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2009 2nd International Conference on Biomedical Engineering and Informatics最新文献

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Enhanced Cytotoxicity Suppression of Arsenic Trioxide to Leukemia Cancer Cells by Using Magnetic Nanoparticles 磁性纳米颗粒增强三氧化二砷对白血病细胞的细胞毒性抑制作用
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305763
Dadong Guo, Wenfeng Song, Xuemei Wang, Baoan Chen
Recently, superparamagnetic nanoparticles of iron oxides have shown great potential in bio-applications, including magnetic resonance imaging contrast enhancement, drug delivery, bio-separation, tissue repair, hyperthermia, and others. In this study, we have explored the enhanced cytotoxicity effect of arsenic trioxide (As2O3) on both sensitive K562 cell line and adriamycin-resistance K562/A02 cell line in the absence and presence of Fe3O4 nanoparticles by MTT assay. The results demonstrate that Fe3O4 nanoparticles could inhibit the function of Pglycoprotein (P-gp) so as to increase the relevant drug accumulation in target cancer cells and thus enhance the cytotoxicity suppression of As2O3. This raises the promising possibility of the great potential application of Fe3O4 nanoparticles in the cancer chemotherapy of leukemia in clinical area.
近年来,超顺磁性氧化铁纳米颗粒在磁共振成像对比度增强、药物传递、生物分离、组织修复、热疗等生物领域显示出巨大的应用潜力。在这项研究中,我们通过MTT实验探讨了三氧化二砷(As2O3)在没有和存在Fe3O4纳米粒子的情况下对敏感的K562细胞株和阿霉素抗性的K562/A02细胞株的增强细胞毒性作用。结果表明,Fe3O4纳米颗粒可以抑制p糖蛋白(P-gp)的功能,从而增加靶癌细胞中相关药物的积累,从而增强As2O3对细胞毒性的抑制作用。这为Fe3O4纳米颗粒在白血病肿瘤化疗中的临床应用提供了广阔的前景。
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引用次数: 2
Approximate Analytical Solution for Tissue Temperature Distribution in High-Intensity Focused Ultrasound 高强度聚焦超声中组织温度分布的近似解析解
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5304866
Dehui Li, G. Shen, Jingfeng Bai, Yazhu Chen
An approximate analytical solution for tissue temperature distribution in high-intensity focused ultrasound (HIFU) is obtained in this work. Based on variable separation method (VSM), the solution is performed to solve the simplified bioheat transfer equation (BHTE). Lack of enough boundary conditions; the parameters in this analytic solution are estimated using the temperature data calculated by finite element method (FEM) with nonlinear least square algorithm. The absolute root mean square error (RMSE) of temperature is 0.21℃ and 0.22℃ for two strategies, respectively. Feasibility and accuracy of the analytical solution are verified by comparison with FEM for transient temperature response in a longer time domain. The average deviation of temperature is about 0.35℃. So this analytic solution is suitable to calculate spatiotemporal temperature distribution in HIFU treatment, and it is quite useful to the treatment planning.
