Pub Date : 2025-06-01DOI: 10.1186/s42825-025-00197-7
Qinghe Zhang, Minghuan Dou, Xinyi Su, Zelong Yu, Benmei Wei, Lian Zhu, Juntao Zhang, Haibo Wang
Cell migration is a fundamental biological process that plays a crucial role in both physiological and pathological conditions, and is largely influenced by the complex microenvironment, particularly the extracellular matrix (ECM), a macromolecular network that governs various cellular interactions. Extensive research has established that ECM-cell interactions are critical in multiple biological processes, with some directly regulating cell migration. Among ECM components, collagens stand out as key regulators of cell movement. However, existing reviews have provided only limited perspectives on the role of collagen-based biomaterials in directing migration across different cell populations. This gap in knowledge hinders a comprehensive understanding of collagen’s full potential. Drawing from systematic literature and our ongoing research, this review aims to summarize advancements over the past five years in the application of collagen-based biomaterials for modulating cell migration. The discussion primarily focuses on three pivotal cell types: stem cells, immune cells, and cancer cells. By shedding light on the functions, mechanisms, and therapeutic potential of collagen in cell migration, this review will contribute to the development of innovative collagen-based biomaterials with applications in wound healing and tissue regeneration.
{"title":"Collagen-based biomaterials: recent advances on regulating cell migration and correlated biomedical applications","authors":"Qinghe Zhang, Minghuan Dou, Xinyi Su, Zelong Yu, Benmei Wei, Lian Zhu, Juntao Zhang, Haibo Wang","doi":"10.1186/s42825-025-00197-7","DOIUrl":"10.1186/s42825-025-00197-7","url":null,"abstract":"<div><p>Cell migration is a fundamental biological process that plays a crucial role in both physiological and pathological conditions, and is largely influenced by the complex microenvironment, particularly the extracellular matrix (ECM), a macromolecular network that governs various cellular interactions. Extensive research has established that ECM-cell interactions are critical in multiple biological processes, with some directly regulating cell migration. Among ECM components, collagens stand out as key regulators of cell movement. However, existing reviews have provided only limited perspectives on the role of collagen-based biomaterials in directing migration across different cell populations. This gap in knowledge hinders a comprehensive understanding of collagen’s full potential. Drawing from systematic literature and our ongoing research, this review aims to summarize advancements over the past five years in the application of collagen-based biomaterials for modulating cell migration. The discussion primarily focuses on three pivotal cell types: stem cells, immune cells, and cancer cells. By shedding light on the functions, mechanisms, and therapeutic potential of collagen in cell migration, this review will contribute to the development of innovative collagen-based biomaterials with applications in wound healing and tissue regeneration.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00197-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Developing chrome-free tanning agents to manufacture eco-leather products is the most promising way to address chrome pollution and achieve a sustainable leather industry. Herein, we report on a facile strategy to synthesize a novel biomass-based epoxy tanning agent (BET) based on sucrose and γ-(2,3-epoxypropoxy) propytrimethoxysilane (KH560). FTIR, XPS, 29Si NMR, and GPC analyses confirmed the reaction between sucrose and KH560 via forming Si–O–C bonds, suggesting the successful preparation of BET. The subsequent application experiments showed that the BET-tanned leather demonstrated superior performance with a well-organized collagen fiber network and a shrinkage temperature exceeding 80 °C, outperforming commercial TWS-tanned leather in thermal stability during post-tanning and resistance to yellowing. Moreover, the BET-tanned crust leather exhibited enhanced tensile strength (25.65 vs. 16.18 N/mm2) and tear resistance (84.01 vs. 60.71 N/mm) compared to TWS-tanned crust leather, along with reduced extensibility under a specific load and at break. Compared with the TWS-tanned crust leather, the BET-tanned crust leather also displayed superior smooth grain surface, dyeing uniformity, softness, and fullness. These promising results pave the way for developing alternative chrome-free tanning agents, aiding the sustainable development of the leather industry.
