Paweł Stanicki, Klaudia Szukała, Małgorzata Szypłowska, Michał Dzikowski
Abstract Introduction: Refeeding syndrome RS is a life-threatening acute hormonal and metabolic disorder that occurs in patients with moderate or severe malnutrition as a result of improperly administered nutritional therapy. Material and method: The aim of this study is to describe the cases of two female patients suffering from anorexia nervosa, who developed a refeeding syndrome after starting nutritional therapy. Additionally, the available literature was reviewed in order to characterize the issue, including negative consequences and prevention of the refeeding syndrome. Results: In both cases, the development of the refeeding syndrome was found in the patients, resulting from the excessive supply of energy and nutritional substrates in a short time, preceded by a previous, months long period of starvation and exhaustion of the organism (both patients had a decrease in the body mass index - BMI - to the value of about 14 kg / m2). In patient 1, the symptoms concerned mainly the cardiovascular system: a significant increase in the concentration of N-terminal B-type natriuretic propeptide (NT-proBNP) and tachycardia, as well as a decrease in the concentration of inorganic phosphates and hypokalemia. On the other hand, in the case of patient 2, symptoms such as confusion or deep disturbances of consciousness, which led to hospitalization in the intensive care unit, dominated the clinical picture. Conclusions: Refeeding syndrome may develop during nutritional rehabilitation, especially in the case of a sudden, inadequately planned supply of nutrients. Particular care should be taken in patients with extremely low BMI when reintroducing nutrition. The presented case reports draw attention to the possibility of cardiological complications and mental disorders of the realimentation syndrome, and indicate the behavior of patients (eating excessive food) that may lead to the development of the refeeding syndrome.
摘要简介:再喂养综合征(RS)是一种危及生命的急性激素和代谢紊乱，发生在中度或重度营养不良患者中，由于给予不当的营养治疗。材料与方法:本研究的目的是描述两名女性神经性厌食症患者在开始营养治疗后出现再进食综合征的病例。此外，对现有文献进行了回顾，以确定问题的特征，包括负面后果和预防再进食综合征。结果:在这两种情况下，患者都发现了再进食综合征的发展，这是由于能量和营养基质在短时间内供应过量，之前是长达数月的饥饿和机体衰竭(两名患者的体重指数- BMI -降至约14 kg / m2的值)。患者1的症状主要涉及心血管系统:n端b型利钠前肽(NT-proBNP)浓度显著升高，心动过速，无机磷酸盐浓度降低，低钾血症。另一方面，在患者2的情况下，精神错乱或意识深度障碍等症状导致了重症监护病房的住院，这些症状在临床表现中占主导地位。结论:营养康复过程中可能出现再喂养综合征，特别是在突然、营养供应不充分的情况下。BMI极低的患者在重新引入营养时应特别小心。这些病例报告引起了人们对实现综合征的心血管并发症和精神障碍的关注，并指出了患者的行为(进食过量)可能导致再进食综合征的发展。
{"title":"Refeeding syndrome in patients with anorexia nervosa - case reports","authors":"Paweł Stanicki, Klaudia Szukała, Małgorzata Szypłowska, Michał Dzikowski","doi":"10.2478/cpp-2021-0017","DOIUrl":"https://doi.org/10.2478/cpp-2021-0017","url":null,"abstract":"Abstract Introduction: Refeeding syndrome RS is a life-threatening acute hormonal and metabolic disorder that occurs in patients with moderate or severe malnutrition as a result of improperly administered nutritional therapy. Material and method: The aim of this study is to describe the cases of two female patients suffering from anorexia nervosa, who developed a refeeding syndrome after starting nutritional therapy. Additionally, the available literature was reviewed in order to characterize the issue, including negative consequences and prevention of the refeeding syndrome. Results: In both cases, the development of the refeeding syndrome was found in the patients, resulting from the excessive supply of energy and nutritional substrates in a short time, preceded by a previous, months long period of starvation and exhaustion of the organism (both patients had a decrease in the body mass index - BMI - to the value of about 14 kg / m2). In patient 1, the symptoms concerned mainly the cardiovascular system: a significant increase in the concentration of N-terminal B-type natriuretic propeptide (NT-proBNP) and tachycardia, as well as a decrease in the concentration of inorganic phosphates and hypokalemia. On the other hand, in the case of patient 2, symptoms such as confusion or deep disturbances of consciousness, which led to hospitalization in the intensive care unit, dominated the clinical picture. Conclusions: Refeeding syndrome may develop during nutritional rehabilitation, especially in the case of a sudden, inadequately planned supply of nutrients. Particular care should be taken in patients with extremely low BMI when reintroducing nutrition. The presented case reports draw attention to the possibility of cardiological complications and mental disorders of the realimentation syndrome, and indicate the behavior of patients (eating excessive food) that may lead to the development of the refeeding syndrome.