本文给出了高强度聚焦超声(HIFU)中组织温度分布的近似解析解。基于变量分离法(VSM),求解简化生物传热方程(BHTE)。缺乏足够的边界条件;利用非线性最小二乘有限元法计算的温度数据对解析解中的参数进行了估计。两种策略的温度绝对均方根误差(RMSE)分别为0.21℃和0.22℃。通过与有限元法在较长时域内瞬态温度响应的比较,验证了解析解的可行性和准确性。温度平均偏差约为0.35℃。因此,该解析解适用于HIFU治疗过程中温度的时空分布计算,对治疗方案的制定有一定的参考价值。
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引用次数: 1
A Robust Medical Image Registration Algorithm Based on the SAM of Multi-Scale Harris Corners 基于多尺度Harris角点SAM的鲁棒医学图像配准算法
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5302680
Ying Ding, Jingtao Fan, Huamin Yang
To make up for the lack of concern on spatial information in conventional mutual information based image registration framework, this paper designs a novel registration algorithm based on the SAM information of multi-scale Harris corners (CSAM for short). First, the multi-scale contour is extracted, and multi-scale Harris corner detector is added to acquire the estimated transform parameters; and then CSAM is regarded as Similarity Measure function, several optimized match points are obtained, the finally registration parameters are resolved by using least squares method. This algorithm realizes registration of medical images with noise and multiresolutions, further more, it only matches corners and doesn’t need optimal searching, so it has reduced calculate time and avoided local extremum. Experimental results on clinical CT and T1-weighted MR images demonstrate that, as compared with the conventional mutual information based method, the proposed method consistently completes much higher precision, faster speed and better robustness. Keywords-image registration; square root arithmetic mean divergence(SAM); Harris corner; multi-scale
针对传统基于互信息的图像配准框架对空间信息关注不足的问题,本文设计了一种基于多尺度Harris角点SAM信息的图像配准算法。首先提取多尺度轮廓,加入多尺度Harris角点检测器获取估计的变换参数;然后将CSAM作为相似度度量函数,得到多个优化匹配点,最后利用最小二乘法求解配准参数。该算法实现了具有噪声和多分辨率的医学图像配准,并且只匹配角点,不需要最优搜索,减少了计算时间,避免了局部极值。在临床CT和t1加权MR图像上的实验结果表明,与传统的基于互信息的方法相比,本文方法具有更高的精度、更快的速度和更好的鲁棒性。Keywords-image登记;平方根算术平均散度;哈里斯角落;多尺度
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引用次数: 2
Wrist Pulse Analysis Based on RP and RQA 基于RP和RQA的腕部脉搏分析
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305193
Chunming Xia, Rui Liu, Yiqin Wang, Haixia Yan, Helge Gewiss
Wrist pulse waveform analysis is common in Traditional Chinese Medicine (TCM) engineering and diagnosis modernization. Nonlinear dynamics theory has been a tool in the analysis of physiological signals containing some nonlinear and chaotic information indispensable. The chaotic properties of wrist pulse containing a wealth of human physiological and pathological information were seldom studied. An application of nonlinear qualitative and quantitative analysis method, i.e., Recurrence Plots (RP) and Recurrence Quantification Analysis(RQA), to analyze the two kinds of wrist pulse time series is proposed in this paper. Both controls and patients with cardiovascular diseases, and the other kind of series of 4 common TCM pulses are analyzed by RP and RQA to extract nonlinear features, which are then used for classification and discrimination. The results from analyzing real data show the feasibility of the proposed RP and RQA method and indicate the potential of further applications to syndrome classification and diagnosis. Keywords-wrist pulse analysis, nonlinear features, syndrome classification, Recurrence Plots (RP), Recurrence Quantification Analysis(RQA)
腕部脉搏波形分析在中医工程和中医诊断现代化中十分常见。非线性动力学理论已经成为分析生理信号中所包含的一些不可缺少的非线性和混沌信息的工具。腕部脉搏的混沌特性包含着丰富的人体生理和病理信息,但研究很少。本文提出了一种非线性定性和定量分析方法,即递归图(recurrent Plots, RP)和递归量化分析(recurrent Quantification analysis, RQA),来分析两种腕部脉冲时间序列。采用RP和RQA对对照组、心血管病患者和其他4种常见中医脉冲序列进行分析,提取非线性特征,并将非线性特征用于分类和判别。实际数据分析结果表明,所提出的RP和RQA方法是可行的,并显示了在证候分类和诊断中进一步应用的潜力。关键词:腕部脉搏分析,非线性特征,证候分类,复发图(RP),复发量化分析(RQA)
