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Attention-Gated Graph Convolutions for Extracting Drug Interaction Information from Drug Labels. 从药物标签中提取药物相互作用信息的注意门控图卷积。
Pub Date : 2021-03-01 DOI: 10.1145/3423209
Tung Tran, Ramakanth Kavuluru, Halil Kilicoglu

Preventable adverse events as a result of medical errors present a growing concern in the healthcare system. As drug-drug interactions (DDIs) may lead to preventable adverse events, being able to extract DDIs from drug labels into a machine-processable form is an important step toward effective dissemination of drug safety information. Herein, we tackle the problem of jointly extracting mentions of drugs and their interactions, including interaction outcome, from drug labels. Our deep learning approach entails composing various intermediate representations, including graph-based context derived using graph convolutions (GCs) with a novel attention-based gating mechanism (holistically called GCA), which are combined in meaningful ways to predict on all subtasks jointly. Our model is trained and evaluated on the 2018 TAC DDI corpus. Our GCA model in conjunction with transfer learning performs at 39.20% F1 and 26.09% F1 on entity recognition (ER) and relation extraction (RE), respectively, on the first official test set and at 45.30% F1 and 27.87% F1 on ER and RE, respectively, on the second official test set. These updated results lead to improvements over our prior best by up to 6 absolute F1 points. After controlling for available training data, the proposed model exhibits state-of-the-art performance for this task.

医疗失误导致的可预防不良事件在医疗系统中引起了越来越多的关注。由于药物-药物相互作用(DDI)可能导致可预防的不良事件,能够将药物标签中的DDI提取成机器可处理的形式是有效传播药物安全信息的重要一步。在此,我们解决了从药物标签中联合提取药物及其相互作用的提及,包括相互作用结果的问题。我们的深度学习方法需要组合各种中间表示,包括使用图卷积(GC)和一种新的基于注意力的门控机制(整体称为GCA)导出的基于图的上下文,它们以有意义的方式组合在一起,共同预测所有子任务。我们的模型在2018 TAC-DDI语料库上进行了训练和评估。我们的GCA模型与迁移学习相结合,在第一个官方测试集上,在实体识别(ER)和关系提取(RE)上的表现分别为39.20%和26.09%,在第二个官方测试集中,在ER和RE上分别为45.30%和27.87%。这些更新的结果比我们之前的最佳成绩提高了6个绝对F1积分。在控制了可用的训练数据后,所提出的模型在这项任务中表现出了最先进的性能。
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引用次数: 3
Saliency-Aware Class-Agnostic Food Image Segmentation 显著性感知的食物图像分割
Pub Date : 2021-02-13 DOI: 10.1145/3440274
S. Yarlagadda, D. M. Montserrat, D. Güera, C. Boushey, D. Kerr, F. Zhu
Advances in image-based dietary assessment methods have allowed nutrition professionals and researchers to improve the accuracy of dietary assessment, where images of food consumed are captured using smartphones or wearable devices. These images are then analyzed using computer vision methods to estimate energy and nutrition content of the foods. Food image segmentation, which determines the regions in an image where foods are located, plays an important role in this process. Current methods are data dependent and thus cannot generalize well for different food types. To address this problem, we propose a class-agnostic food image segmentation method. Our method uses a pair of eating scene images, one before starting eating and one after eating is completed. Using information from both the before and after eating images, we can segment food images by finding the salient missing objects without any prior information about the food class. We model a paradigm of top-down saliency that guides the attention of the human visual system based on a task to find the salient missing objects in a pair of images. Our method is validated on food images collected from a dietary study that showed promising results.