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"56 1","pages":"239 - 246"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78853464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Approximately 26% of individuals between 18 and 24 years old are overweight or obese, and the number of persons with excessive body mass index (BMI) is growing. Obesity increases the risk of metabolic disruptions, which is well connected with mental health problems. Stressful situations, including entering adulthood and starting university education, affect food choices negatively. The aim of the study was to examine the relationship between psychological stress and body composition in the student population. Materials and methods: The study group consisted of 80 students (76% of women and 24% of men) between 19 and 28 years old from universities in Lublin. To determine anthropometric measurement (fat-free mass (FFM), fat mass (FM), total body water (TBW), intracellular (ICF) and extracellular (ECF) fluids), bioelectrical impedance analysis (BIA) method was applied. The severity of stress symptoms was measured using Perceived Stress Scale (PSS-10). Results: When it comes to 41.25% of participants, they used relaxation techniques, mainly meditation, yoga practice and walking. Most students had optimal body weight. While 60% of individuals had high stress levels. The perceived stress was not related to using the relaxation methods. Individuals with the high stress severity were characterized by lower: TBW, ECF and ICF expressed in liters, and lower FFM represented in kilograms. The inverse relationship between the severity of stress and the aforementioned parameters was also detected (p<0.05). Conclusions: Implementing appropriate healt h education programs to prevent negat ive changes in ant hropometric measurements, psychological stress, and their health-related consequences in the student population should be considered.
{"title":"The interaction between stress and metabolic disruption in student population – preliminary study","authors":"J. Rog, Zuzanna Rząd, H. Karakuła-Juchnowicz","doi":"10.2478/cpp-2021-0022","DOIUrl":"https://doi.org/10.2478/cpp-2021-0022","url":null,"abstract":"Abstract Introduction: Approximately 26% of individuals between 18 and 24 years old are overweight or obese, and the number of persons with excessive body mass index (BMI) is growing. Obesity increases the risk of metabolic disruptions, which is well connected with mental health problems. Stressful situations, including entering adulthood and starting university education, affect food choices negatively. The aim of the study was to examine the relationship between psychological stress and body composition in the student population. Materials and methods: The study group consisted of 80 students (76% of women and 24% of men) between 19 and 28 years old from universities in Lublin. To determine anthropometric measurement (fat-free mass (FFM), fat mass (FM), total body water (TBW), intracellular (ICF) and extracellular (ECF) fluids), bioelectrical impedance analysis (BIA) method was applied. The severity of stress symptoms was measured using Perceived Stress Scale (PSS-10). Results: When it comes to 41.25% of participants, they used relaxation techniques, mainly meditation, yoga practice and walking. Most students had optimal body weight. While 60% of individuals had high stress levels. The perceived stress was not related to using the relaxation methods. Individuals with the high stress severity were characterized by lower: TBW, ECF and ICF expressed in liters, and lower FFM represented in kilograms. The inverse relationship between the severity of stress and the aforementioned parameters was also detected (p<0.05). Conclusions: Implementing appropriate healt h education programs to prevent negat ive changes in ant hropometric measurements, psychological stress, and their health-related consequences in the student population should be considered.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"1 1","pages":"312 - 317"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79920167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract The aim of the presented study is to verify whether the visual methods (Mind Maps and Sketch-noting) considered as metacognitive strategies will help to strengthen emotional and motivational self-regulation in children with ADHD. In this experimental study, 135 participants took part, including 45 primary school students diagnosed with attention deficit hyperactivity disorder with the presentation of mixed symptoms (M = 10.41; SD = 1.42), their parents (N = 45) and teachers (N = 45). The results obtained in the study indicate that after 25 training sessions with the use of both Mind Maps and Sketch-noting, children with ADHD make significantly fewer errors than during the first measurement. However, only in the Sketch-noting group did their average reaction time increase significantly, which indicates that they are more reflective. The presented metacognitive strategies can be successfully applied at school by students with ADHD and constitute a source of support for both students and teachers.
