K. Karakuła, Aleksander Ryczkowski, E. Sitarz, Jacek Januszewski, D. Juchnowicz
Abstract Introduction: Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. Its prevalence tends to increase worldwide. Untreated sleep apnea is associated with a higher risk of metabolic diseases, cardiovascular diseases, stroke, road accidents, and death, but also it is suggested that it increases the risk of mental disorders. Method: The literature review was based on a search of articles on Medline, Pubmed, and Google Scholar from 2003 to 2021 using the keywords: obstructive sleep apnea; mental disorders; cognitive functions; affective disorders; depression; bipolar disorder; schizophrenia; psychotic disorders. The analysis included original studies, meta-analysis, and review articles. Discussion: The result obtained from researches published so far does not allow for drawing unequivocal conclusions. There is a lot of bias present in study protocols and inclusion/exclusion criteria. Nonetheless, it seems that some disorders have a better proven correlation with OSA. Cognitive impairment, depression, and anxiety disorders are linked to OSA not only in terms of the overlapping of symptoms but also of a causal relationship. Psychotic disorders and bipolar disorders connections with OSA are confirmed, but they are not yet well understood. All correlations are found to be possibly bidirectional. Conclusion: 1. Multiple lines of evidence increasingly point towards a bidirectional connection between OSA and mental disorders, and the cause and effect relationship between these two groups of disorders requires further research. 2. Due to reports of an increased risk of OSA with antipsychotic drugs, caution should be exercised when initiating therapy with this type of drug in patients with known risk factors for it. 3. Screening for OSA in psychiatric patients should be introduced as OSA can increase cognitive impairment, affective, and psychotic symptoms.
{"title":"The relationships between obstructive sleep apnea and psychiatric disorders: a narrative review","authors":"K. Karakuła, Aleksander Ryczkowski, E. Sitarz, Jacek Januszewski, D. Juchnowicz","doi":"10.2478/cpp-2021-0005","DOIUrl":"https://doi.org/10.2478/cpp-2021-0005","url":null,"abstract":"Abstract Introduction: Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. Its prevalence tends to increase worldwide. Untreated sleep apnea is associated with a higher risk of metabolic diseases, cardiovascular diseases, stroke, road accidents, and death, but also it is suggested that it increases the risk of mental disorders. Method: The literature review was based on a search of articles on Medline, Pubmed, and Google Scholar from 2003 to 2021 using the keywords: obstructive sleep apnea; mental disorders; cognitive functions; affective disorders; depression; bipolar disorder; schizophrenia; psychotic disorders. The analysis included original studies, meta-analysis, and review articles. Discussion: The result obtained from researches published so far does not allow for drawing unequivocal conclusions. There is a lot of bias present in study protocols and inclusion/exclusion criteria. Nonetheless, it seems that some disorders have a better proven correlation with OSA. Cognitive impairment, depression, and anxiety disorders are linked to OSA not only in terms of the overlapping of symptoms but also of a causal relationship. Psychotic disorders and bipolar disorders connections with OSA are confirmed, but they are not yet well understood. All correlations are found to be possibly bidirectional. Conclusion: 1. Multiple lines of evidence increasingly point towards a bidirectional connection between OSA and mental disorders, and the cause and effect relationship between these two groups of disorders requires further research. 2. Due to reports of an increased risk of OSA with antipsychotic drugs, caution should be exercised when initiating therapy with this type of drug in patients with known risk factors for it. 3. Screening for OSA in psychiatric patients should be introduced as OSA can increase cognitive impairment, affective, and psychotic symptoms.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"66 1","pages":"46 - 53"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73869051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Nonspecific inflammatory bowel diseases include Crohn’s disease (CD) and ulcerative colitis (CU – colitis ulcerosa), which are chronic diseases characterized by periods of exacerbation and remission. Extraintestinal complications caused by the disease and the applied treatment, mainly steroid therapy, constitute a predisposition to infections and mental disorders such as depressive disorders with apathy, slowness of movement or agitation, and even manic syndromes. Aim and method: The aim of this study was to review the literature on the occurrence of primary and secondary mental disorders in the course of inflammatory bowel diseases. The literature in the Google Scholar database was reviewed using the following keywords: colitis ulcerosa, Crohn disease, depression, mental disorders, inflammatory bowel disease. The time descriptors 2011-2021 were also used. Conclusions: The review of epidemiological studies shows that the most common mental disorders in nonspecific inflammatory bowel diseases are anxiety and depression disorders. The effect of steroid therapy on the development of mental disorders is equally significant. Most of the available empirical data relating to corticosteroids confirm the correlation between the drugs and depressive symptoms, and other psychiatric effects, including mania and psychosis. Summary: As with most chronic diseases, the prevalence of anxiety and depression disorders is higher in nonspecific inflammatory bowel diseases than in the general population.
