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An Interpretable Trend Analysis Neural Networks for Longitudinal Data Analysis 用于纵向数据分析的可解释趋势分析神经网络
Pub Date : 2024-02-19 DOI: 10.1145/3648105
Zhenjie Yao, Yixin Chen, Jinwei Wang, Junjuan Li, Shuohua Chen, Shouling Wu, Yanhui Tu, Ming-Hui Zhao, Luxia Zhang
Cohort study is one of the most commonly used study methods in medical and public health researches, which result in longitudinal data. Conventional statistical models and machine learning methods are not capable of modeling the evolution trend of the variables in longitudinal data. In this paper, we propose a Trend Analysis Neural Networks (TANN), which models the evolution trend of the variables by adaptive feature learning. TANN was tested on dataset of Kaiuan research. The task was to predict occurrence of cardiovascular events within 2 and 5 years, with 3 repeated medical examinations during 2008 and 2013. For 2-year prediction, The AUC of the TANN is 0.7378, which is a significant improvement than that of conventional methods, while that of TRNS, RNN, DNN, GBDT, RF, and LR are 0.7222, 0.7034, 0.7054, 0.7136, 0.7160 and 0.7024, respectively. For 5-year prediction, TANN also shows improvement. The experimental results show that the proposed TANN achieves better prediction performance on cardiovascular events prediction than conventional models. Furthermore, by analyzing the weights of TANN, we could find out important trends of the indicators, which are ignored by conventional machine learning models. The trend discovery mechanism interprets the model well. TANN is an appropriate balance between high performance and interpretability.
队列研究是医学和公共卫生研究中最常用的研究方法之一,其结果是纵向数据。传统的统计模型和机器学习方法无法对纵向数据中变量的演变趋势进行建模。本文提出了一种趋势分析神经网络(TANN),它通过自适应特征学习对变量的演变趋势进行建模。我们在开元研究的数据集上对 TANN 进行了测试。任务是通过 2008 年和 2013 年期间的 3 次重复体检预测 2 年和 5 年内心血管事件的发生率。在 2 年预测中,TANN 的 AUC 为 0.7378,比传统方法显著提高,而 TRNS、RNN、DNN、GBDT、RF 和 LR 的 AUC 分别为 0.7222、0.7034、0.7054、0.7136、0.7160 和 0.7024。在 5 年期预测方面,TANN 也有所改进。实验结果表明,与传统模型相比,所提出的 TANN 在心血管事件预测方面取得了更好的预测效果。此外,通过分析 TANN 的权重,我们可以发现指标的重要趋势,而传统的机器学习模型会忽略这些趋势。趋势发现机制很好地解释了模型。TANN 在高性能和可解释性之间取得了适当的平衡。
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引用次数: 0
WalkingWizard - A truly wearable EEG headset for everyday use WalkingWizard - 适合日常使用的真正可佩戴脑电图耳机
Pub Date : 2024-02-15 DOI: 10.1145/3648106
Teck Lun Goh, L. Peh
Electroencephalography (EEG) provides an opportunity to gain insights to electrocortical activity without the need for invasive technology. While increasingly used in various application areas, EEG headsets tend to be suited only to a laboratory environment due to the long preparation time to don the headset and the need for users to remain stationary. We present our design of a dry, dual-electrodes flexible PCB assembly that realizes accurate sensing in face of practical motion artifacts. Using it, we present WalkingWizard, our prototype dry-electrode EEG baseball cap that can be used under motion in everyday scenarios. We first evaluated its hardware performance by comparing its electrode-scalp impedance and ability to capture alpha rhythm against both wet EEG, and commercially available dry EEG headsets. We then tested WalkingWizard using SSVEP experiments, achieving high classification accuracy of 87% for walking speeds up to 5.0km/hr, beating state-of-the-art. Expanding on WalkingWizard, we integrated all necessary electronic components into a flexible PCB assembly - realizing WalkingWizard Integrated , in a truly wearable form-factor. Utilizing WalkingWizard Integrated, we demonstrated several applications as proof-of-concept: Classification of SSVEP in VR environment while walking, Real-time acquisition of emotional state of users while moving around the neighbourhood, and Understanding the effect of guided meditation for relaxation.
