性数据,我们的研究探讨了限制人员流动对印度尼西亚雅加达几个小地区的COVID-19病例的影响。我们的主要贡献是展示了限制人员流动数据如何提供有关COVID-19如何在不同小区域传播的重要信息。考虑到COVID-19传播在时空上的相互依赖性,我们提出将全局回归模型修正为局部回归模型。我们应用贝叶斯层次泊松时空模型与空间变化的回归系数来解释人类流动性的非平稳性。我们使用集成嵌套拉普拉斯近似估计回归参数。我们发现,具有空间变化回归系数的局部回归模型在模型选择上优于基于DIC、WAIC、MPL和R2标准的全局回归模型。在雅加达的44个区,人口流动的影响差别很大。人员流动对新冠肺炎对数相对风险的影响范围为-4.445 ~ 2.353。限制人员流动的预防战略在某些地区可能是有益的,但在其他地区则无效。因此,必须采取具有成本效益的战略。
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