Journal of Leather Science and Engineering最新文献_第2页

Porous surface coating fabrication for polyurethane synthetic leather: a review 聚氨酯合成革多孔表面涂层制备研究进展

Journal of Leather Science and Engineering

Pub Date : 2025-11-05 DOI: 10.1186/s42825-025-00219-4

Zhenghao Shi, Man-Hin Kwok, To Ngai

The use of leather in human history spans thousands of years, and the mass production of leather techniques also has a longstanding history over a century. The emergence of synthetic leather arose as a response to the market’s demand for an alternative due to a shortage of natural leather supply. However, the ongoing challenge of environmental pollution during the continuous development of synthetic leather to achieve comparable features to its natural counterparts has led the leather industry to deviate from its original goal of sustainability and environmentally friendliness, focused on “waste to worth” principle. Following the replacement of polyvinyl chloride (PVC) with polyurethane (PU) as the primary material for the surface layer in synthetic leather, waterborne polyurethane (WPU) and solvent-free polyurethane (SFPU) emerged as the principal environmentally friendly raw material for synthetic leather manufacturing. The free volume (FV) theory explains the relation between mass transfer in polymer films and increasing FV in polymer coatings, highlighting its benefit to water vapor permeability (WVP). The WVP of a synthetic leather is primarily influenced by the hydrophilicity and porous structure of the polymer coating, determined by the base fabrics and the raw polymer coating material. This paper reviews various methods for preparing porous structures to increase WVP of polymer films or coatings: chemical blowing, thermally expandable microspheres, laser drilling, hollow microspheres, surfactant-stabilized foam templates and Pickering aqueous foam templates. It also provides a concise outline of present issues and prospects in improving the breathability of synthetic leather derived from these approaches.

Graphical Abstract

人类历史上对皮革的使用跨越了数千年，皮革技术的大规模生产也有一个多世纪的悠久历史。由于天然皮革供应短缺，市场对替代品的需求引起了合成革的出现。然而，在不断发展合成革以达到与天然皮革相当的特性的过程中，环境污染的持续挑战导致皮革行业偏离了其最初的可持续发展和环境友好的目标，专注于“废物到价值”的原则。随着聚氨酯（PU）取代聚氯乙烯（PVC）成为合成革表层的主要材料，水性聚氨酯（WPU）和无溶剂聚氨酯（SFPU）成为合成革生产的主要环保原料。自由体积（FV）理论解释了聚合物膜中的传质与聚合物涂层中FV的增加之间的关系，强调了其对水蒸气渗透性（WVP）的好处。合成革的WVP主要受聚合物涂层的亲水性和多孔结构的影响，这是由基础织物和高分子涂层原料决定的。本文综述了制备多孔结构以提高聚合物薄膜或涂层WVP的各种方法：化学吹塑、热膨胀微球、激光打孔、空心微球、表面活性剂稳定泡沫模板和皮克林水泡沫模板。它还提供了目前的问题和前景的简要概述，以提高从这些方法衍生的合成革的透气性。图形抽象

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引用次数: 0

Effects of anionic surfactants SDS and SDBS on the conformation and activity of bacterial collagenase 阴离子表面活性剂SDS和SDBS对细菌胶原酶构象和活性的影响

Journal of Leather Science and Engineering

Pub Date : 2025-11-03 DOI: 10.1186/s42825-025-00222-9

Ke Xu, Xuewei Zhou, Haiming Cheng

Anionic surfactants are essential additives for leather-making, routinely employed on beamhouse processes in combination with industrial enzyme preparations. However, few studies have elaborated the effects of surfactants on bacterial collagenase—a harmful component in industrial enzyme preparations that degrade collagen and impair leather quality. Here, we investigated the effects of two anionic surfactants, sodium dodecyl sulfate (SDS) and sodium dodecyl benzene sulfonate (SDBS), on the activity of collagenase G (ColG), a representative bacterial collagenase. The results showed that both anionic surfactants could significantly inhibit the hydrolytic activity of ColG. In comparison with SDS, SDBS exhibited a stronger inhibitory effect on ColG at lower concentrations. Spectroscopy, molecular docking, and molecular dynamics simulation were employed to investigate the surfactant-bacterial collagenase interactions. The results indicated that both SDS and SDBS inhibited ColG primarily by occupying the active site of ColG and inducing conformational changes in the catalytic region. Compared with SDS, SDBS exhibited significantly higher binding affinity toward ColG and induced more pronounced conformational alterations of collagenase, resulting from π-conjugation effects and steric hindrance of its benzenesulfonate moiety. These findings not only facilitate optimized coordination between surfactants and industrial enzymes in leather-making processes but also provide theoretical support for developing bacterial collagenase inhibitors.

