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中国地球物理学会年刊最新文献

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Characterizing nitric oxide exchange dynamics during tidal breathing: theory 潮汐呼吸过程中一氧化氮交换动力学的表征:理论
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106499
P. Conderelli, S. George
Parametric characterization of nitric oxide (NO) gas exchange using a two-compartment model of the lungs is a potentially promising, non-invasive technique to characterize inflammatory lung diseases. Currently, this technique is limited to single breath maneuvers, including pre-expiratory breath-hold, which is cumbersome for children and individuals with compromised lung function. The current study extends the two-compartment model to parametric characterization of NO gas exchange from tidal breathing data. We assess the potential to estimate up to six flow-independent parameters, and study alternate breathing patterns by varying breathing frequency and inspiratory/expiratory flow rate ratio at constant alveolar ventilation rate. We identify three, easily characterized flow-independent parameters, which include maximum airway flux, steady state alveolar concentration, and airway volume (uncertainty <10%). Rapid inhalation followed by slow (long duration) exhalation facilitates estimates of all flow-independent parameters. Our results demonstrate the potential of parametric analysis of tidal breathing data to characterize NO pulmonary exchange.
使用肺双室模型对一氧化氮(NO)气体交换进行参数化表征是一种潜在的有前途的、非侵入性的表征炎症性肺部疾病的技术。目前,这项技术仅限于单次呼吸操作,包括呼气前屏气,这对儿童和肺功能受损的个人来说很麻烦。目前的研究将双室模型扩展到潮汐呼吸数据中NO气体交换的参数表征。我们评估了估计多达六个与流量无关的参数的潜力,并通过在恒定肺泡通气率下改变呼吸频率和吸气/呼气流量比来研究交替呼吸模式。我们确定了三个易于表征的与流量无关的参数,包括最大气道通量、稳态肺泡浓度和气道容积(不确定性<10%)。快速吸入后缓慢(长时间)呼出有助于估计所有与流量无关的参数。我们的结果证明了潮汐呼吸数据的参数分析在表征NO肺交换方面的潜力。
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引用次数: 0
Feeling the squeeze: does airway constriction stimulate the bronchial epithelium? 感觉挤压:气道收缩刺激支气管上皮吗?
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106487
D. Tschumperlin, J. Drazen
Bronchospasm is a frequent occurrence in the airways of asthmatics, and subjects the bronchial epithelium to compressive stress. We show here that compressive stresses similar to those occurring in vivo trigger human bronchial epithelial cells to release endothelin (ET) and transforming growth factor-/spl beta/2 (TGF-/spl beta/2). Compressive stress leads to an increase in the steady state level of mRNA for both ET-1 and ET-2, and to the release of TGF-/spl beta/2 from a pre-formed, cell-associated pool. We also show that ET-2 and TGF-/spl beta/2 stimulate fibrotic protein synthesis by human lung fibroblasts, and act synergistically in combination. Our results demonstrate that compressive stress elicits selective release of fibrotic mediators from bronchial epithelium, indicating that bronchospasm may contribute to the subepithelial fibrosis and airways remodeling that characterize asthma.