脑电图(EEG)提供了一个无需侵入性技术即可深入了解皮层电活动的机会。虽然脑电图耳机越来越多地应用于各个领域,但由于佩戴耳机的准备时间较长,而且用户需要保持静止不动,因此往往只适用于实验室环境。我们介绍了我们设计的干式双电极柔性 PCB 组件,它能在实际运动伪影面前实现精确传感。利用它,我们推出了 WalkingWizard,这是我们的干电极脑电图棒球帽原型,可在日常运动场景下使用。我们首先评估了它的硬件性能,将其电极鳞片阻抗和捕捉α节律的能力与湿式脑电图和市售干式脑电图耳机进行了比较。然后,我们使用 SSVEP 实验对 WalkingWizard 进行了测试,在步行速度高达 5.0km/hr 的情况下,分类准确率高达 87%,超过了最先进的水平。在 WalkingWizard 的基础上,我们将所有必要的电子元件集成到一个灵活的印刷电路板组件中--实现了 WalkingWizard Integrated,具有真正的可穿戴外形。利用 WalkingWizard Integrated,我们展示了几个应用作为概念验证:步行时在 VR 环境中对 SSVEP 进行分类、在社区中移动时实时获取用户的情绪状态,以及了解引导式冥想对放松的影响。
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引用次数: 0
WalkingWizard - A truly wearable EEG headset for everyday use WalkingWizard - 适合日常使用的真正可佩戴脑电图耳机
Pub Date : 2024-02-15 DOI: 10.1145/3648106
Teck Lun Goh, L. Peh
Electroencephalography (EEG) provides an opportunity to gain insights to electrocortical activity without the need for invasive technology. While increasingly used in various application areas, EEG headsets tend to be suited only to a laboratory environment due to the long preparation time to don the headset and the need for users to remain stationary. We present our design of a dry, dual-electrodes flexible PCB assembly that realizes accurate sensing in face of practical motion artifacts. Using it, we present WalkingWizard, our prototype dry-electrode EEG baseball cap that can be used under motion in everyday scenarios. We first evaluated its hardware performance by comparing its electrode-scalp impedance and ability to capture alpha rhythm against both wet EEG, and commercially available dry EEG headsets. We then tested WalkingWizard using SSVEP experiments, achieving high classification accuracy of 87% for walking speeds up to 5.0km/hr, beating state-of-the-art. Expanding on WalkingWizard, we integrated all necessary electronic components into a flexible PCB assembly - realizing WalkingWizard Integrated , in a truly wearable form-factor. Utilizing WalkingWizard Integrated, we demonstrated several applications as proof-of-concept: Classification of SSVEP in VR environment while walking, Real-time acquisition of emotional state of users while moving around the neighbourhood, and Understanding the effect of guided meditation for relaxation.
脑电图(EEG)提供了一个无需侵入性技术即可深入了解皮层电活动的机会。虽然脑电图耳机越来越多地应用于各个领域,但由于佩戴耳机的准备时间较长,而且用户需要保持静止不动,因此往往只适用于实验室环境。我们介绍了我们设计的干式双电极柔性 PCB 组件,它能在实际运动伪影面前实现精确传感。利用它,我们推出了 WalkingWizard,这是我们的干电极脑电图棒球帽原型,可在日常运动场景下使用。我们首先评估了它的硬件性能,将其电极鳞片阻抗和捕捉α节律的能力与湿式脑电图和市售干式脑电图耳机进行了比较。然后,我们使用 SSVEP 实验对 WalkingWizard 进行了测试,在步行速度高达 5.0km/hr 的情况下,分类准确率高达 87%,超过了最先进的水平。在 WalkingWizard 的基础上,我们将所有必要的电子元件集成到一个灵活的印刷电路板组件中--实现了 WalkingWizard Integrated,具有真正的可穿戴外形。利用 WalkingWizard Integrated,我们展示了几个应用作为概念验证:步行时在 VR 环境中对 SSVEP 进行分类、在社区中移动时实时获取用户的情绪状态,以及了解引导式冥想对放松的影响。
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引用次数: 0
Enhancing Robust Liver Cancer Diagnosis: A Contrastive Multi-Modality Learner with Lightweight Fusion and Effective Data Augmentation 增强肝癌诊断的鲁棒性:具有轻量级融合和有效数据增强功能的多模态对比学习器
Pub Date : 2023-12-30 DOI: 10.1145/3639414
Pei-Xuan Li, Hsun-Ping Hsieh, Chiang Fan Yang, Ding-You Wu, Ching-Chung Ko
This paper explores the application of self-supervised contrastive learning in the medical domain, focusing on classification of multi-modality Magnetic Resonance (MR) images. To address the challenges of limited and hard-to-annotate medical data, we introduce multi-modality data augmentation (MDA) and cross-modality group convolution (CGC). In the pre-training phase, we leverage Simple Siamese networks to maximize the similarity between two augmented MR images from a patient, without a handcrafted pretext task. Our approach also combines 3D and 2D group convolution with a channel shuffle operation to efficiently incorporate different modalities of image features. Evaluation on liver MR images from a well-known hospital in Taiwan demonstrates a significant improvement over previous methods. This work contributes to advancing multi-modality contrastive learning, particularly in the context of medical imaging, offering enhanced tools for analyzing complex image data.