Graphical Abstract

阴离子表面活性剂是制革过程中必不可少的添加剂，通常与工业酶制剂一起用于制革过程。然而，很少有研究详细阐述了表面活性剂对细菌胶原酶的影响——一种工业酶制剂中的有害成分，可降解胶原蛋白并损害皮革质量。本文研究了两种阴离子表面活性剂十二烷基硫酸钠（SDS）和十二烷基苯磺酸钠（SDBS）对细菌胶原酶代表胶原酶G （ColG）活性的影响。结果表明，两种阴离子表面活性剂均能显著抑制ColG的水解活性。与SDS相比，低浓度的SDBS对ColG的抑制作用更强。采用光谱学、分子对接和分子动力学模拟等方法研究表面活性剂与细菌胶原酶的相互作用。结果表明，SDS和SDBS对ColG的抑制作用主要是通过占据ColG的活性位点和诱导催化区构象变化来实现的。与SDS相比，SDBS对ColG具有更高的结合亲和力，且由于其苯磺酸部分的π偶联作用和位阻作用，导致胶原酶的构象改变更为明显。这些发现不仅有助于优化皮革生产过程中表面活性剂和工业酶的协同作用，而且为开发细菌胶原酶抑制剂提供了理论支持。图形抽象

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引用次数: 0

Hydrophobic high-bio-based content waterborne polyurethane prepared by diols and high-molecular weight internal emulsifier 由二醇和高分子量内乳化剂制备的疏水性高生物基含量水性聚氨酯

Journal of Leather Science and Engineering

Pub Date : 2025-10-16 DOI: 10.1186/s42825-025-00214-9

Li Wang, Jun Xiang, Haojun Fan, Zhe Sun

Vegetable oil-based waterborne polyurethanes (WPU) have gained significant attention in the leather industry as sustainable coatings, yet inherently suffer from limited bio-based content, hydrophobicity, and low-temperature resistance due to their reliance on low-molecular weight (Mw) hydrophilic chain extenders and highly functionalized bio-based polyols. To overcome these challenges, we developed a long fatty chain-based design strategy by synthesizing a high-Mw castor oil emulsifier (COE) and two bio-based diols, successfully preparing a novel series of WPU emulsions. When the COE content reached 30%, the emulsions demonstrated good stability while achieving a high-bio-based content of 70.94%. The incorporated long fatty chains endowed the WPU films with good hydrophobicity (water contact angle > 90°), exceptional water resistance (water absorption < 2%), chemical resistance, and self-cleaning properties. Moreover, these high-bio-based content films exhibited tunable thermomechanical performance, including enhanced low-temperature resistance (T_g = 2.8 °C) and improved elongation with increasing Mw, while maintaining excellent thermal stability (T_d5% > 200 °C). This work provides an effective approach for developing sustainable WPU for leather applications with balanced performance properties through strategic molecular design of long fatty chain structures.

Graphical Abstract

植物油基水性聚氨酯（WPU）作为可持续涂料在皮革工业中受到了极大的关注，但由于其依赖于低分子量（Mw）亲水链扩展剂和高度功能化的生物基多元醇，其固有的生物基含量、疏水性和耐低温性有限。为了克服这些挑战，我们开发了一种基于长脂肪链的设计策略，通过合成高mw蓖麻油乳化剂（COE）和两种生物基二醇，成功制备了一系列新的WPU乳剂。当COE含量达到30%时，乳液稳定性良好，生物基含量达到70.94%。加入的长脂肪链赋予WPU膜良好的疏水性（水接触角>； 90°），优异的耐水性（吸水率<； 2%），耐化学性和自清洁性能。此外，这些高生物基含量薄膜表现出可调节的热机械性能，包括增强的耐低温性（Tg = 2.8°C）和随着Mw的增加而提高的伸长率，同时保持优异的热稳定性（Td5% > 200°C）。本研究通过长脂肪链结构的战略性分子设计，为开发具有平衡性能的可持续皮革用WPU提供了有效途径。图形抽象

