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Magnetic Mobile Microrobots for Upstream and Downstream Navigation in Biofluids with Variable Flow Rate 用于可变流量生物流体上下游导航的磁性移动微型机器人
Pub Date : 2022-03-06 DOI: 10.1002/aisy.202100266
Zehao Wu, Yuting Zhang, Nana Ai, Haoran Chen, Wei Ge, Qingsong Xu
Magnetic mobile microrobots navigating biofluids with both upstream and downstream locomotion provide a promising solution to targeted drug delivery for precision medicine. However, the biofluid environment in blood vessels is complicated due to variations in flow rate and direction. It is still unknown how to make magnetic microrobots resist the variable flow rate in biofluids with both upstream and downstream locomotion. Herein, magnetic microrobots with various shapes and sizes have been controlled to navigate diverse biofluids under different flow rates and directions. Simulation and experimental studies have been conducted to analyze the influences of microrobot size and shape on translational velocity in confined microchannels filled with biofluids. A strategy is proposed to choose the optimized parameters of rotating magnetic field actuation for precise delivery of microrobots in a microfluidic chip, which contains a complex biofluid environment with variable flow rate and direction. The results are validated using various microrobots navigating the microfluidic chip and the yolks of zebrafish larvae in vivo. This work provides a guideline for selecting desirable microrobot dimensions and magnetic field actuation parameters for controllable navigation of magnetic mobile microrobots in complex biofluid flows.
磁性移动微型机器人在生物流体中进行上游和下游运动,为精准医疗的靶向药物递送提供了一个有前途的解决方案。然而,由于血流速率和方向的变化,血管内的生物流体环境是复杂的。如何使磁性微型机器人能够抵抗生物流体中上下游运动的可变流速,目前尚不清楚。在此,磁性微机器人具有不同的形状和大小,已被控制以不同的流速和方向在不同的生物流体中航行。通过仿真和实验研究,分析了微机器人尺寸和形状对充满生物流体的密闭微通道中移动速度的影响。针对微流控芯片中具有可变流速和方向的复杂生物流体环境,提出了一种选择旋转磁场驱动参数的策略,以实现微机器人在微流控芯片中的精确递送。利用各种微型机器人导航微流控芯片和斑马鱼幼虫的蛋黄在体内验证了结果。该研究为在复杂生物流体流动中选择合适的微机器人尺寸和磁场驱动参数,实现磁性移动微机器人的可控导航提供了指导。
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引用次数: 19
An Individually Controlled Multitined Expandable Electrode Using Active Cannula‐Based Shape Morphing for On‐Demand Conformal Radiofrequency Ablation Lesions 一种单独控制的多层可扩展电极,使用基于主动套管的形状变形,用于按需共形射频消融病变
Pub Date : 2022-01-26 DOI: 10.1002/aisy.202100262
Zhiping Chai, L. Lyu, Menghao Pu, Xianwen Chen, Jiaqi Zhu, Huageng Liang, Han Ding, Zhigang Wu
Being minimally invasive and highly effective, radiofrequency ablation (RFA) is widely used for small‐sized malignant tumor treatment. However, in clinical practice, a large number of tumors are found in irregular shape, while the current RFA devices are hard to control the morphologic appearance of RFA lesions on demand, which usually ends up with unnecessarily excessive tissue ablation and subsequently often brings irreversible damage to the organs’ functions. Herein, active cannulas for each of the individually controlled subelectrodes to achieve an on‐demand shape morphing and thus conformal RFA lesion are introduced. The target shape as well as the length of inserted subelectrodes can be precisely controlled by tuning the active stylets and cannulas. What's more, owing to independent movement and energy control of each subelectrodes, the electrode is shown to be not only efficient enough to accomplish accurate trajectory control to target tissue in a single insertion, but also adaptive enough to ablate target tissues with diverse morphologic appearances and locations. On‐demand conformal ablation of target tissue is demonstrated as well under the guidance of ultrasound imaging with the device. Potentially, the RFA electrode is a promising minimally invasive treatment of malignant tumors in future clinical practice. An interactive preprint version of the article can be found at: https://www.authorea.com/doi/full/10.22541/au.164019293.38729522.