{"title":"Occurrence of mental disorders in nonspecific inflammatory bowel diseases: a primary or secondary problem in relation to the biological therapy used?","authors":"Mateusz Olesiak, E. Stelmach","doi":"10.2478/cpp-2020-0022","DOIUrl":"https://doi.org/10.2478/cpp-2020-0022","url":null,"abstract":"Abstract Introduction: Nonspecific inflammatory bowel diseases include Crohn’s disease (CD) and ulcerative colitis (CU – colitis ulcerosa), which are chronic diseases characterized by periods of exacerbation and remission. Extraintestinal complications caused by the disease and the applied treatment, mainly steroid therapy, constitute a predisposition to infections and mental disorders such as depressive disorders with apathy, slowness of movement or agitation, and even manic syndromes. Aim and method: The aim of this study was to review the literature on the occurrence of primary and secondary mental disorders in the course of inflammatory bowel diseases. The literature in the Google Scholar database was reviewed using the following keywords: colitis ulcerosa, Crohn disease, depression, mental disorders, inflammatory bowel disease. The time descriptors 2011-2021 were also used. Conclusions: The review of epidemiological studies shows that the most common mental disorders in nonspecific inflammatory bowel diseases are anxiety and depression disorders. The effect of steroid therapy on the development of mental disorders is equally significant. Most of the available empirical data relating to corticosteroids confirm the correlation between the drugs and depressive symptoms, and other psychiatric effects, including mania and psychosis. Summary: As with most chronic diseases, the prevalence of anxiety and depression disorders is higher in nonspecific inflammatory bowel diseases than in the general population.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"41 1","pages":"264 - 268"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85840378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Recurrent use of psychoactive substances, including alcohol, affects most patients. It is an expression of the chronicity of the disease process. Understanding the causes of this phenomenon is the key to searching for effective therapeutic strategies for this disease. The aim: Analysis of individual dimensions of personality traits in patients in the context of relapses. Material and method: The research was carried out on a group of 301 people addicted to psychoactive substances staying in an addiction therapy center in Lubuskie and Zachodniopomorskie voivodships in Poland. The subjects were divided into two groups. The first group consisted of addicts with reported one-time therapy. The second group consisted of addicts who received at least two treatments at an addiction therapy center. The personality dimension was measured using the NEO-FFI questionnaire and the STAI questionnaire. Results: The following percentages of neuroticism (NF NEUR) were marked in people addicted to psychoactive substances with a single stay in an inpatient treatment center: 8.55% with low intensity, 40.13% with moderate intensity and 51.32% with high intensity. On the other hand, in people addicted to psychoactive substances with multiple stays in an inpatient treatment center, the features of low-grade neuroticism were found to be 6.85%, 25.34% of moderate and 67.81% of high intensity (χ2 = 8.643, p = 0.013). Conclusions: A higher score on the Nervousness Scale of the Neo FFI inventory has a significant impact on the course of addiction and the occurrence of relapses.