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引用次数: 0

From leather to the next-generation skin-friendly e-skin 从皮革到下一代亲肤电子皮肤

Journal of Leather Science and Engineering

Pub Date : 2025-10-15 DOI: 10.1186/s42825-025-00220-x

Wan Zheng, Baicun Hao, Xin Huang, Bi Shi

Harnessing the collagenous structural hierarchy of leather is an intriguing strategy for developing the next-generation skin-friendly e-skins with integrated powerful multifunctional sensory capabilities. The current development of e-skins is significantly hindered by the limited breathability for the long-term wearability and the complexity of integrating multimodal sensors within confined device dimensions. The proteinous composition of leather is capable of providing e-skins with exceptional skin affinity, biocompatibility and water vapor permeability, thus guaranteeing the long-term wearing comfortability. The inherent hierarchical fibrous structure of leather combined with the unique reversible cross-scale deformation behaviors enables the in situ construction of highly sensitive microstructured sensors for realizing the miniaturization and integration of multimodal sensors within the constrained space of leather. As a consequence, the development of leather-based e-skins paves a new way for advancing leather industry from traditional manufacture to cutting-edge innovation.

Graphical Abstract

利用真皮的胶原结构层次是开发下一代皮肤友好型电子皮肤的一个有趣的策略，集成了强大的多功能感官能力。目前电子皮肤的发展受到长期可穿戴性的有限透气性和在有限设备尺寸内集成多模态传感器的复杂性的严重阻碍。皮革的蛋白质成分能够为电子皮肤提供优异的皮肤亲和力、生物相容性和透气性，从而保证长期穿着的舒适性。皮革固有的层次化纤维结构和独特的可逆跨尺度变形特性，使得高灵敏度微结构传感器的原位构建成为可能，从而在皮革有限的空间内实现多模态传感器的小型化和集成化。因此，皮革基电子皮革的开发为皮革工业从传统制造走向前沿创新铺平了新的道路。图形抽象

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引用次数: 0

Regulatory mechanism of ι-carrageenan oligosaccharides in coordination with calcium ions on the thermal gelation of sea cucumber collagen α -卡拉胶寡糖与钙离子配合对海参胶原热凝胶化的调控机制

Journal of Leather Science and Engineering

Pub Date : 2025-10-01 DOI: 10.1186/s42825-025-00216-7

Yonghao Liu, Fei Pan, Jiaqi Yu, Zifei Wang, Wenjun Peng, Wenli Tian, Xun Sun, Changhu Xue

Sea cucumbers suffer from non-enzymatic deterioration during heat processing and storage, which significantly devaluates the product. In the present investigation, it was found that ι-carrageenan oligosaccharide (ι-CO) synergized with Ca²⁺ is able to protect sea cucumbers from deterioration. The textural strength and water-holding capacity of the sea cucumber body wall were improved after treatment with ι-CO and Ca²⁺, and the collagen structure was more resistant to destructive experiments. In addition, pepsin-solubilized sea cucumber collagen (SCC) was extracted and demonstrated that the positive effect was due to co-gelation between ι-CO and collagen supported by rheological and thermal property studies. Furthermore, molecular dynamics simulations confirmed that ι-CO spontaneously binds to SCC, while Ca²⁺ promotes the crosslinking strength of the ι-CO-SCC mixed gel and enhances its water-holding capacity and mechanical strength. Therefore, the ι-CO/Ca²⁺ can permeate and stabilize collagen hydrogel, which provides valuable information for the development of new food additives to improve the texture of collagen-based foods.

Graphical Abstract

海参在热处理和储存过程中会发生非酶促变质，从而使产品显著贬值。本研究发现，与Ca2+协同作用的ι-卡拉胶寡糖（ι-CO）具有防止海参变质的作用。经ι-CO和Ca2+处理后，海参体壁的结构强度和持水能力均有所提高，胶原结构更能抵抗破坏性实验。此外，提取了胃蛋白酶溶解的海参胶原（SCC），并通过流变学和热性能研究证明了其积极作用是由于ι-CO与胶原之间的共凝胶作用。此外，分子动力学模拟证实，ι-CO与SCC自发结合，而Ca2+提高了ι-CO-SCC混合凝胶的交联强度，增强了其持水能力和机械强度。因此，ι-CO/Ca2+能够渗透和稳定胶原蛋白水凝胶，为开发新型食品添加剂改善胶原蛋白基食品的质地提供了有价值的信息。图形抽象