Graphical abstract
开发无铬鞣剂生产生态皮革产品是解决铬污染和实现皮革工业可持续发展的最有希望的途径。本文报道了一种基于蔗糖和γ-（2,3-环氧丙氧基）丙基三甲氧基硅烷（KH560）的新型生物质基环氧鞣剂（BET）的合成方法。FTIR， XPS， 29Si NMR和GPC分析证实了蔗糖与KH560之间通过形成Si-O-C键的反应，表明BET的制备成功。随后的应用实验表明，bet鞣革具有良好的胶原纤维网络，收缩温度超过80℃，鞣革后的热稳定性和抗黄变性能优于tws鞣革。此外，与tws鞣制皮皮相比，bet鞣制皮皮的抗拉强度（25.65 N/mm2 vs. 16.18 N/mm2）和抗撕裂性（84.01 N/mm vs. 60.71 N/mm）有所提高，在特定载荷和断裂下的延伸性也有所降低。与tws鞣皮皮相比，bet鞣皮皮的纹路光滑、染色均匀性、柔软度和丰满度均优于tws鞣皮。这些有希望的结果为开发替代无铬鞣剂铺平了道路，有助于皮革工业的可持续发展。图形抽象
{"title":"Engineering an epoxy tanning agent via facile functionalization of sucrose with silane coupling agent for sustainable leather production","authors":"Wei Ding, Xinyue Wang, Javier Remón, Zhicheng Jiang, Xiaoyan Pang, Zhiwen Ding, Yibo Wu","doi":"10.1186/s42825-025-00200-1","DOIUrl":"10.1186/s42825-025-00200-1","url":null,"abstract":"<div><p>Developing chrome-free tanning agents to manufacture eco-leather products is the most promising way to address chrome pollution and achieve a sustainable leather industry. Herein, we report on a facile strategy to synthesize a novel biomass-based epoxy tanning agent (BET) based on sucrose and γ-(2,3-epoxypropoxy) propytrimethoxysilane (KH560). FTIR, XPS, <sup>29</sup>Si NMR, and GPC analyses confirmed the reaction between sucrose and KH560 via forming Si–O–C bonds, suggesting the successful preparation of BET. The subsequent application experiments showed that the BET-tanned leather demonstrated superior performance with a well-organized collagen fiber network and a shrinkage temperature exceeding 80 °C, outperforming commercial TWS-tanned leather in thermal stability during post-tanning and resistance to yellowing. Moreover, the BET-tanned crust leather exhibited enhanced tensile strength (25.65 vs<i>.</i> 16.18 N/mm<sup>2</sup>) and tear resistance (84.01 vs<i>.</i> 60.71 N/mm) compared to TWS-tanned crust leather, along with reduced extensibility under a specific load and at break. Compared with the TWS-tanned crust leather, the BET-tanned crust leather also displayed superior smooth grain surface, dyeing uniformity, softness, and fullness. These promising results pave the way for developing alternative chrome-free tanning agents, aiding the sustainable development of the leather industry.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00200-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145170525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Collagen, an abundant extracellular matrix protein in food-producing animals, is widely integrated into food systems for its unique physicochemical properties. Oral collagen-based supplements have received increasing attention for their potential to enhance overall well-being. This review aims to provide valuable insights into the application of oral collagen supplements in food systems, promoting their broader use in food processing, preservation, and the development of functional foods. Specifically, the applications of oral collagen-based supplements in functional foods, focusing on their biological activities, health benefits, and functional properties are summarized. Importantly, their molecular mechanisms of biological activities are critically discussed, including antioxidant, angiotensin-converting enzyme inhibitory, and dipeptidyl peptidase IV inhibitory activities. The health benefits of oral collagen-based supplements, particularly in improving skin, immune, and gastrointestinal health are also explored. Additionally, various functional properties of collagen-based supplements are evaluated, including their stability, bioavailability, taste masking, and sensory attributes.