摘要简介:反复使用精神活性物质,包括酒精,影响大多数患者。这是疾病过程的慢性表现。了解这种现象的原因是寻找有效治疗策略的关键。目的:分析复发患者人格特征的个体维度。材料与方法:本研究是在波兰Lubuskie和Zachodniopomorskie省的一个成瘾治疗中心对一组301名精神活性物质成瘾者进行的。受试者被分成两组。第一组是接受过一次性治疗的成瘾者。第二组由在成瘾治疗中心接受至少两次治疗的成瘾者组成。人格维度采用NEO-FFI问卷和STAI问卷进行测量。结果:单次住院治疗中心精神活性物质成瘾者神经质(NF NEUR)发生率为:低强度8.55%,中强度40.13%,高强度51.32%。而在多次住院治疗中心的精神活性物质成瘾人群中,轻度神经质的比例为6.85%,中度神经质的比例为25.34%,高度神经质的比例为67.81% (χ2 = 8.643, p = 0.013)。结论:Neo FFI量表神经质量表得分越高,对成瘾过程和复发的发生有显著影响。
{"title":"Measurement of the dimensions of personality traits in patients addicted to psychoactive substances in context of relapses","authors":"K. Chmielowiec, A. Boroń","doi":"10.2478/cpp-2020-0019","DOIUrl":"https://doi.org/10.2478/cpp-2020-0019","url":null,"abstract":"Abstract Introduction: Recurrent use of psychoactive substances, including alcohol, affects most patients. It is an expression of the chronicity of the disease process. Understanding the causes of this phenomenon is the key to searching for effective therapeutic strategies for this disease. The aim: Analysis of individual dimensions of personality traits in patients in the context of relapses. Material and method: The research was carried out on a group of 301 people addicted to psychoactive substances staying in an addiction therapy center in Lubuskie and Zachodniopomorskie voivodships in Poland. The subjects were divided into two groups. The first group consisted of addicts with reported one-time therapy. The second group consisted of addicts who received at least two treatments at an addiction therapy center. The personality dimension was measured using the NEO-FFI questionnaire and the STAI questionnaire. Results: The following percentages of neuroticism (NF NEUR) were marked in people addicted to psychoactive substances with a single stay in an inpatient treatment center: 8.55% with low intensity, 40.13% with moderate intensity and 51.32% with high intensity. On the other hand, in people addicted to psychoactive substances with multiple stays in an inpatient treatment center, the features of low-grade neuroticism were found to be 6.85%, 25.34% of moderate and 67.81% of high intensity (χ2 = 8.643, p = 0.013). Conclusions: A higher score on the Nervousness Scale of the Neo FFI inventory has a significant impact on the course of addiction and the occurrence of relapses.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"56 1","pages":"203 - 209"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80894787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Karakuła, Olga Padała, Aleksander Ryczkowski, Alicja Forma, D. Juchnowicz
Summary Introduction: There is an ongoing debate as to whether the use of selective serotonin reuptake inhibitors (SSRIs) by pregnant women increases the risk of developing autism spectrum disorders (ASD) in the offspring. Aim: The aim of the study was to 1) present, based on a case report, the potential factors that may affect the development of ASD in a child, 2) review the literature on the risk of ASD in the case of using SSRIs by a pregnant woman. Case report: The case report concerns a child of a 33-year-old patient, previously treated for an episode of depression at the age of 23. At the beginning of the 15th week of planned pregnancy, when she was 28 years old, sleep disturbances were observed. Over the next few weeks, she gradually developed a full-blown depressive syndrome which required the use of sertraline. The child was born through a natural delivery, a healthy boy, who was diagnosed with ASD at the age of 2.5 years, which was the trigger for the development of the third episode of depression in the patient. Conclusions: The results of the research indicate that SSRIs can penetrate the placental barrier, influencing the processes of serotoninergic transmission in the fetus, disrupting neurodevelopmental processes. On the other hand, a higher risk of ASD development in children of depressed mothers who do not use pharmacotherapy was confirmed, compared to the general population and in the case of the occurrence of depressive episodes in mother in the past and in relation to the male fetuses. The greater risk of ASD in children of mothers who take SSRIs may not only be associated with the medication itself but also with the presence of depression and the probable common genetic basis for both disorders. In each case, other risk factors for the development of ASD should also be taken into consideration, e.g. vitamin D3 deficiencies, unsaturated fatty acids, oxytocin levels, the presence of intestinal dysbiosis.
{"title":"Controversies involving the use of SSRIs during pregnancy and the increased risk of having a child with autism spectrum disorders – a case report and literature review","authors":"K. Karakuła, Olga Padała, Aleksander Ryczkowski, Alicja Forma, D. Juchnowicz","doi":"10.2478/cpp-2020-0023","DOIUrl":"https://doi.org/10.2478/cpp-2020-0023","url":null,"abstract":"Summary Introduction: There is an ongoing debate as to whether the use of selective serotonin reuptake inhibitors (SSRIs) by pregnant women increases the risk of developing autism spectrum disorders (ASD) in the offspring. Aim: The aim of the study was to 1) present, based on a case report, the potential factors that may affect the development of ASD in a child, 2) review the literature on the risk of ASD in the case of using SSRIs by a pregnant woman. Case report: The case report concerns a child of a 33-year-old patient, previously treated for an episode of depression at the age of 23. At the beginning of the 15th week of planned pregnancy, when she was 28 years old, sleep disturbances were observed. Over the next few weeks, she gradually developed a full-blown depressive syndrome which required the use of sertraline. The child was born through a natural delivery, a healthy boy, who was diagnosed with ASD at the age of 2.5 years, which was the trigger for the development of the third episode of depression in the patient. Conclusions: The results of the research indicate that SSRIs can penetrate the placental barrier, influencing the processes of serotoninergic transmission in the fetus, disrupting neurodevelopmental processes. On the other hand, a higher risk of ASD development in children of depressed mothers who do not use pharmacotherapy was confirmed, compared to the general population and in the case of the occurrence of depressive episodes in mother in the past and in relation to the male fetuses. The greater risk of ASD in children of mothers who take SSRIs may not only be associated with the medication itself but also with the presence of depression and the probable common genetic basis for both disorders. In each case, other risk factors for the development of ASD should also be taken into consideration, e.g. vitamin D3 deficiencies, unsaturated fatty acids, oxytocin levels, the presence of intestinal dysbiosis.