{"title":"Application of metacognitive strategies in the development of emotional and motivational self-regulation of students with special educational needs. Research on children with ADHD","authors":"Kajka Natalia, Kulik Agnieszka","doi":"10.2478/cpp-2021-0020","DOIUrl":"https://doi.org/10.2478/cpp-2021-0020","url":null,"abstract":"Abstract The aim of the presented study is to verify whether the visual methods (Mind Maps and Sketch-noting) considered as metacognitive strategies will help to strengthen emotional and motivational self-regulation in children with ADHD. In this experimental study, 135 participants took part, including 45 primary school students diagnosed with attention deficit hyperactivity disorder with the presentation of mixed symptoms (M = 10.41; SD = 1.42), their parents (N = 45) and teachers (N = 45). The results obtained in the study indicate that after 25 training sessions with the use of both Mind Maps and Sketch-noting, children with ADHD make significantly fewer errors than during the first measurement. However, only in the Sketch-noting group did their average reaction time increase significantly, which indicates that they are more reflective. The presented metacognitive strategies can be successfully applied at school by students with ADHD and constitute a source of support for both students and teachers.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"33 1","pages":"284 - 293"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81252242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mateusz Koch, K. Chmielowiec, Elzbieta Grzywacz, A. Suchanecka, J. Masiak, Jolanta Chmielowiec
Abstract Introduction: The COVID-19 is a disease caused by the SARS-CoV-2 virus. A number of psychological symptoms have been identified in people living during the COVID-19 pandemic. Most of them are associated with widely understood anxiety disorders, which have always been a significant problem for mental health. Materials and methods: The available literature was reviewed on the Pubmed platform and from other sources. The analysis included original studies, reviews, meta-analyzes and internet sources. The aim of the study was to review the literature on the relationship between the COVID-19 pandemic and the occurrence and severity of symptoms of anxiety disorders. Results: The studies conducted so far show that the COVID-19 pandemic has had a significant impact on the mental state of people around the world, especially in the area of anxiety disorders. Many studies indicate an increase in the prevalence of symptoms of generalized anxiety disorder. Research also indicates a greater incidence of post-traumatic stress disorder and panic disorder in society. Symptoms of somatization were also quite often observed in patients. However, the state of published studies indicates that the pandemic did not significantly affect the severity of symptoms associated with social phobia. In the context of phobic disorders, a new type has been formulated: COVID-19-related phobia. Conclusions: The conducted literature review shows that the current COVID-19 pandemic is associated with an increase in the prevalence of symptoms of anxiety disorders in the general population. The multifaceted nature of the issue of anxiety disorders in the COVID-19 pandemic clearly indicates the need to continue research in this area.