{"title":"Oral collagen-based supplement as a bioactive component in functional foods","authors":"Yue Wu, Siqi Deng, Wenqi Wei, Yuanmeng He, Yunxiang He, Gonghua Hong, Yanbin Zheng, Linli Han, Yifei Li, Yimin Hua, Junling Guo","doi":"10.1186/s42825-025-00198-6","DOIUrl":"10.1186/s42825-025-00198-6","url":null,"abstract":"<div><p>Collagen, an abundant extracellular matrix protein in food-producing animals, is widely integrated into food systems for its unique physicochemical properties. Oral collagen-based supplements have received increasing attention for their potential to enhance overall well-being. This review aims to provide valuable insights into the application of oral collagen supplements in food systems, promoting their broader use in food processing, preservation, and the development of functional foods. Specifically, the applications of oral collagen-based supplements in functional foods, focusing on their biological activities, health benefits, and functional properties are summarized. Importantly, their molecular mechanisms of biological activities are critically discussed, including antioxidant, angiotensin-converting enzyme inhibitory, and dipeptidyl peptidase IV inhibitory activities. The health benefits of oral collagen-based supplements, particularly in improving skin, immune, and gastrointestinal health are also explored. Additionally, various functional properties of collagen-based supplements are evaluated, including their stability, bioavailability, taste masking, and sensory attributes.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00198-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-08DOI: 10.1186/s42825-025-00195-9
Zhenpeng Cai, Yujia Xiang, Boyi Cong, Yang Liu, Shuai Yang, Ningruo Wang, Heng Zhang, Yuzhong Wang, Bo Lai
Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) is commonly used as a preservative and fungicide in leather production that leads to its presence in tannery wastewater. As a typical organic phosphorus pollutant, THPS poses potential threats to both the ecological environment and human health. Herein, this investigation used the microscale zero-valent iron (mZVI)/O3 process to eliminate THPS from aquatic environments. The mZVI/O3 system demonstrated superior removal performance, achieving high removal efficiencies of total phosphorus (TP), organic phosphorus (OP), and chemical oxygen demand (COD) compared to traditional systems (i.e., mZVI alone, O3 alone, Fe2+/O3, and Fe3+/O3). Moreover, batch experiments were conducted to optimize the key operational parameters (such as initial pH, mZVI dosage, O3 concentration, and stirring rate). The TP, OP, and COD removal efficiencies in the mZVI/O3 system reached 97.10%, 97.31%, and 81.56% within 20 min, respectively, under optimized conditions. Based on the experimental results and characterization analysis, the THPS degradation mechanism by the mZVI/O3 system was primarily a combination of oxidation (60.37% ± 7.41%) and flocculation (39.63% ± 7.41%). Furthermore, the mZVI/O3 system demonstrated unprecedented removal performance in various actual wastewater samples. The system eliminated organic pollutants and improved biodegradability of actual wastewater. This study not only establishes the mZVI/O3 process as a robust, cost-effective, and environmentally sound approach for OP degradation but also offers substantial promise for practical wastewater treatment applications.
{"title":"Organophosphorus pollutant degradation in wastewater using the microscale zero-valent iron/O3 process: optimization, performance, and mechanism","authors":"Zhenpeng Cai, Yujia Xiang, Boyi Cong, Yang Liu, Shuai Yang, Ningruo Wang, Heng Zhang, Yuzhong Wang, Bo Lai","doi":"10.1186/s42825-025-00195-9","DOIUrl":"10.1186/s42825-025-00195-9","url":null,"abstract":"<div><p>Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) is commonly used as a preservative and fungicide in leather production that leads to its presence in tannery wastewater. As a typical organic phosphorus pollutant, THPS poses potential threats to both the ecological environment and human health. Herein, this investigation used the microscale zero-valent iron (mZVI)/O<sub>3</sub> process to eliminate THPS from aquatic environments. The mZVI/O<sub>3</sub> system demonstrated superior removal performance, achieving high removal efficiencies of total phosphorus (TP), organic phosphorus (OP), and chemical oxygen demand (COD) compared to traditional systems (i.e., mZVI alone, O<sub>3</sub> alone, Fe<sup>2+</sup>/O<sub>3</sub>, and