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Photosynthesis Drives the Motion of Bio‐nanomotors 光合作用驱动生物纳米马达的运动
Pub Date : 2020-04-20 DOI: 10.1002/aisy.202000028
M. Mathesh, D. Wilson
Autonomous nanomotors have become the new paradigm for current research as they are expected to shift the momentum in the development of next‐generation technologies. However, there is a grand challenge in gaining control over the nanomotors’ motion, speed, directionality, and using biocompatible fuels to power them. Currently, light is recognized for powering micromotors with advancement in using visible light for driving motion at the nanoscale regime. In this context, micron‐scaled motors are fabricated but they contain metal surfaces and fabrication is quite laborious. Herein, encapsulation of plant organelles into supramolecular assemblies for active motion is conducted to fabricate bio‐nanomotors, utilizing the natural photosynthesis process for powering motion at the nanoscale. The oxygen produced by the water‐splitting reaction by plant organelles in visible light and the photophoresis effect due to the transparent nature of the supramolecular assembly are the main driving forces for bio‐nanomotors. The bio‐nanomotors are observed to have propelled motion with speed reaching up to 120.42 ± 12 μm s−1, together with on‐demand reversible on/off motion and real‐time control over change in directionality at the nanoscale. The observed results shift the momentum toward harnessing energy from natural processes to power nanosystems for varied applications.
自主纳米电机已经成为当前研究的新范式,因为它们有望改变下一代技术发展的势头。然而,在控制纳米马达的运动、速度、方向性和使用生物相容燃料为它们提供动力方面存在着巨大的挑战。目前,光被认为是驱动微电机的动力,在纳米尺度下使用可见光驱动运动。在这种情况下,微米级电机被制造出来,但它们含有金属表面,制造起来相当费力。在此,将植物细胞器封装成用于主动运动的超分子组件来制造生物纳米马达,利用自然光合作用过程为纳米级运动提供动力。植物细胞器在可见光下的水分解反应所产生的氧气以及超分子组装的透明性质所产生的光致导入效应是生物纳米马达的主要驱动力。研究人员观察到,生物纳米马达的推进运动速度可达120.42±12 μm s - 1,同时具有随需可逆的开/关运动和对纳米级方向变化的实时控制。观察到的结果改变了利用自然过程中的能量为各种应用的纳米系统提供动力的势头。
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引用次数: 7
Modular Soft Robotics: Modular Units, Connection Mechanisms, and Applications 模块化软机器人:模块化单元、连接机制和应用
Pub Date : 2020-04-14 DOI: 10.1002/aisy.201900166
Chao Zhang, Pingan Zhu, Yangqiao Lin, Zhongdong Jiao, J. Zou
A state‐of‐the‐art review of the modular soft robots (MSRs) is presented, with an outlook on the challenges and future directions of intelligent MSRs. In contrast to conventional robots composed of rigid materials, soft robots made from soft materials offer remarkable advantages in achieving various adaptive locomotion, manipulating delicate objects, providing safe human–robot interaction and adapting to confined environments due to their excellent compliance and adaptability, which have the potential to be widely used in numerous applications such as medical, exploration and rescue devices, etc. Unlike fixed‐morphology soft robots, modularization of soft robots is a low‐cost and rapid strategy that enables them to adapt to changing tasks and environments by rearranging the connectivity of module units and attain complex functionalities such as self‐assembly, self‐repair, or self‐replication. Although MSRs exhibit many advantages, they are still in the nascent stage with plenty of challenges. Herein, first the materials, fabrication, actuation, sensor, and control of various modular units in MSRs are introduced. Then, some main connection methods between modular units are summarized. Finally, the applications, challenges, and developing directions of intelligent MSRs are discussed.