支气管痉挛是哮喘患者气道中常见的症状,使支气管上皮受到压迫。我们在这里表明,类似于体内发生的压缩应力会触发人支气管上皮细胞释放内皮素(ET)和转化生长因子-/spl β /2 (TGF-/spl β /2)。压缩应力导致ET-1和ET-2 mRNA稳态水平的增加,并导致TGF-/spl β /2从预先形成的细胞相关池中释放。我们还发现ET-2和TGF-/spl β /2刺激人肺成纤维细胞合成纤维化蛋白,并协同作用。我们的研究结果表明,压缩应激诱导支气管上皮选择性释放纤维化介质,表明支气管痉挛可能有助于哮喘特征的上皮下纤维化和气道重塑。
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引用次数: 1
Removing residual power-line interference using WHT adaptive filter 利用WHT自适应滤波器去除残余电力线干扰
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1134433
Bor-Shyh Lin, Bor-Shing Lin, Wan-Chi Lee, F. Chong, Yue-Der Lin
Power-line interference is a common phenomenom in low-frequency biophysical measurement. The usual way of solving this is the use of a fixed bandwidth in an analog or digital notch filter. However, these methods are not very suitable when the power-line interference frequency is non-stationary. In this paper, an effective adaptive filter (ADF) structure is proposed to minimize the residual power-line interference without loss of reality. In order to obtain a satisfactory and acceptable convergence performance, the Walsh-Hadamard (WHT) transform is used in the ADF. Throughout many clinical measurements, the result of this structure is effective in eliminating EMI/EMC interference. However, to overcome the continuous changing frequency of power-line interference and to obtain a better convergence rate, a transform domain adaptive filter (TDADF) is used. An ECG result is shown after removing the power-line interference and its FFT.
电力线干扰是低频生物物理测量中常见的现象。解决这个问题的通常方法是在模拟或数字陷波滤波器中使用固定带宽。但是,当电力线干扰频率不稳定时,这些方法就不太适用了。本文提出了一种有效的自适应滤波器结构,可以在不损失真实性的前提下使剩余电力线干扰最小化。为了获得满意且可接受的收敛性能,在ADF中使用了Walsh-Hadamard (WHT)变换。在许多临床测量中,这种结构的结果有效地消除了EMI/EMC干扰。但是,为了克服电力线干扰频率的连续变化并获得更好的收敛速率,采用了变换域自适应滤波器(TDADF)。去除电力线干扰及其FFT后的心电图结果。
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引用次数: 5
Oncologic applications of functional MRI 功能性MRI在肿瘤学上的应用
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106238
E. Jackson
Functional MRI (fMRI), in a broad sense, has many applications in oncology. In terms of functional task activation imaging, common applications are in image-guided surgical resections of lesions, and applications to non-surgical approaches, such as stereotactic radiation therapy, are currently being evaluated. In terms of functional imaging assessment of the microvascular environment, applications include improved non-invasive characterization of lesions and the ability to quantitatively assess the effects of novel therapeutic regimens on lesions and surrounding normal tissues. Other functional MR applications, such as MR spectroscopy and diffusion imaging techniques, also have found applications in oncology. In this symposium session, current clinical and translational research applications of fMRI in oncology will be briefly reviewed.
广义的功能磁共振成像(fMRI)在肿瘤学中有着广泛的应用。在功能任务激活成像方面,常见的应用是在图像引导下的病变手术切除,而非手术方法的应用,如立体定向放射治疗,目前正在评估中。在微血管环境的功能成像评估方面,应用包括改进病变的非侵入性表征和定量评估新治疗方案对病变和周围正常组织的影响的能力。其他功能性磁共振应用,如磁共振光谱和扩散成像技术,也在肿瘤学中得到了应用。本次研讨会将简要介绍功能磁共振成像在肿瘤学中的临床和转化研究应用。
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引用次数: 0
Imaging skin with polarized light 用偏振光成像皮肤
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053299
S. Jacques, J. Ramella-Roman, K. Lee
Pathology in skin often occurs in the superficial layers of the epidermis and invades the papillary dermis. Imaging with linearly polarized light allows selection of photons that have reflected from these superficial tissue layers and rejection of photons that have penetrated deeply into the reticular dermis. Consequently, the image contrast is concentrated in the superficial tissue layers where pathology arises and invasion occurs.