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引用次数: 0

Preparation and characterization of acellular membrane from yellowfin tuna (Thunnus albacares) skin for skin regeneration 黄鳍金枪鱼皮肤脱细胞再生膜的制备及性能研究

Journal of Leather Science and Engineering

Pub Date : 2025-09-17 DOI: 10.1186/s42825-025-00218-5

Khoi Minh Le, My-An Tran Le, Vo Minh Quan, Thong Lam Vu, Tin Anh Tran, Phu Phong Vo, An Huyen Lieu, Han Thi Ngoc To, Thi-Hiep Nguyen, Hoan Ngoc Doan

Full-thickness skin wounds pose a considerable clinical challenge because of the limited capacity for self-regeneration. Acellular materials derived from animals offer a promising solution to this issue. In the present investigation, an acellular scaffold is prepared from yellowfin tuna skin (Thunnus albacares) for skin regeneration application by comparing the efficacy of three chemical decellularization agents: sodium hydroxide (NaOH), Triton X-100 (TT), and sodium dodecyl sulfate (SDS). The impact of these agents on the resulting acellular dermal matrices was evaluated by assessing collagen preservation, DNA removal, residual fat and ash content, and structural integrity using hydroxyproline assay and chemical composition analysis. Mechanical properties, swelling behavior, degradation rate, water vapor transmission rate, moisture loss, and biocompatibility of the acellular membrane were also characterized. Furthermore, the regenerative potential of these samples was assessed in a porcine full-thickness skin defect model. The results demonstrated that all three decellularization methods effectively removed cellular components, with varying degrees of collagen preservation and ECM structural alteration. TT treatment yielded the highest collagen retention and a relatively intact fibrous structure, while NaOH caused significant structural damage. Mechanical testing revealed that hydration significantly improved the elasticity of TT- and SDS-treated samples. In vitro biocompatibility assays showed no significant cytotoxicity or hemolysis. These findings suggest that the acellular membrane holds promise as a biomaterial for skin regeneration applications due to its effective decellularization, preserved collagen structure, and favorable biocompatibility.

Graphical Abstract

全层皮肤创面由于自我再生能力有限，给临床带来了相当大的挑战。来源于动物的无细胞材料为这个问题提供了一个有希望的解决方案。本研究通过比较氢氧化钠（NaOH）、Triton X-100 （TT）和十二烷基硫酸钠（SDS）三种化学脱细胞剂的效果，以黄鳍金枪鱼皮肤（Thunnus albacares）为材料制备脱细胞支架用于皮肤再生。这些试剂对脱细胞真皮基质的影响通过评估胶原保存、DNA去除、残余脂肪和灰分含量以及使用羟基脯氨酸测定和化学成分分析的结构完整性来评估。表征了脱细胞膜的力学性能、膨胀行为、降解速率、水蒸气透过率、失湿率和生物相容性。此外，在猪全层皮肤缺损模型中评估了这些样品的再生潜力。结果表明，这三种脱细胞方法都能有效地去除细胞成分，并有不同程度的胶原保存和ECM结构改变。TT处理获得了最高的胶原保留率和相对完整的纤维结构，而NaOH则造成了明显的结构损伤。力学试验表明，水化作用显著提高了TT和sds处理样品的弹性。体外生物相容性试验显示无明显的细胞毒性或溶血作用。这些发现表明，脱细胞膜由于其有效的脱细胞、保存的胶原结构和良好的生物相容性，有望作为皮肤再生应用的生物材料。图形抽象

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引用次数: 0

Multifunctional hydrogel–acellular dermal matrix composite patch: an anticalcification barrier with antibacterial and anti-inflammatory properties for abdominal wall repair 多功能水凝胶-脱细胞真皮基质复合贴片：具有抗菌和抗炎特性的抗钙化屏障，用于腹壁修复