{"title":"The impact of the COVID-19 pandemic on the development of anxiety disorders - a literature review","authors":"Mateusz Koch, K. Chmielowiec, Elzbieta Grzywacz, A. Suchanecka, J. Masiak, Jolanta Chmielowiec","doi":"10.2478/cpp-2021-0024","DOIUrl":"https://doi.org/10.2478/cpp-2021-0024","url":null,"abstract":"Abstract Introduction: The COVID-19 is a disease caused by the SARS-CoV-2 virus. A number of psychological symptoms have been identified in people living during the COVID-19 pandemic. Most of them are associated with widely understood anxiety disorders, which have always been a significant problem for mental health. Materials and methods: The available literature was reviewed on the Pubmed platform and from other sources. The analysis included original studies, reviews, meta-analyzes and internet sources. The aim of the study was to review the literature on the relationship between the COVID-19 pandemic and the occurrence and severity of symptoms of anxiety disorders. Results: The studies conducted so far show that the COVID-19 pandemic has had a significant impact on the mental state of people around the world, especially in the area of anxiety disorders. Many studies indicate an increase in the prevalence of symptoms of generalized anxiety disorder. Research also indicates a greater incidence of post-traumatic stress disorder and panic disorder in society. Symptoms of somatization were also quite often observed in patients. However, the state of published studies indicates that the pandemic did not significantly affect the severity of symptoms associated with social phobia. In the context of phobic disorders, a new type has been formulated: COVID-19-related phobia. Conclusions: The conducted literature review shows that the current COVID-19 pandemic is associated with an increase in the prevalence of symptoms of anxiety disorders in the general population. The multifaceted nature of the issue of anxiety disorders in the COVID-19 pandemic clearly indicates the need to continue research in this area.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"10 1","pages":"332 - 339"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90890232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnieszka Permoda-Pachuta, M. Skibińska, M. Dmitrzak-Węglarz, F. Rybakowski
Abstract Introduction: This study attempts to assess the concentration of intracellular matrix metalloproteinase (MMP-9) before and after the treatment of depressive episodes with ECT therapy and also to correlate the concentration of this enzyme with the use of commonly used general anaesthetics. Materials and methods: The study group comprised of 37 patients hospitalized in the Department of Adult Psychiatry in Poznan, with a diagnosis of episodes of drug-resistant depression during the course of bipolar and unipolar affective disorders, and who were being treated using electroconvulsive therapy. For the purpose of inducing anaesthesia during the procedure propofol was used in 10 cases, thiopental in 9 cases. Propofol was alternated with ketamine in a further 10 cases and thiopental was alternated with ketamine in another 9 cases. In order to assess the intensity of depression symptoms, the 17 point Hamilton depression scale was used, immediately before commencing ECT therapy, and one day after its completion. The serum concentration of MMP-9 was determined before and after the series of ECT treatments. In order to assess the serum concentration of MMP-9, an ELISA immunoenzymatic method was applied. Results: In this study, a significant reduction of MMP-9 concentration was noted after therapy, relative to the starting concentration, in the serum of patients suffering from depressive episodes resulting from either unipolar or bipolar affective disorders. These results correlated with improved psychiatric state, as assessed by the Hamilton scale. A significantly lower MMP-9 concentration was noted in the serum of patients given alternating thiopental and ketamine anaesthesia. Conclusions: This study suggests the importance of the enzyme as a biological marker for the effective treatment of depression. Furthermore, the choice of general anaesthetic applied during ECT also plays a role.
{"title":"The concentration of MMP-9 and the effects of intravenous anaesthetics on the efficacy of electroconvulsive therapy in patients with drug-resistant depression","authors":"Agnieszka Permoda-Pachuta, M. Skibińska, M. Dmitrzak-Węglarz, F. Rybakowski","doi":"10.2478/cpp-2021-0023","DOIUrl":"https://doi.org/10.2478/cpp-2021-0023","url":null,"abstract":"Abstract Introduction: This study attempts to assess the concentration of intracellular matrix metalloproteinase (MMP-9) before and after the treatment of depressive episodes with ECT therapy and also to correlate the concentration of this enzyme with the use of commonly used general anaesthetics. Materials and methods: The study group comprised of 37 patients hospitalized in the Department of Adult Psychiatry in Poznan, with a diagnosis of episodes of drug-resistant depression during the course of bipolar and unipolar affective disorders, and who were being treated using electroconvulsive therapy. For the purpose of inducing anaesthesia during the procedure propofol was used in 10 cases, thiopental in 9 cases. Propofol was alternated with ketamine in a further 10 cases and thiopental was alternated with ketamine in another 9 cases. In order to assess the intensity of depression symptoms, the 17 point Hamilton depression scale was used, immediately before commencing ECT therapy, and one day after its completion. The serum concentration of MMP-9 was determined before and after the series of ECT treatments. In order to assess the serum concentration of MMP-9, an ELISA immunoenzymatic method was applied. Results: In this study, a significant reduction of MMP-9 concentration was noted after therapy, relative to the starting concentration, in the serum of patients suffering from depressive episodes resulting from either unipolar or bipolar affective disorders. These results correlated with improved psychiatric state, as assessed by the Hamilton scale. A significantly lower MMP-9 concentration was noted in the serum of patients given alternating thiopental and ketamine anaesthesia. Conclusions: This study suggests the importance of the enzyme as a biological marker for the effective treatment of depression. Furthermore, the choice of general anaesthetic applied during ECT also plays a role.