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"31 1","pages":"269 - 287"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91391515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: The experience of trauma and stress in childhood and early adulthood can lead not only to immediate physical and psychological symptoms but also to long-term effects observed in later life. Aim and method: The objective of the following study was to search for the correlation between the occurrence of childhood trauma and its long-term outcome, that is alcohol dependence, and to review studies concerning the presence of certain personality traits in patients with such trauma experience and prognostic factors for treatment. The literature in the Google Scholar database was reviewed using the following keywords: childhood abuse, childhood trauma, alcohol addiction and alcohol use disorder. The time descriptors 2015-2021 were also used. Results: On the basis of the conducted studies, it has been found that the experience of extremely stressful situations at a young age is declared by a greater part of the examined patients with alcohol dependence syndrome. It was also noticed that the most significant and most frequently reported negative childhood experiences in patients with alcohol dependence syndrome are physical violence, parental separation or divorce, and mental illness of a family member. It was found that impulsivity, disorder, pessimism, fatigue and asthenia are some of the characteristics of this group of patients. Conclusions: It can be concluded that there is a significant correlation between the occurrence of traumatic events in childhood and the tendency to develop alcohol addiction in adulthood.
{"title":"Childhood trauma and the prevalence of alcohol dependence in adulthood","authors":"Karolina Kosecka, E. Stelmach","doi":"10.2478/cpp-2020-0024","DOIUrl":"https://doi.org/10.2478/cpp-2020-0024","url":null,"abstract":"Abstract Introduction: The experience of trauma and stress in childhood and early adulthood can lead not only to immediate physical and psychological symptoms but also to long-term effects observed in later life. Aim and method: The objective of the following study was to search for the correlation between the occurrence of childhood trauma and its long-term outcome, that is alcohol dependence, and to review studies concerning the presence of certain personality traits in patients with such trauma experience and prognostic factors for treatment. The literature in the Google Scholar database was reviewed using the following keywords: childhood abuse, childhood trauma, alcohol addiction and alcohol use disorder. The time descriptors 2015-2021 were also used. Results: On the basis of the conducted studies, it has been found that the experience of extremely stressful situations at a young age is declared by a greater part of the examined patients with alcohol dependence syndrome. It was also noticed that the most significant and most frequently reported negative childhood experiences in patients with alcohol dependence syndrome are physical violence, parental separation or divorce, and mental illness of a family member. It was found that impulsivity, disorder, pessimism, fatigue and asthenia are some of the characteristics of this group of patients. Conclusions: It can be concluded that there is a significant correlation between the occurrence of traumatic events in childhood and the tendency to develop alcohol addiction in adulthood.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"9 1","pages":"288 - 293"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78745449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: The interpretation of white space in the Rorschach test has not been clearly defined. The aim of my research was to analyze the psychological meanings that can be associated with using space in Rorschach test responses. I examined a sample of healthy individuals in order to establish the basic meanings that could serve as points of reference when interpreting ill people’s responses. Material and method: I personally examined 158 healthy subjects with the Rorschach test. The examination procedure and the way of coding and interpreting responses were based on John Exner’s Comprehensive System. I divided the sample into three groups: I (no S responses), II (one or two S responses), and I II (three or more S responses). Next, I distinguished subgroup V (four or more S responses). I analyzed the differences between the groups in terms of other variables obtained in the examination using the Rorschach test. These variables were associated with using the complexity of the presented stimuli and with organizing the stimulus field; they were also associated with the emotional sphere, social adjustment, and ways of coping with stress. Results: Group III differed from groups II and I in terms of nine variables, and differences regarding further four variables approached significance. Differences between group V and the remaining examinees were more marked and concerned 14 variables. Discussion: Examinees with more S responses were better at using the complexity of stimuli and organizing the stimulus field. A certain characteristic feature of their emotional sphere also manifested itself: these people experienced situational stress more strongly, colored their responses with aggression, and more frequently experienced loneliness and alienation; intellectualization turned out to be their typical defense mechanism. Conclusions: Based on the collected material, it can be concluded that responses are related to examinees’ creative potential. Collected from healthy individuals, the material may facilitate the interpretation of ill people’s responses, especially as such research has not been conducted in a Polish population before.