射频消融术(RFA)具有微创和高效的特点,被广泛应用于小型恶性肿瘤的治疗。然而,在临床实践中,大量肿瘤呈不规则形状,而目前的RFA设备难以按需控制RFA病变的形态外观,往往导致不必要的过度组织消融,并对器官功能带来不可逆的损害。本文介绍了用于每个单独控制的亚电极的主动套管,以实现按需形状变形,从而实现适形RFA病变。目标的形状以及插入的亚电极的长度可以通过调整活动针和套管来精确控制。此外,由于每个亚电极的独立运动和能量控制,电极不仅具有足够的效率,可以在一次插入中实现对目标组织的精确轨迹控制,而且具有足够的适应性,可以消融具有不同形态外观和位置的目标组织。在该设备的超声成像指导下,也演示了对目标组织的按需适形消融。在未来的临床实践中,RFA电极是一种很有前途的恶性肿瘤微创治疗方法。文章的交互式预印本可在https://www.authorea.com/doi/full/10.22541/au.164019293.38729522上找到。
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引用次数: 2
Dimensions of Smart Additive Manufacturing 智能增材制造的维度
Pub Date : 2021-12-01 DOI: 10.1002/aisy.202100240
Keith A. Brown, Grace X. Gu
Additive manufacturing (AM) has matured in parallel with advances in computation. This is not a coincidence as taking advantage of the structural freedom afforded by AM requires detailed calculations and an ability to design and process complex structures in three dimensions. However, the ability to program AM systems is not the only way in which computation, and more recently machine learning, have impacted AM as a field. In fact, recent years have seen a number of innovations in AM that have endowed the process with varying degrees of ‘intelligence’ in distinct ways. While many of these are connected, several of these approaches to smart AM are wholly distinct in that they advance different aspects of the state-of-the-art. Our goal in this editorial is to highlight three such dimensions of intelligence in AM and connect them to articles in this special issue of Advanced Intelligent Systems that discuss innovations along these dimensions. These dimensions include advances in the materials and structures produced by AM to make them smarter or more functional, advances in processing to produce better and more reliable products, and advances in using AM as an ecosystem that is more agile and capable than traditional manufacturing (Figure 1).
增材制造(AM)随着计算技术的进步而成熟。这并非巧合,因为利用增材制造提供的结构自由度需要详细的计算以及在三维空间中设计和加工复杂结构的能力。然而,对AM系统进行编程的能力并不是计算和最近的机器学习对AM领域产生影响的唯一方式。事实上,近年来在AM领域出现了许多创新,这些创新以不同的方式赋予了该过程不同程度的“智能”。虽然其中许多是相互关联的,但智能AM的一些方法是完全不同的,因为它们推进了最先进技术的不同方面。我们这篇社论的目标是强调增材制造中智能的三个维度,并将它们与本期《高级智能系统》特刊中讨论这些维度创新的文章联系起来。这些方面包括增材制造生产的材料和结构的进步,使其更智能或更功能,加工的进步,以生产更好、更可靠的产品,以及使用增材制造作为一个比传统制造更灵活、更有能力的生态系统的进步(图1)。
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引用次数: 2
Strengthening the Sustainability of Additive Manufacturing through Data‐Driven Approaches and Workforce Development 通过数据驱动方法和劳动力发展加强增材制造的可持续性
Pub Date : 2021-11-07 DOI: 10.1002/aisy.202100069
Tianjiao Li, J. Yeo
The additive manufacturing (AM) industry is rapidly developing and expanding, thereby becoming an important and integral component of the digital revolution in manufacturing practices. While the engineering aspects of AM are under intensive research, there still remain many chances to strengthen the sustainability of additive manufacturing (SAM). Cogently increasing the AM community's attention to SAM is vital for developing the AM industry sustainably from the bottom up. The digital nature of AM provides new opportunities for acquiring, storing, and utilizing data to strengthen SAM through data‐driven approaches. Herein, spotlight on SAM is shone upon and it is placed on a more concrete footing. The corresponding advances in data‐driven methods that can strengthen SAM are featured, such as optimizing designs for AM, reducing material waste, and developing databases. How the AM workforce can be developed and grown as a collaboration between the industry, government, and academia to extensively harness the full potential of AM as well as mitigate its adversarial social impact is discussed. Finally, several critical digital techniques that have the potential to further strengthen SAM in the factory of the future, including hybrid manufacturing, Internet of Things, and machine learning and artificial intelligence, are highlighted.