皮肤病理通常发生在表皮的浅层,并侵入乳头状真皮层。线偏振光成像允许选择从这些表面组织层反射的光子,并拒绝深入网状真皮层的光子。因此,图像对比度集中在病理发生和侵袭发生的浅表组织层。
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引用次数: 2
Motor control changes after three months gait training in individuals with incomplete spinal cord injury 不完全性脊髓损伤患者三个月步态训练后运动控制的改变
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053386
H. Lim, S. Holmes, W. McKay, K. Cho, A. Williams, E. Protas, A. Sherwood
Ten subjects diagnosed with a spinal cord injury participated in gait training. Six patients were ASIA C and four were ASIA D. Nine were trained using supported treadmill ambulation training (STAT), while one was trained conventionally. Each was trained for twenty minutes, five days per week for three months. Before training, patient motor control patterns were evaluated bilaterally from five major sites on a lower limb using a protocol named Brain Motor Control Assessment (BMCA). To make a simple comparison, only TA and TS muscle activation ratios during unilateral dorsiflexion of each side was compared in this paper. Results were compared with gait speed test results.
10名被诊断为脊髓损伤的受试者参加了步态训练。6名患者为ASIA C, 4名患者为ASIA d。9名患者采用支撑式跑步机行走训练(STAT)进行训练,1名患者采用常规训练。每个人训练20分钟,每周五天,持续三个月。在训练前,采用脑运动控制评估(BMCA)方案,从下肢的五个主要部位对患者的运动控制模式进行双侧评估。为了进行简单的比较,本文只比较了单侧背屈时TA和TS肌肉的激活比。结果与步态速度测试结果进行比较。
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引用次数: 0
A portable intelligent stretching device for treating spasticity and contracture with outcome evaluation 一种用于治疗痉挛和挛缩的便携式智能拉伸装置及效果评估
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053371
Li-Qun Zhang, S.G. Chung, A.F. Lin, E.M. van Rey, Z. Bai, T. Grant, E. Roth
A portable stretching device with intelligent control was developed to treat the spastic/contractured ankle of neurologically impaired patients and evaluate the outcome. The device stretched the ankle throughout the range of motion (ROM) to extreme dorsiflexion and plantar flexion until a specified peak resistance torque was reached with the stretching velocity controlled based on the resistance torque. Stretching velocity was adjusted constantly. It was slow at the joint extreme positions, making it possible to reach a larger ROM safely, and it was fast in the middle ROM so the majority of the treatment was spent in stretching the problematic extreme ROM. The ankle was held at the extreme position for a period of time to let stress relaxation occur before it was rotated back to the other extreme position. Furthermore, the device evaluated treatment outcome quantitatively in multiple aspects, including active and passive ROM, joint stiffness and viscous damping, and reflex excitability. Combined with ultrasonography, the device was used to evaluate changes in mechanical properties of the Achilles tendon-aponeurosis induced by the stretching. The intelligent stretching reduced spasticity and contracture, including increases passive and active ROMs, decreases in elastic stiffness and viscous damping, and increase in muscle force-generating capacity.
开发了一种具有智能控制的便携式拉伸装置,用于治疗神经功能受损患者的痉挛/收缩踝关节并评估其效果。该装置在整个活动范围(ROM)内拉伸踝关节至极端背屈和足底屈,直到达到指定的峰值阻力扭矩,拉伸速度根据阻力扭矩控制。拉伸速度不断调整。在关节极端位置缓慢,可以安全地到达更大的ROM,在中间ROM快速,所以大部分治疗都花在拉伸有问题的极端ROM上。脚踝在极端位置保持一段时间,让压力放松,然后再旋转回另一个极端位置。此外,该装置还从多个方面定量评估治疗效果,包括主动和被动ROM、关节刚度和粘性阻尼、反射兴奋性。结合超声检查,评估拉伸引起的跟腱-腱膜力学性能的变化。智能拉伸减少了痉挛和挛缩,包括增加被动和主动rom,降低弹性刚度和粘性阻尼,增加肌肉发力能力。
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引用次数: 3
Patient satisfaction with TeleHomeCare 患者对远程家庭护理的满意度
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053056
M. Veen, S. Finkelstein, S. Speedie, J. Lundgren
Home health care is facing many challenges as it attempts to provide high quality care for a growing population within a limited budget. We used telemedicine in home care to show that low-cost, standards-based videoconferencing and Internet access can provide home care without compromising outcome, quality of care and patient satisfaction. This study showed that fewer patients were discharged to a hospital or a nursing home when they had received telehome care. In addition, study patients using home monitoring equipment were more satisfied with the health care they received.
