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2009 2nd International Conference on Biomedical Engineering and Informatics最新文献

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Intra-Specific Density Dependent Effect of a Host-Parasitoid Interaction Model 寄主-寄生蜂相互作用模型的种内密度依赖效应
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5302430
Hua Liu
In this paper, the effect of intra-specific competition of host in a host-parasitoid model is investigated qualitatively by computer simulation. Many forms of complex dynamic are observed, including quasi-periodic, Hopf bifurcation reversal, and attractors crises. Furthermore, we obtain that the density- dependent effect may be a stabilizing factor. When hosts intra- specific competition stronger, the parameter region for persistent and stable interaction increases. I. INTRODUCTION The size of a natural population varies constantly and the variations may be small or large; sometimes regular, but in most cases irregular (1)-(4), so the dynamics of natural populations are very complicated (5), (6). The research area dealing with the complexities in the population dynamic models is the central issue in population ecology. In particular, the pioneering work in this field was initiated by May (7), (8). Now, the theory of single-population dynamics is quite well understood compared with the dynamics of interacting populations. Scientists have focused on studying interspecific interaction of natural populations whose generations are non- overlapping that can be modeled by difference equations. Difference equations describe how the population evolves in discrete time-step and can produce a much richer set of dynamic patterns than those observed in continuous-time models (9). Scientists have established many mathematical models to explain the dynamic behaviors of these interactions. It is not easy to analyze its global stability by qualitative method since the intrinsic nonlinearity, so people often study the dynamic complexity of host-parasitoid model by computer simulation. For different parameters and initial conditions, we can iterate the difference equations for thousands time steps and analyze the time series of population size to elucidate the regularity and mechanisms that hidden behind the population dynamics. Recently, many authors have adopted computer simulation to investigate the complexities of discrete-time host-parasitoid models. Kaitala and Heino (10) reported the dynamic com- plexity of host-parasitoid interaction with immunized and non- immunized host. Kaitala Ylikarjula and Heino (11), Tang and Chen (12) showed that many forms of complex dynam- ics were observed in host-parasitoid interaction model with Holling-type functional response. Xu and Boyce (13) also demonstrated the dynamic complexity of a mutual interference host-parasitoid model. All these research relied on a Logistic growth function to analyze the dyanmics of the host-parasitoid interaction and obtained some intriguing results. However, all these research are not to account for the discrepancy between dynamics predicted from these mathematical models is usually very intrigued and the dynamic behavior of real data is much simpler. Since this obvious discrepancy, many ecologists refused to accept the predictions from the deterministic mathematical models and prefer to accep
本文通过计算机模拟定性地研究了寄主-拟寄主模型中寄主种内竞争的影响。观察到多种形式的复杂动力学,包括拟周期、Hopf分岔逆转和吸引子危机。此外,我们还得出密度相关效应可能是一个稳定因素。当宿主种内竞争增强时,持续稳定相互作用的参数区域增大。自然种群的规模不断变化,变化可大可小;有时是规则的,但大多数情况下是不规则的(1)-(4),因此自然种群的动态非常复杂(5),(6)。处理种群动态模型中的复杂性的研究领域是种群生态学的核心问题。特别是,这一领域的开创性工作是由May(7),(8)发起的。现在,与相互作用的种群动力学相比,单种群动力学理论已经得到了很好的理解。科学家们一直致力于研究世代不重叠的自然种群的种间相互作用,这种相互作用可以用差分方程来建模。差分方程描述了种群如何在离散时间步中进化,并且可以产生比连续时间模型中观察到的更丰富的动态模式(9)。科学家已经建立了许多数学模型来解释这些相互作用的动态行为。由于其固有的非线性,用定性方法分析其全局稳定性是不容易的,因此人们通常通过计算机模拟来研究宿主-寄生性模型的动态复杂性。对于不同的参数和初始条件,我们可以迭代差分方程数千个时间步,分析种群规模的时间序列,以阐明隐藏在种群动态背后的规律和机制。近年来,许多作者采用计算机模拟的方法来研究离散时间寄主-寄生物模型的复杂性。Kaitala和Heino(10)报道了宿主-寄生蜂与免疫和未免疫宿主相互作用的动态复杂性。Kaitala Ylikarjula和Heino (11), Tang和Chen(12)的研究表明,寄主-寄生蜂相互作用模型存在多种形式的复杂动力学,具有holling型功能响应。Xu和Boyce(13)也证明了相互干扰的宿主-寄生性模型的动态复杂性。这些研究都依靠Logistic生长函数来分析寄主-拟虫相互作用的动力学,并获得了一些有趣的结果。然而,所有这些研究都没有考虑到这些数学模型预测的动态之间的差异通常是非常好奇的,而实际数据的动态行为要简单得多。由于这种明显的差异,许多生态学家拒绝接受确定性数学模型的预测,而更愿意接受环境噪声作为主要驱动力。论文(14)的结论是Allee效应(一种种内相互作用)缓解了动态复杂性,增强了数学模型在种群探索中的实用性。本文将在文献(15)研究的基础上,广泛分析密度依赖的种群动态效应,如种内竞争。在下一节中,我们将首先提出宿主-寄生模型,并对所有参数和变量进行解释。然后,通过数值模拟对种群动态进行全面研究。最后,我们将对结果进行总结并进行简短的讨论。
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引用次数: 1
Optimized Routing Structure Based Skyline Query Algorithm in Wireless Sensor Network 基于优化路由结构的无线传感器网络Skyline查询算法
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305586
Zhongbo Wu, Min Wang, Lei Yuan, Hongxi Jiang
Skyline is an important query in many applications such as environment monitoring and industrial controlling. Lots of achievements of skyline query have been made in traditional database. But they can not be used directly to wireless sensor network. In this paper we study continuous skyline query in wireless sensor network and put forward an energy efficient algorithm named ORSSQ. ORSSQ sets up filters in sensor nodes based on optimized routing structure. Filters can prune the sample data that can not be the final skyline result to save energy and prolong network life. Experiments show that ORSSQ has good performance.