增材制造(AM)行业正在迅速发展和扩大,从而成为制造实践中数字革命的重要组成部分。虽然增材制造的工程方面正在深入研究,但仍有许多机会加强增材制造(SAM)的可持续性。切实提高AM社区对SAM的关注对于AM行业自下而上的可持续发展至关重要。AM的数字特性为获取、存储和利用数据提供了新的机会,通过数据驱动的方法来加强SAM。在这里,对地对空导弹的关注被放在了一个更具体的基础上。数据驱动方法的相应进展可以加强SAM,如优化AM设计,减少材料浪费和开发数据库。讨论了如何通过行业、政府和学术界之间的合作,开发和发展增材制造劳动力,以广泛利用增材制造的全部潜力,并减轻其对社会的不利影响。最后,重点介绍了几种有可能进一步加强未来工厂SAM的关键数字技术,包括混合制造、物联网、机器学习和人工智能。
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引用次数: 7
Extrapolative Bayesian Optimization with Gaussian Process and Neural Network Ensemble Surrogate Models 高斯过程和神经网络集成代理模型的外推贝叶斯优化
Pub Date : 2021-11-01 DOI: 10.1002/aisy.202170077
Y. Lim, Chee Koon Ng, U. S. Vaitesswar, K. Hippalgaonkar
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引用次数: 0
In Situ Nondestructive Fatigue‐Life Prediction of Additive Manufactured Parts by Establishing a Process–Defect–Property Relationship 建立工艺-缺陷-性能关系的增材制造零件原位无损疲劳寿命预测
Pub Date : 2021-10-29 DOI: 10.1002/aisy.202000268
Seyyed Hadi Seifi, A. Yadollahi, Wenmeng Tian, H. Doude, V. H. Hammond, L. Bian
The presence of process‐induced internal defects (i.e., pores, microcracks, and lack‐of‐fusions) significantly deteriorates the structural durability of parts fabricated by additive manufacturing. However, traditional defects characterization techniques, such as X‐ray CT and ultrasonic scanning, are costly and time‐consuming. There is a research gap in the nondestructive evaluation of fatigue performance directly from the process signature of laser‐based additive manufacturing processes. Herein, a novel two‐phase modeling methodology is proposed for fatigue life prediction based on in situ monitoring of thermal history. Phase (I) includes a convolutional neural network designed to detect the relative size of the defects (i.e., small gas pores and large lack‐of‐fusions) by leveraging processed thermal images. Subsequently, a fatigue‐life prediction model is trained in Phase (II) by incorporating the defect characteristics extracted from Phase (I) to evaluate the fatigue performance. Estimating defect characteristics from the in situ thermal history facilitates the fatigue predicting process.
过程引起的内部缺陷(即孔隙、微裂纹和缺乏熔合)的存在会显著降低增材制造制造的部件的结构耐久性。然而,传统的缺陷表征技术,如X射线CT和超声波扫描,既昂贵又耗时。直接从激光增材制造工艺特征对疲劳性能进行无损评价的研究还存在空白。本文提出了一种新的基于热历史现场监测的疲劳寿命预测的两相建模方法。阶段(I)包括一个卷积神经网络,旨在通过利用处理过的热图像来检测缺陷的相对大小(即小气孔和大缺乏熔合物)。随后,在阶段(II)中,通过结合从阶段(I)中提取的缺陷特征来训练疲劳寿命预测模型,以评估疲劳性能。从原位热历史中估计缺陷特征有助于疲劳预测过程。
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引用次数: 8
Manufacturing for the Masses: A Novel Concept for Consumer 3D Printer Networks in the Context of Crisis Relief 大众制造:危机救济背景下消费者3D打印机网络的新概念
Pub Date : 2021-09-29 DOI: 10.1002/aisy.202100121
B. Raeymaekers, K. Leang, M. Porfiri, Shenghan Xu
Local or national crises, such as natural disasters, major infrastructure failures, and pandemics, pose dire threats to manufacturing. The concept of a rideshare‐like distributed network of consumer‐type 3D printers is proposed to address the limited ability of the industrial base to quickly respond to abrupt changes in critical product demand or to disruptions in manufacturing and supply‐chain capacity. The technical challenges that prevent the implementation of such a network are discussed, including 1) remote qualification of 3D printers, 2) dynamic routing algorithms with reactive and predictive components, which take advantage of real‐time information about current events that may affect the network, and 3) performance evaluation of the network. Furthermore, a cyber‐infrastructure that enables autonomous operation and reconfiguration of the network to render it “crisis‐proof” by minimizing human involvement is introduced. The concept of a distributed network of consumer‐type 3D printers allows anyone with a 3D printer and access to the internet to manufacture critical supplies, triggered by actual and predicted customer demand. Beyond crisis relief, distributed networks of manufacturing assets have broad relevance, and they can establish a virtual marketplace to exchange manufacturing capacity. Thus, this future manufacturing platform has the potential to transform how to manufacture for the masses.