基于图像的饮食评估方法的进步使营养专业人员和研究人员能够提高饮食评估的准确性,其中使用智能手机或可穿戴设备捕获所消耗食物的图像。然后使用计算机视觉方法对这些图像进行分析,以估计食物的能量和营养含量。食品图像分割在这一过程中起着重要作用,它确定了食品在图像中所处的区域。目前的方法依赖于数据,因此不能很好地概括不同的食物类型。为了解决这个问题,我们提出了一种与类别无关的食品图像分割方法。我们的方法使用一对进食场景图像,一个在开始进食前,一个在进食完成后。利用进食前和进食后的图像信息,我们可以在没有任何关于食物类别的先验信息的情况下,通过找到明显缺失的物体来分割食物图像。我们建立了一个自上而下的显著性范式,该范式引导人类视觉系统的注意力,基于在一对图像中找到显著缺失的物体的任务。我们的方法在一项饮食研究中收集的食物图像上得到了验证,结果很有希望。
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引用次数: 7
Selecting Treatment Effects Models for Domain Adaptation Using Causal Knowledge 利用因果知识选择领域适应的治疗效果模型
Pub Date : 2021-02-11 DOI: 10.1145/3587695
Trent Kyono, I. Bica, Z. Qian, M. van der Schaar
While a large number of causal inference models for estimating individualized treatment effects (ITE) have been developed, selecting the best one poses a unique challenge, since the counterfactuals are never observed. The problem is challenged further in the unsupervised domain adaptation (UDA) setting where we have access to labeled samples in the source domain but desire selecting an ITE model that achieves good performance on a target domain where only unlabeled samples are available. Existing selection techniques for UDA are designed for predictive models and are sub-optimal for causal inference because they (1) do not account for the missing counterfactuals and (2) only examine the discriminative density ratios between the input covariates in the source and target domain and do not factor in the model’s predictions in the target domain. We leverage the invariance of causal structures across domains to introduce a novel model selection metric specifically designed for ITE models under UDA. We propose selecting models whose predictions of the effects of interventions satisfy invariant causal structures in the target domain. Experimentally, our method selects ITE models that are more robust to covariate shifts on a variety of datasets, including estimating the effect of ventilation in COVID-19 patients.
虽然已经开发了大量用于估计个体化治疗效果(ITE)的因果推理模型,但选择最好的模型是一个独特的挑战,因为从来没有观察到反事实。在无监督域自适应(UDA)设置中,该问题受到了进一步的挑战,在该设置中,我们可以访问源域中的标记样本,但希望选择在只有未标记样本可用的目标域上实现良好性能的ITE模型。现有的UDA选择技术是为预测模型设计的,并且对于因果推断来说是次优的,因为它们(1)不考虑遗漏的反事实,并且(2)只检查源域和目标域中输入协变量之间的判别密度比,并且不考虑模型在目标域中的预测。我们利用因果结构跨领域的不变性,引入了一种专门为UDA下的ITE模型设计的新模型选择度量。我们建议选择对干预效果的预测满足目标域中不变因果结构的模型。在实验上,我们的方法选择了对各种数据集上的协变量变化更具鲁棒性的ITE模型,包括估计新冠肺炎患者通气的影响。
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引用次数: 4
Smartphone Sonar-Based Contact-Free Respiration Rate Monitoring 基于智能手机声纳的无接触呼吸速率监测
Pub Date : 2021-02-09 DOI: 10.1145/3436822
Xuyu Wang, Runze Huang, Chao Yang, S. Mao
Vital sign (e.g., respiration rate) monitoring has become increasingly more important because it offers useful clues about medical conditions such as sleep disorders. There is a compelling need for technologies that enable contact-free and easy deployment of vital sign monitoring over an extended period of time for healthcare. In this article, we present a SonarBeat system to leverage a phase-based active sonar to monitor respiration rates with smartphones. We provide a sonar phase analysis and discuss the technical challenges for respiration rate estimation utilizing an inaudible sound signal. Moreover, we design and implement the SonarBeat system, with components including signal generation, data extraction, received signal preprocessing, and breathing rate estimation with Android smartphones. Our extensive experimental results validate the superior performance of SonarBeat in different indoor environment settings.