在环境监测和工业控制等许多应用中,Skyline是一个重要的查询。传统数据库在天际线查询方面取得了许多成果。但它们不能直接用于无线传感器网络。本文对无线传感器网络中的连续天际线查询进行了研究,提出了一种节能的ORSSQ算法。ORSSQ基于优化的路由结构在传感器节点上设置滤波器。过滤器可以对不能成为最终天际线结果的样本数据进行修剪,从而节省能源,延长网络寿命。实验表明,ORSSQ具有良好的性能。
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引用次数: 2
Visual Model Based C-Arm System Calibration and Image Correction 基于视觉模型的c臂系统标定与图像校正
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305685
Shaojie Lv, Cai Meng, F. Zhou, Bo Liu, Xiaojun Zhou
In traditional methods, the C-Arm system calibration was performed based on the result of C-Arm image correction. When correcting images, high-order polynomial was used to fit relating distorted pixels to ideal image pixel. However accurate ideal image could not be established easily, that heavily restricted the precision of correction. In this paper, a novel method is presented based on visual model which does not depend on ideal image and integrates correction and calibration as one process. In this method, the Tsai's calibration method is used to calculate the internal and external parameters of C-Arm system with markers in the center region of the image. Then, nonlinear optimization is applied to get more precise C-Arm imaging model with all markers. Finally, the distortion image is corrected using the distortion parameters of internal parameters. To verify this method, known distances between points are reconstructed and the experimental results show that the maximum error is less than 1mm.
在传统方法中,c臂系统的标定是基于c臂图像的校正结果进行的。在校正图像时,采用高阶多项式对相关畸变像素与理想图像像素进行拟合。然而,精确的理想图像不容易建立,严重制约了校正的精度。本文提出了一种不依赖于理想图像,将校正和定标作为一个过程进行整合的基于视觉模型的方法。在该方法中,使用Tsai的校准方法计算c臂系统的内部和外部参数,并在图像的中心区域进行标记。然后,采用非线性优化方法,得到包含所有标记的更精确的c臂成像模型。最后,利用内部参数的畸变参数对畸变图像进行校正。为了验证该方法,对已知的点间距离进行了重构,实验结果表明,该方法的最大误差小于1mm。
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引用次数: 6
Effects of Aging on Biomechanics Properties in Rabbit Eyes 衰老对兔眼生物力学特性的影响
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305760
Xiaojun Wang, Weiyi Chen, Chunsheng Liu, Yanjun Li, Lei Ma
In order to study the effects of aging on biomechanics properties, twenty rabbits with healthy eyes were divided into four groups including infancy (3 months), youth (5 months), midlife (18 months) and agedness (48 months). After measuring the central corneal thickness (CCT) and the intraocular pressure (IOP), the alteration of eye volume with intraocular pressure was determined of four different age groups. Then sclera strips were prepared for biomechanical properties measurement through uniaxial tension using an Instron 5544 test machine. Our results showed: The CCT of the infancy was lower than the agedness (p 0.05) in four groups for the creep rate of sclera in 30 minutes.