地方或国家危机,如自然灾害、重大基础设施故障和流行病,对制造业构成严重威胁。消费者型3D打印机的共享式分布式网络的概念被提出,以解决工业基地快速响应关键产品需求突变或制造和供应链能力中断的有限能力。本文讨论了阻碍这种网络实现的技术挑战,包括1)3D打印机的远程认证,2)具有响应性和预测性组件的动态路由算法,该算法利用了可能影响网络的当前事件的实时信息,以及3)网络的性能评估。此外,还介绍了一种网络基础设施,它可以实现网络的自主操作和重新配置,通过最大限度地减少人为参与,使其“防危机”。消费者型3D打印机分布式网络的概念允许任何拥有3D打印机并访问互联网的人制造关键物资,由实际和预测的客户需求触发。除了危机救济之外,制造资产的分布式网络具有广泛的相关性,它们可以建立一个虚拟市场来交换制造能力。因此,这个未来的制造平台有可能改变大众制造的方式。
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引用次数: 1
Fused Deposition Modeling‐Based 3D‐Printed Electrical Interconnects and Circuits 基于熔融沉积建模的3D打印电气互连和电路
Pub Date : 2021-09-27 DOI: 10.1002/aisy.202100102
Habib Nassar, R. Dahiya
Multimaterial 3D printing in electronics is expanding due to the ability to realize geometrically complex systems with simplified processes compared with conventional printed circuit board. Herein, the feasibility of using a copper‐based filament to realize 3D circuits with planar and vertical interconnections is presented. The resistivity of the tracks (1–3 mm wide) is studied with reference to printing parameters and orientation. Using lateral infill for 1 mm tracks offers lower resistance compared with longitudinal infill (≈75%). For wider tracks, the effect of infill orientation on resistance diminishes. The evaluation of tracks embedded in polylactic acid shows a drop in maximum current (to ≈11 mA) compared with exposed tracks (≈16 mA). There is no observed correlation between electrical performance and number of embedding layers. However, a significant correlation is observed between the tracks’ resistance and the amount of time the filament remains in the heated nozzle. This in‐depth study leads to optimum resolution to realize conductive tracks of 0.67 mm thickness and the first integration of fused deposition modeling (FDM)‐printed conductive traces with small‐outline integrated circuits to open a pathway for higher‐density 3D printed circuits. Finally, the transmission of digital data by a 3D printed circuit is demonstrated.