本文探讨了自监督对比学习在医疗领域的应用,重点是多模态磁共振(MR)图像的分类。为了应对医疗数据有限且难以标注的挑战,我们引入了多模态数据增强(MDA)和跨模态群卷积(CGC)。在预训练阶段,我们利用简单连体网络(Simple Siamese networks)来最大化患者两幅增强磁共振图像之间的相似性,而无需手工制作借口任务。我们的方法还将三维和二维群卷积与通道洗牌操作相结合,有效地整合了不同模式的图像特征。在台湾一家知名医院的肝脏磁共振图像上进行的评估表明,我们的方法比以前的方法有了显著的改进。这项工作有助于推进多模态对比学习,尤其是在医学成像方面,为分析复杂图像数据提供了更强大的工具。
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引用次数: 0
Subsampled Randomized Hadamard Transformation based Ensemble Extreme Learning Machine for Human Activity Recognition 基于子采样随机哈达玛变换的集合极限学习机用于人类活动识别
Pub Date : 2023-11-27 DOI: 10.1145/3634813
Dipanwita Thakur, Arindam Pal
Extreme Learning Machine (ELM) is becoming a popular learning algorithm due to its diverse applications, including Human Activity Recognition (HAR). In ELM, the hidden node parameters are generated at random, and the output weights are computed analytically. However, even with a large number of hidden nodes, feature learning using ELM may not be efficient for natural signals due to its shallow architecture. Due to noisy signals of the smartphone sensors and high dimensional data, substantial feature engineering is required to obtain discriminant features and address the “curse-of-dimensionality”. In traditional ML approaches, dimensionality reduction and classification are two separate and independent tasks, increasing the system’s computational complexity. This research proposes a new ELM-based ensemble learning framework for human activity recognition to overcome this problem. The proposed architecture consists of two key parts: 1) Self-taught dimensionality reduction followed by classification. 2) they are bridged by “Subsampled Randomized Hadamard Transformation” (SRHT). Two different HAR datasets are used to establish the feasibility of the proposed framework. The experimental results clearly demonstrate the superiority of our method over the current state-of-the-art methods.
极限学习机(ELM)因其广泛的应用而成为一种流行的学习算法,包括人类活动识别(HAR)。在 ELM 中,隐藏节点的参数是随机生成的,输出权重是通过分析计算得出的。然而,即使有大量的隐藏节点,由于其架构较浅,使用 ELM 进行特征学习对于自然信号可能并不有效。由于智能手机传感器信号嘈杂,数据维度高,因此需要大量的特征工程来获取判别特征,解决 "维度诅咒 "问题。在传统的 ML 方法中,降维和分类是两个独立的任务,增加了系统的计算复杂度。为克服这一问题,本研究提出了一种新的基于 ELM 的人类活动识别集合学习框架。建议的架构由两个关键部分组成:1)自学降维,然后是分类。2)通过 "子采样随机哈达玛变换"(SRHT)将它们连接起来。我们使用了两个不同的 HAR 数据集来确定所提框架的可行性。实验结果清楚地证明了我们的方法优于目前最先进的方法。
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引用次数: 0
Application of Smart Insoles for Recognition of Activities of Daily Living: A Systematic Review 应用智能鞋垫识别日常生活活动:系统回顾
Pub Date : 2023-11-24 DOI: 10.1145/3633785
Luigi D’Arco, Graham McCalmont, Haiying Wang, Huiru Zheng
Recent years have witnessed the increasing literature on using smart insoles in health and well-being, and yet, their capability of daily living activity recognition has not been reviewed. This paper addressed this need and provided a systematic review of smart insole-based systems in the recognition of Activities of Daily Living (ADLs). The review followed the PRISMA guidelines, assessing the sensing elements used, the participants involved, the activities recognised, and the algorithms employed. The findings demonstrate the feasibility of using smart insoles for recognising ADLs, showing their high performance in recognising ambulation and physical activities involving the lower body, ranging from 70% to 99.8% of Accuracy, with 13 studies over 95%. The preferred solutions have been those including machine learning. A lack of existing publicly available datasets has been identified, and the majority of the studies were conducted in controlled environments. Furthermore, no studies assessed the impact of different sampling frequencies during data collection, and a trade-off between comfort and performance has been identified between the solutions. In conclusion, real-life applications were investigated showing the benefits of smart insoles over other solutions and placing more emphasis on the capabilities of smart insoles.