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引用次数: 5
The Effects of Chitosan-Hyaluronic Acid Blended Membrane on the Growth of Keratocytes 壳聚糖-透明质酸混合膜对角质细胞生长的影响
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305837
Zi-Ang Yao, Hai-Ge Wu, Ying Bai, Wei Qu, Yan Pan
In order to construct a suitable scaffold for corneal cells culture and transplantation in vitro, different chitosan- hyaluronic acid blended membranes were prepared and the compatibility of chitosan and hyaluronic acid in blended membranes was studied. Rabbit keratocytes were seeded onto the blended membranes surface and the effects of the blended membranes on cells attachment and metabolism were investigated. The results showed that chitosan and hyaluronic acid had good compatibility in blended membranes within a certain blended ratio. Within the blending ratio of 1:0.05, hyaluronic acid could reduce the damage of chitosan membrane to cells and improve the adhersion and proliferation of cells on blended membranes. So chitosan and hyaluronic acid had good compatibility within a certain blended ratio. Hyaluronic acid could improve the biocompatibility between cells and membranes. The blended membrane had potential to be used as a scaffold for corneal cells culture in vitro and a carrier for corneal cells transplantation. Keywords-chitosan; hyaluronic acid; blended membrane; keratocytes
为了构建适合角膜细胞体外培养和移植的支架,制备了不同的壳聚糖-透明质酸混合膜,并研究了壳聚糖与透明质酸在混合膜中的相容性。将兔角质细胞植入混合膜表面,观察混合膜对细胞附着和代谢的影响。结果表明,壳聚糖与透明质酸在一定配比下,在共混膜中具有良好的相容性。在1:0.05的混合比例下,透明质酸可以降低壳聚糖膜对细胞的损伤,提高细胞在混合膜上的粘附和增殖能力。说明壳聚糖与透明质酸在一定配比下具有良好的相容性。透明质酸能改善细胞膜间的生物相容性。混合膜可作为角膜细胞体外培养的支架和角膜细胞移植的载体。Keywords-chitosan;透明质酸;混合膜;可见
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引用次数: 0
Design and Implementation of Computer Assisted Thoracic Surgery System 计算机辅助胸外科手术系统的设计与实现
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5304944
Yanmin Peng, Rong Liu
The system chose the Visualization Toolkit and Visual C++ as the development platform. The coronal section and the sagittal section were reconstructed through the crosssection of patients thoracic computed tomography (CT). Analyzing of these slices, the doctor can discover the position of tumors. And then the three-dimensional (3-D) reconstruction of the chest and the tumors can be reconstructed by the volume rendering Ray-Casting method. The position of incision surgery can be located by the position of tumors, which would help the doctor analysis and view tumors and 3-D reconstruction of the chest from any angle through graphical visual interfaces in the computer. The surgical injury could be minimized.
本系统选用visualtoolkit和Visual c++作为开发平台。通过患者胸部计算机断层扫描(CT)横切面重建冠状面和矢状面。通过分析这些切片,医生可以发现肿瘤的位置。然后利用体绘制射线投射法对胸部和肿瘤进行三维重建。通过肿瘤的位置定位切口手术的位置,帮助医生通过计算机的图形化可视化界面,从任何角度分析和观察肿瘤,并对胸部进行三维重建。可以将手术损伤降到最低。
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引用次数: 0
Chaotic Synchronization of Coupled Hindmarsh-Rose Neurons Using Adaptive Control 基于自适应控制的耦合Hindmarsh-Rose神经元混沌同步
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5302804
Yu Shi, Jiang Wang, Bin Deng, Qiuxiang Liu
In this paper, we propose an approach for adaptive synchronization of two uncertain nonlinear chaotic neuron systems by using the coupled system of Hindmarsh-Rose [18]. An outline of this paper is given as follows: In Sec. 2, we study the dynamics of gap junction coupled neuronal system of two HR neurons without control. In Sec.3, we design the adaptive controller for chaos synchronization of the coupled HR neurons. Asymptotic synchronization can be obtained by proper choice of the control parameters. The simulation given in Sec. 4 demonstrated the effectiveness of the control. Conclusion of this paper is given in Sec. 5.