与传统印刷电路板相比,多材料3D打印在电子领域的应用正在扩大,因为它能够以简化的过程实现几何复杂的系统。本文提出了利用铜基灯丝实现平面和垂直连接的三维电路的可行性。参考打印参数和方向,研究了轨道(1 ~ 3mm宽)的电阻率。与纵向填充相比,使用横向填充1mm履带的阻力更低(≈75%)。对于较宽的轨道,填充方向对阻力的影响减小。对嵌入聚乳酸的磁道的评价表明,与暴露的磁道(≈16 mA)相比,最大电流(约11 mA)下降。没有观察到电性能与嵌入层数之间的相关性。然而,观察到轨道的电阻和灯丝在加热喷嘴中停留的时间之间存在显著的相关性。这项深入的研究为实现0.67 mm厚度的导电轨迹提供了最佳分辨率,并首次将熔融沉积建模(FDM)印刷导电轨迹与小轮廓集成电路集成在一起,为更高密度的3D打印电路开辟了道路。最后,通过3D打印电路演示了数字数据的传输。
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引用次数: 20
Energy‐Efficient Memristive Euclidean Distance Engine for Brain‐Inspired Competitive Learning 高效记忆欧几里得距离引擎,用于大脑启发的竞争性学习
Pub Date : 2021-09-07 DOI: 10.1002/aisy.202100114
Houji Zhou, Jia Chen, Yinan Wang, Sen Liu, Yi Li, Qingjiang Li, Qi Liu, Zhongrui Wang, Yuhui He, Hui Xu, X. Miao
Inspired by competitive rules of the nature, competitive learning contributes to the specialization of the human brain and the general creativity of mankind. However, the construction of hardware competitive learning neural network still faces great challenges due to the lack of an accurate distance computation method and a self‐adaptive in situ training scheme. Herein, a fully memristive Euclidean distance (ED) engine based on analog multiply‐accumulate operation in a 32 × 32 TiN/TaO x /HfO x /TiN 1T1R array is demonstrated. The dual‐layer devices perform multilevel modulation under the target‐aware programming method with excellent read linearity in a dynamic range of 10–100 μS. The ED calculation is verified experimentally on a test board with an O(1) temporal complexity. Furthermore, in situ training and offline inference schemes for competitive learning, based on the ED engine, are developed and the simulated results show comparable success rates with those obtained by the CPU‐based software. Compared with a state‐of‐the‐art RTX6000 GPU (0.5 TOPS W−1), the energy efficiency of competitive learning models on ED engines can yield 100× improvements by utilizing optimized memristive devices.
竞争性学习受自然界竞争规律的启发,有助于人类大脑的专业化和人类的普遍创造力。然而,由于缺乏精确的距离计算方法和自适应的原位训练方案,硬件竞争学习神经网络的构建仍然面临着很大的挑战。本文演示了一种基于32 × 32 TiN/TaO x /HfO x /TiN 1T1R阵列模拟乘法累加运算的全记忆性欧氏距离(ED)引擎。该双层器件在目标感知编程方法下进行多电平调制,在10-100 μS的动态范围内具有良好的读取线性度。在时间复杂度为0(1)的测试板上进行了实验验证。此外,基于ED引擎开发了用于竞争学习的现场训练和离线推理方案,仿真结果显示与基于CPU的软件获得的成功率相当。与最先进的RTX6000 GPU (0.5 TOPS W−1)相比,利用优化的记忆器件,ED发动机上的竞争学习模型的能源效率可以提高100倍。
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引用次数: 9
3D Propulsions of Rod‐Shaped Micropropellers 杆形微螺旋桨的三维推进
Pub Date : 2021-08-30 DOI: 10.1002/aisy.202100083
Yuan Zhang, Xiangkui Tan, Xiying Li, Pengyu Lv, Tian-Yun Huang, Jianying Yang, Huiling Duan
Untethered, magnetically driven microrobots have great potential in practical applications such as minimally invasive surgery. Microrods, also known as “nanowires,” are the most commonly used type of structure for microrobots due to the easy fabrication and promising functions. Driven by a uniform rotating magnetic field, microrods can perform a 2D movement with the assistance of a boundary surface, which severely limits the application of microrods in 3D spaces. Herein, an asymmetric structural design is proposed to construct rod‐shaped micropropellers that can achieve a surface‐free 3D propulsion. A theoretical model is formulated based on resistive force theory to investigate the dynamics of micropropellers. It is theoretically demonstrated and experimentally verified that the magnetic micropropeller can realize not only a 3D propulsion, but also multimodal locomotion to adapt to the environment. The work provides guidance for the design and optimization of autonomous micropropellers.
无系绳、磁力驱动的微型机器人在诸如微创手术等实际应用中具有巨大的潜力。微棒,也被称为“纳米线”,由于易于制造和有前途的功能,是微型机器人最常用的结构类型。在均匀旋转磁场的驱动下,微棒可以在边界表面的帮助下进行二维运动,这严重限制了微棒在三维空间中的应用。本文提出了一种非对称结构设计来构建杆状微螺旋桨,以实现无表面的三维推进。建立了基于阻力理论的微螺旋桨动力学模型。理论论证和实验验证了磁性微螺旋桨不仅可以实现三维推进,而且可以实现适应环境的多模式运动。研究结果对自主微螺旋桨的设计与优化具有指导意义。
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引用次数: 0
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Advanced Intelligent Systems
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