生命体征(如呼吸频率)监测变得越来越重要,因为它为睡眠障碍等医疗状况提供了有用的线索。迫切需要能够在较长一段时间内实现无接触和轻松部署生命体征监测的技术。在本文中,我们介绍了一种SonarBeat系统,该系统利用基于相位的主动声呐来监测智能手机的呼吸速率。我们提供了声纳相位分析,并讨论了利用不可听声信号估计呼吸速率的技术挑战。此外,我们设计并实现了SonarBeat系统,包括信号生成、数据提取、接收信号预处理和呼吸频率估计等组件。我们的大量实验结果验证了SonarBeat在不同室内环境设置中的优越性能。
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引用次数: 12
Machine Learning for Sleep Apnea Detection with Unattended Sleep Monitoring at Home 在家进行无人值守睡眠监测的机器学习睡眠呼吸暂停检测
Pub Date : 2021-02-09 DOI: 10.1145/3433987
Stein Kristiansen, K. Nikolaidis, T. Plagemann, V. Goebel, G. Traaen, B. Øverland, L. Aakerøy, T. Hunt, J. P. Loennechen, S. Steinshamn, C. Bendz, O. Anfinsen, L. Gullestad, H. Akre
Sleep apnea is a common and strongly under-diagnosed severe sleep-related respiratory disorder with periods of disrupted or reduced breathing during sleep. To diagnose sleep apnea, sleep data are collected with either polysomnography or polygraphy and scored by a sleep expert. We investigate in this work the use of supervised machine learning to automate the analysis of polygraphy data from the A3 study containing more than 7,400 hours of sleep monitoring data from 579 patients. We conduct a systematic comparative study of classification performance and resource use with different combinations of 27 classifiers and four sleep signals. The classifiers achieve up to 0.8941 accuracy (kappa: 0.7877) when using all four signal types simultaneously and up to 0.8543 accuracy (kappa: 0.7080) with only one signal, i.e., oxygen saturation. Methods based on deep learning outperform other methods by a large margin. All deep learning methods achieve nearly the same maximum classification performance even when they have very different architectures and sizes. When jointly accounting for classification performance, resource consumption and the ability to achieve with less training data high classification performance, we find that convolutional neural networks substantially outperform the other classifiers.
睡眠呼吸暂停是一种常见且诊断严重不足的严重睡眠相关呼吸系统疾病,在睡眠期间呼吸会中断或减少。为了诊断睡眠呼吸暂停,通过多导睡眠图或多导睡眠描记术收集睡眠数据,并由睡眠专家进行评分。在这项工作中,我们研究了使用监督机器学习来自动分析A3研究中的测谎数据,该研究包含579名患者的7400多小时睡眠监测数据。我们对27个分类器和4个睡眠信号的不同组合的分类性能和资源使用进行了系统的比较研究。当同时使用所有四种信号类型时,分类器实现高达0.8941的准确度(kappa:0.07877),并且当仅使用一个信号(即氧饱和度)时,分类器达到高达0.8543的准确率(kappa:0.7080)。基于深度学习的方法在很大程度上优于其他方法。所有深度学习方法即使具有非常不同的架构和大小,也能实现几乎相同的最大分类性能。当综合考虑分类性能、资源消耗和用较少训练数据实现高分类性能的能力时,我们发现卷积神经网络显著优于其他分类器。
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引用次数: 14
Introduction to the Special Issue on the Wearable Technologies for Smart Health, Part 2 智能健康的可穿戴技术特刊简介(二
Pub Date : 2021-01-20 DOI: 10.1145/3442350
D. Kotz, G. Xing
Wearable health-tracking consumer products are gaining popularity, including smart watches, fitness trackers, smart clothing, and head-mounted devices. These wearable devices promise new opportunities for the study of health-related behavior, for tracking of chronic conditions, and for innovative interventions in support of health and wellness. Next-generation wearable technologies have the potential to transform today’s hospitalcentered healthcare practices into proactive, individualized care. Although it seems new technologies enter the marketplace every week, there is still a great need for research on the development of sensors, sensor-data analytics, wearable interaction modalities, and more. In this special issue, we sought to assemble a set of articles addressing novel computational research related to any aspect of the design or use of wearables in medicine and health, including wearable hardware design, AI and data analytics algorithms, human-device interaction, security/privacy, and novel applications. Here, in Part 2 of a two-part collection of articles on this topic, we are pleased to share four articles about the use of wearables for skill assessment, activity recognition, mood recognition, and deep learning. In the first article, Generalized and Efficient Skill Assessment from IMU Data with Applications in Gymnastics and Medical Training, Khan et al. propose a new framework for skill assessment that generalizes across application domains and can be deployed for different near-real-time applications. The