介绍了模块化软机器人(msr)的最新进展,并展望了智能msr的挑战和未来方向。与传统的刚性材料组成的机器人相比,由软材料制成的软机器人由于其优异的顺应性和适应性,在实现各种自适应运动、操纵精细物体、提供安全的人机交互和适应有限环境方面具有显著的优势,在医疗、勘探和救援设备等众多应用中具有广泛的应用潜力。与固定形态的软机器人不同,软机器人的模块化是一种低成本和快速的策略,通过重新安排模块单元的连接,使它们能够适应不断变化的任务和环境,并获得复杂的功能,如自组装、自我修复或自我复制。尽管msr表现出许多优势,但它仍处于起步阶段,面临着许多挑战。本文首先介绍了msr中各种模块单元的材料、制造、驱动、传感器和控制。然后,总结了模块化单元之间的主要连接方法。最后讨论了智能msr的应用、面临的挑战和发展方向。
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引用次数: 45
Recent Progress in Synaptic Devices Based on 2D Materials 基于二维材料的突触器件研究进展
Pub Date : 2020-04-14 DOI: 10.1002/aisy.201900167
Linfeng Sun, Wei Wang, Heejun Yang
Diverse synaptic plasticity with a wide range of timescales in biological synapses plays an important role in memory, learning, and various signal processing with exceptionally low power consumption. Emulating biological synaptic functions by electric devices for neuromorphic computation has been considered as a way to overcome the traditional von Neumann architecture in which separated memory and information processing units require high power consumption for their functions. Synaptic devices are expected to conduct complex signal processing such as image classification, decision‐making, and pattern recognition in artificial neural networks. Among various materials and device architectures for synaptic devices, 2D materials and their van der Waals (vdW) heterostructures have been attracting tremendous attention from researchers based on their capacity to mimic unique synaptic plasticity for neuromorphic computing. Herein, the basic operations of biological synapses and physical properties of 2D materials are discussed, and then 2D materials and their vdW heterostructures for advanced synaptic operations with novel working mechanisms are reviewed. In particular, there is a focus on how to design synaptic devices with the vdW structures in terms of critical 2D materials and their limitations, providing insight into the emerging synaptic device systems and artificial neural networks with 2D materials.
生物突触具有多种时间尺度的突触可塑性,在记忆、学习和各种信号处理中发挥着重要作用,且功耗极低。利用电子设备模拟生物突触功能进行神经形态计算被认为是克服传统冯·诺伊曼架构的一种方法,在传统架构中,分离的存储和信息处理单元需要高功耗才能实现其功能。突触装置有望在人工神经网络中进行复杂的信号处理,如图像分类、决策和模式识别。在各种用于突触器件的材料和器件结构中,二维材料及其范德华异质结构(vdW)由于其模拟神经形态计算的独特突触可塑性的能力而引起了研究人员的极大关注。本文首先讨论了生物突触的基本操作和二维材料的物理性质,然后综述了二维材料及其具有新型工作机制的先进突触操作的vdW异质结构。特别是,重点关注如何在关键的2D材料及其局限性方面设计具有vdW结构的突触器件,为新兴的2D材料突触器件系统和人工神经网络提供见解。
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引用次数: 44
Emerging Micro/Nanomotor‐Based Platforms for Biomedical Therapy 新兴的微/纳米生物医学治疗平台
Pub Date : 2020-03-29 DOI: 10.1002/aisy.201900081
Zhen Wang, Yingfeng Tu, Yongming Chen, F. Peng
Highly efficient and versatile natural motors play a pivotal role in biological processes. Inspired by these biological motors, researchers developed their synthetic counterparts that can convert various energies into locomotion. With the potential to revolutionize the biomedical treatment process, these micro/nanomotors have been attracting a booming research enthusiasm since the birth of the first micro/nanomotor 15 years ago (since 2004). First, typical motion mechanisms are elucidated and a detailed comparison is provided regarding their efficiency in a biological context. Next, cutting‐edge proof‐of‐concept biomedical applications of the motors are overviewed, including on‐demand drug dispensing, cell transporting, and precise microsurgery. Current achievements and remaining bottlenecks are discussed, to spur more collaboration among chemistry, nanoengineering, and the biomedical fields. With increasing attention and continuing innovation of the field, clinical translation of micro/nanomotors is possible in the next 15 years.