近年来,有关智能鞋垫在健康和福祉领域应用的文献越来越多,然而,有关其日常生活活动识别能力的研究却鲜有问世。本文针对这一需求,对基于智能鞋垫的日常生活活动(ADL)识别系统进行了系统综述。综述遵循了 PRISMA 准则,评估了所使用的传感元件、参与人员、所识别的活动以及所采用的算法。研究结果表明了使用智能鞋垫识别日常生活活动的可行性,显示了智能鞋垫在识别涉及下半身的行走和体力活动方面的高性能,准确率从 70% 到 99.8%,其中有 13 项研究的准确率超过 95%。包括机器学习在内的解决方案一直是首选。目前已发现缺乏公开可用的数据集,而且大多数研究都是在受控环境中进行的。此外,没有研究对数据采集过程中不同采样频率的影响进行评估,而且在各种解决方案之间还存在舒适度和性能之间的权衡问题。总之,对实际应用的调查显示了智能鞋垫相对于其他解决方案的优势,并更加强调了智能鞋垫的功能。
{"title":"Application of Smart Insoles for Recognition of Activities of Daily Living: A Systematic Review","authors":"Luigi D’Arco, Graham McCalmont, Haiying Wang, Huiru Zheng","doi":"10.1145/3633785","DOIUrl":"https://doi.org/10.1145/3633785","url":null,"abstract":"Recent years have witnessed the increasing literature on using smart insoles in health and well-being, and yet, their capability of daily living activity recognition has not been reviewed. This paper addressed this need and provided a systematic review of smart insole-based systems in the recognition of Activities of Daily Living (ADLs). The review followed the PRISMA guidelines, assessing the sensing elements used, the participants involved, the activities recognised, and the algorithms employed. The findings demonstrate the feasibility of using smart insoles for recognising ADLs, showing their high performance in recognising ambulation and physical activities involving the lower body, ranging from 70% to 99.8% of Accuracy, with 13 studies over 95%. The preferred solutions have been those including machine learning. A lack of existing publicly available datasets has been identified, and the majority of the studies were conducted in controlled environments. Furthermore, no studies assessed the impact of different sampling frequencies during data collection, and a trade-off between comfort and performance has been identified between the solutions. In conclusion, real-life applications were investigated showing the benefits of smart insoles over other solutions and placing more emphasis on the capabilities of smart insoles.","PeriodicalId":72043,"journal":{"name":"ACM transactions on computing for healthcare","volume":"49 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139239470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining Deep Learning with Signal-image Encoding for Multi-Modal Mental Wellbeing Classification 结合深度学习和信号-图像编码的多模态心理健康分类
Pub Date : 2023-11-03 DOI: 10.1145/3631618
Kieran Woodward, Eiman Kanjo, Athanasios Tsanas
The quantification of emotional states is an important step to understanding wellbeing. Time series data from multiple modalities such as physiological and motion sensor data have proven to be integral for measuring and quantifying emotions. Monitoring emotional trajectories over long periods of time inherits some critical limitations in relation to the size of the training data. This shortcoming may hinder the development of reliable and accurate machine learning models. To address this problem, this paper proposes a framework to tackle the limitation in performing emotional state recognition: 1) encoding time series data into coloured images; 2) leveraging pre-trained object recognition models to apply a Transfer Learning (TL) approach using the images from step 1; 3) utilising a 1D Convolutional Neural Network (CNN) to perform emotion classification from physiological data; 4) concatenating the pre-trained TL model with the 1D CNN. We demonstrate that model performance when inferring real-world wellbeing rated on a 5-point Likert scale can be enhanced using our framework, resulting in up to 98.5% accuracy, outperforming a conventional CNN by 4.5%. Subject-independent models using the same approach resulted in an average of 72.3% accuracy (SD 0.038). The proposed methodology helps improve performance and overcome problems with small training datasets.