Journal of Leather Science and Engineering

Pub Date : 2025-09-08 DOI: 10.1186/s42825-025-00211-y

Xin Zheng, Ying Zhang, Nianhua Dan, Yining Chen, Zhengjun Li, Yunbing Wang

Calcification, infection, and inflammation are common complications associated with the in vivo application of biological patches. Porcine acellular dermal matrix (pADM), composed mainly of collagen with excellent bioactivity, is widely utilized as a substrate for such patches. However, integrating multiple therapeutic functions into pADM remains a significant challenge. To overcome this limitation, a hydrogel-encapsulated pADM patch (H-Cur-pADM) was developed, aiming to provide barrier protection and multifunctional enhancement. This design involves the in situ formation of a curcumin-loaded hydrogel (GelMA-DTT-Cur) on the surface of pADM via a thiol–ene click reaction. The resulting hybrid not only reinforces the anticalcification capacity of the patch but also imparts anti-infective and anti-inflammatory properties. By combining the mechanical support of pADM with the functional versatility of the hydrogel, this innovative approach enhances the overall performance of the biological patch. The GelMA-DTT-Cur hydrogel layer demonstrated robust structural integrity, interconnected porosity, and sustained release of curcumin micelles following a Fickian diffusion mechanism. In vitro, the hydrogel-encapsulated pADM displayed significant antibacterial activity against Escherichia coli and Staphylococcus aureus, good cytocompatibility, and pronounced anticalcification properties. In vivo studies showed that calcium deposition in the H-Cur-pADM group was only 5.2% of that observed in glutaraldehyde-cross-linked pADM after 21 days of implantation. The H-Cur-pADM patch also displayed strong anti-inflammatory effects and effectively promoted healing in an abdominal wall defect model. This work presents a novel strategy for improving the therapeutic performance of biological patches by integrating drug-loaded hydrogel encapsulation with pADM, offering promising potential for clinical applications in abdominal wall repair.

Graphical Abstract

钙化、感染和炎症是与生物贴片在体内应用相关的常见并发症。猪脱细胞真皮基质（pADM）主要由胶原蛋白组成，具有良好的生物活性，被广泛用作这种贴片的底物。然而，将多种治疗功能整合到pADM中仍然是一个重大挑战。为了克服这一限制，开发了一种水凝胶封装的pADM贴片（H-Cur-pADM），旨在提供屏障保护和多功能增强。该设计涉及通过巯基点击反应在pADM表面原位形成装载姜黄素的水凝胶（GelMA-DTT-Cur）。由此产生的混合物不仅加强了贴片的抗钙化能力，而且还赋予抗感染和抗炎特性。通过将pADM的机械支持与水凝胶的功能通用性相结合，这种创新的方法增强了生物贴片的整体性能。GelMA-DTT-Cur水凝胶层表现出坚固的结构完整性，相互连接的孔隙，以及在菲克扩散机制下姜黄素胶束的持续释放。在体外，水凝胶包封的pADM对大肠杆菌和金黄色葡萄球菌具有明显的抗菌活性，具有良好的细胞相容性和明显的抗钙化性能。体内研究表明，植入21天后，h - cu -pADM组的钙沉积仅为戊二醛交联pADM组的5.2%。h - cu - padm贴片也显示出很强的抗炎作用，并有效促进腹壁缺损模型的愈合。本研究提出了一种通过将载药水凝胶包封与pADM结合来提高生物贴片治疗性能的新策略，为腹壁修复的临床应用提供了广阔的前景。图形抽象

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引用次数: 0

Discovering potential anti-skin-aging peptides in collagen: computer-assisted rapid screening and structure–activity relationships 发现胶原蛋白中潜在的抗皮肤衰老肽：计算机辅助快速筛选和构效关系