effectiveness and efficiency of the proposed approach is validated in gymnastics and surgical skill training of medical students. In the next article, Privacy-preserving IoT Framework for Activity Recognition in Personal Healthcare Monitoring, Jourdan et al. propose a framework that uses machine learning to recognize the user activity, in the context of personal healthcare monitoring, while limiting the risk of users’ re-identification from biometric patterns that characterize an individual. Their solution trades off privacy and utility with a slight decrease of utility (9% drop in accuracy) against a large increase of privacy. Next, the article Perception Clusters: Automated Mood Recognition using a Novel Cluster-driven Modelling System proposes a mood-recognition system that groups individuals in “perception clusters” based on their physiological signals. This method can provide inference results that are more accurate than generalized models, without the need for the extensive training data necessary to build personalized models. In this regard, the approach is a compromise between generalized and personalized models for automated mood recognition (AMR). Finally, in an article about the Ensemble Deep Learning on Wearables Using Small Datasets, Ngu et al. describe an in-depth experimental study of Ensemble Deep Learning techniques on small time-series datasets generated by wearable devices, which is motivated by the fact that there
可穿戴健康跟踪消费产品越来越受欢迎,包括智能手表、健身追踪器、智能服装和头戴式设备。这些可穿戴设备为研究健康相关行为、跟踪慢性病以及支持健康和身心健康的创新干预措施提供了新的机会。下一代可穿戴技术有潜力将当今以医院为中心的医疗实践转变为积极主动的个性化护理。尽管似乎每周都有新技术进入市场,但仍然非常需要研究传感器、传感器数据分析、可穿戴交互模式等的开发。在本期特刊中,我们试图汇编一系列文章,阐述与可穿戴设备在医学和健康领域的设计或使用的任何方面相关的新计算研究,包括可穿戴硬件设计、人工智能和数据分析算法、人机交互、安全/隐私和新应用。在这篇由两部分组成的关于这个主题的文章集的第2部分中,我们很高兴分享四篇关于使用可穿戴设备进行技能评估、活动识别、情绪识别和深度学习的文章。在第一篇文章《IMU数据的通用高效技能评估及其在体操和医学训练中的应用》中,Khan等人提出了一种新的技能评估框架,该框架可跨应用领域进行通用,并可用于不同的近实时应用。该方法在医学生体操和外科技能训练中的有效性和有效性得到了验证。在下一篇文章《个人医疗保健监测中活动识别的隐私保护物联网框架》中,Jourdan等人提出了一个框架,该框架在个人医疗保健监控的背景下使用机器学习来识别用户活动,同时限制用户从个人特征的生物特征模式中重新识别的风险。他们的解决方案在隐私和实用性之间进行了权衡,实用性略有下降(准确率下降9%),而隐私却大幅增加。接下来,文章《感知集群:使用新型集群驱动建模系统的自动情绪识别》提出了一种情绪识别系统,该系统根据个体的生理信号将其分组为“感知集群”。该方法可以提供比广义模型更准确的推理结果,而不需要构建个性化模型所需的大量训练数据。在这方面,该方法是用于自动情绪识别(AMR)的通用模型和个性化模型之间的折衷。最后,在一篇关于使用小数据集的可穿戴设备集成深度学习的文章中,Ngu等人描述了在可穿戴设备生成的小时间序列数据集上集成深度学习技术的深入实验研究,其动机是没有公开可用的、大的、带注释的数据集可用于某些医疗保健应用的训练,例如实时跌倒检测。离线实验结果表明,在使用真实世界的用户反馈进行重新训练后,递归神经网络(RNN)模型的集合优于单个RNN模型,并在不减少大部分回忆的情况下实现了显著更高的精度。
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引用次数: 0
Data-driven Context Detection Leveraging Passively Sensed Nearables for Recognizing Complex Activities of Daily Living 数据驱动的上下文检测利用被动感知的近距物来识别日常生活中的复杂活动
Pub Date : 2021-01-04 DOI: 10.1145/3428664
A. Akbari, Reese Grimsley, R. Jafari
Wearable systems have unlocked new sensing paradigms in various applications such as human activity recognition, which can enhance effectiveness of mobile health applications. Current systems using wearables are not capable of understanding their surroundings, which limits their sensing capabilities. For instance, distinguishing certain activities such as attending a meeting or class, which have similar motion patterns but happen in different contexts, is challenging by merely using wearable motion sensors. This article focuses on understanding user's surroundings, i.e., environmental context, to enhance capability of wearables, with focus on detecting complex activities of daily living (ADL). We develop a methodology to automatically detect the context using passively observable information broadcasted by devices in users’ locale. This system does not require specific infrastructure or additional hardware. We develop a pattern extraction algorithm and probabilistic mapping between the context and activities to reduce the set of probable outcomes. The proposed system contains a general ADL classifier working with motion sensors, learns personalized context, and uses that to reduce the search space of activities to those that occur within a certain context. We collected real-world data of complex ADLs and by narrowing the search space with context, we improve average F1-score from 0.72 to 0.80.