{"title":"White space interpretation in Hermann Rorschach’s inkblot test","authors":"A. Hunca-Bednarska","doi":"10.2478/cpp-2020-0021","DOIUrl":"https://doi.org/10.2478/cpp-2020-0021","url":null,"abstract":"Abstract Introduction: The interpretation of white space in the Rorschach test has not been clearly defined. The aim of my research was to analyze the psychological meanings that can be associated with using space in Rorschach test responses. I examined a sample of healthy individuals in order to establish the basic meanings that could serve as points of reference when interpreting ill people’s responses. Material and method: I personally examined 158 healthy subjects with the Rorschach test. The examination procedure and the way of coding and interpreting responses were based on John Exner’s Comprehensive System. I divided the sample into three groups: I (no S responses), II (one or two S responses), and I II (three or more S responses). Next, I distinguished subgroup V (four or more S responses). I analyzed the differences between the groups in terms of other variables obtained in the examination using the Rorschach test. These variables were associated with using the complexity of the presented stimuli and with organizing the stimulus field; they were also associated with the emotional sphere, social adjustment, and ways of coping with stress. Results: Group III differed from groups II and I in terms of nine variables, and differences regarding further four variables approached significance. Differences between group V and the remaining examinees were more marked and concerned 14 variables. Discussion: Examinees with more S responses were better at using the complexity of stimuli and organizing the stimulus field. A certain characteristic feature of their emotional sphere also manifested itself: these people experienced situational stress more strongly, colored their responses with aggression, and more frequently experienced loneliness and alienation; intellectualization turned out to be their typical defense mechanism. Conclusions: Based on the collected material, it can be concluded that responses are related to examinees’ creative potential. Collected from healthy individuals, the material may facilitate the interpretation of ill people’s responses, especially as such research has not been conducted in a Polish population before.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"50 1","pages":"238 - 263"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77623203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: Disorders in the field of reward system neurotransmission are mentioned as one of the most important causes of addiction. Genetic variation is assigned a special role. The literature on the subject mentions primarily the genes of dopamine neurotransmission: DAT (dopamine transporter), DRD2 (dopamine receptor D2), DRD4 (dopamine receptor D4). However, so far there are few literature reports on these genes in the context of innovators in addiction therapy. The aim: Analysis of the relationship between the variability of specific polymorphisms in the DRD2 (rs1799732), ANKK1 (rs1800497), DAT (rs28363170), DRD4 (exon 3 - VNTR) genes with the occurrence of relapses in people addicted to psychoactive substances. Material and methods: The research was carried out on a group of 301 people addicted to psychoactive substances staying in an addiction therapy center in Lubuskie and Zachodniopomorskie voivodships in Poland. The control group consisted of 301 people with no diagnosed addiction to psychoactive substances nor mental disorders. The study of polymorphisms DRD2 (rs 1799732), ANKK1 (rs1800497) was performed by real-time PCR method; whereas DAT (rs28363170), DRD4 (exon 3 - VNTR) was genotyped by PCR and the amplified products were visualized using ethidium bromide stained gel electrophoresis (3% agarose) and UV photography. Results: This study showed that in addicts genotype frequencies of the VNTR polymorphism in the third exon of human DRD4 were as follow: S/L in 33.55%, S/S - 63.12% and L/L 3.32%; while in the control group S/L - 32.56%, S/S - 58.8 % and L/L - 8.6% (χ2 = 7.617, p = 0.022). Significant differences in the frequency of DRD2 gene polymorphism rs1799732 were observed (frequency of alleles; χ2 = 5.48, p = 0.0192) and DRD4 VNTR polymorphism (χ2 = 7.687, p = 0.021) between the addicted to psychoactive substances who have a one-time stay in an inpatient treatment center and the control group.