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"17 1","pages":"318 - 331"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84423664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: In recent years, social networking sites (SNS), such as Facebook, Twitter or Instagram have gained immense popularity and have become an essential part of many people’s everyday lives. In Poland, 19 million people, i.e. about a half of the whole population, are active SNS users. Aim: The aim of the present study was to analyze the relationship of family and personality factors with daily SNS usage time in adolescents aged 14 to 19 years. Participants: The study included 291 junior-high and high school students aged 14–19 years. In this sample, 246 individuals had an SNS profile. Methods: The following instruments were used: an Inquiry Form designed by the present authors, Gough and Heilbrun’s Adjective Check List, the Coping with Stress Questionnaire by Janke, Erdmann and Boucsein and the Buss and Durkee Hostility-Guilt Inventory. Results: Based on correlation coefficients, significant associations were found between increased daily SNS usage and negative relationships with parents, maladaptive coping, and increased aggression. Conclusions: 1. Participants who spent more time using SNS were more likely to feel lonely in their families and have a sense of not being accepted and understood by their parents. 2. Young people who spent more time using SNS were more likely to respond to a stressful situation with a sense of helplessness and resignation and to cope by downplaying their problems and seeking substitute gratification or support. 3. Young people who spent more time using SNS were more likely to respond with indirect aggression, negativism, suspicion, hostility and verbal aggression.
{"title":"Family factors and personality factors affecting daily SNS usage in individuals aged 14-19 years","authors":"B. Pawłowska, Agnieszka Dyzma","doi":"10.2478/cpp-2021-0009","DOIUrl":"https://doi.org/10.2478/cpp-2021-0009","url":null,"abstract":"Abstract Introduction: In recent years, social networking sites (SNS), such as Facebook, Twitter or Instagram have gained immense popularity and have become an essential part of many people’s everyday lives. In Poland, 19 million people, i.e. about a half of the whole population, are active SNS users. Aim: The aim of the present study was to analyze the relationship of family and personality factors with daily SNS usage time in adolescents aged 14 to 19 years. Participants: The study included 291 junior-high and high school students aged 14–19 years. In this sample, 246 individuals had an SNS profile. Methods: The following instruments were used: an Inquiry Form designed by the present authors, Gough and Heilbrun’s Adjective Check List, the Coping with Stress Questionnaire by Janke, Erdmann and Boucsein and the Buss and Durkee Hostility-Guilt Inventory. Results: Based on correlation coefficients, significant associations were found between increased daily SNS usage and negative relationships with parents, maladaptive coping, and increased aggression. Conclusions: 1. Participants who spent more time using SNS were more likely to feel lonely in their families and have a sense of not being accepted and understood by their parents. 2. Young people who spent more time using SNS were more likely to respond to a stressful situation with a sense of helplessness and resignation and to cope by downplaying their problems and seeking substitute gratification or support. 3. Young people who spent more time using SNS were more likely to respond with indirect aggression, negativism, suspicion, hostility and verbal aggression.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81961700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julita Poleszak-Szabat, Małgorzata Romaniuk-Suswał, P. Krukow
Abstract Introduction: Although the typical symptoms of SARS-CoV-2 infection are respiratory symptoms, it has been shown that the virus can also attack the central nervous system (CNS) causing neurological and psychiatric symptoms. Aim: The aim of the study was to present a case of a 52-year-old woman, previously untreated for psychiatric diseases, who developed brief psychotic disorder occurring after Covid-19 infection. Case report: A patient in the biological treatment of asthma, came for a follow-up visit, during which the doctor diagnosed psychopathological symptoms in the form of delusions, never previously observed. The interview showed that the patient was discharged from the Isolation ward 10 days before, where she was hospitalized because of SARS-CoV-2 infection. Discussion: There are several theories regarding the mechanisms of pathogenesis of neuropsychiatric symptoms in the course of Covid-19 infection. Much space in the literature is devoted to pathological immune responses. One of the reasons for the development of delusions in the described patient could therefore be the acute phase of the inflammatory reaction in the course of SARS-CoV-2 infection.