情绪状态的量化是理解幸福的重要一步。来自多种模式的时间序列数据,如生理和运动传感器数据,已被证明是测量和量化情绪的组成部分。长时间监测情绪轨迹继承了一些与训练数据大小有关的关键限制。这个缺点可能会阻碍可靠和准确的机器学习模型的发展。为了解决这一问题,本文提出了一个框架来解决执行情绪状态识别的局限性:1)将时间序列数据编码为彩色图像;2)利用预训练的对象识别模型,使用第1步的图像应用迁移学习(TL)方法;3)利用一维卷积神经网络(CNN)对生理数据进行情绪分类;4)将预训练的TL模型与1D CNN拼接。我们证明,使用我们的框架可以提高模型在推断5点李克特量表上的真实世界幸福感时的表现,准确率高达98.5%,比传统的CNN高出4.5%。使用相同方法的受试者独立模型的平均准确率为72.3% (SD 0.038)。所提出的方法有助于提高性能并克服小型训练数据集的问题。
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引用次数: 0
A Comprehensive Picture of Factors Affecting User Willingness to Use Mobile Health Applications 影响用户使用移动健康应用程序意愿的因素的综合图片
Pub Date : 2023-10-10 DOI: 10.1145/3626962
Shaojing Fan, Ramesh C. Jain, Mohan S. Kankanhalli
Mobile health (mHealth) applications have become increasingly valuable in preventive healthcare and in reducing the burden on healthcare organizations. The aim of this paper is to investigate the factors that influence user acceptance of mHealth apps and identify the underlying structure that shapes users’ behavioral intention. An online study that employed factorial survey design with vignettes was conducted, and a total of 1,669 participants from eight countries across four continents were included in the study. Structural equation modeling was employed to quantitatively assess how various factors collectively contribute to users’ willingness to use mHealth apps. The results indicate that users’ digital literacy has the strongest impact on their willingness to use them, followed by their online habit of sharing personal information. Users’ concerns about personal privacy only had a weak impact. Furthermore, users’ demographic background, such as their country of residence, age, ethnicity, and education, has a significant moderating effect. Our findings have implications for app designers, healthcare practitioners, and policymakers. Efforts are needed to regulate data collection and sharing and promote digital literacy among the general population to facilitate the widespread adoption of mHealth apps.
移动医疗(mHealth)应用程序在预防性医疗保健和减轻医疗保健组织负担方面变得越来越有价值。本文的目的是调查影响用户接受移动健康应用程序的因素,并确定塑造用户行为意图的底层结构。采用因子调查设计和小插图进行了一项在线研究,来自四大洲八个国家的1,669名参与者被纳入研究。结构方程模型用于定量评估各种因素如何共同影响用户使用移动健康应用程序的意愿。结果表明,用户的数字素养对其使用意愿的影响最大,其次是他们分享个人信息的在线习惯。用户对个人隐私的担忧只产生了微弱的影响。此外,用户的人口统计背景,如他们的居住国、年龄、种族和教育程度,具有显著的调节作用。我们的研究结果对应用程序设计师、医疗从业者和政策制定者具有启示意义。需要努力规范数据收集和共享,并促进普通民众的数字素养,以促进移动健康应用程序的广泛采用。
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引用次数: 0
Inter-Beat Interval Estimation with Tiramisu Model: A Novel Approach with Reduced Error 用提拉米苏模型估计拍间间隔:一种误差小的新方法
Pub Date : 2023-10-06 DOI: 10.1145/3616020
Asiful Arefeen, Ali Akbari, Seyed Iman Mirzadeh, Roozbeh Jafari, Behrooz A. Shirazi, Hassan Ghasemzadeh
Inter-beat interval (IBI) measurement enables estimation of heart-tare variability (HRV) which, in turns, can provide early indication of potential cardiovascular diseases (CVDs). However, extracting IBIs from noisy signals is challenging since the morphology of the signal gets distorted in the presence of noise. Electrocardiogram (ECG) of a person in heavy motion is highly corrupted with noise, known as motion-artifact, and IBI extracted from it is inaccurate. As a part of remote health monitoring and wearable system development, denoising ECG signals and estimating IBIs correctly from them have become an emerging topic among signal-processing researchers. Apart from conventional methods, deep-learning techniques have been successfully used in signal denoising recently, and diagnosis process has become easier, leading to accuracy levels that were previously unachievable. We propose a deep-learning approach leveraging tiramisu autoencoder model to suppress motion-artifact noise and make the R-peaks of the ECG signal prominent even in the presence of high-intensity motion. After denoising, IBIs are estimated more accurately expediting diagnosis tasks. Results illustrate that our method enables IBI estimation from noisy ECG signals with SNR up to -30dB with average root mean square error (RMSE) of 13 milliseconds for estimated IBIs. At this noise level, our error percentage remains below 8% and outperforms other state of the art techniques.