摘要导读:奖赏系统神经传递障碍被认为是成瘾的最重要原因之一。遗传变异被赋予了一个特殊的角色。文献主要提到多巴胺神经传递的基因:DAT(多巴胺转运体)、DRD2(多巴胺受体D2)、DRD4(多巴胺受体D4)。然而,到目前为止,在成瘾治疗创新者的背景下,很少有关于这些基因的文献报道。目的:分析DRD2 (rs1799732)、ANKK1 (rs1800497)、DAT (rs28363170)、DRD4(外显子3 - VNTR)基因特异性多态性变异与精神活性物质依赖者复发的关系。材料和方法:本研究是在波兰Lubuskie和Zachodniopomorskie省的一个成瘾治疗中心对301名精神活性物质成瘾者进行的。对照组由301名没有被诊断为精神活性物质成瘾或精神障碍的人组成。采用实时荧光定量PCR法对DRD2 (rs1799732)、ANKK1 (rs1800497)进行多态性研究;DAT (rs28363170)、DRD4(外显子3 - VNTR)用PCR分型,扩增产物用溴化乙啶染色凝胶电泳(3%琼脂糖)和紫外照相观察。结果:成瘾者DRD4第3外显子VNTR多态性基因型频率分别为:S/L占33.55%、S/S - 63.12%和L/L占3.32%;对照组S/L为32.56%、S/S为58.8%、L/L为8.6% (χ2 = 7.617, p = 0.022)。DRD2基因多态性rs1799732的频率差异显著(等位基因频率;χ2 = 5.48, p = 0.0192)和DRD4 VNTR多态性(χ2 = 7.687, p = 0.021)在一次性住院治疗中心精神活性物质依赖者与对照组之间的差异。
{"title":"Association of DRD2 (rs 1799732), ANKK1 (rs1800497), DAT (rs28363170), DRD4 (exon 3 - VNTR) gene polymorphisms in the context of relapses in therapy.","authors":"Jolanta Chmielowiec, A. Boroń","doi":"10.2478/cpp-2020-0018","DOIUrl":"https://doi.org/10.2478/cpp-2020-0018","url":null,"abstract":"Abstract Introduction: Disorders in the field of reward system neurotransmission are mentioned as one of the most important causes of addiction. Genetic variation is assigned a special role. The literature on the subject mentions primarily the genes of dopamine neurotransmission: DAT (dopamine transporter), DRD2 (dopamine receptor D2), DRD4 (dopamine receptor D4). However, so far there are few literature reports on these genes in the context of innovators in addiction therapy. The aim: Analysis of the relationship between the variability of specific polymorphisms in the DRD2 (rs1799732), ANKK1 (rs1800497), DAT (rs28363170), DRD4 (exon 3 - VNTR) genes with the occurrence of relapses in people addicted to psychoactive substances. Material and methods: The research was carried out on a group of 301 people addicted to psychoactive substances staying in an addiction therapy center in Lubuskie and Zachodniopomorskie voivodships in Poland. The control group consisted of 301 people with no diagnosed addiction to psychoactive substances nor mental disorders. The study of polymorphisms DRD2 (rs 1799732), ANKK1 (rs1800497) was performed by real-time PCR method; whereas DAT (rs28363170), DRD4 (exon 3 - VNTR) was genotyped by PCR and the amplified products were visualized using ethidium bromide stained gel electrophoresis (3% agarose) and UV photography. Results: This study showed that in addicts genotype frequencies of the VNTR polymorphism in the third exon of human DRD4 were as follow: S/L in 33.55%, S/S - 63.12% and L/L 3.32%; while in the control group S/L - 32.56%, S/S - 58.8 % and L/L - 8.6% (χ2 = 7.617, p = 0.022). Significant differences in the frequency of DRD2 gene polymorphism rs1799732 were observed (frequency of alleles; χ2 = 5.48, p = 0.0192) and DRD4 VNTR polymorphism (χ2 = 7.687, p = 0.021) between the addicted to psychoactive substances who have a one-time stay in an inpatient treatment center and the control group.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"25 1","pages":"193 - 202"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82072043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction: There are numerous points of controversy over the psychological interpretation of the so-called S responses – namely, the interpretation of white space in the Rorschach test. The aim of my paper was to verify the position held by Charles P. Fonda, who claims that the meaning of S responses depends on the results of the test as a whole. Materials and methods: I have presented the responses of two young men and coded them according to the Comprehensive System developed by John E. Exner. I chose this way of processing data as the most precise, relatively well formalized, and detailed one. The two examinees gave an almost identical number of responses in the whole test and a similar number of S responses, similarly distributed across the cards of the test. Results: I assessed and compared the results of the two examinees in terms of the effectiveness of their cognitive processes, self-control ability, mental resources, social adjustment, and self-esteem. Finally, I looked closely at the contents of a few responses, as in my opinion they symbolically expressed the examinees’ basic problems. Discussion: I tried to avoid describing the examinees’ psyche in nosological terms and to focus on presenting the way in which they experienced the world, as well as on how this experience affected their behavior. Conclusions: I found that in Examinee 1 criticism towards other people may stem from an excessively idealistic attitude to the world and from the ensuing disappointments. Good cognitive functioning, resistance to stress, positive self-esteem, and the socialized emotional sphere make this man’s S responses a sign of creative engagement in the problems encountered rather than a sign of maladjustment. In the case of Examinee 2, S responses can be understood as defiance and a generalized attitude of negativism, which play the role of defense against the excessively complicated, not fully comprehensible, and inhospitable world; these responses may, in their turn, contribute to the intensification of problems and to an increase in maladjustment.