高效、多用途的天然马达在生物过程中发挥着关键作用。受这些生物马达的启发,研究人员开发了能够将各种能量转化为运动的合成马达。自15年前(自2004年以来)第一台微/纳米马达诞生以来,这些微/纳米马达具有彻底改变生物医学治疗过程的潜力,一直吸引着蓬勃发展的研究热情。首先,阐明了典型的运动机制,并就其在生物学背景下的效率进行了详细的比较。接下来,概述了电机的尖端生物医学应用,包括按需药物分配,细胞运输和精确的显微手术。讨论了当前的成就和仍然存在的瓶颈,以促进化学、纳米工程和生物医学领域之间的更多合作。随着人们对该领域的关注和不断创新,在未来15年内,微/纳米马达的临床转化是可能的。
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引用次数: 8
3D Assembly of Graphene Nanomaterials for Advanced Electronics 用于先进电子器件的石墨烯纳米材料的3D组装
Pub Date : 2020-03-27 DOI: 10.1002/aisy.201900151
H. Ferrand, Sakineh Chabi, S. Agarwala
Since the discovery of electricity and the creation of the first transistors two centuries ago, the field of electronics has evolved rapidly to become omnipresent. Today, electronic devices are challenged by new demands in function and performance: they are expected to be lightweight, highly efficient, flexible, smart, implantable, and so on. To meet these demands, the materials and components in devices need to be carefully selected and assembled together. In this regard, the controlled assembly of 3D graphene structures holds tremendous potential to achieve such levels of multifunctionality and outstanding properties. Advanced processing approaches, such as 3D printing, allow the fabrication of a variety of 3D graphene–based materials that present outstanding properties and a high degree of multifunctionality. Herein, the recent progress in the fabrication of graphene‐based devices for advanced electronics using controlled assembly is reported. The benefits of controlling the microstructure of graphene nanomaterials for enhanced properties and functionalities are highlighted, and the various fabrication methods and their implications on the organization of materials are reviewed, as well as selected electrical devices. The approaches described here are opening up new avenues for the fabrication of health or structural monitoring devices, autonomous machines, and interconnected objects.
自从两个世纪前发现电和制造出第一批晶体管以来,电子学领域迅速发展,变得无所不在。今天,电子设备在功能和性能方面面临着新的要求:它们被期望是轻量化、高效、柔性、智能、可植入等。为了满足这些要求,设备中的材料和组件需要仔细选择并组装在一起。在这方面,3D石墨烯结构的受控组装具有巨大的潜力,可以实现如此多的功能和卓越的性能。先进的加工方法,如3D打印,可以制造出各种3D石墨烯基材料,这些材料具有出色的性能和高度的多功能。本文报道了利用控制组装技术制造先进电子器件的石墨烯基器件的最新进展。强调了控制石墨烯纳米材料的微观结构以增强其性能和功能的好处,并回顾了各种制造方法及其对材料组织的影响,以及选择的电气设备。本文描述的方法为健康或结构监测设备、自主机器和互联对象的制造开辟了新的途径。
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引用次数: 6
Driving Smart Molecular Systems by Artificial Molecular Machines 用人工分子机器驱动智能分子系统
Pub Date : 2020-03-27 DOI: 10.1002/aisy.201900169
Zhao-Tao Shi, Qi Zhang, H. Tian, Da‐Hui Qu
Biomolecular machines are widely present in nature, especially in complex living organisms, and are involved in important biological processes. Inspired by nature and increasingly mature synthetic technologies, a series of artificial molecular machines (AMMs) that exhibit similar processes and functions as biomolecular counterparts have been developed, and to date, some dramatic achievements have been obtained. Herein, the use of AMMs in smart systems and materials with controllable regulations and interesting functions are summarized, presenting the specific micro‐ to macroscale applications in solid surface modification, transmembrane transport, smart catalysts, liquid crystals, artificial molecular muscles, and stimuli‐responsive polymers. The challenges of developing novel complex AMMs with intelligent functions are discussed, and some potential solutions are proposed.