为了研究老化对眼力学性能的影响,将20只健康眼兔分为幼年(3个月)、青年(5个月)、中年(18个月)和老年(48个月)4组。通过测量角膜中央厚度(CCT)和眼压(IOP),测定4个不同年龄组的眼体积随眼压的变化情况。然后制备巩膜条,利用Instron 5544试验机进行单轴拉伸生物力学性能测量。结果显示:4组患儿在30分钟内巩膜蠕变速率的CCT均低于老年(p < 0.05)。
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引用次数: 3
Multiple X-Ray Beam Radiography for Detecting Dental Demineralization 多x射线束造影检测牙齿脱矿
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305027
Dong-Hyun Park, Young-Ho Park, Kyung-Sook Kim, Gi-Ja Lee, Hun-Kuk Park
The purpose of this study was to develop the radiographic technique for detecting the demineralization which is known as indication of dental caries. This technique was based on the comparing of multiple radiographs which was irradiated by multiple X-ray spectra. For the meaningful comparison, the multiple radiographs were reconstructed to the dosimetrically consistent images using a standard material. The difference of resulting images of same target with multiple spectra represents the difference of response of material as regards the spectra. Consequently, we have found about 10% of demineralization of dental hard tissues particularly in the proximal region through the analyzing of differences. Most intriguing thing in this investigation was that the method to analyze difference shows us to an anatomic structure of dental hard tissues even if absolute values of optical density were excluded during the procedures.
本研究的目的是发展用于检测脱矿的x线摄影技术,这被称为蛀牙的指征。该技术是建立在多个x射线光谱照射的多张照片比较的基础上的。为了进行有意义的比较,使用标准材料将多张x线片重建为剂量学上一致的图像。同一目标的多个光谱结果图像的差异表示材料对光谱的响应差异。因此,通过差异分析,我们发现约10%的牙硬组织脱矿,特别是在近端区域。在这项研究中最有趣的是,分析差异的方法向我们展示了牙齿硬组织的解剖结构,即使在过程中排除了光密度的绝对值。
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引用次数: 0
Classification Research on Syndromes of TCM Based on SVM 基于支持向量机的中医证候分类研究
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305418
Chunming Xia, Feng Deng, Yiqin Wang, Zhaoxia Xu, Guoping Liu, Jin Xu, Helge Gewiss
Syndrome is a unique TCM concept, which is an abstractive collection of symptoms and signs. Several modern algorithms have been applied to classify syndromes, but no satisfied results have been obtained because of the complexity of diagnosis procedure. Support vector machine (SVM) has been found to be very efficient to solve the classification problems, especially for binary classification with good generalization properties. In this paper, firstly patients’ clinic data of heart disease were preprocessed, then chose the optimal kernel function and used the cross-validation method to find the best parameters for SVM model, finally, the accuracy of testing different syndromes in accordance with pathology of heart disease was obtained. The results indicated that SVM was the best identifier with 81.08% accuracy on samples than the stepwise regression with 77.30% and the neural network with 73.72%. In addition, by comparing with four different kernel functions of SVM, radial basis function (RBF) was the best identifier than the others. Keywords-Syndrome; Traditional Chinese Medicine; Support Vector Machine
证是一个独特的中医概念,是症状和体征的抽象集合。目前已有几种现代算法应用于证候分类,但由于诊断过程复杂,结果并不理想。支持向量机(SVM)是解决分类问题的有效方法,特别是对于具有良好泛化特性的二值分类。本文首先对心脏病患者的临床数据进行预处理,然后选择最优核函数,利用交叉验证的方法寻找SVM模型的最佳参数,最后获得根据心脏病病理检测不同证候的准确率。结果表明,SVM对样本的识别准确率为81.08%,优于逐步回归的77.30%和神经网络的73.72%。此外,通过对比4种不同的支持向量机核函数,径向基函数(RBF)是最优的识别方法。Keywords-Syndrome;中医;支持向量机
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引用次数: 7
Combine Pathway Analysis with Random Forests to Hunting for Feature Genes 结合途径分析和随机森林寻找特征基因
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5301655
Hua Lin, Weiying Zheng, Dongguo Li, Jinwang Zhang, Lin Hui, Yan Yan, Jian Zhang, Liu Hong
In this paper, a method combining pathway analysis with random forests was provided. After the important pathways were discovered by computing the classification error rates of out-of-bag (OOB), the feature genes were also discovered according to these important pathways. The important pathways were recombined as the new gene sets and the classification error rates were recomputed by random forests algorithms. According to the rank and the frequency of feature genes, the important feature genes associated with disease were discovered. At each important pathway, the relativity of gene expression was also studied. The results showed that our method was available because the expressions of genes at the same pathway were approximate. Those genes selected by SAM software directly were not feature genes but noises. We also compared random forests with other machine learning methods and found that random forests classification error rates were the lowest. This method can provide biological insight into the study of microarray data. Keywordsrandom forest, KEGG, pathway analysis, Microarray
本文提出了一种途径分析与随机森林相结合的方法。在通过计算出袋外(OOB)分类错误率发现重要途径后,根据这些重要途径发现特征基因。将重要路径重组为新的基因集,并利用随机森林算法重新计算分类错误率。根据特征基因的排序和频率,发现与疾病相关的重要特征基因。在每个重要的通路上,还研究了基因表达的相关性。结果表明,该方法是可行的,因为在同一途径上的基因表达是近似的。由SAM软件直接选择的基因不是特征基因,而是噪声基因。我们还将随机森林与其他机器学习方法进行了比较,发现随机森林的分类错误率最低。这种方法可以为微阵列数据的研究提供生物学见解。关键词:随机森林;KEGG;通路分析
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引用次数: 0
Coefficient of Variation Based Analysis of Coherence Resonance in Hodgkin-Huxley Neuron Model 基于变异系数的霍奇金-赫胥黎神经元模型相干共振分析
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305366
Chunxiao Han, Jiang Wang, Wenye Guan, Bin Deng, Feng Dong
We study the nonlinear response of the Hodgkin- Huxley model without external periodic signal to Gaussian white noise (GWN) and Ornstein-Uhlenbeck noise (OUN) as synaptic current respectively near the saddle-node bifurcation of limit cycles. The coherence of the system, estimated from the Coefficient of Variation of interspike interval of membrane potentials and spike trains, is minimal at certain noise intensity, so that the coherence resonance occurs. When GWN is served as synaptic input, coherence resonance occurs when noise intensity is greater than a certain threshold; when OUN is served as synaptic input, coherence resonance only occurs only with a moderate diffusion coefficient: too large diffusion coefficient will not generate coherence resonance. These findings further our understanding of how neurons respond to different types of noises.