摘要引言:关于所谓的S反应的心理学解释,即罗夏测验中空白的解释,存在许多争议。我这篇论文的目的是验证Charles P. Fonda的观点,他认为S反应的意义取决于整个测试的结果。材料和方法:我给出了两个年轻人的回答,并根据约翰·e·埃克斯纳开发的综合系统对他们进行了编码。我选择这种方式来处理数据,因为它是最精确的,相对来说形式化的比较好,也比较详细的。两名考生在整个测试中给出的回答数量几乎相同,S的回答数量也差不多,在测试卡片上的分布也差不多。结果:对两名考生的认知过程有效性、自我控制能力有效性、心理资源有效性、社会适应有效性、自尊有效性进行了评估和比较。最后,我仔细研究了一些回答的内容,在我看来,它们象征性地表达了考生的基本问题。讨论:我尽量避免用病理性的术语来描述考生的心理,而把重点放在展示他们体验世界的方式,以及这种体验如何影响他们的行为上。结论:我发现考生1对他人的批评可能源于对世界过于理想主义的态度以及随之而来的失望。良好的认知功能,对压力的抵抗力,积极的自尊,以及社会化的情感领域,使得这个男人的S反应是对遇到的问题进行创造性参与的标志,而不是适应不良的标志。在考生2的情况下,S的反应可以理解为反抗和一种广义的否定态度,它对过于复杂、不完全理解和不友好的世界起着防御作用;这些反应反过来又可能加剧问题和增加不适应的情况。
{"title":"White space interpretation in Hermann Rorschach’s inkblot test: An analysis of two male examinees’ responses","authors":"A. Hunca-Bednarska","doi":"10.2478/cpp-2020-0020","DOIUrl":"https://doi.org/10.2478/cpp-2020-0020","url":null,"abstract":"Abstract Introduction: There are numerous points of controversy over the psychological interpretation of the so-called S responses – namely, the interpretation of white space in the Rorschach test. The aim of my paper was to verify the position held by Charles P. Fonda, who claims that the meaning of S responses depends on the results of the test as a whole. Materials and methods: I have presented the responses of two young men and coded them according to the Comprehensive System developed by John E. Exner. I chose this way of processing data as the most precise, relatively well formalized, and detailed one. The two examinees gave an almost identical number of responses in the whole test and a similar number of S responses, similarly distributed across the cards of the test. Results: I assessed and compared the results of the two examinees in terms of the effectiveness of their cognitive processes, self-control ability, mental resources, social adjustment, and self-esteem. Finally, I looked closely at the contents of a few responses, as in my opinion they symbolically expressed the examinees’ basic problems. Discussion: I tried to avoid describing the examinees’ psyche in nosological terms and to focus on presenting the way in which they experienced the world, as well as on how this experience affected their behavior. Conclusions: I found that in Examinee 1 criticism towards other people may stem from an excessively idealistic attitude to the world and from the ensuing disappointments. Good cognitive functioning, resistance to stress, positive self-esteem, and the socialized emotional sphere make this man’s S responses a sign of creative engagement in the problems encountered rather than a sign of maladjustment. In the case of Examinee 2, S responses can be understood as defiance and a generalized attitude of negativism, which play the role of defense against the excessively complicated, not fully comprehensible, and inhospitable world; these responses may, in their turn, contribute to the intensification of problems and to an increase in maladjustment.","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"14 1","pages":"210 - 237"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90196949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrating national and international research, and exploring country-specific factors contributing to work addiction; Commentary to “Workaholism – psychological and social determinants of work addiction”","authors":"P. Atroszko, Bartosz Atroszko","doi":"10.2478/cpp-2020-0017","DOIUrl":"https://doi.org/10.2478/cpp-2020-0017","url":null,"abstract":"","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"68 1","pages":"189 - 192"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78251574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Objective: The purpose of the study is to analyze and define the content, specifics, and procedures of social and psychological work with citizens who have expressed a desire to become mentors for orphans. Introduction: In Ukraine, there are more than 750 foundations of institutional care and upbringing of children, in which approximately 106,000 children live. Only 8% among them have the status of orphans and children deprived of parental care; the other 92% have parents, but due to some difficult life circumstances of parents or presence of special needs or disability in children, they cannot live or be brought up in the family. It means that 92% of children without the status of orphans or children deprived of parental care cannot be adopted or placed for living and upbringing to other forms of family placement (guardianship/care, foster family, family-type orphanage). Along with this, out of 8% of orphan children and children deprived of parental care, there are no opportunities to be accommodated in any family forms of upbringing the following children: teenagers and youngsters, brothers and sisters from families with many children, and children with disabilities. In such children, close emotional relationships with meaningful, constant adults, which is a vital necessity for their psycho-emotional development and well-being, have been lost or were not formed at all. Accordingly, the