Fe<sup>3+</sup>/O<sub>3</sub>). Moreover, batch experiments were conducted to optimize the key operational parameters (such as initial pH, mZVI dosage, O<sub>3</sub> concentration, and stirring rate). The TP, OP, and COD removal efficiencies in the mZVI/O<sub>3</sub> system reached 97.10%, 97.31%, and 81.56% within 20 min, respectively, under optimized conditions. Based on the experimental results and characterization analysis, the THPS degradation mechanism by the mZVI/O<sub>3</sub> system was primarily a combination of oxidation (60.37% ± 7.41%) and flocculation (39.63% ± 7.41%). Furthermore, the mZVI/O<sub>3</sub> system demonstrated unprecedented removal performance in various actual wastewater samples. The system eliminated organic pollutants and improved biodegradability of actual wastewater. This study not only establishes the mZVI/O<sub>3</sub> process as a robust, cost-effective, and environmentally sound approach for OP degradation but also offers substantial promise for practical wastewater treatment applications.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00195-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To enhance the utilization of pesticides and reduce environmental risks, we constructed the magnetic recyclable and dual stimulus-responsive microspheres to achieve on-demand pesticide release. Magnetic multi-shell hollow mesoporous organosilicon nanoparticles (mMSN) were prepared by one-step hydrothermal method and loaded with pesticide avermectin (A@mMSN), afterward A@mMSN was coated with gelatin through emulsification and chemical cross-linking to prepare A@mMSN@G microspheres (21.5 ± 9.7 μm). After being absorbed by the pests, the gelatin layer was hydrolyzed with the neutral protease, and the disulfide bonds within mMSN framework were decomposed by glutathione (GSH), endowing A@mMSN@G microspheres with enzyme and GSH responsiveness to achieve sustained avermectin release till 7 days (about 3.5 times that of the commercial avermectin emulsion). Importantly, the A@mMSN@G microspheres containing Fe3O4 nanoparticles could be easily magnetically collected from soil with a recovery ratio of 63.7%, to reduce the environmental risks. With excellent biosafety, A@mMSN@G microspheres showed outstanding pest control effects till two weeks and the growth of cabbage was not affected by it. Therefore, based on the recyclability and dual stimulus-responsive controllable release, the fabricated A@mMSN@G microspheres have broad application potential in pesticide delivery.
{"title":"Enzyme–and GSH–responsive gelatin coated magnetic multi-shell hollow mesoporous organosilicon nanoparticles for avermectin controlled release","authors":"Jiazhen Gao, Pengyu Luo, Siqiang Shen, Ying Liu, Xiaoyun Li, Xiaoying Wang","doi":"10.1186/s42825-025-00191-z","DOIUrl":"10.1186/s42825-025-00191-z","url":null,"abstract":"<div><p>To enhance the utilization of pesticides and reduce environmental risks, we constructed the magnetic recyclable and dual stimulus-responsive microspheres to achieve on-demand pesticide release. Magnetic multi-shell hollow mesoporous organosilicon nanoparticles (mMSN) were prepared by one-step hydrothermal method and loaded with pesticide avermectin (A@mMSN), afterward A@mMSN was coated with gelatin through emulsification and chemical cross-linking to prepare A@mMSN@G microspheres (21.5 ± 9.7 μm). After being absorbed by the pests, the gelatin layer was hydrolyzed with the neutral protease, and the disulfide bonds within mMSN framework were decomposed by glutathione (GSH), endowing A@mMSN@G microspheres with enzyme and GSH responsiveness to achieve sustained avermectin release till 7 days (about 3.5 times that of the commercial avermectin emulsion). Importantly, the A@mMSN@G microspheres containing Fe<sub>3</sub>O<sub>4</sub> nanoparticles could be easily magnetically collected from soil with a recovery ratio of 63.7%, to reduce the environmental risks. With excellent biosafety, A@mMSN@G microspheres showed outstanding pest control effects till two weeks and the growth of cabbage was not affected by it. Therefore, based on the recyclability and dual stimulus-responsive controllable release, the fabricated A@mMSN@G microspheres have broad application potential in pesticide delivery.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00191-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1186/s42825-025-00190-0
Pengfei Qiao, Jie Liu, Liqiang Jin, Feifei Zhang, Zhonghe Feng, Yulu Wang