家庭保健面临着许多挑战,因为它试图在有限的预算内为不断增长的人口提供高质量的护理。我们在家庭护理中使用远程医疗,以表明低成本、基于标准的视频会议和互联网接入可以在不影响结果、护理质量和患者满意度的情况下提供家庭护理。这项研究表明,当接受远程家庭护理时,出院到医院或养老院的患者较少。此外,使用家庭监控设备的研究患者对他们获得的卫生保健服务更满意。
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引用次数: 6
Development of a virtual reality model of the normal female pelvic floor 正常女性骨盆底的虚拟现实模型的开发
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1053340
M.S. Damser, M. Parikh, M. Rasmussen, L. Brubaker, R. Evenhouse, C. Salomon, K. Sakamoto, Z. Ai
The anatomy of the pelvic floor is complex and difficult to visualize. Thus, a virtual reality (VR) model could be useful both for teaching and research. The aim of this project was to develop a static three-dimensional (3-D) VR model of the normal female pelvic floor. An asymptomatic nulliparous twenty-three year old female with no urinary incontinence symptoms underwent a high resolution pelvic floor magnetic resonance imaging (MRI) scan. Manual segmentation of selected pelvic floor structures were performed. 3-D models were then created and edited. The completed models were displayed on an ImmersaDesk VR system. Stereovision glasses were used to enhance the model while a receiver tracked head position. The VR models accurately displayed the anatomy of the female pelvic floor. A 3-D VR model of the female pelvic floor could be used to enhance our understanding of anatomy and physiology of this complex part of the body. It could be used as a tool for both teaching and research, promoting improved treatment of pelvic floor pathologies.
骨盆底的解剖结构复杂且难以可视化。因此,虚拟现实(VR)模型对教学和研究都很有用。这个项目的目的是开发一个正常女性骨盆底的静态三维(3-D) VR模型。一位无症状无产的23岁女性,无尿失禁症状,接受了高分辨率盆底磁共振成像(MRI)扫描。对选定的盆底结构进行手工分割。然后创建和编辑三维模型。完成的模型在ImmersaDesk VR系统上展示。立体视觉眼镜用于增强模型,同时接收器跟踪头部位置。虚拟现实模型准确地显示了女性骨盆底的解剖结构。女性骨盆底的3d虚拟现实模型可以用来增强我们对这一复杂身体部位的解剖学和生理学的理解。它可以作为教学和研究的工具,促进盆底病变的改善治疗。
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引用次数: 2
Towards portable flow cytometry: study on the use of air-sheath-based volume-efficient two-phase microfluidic systems 迈向便携式流式细胞术:基于空气护套的体积高效两相微流体系统的研究
Pub Date : 2002-12-01 DOI: 10.1109/IEMBS.2002.1106579
D. Huh, A. Tkaczyk, Hsien-Hung Wei, J. Grotberg, S. Takayama
Reports experimental studies on air-liquid two-phase stratified flows in polymeric microfluidic channels for volume-efficient and cost-effective flow cytometry. Different flow behaviors of liquid core streams sheathed by air flows were investigated by varying surface chemistry and geometry of poly(dimethylsiloxane) (PDMS) channels. Fluorescent beads and myoblast cells carried by stable liquid flows were analyzed by a digital photo-multiplier tube (PMT)-based optical detection system to analyze the number of particles in a sample.
报道了用于高效体积和低成本流式细胞术的聚合微流体通道中气液两相分层流动的实验研究。通过改变聚二甲基硅氧烷(PDMS)通道的表面化学和几何形状,研究了被空气包裹的液芯流的不同流动行为。采用基于数字光倍增管(PMT)的光学检测系统对稳定液体流动携带的荧光珠和成肌细胞进行分析,以分析样品中的颗粒数量。
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引用次数: 4
期刊
中国地球物理学会年刊
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