{"title":"Brief psychotic disorder occurring after Covid-19 in a patient with no history of psychiatric diseases - a case report","authors":"Julita Poleszak-Szabat, Małgorzata Romaniuk-Suswał, P. Krukow","doi":"10.2478/cpp-2021-0014","DOIUrl":"https://doi.org/10.2478/cpp-2021-0014","url":null,"abstract":"Abstract Introduction: Although the typical symptoms of SARS-CoV-2 infection are respiratory symptoms, it has been shown that the virus can also attack the central nervous system (CNS) causing neurological and psychiatric symptoms. Aim: The aim of the study was to present a case of a 52-year-old woman, previously untreated for psychiatric diseases, who developed brief psychotic disorder occurring after Covid-19 infection. Case report: A patient in the biological treatment of asthma, came for a follow-up visit, during which the doctor diagnosed psychopathological symptoms in the form of delusions, never previously observed. The interview showed that the patient was discharged from the Isolation ward 10 days before, where she was hospitalized because of SARS-CoV-2 infection. Discussion: There are several theories regarding the mechanisms of pathogenesis of neuropsychiatric symptoms in the course of Covid-19 infection. Much space in the literature is devoted to pathological immune responses. One of the reasons for the development of delusions in the described patient could therefore be the acute phase of the inflammatory reaction in the course of SARS-CoV-2 infection.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"145 1","pages":"187 - 192"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88085380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction and aim: The SARS-CoV-2 pandemic had a significant impact on the mental condition of the society, increasing anxiety and fear for the future. High levels of anxiety, stress and depression have been observed in the general population. Nurses and doctors, who are in direct contact with patients and their body fluids, are at the highest risk of infection. The aim of this study was to look at the psychiatric health aspects of health care professionals in general during the pandemic. State of knowledge: Work overload and stress-related symptoms make healthcare workers particularly vulnerable to mental distress, increasing the risk of developing mental disorders. Among them, women, students and nurses were most affected. A German study found that nurses working with COVID-19 patients in particular are mentally affected by the consequences of the pandemic. This may be due to the higher workload and the longer time spent in direct contact with COVID-19 patients compared to doctors. The available literature confirmed the construct of coronaphobia in health care workers. The issue of insufficient personalization of protective equipment and the associated feelings of fear and stigma as well as the need for psychological help are addressed and psychiatric services for healthcare professionals. Material and methods: At the beginning of this year, 30 people from the clinical hospital in Lublin were surveyed using a questionnaire containing several questions concerning, among others, comfort of work in the current epidemiological situation, The Patient Health Questionnaire-9, The Generalized Anxiety Disorder-7 and Mini-COPE. Conclusions: The work shows the mental health problems faced by health service representatives on a daily basis in connection with the pandemic that has been going on for many months. The features of depression-anxiety disorders affect the medical staff. The attitude of solidarity and cooperation of all members of society during the pandemic is important.