Despite its potential as a metal-free tanning agent capable of eliminating Cr pollution in the leather industry, the conventional preparation of poly(carbamoyl sulfonate) faces challenges, such as the extensive use of low-boiling organic solvents and low blocking ratios of –NCO groups. Herein, a liquid sulfonate chain extender, 2,3-dihydroxypropanesulfonic acid triethylamine salt (DHPSTEA), was initially synthesized. A series of poly(carbamoyl sulfonate) tanning agents (CTAS) were then synthesized using DHPSTEA and various diisocyanates as reaction monomers, with sodium bisulfite serving as the blocking agent and without utilizing organic solvents. CTAS demonstrated a blocking ratio of > 99% and satisfactory stability under acidic conditions at room temperature. Application experiments revealed that CTAS exhibited excellent tanning performance, with the parent diisocyanate monomer markedly influencing their tanning properties. CTAS synthesized with dicyclohexylmethane-4,4′-diisocyanate resulted in optimal product performance, yielding a shrinkage temperature of 83.2 °C at a 6% dosage. CTAS-tanned leather displayed excellent collagen fiber dispersion, yellowing resistance and mechanical properties. Additionally, CTAS is easy to biodegrade (BOD5/COD > 0.45). Thus, this novel metal-free tanning agent holds a great potential as a sustainable alternative to traditional chrome tanning agent.
{"title":"Ecofriendly and sustainable metal-free leather tanning using novel poly(carbamoyl sulfonate) technology","authors":"Pengfei Qiao, Jie Liu, Liqiang Jin, Feifei Zhang, Zhonghe Feng, Yulu Wang","doi":"10.1186/s42825-025-00190-0","DOIUrl":"10.1186/s42825-025-00190-0","url":null,"abstract":"<div><p>Despite its potential as a metal-free tanning agent capable of eliminating Cr pollution in the leather industry, the conventional preparation of poly(carbamoyl sulfonate) faces challenges, such as the extensive use of low-boiling organic solvents and low blocking ratios of –NCO groups. Herein, a liquid sulfonate chain extender, 2,3-dihydroxypropanesulfonic acid triethylamine salt (DHPSTEA), was initially synthesized. A series of poly(carbamoyl sulfonate) tanning agents (CTAS) were then synthesized using DHPSTEA and various diisocyanates as reaction monomers, with sodium bisulfite serving as the blocking agent and without utilizing organic solvents. CTAS demonstrated a blocking ratio of > 99% and satisfactory stability under acidic conditions at room temperature. Application experiments revealed that CTAS exhibited excellent tanning performance, with the parent diisocyanate monomer markedly influencing their tanning properties. CTAS synthesized with dicyclohexylmethane-4,4′-diisocyanate resulted in optimal product performance, yielding a shrinkage temperature of 83.2 °C at a 6% dosage. CTAS-tanned leather displayed excellent collagen fiber dispersion, yellowing resistance and mechanical properties. Additionally, CTAS is easy to biodegrade (BOD<sub>5</sub>/COD > 0.45). Thus, this novel metal-free tanning agent holds a great potential as a sustainable alternative to traditional chrome tanning agent.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00190-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1186/s42825-025-00189-7
Ruibin Li, Chen Yang, Yuanqing Liu, Yue Yu
Fatliquor migration within the leather matrix may lead to the formation of fatty spew, oil patches and fogging, posing challenges to the production of high-quality leather. Currently, it lacks a straightforward and effective method for analyzing fatliquor migration behavior. This investigation introduces a novel approach for analyzing fatliquor migration by measuring its spreading area on collagen fiber membranes. By applying 300 mg of fatliquor onto 0.5 mm square membranes (10 cm × 10 cm), distinct oil spots were observed, enabling analysis of migration behavior. Using stearic acid as a standard reference compound effectively minimized the influence of different leather sections on fatliquor migration. Fatliquors with low molecular weight, low melting point and high aliphatic ester content exhibited obvious migration potential. Organic-tanned leathers and sulfated fatliquors displayed weak interactions, resulting in easy fatliquor migration within the leather. Conversely, metal-tanned leathers and phosphorylated fatliquors demonstrated strong interactions, effectively hindering migration. This research provides valuable practical and theoretical insights for developing effective strategies to prevent and control fatliquor migration in leather production.