研究了无外部周期信号的Hodgkin- Huxley模型在极限环鞍节点分岔附近分别以高斯白噪声(GWN)和Ornstein-Uhlenbeck噪声(OUN)为突触电流时的非线性响应。根据膜电位和峰列峰间间隔的变异系数估计,在一定的噪声强度下,系统的相干性最小,从而发生相干共振。当GWN作为突触输入时,当噪声强度大于一定阈值时发生相干共振;当OUN作为突触输入时,只有扩散系数适中时才会发生相干共振,扩散系数过大时不会产生相干共振。这些发现进一步加深了我们对神经元如何对不同类型的噪音作出反应的理解。
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引用次数: 1
Scientific Quality Towards Specific Topics 面向特定主题的科学素质
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305784
Hao Wu, Yijian Pei
The studies of citations are comprehensively carried out with the increasing electronically citation data on the Web. Most of the metrics observe scientific quality in a global view instead of in multiple fine-grained views. In this paper, we suggest to apply Topic Model and adaptive PageRank algorithm to assess the relative importance of scientific objects including articles, authors, conferences and journals. The scientific quality is measured by an aggregation PageRank metric towards some topics. This metric considers the impact of a paper both in global view and local view. The experiments on ACL Anthology bibliographic corpus show our method is a useful measure to observe scientific quality on multi-views. KeywordsPageRank; Topic Model; Citation Analysis
随着网络上电子引文数据的不断增加,对引文的研究正在全面展开。大多数度量在全局视图中观察科学质量,而不是在多个细粒度视图中。在本文中,我们建议应用主题模型和自适应PageRank算法来评估科学对象的相对重要性,包括文章、作者、会议和期刊。科学质量是通过对某些主题的聚合PageRank度量来衡量的。这个指标考虑了一篇论文在全球和局部两方面的影响。在ACL文集书目语料上的实验表明,该方法是一种多角度观察科学质量的有效方法。KeywordsPageRank;主题模型;引文分析
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引用次数: 0
Three-Dimensional Reconstruction of Vessels from Intravascular Ultrasound Sequence and X-Ray Angiograms 从血管内超声序列和x线血管造影中重建血管
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305690
Sun Zheng
A method to reconstruct vessels from intravascular ultrasound (IVUS) image sequence and X-ray angiograms is proposed in this paper. The pullback path of IVUS catheter is tracked and reconstructed from angiographic image pair acquired during IVUS intervention. Cross-sectional borders of the vessel wall are detected from IVUS frames in a semi- automatic manner. After axial locations of IVUS frames are determined along the 3D pullback path of IVUS catheter, their spatial orientations are determined based on a Frenet-Serret frame model and global optimization. Finally, the vessel is accurately reconstructed with solid modeling technique. Experimental results with clinical data demonstrate the validity.
本文提出了一种利用血管内超声(IVUS)图像序列和x线血管图像重建血管的方法。根据IVUS介入过程中获得的血管造影图像对,对IVUS导管的回拉路径进行跟踪和重构。从IVUS框架以半自动的方式检测血管壁的横截面边界。IVUS框架沿IVUS导管三维回拉路径确定轴向位置后,根据Frenet-Serret框架模型和全局优化确定其空间方向。最后,利用实体建模技术对血管进行精确重构。实验结果与临床数据验证了该方法的有效性。
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引用次数: 6
期刊
2009 2nd International Conference on Biomedical Engineering and Informatics
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