{"title":"Pandemic heroes or victims? Healthcare professionals’ well-being during Covid-19 pandemic","authors":"E. Soroka","doi":"10.2478/cpp-2021-0012","DOIUrl":"https://doi.org/10.2478/cpp-2021-0012","url":null,"abstract":"Abstract Introduction and aim: The SARS-CoV-2 pandemic had a significant impact on the mental condition of the society, increasing anxiety and fear for the future. High levels of anxiety, stress and depression have been observed in the general population. Nurses and doctors, who are in direct contact with patients and their body fluids, are at the highest risk of infection. The aim of this study was to look at the psychiatric health aspects of health care professionals in general during the pandemic. State of knowledge: Work overload and stress-related symptoms make healthcare workers particularly vulnerable to mental distress, increasing the risk of developing mental disorders. Among them, women, students and nurses were most affected. A German study found that nurses working with COVID-19 patients in particular are mentally affected by the consequences of the pandemic. This may be due to the higher workload and the longer time spent in direct contact with COVID-19 patients compared to doctors. The available literature confirmed the construct of coronaphobia in health care workers. The issue of insufficient personalization of protective equipment and the associated feelings of fear and stigma as well as the need for psychological help are addressed and psychiatric services for healthcare professionals. Material and methods: At the beginning of this year, 30 people from the clinical hospital in Lublin were surveyed using a questionnaire containing several questions concerning, among others, comfort of work in the current epidemiological situation, The Patient Health Questionnaire-9, The Generalized Anxiety Disorder-7 and Mini-COPE. Conclusions: The work shows the mental health problems faced by health service representatives on a daily basis in connection with the pandemic that has been going on for many months. The features of depression-anxiety disorders affect the medical staff. The attitude of solidarity and cooperation of all members of society during the pandemic is important.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"198 1","pages":"151 - 181"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90464554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Anorexia nervosa (AN) is a mental disorder with the highest death rate. The characteristic feature of AN is endocrine dysregulations, including changes in adipose-tissue secreted hormones, especially adipokines. The most widely studied of them is leptin whose role in the pathophysiology and prognosis of AN is confirmed in more and more studies. The aim of the study was to summarize the role of endocrine disruptions with particular emphasis on leptin in the pathophysiology of AN. Material and methods: For the literature review, the electronic databases PubMed, Cochrane and Google Scholar search were used with the following keywords: eating disorders, adipokines, leptin, metreleptin, satiety, hunger, anorexia, obesity, for studies listed from database inception to October 2021. Results: Leptin, produced mainly by white adipose tissue, inhibits the hunger center in the hypothalamus by negative feedback with ghrelin secreted by the gastrointestinal tract. Leptin is involved in numerous biological functions, including body weight regulation, innate and adaptive immunity regulation, reproduction, and bone formation. Studies confirm decreased leptin levels in AN individuals. In recent years, extensive experience has been gained with leptin as a drug in clinical trials. The studies suggested that treatment can restore menstrual function and bone health and improve mood with unclear body weight effects. Conclusions: Focusing on leptin-related changes is a promising approach to improve AN management. Assessment of leptin levels in AN patients could be a useful tool for therapy monitoring. Treatment with leptin could reverse unfavourable changes induced by diet restriction, including mood symptoms, loss of bone mass and menstrual function. However, the results of these studies need confirmation on larger groups of patients.
{"title":"The role of leptin in patients recovering from Anorexia Nervosa","authors":"Zuzanna Rząd, J. Rog","doi":"10.2478/cpp-2021-0013","DOIUrl":"https://doi.org/10.2478/cpp-2021-0013","url":null,"abstract":"Abstract Introduction: Anorexia nervosa (AN) is a mental disorder with the highest death rate. The characteristic feature of AN is endocrine dysregulations, including changes in adipose-tissue secreted hormones, especially adipokines. The most widely studied of them is leptin whose role in the pathophysiology and prognosis of AN is confirmed in more and more studies. The aim of the study was to summarize the role of endocrine disruptions with particular emphasis on leptin in the pathophysiology of AN. Material and methods: For the literature review, the electronic databases PubMed, Cochrane and Google Scholar search were used with the following keywords: eating disorders, adipokines, leptin, metreleptin, satiety, hunger, anorexia, obesity, for studies listed from database inception to October 2021. Results: Leptin, produced mainly by white adipose tissue, inhibits the hunger center in the hypothalamus by negative feedback with ghrelin secreted