心跳间隔(IBI)测量可以估计心脏变异性(HRV),进而可以提供潜在心血管疾病(cvd)的早期指示。然而,从噪声信号中提取ibi是具有挑战性的,因为信号的形态在噪声的存在下会被扭曲。人体剧烈运动时的心电图受到噪声的严重干扰,被称为运动伪影,从中提取的IBI是不准确的。作为远程健康监测和可穿戴系统开发的一部分,心电信号去噪和正确估计ibi已成为信号处理研究的新兴课题。除传统方法外,深度学习技术最近已成功用于信号去噪,并且诊断过程变得更加容易,从而达到以前无法实现的精度水平。我们提出了一种利用提拉米苏自编码器模型的深度学习方法来抑制运动伪影噪声,并使心电信号的r峰即使在高强度运动存在时也能突出。去噪后,ibi的估计更准确,加快了诊断任务。结果表明,我们的方法能够从噪声心电信号中估计IBI,信噪比高达-30dB,估计IBI的平均均方根误差(RMSE)为13毫秒。在这种噪声水平下,我们的错误率保持在8%以下,优于其他最先进的技术。
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引用次数: 0
Clinical Phenotyping with an Outcomes-driven Mixture of Experts for Patient Matching and Risk Estimation. 基于结果驱动的患者匹配和风险评估专家混合的临床表型
Pub Date : 2023-10-01 Epub Date: 2023-09-13 DOI: 10.1145/3616021
Nathan C Hurley, Sanket S Dhruva, Nihar R Desai, Joseph R Ross, Che G Ngufor, Frederick Masoudi, Harlan M Krumholz, Bobak J Mortazavi

Observational medical data present unique opportunities for analysis of medical outcomes and treatment decision making. However, because these datasets do not contain the strict pairing of randomized control trials, matching techniques are to draw comparisons among patients. A key limitation to such techniques is verification that the variables used to model treatment decision making are also relevant in identifying the risk of major adverse events. This article explores a deep mixture of experts approach to jointly learn how to match patients and model the risk of major adverse events in patients. Although trained with information regarding treatment and outcomes, after training, the proposed model is decomposable into a network that clusters patients into phenotypes from information available before treatment. This model is validated on a dataset of patients with acute myocardial infarction complicated by cardiogenic shock. The mixture of experts approach can predict the outcome of mortality with an area under the receiver operating characteristic curve of 0.85 ± 0.01 while jointly discovering five potential phenotypes of interest. The technique and interpretation allow for identifying clinically relevant phenotypes that may be used both for outcomes modeling as well as potentially evaluating individualized treatment effects.

观察性医学数据为分析医疗结果和治疗决策提供了独特的机会。然而,由于这些数据集不包含随机对照试验的严格配对,配对技术是为了在患者之间进行比较。这种技术的一个关键限制是验证用于模拟治疗决策的变量也与确定主要不良事件的风险相关。本文探讨了一种深度混合的专家方法,共同学习如何匹配患者并模拟患者主要不良事件的风险。虽然训练了有关治疗和结果的信息,但在训练之后,所提出的模型可分解成一个网络,该网络根据治疗前可用的信息将患者聚类为表型。该模型在急性心肌梗死合并心源性休克患者的数据集上得到了验证。专家混合法在共同发现5种潜在感兴趣表型的同时,预测死亡率的结果在受试者工作特征曲线下的面积为0.85±0.01。该技术和解释允许识别临床相关表型,这些表型可用于结果建模以及潜在的评估个体化治疗效果。
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引用次数: 0
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ACM transactions on computing for healthcare
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