生物分子机器广泛存在于自然界,特别是复杂的生物体中,并参与重要的生物过程。受大自然和日益成熟的合成技术的启发,一系列具有与生物分子类似的过程和功能的人工分子机器(AMMs)已经被开发出来,并取得了一些令人瞩目的成就。本文总结了amm在智能系统和具有可控调节和有趣功能的材料中的应用,介绍了在固体表面改性、跨膜运输、智能催化剂、液晶、人工分子肌肉和刺激响应聚合物等微观到宏观尺度上的具体应用。讨论了开发具有智能功能的新型复杂机械臂所面临的挑战,并提出了一些可能的解决方案。
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引用次数: 12
From Bit to Bedside: A Practical Framework for Artificial Intelligence Product Development in Healthcare 从比特到床边:医疗保健领域人工智能产品开发的实用框架
Pub Date : 2020-03-23 DOI: 10.1002/aisy.202000052
David C. Higgins, V. Madai
Artificial intelligence (AI) in healthcare holds great potential to expand access to high‐quality medical care, while reducing systemic costs. Despite hitting headlines regularly and many publications of proofs‐of‐concept, certified products are failing to break through to the clinic. AI in healthcare is a multiparty process with deep knowledge required in multiple individual domains. A lack of understanding of the specific challenges in the domain is the major contributor to the failure to deliver on the big promises. Herein, a “decision perspective” framework for the development of AI‐driven biomedical products from conception to market launch is presented. The framework highlights the risks, objectives, and key results which are typically required to navigate a three‐phase process to market‐launch of a validated medical AI product. Clinical validation, regulatory affairs, data strategy, and algorithmic development are addressed. The development process proposed for AI in healthcare software strongly diverges from modern consumer software development processes. Key time points to guide founders, investors, and key stakeholders throughout the process are highlighted. This framework should be seen as a template for innovation frameworks, which can be used to coordinate team communications and responsibilities toward a viable product development roadmap, thus unlocking the potential of AI in medicine.
人工智能(AI)在医疗保健领域具有巨大的潜力,可以扩大获得高质量医疗服务的机会,同时降低系统成本。尽管经常登上头条新闻和许多出版物的概念证明,认证产品未能突破到临床。医疗保健中的人工智能是一个多方过程,在多个单独的领域需要深入的知识。缺乏对领域中具体挑战的理解是无法实现重大承诺的主要原因。本文提出了一个“决策视角”框架,用于开发人工智能驱动的生物医学产品,从概念到市场投放。该框架强调了风险、目标和关键结果,这些通常是引导经过验证的医疗人工智能产品进入市场的三个阶段过程所必需的。临床验证,法规事务,数据策略和算法开发的解决方案。医疗保健软件中人工智能的开发过程与现代消费者软件开发过程有很大的不同。重点介绍了在整个过程中指导创始人、投资者和主要利益相关者的关键时间点。该框架应被视为创新框架的模板,可用于协调团队沟通和责任,以制定可行的产品开发路线图,从而释放人工智能在医学中的潜力。
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引用次数: 44
Hydrogel Actuator with a Built‐In Stimulator Using Liquid Metal for Local Control 水凝胶致动器,内置刺激器,使用液态金属进行局部控制
Pub Date : 2020-03-18 DOI: 10.1002/aisy.202000008
Ken Matsubara, Daiki Tachibana, R. Matsuda, H. Onoe, O. Fuchiwaki, H. Ota
Hydrogel actuators, comprising gels that convert external stimuli into mechanical motion for actuation, are attracting attention for their promising applications, such as in robotics. The driving force is the absorption or release of water or another solvent, which results in swelling and shrinking motions, leading in turn to more complex functionalities. However, practical hydrogel actuators that can be controlled locally, such as ones that allow local actuation around the joints in rigid‐bodied robots, do not exist. Herein, the driving target of a thermo‐responsive hydrogel, poly(N‐isopropyl acrylamide), is integrated with the stimulation module using a liquid metal. The stimulation module provides heat as an external stimulus to the hydrogel actuator. The motion of the actuator is triggered by the heat supplied by an ultrasoft hydrogel coil, with liquid metal surrounding the driving target. The heat generated by current flowing through the liquid metal changes the temperature only around the desired part of the actuator, which enables the electrical control of an individual part of the hydrogel actuator. The concept of integrating the driving target and stimulator is expected to facilitate functional movement of actuators and expand the range of potential applications of hydrogels.