by the gastrointestinal tract. Leptin is involved in numerous biological functions, including body weight regulation, innate and adaptive immunity regulation, reproduction, and bone formation. Studies confirm decreased leptin levels in AN individuals. In recent years, extensive experience has been gained with leptin as a drug in clinical trials. The studies suggested that treatment can restore menstrual function and bone health and improve mood with unclear body weight effects. Conclusions: Focusing on leptin-related changes is a promising approach to improve AN management. Assessment of leptin levels in AN patients could be a useful tool for therapy monitoring. Treatment with leptin could reverse unfavourable changes induced by diet restriction, including mood symptoms, loss of bone mass and menstrual function. However, the results of these studies need confirmation on larger groups of patients.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"39 1","pages":"182 - 186"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90439399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paweł Stanicki, Konrad Goliszek, Karol Kasprzak, A. Makarewicz
Abstract Introduction: It is estimated that various types of abnormalities from the autistic spectrum disorder occur in up to 2% of the population. These include difficulties in maintaining relationships, communication, and repetitive behaviours. Literature describes them quite well, in contrast to the causes of these disorders, which include both environmental factors and a very long list of genetic aberrations. Materials and methods: The papers available on the PubMed platform and other sources were reviewed to describe the most important genetic factors responsible for the development of autism spectrum disorders. Results: There are many genes and their mutations associated with the prevalence of autism spectrum disorders in patients. One of the main factors is the SHANK gene family, with the type and degree of abnormality in patients depending on the damage to particular genes: SHANK1-SHANK3. Research also shows the potential of targeted symptom-relieving therapies in patients with SHANK3 mutations. A correlation with the occurrence of autism has also been demonstrated for genes responsible for calcium signaling - especially the group of IP3R calcium channels. Their calcium transmission is abnormal in the majority of patients with autism spectrum disorders. A number of mutations in the 7q region were discovered - including the AUTS2, GNAI1, RELN, KMT2E, BRAF genes - the occurrence of which is associated with the presence of symptoms of autism. Autism spectrum disorders occur in about 10% of patients suffering from monogenic syndromes such as fragile X chromosome syndrome, Timothy syndrome, tuberous sclerosis, Rett syndrome or hamartomatic tumor syndrome. Conclusions: Research shows that many mutations can contribute to the development of autism spectrum disorders. Further studies are necessary to discover their therapeutic and diagnostic potential for autism.
{"title":"Genetic determinants of autism spectrum disorders - a review","authors":"Paweł Stanicki, Konrad Goliszek, Karol Kasprzak, A. Makarewicz","doi":"10.2478/cpp-2021-0011","DOIUrl":"https://doi.org/10.2478/cpp-2021-0011","url":null,"abstract":"Abstract Introduction: It is estimated that various types of abnormalities from the autistic spectrum disorder occur in up to 2% of the population. These include difficulties in maintaining relationships, communication, and repetitive behaviours. Literature describes them quite well, in contrast to the causes of these disorders, which include both environmental factors and a very long list of genetic aberrations. Materials and methods: The papers available on the PubMed platform and other sources were reviewed to describe the most important genetic factors responsible for the development of autism spectrum disorders. Results: There are many genes and their mutations associated with the prevalence of autism spectrum disorders in patients. One of the main factors is the SHANK gene family, with the type and degree of abnormality in patients depending on the damage to particular genes: SHANK1-SHANK3. Research also shows the potential of targeted symptom-relieving therapies in patients with SHANK3 mutations. A correlation with the occurrence of autism has also been demonstrated for genes responsible for calcium signaling - especially the group of IP3R calcium channels. Their calcium transmission is abnormal in the majority of patients with autism spectrum disorders. A number of mutations in the 7q region were discovered - including the AUTS2, GNAI1, RELN, KMT2E, BRAF genes - the occurrence of which is associated with the presence of symptoms of autism. Autism spectrum disorders occur in about 10% of patients suffering from monogenic syndromes such as fragile X chromosome syndrome, Timothy syndrome, tuberous sclerosis, Rett syndrome or hamartomatic tumor syndrome. Conclusions: Research shows that many mutations can contribute to the development of autism spectrum disorders. Further studies are necessary to discover their therapeutic and diagnostic potential for autism.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"261 1","pages":"139 - 150"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75100003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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