可穿戴系统在人体活动识别等各种应用中开启了新的传感范式,可以提高移动医疗应用的有效性。目前使用可穿戴设备的系统无法理解周围环境,这限制了它们的传感能力。例如,仅仅使用可穿戴运动传感器,就很难区分具有相似运动模式但发生在不同环境中的某些活动,例如参加会议或上课。本文的重点是了解用户的周围环境,即环境上下文,以增强可穿戴设备的能力,重点是检测复杂的日常生活活动(ADL)。我们开发了一种方法来自动检测上下文使用被动可观察信息广播的设备在用户的地区。该系统不需要特定的基础设施或额外的硬件。我们开发了一种模式提取算法和上下文与活动之间的概率映射,以减少可能结果的集合。该系统包含一个与运动传感器一起工作的通用ADL分类器,学习个性化上下文,并使用该分类器将活动的搜索空间减少到在特定上下文中发生的活动。我们收集了复杂adl的真实世界数据,通过缩小搜索空间和上下文,我们将平均f1分数从0.72提高到0.80。
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引用次数: 1
A Survey of Challenges and Opportunities in Sensing and Analytics for Risk Factors of Cardiovascular Disorders. 心血管疾病风险因素传感与分析的挑战与机遇调查》。
Pub Date : 2021-01-01 Epub Date: 2020-12-30 DOI: 10.1145/3417958
Nathan C Hurley, Erica S Spatz, Harlan M Krumholz, Roozbeh Jafari, Bobak J Mortazavi

Cardiovascular disorders cause nearly one in three deaths in the United States. Short- and long-term care for these disorders is often determined in short-term settings. However, these decisions are made with minimal longitudinal and long-term data. To overcome this bias towards data from acute care settings, improved longitudinal monitoring for cardiovascular patients is needed. Longitudinal monitoring provides a more comprehensive picture of patient health, allowing for informed decision making. This work surveys sensing and machine learning in the field of remote health monitoring for cardiovascular disorders. We highlight three needs in the design of new smart health technologies: (1) need for sensing technologies that track longitudinal trends of the cardiovascular disorder despite infrequent, noisy, or missing data measurements; (2) need for new analytic techniques designed in a longitudinal, continual fashion to aid in the development of new risk prediction techniques and in tracking disease progression; and (3) need for personalized and interpretable machine learning techniques, allowing for advancements in clinical decision making. We highlight these needs based upon the current state of the art in smart health technologies and analytics. We then discuss opportunities in addressing these needs for development of smart health technologies for the field of cardiovascular disorders and care.

在美国,近三分之一的死亡是由心血管疾病造成的。这些疾病的短期和长期治疗通常是在短期环境下决定的。然而,在做出这些决定时,纵向和长期数据极少。为了克服这种偏重急症护理数据的情况,需要改进对心血管病人的纵向监测。纵向监测可以更全面地了解患者的健康状况,从而做出明智的决策。这项研究调查了心血管疾病远程健康监测领域的传感和机器学习。我们强调了新型智能健康技术设计中的三个需求:(1) 需要能跟踪心血管疾病纵向趋势的传感技术,尽管数据测量不频繁、有噪声或缺失;(2) 需要以纵向、持续的方式设计新的分析技术,以帮助开发新的风险预测技术和跟踪疾病进展;(3) 需要个性化和可解释的机器学习技术,以促进临床决策。我们根据智能健康技术和分析的当前技术水平强调了这些需求。然后,我们将讨论满足这些需求的机会,以便为心血管疾病和护理领域开发智能健康技术。
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引用次数: 0
Ensemble Deep Learning on Wearables Using Small Datasets 基于小数据集的可穿戴设备集成深度学习
Pub Date : 2020-12-30 DOI: 10.1145/3428666
Taylor R. Mauldin, A. Ngu, V. Metsis, Marc E. Canby
This article presents an in-depth experimental study of Ensemble Deep Learning techniques on small datasets for the analysis of time-series data generated by wearable devices. Deep Learning networks generally require large datasets for training. In some health care applications, such as the real-time smartwatch-based fall detection, there are no publicly available, large, annotated datasets that can be used for training, due to the nature of the problem (i.e., a fall is not a common event). We conducted a series of offline experiments using two different datasets of simulated falls for training various ensemble models. Our offline experimental results show that an ensemble of Recurrent Neural Network (RNN) models, combined by the stacking ensemble technique, outperforms a single RNN model trained on the same data samples. Nonetheless, fall detection models trained on simulated falls and activities of daily living performed by test subjects in a controlled environment, suffer from low precision due to high false-positive rates. In this work, through a set of real-world experiments, we demonstrate that the low precision can be mitigated via the collection of false-positive feedback by the end-users. The final Ensemble RNN model, after re-training with real-world user archived data and feedback, achieved a significantly higher precision without reducing much of the recall in a real-world setting.