水凝胶致动器,包括将外部刺激转化为机械运动的凝胶,因其在机器人等领域的应用前景而受到关注。驱动力是水或其他溶剂的吸收或释放,这导致膨胀和收缩运动,进而导致更复杂的功能。然而,可以局部控制的实用水凝胶致动器,例如在刚体机器人的关节周围允许局部驱动的水凝胶致动器,并不存在。在这里,热响应水凝胶的驱动目标,聚(N -异丙基丙烯酰胺),使用液态金属与刺激模块集成在一起。刺激模块提供热量作为水凝胶致动器的外部刺激。驱动器的运动是由一个超软水凝胶线圈提供的热量触发的,驱动目标周围是液态金属。流经液态金属的电流产生的热量仅改变致动器所需部分周围的温度,从而实现对水凝胶致动器单个部分的电气控制。将驱动目标和刺激器集成的概念有望促进执行器的功能运动,并扩大水凝胶的潜在应用范围。
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引用次数: 12
3D‐Printed Microrobots with Integrated Structural Color for Identification and Tracking 具有集成结构颜色的3D打印微型机器人,用于识别和跟踪
Pub Date : 2020-03-05 DOI: 10.1002/aisy.201900147
Cara A. Koepele, M. Guix, Chenghao Bi, G. Adam, D. Cappelleri
The implementation of two‐photon polymerization (TPP) in the microrobotics community has permitted the fabrication of complex 3D structures at the microscale, creating novel platforms with potential biomedical applications for minimizing procedure invasiveness and diagnosis accuracy. Although advanced functionalities for manipulation and drug delivery tasks have been explored, one remaining challenge is achieving improved visualization, identification, and accurate closed‐loop control of microscale robots. To enable this, distinguishable identifying and trackable features must be included on the microrobot. Toward this end, the construction of micro‐ and nanoscale patterns using TPP is demonstrated for the first time on microrobot surfaces with the intent of mimicking color‐expressing nanostructures present on beetles or butterflies. The patterns provide identification and tracking targets due to their vivid color expression under visible light. Helical and rectangular microrobots are designed with the topical patterns and further functionalized with magnetic materials to be externally actuated by magnetic fields. Vision‐based tracking of a 20 μm × 30 μm colored feature on a 100 μm‐long helical microrobot using a fixed angular position light source during microrobotic motion is shown. This versatile structural color patterning approach shows great potential for the visual differentiation of various microrobots and tracking for improved closed‐loop control.
双光子聚合(TPP)技术在微型机器人领域的应用使得在微观尺度上制造复杂的3D结构成为可能,创造了具有潜在生物医学应用的新平台,以最大限度地减少手术侵入性和诊断准确性。尽管已经探索了用于操作和给药任务的先进功能,但仍然存在的挑战是实现改进的可视化、识别和精确的微型机器人闭环控制。为了实现这一点,微型机器人必须具有可区分的识别和可跟踪功能。为此,首次在微型机器人表面上展示了使用TPP构建微纳米尺度图案,目的是模仿甲虫或蝴蝶上存在的表达颜色的纳米结构。这些图案在可见光下表现出鲜明的色彩,为识别和跟踪目标提供了便利。设计了螺旋形和矩形微型机器人,并利用磁场驱动的磁性材料进一步实现了其功能。研究了在100 μm长螺旋微机器人运动过程中,使用固定角位置光源对20 μm × 30 μm彩色特征的视觉跟踪。这种多用途的结构颜色图案方法在各种微型机器人的视觉区分和改进闭环控制的跟踪方面显示出巨大的潜力。
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引用次数: 28
Machine Learning for Soft Robotic Sensing and Control 软机器人传感与控制中的机器学习
Pub Date : 2020-03-03 DOI: 10.1002/aisy.201900171
Keene Chin, T. Hellebrekers, C. Majidi
Herein, the progress of machine learning methods in the field of soft robotics, specifically in the applications of sensing and control, is outlined. Data‐driven methods such as machine learning are especially suited to systems with governing functions that are unknown, impractical or impossible to represent analytically, or computationally intractable to integrate into real‐world solutions. Function approximation with careful formulation of the machine learning architecture enables the encoding of dynamic behavior and nonlinearities, with the added potential to address hysteresis and nonstationary behavior. Supervised learning and reinforcement learning in simulation and on a wide variety of physical robotic systems have shown promising results for the use of empirical data‐driven methods as a solution to contemporary soft robotics problems.
在此,概述了机器学习方法在软机器人领域的进展,特别是在传感和控制方面的应用。数据驱动的方法,如机器学习,特别适合于具有未知、不切实际或不可能分析表示的控制功能的系统,或者难以计算地集成到现实世界的解决方案中。通过仔细制定机器学习架构的函数近似,可以对动态行为和非线性进行编码,并具有解决滞后和非平稳行为的附加潜力。在模拟和各种物理机器人系统上的监督学习和强化学习已经显示出有希望的结果,使用经验数据驱动的方法作为当代软机器人问题的解决方案。
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引用次数: 103
期刊
Advanced Intelligent Systems
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