introduction of mentoring for orphans and children deprived of parental care who live in relevant institutions is motivated by the necessity to satisfy the need of every child in emotional support, assistance and protection by a significant, authoritative person, and friend. Methods: The study uses an experience which was gained during the realization of the project as the author-developer of the methodology of socio-psychological work with citizens and children concerning preparations for mentoring and training for both coordinators and mentors of the Mentoring Program in cooperation with specialists of the “One Hope” non-governmental organization; in the role of educator for the preparation of coordinators for the Mentoring Program implementation, as well as in the role of expert during the implementation of Mentoring Program by the community organization “One Hope” during the 2009-2016 period [1]. Also, authors participated in developing of the mentors preparing program over orphans and children deprived of parental care in order to receive approval at the state level. Results: Mentoring for orphans and children deprived of parental care residing in institutions has been implemented in Ukraine since 2009 by the “One Hope” (“Odna Nadia”) public organization in cooperation with the Kyiv City Children’s Service and the Kyiv City Center of Social Services for Families, Children and Young People. The project “One Hope” was launched in the city of Kyiv and the Kyiv region during 2009-2016. Since 2016, mentoring as an individual form of support and assistanc
{"title":"Mentoring as an individual form of preparing orphans for independent living in Ukraine","authors":"I. Udovenko, T. Melnychuk, J. Gorbaniuk","doi":"10.2478/cpp-2020-0016","DOIUrl":"https://doi.org/10.2478/cpp-2020-0016","url":null,"abstract":"Abstract Objective: The purpose of the study is to analyze and define the content, specifics, and procedures of social and psychological work with citizens who have expressed a desire to become mentors for orphans. Introduction: In Ukraine, there are more than 750 foundations of institutional care and upbringing of children, in which approximately 106,000 children live. Only 8% among them have the status of orphans and children deprived of parental care; the other 92% have parents, but due to some difficult life circumstances of parents or presence of special needs or disability in children, they cannot live or be brought up in the family. It means that 92% of children without the status of orphans or children deprived of parental care cannot be adopted or placed for living and upbringing to other forms of family placement (guardianship/care, foster family, family-type orphanage). Along with this, out of 8% of orphan children and children deprived of parental care, there are no opportunities to be accommodated in any family forms of upbringing the following children: teenagers and youngsters, brothers and sisters from families with many children, and children with disabilities. In such children, close emotional relationships with meaningful, constant adults, which is a vital necessity for their psycho-emotional development and well-being, have been lost or were not formed at all. Accordingly, the introduction of mentoring for orphans and children deprived of parental care who live in relevant institutions is motivated by the necessity to satisfy the need of every child in emotional support, assistance and protection by a significant, authoritative person, and friend. Methods: The study uses an experience which was gained during the realization of the project as the author-developer of the methodology of socio-psychological work with citizens and children concerning preparations for mentoring and training for both coordinators and mentors of the Mentoring Program in cooperation with specialists of the “One Hope” non-governmental organization; in the role of educator for the preparation of coordinators for the Mentoring Program implementation, as well as in the role of expert during the implementation of Mentoring Program by the community organization “One Hope” during the 2009-2016 period [1]. Also, authors participated in developing of the mentors preparing program over orphans and children deprived of parental care in order to receive approval at the state level. Results: Mentoring for orphans and children deprived of parental care residing in institutions has been implemented in Ukraine since 2009 by the “One Hope” (“Odna Nadia”) public organization in cooperation with the Kyiv City Children’s Service and the Kyiv City Center of Social Services for Families, Children and Young People. The project “One Hope” was launched in the city of Kyiv and the Kyiv region during 2009-2016. Since 2016, mentoring as an individual form of support and assistanc","PeriodicalId":56342,"journal":{"name":"Current Problems of Psychiatry","volume":"76 1","pages":"167 - 173"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76795861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}