本文在小数据集上对集成深度学习技术进行了深入的实验研究,用于分析可穿戴设备生成的时间序列数据。深度学习网络通常需要大型数据集进行训练。在一些医疗保健应用中,例如基于实时智能手表的跌倒检测,由于问题的性质(即跌倒不是常见事件),没有公开可用的大型注释数据集可用于训练。我们使用两种不同的模拟跌倒数据集进行了一系列的离线实验,以训练各种集成模型。我们的离线实验结果表明,通过叠加集成技术结合的循环神经网络(RNN)模型集成优于在相同数据样本上训练的单个RNN模型。尽管如此,测试对象在受控环境中进行的模拟跌倒和日常生活活动训练的跌倒检测模型由于假阳性率高,精度较低。在这项工作中,通过一组现实世界的实验,我们证明了低精度可以通过收集最终用户的假正反馈来缓解。最终的集成RNN模型,在使用真实世界用户存档数据和反馈进行重新训练后,在不降低真实世界召回率的情况下,实现了更高的精度。
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引用次数: 5
Perception Clusters 感知集群
Pub Date : 2020-12-30 DOI: 10.1145/3422819
Aftab Khan, Alexandros Zenonos, G. Kalogridis, Yaowei Wang, Stefanos Vatsikas, M. Sooriyabandara
Automated mood recognition has been studied in recent times with great emphasis on stress in particular. Other affective states are also of great importance, as studying them can help in understanding human behaviours in more detail. Most of the studies conducted in the realisation of an automated system that is capable of recognising human moods have established that mood is personal—that is, mood perception differs amongst individuals. Previous machine learning--based frameworks confirm this hypothesis, with personalised models almost always outperforming the generalised methods. In this article, we propose a novel system for grouping individuals in what we refer to as “perception clusters” based on their physiological signals. We evaluate perception clusters with a trial of nine users in a work environment, recording physiological and activity data for at least 10 days. Our results reveal no significant difference in performance with respect to a personalised approach and that our method performs equally better against traditional generalised methods. Such an approach significantly reduces computational requirements that are otherwise necessary for personalised approaches requiring individual models developed separately for each user. Further, perception clusters manifest a direction towards semi-supervised affective modelling in which individual perceptions are inferred from the data.
近年来,人们对自动情绪识别进行了研究,特别是对压力的研究。其他情感状态也非常重要,因为研究它们可以帮助更详细地理解人类行为。大多数为实现能够识别人类情绪的自动化系统而进行的研究都表明,情绪是个人的——也就是说,情绪感知在个体之间有所不同。先前基于机器学习的框架证实了这一假设,个性化模型几乎总是优于通用方法。在这篇文章中,我们提出了一种新的系统,根据个体的生理信号将其分组为我们所称的“感知簇”。我们在工作环境中对九名用户进行了试验,记录了至少10天的生理和活动数据,以评估感知集群。我们的结果表明,与个性化方法相比,性能没有显著差异,而且我们的方法与传统的通用方法相比表现同样更好。这种方法显著降低了个性化方法所需的计算需求,而个性化方法需要为每个用户单独开发单独的模型。此外,感知集群表明了向半监督情感建模的方向,在半监督情感模型中,个体感知是从数据中推断出来的。
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引用次数: 0
期刊
ACM transactions on computing for healthcare
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