本文提出了一种利用Hindmarsh-Rose耦合系统实现两个不确定非线性混沌神经元系统自适应同步的方法[18]。在第二节中,我们研究了两个无控制的HR神经元的间隙连接耦合神经元系统的动力学。在第3节中,我们设计了用于耦合HR神经元混沌同步的自适应控制器。通过合理选择控制参数,可以实现渐近同步。第4节给出的仿真证明了控制的有效性。第五节给出了本文的结论。
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引用次数: 11
A Novel Method for Computer Aided Plastic Surgery Prediction 一种计算机辅助整形手术预测的新方法
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305021
Jie Liu, Xubo Yang, T. Xi, Lixu Gu, Zhe-yuan Yu
In this paper, a novel method based on former cases for plastic surgery prediction is presented. This method takes a pre-operative frontal facial picture as an input. Landmarks of the face are then extracted and constitute a distance vector. As a set of facial parameters, such a vector is entered into either a sup- port vector regression (SVR) predictor or a k-nearest neighbor (KNN) predictor which is trained on a set of pre- and post- operative facial distance vectors of former cases. After the pre- dicted distance vector generated, new landmarks positions are updated and the final result is generated in terms of changes be- tween predicted landmarks and the original ones. Several expe- riments are carried out and the results show a great accuracy of prediction, which proves that this method is of high validity. Keywords-ASM; SVR; KNN; plastic surgery prediction
本文提出了一种基于以往案例的整形手术预测新方法。该方法以术前额部面部图像作为输入。然后提取人脸的地标并构成距离向量。作为一组面部参数,该向量被输入支持向量回归(SVR)预测器或k近邻(KNN)预测器,该预测器在术前和术后病例的面部距离向量集上进行训练。在生成预测距离向量后,更新新的地标位置,并根据预测地标与原始地标之间的变化生成最终结果。实验结果表明,该方法具有较高的预测精度,具有较高的有效性。Keywords-ASM;SVR;资讯;整形手术预测
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引用次数: 9
Efficient Privacy of Message Encryption Algorithm for Anonymous Receivers in E-Commerce 电子商务中匿名接收者消息加密算法的高效保密性
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305827
Xiangyang Xu
protecting the privacy of message receivers is an important issue in pay services of e-commerce and the distribution of digital contents on the Internet. This paper proposes an efficient privacy of message encryption algorithm called PMEA for pay services of e-commerce. In PMEA, each of the receivers only needs to perform constant times of pairing computation to decrypt the received message. PMEA adopts bilinear pairings on elliptic curves to protect the privacy of message receivers, to ensure that an attacker or any other message receiver can not derive the identity of a message receiver such that the privacy of every receiver can be guaranteed. Detailed theoretical analysis proves that PMEA is secure and anonymous for message receivers. Keywordsprivacy message; encryption algorithm; anonymous receivers; E-commerce
信息接收者的隐私保护是电子商务支付服务和互联网数字内容分发中的一个重要问题。针对电子商务支付服务,提出了一种高效的消息隐私加密算法PMEA。在PMEA中,每个接收方只需要执行一定次数的配对计算来解密接收到的消息。PMEA采用椭圆曲线上的双线性对来保护消息接收者的隐私,保证攻击者或任何其他消息接收者无法推导出消息接收者的身份,从而保证每个消息接收者的隐私。详细的理论分析证明了PMEA对消息接收方具有安全性和匿名性。Keywordsprivacy消息;加密算法;匿名接收器;电子商务
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引用次数: 1
Sequence Analysis of rDNA ITS of Clinical Fusarium Species 临床镰刀菌rDNA ITS序列分析
Pub Date : 2009-10-30 DOI: 10.1109/BMEI.2009.5305743
He Li, G. Zhou, Junang Liu
The study on molecular structure of Fusarium proliferatum clinically isolated can provide the basis for accurate diagnosis and treatment of F. proliferatum infection. The rDNA ITS gene of 6 strains that had been identified as Fusarium proliferatum based on morphological were cloned and sequenced. The molecule phylogenetic tree was constructed based on rDNA ITS sequences, and the 6 genus were divided into two groups. Group was F.proliferatum, including strains of CSUFT201, CSUFT204, CSUFT205. Group was F. moniliforme, including CSUFT202,CSUFT203,CSUFT206. The results of this study showed that 3 strains of F. moniliforme were confirmed out of the 6 strains with the molecular methods. Keywords-Fusarium; ITS gene; clone; phylogenetic; sequence analysis
对临床分离的增肉镰刀菌分子结构的研究可为增肉镰刀菌感染的准确诊断和治疗提供依据。对经形态学鉴定为增殖镰刀菌的6株菌株的rDNA ITS基因进行了克隆和测序。基于rDNA ITS序列构建分子系统进化树,将6个属划分为2个类群。组为增殖假体,包括CSUFT201、CSUFT204、CSUFT205菌株。组为念珠菌,包括CSUFT202、CSUFT203、CSUFT206。本研究结果表明,6株念珠菌中有3株经分子方法鉴定为念珠菌。Keywords-Fusarium;它的基因;克隆;系统发育;序列分析
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引用次数: 0
期刊
2009 2nd International Conference on Biomedical Engineering and Informatics
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