Journal of Leather Science and Engineering

Pub Date : 2025-09-01 DOI: 10.1186/s42825-025-00215-8

Ruihao Zhang, Yang Li, Yonghui Li, Hui Zhang

The application of peptides as inhibitors of skin aging is a promising area of research. Previous researches have predominantly focused on extracting anti-aging peptides from the collagen of specific animals, while large-scale rapid screening and analysis of the structure–activity relationships of these peptides have been scarcely reported. In the present investigation, we developed a machine learning model for screening potential anti-skin-aging peptides (PASAPs), achieving a Matthews correlation coefficient (MCC) of 0.927 ± 0.044 and balanced accuracy (BACC) of 0.963 ± 0.022. These metrics surpassed those of the existing PeptideRanker model, which is widely used in bioactive peptide studies. Based on in silico screening, we identified and synthesized six novel PASAPs derived from tilapia collagen: KKHVWFGE, NGTPGAMGPR, PGAAGLKGDR, DGAPGPKGDR, TGPVGMPGAR, and GAPGGAGGVGEPGR. In vitro assays revealed that all six peptides exhibited significant inhibitory activity against aging-related enzymes, with the most pronounced effects on elastase and collagenase. A comprehensive analysis of the C-terminal amino acid residues indicated that the presence of arginine (R) at the C-terminus notably enhanced peptide binding to aging-related enzymes. This enhancement was attributed to an increased number of hydrogen bonds and stronger chemical interactions, which augmented the aging-related enzyme inhibitory activity of the peptides. In summary, this study proposed an effective strategy for discovering PASAPs from collagen and validated the machine learning model through experimental evidence. Structure–activity relationship insights can guide the synthesis of bioactive peptides and the selection of proteases for bioactive peptide production.

Graphical Abstract

多肽作为皮肤衰老抑制剂的应用是一个很有前途的研究领域。以往的研究主要集中在从特定动物的胶原蛋白中提取抗衰老肽，而大规模快速筛选和分析这些肽的构效关系的报道很少。在本研究中，我们建立了一个筛选潜在抗皮肤衰老肽（PASAPs）的机器学习模型，其马修斯相关系数（MCC）为0.927±0.044，平衡精度（BACC）为0.963±0.022。这些指标超过了现有的PeptideRanker模型，该模型广泛用于生物活性肽的研究。在硅基筛选的基础上，我们从罗非鱼胶原蛋白中鉴定并合成了6种新的PASAPs: KKHVWFGE、NGTPGAMGPR、PGAAGLKGDR、DGAPGPKGDR、TGPVGMPGAR和GAPGGAGGVGEPGR。体外实验表明，这六种多肽对衰老相关酶均表现出显著的抑制活性，其中对弹性酶和胶原酶的抑制作用最为明显。c端氨基酸残基的综合分析表明，c端精氨酸(R)的存在显著增强了肽与衰老相关酶的结合。这种增强归因于氢键数量的增加和更强的化学相互作用，这增强了肽的衰老相关酶抑制活性。综上所述，本研究提出了从胶原蛋白中发现PASAPs的有效策略，并通过实验证据验证了机器学习模型。结构-活性关系的认识可以指导生物活性肽的合成和选择用于生物活性肽生产的蛋白酶。图形抽象

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引用次数: 0

Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy 仿生天然纤维衍生的电子皮肤，配备智能药物释放系统，用于先进的强大集成黑色素瘤治疗

Journal of Leather Science and Engineering

Pub Date : 2025-08-15 DOI: 10.1186/s42825-025-00210-z

Xinhua Liu, Yifan Fei, Boqiang Cui, Xing Chen, Jiamin Zhang, Ouyang Yue, Zhongxue Bai, Ling Wen, Huie Jiang

Malignant melanoma, a highly aggressive malignancy, necessitates innovative therapeutic strategies integrating biomaterial innovation with multimodal treatment modalities. Herein, we report the development of a collagen-derived bioelectronic skin (c-ADM) nanoengineered via interfacial assembly of porcine acellular dermal matrix (ADM)—a natural collagen-rich scaffold—with conductive poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and copper sulfide nanoparticles (CuS-NPs). This hybrid system synergizes photothermal ablation, stimuli-responsive drug delivery, and electrostimulation (ES) for comprehensive postoperative melanoma management and tissue regeneration. The c-ADM platform exhibits superior mechanical robustness, enzymatic resistance, and biocompatibility, enabling real-time motion monitoring while maintaining structural integrity in dynamic physiological environments. Leveraging the photothermal efficiency of CuS-NPs, localized hyperthermia (ΔT > 40 °C) under near-infrared (NIR) irradiation induces irreversible melanoma cell apoptosis. Concurrently, laser-triggered temperature-responsive drug release enables synchronized photothermal-chemotherapy, with sustained doxorubicin release profiles at tumor sites. Notably, pH-responsive Cu²⁺ liberation from CuS-NPs facilitates intelligent functional switching: bactericidal activity at tumor microenvironment pH (5.0–6.0) and pro-regenerative effects under physiological pH (7.4) for wound healing. In vitro/in vivo assessments confirm c-ADM’s dual therapeutic efficacy including ES-enhanced cancer cell death via mitochondrial dysfunction and accelerated full-thickness skin regeneration through collagen remodeling and angiogenesis modulation. This work establishes a collagen-based bioelectronic scaffold for personalized oncological care, integrating intraoperative tumor eradication, postoperative surveillance, and adaptive tissue reconstruction.