Graphical abstract
加脂剂在皮革基体内的迁移可能导致脂肪喷涌、油斑和雾气的形成，对高品质皮革的生产构成挑战。目前，还缺乏一种简单有效的方法来分析加脂剂的迁移行为。本研究介绍了一种通过测量加脂剂在胶原纤维膜上的扩散面积来分析加脂剂迁移的新方法。将300 mg加脂剂涂在0.5 mm平方的膜上（10 cm × 10 cm），观察到明显的油斑，从而分析迁移行为。使用硬脂酸作为标准参考化合物，有效地减少了不同皮革部分对加脂剂迁移的影响。低分子量、低熔点、高脂肪脂含量的脂质具有明显的迁移潜力。有机鞣革和硫酸盐加脂剂表现出弱相互作用，导致加脂剂容易在皮革内迁移。相反，金属鞣制皮革和磷酸化脂质表现出强烈的相互作用，有效地阻碍了迁移。该研究为制定有效的策略来预防和控制皮革生产中的加脂剂迁移提供了有价值的实践和理论见解。图形抽象
{"title":"A novel approach for analyzing the migration behavior of fatliquors within leather","authors":"Ruibin Li, Chen Yang, Yuanqing Liu, Yue Yu","doi":"10.1186/s42825-025-00189-7","DOIUrl":"10.1186/s42825-025-00189-7","url":null,"abstract":"<div><p>Fatliquor migration within the leather matrix may lead to the formation of fatty spew, oil patches and fogging, posing challenges to the production of high-quality leather. Currently, it lacks a straightforward and effective method for analyzing fatliquor migration behavior. This investigation introduces a novel approach for analyzing fatliquor migration by measuring its spreading area on collagen fiber membranes. By applying 300 mg of fatliquor onto 0.5 mm square membranes (10 cm × 10 cm), distinct oil spots were observed, enabling analysis of migration behavior. Using stearic acid as a standard reference compound effectively minimized the influence of different leather sections on fatliquor migration. Fatliquors with low molecular weight, low melting point and high aliphatic ester content exhibited obvious migration potential. Organic-tanned leathers and sulfated fatliquors displayed weak interactions, resulting in easy fatliquor migration within the leather. Conversely, metal-tanned leathers and phosphorylated fatliquors demonstrated strong interactions, effectively hindering migration. This research provides valuable practical and theoretical insights for developing effective strategies to prevent and control fatliquor migration in leather production.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00189-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-24DOI: 10.1186/s42825-025-00192-y
Yan Liu, Can Cheng, Jiaqi Xing, Zhaoxi Deng, Xu Peng
Despite advances in synthetic vascular grafts, replicating the dynamic biological functions of native microvasculature remains a critical challenge in cardiovascular tissue engineering. While polymer-based conduits offer scalability and dimensional versatility, the inherent bioinert nature leads to high failure rates in < 6 mm diameter applications due to thrombotic complications and mechanical mismatch with host tissue. Decellularized matrices (dECM) scaffolds emerge as a biologically strategic alternative, preserving crucial vascular basement membrane components and biomechanical cues through collagen/elastin retention. The present review systematically elaborates the research advancements, critical determinants, and practical challenges in utilizing dECM for tiny-diameter artificial vessels (inner diameter < 3 mm), while proposing three forward-looking solutions to address clinical translation barriers: (1) matrix optimization strategies through diameter-specific compliance matching and elastin reconstitution; (2) sterilization and preservation protocols preserving structural integrity with controlled immunogenicity; (3) immunomodulatory engineering via macrophage polarization regulation. The proposed methodologies establish innovative avenues for the engineering and clinical transplantation of tiny-diameter artificial vessels.
{"title":"Recent advances and practical challenges in the research of decellularized matrices for the fabrication of tiny-diameter artificial arteries","authors":"Yan Liu, Can Cheng, Jiaqi Xing, Zhaoxi Deng, Xu Peng","doi":"10.1186/s42825-025-00192-y","DOIUrl":"10.1186/s42825-025-00192-y","url":null,"abstract":"<div><p>Despite advances in synthetic vascular grafts, replicating the dynamic biological functions of native microvasculature remains a critical challenge in cardiovascular tissue engineering. While polymer-based conduits offer scalability and dimensional versatility, the inherent bioinert nature leads to high failure rates in < 6 mm diameter applications due to thrombotic complications and mechanical mismatch with host tissue. Decellularized matrices (dECM) scaffolds emerge as a biologically strategic alternative, preserving crucial vascular basement membrane components and biomechanical cues through collagen/elastin retention. The present review systematically elaborates the research advancements, critical determinants, and practical challenges in utilizing dECM for tiny-diameter artificial vessels (inner diameter < 3 mm), while proposing three forward-looking solutions to address clinical translation barriers: (1) matrix optimization strategies through diameter-specific compliance matching and elastin reconstitution; (2) sterilization and preservation protocols preserving structural integrity with controlled immunogenicity; (3) immunomodulatory engineering via macrophage polarization regulation. The proposed methodologies establish innovative avenues for the engineering and clinical transplantation of tiny-diameter artificial vessels.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00192-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-20DOI: 10.1186/s42825-025-00193-x
Haofei Xu, Yang Liu, Longxue Qiu, Antonio Lorenzo Masa Mbomio Mangue, Juntao Zhang, Benmei Wei, Lian Zhu, Chengzhi Xu, Evgeny A. Shirshin, Haibo Wang
Traumatic wounds are the prevalent scenarios encountered in battleground and emergency rooms. The rapid and effective hemostasis is imperative for life saving in these scenarios, for which the development of high-efficiency and biocompatible hemostatic materials is essential. Due to its excellent hemostatic property and biocompatibility, collagen has emerged as an ideal component of hemostatic materials. Furthermore, the properties of collagen-based hemostatic materials could be improved by the integration of other biomacromolecules, such as alginate, cellulose derivatives, and chitosan derivatives. Therefore, more and more novel hemostatic materials with exceptional hemostatic properties have been developed. This review aims to overview recent progress of collagen-based hemostatic materials. Firstly, the hemostatic mechanism of collagen was introduced. Secondly, various forms of collagen-based hemostatic materials, such as hydrogels, sponges, and powders, were highlighted. Thirdly, composite hemostatic materials of collagen and other biomacromolecules were overviewed. Finally, the outlook of collagen-based hemostatic materials was discussed.
{"title":"Preparation and application of collagen-based hemostatic materials: a review","authors":"Haofei Xu, Yang Liu, Longxue Qiu, Antonio Lorenzo Masa Mbomio Mangue, Juntao Zhang, Benmei Wei, Lian Zhu, Chengzhi Xu, Evgeny A. Shirshin, Haibo Wang","doi":"10.1186/s42825-025-00193-x","DOIUrl":"10.1186/s42825-025-00193-x","url":null,"abstract":"<div><p>Traumatic wounds are the prevalent scenarios encountered in battleground and emergency rooms. The rapid and effective hemostasis is imperative for life saving in these scenarios, for which the development of high-efficiency and biocompatible hemostatic materials is essential. Due to its excellent hemostatic property and biocompatibility, collagen has emerged as an ideal component of hemostatic materials. Furthermore, the properties of collagen-based hemostatic materials could be improved by the integration of other biomacromolecules, such as alginate, cellulose derivatives, and chitosan derivatives. Therefore, more and more novel hemostatic materials with exceptional hemostatic properties have been developed. This review aims to overview recent progress of collagen-based hemostatic materials. Firstly, the hemostatic mechanism of collagen was introduced. Secondly, various forms of collagen-based hemostatic materials, such as hydrogels, sponges, and powders, were highlighted. Thirdly, composite hemostatic materials of collagen and other biomacromolecules were overviewed. Finally, the outlook of collagen-based hemostatic materials was discussed.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":640,"journal":{"name":"Journal of Leather Science and Engineering","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://JLSE.SpringerOpen.com/counter/pdf/10.1186/s42825-025-00193-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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