Graphic Abstract

恶性黑色素瘤是一种高度侵袭性的恶性肿瘤，需要创新的治疗策略，将生物材料创新与多模式治疗模式结合起来。在此，我们报道了一种胶原源性生物电子皮肤（c-ADM）纳米工程的发展，该工程通过猪脱细胞真皮基质(ADM) -一种天然富含胶原的支架-具有导电聚（3,4-乙烯二氧噻吩）、聚（苯乙烯磺酸盐）（PEDOT:PSS）和硫化铜纳米颗粒（cu - nps）的界面组装而成。这种混合系统将光热消融、刺激反应性药物输送和电刺激（ES）协同作用，用于全面的黑色素瘤术后管理和组织再生。c-ADM平台具有优异的机械稳健性、抗酶性和生物相容性，能够在动态生理环境中实现实时运动监测，同时保持结构完整性。利用cu - nps的光热效率，近红外（NIR）照射下的局部热疗（ΔT > 40°C）可诱导不可逆的黑色素瘤细胞凋亡。同时，激光触发的温度响应药物释放可以实现同步光热化疗，在肿瘤部位持续释放阿霉素。值得注意的是，pH响应Cu2 +从cu - nps中释放，促进了智能功能切换：肿瘤微环境pH值（5.0-6.0）下的杀菌活性和生理pH值（7.4）下的促再生作用，有助于伤口愈合。体外/体内评估证实了c-ADM的双重治疗功效，包括通过线粒体功能障碍增强es癌细胞死亡，通过胶原重塑和血管生成调节加速全层皮肤再生。本研究建立了一种基于胶原蛋白的生物电子支架，用于个性化肿瘤护理，集术中肿瘤根除、术后监测和适应性组织重建于一体。图形抽象

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引用次数: 0

Collagen-based biomaterials in neural injury repair: current advances and future perspectives 胶原基生物材料在神经损伤修复中的应用：目前进展和未来展望

Journal of Leather Science and Engineering

Pub Date : 2025-08-10 DOI: 10.1186/s42825-025-00209-6

Fei Fang, Xiaoli Wang, Yijun Tao, Yujie Su, Weihua Dan, Zhanhong Du, Xiaoheng Liu, Yang Shen

Neural injuries, such as traumatic brain injury, spinal cord injury, and peripheral nerve injury, result in substantial physical and functional impairments, significantly reducing quality of life. Current treatments, including drug therapy and surgical interventions, have limited efficacy in promoting neural regeneration and facilitating functional recovery. To overcome these limitations, collagen-based biomaterials have emerged as a promising alternative, owing to their biocompatibility, biodegradability, low immunogenicity, and ability to mimic the natural extracellular matrix. This review highlights recent applications of collagen-based materials in neural injury repair, including cell therapies, neurotrophin delivery, and extracellular vesicle carriers. These materials have shown potential in promoting cell survival, axonal regeneration, and reducing inflammation across various neural injury models. Despite challenges in optimizing scaffold design, controlling drug release, and ensuring biocompatibility, promising preclinical results suggest a bright future for collagen-based biomaterials in treating neural injuries.

Graphical Abstract

神经损伤，如创伤性脑损伤、脊髓损伤和周围神经损伤，会导致严重的身体和功能损伤，显著降低生活质量。目前的治疗方法，包括药物治疗和手术干预，在促进神经再生和促进功能恢复方面的效果有限。为了克服这些限制，基于胶原蛋白的生物材料由于其生物相容性、生物可降解性、低免疫原性和模仿天然细胞外基质的能力而成为一种有希望的替代品。本文综述了近年来胶原基材料在神经损伤修复中的应用，包括细胞治疗、神经营养蛋白递送和细胞外囊泡载体。这些材料在促进细胞存活、轴突再生和减少各种神经损伤模型的炎症方面显示出潜力。尽管在优化支架设计、控制药物释放和确保生物相容性方面存在挑战，但临床前研究结果表明，胶原基生物材料在治疗神经损伤方面具有光明的前景。图形抽象

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